Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3563 papers with ECcit ≥ 1011.3
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 22, June 2022

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1222364222364.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2169609169609.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328432971082.20.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
410284051420.02624.421312.2Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54365843658.01435.941435.9A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63446934469.01116.61116.6Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76512032560.01970.32985.2Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83019730197.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92604326043.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102579725797.0589.67589.7MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112413724137.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
122296922969.0720.38720.4Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
132282322823.0560.25560.2MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
142221322213.0523.62523.6A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
156550321834.30.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
166186720622.30.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
172003120031.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
181900519005.0670.75670.8Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
193757018785.01165.54582.8The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
201850018500.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
215323617745.30.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
223521717608.51210.73605.4Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
233380416902.01629.02814.5Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
241680516805.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
251633416334.0421.77421.8Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
261620516205.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
271590815908.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
281583115831.0590.89590.9A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
293099915499.50.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
303024715123.50.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
314388014626.71264.44421.5CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
321425514255.0418.75418.8Projector augmented-wave method. BlöchlPhys Rev B Condens Matter19949976227Yes
331406914069.0378.1378.1MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
344076813589.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
351351113511.0568.21568.2A power primer. J CohenPsychol Bull199219565683Yes
362670813354.01026.81513.4Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
372637413187.01089.29544.6The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
381302713027.0646.25646.2RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
391262512625.0499.46499.5Catalase in vitro. H AebiMethods Enzymol19846727660Yes
401261912619.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
413680812269.31134.92378.3Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys Rev Lett199610062328Yes
425733411466.81657.88331.6Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
432287411437.0622.9311.4Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
442249211246.0946.12473.1The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
453361111203.71221.19407.1Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys Rev B Condens Matter19889944570Yes
462226711133.5483.53241.8Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
472172110860.5770.8385.4Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
482156310781.5560.14280.1A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
491072610726.0360.67360.7Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
501064410644.0377.39377.4Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
511045710457.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
522069010345.0462.35231.2[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
531033410334.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
541032110321.0317.09317.1The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
551027510275.0287.88287.9Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
561019610196.0383.62383.6Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
571000310003.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
5899879987.0625.3625.3Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
59197859892.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
6096199619.0376.32376.3A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
61188909445.0529.51264.8Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
6294389438.0321.31321.3Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
63185909295.0536.04268.0Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys Rev B Condens Matter19969984901Yes
6492559255.0269.55269.6Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
65184919245.5830.42415.2The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
66183409170.0482.1241.1A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
6791569156.0243.46243.5Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
6890929092.0260.6260.6The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
6989798979.0235.92235.9Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
7088258825.0191.92191.9Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
7187858785.0251.31251.3Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7287438743.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7386718671.0235.57235.6RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
74258988632.7689.13229.7VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
7585698569.0263.34263.3Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
76338728468.01009.43252.4Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
77253708456.71076.0358.7Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
78168038401.5364.54182.3The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
79334308357.51398.85349.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
8083198319.0175.6175.6Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
8182168216.0366.12366.1Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8280588058.0230.36230.4Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8380128012.0175.8175.8The functions of animal microRNAs. Victor AmbrosNature200415372042No
8480088008.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
85312177804.21192.76298.2A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
8677987798.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
8777887788.0297.35297.4Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
8877867786.0218.55218.6The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
8977777777.0209.16209.2Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
9077697769.0218.56218.6"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
91231757725.0870.24290.1NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
9277177717.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
93154297714.5358.51179.3Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
94231117703.7636.85212.3Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9575787578.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
9674487448.0244.26244.3The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
97293997349.8974.84243.7Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
98145987299.0408.64204.3Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
9972737273.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
100145467273.0637.54318.8MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
10172587258.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
102145087254.0364.16182.1MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
103217367245.3990.84330.3Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
10472337233.0197.43197.4Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
10571927192.0329.57329.6Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
10671827182.0216.76216.8AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
10771707170.0182.59182.6PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
108141387069.0312.52156.3KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
10970417041.0239.58239.6Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys Rev B Condens Matter19869938299Yes
110491477021.01290.91184.4Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
11170147014.0193.09193.1TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
112210417013.70.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
11369546954.0328.34328.3Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11469476947.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
11569476947.0157.32157.3Chromatin modifications and their function. Tony KouzaridesCell200717320507No
11669006900.0186.55186.6Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
117135946797.0312.77156.4Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11867956795.0184.76184.8The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
119135576778.50.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
120135196759.5289.21144.6 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
12167506750.0188.01188.0Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
12267026702.0171.49171.5Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12366866686.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
12466836683.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
125196816560.3560.28186.8A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
126195646521.31373.2457.7MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
12765196519.0172.66172.7Adhesion receptors of the immune system. T A SpringerNature19901974032No
12864776477.0199.29199.3The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
12964316431.0169.46169.5Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
130128056402.50.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
131382836380.53699.82616.6Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
13263666366.0130.35130.3Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
133127086354.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
13462956295.0208.88208.9Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
13562466246.0204.82204.8The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
13662146214.0135.67135.7p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
137122076103.50.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
13860726072.0124.89124.9Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
139120976048.50.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
14060466046.0150.24150.2Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
14160436043.0294.67294.7UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
14260236023.0320.22320.2Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
143240026000.50.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
14459815981.0152.85152.8Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
14559535953.0134.78134.8Inflammation in atherosclerosis. Peter LibbyNature200212490960No
14659455945.0152.41152.4G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
147118665933.00.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14859235923.0146.52146.5Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
149176185872.7563.25187.8Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
150175825860.7508.06169.4edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
151116485824.0411.08205.5The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15257845784.0141.16141.2Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
15357695769.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15457465746.0206.9206.9The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
15557205720.0138.55138.6Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
15656735673.0144.39144.4Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
157113385669.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
158169585652.7520.47173.5The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
159168345611.30.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
160111995599.5278.52139.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
161111835591.5399.2199.6Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
16255675567.0337.31337.3SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
163111115555.5300.38150.2Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
16455535553.0108.03108.0BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
165110605530.0252.47126.2Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
16654915491.0131.48131.5Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
167109335466.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
16854595459.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
16953995399.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
170107905395.0364.21182.1AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
17153635363.0126.11126.1Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
172107105355.0252.15126.1Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17353545354.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
17453505350.0119.52119.5The biochemistry of apoptosis. M O HengartnerNature200011048727No
17553455345.0136.65136.7New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
17653285328.0135.57135.6Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
17752985298.0141.12141.1The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
178158755291.7480.33160.1A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
17952785278.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
18052695269.0153.7153.7Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
181105295264.5300.64150.3MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
182105185259.0252.8126.4A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
18352395239.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18452345234.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
185104505225.0236.55118.3One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18652255225.0146.56146.6A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
187104475223.5269.78134.9BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
18852215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
18952215221.0175.9175.9jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
19051845184.0126.97127.0The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
19151815181.0190.33190.3Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
19251775177.0210.06210.1Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
193258435168.6706.49141.3The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
19451655165.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
19551445144.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
196205255131.2708.49177.1G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
197102615130.5288.46144.2Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
198101685084.0373.25186.6The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
199101255062.5290.82145.4EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
200100965048.0269.31134.7Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
20150315031.0186.26186.3Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
20249934993.0102.37102.4Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
20349924992.0100.75100.8Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
20449884988.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
20549794979.0150.36150.4Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
206148434947.7540.84180.3Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
20749294929.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
20898364918.00.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
20998034901.5357.25178.6Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
21048514851.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
211145374845.7395.18131.7Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
21248404840.0143.49143.5A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
21396724836.0213.62106.8Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
214144734824.3361.34120.4A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
21548064806.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
21648034803.0120.43120.4Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
21795964798.0232.7116.3Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
21847964796.097.6897.7An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
21947814781.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
22095474773.50.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
221142454748.3545.66181.9The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
222142244741.30.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
22347404740.0109.44109.4MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
22494714735.50.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
22594554727.5231.55115.8A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
22694024701.0211.95106.0The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
22746884688.0107.14107.1ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
22893594679.5237.96119.0Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
22946734673.0158.6158.6The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
23046704670.0104.47104.5Cancer cell cycles. C J SherrScience19968939849No
23146684668.0130.25130.2Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
23246384638.098.0898.1Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23346344634.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
234138844628.0485.44161.8Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
23546264626.0180.44180.4An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
23646254625.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
237184324608.0559.44139.9MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
23846014601.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
239230014600.21134.59226.9MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
24045904590.0127.24127.2Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
241137554585.0348.27116.1Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
24290874543.5252.22126.1Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
243135684522.7303.16101.1Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
24445224522.087.9588.0DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
24590394519.5304.67152.3Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
246225974519.40.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
24745074507.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
24844894489.0102.27102.3Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
24944844484.098.098.0ras genes. M BarbacidAnnu Rev Biochem19873304147No
25044604460.0109.62109.6A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
25188974448.50.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
25288904445.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
25344354435.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25444324432.0174.43174.4Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
25588514425.5201.42100.7Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
25644184418.0101.57101.6Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
25744064406.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
25888014400.50.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
25987864393.00.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
26087834391.5253.37126.7The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
26143914391.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
26243784378.090.1990.2Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
26343764376.0129.37129.4How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
26443454345.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
26543244324.0113.21113.2Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
266258664311.0987.41164.6Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
26743094309.0101.87101.9Cancer. p53, guardian of the genome. D P LaneNature19921614522No
26886004300.00.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
26985624281.0262.13131.1RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
27042794279.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
27185524276.0232.94116.5A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
272171014275.20.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
27342714271.0113.98114.0The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
27485324266.0238.59119.3Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
27585234261.50.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
27685214260.51709.41854.7Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
27742444244.094.1694.2Apoptosis by death factor. S NagataCell19979039262No
27842334233.0113.14113.1Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
27942284228.090.8290.8Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28042224222.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
28142124212.094.8694.9Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
28284204210.0198.0499.0SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
28342084208.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
28441964196.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
28541944194.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
286251264187.71011.42168.6MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
28741814181.099.99100.0Mechanisms of angiogenesis. W RisauNature19979109485No
28883164158.0195.497.7MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
28941504150.087.6487.6The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
29041434143.081.681.6The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
29141324132.0126.04126.0Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
29282574128.5179.4789.7Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
29341284128.087.4187.4Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
29440994099.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
29540964096.088.5888.6Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
29640874087.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
29740864086.075.7975.8Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
29881684084.00.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
299121544051.3751.56250.5Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30081014050.50.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
30140434043.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
30240344034.0139.5139.5Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
30340254025.093.093.0Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
30440084008.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
30539983998.0126.65126.7Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
30639973997.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
30739913991.0131.27131.3Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
30879533976.5194.9697.5Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
30939763976.0103.83103.8Integrins: a family of cell surface receptors. R O HynesCell19873028640No
310158273956.8446.22111.6Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
31139503950.0146.72146.7EuroQol: the current state of play. R BrooksHealth Policy199610158943No
312118063935.31381.42460.5Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
31339353935.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
31439323932.0129.13129.1Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
31539283928.088.7888.8PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
31639283928.087.687.6Atherosclerosis. A J LusisNature200011001066No
31778553927.50.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
31839233923.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
31978383919.0195.2897.6WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
32078213910.5303.3151.7Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
32178033901.5229.77114.9Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
32239013901.0107.53107.5What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
32338853885.0120.68120.7Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
32438743874.096.2196.2Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
325116203873.3519.34173.1Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
32677423871.00.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
32738623862.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
328231453857.5772.44128.7Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32938553855.082.7182.7The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
33038313831.0125.06125.1Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
33176603830.0275.8137.9Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
33238233823.0102.52102.5Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33338193819.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
33475733786.5216.75108.4Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys Rev B Condens Matter199310004490Yes
335113533784.30.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
33675633781.5144.1572.1A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
33737803780.081.081.0A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
33837803780.0104.25104.2Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
33937773777.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
34037703770.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
34137583758.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
34237553755.093.3393.3Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
343112563752.0782.61260.9Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
344112543751.30.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
345112303743.3969.54323.2Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
34637343734.0107.99108.0Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
34774593729.5254.3127.2DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
348111793726.3215.8271.9Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
34937243724.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
35037183718.076.476.4Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
35137123712.090.2590.2Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
35274063703.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
35337023702.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
35436993699.0141.27141.3Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
35536943694.083.2583.2Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
35673823691.0182.9391.5Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
35736903690.078.1578.2TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
35836813681.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
359110373679.0421.51140.5A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
36036773677.088.9989.0Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
36173463673.0312.11156.1The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
36236583658.077.5977.6Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
36336573657.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
364146183654.5394.1298.5Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
36536363636.0109.2109.2Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys Rev B Condens Matter19909993096Yes
36672573628.5187.593.8tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
36736213621.0100.73100.7Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
36872413620.50.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
36936133613.072.5472.5Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
37036123612.0122.31122.3Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
37136073607.0109.6109.6Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
37236073607.085.1785.2Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
37336003600.066.5266.5Somatic generation of antibody diversity. S TonegawaNature19836300689No
37435953595.082.7782.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37535923592.099.6199.6Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
37635753575.0100.57100.6Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
37771423571.0270.62135.3The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
37835613561.081.1681.2Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
37970593529.5133.7766.9Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
38035273527.084.5984.6Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
38170533526.5158.6179.3Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
38270453522.5185.1492.6Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38335213521.0119.95120.0How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
384140693517.2571.23142.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
38534983498.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
38634973497.0185.35185.3Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
38734943494.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
38834913491.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
38969823491.0206.97103.5BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
390104713490.3430.32143.4A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
39169713485.50.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
392174053481.0503.43100.7Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
39334773477.0103.68103.7What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
39434763476.078.3978.4Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
39534753475.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
39634603460.0115.91115.9genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
39734563456.071.2371.2Mammalian neural stem cells. F H GageScience200010688783No
39834413441.0102.73102.7Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
39968813440.5164.5782.3"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
40034403440.092.5692.6Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
40134353435.089.689.6Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
40234313431.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
403102633421.0337.5112.5Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
40434153415.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
40534143414.0133.38133.4A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
40633983398.089.6189.6Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
40733963396.0103.63103.6Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
40833933393.084.5984.6The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
409101533384.3438.53146.2Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
410101433381.00.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
41133793379.065.8765.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
41233783378.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
41333733373.079.4679.5The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
41467263363.0174.387.2TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
41533633363.090.2290.2The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
416100873362.3382.09127.4Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
41733533353.089.6189.6The origins and the future of microfluidics. George M WhitesidesNature200616871203No
418133993349.8337.8184.5Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
419200733345.51110.59185.1Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
42066813340.5124.9662.5Translating the histone code. T Jenuwein, C D AllisScience200111498575No
42133383338.093.0693.1Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
42233363336.086.5386.5I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
42333273327.069.1169.1Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
42433253325.069.1469.1The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
425232723324.6536.4576.6UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
42633213321.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
42733173317.0101.82101.8Graphene: status and prospects. A K GeimScience200919541989Yes
42899473315.7398.09132.7Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
42966313315.5171.685.8An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43033143314.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
43166263313.00.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
43233113311.084.9284.9Gene regulation by steroid hormones. M BeatoCell19892644044No
43333113311.0132.21132.2Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
43433093309.076.9577.0Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
43533043304.078.3178.3Glutamate uptake. N C DanboltProg Neurobiol200111369436No
43633043304.078.2478.2Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
437197923298.7760.91126.8Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
43898823294.0528.93176.3Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
43932903290.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
44032863286.084.5984.6Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
44132833283.070.470.4Profile hidden Markov models. S R EddyBioinformatics19989918945No
44265333266.50.00.0Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
443130643266.0304.9976.2Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
44497833261.01858.75619.6Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
44565143257.0177.3688.7The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
44632563256.0107.59107.6Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
44797113237.0422.02140.7HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
44832333233.0102.51102.5Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
44932293229.0103.99104.0Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
45032283228.094.4894.5Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
45132273227.093.293.2Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
45232243224.075.4275.4Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
45332193219.072.1572.2Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
45464303215.0240.0120.0Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
45532053205.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
456127533188.2505.22126.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
45731883188.086.3286.3ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
45863703185.0186.7193.4Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
45963693184.5183.9392.0Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
46031833183.079.4879.5The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
46163593179.5151.2675.6Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
46231683168.091.1591.2EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
46363343167.0550.15275.1A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
46463073153.5130.7665.4Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
46563043152.0124.1862.1The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
46631523152.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
46731393139.059.559.5Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
46831363136.077.4277.4Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46931343134.077.7177.7Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
47031343134.0129.37129.4FreeSurfer. Bruce FischlNeuroimage201222248573No
47131303130.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
47231293129.064.9965.0CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
47331283128.063.1263.1STATs and gene regulation. J E DarnellScience19979287210No
47462483124.00.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
47531243124.081.4681.5The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
47631233123.068.968.9Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
47762463123.0138.4369.2Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
47893643121.3243.9481.3Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
47930983098.089.9489.9Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
48061933096.5155.8177.9The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
48130943094.076.576.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
48230933093.075.5175.5Photoelectrochemical cells. M GrätzelNature200111713540Yes
48330893089.077.9177.9The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
48430883088.073.4673.5WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
48530813081.079.0179.0How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
48630773077.085.2785.3Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
48730763076.081.0881.1Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
48830623062.083.8683.9Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
48991723057.3313.31104.4Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
490121533038.2425.66106.4A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
49130333033.062.4862.5The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
49260653032.5146.7873.4Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
493271973021.9742.6982.5The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
49460433021.5224.81112.4Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
49560283014.0162.181.0Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
49630133013.070.7470.7Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
49730033003.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
49830023002.097.1397.1Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
49930013001.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
50029962996.089.5289.5Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
50129942994.063.963.9Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
50229882988.00.00.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
50329842984.065.3265.3Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
50429842984.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
50529832983.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
50659492974.50.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
50729742974.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
50829732973.092.4692.5Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
50929732973.064.7464.7Protein folding and misfolding. Christopher M DobsonNature200314685248No
51059302965.0130.8565.4Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
51159252962.5125.6762.8Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
51229612961.065.365.3Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
51388422947.3192.4264.1Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
514147092941.8590.01118.0The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
51588202940.0179.8159.9Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
51629382938.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
51758652932.5136.8468.4MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
51829282928.0114.18114.2Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
51929232923.091.1291.1Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
52029222922.069.769.7Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
52158442922.0168.0884.0Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52287552918.3243.981.3Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
52329082908.094.4894.5An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
52429012901.0118.99119.0Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
52529002900.0132.78132.8The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
52657992899.50.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
52728992899.070.6170.6Obesity as a medical problem. P G KopelmanNature200010766250No
52857782889.0105.252.6The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
52928862886.092.4692.5Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
530115422885.5457.7114.4APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
53157682884.0163.8381.9Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
53228802880.063.063.0Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53386372879.0231.9477.3Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
53428782878.071.3771.4Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
53557522876.0149.8874.9Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
53628762876.093.7593.8Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
53786262875.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
53828712871.051.4351.4One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
53928712871.091.5291.5Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
54028682868.055.055.0RNA interference. Gregory J HannonNature200212110901No
54128642864.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
54228622862.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
54357242862.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
544114272856.8281.7270.4Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
54528542854.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
54628532853.060.160.1Principles of CDK regulation. D O MorganNature19957877684No
54728532853.067.7867.8Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
54857052852.50.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
54928512851.099.5599.5The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
55085502850.00.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
55156932846.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
55228402840.074.2274.2Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
55328352835.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
55428332833.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
55528332833.0143.58143.6Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
55656622831.00.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55728312831.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
55828222822.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
55956422821.00.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
56028192819.094.7194.7Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
56156332816.5139.9970.0In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
56256302815.0136.4768.2Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
56356002800.0189.794.8Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
56427952795.084.9885.0Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
56555862793.0153.7276.9The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
56627932793.057.4757.5Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
56755732786.50.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
568111392784.80.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
56927802780.094.0194.0Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
57027772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
57183302776.7207.2669.1TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
57227762776.053.7653.8Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57327752775.079.479.4Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
57427742774.072.4172.4Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
57555382769.0179.1489.6Tissue engineering. R Langer, J P VacantiScience19938493529No
57655362768.0245.31122.7Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
57727642764.0128.51128.5The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
57855262763.0128.2864.1Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
57927622762.061.2661.3Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
58027622762.0104.88104.9You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
58127612761.063.5763.6TGFbeta in Cancer. Joan MassaguéCell200818662538No
58282792759.7435.3145.1Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
58327592759.066.2566.2Structure and function of telomeres. E H BlackburnNature19911708110No
58455112755.5128.1664.1Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
58555072753.5261.32130.7phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
58655052752.5186.6793.3The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
58755002750.0127.3263.7Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
58854962748.0109.2854.6High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
58927442744.089.5389.5No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
59027432743.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
59127402740.052.4352.4Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
59282192739.7178.6559.6Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
59354752737.5238.06119.0The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
59427312731.0148.0148.0Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
59527302730.066.5566.5Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
596109202730.0362.490.6Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
59727282728.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
59827232723.078.5378.5RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
59981662722.0272.8490.9Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60027212721.064.4664.5Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
60154312715.5177.5488.8mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
60227122712.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
60327072707.083.9684.0Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
60454092704.50.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
60554082704.0129.0864.5Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
60627042704.069.4269.4The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
60781052701.7208.7869.6MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
60826992699.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
60926962696.083.183.1Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
61053892694.5140.2770.1Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
61153852692.5155.577.8The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
61226802680.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
61353602680.0133.0766.5Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
61453602680.0116.8758.4Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
61553492674.5167.9884.0Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
61653452672.5165.7582.9Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
61726712671.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
61826712671.060.1260.1Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
61953342667.0197.5398.8FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
62053222661.0189.9695.0A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
62126592659.055.0555.0Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
62226582658.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
62379672655.7184.5361.5The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62453072653.5109.4954.7Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
62552992649.50.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
62626492649.046.546.5Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
62752972648.5166.4983.2Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
628211732646.6475.359.4The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
62979302643.3234.478.1Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
63026372637.054.2154.2Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
631105332633.2229.6657.4Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
63226332633.085.1785.2Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
63326302630.053.4853.5The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
63426242624.060.7260.7Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
63526232623.060.2660.3Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
63652392619.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
63726182618.098.2298.2Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
63852352617.5192.2496.1Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
63926162616.071.2471.2Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
64052142607.0107.3953.7Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
64152122606.0174.2587.1Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
64226062606.076.7176.7A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
64326052605.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64426042604.082.5182.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
64526032603.052.3152.3Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
64652042602.0183.5291.8A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
64726002600.0120.86120.9Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
64851992599.50.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
64951962598.0117.658.8Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
65025952595.065.1765.2The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
65151902595.0113.2656.6Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
65225922592.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
65325892589.093.2893.3Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
65451702585.00.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
65525832583.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
65625782578.061.4561.5Memory--a century of consolidation. J L McGaughScience200010634773No
65725782578.061.1261.1Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
65851522576.0175.7787.9Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
65925742574.055.8955.9G1 phase progression: cycling on cue. C J SherrCell19947954821No
66025722572.047.6147.6Wnt signaling and cancer. P PolakisGenes Dev200010921899No
66125722572.081.8281.8adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
66225712571.068.3868.4Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
66325702570.081.3681.4What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
66425682568.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
66551302565.00.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
66625632563.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
66725602560.062.5162.5Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
66825592559.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
66925562556.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
67025542554.073.3673.4Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
67125522552.094.194.1What is value in health care? Michael E PorterN Engl J Med201021142528Yes
67225392539.059.1159.1Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
67325392539.099.9199.9The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
67425372537.066.2266.2The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67525352535.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
67650702535.0140.2570.1Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
67750672533.5147.3873.7Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
67825322532.080.3780.4Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
67950612530.5129.464.7Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
68050592529.5159.0279.5The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
681101132528.2308.8377.2Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
68225262526.00.00.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
68375782526.0183.1961.1Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
68425162516.077.6877.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
68525132513.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
68625092509.050.950.9Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
68725062506.055.9355.9Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
68850052502.50.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
68924972497.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
69049932496.5202.81101.4A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
69124952495.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
69224952495.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
69349892494.50.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
69449882494.00.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
69549882494.0160.7980.4Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys Rev B Condens Matter199210001404Yes
69649692484.5238.37119.2GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
69749672483.5122.9261.5Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
69874502483.3146.6648.9Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
69924812481.056.956.9Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
70024792479.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
70124742474.072.4672.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
70224652465.066.9166.9Dominant forces in protein folding. K A DillBiochemistry19902207096No
70324652465.060.0360.0MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
70424652465.058.5558.5Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
70524572457.059.059.0Calcium signaling. David E ClaphamCell200718083096No
70624462446.086.4286.4DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
70748852442.598.8949.4Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
70824412441.055.2555.2Social controls on cell survival and cell death. M C RaffNature19921557121No
70948812440.5161.0280.5The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
71024382438.058.2858.3Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71148742437.0103.6851.8MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
71224372437.057.4557.5Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
71348722436.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
71424312431.061.7961.8Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
71548562428.0118.159.0Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
71648542427.00.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
71796792419.8458.24114.6Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
71848362418.00.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
71924162416.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
72048232411.595.9348.0CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
72172292409.7390.5130.2Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
72248162408.0136.4968.2Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
72324032403.054.854.8Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
72424022402.065.8865.9Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
72524022402.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
72623912391.051.7251.7Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
72747762388.00.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
72895492387.2301.1275.3Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
72923872387.099.4699.5Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
73023872387.064.5164.5The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
73123862386.046.6746.7Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
73223812381.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
73347422371.0202.81101.4Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
73423702370.00.00.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
73523702370.048.5248.5Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
73647382369.0148.4974.2Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73723672367.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
73870992366.3319.48106.5HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
73923612361.068.3168.3Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
74023582358.073.7773.8SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
74170722357.3264.6888.2featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
74223532353.062.0562.0Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
74323532353.057.8457.8Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
74423512351.051.6851.7Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
74546962348.00.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
74623442344.059.3559.4Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
74723302330.086.2886.3Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
74846602330.096.1548.1Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
74946562328.0231.67115.8Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
75046472323.50.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
75169702323.3313.47104.5Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
75223212321.053.6653.7A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
75323192319.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
75446312315.5104.6552.3Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
75523132313.052.1852.2The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
75646252312.5162.6181.3The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
75723112311.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
75846202310.092.2746.1The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
75923082308.058.6158.6Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
76023042304.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
76169032301.0183.161.0ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
762138012300.2329.1354.9Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
76323002300.082.3782.4A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
76422992299.070.0370.0Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
76545972298.593.1546.6Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
76622962296.066.3266.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
76722962296.057.5357.5Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
76822932293.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
76922892289.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
77045762288.0122.7861.4Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
77145742287.00.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
77268612287.00.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
77322852285.051.9151.9Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
77422822282.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
77522822282.048.8448.8Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
77622782278.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
77722772277.045.8245.8SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
77822752275.068.8868.9Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
77922722272.067.1467.1Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
78022702270.049.349.3Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
78122692269.057.0557.0A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
78245342267.086.4443.2A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
78390592264.8311.8178.0A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
78422632263.076.3476.3Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
78522612261.060.1560.1A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
78622582258.066.7466.7Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
78722562256.065.9365.9The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
78845102255.0119.9760.0Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
78922552255.066.3166.3Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
79022542254.0155.5155.5Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
79122522252.071.8371.8Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
79245042252.0147.0773.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
79344972248.596.9748.5New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
79444972248.50.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
79544962248.0103.1251.6A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
79622452245.055.9856.0The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
79744812240.50.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
79844772238.50.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
79922382238.042.6742.7Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
80022352235.049.8449.8Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
80144592229.5135.1767.6Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
80222292229.056.8556.9A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
80344572228.5104.7652.4Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
80444552227.5116.958.5A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
80544552227.5114.7957.4Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
80622262226.055.2955.3Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
80722252225.054.5154.5Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
80822242224.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
80922242224.053.0753.1Mechanisms and genes of cellular suicide. H StellerScience19957878463No
81066712223.7195.7965.3Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
81144472223.599.9150.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
81222232223.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
81344442222.0150.0875.0Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
81422222222.066.0266.0Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
81522212221.042.4242.4Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
81666612220.3153.1451.0The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
81722202220.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
81822192219.061.9261.9Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
81988692217.2249.7362.4GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
82022172217.077.8677.9Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
82122162216.068.5868.6Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
82222152215.053.2553.2Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
82322102210.087.6187.6Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
824198552206.1440.5348.9Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
82522042204.041.4741.5Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
82622042204.050.2650.3A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
82722032203.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
82866072202.3177.959.3RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
82944022201.0198.2999.1Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
83022012201.085.0485.0Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
83121992199.048.0748.1Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
83221982198.064.9164.9Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
83343952197.50.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
83443942197.0120.1560.1Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
83521962196.068.5268.5Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
83643922196.00.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
83721922192.094.6194.6Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
83821912191.058.958.9Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
83921872187.048.648.6The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
84043742187.0128.8464.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
84121862186.041.8341.8Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
84221822182.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
84365402180.0187.7462.6Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
84421772177.061.3361.3Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
84543492174.587.8143.9Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
84621732173.066.1366.1Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
84765172172.3204.8268.3Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
84843442172.0165.6182.8The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
84943442172.095.5447.8Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
85043402170.099.7349.9The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
85143372168.5134.9167.5SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
85243332166.596.2548.1Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
85321632163.081.6581.7Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
85421632163.079.8679.9Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
85521622162.051.5151.5Specification of cerebral cortical areas. P RakicScience19883291116No
85643242162.0109.4754.7Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
85721602160.048.7448.7Chemokines. B J RollinsBlood19979242519No
85821602160.047.3847.4NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
85943162158.0110.9155.5A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
86043142157.0158.9479.5The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
86121552155.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
86243032151.5107.0153.5Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
86342982149.00.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
86421472147.070.0570.0The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
86521472147.099.699.6Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
86621462146.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
86742912145.5113.5456.8The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
86821432143.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
86942862143.0105.9553.0Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
87021422142.041.9441.9Protein modules and signalling networks. T PawsonNature19957531822No
87121402140.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
87242802140.0125.0962.5Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
87342772138.5165.2382.6Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
87421382138.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
87521372137.043.5243.5The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
87621372137.056.7256.7T cell exhaustion. E John WherryNat Immunol201121739672No
87742712135.5110.9855.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
87842712135.599.6349.8AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87942702135.00.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
88042682134.0161.6280.8Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
88142672133.50.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
882170592132.4550.8868.9The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
88321312131.089.3889.4A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
88442572128.5130.1865.1Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
88563832127.7184.3561.4Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
88642512125.5101.4750.7Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
88721252125.071.4671.5Working memory. A BaddeleyScience19921736359No
88842382119.0107.2953.6Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
88942362118.0134.6567.3Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
89042342117.00.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
89121162116.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
89221152115.049.9750.0The inflammatory reflex. Kevin J TraceyNature200212490958No
89321132113.046.9246.9Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89421132113.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
89521122112.050.3550.4Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
89621122112.049.2949.3Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
89721112111.075.8575.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
89821082108.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
89921052105.053.5953.6RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
90042092104.5123.6861.8Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
90121032103.044.8944.9Mammalian G1 cyclins. C J SherrCell19938513492No
90242062103.0114.7157.4UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
90342032101.5120.760.4Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
90442012100.5121.2560.6Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
90521002100.068.1768.2Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
90620952095.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
90762822094.0167.055.7Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
90820942094.053.553.5Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
90920942094.086.4186.4Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
91062792093.0146.0648.7MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
91162762092.00.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
91262762092.0166.4255.5Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
91383652091.2277.0369.3clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
91420902090.054.3754.4Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
91562672089.00.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
91641782089.0107.253.6Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
91720882088.063.9463.9The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
91820872087.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
91941732086.5124.5962.3The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
92062562085.3183.661.2Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
92141672083.5114.257.1Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
92220832083.062.9162.9Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
92320812081.049.1549.1Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
92420802080.068.8168.8Human error: models and management. J ReasonBMJ200010720363Yes
92520802080.046.3746.4Complement. First of two parts. M J WalportN Engl J Med200111287977No
92620792079.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
92720792079.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
92820772077.068.4368.4Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
92920762076.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
93020742074.069.9469.9A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
93120742074.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
93241452072.5104.3552.2Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
93320722072.052.9653.0Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
93420702070.058.3758.4Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
93541402070.00.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
93620672067.057.3257.3The importance of selenium to human health. M P RaymanLancet200010963212No
93720672067.041.941.9Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
93820672067.096.1796.2Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
93920662066.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
94020652065.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
94141272063.587.8243.9A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
94220622062.068.068.0Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
94341212060.5115.857.9A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
94420582058.084.6784.7Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
94561742058.00.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
94620582058.068.1168.1Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
94741162058.081.1840.6The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
948226182056.2490.9744.6Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
94982212055.2323.3480.8Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
95020552055.058.3758.4Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
95120532053.042.9843.0Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
95241042052.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
95320492049.042.9342.9G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
95440962048.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
95520452045.054.7954.8Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
95620442044.083.4483.4A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
95720442044.040.2240.2Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
95820422042.059.859.8ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
95920422042.063.3963.4A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
96020392039.054.4554.5The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
96140632031.5100.0650.0Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
96220312031.068.0368.0The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
96320302030.048.2148.2Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
96420292029.063.0263.0Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
96581092027.2183.1345.8Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
96620262026.068.6368.6Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
96720212021.053.3153.3The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
96820212021.058.2858.3Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
96920212021.066.8266.8Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
97020202020.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
97120202020.065.9465.9Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
97220182018.047.8947.9Calcium signaling. D E ClaphamCell19957834745No
97320182018.039.6639.7NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
97440342017.0113.4956.7Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
97520162016.069.5369.5Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
97640312015.5106.2653.1The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
97720152015.065.8165.8Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
97820152015.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
97940282014.081.1440.6Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
98020142014.044.6444.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
98140242012.0110.0355.0New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
98240242012.0105.6952.8Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
98320122012.053.353.3Descending control of pain. Mark J MillanProg Neurobiol200212034378No
98420122012.055.8755.9The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
98540212010.50.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
98620102010.051.2451.2Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
98720102010.047.5447.5Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
98840112005.5101.6850.8Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
98920052005.050.1450.1Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
99020002000.042.442.4XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
99119991999.042.3342.3Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
99299931998.61006.3201.3MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
99339961998.0129.564.8A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
99439951997.581.7740.9Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
99519951995.058.6158.6Protein oxidation and aging. E R StadtmanScience19921355616No
99659851995.0118.0739.4Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
997119621993.7271.6245.3NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
99819931993.00.00.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
99919931993.085.485.4Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
100019911991.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
100139811990.598.549.2Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
100239761988.00.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
1003178641984.91006.93111.9Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
100419821982.054.1154.1Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
100519801980.083.7183.7The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
100619771977.070.9370.9Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
100719761976.056.4956.5Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
100819751975.055.355.3The episodic buffer: a new component of working memory? BaddeleyTrends Cogn Sci200011058819Yes
100919751975.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
101039491974.592.7546.4Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
101119721972.066.4666.5Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
101219701970.045.4645.5A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
101319691969.059.8159.8Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
101478731968.2200.8550.2Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
101519681968.053.4553.5Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
101619681968.072.3772.4International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
101719661966.040.9941.0Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
101839311965.579.7539.9Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
101939291964.5181.3790.7Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
102019631963.087.4487.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
102119611961.048.148.1Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
102239211960.593.7646.9Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
1023117491958.2397.8766.3Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
102458741958.0121.7240.6Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
102519571957.078.3578.3Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
102619551955.035.4135.4ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
102719541954.054.654.6The biology of interleukin-6. T KishimotoBlood19892473791No
102819541954.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
102939031951.585.2842.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
103058521950.7196.5465.5Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
103119491949.039.439.4CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
103219481948.051.1851.2A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
103319471947.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
103438941947.085.5142.8The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
103558391946.3224.9675.0Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
103619451945.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
103719451945.035.9536.0In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
103838851942.50.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
103919421942.058.1758.2Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
104019421942.051.2951.3Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
104138811940.5108.2954.1Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
104238811940.598.5549.3Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
104319401940.040.6840.7Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
104438721936.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
104519361936.040.7840.8Molecular bases for circadian clocks. J C DunlapCell19999988221No
104638711935.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
104719351935.081.8581.8A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
104838701935.079.1139.6Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
104919351935.075.0275.0Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
105019331933.044.0944.1Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
105119331933.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
105219311931.065.4165.4Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
105338601930.0109.2554.6Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys Rev B Condens Matter199410010505Yes
105438561928.095.547.8Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
105538561928.078.9239.5Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
105619271927.043.1643.2Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
105719271927.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
105857761925.3187.5262.5FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
105919241924.042.5842.6Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
106019241924.050.6950.7Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
106119231923.060.1960.2TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
106219221922.040.6840.7A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
106338431921.50.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
106438421921.0174.5787.3The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
106519191919.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
106638371918.596.3548.2Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
106719181918.052.7252.7The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
106838351917.5144.0572.0The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
106938321916.0103.9352.0Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
107019151915.051.3451.3DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
107119141914.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
107219141914.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
107338281914.0116.6158.3Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
107419121912.047.2247.2DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
107519121912.043.3643.4Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
107638221911.097.4448.7Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
107719101910.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
107819101910.055.4155.4Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
107938191909.577.638.8The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
108057281909.3144.6848.2GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
108119091909.034.9234.9Signaling--2000 and beyond. T HunterCell200010647936No
108219091909.048.2748.3Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
108357271909.0180.8760.3The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
108438171908.596.7148.4Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
108538161908.089.9745.0Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
108638081904.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
108719021902.049.1649.2Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
108819021902.041.7841.8The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
108919021902.038.638.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
109019011901.057.2257.2Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
109119001900.084.1484.1Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
109219001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
109319001900.050.0150.0Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109418951895.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
109537861893.00.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
109618921892.063.7363.7The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
109756761892.0119.7539.9EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
109875641891.0189.347.3p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
109937811890.50.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
110018901890.058.1158.1Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
110118881888.050.9250.9The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
110256631887.70.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
110318861886.052.8152.8Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
110437701885.0123.1561.6Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
110518841884.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
110637681884.0109.0754.5Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
110737681884.088.9844.5The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
110818841884.039.3239.3The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
110918841884.055.0555.0Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
111056481882.7183.3661.1Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
111137651882.50.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
111256461882.0161.5153.8Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
111356461882.0181.8360.6Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
111475271881.8252.063.0Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
111537601880.086.8543.4The Fas death factor. S Nagata, P GolsteinScience19957533326No
111618771877.034.0634.1The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
111756281876.0138.3246.1APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
111818711871.054.5154.5Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
111918671867.045.9345.9Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
112037341867.096.9548.5Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
112118671867.037.6437.6Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
112218661866.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
112318661866.090.9991.0Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
112418661866.037.9838.0DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
112518651865.046.1946.2DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
112674541863.5157.5239.4WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
112737261863.085.142.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
112837251862.580.3540.2Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
112918621862.058.3858.4The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
113018601860.040.6440.6The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
113118591859.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
113237181859.073.0136.5Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
113318591859.039.6239.6Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
113418561856.053.1653.2MYC on the path to cancer. Chi V DangCell201222464321No
113518551855.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
113618551855.054.1354.1The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
113718551855.047.6147.6Negative refraction makes a perfect lens PendryPhys Rev Lett200011041972Yes
113818551855.047.1847.2Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
113918551855.037.3237.3Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
114037071853.592.9846.5Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
114118531853.040.4940.5TRP channels as cellular sensors. David E ClaphamNature200314654832No
114237011850.5164.0282.0The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
114318501850.0100.56100.6The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
114418491849.0107.22107.2Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
114573921848.0282.3570.6The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114636961848.089.9545.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
114718471847.049.149.1Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
114836941847.094.6847.3The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
114918461846.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
115018461846.046.146.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
115155381846.0211.2570.4Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
115255321844.00.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
115355311843.7183.161.0AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
115436871843.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
115573671841.8256.964.2Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
115618411841.044.3544.4Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
115718391839.059.7559.8Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
115818371837.059.6859.7Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
115918371837.045.5145.5The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
116018351835.046.8646.9Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
116118351835.039.039.0The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
116218341834.061.6461.6Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
116318331833.051.6351.6Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
116418321832.057.4657.5PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
116536621831.00.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
116618311831.049.349.3Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
116773231830.80.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
116818291829.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
116973161829.0289.5172.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
117018281828.068.3368.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
117118271827.041.1841.2Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
117218271827.046.8146.8Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
1173146041825.5414.6351.8Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
117418251825.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
117572941823.50.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
117618231823.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
117754641821.3105.8335.3Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
117818211821.050.3250.3A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
117954621820.7138.2646.1Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
118018201820.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
118172701817.5287.4471.9A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
118218171817.052.2152.2Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
118318171817.040.6340.6A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
118418171817.033.2433.2Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
118572611815.2178.5544.6Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
1186127041814.9288.8941.3Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
118754441814.7125.5641.9A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
118836291814.5158.7579.4The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
118918141814.041.6541.6DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
119018141814.043.3743.4Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
119118131813.040.7840.8The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
119218131813.035.935.9Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
119318121812.044.8744.9The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
119436231811.5125.7262.9Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
119518101810.039.6339.6Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
119618091809.041.4341.4Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
119718081808.041.9942.0Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
119818071807.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
119918071807.048.6548.6An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
120018061806.067.8367.8Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
120136101805.0120.2660.1Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
120236101805.0123.7361.9Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
120336081804.0102.251.1The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
120418031803.037.0537.0Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
120518031803.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
120636041802.0129.8364.9Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
120718011801.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
120836021801.075.2737.6Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
120972021800.5177.2644.3Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
121017991799.061.8361.8Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
121117981798.045.7145.7The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
121217971797.066.066.0Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
121317971797.043.5543.5The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
121417961796.047.1247.1Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
121517941794.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
121617941794.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
121717931793.073.0573.0Perception of risk. P SlovicScience19873563507Yes
121817931793.058.2558.2Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
121935861793.0114.4257.2Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys Rev B Condens Matter19919997467Yes
122035841792.0114.6857.3Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
1221161251791.7570.6963.4STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
122235831791.599.7249.9ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
122317911791.045.5445.5Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
122417881788.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
122517871787.058.9458.9Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
122617871787.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
122753591786.3177.959.3Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
122817861786.043.3443.3Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
122917851785.053.6653.7Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
123017831783.035.5235.5Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
123117831783.045.3945.4Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
123217811781.058.6758.7Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
123317801780.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
123417801780.085.6885.7Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
123535591779.50.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
123635591779.567.2233.6Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
123735591779.593.7146.9A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
123835581779.00.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
1239124491778.4302.1843.2Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
124017781778.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
124117771777.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
124217771777.051.5951.6Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
124335531776.593.9247.0Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
124417761776.057.1557.1Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
124553271775.7139.2146.4Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
124617741774.049.6949.7New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
124735471773.586.4143.2Protein folding in the cell. M J Gething, J SambrookNature19921731198No
124817731773.092.9392.9Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
124917691769.052.8252.8Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys Rev Lett198710034639Yes
125017671767.037.4537.5Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
125117671767.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
125217651765.081.7581.8Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
125317651765.036.736.7DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
125435221761.094.0647.0Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
125517601760.054.6454.6An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
125617581758.048.1148.1G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
125717571757.062.2762.3The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
125817571757.061.9562.0Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
125917551755.062.3562.4A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
126017551755.036.5636.6An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
1261122841754.9553.1779.0limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
126235081754.076.138.0Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
126317531753.068.5368.5Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
126417531753.046.4546.5What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
126517531753.056.9557.0Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
126617531753.046.5746.6P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
126717521752.058.9258.9Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
126817511751.065.2865.3Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
126917511751.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
127017511751.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
127117511751.067.6867.7The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
127234971748.597.2848.6Building better batteries. M Armand, J-M TarasconNature200818256660No
127317481748.040.3940.4Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
127417451745.045.0445.0The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
127517451745.046.5946.6Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
127617451745.036.136.1MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
127734881744.083.6241.8Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
127834861743.00.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
127917431743.043.0243.0Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
128017421742.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
128117421742.041.6941.7Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
128234781739.073.9837.0Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
128334741737.088.4444.2The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
128417361736.039.0839.1The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
128517361736.036.5836.6Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
128617361736.040.5340.5Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
128752051735.0118.2839.4Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
128817351735.035.2335.2Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
128917331733.055.2755.3Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
129051991733.0101.433.8Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
129117321732.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
129217321732.074.4774.5KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
129317311731.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
129434601730.093.7846.9Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
129517301730.038.0138.0Exploring complex networks. S H StrogatzNature200111258382No
129651871729.0113.4337.8Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
129717281728.062.2562.2Cyclosporine. B D KahanN Engl J Med19892687689No
129817271727.043.1443.1Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
129917271727.050.650.6Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
130017241724.036.4236.4Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
130134451722.583.0441.5PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
130234441722.093.9647.0Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
130317221722.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
130417221722.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
130517211721.057.0157.0Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
130617201720.058.2958.3Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
130717201720.032.1532.1CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
130817191719.069.0469.0Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
130934381719.0126.1463.1Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
131034381719.0100.0250.0The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
131168741718.5134.5733.6Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
131217181718.041.8241.8Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
131334351717.591.2245.6Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
131468701717.5180.6245.2Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
131517171717.047.6347.6Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
1316120151716.4438.5362.6Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
131751481716.0232.2977.4Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
131817161716.041.4141.4Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
131917151715.053.8453.8The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
132017151715.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
132134301715.00.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
132217151715.052.5752.6Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
132334281714.086.2643.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
132485701714.0233.3846.7Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
132534271713.575.7937.9Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
132617111711.057.2557.2The crisis in antibiotic resistance. H C NeuScience19921509257No
132717101710.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
132817101710.056.8256.8Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
132934181709.00.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
133017091709.054.4454.4Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
133117081708.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
133217081708.044.5544.5The genetics of ageing. Cynthia J KenyonNature201020336132No
1333170731707.3541.5254.2Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
133417071707.045.4645.5Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
133517061706.073.3373.3Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
133617051705.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
133717051705.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
133834091704.567.7533.9SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
133917041704.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
134017041704.048.4948.5Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
134117041704.046.8146.8The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
134268151703.8178.4744.6Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
134334071703.578.7939.4Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
134434061703.0116.0358.0Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
134534051702.578.6939.3Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
134617011701.057.457.4Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
134717011701.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
134816991699.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
134916981698.031.9131.9How eukaryotic transcriptional activators work. M PtashneNature19883050531No
135016981698.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
135116981698.044.7844.8Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
135216981698.047.147.1Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
135316981698.035.5235.5The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
135433951697.578.3839.2Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
135516971697.053.6753.7Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
135616971697.057.5457.5Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
135716961696.045.8445.8Integrins. E RuoslahtiJ Clin Invest19911985087No
135833921696.00.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
135916961696.040.1240.1Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
136016961696.063.9564.0Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
136133911695.50.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
136216931693.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
136316921692.057.1457.1Serum albumin. T PetersAdv Protein Chem19853904348No
136416911691.081.8181.8The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
136516901690.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
136633791689.5101.1750.6Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
136716891689.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
136816881688.040.7540.8The molecular genetics of cancer. J M BishopScience19873541204No
136984321686.4214.2442.8Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
137016861686.058.9759.0Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
137133721686.072.4736.2Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
137267301682.50.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
137333651682.594.2447.1Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
137433641682.086.1343.1Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
137516811681.032.332.3Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
137667221680.5135.9434.0Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
137716791679.061.0761.1Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
137833561678.094.7347.4Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
137916781678.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
138016731673.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
138116721672.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
138283561671.2205.3141.1Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
138316711671.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
138416701670.045.9145.9Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
138516701670.049.2749.3Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
138633391669.50.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
138716691669.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
138833381669.00.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
138916691669.058.3358.3Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
139016691669.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
139133381669.0136.8768.4miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
139233371668.50.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
139316681668.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
139416681668.041.541.5Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
139533351667.5104.0852.0Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
139616661666.038.8538.9The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
139716661666.045.2645.3Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
139816651665.037.8937.9Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
139916651665.048.0748.1Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
140033291664.581.1140.6Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
140166551663.8303.2975.8jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
140216621662.00.00.0The micronucleus test. W SchmidMutat Res197548190Yes
140316621662.039.8939.9The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
140433221661.0145.2472.6A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
140533201660.00.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
140649801660.0158.1152.7Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
140716601660.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
140833201660.0131.0265.5Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
140916601660.046.8746.9Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
141016581658.038.8438.8Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
1411165681656.8530.8553.1The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
141216561656.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
141333111655.586.1343.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
141416551655.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
141516551655.036.2536.2Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
141633101655.0108.754.4Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
141766191654.8324.3781.1The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
141833091654.5109.6954.8Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
141949631654.3152.2350.7Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
142066131653.2153.7938.4Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
142116521652.048.9949.0Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
142233011650.584.3942.2Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
1423132041650.5340.8642.6Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
142433011650.587.9844.0Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
142532971648.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
142616481648.070.7670.8The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
142732951647.588.7244.4Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
1428115281646.9291.6341.7Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
142916461646.068.4168.4Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
143016451645.040.6340.6Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
143116451645.034.534.5Points of control in inflammation. Carl NathanNature200212490957No
143216451645.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
143332891644.5120.4660.2ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
143432891644.590.4545.2The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
143532881644.00.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
143616431643.052.5952.6Metallothionein. D H HamerAnnu Rev Biochem19863527054No
143716431643.035.3935.4Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
143832851642.50.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
143932841642.078.9339.5The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
144016421642.038.5138.5NADPH oxidase: an update. B M BabiorBlood199910029572No
144116421642.045.9946.0Leptospirosis. P N LevettClin Microbiol Rev200111292640No
144232841642.078.6539.3The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
144398491641.5281.7547.0Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
144432831641.595.0847.5Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
144516411641.045.8145.8Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
144616401640.032.4932.5Hox genes in vertebrate development. R KrumlaufCell19947913880No
144716401640.040.0440.0Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
144816391639.043.8243.8From sensation to cognition. M M MesulamBrain19989648540No
144932781639.071.7735.9Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
145016391639.053.7953.8A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
145116381638.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
145216381638.032.4132.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
145316371637.038.1838.2Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
145416361636.035.0435.0Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
145516341634.090.090.0Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
145616331633.039.5239.5The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
145716331633.045.3845.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
145816311631.041.2141.2Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
145948911630.3105.3135.1A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
146048911630.3114.8638.3Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
146116301630.030.530.5Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
146216291629.047.4847.5Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
146332561628.071.4935.7Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
146416271627.041.8841.9Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
146516271627.050.850.8A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
146616271627.039.7939.8Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
146716271627.046.1546.1Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
146816261626.049.1849.2Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
146916261626.042.2342.2Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
147016261626.097.9998.0The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
147116251625.058.7158.7Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
147264941623.5145.0736.3MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
147316221622.070.9270.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
147416221622.063.4863.5Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
147516221622.063.0463.0Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
147648661622.0134.3444.8The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
147732431621.579.3639.7CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
147816211621.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
147916211621.052.0752.1The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
148016191619.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
148116191619.032.9933.0Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
148216191619.068.4368.4The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
148316181618.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
148416181618.032.9933.0The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
148516181618.040.2540.2Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
148616161616.033.4633.5Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
148716151615.032.0832.1Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
148816141614.043.3443.3Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
148916131613.048.7848.8Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
149016131613.059.659.6Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
149116121612.050.850.8Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
149216121612.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
149316111611.046.7746.8Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
149416101610.037.037.0Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
149516101610.029.5429.5Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
149616101610.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
149732191609.577.5138.8Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
149816091609.042.2742.3Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
149916091609.047.3147.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
150016091609.035.0435.0Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
150148261608.7106.3735.5Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
150232171608.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
150332171608.5104.7252.4Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
1504176921608.4466.5642.4PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
150516071607.054.0854.1Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
150616041604.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
150732071603.5125.9463.0The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
150832051602.568.0134.0A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
150916021602.036.9937.0VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
151096081601.3293.2448.9Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
151164051601.2347.4786.9IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
151216001600.040.6240.6Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151316001600.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
151447991599.7128.9243.0Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
151547991599.7108.0936.0An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
151631991599.563.6631.8Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
151715991599.047.2447.2Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
151815981598.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
151915981598.034.5834.6The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
152015971597.031.131.1Switching and signaling at the telomere. E H BlackburnCell200111572773No
152131931596.581.5440.8Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
152231921596.0113.8256.9Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
152347861595.3192.264.1The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
152431901595.062.9131.5Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
152515941594.039.9439.9Tumor necrosis factor (TNF). L J OldScience19852413547Yes
152615941594.045.9445.9Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
152715931593.00.00.0The inverse care law. J T HartLancet19714100731Yes
152815931593.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
152915931593.040.0240.0Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
153015921592.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
153115911591.031.6531.6An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
153215911591.049.6949.7Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
153315911591.040.2440.2Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
153415901590.045.7545.8Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
153531791589.568.0734.0Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
153631791589.572.0336.0The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
153715891589.055.855.8Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
153815881588.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
153931761588.096.1348.1Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
154047591586.3136.9545.6Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
154115861586.045.7945.8The in vitro micronucleus technique. M FenechMutat Res200011113469No
154215861586.043.0143.0THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
154315861586.037.3937.4The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
154415851585.052.8552.9Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
154515851585.072.4372.4Mood and memory. G H BowerAm Psychol19817224324Yes
154615851585.030.3230.3Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
154747541584.70.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
154831691584.5210.62105.3A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
154931681584.0104.3752.2Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
155015831583.057.4357.4Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
155131651582.578.4139.2A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
155231651582.5100.7650.4Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
155315821582.034.5634.6Neuronal calcium signaling. M J BerridgeNeuron19989697848No
155431631581.588.9944.5Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
155579061581.2204.5640.9Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
155615801580.034.634.6On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
155731601580.0164.6582.3Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
155815801580.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
155931561578.097.8248.9Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
156015781578.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
156115781578.036.4436.4AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
156215781578.054.5454.5Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
156347291576.3158.3452.8Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
156447271575.7134.7144.9Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
156515751575.040.7940.8Molecular biology of prion diseases. S B PrusinerScience19911675487No
156631501575.069.1334.6Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
156731501575.071.6835.8Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
156815751575.036.2836.3Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
156915751575.044.9545.0What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
157031491574.50.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
157115741574.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
157215741574.050.8150.8Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
157315741574.041.9742.0Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
157415731573.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
157515731573.027.7227.7Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
157615721572.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
157715721572.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
157894281571.3198.4333.1Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
157915711571.052.4152.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
158015711571.035.7235.7The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
158162821570.5229.5557.4SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
158231391569.597.7148.9Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
158315691569.048.9949.0Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
158415691569.054.8154.8Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
158515661566.045.8145.8The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
158615661566.033.3133.3Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
158715661566.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
158893801563.3221.3136.9Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
158931241562.091.545.8Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
159031241562.076.0538.0Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
159115621562.039.4139.4Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
159215621562.056.8156.8Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
159315611561.045.2845.3Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
159415611561.042.8442.8The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
159531221561.076.8438.4The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
159615601560.066.9967.0A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
159731201560.064.8932.4Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
159815591559.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
159915581558.041.841.8Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
160015581558.038.1138.1HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
160115581558.039.3939.4Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
160215581558.031.231.2Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
160331161558.075.1837.6Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
160415561556.051.651.6Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
160515561556.036.7236.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
160615551555.066.1166.1Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
160746631554.3117.2839.1Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
160815541554.060.2460.2Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
160915541554.070.9671.0The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
161093231553.8323.9654.0Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
161146601553.3118.5839.5Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
161277621552.4178.2835.7Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
161331041552.081.8340.9Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
161415511551.028.4328.4Altering the genome by homologous recombination. M R CapecchiScience19892660260No
161515501550.057.5957.6The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
161615501550.030.4530.4Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
161746491549.70.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
161815491549.057.9257.9Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
161915471547.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
162046401546.7103.9134.6Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
162146401546.7147.8749.3Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
162230931546.565.9733.0Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
162315461546.071.2871.3Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
162415461546.036.5636.6Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
162530921546.074.1537.1Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
162630911545.5112.3656.2The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
162715451545.045.145.1The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
162815451545.029.4429.4How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
162915441544.060.6560.6Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
163015431543.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
163115431543.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
163230841542.094.3147.2Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
163315421542.063.2563.2Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
163415411541.036.3436.3Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
163515411541.071.7771.8What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
163615401540.030.6930.7The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
163730791539.50.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
163815391539.050.2650.3Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
163915381538.083.1683.2Subjective well-being. E DienerPsychol Bull19846399758No
164015381538.037.9137.9Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
164115381538.049.1149.1Social relationships and health. Sheldon CohenAm Psychol200415554821No
164230751537.50.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
164330751537.50.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
164430741537.00.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
164530731536.560.8130.4Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
164676821536.40.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
164715361536.034.6434.6Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
164830721536.0103.3551.7The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
164930721536.063.9232.0Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
165015351535.037.1537.1A revolution in optical manipulation. David G GrierNature200312917694No
165115351535.035.4335.4Perceptions of epigenetics. Adrian BirdNature200717522671Yes
165215341534.030.7330.7E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
165346021534.0120.4340.1The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
165415341534.044.4144.4Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
165515341534.032.5532.5DNA in a material world. Nadrian C SeemanNature200312540916No
165615341534.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
165730681534.0127.7563.9Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
165830671533.50.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
165945971532.3157.3152.4A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
166015321532.039.1139.1Early signals in the mitogenic response. E RozengurtScience19863018928No
166130621531.089.0344.5The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
166230611530.593.0146.5Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys Rev Lett198510032153Yes
166315301530.035.5335.5Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
166415301530.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
166515291529.047.9447.9The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
166615291529.034.2134.2Molecular themes in oncogenesis. J M BishopCell19911988146No
166715291529.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
166845851528.392.0730.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
166915281528.038.638.6The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
167030551527.572.8936.4The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
167115271527.00.00.0Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
167261081527.00.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
167315271527.031.2831.3The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
167415271527.033.933.9Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
167515261526.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
167615261526.045.545.5Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
167730511525.50.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
167845761525.3123.0341.0A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
167915251525.032.3332.3Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
168015241524.045.8645.9Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
168130471523.584.5842.3Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
168230441522.0115.2257.6Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
168315211521.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
168430421521.095.2347.6Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
168515201520.00.00.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
168615201520.041.5941.6Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
168715201520.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
168815201520.045.8745.9Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
168930381519.0116.5558.3The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
169015191519.039.9740.0Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
169115161516.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
169215161516.035.7735.8A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
169315161516.038.7438.7Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
169415161516.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
169515161516.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
169615141514.038.3338.3Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
169760561514.0151.9638.0Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
169815131513.038.8138.8Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
169915131513.054.8254.8Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
170015121512.042.4342.4Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
170115121512.042.0542.0Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
170245351511.7185.3861.8Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
170345291509.791.1330.4Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
170430171508.574.6237.3Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
170515081508.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
170660311507.8175.2143.8Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
170760301507.5243.7760.916S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
170815071507.040.4240.4Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
170960181504.5176.5744.1Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
171015041504.054.2554.2Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
171115041504.035.2335.2PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
171215031503.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
171330051502.5103.8151.9Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
171415021502.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
171515021502.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
171630011500.587.7543.9EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
171715001500.049.8549.9Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
171815001500.036.4336.4In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
171914991499.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
172029961498.0110.0755.0Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
172114981498.051.2551.2Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
172244931497.795.932.0The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
172344911497.085.7228.6Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
172429941497.0118.8759.4Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
172514961496.029.2729.3Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
172629921496.00.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
172714941494.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
172814941494.033.4233.4An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
172929881494.067.1633.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
173014931493.039.339.3The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
173129861493.060.9330.5NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
173244761492.0125.3341.8Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
173329841492.00.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
173414901490.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
173514901490.025.5525.6Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
173614891489.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
173714891489.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
173814891489.042.7442.7Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
173914871487.052.0852.1Lyme disease. A C SteereN Engl J Med19892668764No
174029731486.556.7628.4The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
174129721486.066.533.2Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
174214851485.029.3229.3Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
174359401485.0248.6262.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
174429691484.584.7442.4Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
174529691484.5103.451.7Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
174629691484.5104.4852.2Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
174744511483.7151.5350.5Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
174829671483.50.00.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
174929671483.559.5929.8Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
175029671483.588.2144.1An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
175159331483.20.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
175214831483.033.6133.6Tumor suppressor genes. R A WeinbergScience19911659741No
175314831483.054.1454.1The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
175414831483.040.0740.1Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
175514831483.033.6433.6Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
175614831483.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
1757148251482.5363.5336.4Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
175814821482.031.8231.8Drug discovery: a historical perspective. J DrewsScience200010720314No
175914821482.032.432.4From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
176014811481.035.5835.6Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
176144421480.7110.3936.8Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
176214801480.047.247.2Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
176314801480.067.9868.0The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
176414801480.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
176514801480.037.3237.3The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
176614791479.055.6355.6UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
176714791479.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
176814791479.055.8155.8Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
176914781478.044.0744.1Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
177029551477.556.9828.5Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
177114771477.049.4149.4Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
177214771477.034.7234.7Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
177314771477.039.6139.6External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
177488611476.8289.9248.3New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
177559051476.2254.4663.6An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
177644291476.3147.9449.3Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
177714761476.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
177829521476.0110.3855.2The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
177914761476.035.4535.5Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
178014761476.029.6529.6Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
178129511475.5104.9952.5The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
178244261475.30.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
178314751475.037.6637.7Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
178414751475.029.729.7Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
178514751475.029.029.0Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
178614741474.046.0646.1Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
178714731473.033.7733.8Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
178829461473.080.0740.0Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
178914731473.033.633.6The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
179029451472.563.2631.6Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
179114721472.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
179214721472.039.9139.9Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
179358881472.0175.8244.0The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
179414721472.051.6551.6Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
179529431471.563.3331.7The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
179629431471.568.934.5The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
179714711471.044.7344.7Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
179814711471.036.4636.5Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
179914701470.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
180014701470.030.4230.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
180129381469.061.1130.6Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
180258751468.8119.8430.0A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
180329371468.557.8528.9Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
180429371468.561.2130.6The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
180514681468.040.740.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
180614681468.030.5530.6Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
180729361468.081.1340.6Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
180844031467.70.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
180914671467.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
181029321466.00.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
181114651465.060.7960.8Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
181214651465.050.6350.6The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
181329261463.056.0328.0Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
181414631463.036.9837.0The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
181558491462.20.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
181614621462.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
181714621462.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
181829231461.576.8338.4The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
181929221461.076.238.1Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
182087611460.2276.1946.0Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
182114601460.046.9246.9The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
182214591459.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
182314591459.045.2745.3Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
182414591459.044.5444.5The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
182514581458.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
182614581458.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
182729141457.068.634.3A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
182814571457.027.927.9Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
182914571457.035.5335.5The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
183029121456.095.447.7Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
183114561456.033.933.9Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
183214551455.060.8860.9Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
183314551455.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
183429091454.50.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
183514541454.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
183614531453.043.143.1Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
183714531453.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
183829041452.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
183929041452.077.1638.6Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
184014501450.00.00.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
184114501450.041.941.9Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
184214501450.035.7935.8Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
184372481449.6150.3130.1Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
184428991449.568.1934.1Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
184514491449.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
184628981449.084.4242.2Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
184714481448.048.6848.7Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
184828961448.091.3445.7Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
184928951447.559.9530.0Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
185028941447.00.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
185114471447.034.5234.5Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
185228941447.080.4340.2A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
185314471447.045.7845.8Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
185472341446.8304.6560.9UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
185557861446.50.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
185614461446.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
185728921446.0119.6759.8Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
185814461446.025.9425.9Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
1859130051445.0406.0445.1The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
186028901445.065.3332.7Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
186128891444.573.636.8Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
186214441444.041.5141.5n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
186328861443.00.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
186414431443.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
186528841442.00.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
186628841442.00.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
186728831441.564.6532.3Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
186814411441.027.4427.4Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
186943231441.00.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
187014391439.037.6937.7Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
187114391439.034.934.9Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
187214391439.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
187328761438.072.3736.2Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
187414381438.037.737.7Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
187514371437.034.134.1PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
187614371437.039.0139.0Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
187714371437.035.8835.9Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
187814371437.032.9933.0Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
187914371437.032.4932.5Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
188028711435.561.2430.6Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
188143061435.3106.1935.4Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
188228691434.578.9539.5Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
188314341434.033.833.8Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
188428671433.50.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
188528671433.565.5732.8How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
188614331433.046.4546.5Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
188728661433.060.3430.2Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
188828661433.066.1333.1Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
188914331433.033.0933.1Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
189028661433.060.6830.3Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
189114331433.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
189242981432.7112.637.5Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
189328641432.069.1134.6Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
189414321432.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
189514321432.029.6229.6RNA silencing in plants. David BaulcombeNature200415372043No
189614311431.027.7427.7Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
189714301430.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
189814301430.046.3146.3Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
189914281428.033.1133.1The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
190014281428.033.0733.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
190114271427.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
190214271427.035.4735.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
190314271427.072.8672.9Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
190414251425.038.4638.5A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
190528491424.564.4432.2Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
190614231423.057.857.8A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
190728451422.594.3847.2The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
190842651421.7122.5540.9The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
190914211421.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
191014211421.051.9652.0Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
191142591419.793.431.1NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
191228381419.074.1637.1Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
191314191419.059.2559.2Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
191414181418.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
191528361418.066.5633.3The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
191614181418.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
191714171417.058.4558.5Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
191814171417.042.5742.6Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
191914161416.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
192014161416.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
192128301415.085.642.8The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
192228301415.056.3428.2The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
192328291414.559.6129.8A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
192428291414.586.1743.1A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
192528291414.585.8442.9Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
192628281414.081.0440.5Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
192728271413.50.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
192814131413.031.6931.7Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
192928231411.573.937.0Obesity. David W Haslam, W Philip T JamesLancet200516198769No
193014111411.031.431.4Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
193114111411.036.8836.9Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
193214111411.049.5349.5The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
193328201410.089.7544.9Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
193414101410.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
193528201410.086.1643.1Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
193628201410.086.743.4Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
193728191409.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
193828171408.563.1431.6Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
193928171408.563.5531.8Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
1940225341408.4806.1550.4Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
194114081408.00.00.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
194214061406.039.1939.2A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
194314061406.029.6729.7The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
194414051405.037.1237.1The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
194514051405.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
194628091404.593.3746.7The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
194714041404.035.8235.8An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
194814041404.036.8736.9Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
194970191403.8152.9130.6Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
195098251403.6217.0131.0Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
195128051402.586.1743.1Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
195228051402.50.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
195328051402.5101.5650.8Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
195414021402.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
195528041402.064.0532.0NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195628031401.50.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
195728031401.5112.2456.1Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
195828031401.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
195956051401.2147.0736.8Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
196014011401.032.1532.1The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
196114011401.039.9540.0Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
196256031400.8126.2631.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
196314001400.037.6237.6Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
196413991399.033.1633.2Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
196513991399.034.1534.1Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
196613991399.028.3528.4Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
196727981399.00.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
196813981398.030.2130.2Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
196941941398.098.3232.8Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
197041931397.7141.9647.3Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
197127951397.5107.053.5The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
197227951397.593.6846.8Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
197313971397.033.033.0Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
197413971397.033.333.3Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
197527941397.070.4235.2Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
197613971397.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
197713961396.049.4149.4The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
197813951395.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
197913941394.035.735.7Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
198013931393.026.5526.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
198113931393.047.0647.1Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
198227851392.579.2339.6Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
198313921392.044.3744.4Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
198427841392.077.6638.8Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
198513911391.092.6892.7Metazoan MicroRNAs. David P BartelCell201829570994No
198641711390.392.3730.8TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
198713901390.029.2629.3Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
198813901390.063.3263.3Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
198941691389.792.7930.9Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
199013891389.00.00.0Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
199113891389.037.3937.4Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
199227771388.570.9735.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
199327771388.562.131.1An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
199413881388.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
199527751387.50.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
199613871387.030.3830.4Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
199713871387.042.1542.1Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
199813861386.075.7475.7The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
199927711385.5169.6484.8Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
200027711385.50.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
200113851385.092.4492.4The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
200213851385.054.7554.8Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
200313851385.033.633.6The basic science of gene therapy. R C MulliganScience19938493530No
200413851385.033.7633.8Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
200527691384.572.0336.0A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
200613841384.041.1241.1The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
200741521384.088.8829.6Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
200813831383.040.1740.2Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
200913831383.031.9932.0Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
201013831383.026.4826.5NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
201113831383.034.2934.3The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
201227661383.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
201327641382.076.9238.5Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
201427641382.099.0649.5Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
201527631381.553.6626.8T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
201613811381.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
201727621381.084.3742.2From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
201813811381.034.0934.1Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
201913791379.038.3138.3Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
202013791379.047.3247.3Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
2021179161378.2490.5437.7Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
202213771377.031.6231.6The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
202327531376.5164.1582.1Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
202427521376.00.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
202527511375.582.6241.3Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
202627511375.568.4534.2Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
202727491374.50.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
202813741374.049.5349.5Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
202927471373.566.6433.3Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
203041201373.393.3731.1Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
203113731373.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
203213731373.045.5745.6Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
203327441372.088.5444.3Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
203413721372.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
203527441372.057.1228.6Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
203613721372.049.7849.8Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
203713721372.0125.73125.7Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
203827421371.00.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
203927401370.076.8338.4Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
204013701370.039.939.9The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
204127391369.570.6535.3Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
204227381369.094.0647.0Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
204341071369.0107.5135.8Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
204413691369.035.0535.0The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
204513681368.046.0846.1Interleukin-1. C A DinarelloRev Infect Dis19846369481No
204613671367.025.4825.5The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
204713671367.037.0137.0The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
204813671367.031.4931.5Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
204913671367.048.2748.3A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
205027311365.599.6349.8Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
205127311365.577.138.5Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
205213651365.066.0266.0Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
205313641364.030.5330.5Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
205427271363.586.243.1Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
205513631363.045.9345.9Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
205613631363.047.1947.2Multiple calcium channels and neuronal function. R J MillerScience19872432656No
205740871362.30.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
205827241362.00.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
205927221361.00.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
206013611361.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
206127201360.00.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
206227191359.577.6838.8Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
206327191359.5184.6292.3Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
206427181359.054.7227.4Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
206513591359.037.2437.2Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
206627171358.568.5934.3Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
206727161358.00.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
206813581358.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
206913581358.043.4743.5The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
207013571357.045.7845.8The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
207127141357.0121.9161.0ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
207227101355.069.2834.6Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
207313551355.040.4340.4Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
207413551355.030.6830.7Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
207527081354.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
207654151353.8286.6171.7Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
207713531353.038.8538.9Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
207827051352.584.6442.3The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
207940571352.30.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
208027031351.576.7738.4Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
208113501350.041.8441.8A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
208213501350.034.5934.6Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
208340481349.3117.6539.2I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
208426981349.077.7838.9Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
208513491349.035.2735.3Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
208626971348.50.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
208713481348.045.6545.6Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
208826961348.051.6925.8Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
208913481348.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
209013481348.041.2141.2Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
209113481348.030.5730.6Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
209213481348.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
209326941347.063.0731.5NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
209413471347.034.9134.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
209513461346.032.9933.0Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
209626921346.057.9429.0The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
209713451345.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
209813451345.044.6844.7SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
209926901345.00.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
210026891344.554.7327.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
210113441344.00.00.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
210213441344.040.540.5Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
210313431343.034.4834.5Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
210426861343.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
210513431343.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
210613431343.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
210726851342.580.5440.3What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
210826841342.053.4526.7Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
210913411341.041.4241.4Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
211026821341.070.4635.2Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
211126811340.50.00.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
211213401340.00.00.0Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
211313401340.088.088.0The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
211426801340.061.9531.0The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
211513401340.043.8643.9The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
211613401340.031.8231.8Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
211726791339.50.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
211813391339.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
211913391339.042.0942.1Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
212013391339.058.358.3Selenium and human health. Margaret P RaymanLancet201222381456No
212140161338.70.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
212240151338.3129.6543.2Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
212313381338.030.1330.1Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
212426741337.095.5347.8A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
212513371337.027.2227.2Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
212613371337.043.3943.4Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
212713361336.057.5657.6The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
212826721336.00.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
212913361336.036.5736.6The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
213013361336.029.5329.5A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
213126701335.0100.4150.2Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
213213351335.065.2565.2Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
213313351335.036.5636.6A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
213480071334.5281.746.9TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
213513341334.035.9836.0Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
213626681334.081.0940.5Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
213740011333.7124.7741.6Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
213813331333.030.6830.7Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
213913331333.043.1743.2Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
214026651332.50.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
214153291332.20.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
214213321332.028.0928.1Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
214313321332.079.979.9Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
214426631331.50.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
214513311331.042.0442.0The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
214613311331.047.7447.7Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
214726611330.555.427.7Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
214813301330.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
214926601330.0104.1952.1PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
215053191329.8125.0331.3Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
215139891329.7105.4635.2How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
215213291329.043.3143.3History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
215313291329.026.8826.9Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
215413291329.00.00.0Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
215526571328.50.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
215626571328.578.8139.4Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
215739851328.3142.2847.4Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
215826551327.583.4941.7Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
215926541327.064.4432.2The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
216013261326.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
216113261326.029.5229.5Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
216226521326.070.835.4Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
216339771325.7105.1935.1The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
216426511325.571.3835.7ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
216513251325.026.1226.1Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
216613251325.033.1333.1Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
216726501325.071.1935.6Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
216813251325.043.5243.5Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
216913251325.040.2740.3Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
217026491324.50.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
217126491324.575.2737.6The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
217213241324.035.5435.5Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
217313231323.042.6142.6Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
217413231323.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
217513231323.065.4465.4Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
217613231323.033.1833.2Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
217726461323.055.5927.8A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
217826461323.060.8430.4Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
217913221322.035.0235.0The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
218013221322.051.0851.1Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
218126441322.00.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
218226431321.561.2230.6The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
218313211321.042.0542.0The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
218413211321.031.7431.7Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
218513211321.025.8425.8Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
218613201320.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
218713201320.034.4734.5The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
218813201320.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
218926391319.560.730.4Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
219013191319.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
219113191319.038.6938.7The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
2192118641318.2374.7441.6The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
219313181318.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
219413181318.039.5939.6Strong localization of photons in certain disordered dielectric superlattices. JohnPhys Rev Lett198710034761Yes
219513181318.030.6430.6Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
219613181318.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
219713171317.034.8934.9Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
219839511317.0147.7249.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
219926321316.00.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
220013161316.041.2341.2Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
220126301315.092.2446.1The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
220213151315.033.8133.8N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
220313151315.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
220426281314.055.1127.6Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
220513141314.022.3422.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
220639411313.7745.13248.4An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
220726271313.581.9641.0Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
220813131313.052.6152.6Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
220913131313.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
221013131313.00.00.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
221139381312.7186.5562.2Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
221213121312.033.733.7Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
221313121312.031.6431.6Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
221413121312.029.9730.0Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
221513121312.029.3329.3The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
221613121312.024.0624.1The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
221713121312.024.2424.2Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
221813111311.033.3433.3A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
221913111311.025.1225.1The significance of responses of the genome to challenge. B McClintockScience198415739260No
222013111311.034.7434.7Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
222126221311.057.9629.0NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
222226211310.558.3629.2Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
222313101310.042.1142.1Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
222439301310.098.1532.7The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
222513101310.029.5329.5Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
222626201310.087.1543.6Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
222713091309.041.9441.9The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
222813081308.046.8846.9Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
222926151307.559.9330.0Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
223013071307.050.8850.9Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
223113071307.028.0428.0Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
223213071307.038.7438.7Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
223313071307.058.8558.9Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
223426131306.553.6326.8An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
223526121306.060.430.2Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
223613061306.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
223752231305.8156.4739.1Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
223852211305.2129.1832.3The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
223913051305.037.1137.1Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
224013041304.037.237.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
224113041304.048.7348.7Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
224213041304.031.7531.8Proinflammatory cytokines. C A DinarelloChest200010936147No
224313041304.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
224426071303.564.1432.1Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
224526071303.5148.8274.4The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
224613031303.044.9945.0Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
224713031303.046.7546.8Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
224813031303.042.1142.1Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
224913031303.029.6629.7Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
225013021302.034.2734.3Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
225126041302.058.6529.3Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
225226041302.077.5338.8The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
225326031301.560.0830.0A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
225413001300.028.3328.3The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
225513001300.032.4132.4The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
225612991299.023.3123.3Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
225712991299.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
225838971299.097.032.3Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
225912991299.046.8946.9Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
226038961298.785.5128.5Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
226138961298.795.8531.9Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
226212971297.036.3236.3The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
226338901296.780.927.0The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
226412961296.032.3732.4The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
226512961296.024.4824.5Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
226612961296.069.0669.1The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
226725911295.50.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
226825911295.553.6426.8Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
226977731295.5193.5432.3GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
227025901295.061.9731.0Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
227138851295.0106.5935.5TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
227225891294.585.1342.6The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
227325881294.00.00.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
227412941294.023.123.1Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
227525881294.092.546.2How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
227651751293.8126.7631.7Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
227725871293.577.0438.5miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
227812931293.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
227912931293.024.1524.1CD95's deadly mission in the immune system. P H KrammerNature200011048730No
228025851292.50.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
228112921292.031.3131.3Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
228212921292.034.1634.2Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
228312921292.028.0228.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
228490421291.7289.841.4AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
228525831291.598.5649.3Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
228612911291.035.6235.6Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
228725811290.50.00.0A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
228877421290.3207.9734.7Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228912901290.034.1234.1The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
229012901290.032.3532.4Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
229125791289.579.8639.9The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
229212891289.046.7546.8The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
229325781289.048.0824.0New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
229464411288.2195.1139.0Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
229512881288.042.1842.2Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
229625741287.00.00.0Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
229712871287.036.4736.5Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
229812861286.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
229925721286.043.6221.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
230012861286.054.7154.7MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
230138571285.7136.9845.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
230289991285.6323.8146.3GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
230325691284.50.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
230425691284.571.1635.6Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
230525691284.5137.9769.0mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
230625681284.00.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
230712841284.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
230812841284.033.8733.9Supported membranes: scientific and practical applications. E SackmannScience19968539599No
230912841284.022.8222.8Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
231025681284.055.3327.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
231112841284.022.7422.7The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
231225671283.556.6328.3LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
231312831283.030.7230.7Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
231476981283.0191.6331.9Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
231564121282.4244.1748.8Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
231612821282.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
231712821282.00.00.0Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
231825641282.067.633.8A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
231925631281.583.9842.0Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
232012811281.035.5535.5Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
232125621281.065.7732.9Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
232212801280.048.1848.2The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
232312801280.039.0139.0Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
232412801280.038.5438.5Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
232512791279.027.0527.1The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
232625581279.0112.256.1Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
2327140681278.9484.1444.0A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
232825571278.562.531.2Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
232912781278.051.9251.9An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
233012771277.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
233112771277.030.5930.6Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
233225541277.0100.9550.5Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
233312761276.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
233412761276.041.9141.9Somatostatin. S ReichlinN Engl J Med19836139753No
233512761276.037.337.3Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
233612751275.027.8227.8HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
233712751275.093.1993.2Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
233825491274.565.9133.0Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
233925491274.5114.7957.4A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
234038231274.383.0627.7A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
234125481274.00.00.0Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
234212741274.027.8327.8Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
234312741274.046.5446.5Substance P. B PernowPharmacol Rev19836196797No
234412741274.029.9730.0The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
234512741274.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
234638191273.0181.3960.5Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
234725451272.50.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
234812711271.033.0733.1Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
234912711271.034.5634.6Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
235025401270.083.5541.8Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
235112691269.029.1529.1Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
235212691269.023.5123.5c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
235312691269.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
235425371268.551.0325.5Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
235538041268.099.5733.2Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
235663381267.60.00.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
235725351267.565.232.6The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
235812671267.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
235912671267.045.0545.0Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
236012671267.052.6452.6Error in medicine. L L LeapeJAMA19947503827Yes
236112671267.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
236225341267.077.4338.7CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
236350671266.8215.9854.0Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
236425331266.50.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
236525331266.566.0133.0The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
236625331266.574.8437.4Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
236737991266.3154.2551.4Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
236812661266.033.8933.9The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
236912661266.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
237037961265.388.6429.5Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
237125301265.046.223.1Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
237212651265.034.7134.7Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
237312651265.048.2148.2Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
237425291264.555.9228.0Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
237525281264.049.6424.8Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
237663191263.8160.4532.1Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
2377101081263.5260.0132.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
237825271263.576.8938.4Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
237912631263.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
238012631263.029.629.6DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
238112631263.041.4441.4phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
238225241262.055.8627.9Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
238312611261.00.00.0Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
238425221261.066.3533.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
238512611261.026.3526.4Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
238612611261.038.0538.0Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
238712611261.057.3557.4Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
238812611261.023.2823.3SUMO: a history of modification. Ronald T HayMol Cell200515808504No
238912601260.025.8925.9Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
239012601260.048.0648.1The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
239125201260.0100.1850.1The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
239212591259.026.1726.2SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
239312591259.030.5730.6Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
239412591259.034.434.4The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
239512581258.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
239612581258.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
239712581258.028.3928.4Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
239888021257.4264.337.8Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
239937721257.3113.6837.9A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
240012571257.034.0134.0Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
240162851257.00.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
240212571257.067.1867.2Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
240325131256.590.2445.1Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
240425121256.067.5633.8Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
240512561256.031.7731.8Apoptosis. J J CohenImmunol Today19938466628No
240625111255.552.5826.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
240712551255.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
240812551255.043.1443.1Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
240912551255.041.2941.3An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
241012541254.028.1728.2Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
241112541254.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
241212541254.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
241312541254.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
241425081254.097.8448.9Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
241512531253.038.6438.6Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
241612531253.047.0147.0Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
241725061253.052.8926.4Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
241825061253.071.0935.5Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
241925061253.0102.6451.3The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
242012521252.030.6530.6Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
242112521252.020.8320.8Antigen receptor tail clue. M RethNature19892927501Yes
242212521252.025.7425.7Searching for genetic determinants in the new millennium. N J RischNature200010866211No
242312521252.028.3928.4Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
242412521252.024.6624.7microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
242512521252.038.238.2Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
242625031251.558.1329.1DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
242737541251.399.5233.2Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn Sci200010827444Yes
242812511251.056.2556.2Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
242912511251.035.6535.6Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
243087531250.4363.5851.9Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
243137511250.390.130.0Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
243212501250.029.3829.4Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
243325001250.058.929.4Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
243424991249.557.2128.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
243587451249.33457.06493.9Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
243612481248.040.2140.2The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
243774871247.8193.8832.3A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
243812471247.025.8525.9Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
243912471247.050.8350.8Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
244012471247.061.7461.7Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
244124931246.570.8835.4The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
244212461246.043.7443.7The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
244312461246.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
244412461246.00.00.0A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
244562261245.2236.2847.3The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
244624901245.00.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
244712451245.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
244824891244.577.338.6Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
244912441244.024.8424.8Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
245012431243.00.00.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
245124861243.00.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
245224841242.073.0136.5Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
245312421242.035.0335.0Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
245424841242.062.8931.4Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
245512411241.042.5542.5How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
245612411241.031.2731.3Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
245712411241.028.2328.2Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
245812411241.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
245912411241.035.1735.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
246012411241.028.8328.8Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
246162031240.6150.9530.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
246212401240.037.3437.3Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
246324801240.079.3539.7Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
246437191239.7129.0643.0Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
246524791239.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
2466136351239.5381.5834.7The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
246724791239.567.633.8Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
246812391239.024.8724.9STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
246912391239.029.0429.0Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
247012391239.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
247137161238.7132.9644.3A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
247299091238.6302.737.8The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
247312381238.031.8731.9The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
247412381238.060.260.2New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
247512381238.056.4956.5Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
247624761238.065.7532.9Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
247712381238.039.1539.1Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
247824751237.580.2140.1Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
247937121237.385.6428.5OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
248024731236.50.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
248137081236.0168.1156.0In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
248224721236.091.0445.5The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
248324721236.061.9631.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
2484111161235.1670.5674.5Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
248512351235.067.3167.3Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
248612351235.029.6329.6The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
248724691234.546.4523.2Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
248824681234.063.831.9Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
248912341234.026.0226.0The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
249012341234.033.7233.7Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
249137011233.795.0531.7Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
249249341233.5114.5328.6Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
249324671233.50.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
249449341233.5133.0833.3Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
249512331233.031.8631.9Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
249612321232.034.734.7Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
249724631231.562.4231.2The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
249824631231.568.3934.2Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
249924631231.563.2631.6Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
250012311231.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
250136931231.096.3232.1Atomic force microscope. Binnig, Quate, GerberPhys Rev Lett198610033323Yes
250224601230.00.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
250336861228.778.8226.3Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
250424561228.075.3437.7An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
250512281228.035.6435.6Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
250624561228.045.8222.9DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
250749101227.5143.9836.0Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
250824551227.554.6527.3The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
250924551227.564.3332.2Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
251012271227.037.6237.6Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
251124541227.068.434.2Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
251212271227.024.6324.6Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
251324541227.0110.0655.0Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
251449071226.8173.4543.4Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
251512261226.038.1838.2Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
251624521226.00.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
251724521226.069.3534.7What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
251812261226.032.3132.3Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
251912261226.038.6538.6Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
252012251225.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
252124501225.044.3122.2The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
252236751225.0112.8437.6Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
252324491224.561.5230.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
252412241224.061.461.4The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
252524481224.046.923.4Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
252612241224.029.1529.1Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
252712241224.028.1828.2Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
252812231223.022.3722.4Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
252924441222.00.00.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
253012221222.027.2427.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
253124441222.084.4342.2Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
253212221222.041.4341.4Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
253336651221.7111.5537.2Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
253436651221.792.1730.7Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
253524421221.086.3743.2How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
253612201220.030.9831.0Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
253724391219.568.3734.2Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
253824371218.547.6623.8CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
253960911218.2193.1238.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
254012181218.026.8926.9Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
254112181218.027.1427.1Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
254212181218.023.6823.7Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
254324341217.00.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
254424341217.062.3431.2Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
254512171217.039.1339.1Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
2546133851216.8331.1830.1New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
254724331216.539.8519.9A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
254824331216.562.5331.3Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
254936491216.392.9231.0LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
255012161216.026.1726.2Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
255112161216.029.7429.7Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
255272921215.3231.0738.5A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
255324301215.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
255412151215.032.5832.6Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
255512151215.036.1936.2Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
255612141214.031.2731.3Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
255712141214.055.2355.2Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
255836421214.087.9529.3Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
255912141214.033.9333.9Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
256024271213.549.3724.7Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
256136401213.373.9824.7The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
256248531213.2101.4225.4Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
256312131213.029.9129.9Huntington's disease. Francis O WalkerLancet200717240289No
256436371212.389.4929.8Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
256524221211.048.2524.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
256612111211.025.4725.5MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
256712111211.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
256812101210.029.3229.3Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
256912101210.032.2732.3Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
257012101210.033.7733.8The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
257112101210.069.9269.9Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
257212091209.022.0622.1The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
257336261208.777.6125.9Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
257412081208.038.2938.3Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
257512081208.026.0126.0Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
257612081208.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
257712081208.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
257824161208.00.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
257912081208.027.4827.5Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
258024161208.063.5331.8Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
258124161208.060.830.4Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
258212081208.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
258312081208.039.8339.8Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
258412071207.029.0429.0Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
258524141207.077.2338.6An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
258612071207.036.7236.7Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
258724131206.5125.3862.7A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
258824131206.546.4123.2The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
258912061206.029.7129.7Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
259012061206.028.5828.6Growth factors and cancer. S A AaronsonScience19911659742No
259112061206.021.3921.4Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
259236181206.063.1221.0A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
259312061206.032.832.8Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
259424101205.059.6429.8Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
259536131204.3103.1934.4Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
259612041204.035.5935.6The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
259712041204.046.9847.0Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
259812041204.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
259912041204.052.8852.9α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
260024071203.593.646.8Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
260124071203.575.4937.7Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
260212031203.027.1527.1Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
260360121202.4115.823.2Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260412011201.048.4348.4Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
260536031201.099.7233.2Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
260612011201.029.829.8Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
260712011201.037.3137.3Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
260812011201.027.9127.9The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
260936021200.7108.3236.1The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
261012001200.059.459.4ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
261112001200.056.2656.3A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
261223991199.557.3128.7Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
261311981198.038.1838.2Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
261411981198.026.8726.9S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
261511981198.0345.87345.9COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
261647901197.5110.627.6A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
261711971197.048.4648.5Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
261811971197.031.5431.5Drug delivery and targeting. R LangerNature19989579855No
261911971197.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
262023941197.050.8425.4ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
262135901196.786.628.9Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
262235891196.3103.4834.5trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
262311961196.027.2327.2Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
262423921196.060.8830.4Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
262511961196.054.0154.0Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
262635861195.380.2826.8Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
262711951195.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
262811951195.045.545.5Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
262911951195.028.3428.3Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
263011951195.036.2636.3Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
263111941194.043.4343.4Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
263211941194.054.5354.5Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
263311941194.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
263411941194.029.8229.8The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
263511941194.022.8622.9Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
263611941194.027.8527.9Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
263723861193.064.7732.4Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
263811931193.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
263911931193.041.7641.8Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
264011931193.026.0126.0The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
264111931193.031.5631.6Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
264211931193.032.0632.1Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
264311921192.00.00.0Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
264411921192.029.829.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
264523841192.064.3832.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
264611921192.025.2525.2Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
264711921192.031.5531.6Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
264811921192.045.5745.6The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
264923831191.556.7728.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
265011911191.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
265111911191.042.8742.9Plasma perspective on strong field multiphoton ionization. CorkumPhys Rev Lett199310054556Yes
265211911191.034.6634.7Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
265323821191.071.8335.9A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
265423821191.050.8425.4Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
265523821191.055.1927.6Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
265623801190.054.9727.5Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
265711891189.044.9244.9A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
265811891189.031.8631.9The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
265911891189.022.2322.2Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
266011881188.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
266111881188.028.7728.8Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
266235641188.0102.634.2Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
266311881188.032.7832.8The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
266423751187.50.00.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
266511871187.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
266611871187.035.3835.4The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
266735591186.3126.2242.1Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
266811861186.038.0938.1The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
266911861186.024.6924.7Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
267011861186.038.3238.3Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
267111861186.087.2987.3Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
267235571185.787.0629.0Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
267323711185.559.9530.0Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
267423711185.565.7232.9Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
267511851185.029.9730.0Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
267611851185.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
267723691184.564.2532.1A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
267871071184.5187.1531.2Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
267935531184.373.6224.5Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
268011841184.042.4942.5The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
268111831183.023.6923.7Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
268211831183.037.1237.1Endometriosis. Serdar E BulunN Engl J Med200919144942No
268311821182.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
268423641182.0274.41137.2Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
268511811181.041.0641.1The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
268611811181.033.2733.3Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
268723621181.00.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
2688165271180.5362.0625.9Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
268911801180.028.5728.6Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
269011801180.036.8336.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
269123601180.053.426.7The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
269211801180.034.8334.8Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
269323601180.048.0824.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
269411801180.026.2326.2Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
269511801180.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
269611791179.033.0333.0How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
269711791179.025.7925.8Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
269823571178.598.8949.4Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
269923561178.0153.376.7Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
270047121178.0102.1525.5Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
270111781178.029.9429.9Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
270223541177.046.3323.2Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
270311771177.029.5629.6Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
270435301176.786.4328.8Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
270511761176.036.2236.2The mysteries of lipoprotein(a). G UtermannScience19892530631No
270670561176.0136.0822.7Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
270711751175.00.00.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
270811751175.039.5439.5Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
270911751175.025.6325.6The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
271011751175.031.031.0Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
271111751175.041.8741.9Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
2712105671174.1355.5839.5A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
271311741174.026.4226.4Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
271411741174.026.7226.7Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
271511741174.025.2125.2Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
271611731173.049.0449.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
271711731173.026.1526.1The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
271823461173.095.5447.8Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
271923461173.063.3331.7Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
272023461173.0120.0560.0Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
272135181172.7102.6334.2Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
272211721172.019.5419.5Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
272311721172.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
272411721172.026.1526.1Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
272523441172.0113.8756.9The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
272611711171.00.00.0The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
272711711171.061.5661.6Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
272811711171.041.1341.1The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
272923411170.566.433.2Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
273023401170.00.00.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
273111701170.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
273235101170.087.6529.2Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
273323391169.563.0231.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
273411691169.021.421.4Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
273511691169.052.5752.6Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
273611691169.033.7433.7Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
273711691169.028.1328.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
273835051168.372.5624.2Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
273958381167.6191.9638.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
274011661166.036.9336.9Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
274111661166.026.0426.0The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
274211661166.031.6731.7Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
274323301165.070.2535.1Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
274411651165.079.1379.1The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
274511651165.00.00.0Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
274611651165.027.6527.6The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
274711651165.023.4123.4IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
274834931164.30.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
274911641164.032.1832.2Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
275034921164.00.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
275111641164.045.3745.4Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
275211641164.027.0827.1Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
275311641164.033.733.7The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
275411641164.033.1133.1Plant productivity and environment. J S BoyerScience198217808529Yes
275511631163.025.7625.8Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
275623261163.076.438.2Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
275734881162.7188.6162.9Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
275823251162.5145.9573.0A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
275923251162.551.0425.5Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
276034861162.00.00.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
276111611161.022.2922.3Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
276211611161.030.6630.7Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
276311611161.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
276411611161.026.3526.4Human natural killer cells. Michael A CaligiuriBlood200818650461No
276592841160.5445.6655.7The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
276611601160.059.959.9Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
276711601160.073.5973.6Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
276811601160.030.0130.0Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
276911601160.029.7829.8Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
277023201160.062.7931.4Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
277123181159.00.00.0Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
277211591159.032.4132.4Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
277311591159.030.9430.9Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
277469521158.7235.5139.3Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
277523171158.551.8425.9Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
277611581158.040.840.8Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
277711581158.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
277811581158.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
277911581158.027.2827.3Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
278023151157.50.00.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
278123151157.5113.256.63D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
278211571157.027.0827.1Brain tumors. L M DeAngelisN Engl J Med200111150363No
278323131156.5122.2561.1Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
2784127131155.7362.2732.9The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
278523101155.00.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
278611551155.026.026.0Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
278711551155.019.8119.8Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
278811551155.026.0526.1Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
278923091154.576.738.4Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
279023091154.593.7246.9The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
279134621154.00.00.0High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
279211541154.031.9932.0Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
279311531153.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
279411531153.020.720.7Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
279523051152.50.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
279611521152.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
279723011150.548.824.4Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
279834501150.072.8424.3Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
279923001150.042.1721.1Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
280011501150.027.6227.6Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
280111501150.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
280222991149.564.532.2Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
280322991149.5136.9768.5MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
280411491149.026.3726.4Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
280522981149.063.2431.6EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
280611491149.053.1853.2Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
280722971148.50.00.0Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
280822971148.50.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
280945941148.5135.2933.8Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
281022961148.062.9531.5Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
281134431147.769.8823.3Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
281211471147.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
281322941147.049.6524.8Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
281411471147.031.031.0Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
281534401146.793.7631.3Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
281622931146.578.4739.2LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
281711461146.00.00.0Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
281811461146.034.5734.6Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
281911461146.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
282011461146.034.4634.5The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
282111461146.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
282222921146.052.4526.2Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
282322921146.065.5232.8The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
282411461146.046.1646.2The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
282522901145.00.00.0Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
282611451145.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
282745791144.8112.8628.2Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
282822891144.564.532.2Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
282922891144.554.8327.4Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
283022881144.046.6223.3A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
283111441144.046.2846.3Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
283211441144.032.3432.3DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
283334321144.087.2829.1Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
283411441144.028.2628.3Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
283545731143.2109.1427.3Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
283611431143.041.1141.1The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
283734281142.70.00.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
283834281142.796.9732.3Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
283922851142.548.8324.4Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
284022841142.065.0232.5Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
284122841142.045.2122.6Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
284222841142.00.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
284311421142.032.1932.2The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
284411421142.029.829.8Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
284511421142.034.5134.5High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
284611421142.039.5339.5Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
284722831141.568.6634.3Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
284822831141.545.5722.8Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
284911411141.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
285022821141.071.1535.6Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
285111411141.023.8323.8Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
285234221140.7109.4936.5MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
285311401140.047.747.7A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
285411401140.032.8432.8The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
285511401140.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
285622791139.573.3936.7Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
285711391139.024.4224.4Stem cells in the central nervous system. R McKayScience19979082987No
285811391139.034.8334.8Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
285911391139.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
286011391139.031.0231.0Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
286122771138.553.8626.9Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
286211381138.00.00.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
286311381138.033.2233.2A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
286411381138.022.2522.2Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
286511381138.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
286634131137.779.0326.3Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
286722751137.551.0925.5Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
286822751137.565.3232.7Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
286934121137.388.3829.5Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
287034121137.3110.6336.9Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
287111371137.036.5536.5Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
287211371137.032.4932.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
287311371137.036.6136.6Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
287411371137.069.7469.7Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
287534091136.30.00.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
287611361136.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
287711361136.024.8224.8An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
287811361136.028.0628.1Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
287911361136.037.0537.0Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
288011361136.039.8739.9Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
288122711135.551.5925.8The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
288211351135.00.00.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
288311351135.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
288411351135.027.8127.8Optical microcavities. Kerry J VahalaNature200312917698Yes
288511351135.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
288622701135.098.3249.2Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
288722691134.569.9635.0Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
288845361134.0111.7427.9Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
288911341134.023.4323.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
289011341134.027.9427.9Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
289111341134.033.7433.7Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
289222681134.055.2627.6Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
289311331133.041.3241.3Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
289422661133.066.6833.3Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
289511331133.026.7526.8Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
289611331133.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
289711331133.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
289833991133.078.026.0Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
289911321132.00.00.0A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
290022641132.056.3728.2C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
290111321132.029.5229.5Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
290222631131.562.7831.4A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
290322631131.585.3842.7Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
290411311131.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
290511311131.032.532.5Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
290611311131.028.4228.4Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
290711301130.033.8433.8Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
290811301130.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
290922601130.061.4730.7Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
291079101130.0161.9423.1Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
291111301130.030.2530.2Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
291211291129.031.0831.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
291311291129.00.00.0Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
291411291129.026.926.9Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
291522581129.00.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
291611291129.038.7738.8Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
291711291129.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
291845141128.5106.9426.7Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
291922571128.5137.3168.7Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
292011281128.042.0142.0The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
292111281128.033.8933.9Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
292222561128.098.5149.3Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
292311281128.0105.19105.2The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
292422561128.066.8433.4Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
292511281128.022.0922.1Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
292611271127.031.5431.5Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
292722541127.00.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
292811271127.041.041.0AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
292922531126.551.2625.6Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
293022531126.544.1722.1NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
293122531126.560.330.1Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
293211261126.028.7328.7Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
293311261126.043.3643.4On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
293411261126.026.5726.6Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
293522521126.041.6520.8Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
293611261126.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
293711261126.047.547.5What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
293867551125.8205.9934.3Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
293922511125.548.2824.1NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
294011251125.022.2622.3Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
294111251125.039.7639.8Density matrix formulation for quantum renormalization groups. WhitePhys Rev Lett199210046608Yes
294211251125.033.7433.7Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
294311251125.038.1438.1How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
294411251125.030.6830.7Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
294544991124.8102.7425.7Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
294644971124.2126.8931.7Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
294711241124.030.3730.4The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
294822471123.566.7333.4Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
294922461123.084.5442.3Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
295011231123.039.139.1The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
295167371122.8233.138.9The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
295222451122.547.9524.0The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
295311221122.00.00.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
295411221122.023.5323.5Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
295522441122.066.7933.4Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
295611221122.035.4435.4Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
295744851121.2104.6826.2SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
295822411120.561.9131.0Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
295956011120.2192.4238.5Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
296022401120.069.6734.8A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
296111201120.033.0733.1Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
296211201120.029.8729.9The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
296344781119.5130.7632.7Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
296422391119.578.8539.4Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
296511191119.00.00.0Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
296611191119.031.2531.2Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
296711191119.037.2437.2Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
296822371118.544.3522.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
296933531117.779.6926.6Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
297022351117.543.3121.7Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
297111171117.042.0942.1Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
297211171117.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
297311171117.039.3539.4Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
297422341117.058.6129.3Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
297511161116.027.3827.4Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
297633481116.0158.0852.7The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
297744611115.20.00.0Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
297822301115.046.5123.3Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
297911151115.042.6842.7Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
298011151115.023.6623.7ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
298111151115.032.7432.7Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
298211151115.031.2131.2Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
298311151115.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
298444581114.5153.9238.5Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
298511141114.00.00.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
298611141114.023.6823.7Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
2987