Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	224570	224570.0	4918.17	4918.2	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	173039	173039.0	7117.46	7117.5	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	285846	71461.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	122965	61482.5	3049.8	1524.9	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	45262	45262.0	1392.64	1392.6	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	36877	36877.0	1188.2	1188.2	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	64397	32198.5	1932.53	966.3	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30232	30232.0	822.98	823.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	28001	28001.0	858.84	858.8	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	27822	27822.0	612.43	612.4	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	27004	27004.0	637.58	637.6	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
12	26032	26032.0	674.73	674.7	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
13	24786	24786.0	567.85	567.9	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
14	24419	24419.0	759.87	759.9	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
15	66383	22127.7	2489.03	829.7	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
16	65976	21992.0	1651.53	550.5	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
17	42783	21391.5	1329.35	664.7	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
18	20279	20279.0	204.98	205.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
19	40196	20098.0	1241.7	620.9	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
20	20090	20090.0	688.88	688.9	Density-functional exchange-energy approximation with correct asymptotic behavior.	A D Becke	Phys Rev A Gen Phys	1988	9900728	Yes
21	19600	19600.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
22	18301	18301.0	510.56	510.6	Projector augmented-wave method.	P E Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
23	36421	18210.5	1720.89	860.4	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	35947	17973.5	1501.69	750.8	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
25	53491	17830.3	1985.42	661.8	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
26	17262	17262.0	634.57	634.6	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
27	17099	17099.0	724.52	724.5	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
28	16960	16960.0	425.6	425.6	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
29	16756	16756.0	687.73	687.7	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
30	16396	16396.0	673.87	673.9	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
31	32418	16209.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
32	16203	16203.0	449.18	449.2	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
33	15924	15924.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
34	31109	15554.5	986.66	493.3	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
35	46219	15406.3	1370.76	456.9	Generalized Gradient Approximation Made Simple.	J P Perdew, K Burke, M Ernzerhof	Phys Rev Lett	1996	10062328	Yes
36	15397	15397.0	386.24	386.2	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
37	30259	15129.5	1210.73	605.4	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
38	45386	15128.7	1296.34	432.1	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
39	45258	15086.0	1676.08	558.7	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
40	30171	15085.5	762.75	381.4	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
41	29763	14881.5	1115.55	557.8	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
42	14440	14440.0	562.37	562.4	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
43	41878	13959.3	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
44	13312	13312.0	681.23	681.2	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
45	63380	12676.0	1817.26	363.5	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
46	12621	12621.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
47	25096	12548.0	517.71	258.9	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
48	12473	12473.0	399.82	399.8	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
49	24868	12434.0	1018.82	509.4	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
50	24810	12405.0	680.85	340.4	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	G Kresse, J Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
51	12326	12326.0	314.74	314.7	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
52	36036	12012.0	1271.46	423.8	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	C Lee, W Yang, R G Parr	Phys Rev B Condens Matter	1988	9944570	Yes
53	11995	11995.0	136.92	136.9	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
54	23902	11951.0	521.28	260.6	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
55	11947	11947.0	361.46	361.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
56	11931	11931.0	554.04	554.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
57	23760	11880.0	642.21	321.1	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
58	11759	11759.0	386.61	386.6	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
59	33751	11250.3	1315.82	438.6	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
60	10974	10974.0	381.3	381.3	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
61	10966	10966.0	418.31	418.3	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
62	10961	10961.0	438.99	439.0	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
63	21562	10781.0	557.92	279.0	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
64	21342	10671.0	816.19	408.1	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
65	10539	10539.0	365.91	365.9	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
66	31583	10527.7	821.29	273.8	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
67	21033	10516.5	460.8	230.4	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
68	31277	10425.7	1052.69	350.9	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
69	20782	10391.0	890.65	445.3	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
70	41199	10299.8	1176.65	294.2	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
71	41181	10295.2	1588.64	397.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
72	10291	10291.0	201.98	202.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
73	20525	10262.5	441.53	220.8	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
74	9952	9952.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
75	19796	9898.0	372.65	186.3	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
76	9663	9663.0	271.88	271.9	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
77	9624	9624.0	434.85	434.9	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
78	9568	9568.0	410.87	410.9	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
79	9555	9555.0	253.48	253.5	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
80	9547	9547.0	198.5	198.5	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
81	9491	9491.0	318.72	318.7	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
82	18980	9490.0	490.97	245.5	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
83	9380	9380.0	248.18	248.2	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
84	9323	9323.0	268.73	268.7	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
85	9321	9321.0	272.34	272.3	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
86	9297	9297.0	240.61	240.6	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
87	9256	9256.0	263.23	263.2	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
88	36707	9176.8	1345.5	336.4	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
89	9170	9170.0	259.38	259.4	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
90	18231	9115.5	381.78	190.9	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
91	9035	9035.0	233.17	233.2	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
92	26627	8875.7	681.57	227.2	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
93	17594	8797.0	462.44	231.2	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
94	35169	8792.2	1136.63	284.2	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
95	8781	8781.0	177.39	177.4	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
96	8757	8757.0	211.45	211.4	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
97	52255	8709.2	3438.59	573.1	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
98	8704	8704.0	226.26	226.3	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
99	8676	8676.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
100	17281	8640.5	379.17	189.6	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
101	8536	8536.0	180.91	180.9	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
102	8455	8455.0	221.27	221.3	Canonical dynamics: Equilibrium phase-space distributions.	W G Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
103	8344	8344.0	353.26	353.3	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
104	24937	8312.3	662.51	220.8	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
105	8248	8248.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
106	8248	8248.0	215.71	215.7	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
107	24677	8225.7	1372.49	457.5	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
108	8224	8224.0	410.11	410.1	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
109	8183	8183.0	241.44	241.4	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
110	8097	8097.0	198.52	198.5	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
111	23834	7944.7	700.82	233.6	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
112	7913	7913.0	365.6	365.6	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
113	7862	7862.0	217.36	217.4	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
114	15628	7814.0	381.3	190.7	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
115	7793	7793.0	225.86	225.9	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
116	7786	7786.0	216.07	216.1	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
117	7780	7780.0	210.29	210.3	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
118	15463	7731.5	346.88	173.4	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
119	7698	7698.0	151.21	151.2	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
120	7632	7632.0	214.54	214.5	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
121	7631	7631.0	222.12	222.1	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
122	7584	7584.0	187.2	187.2	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	7536	7536.0	160.91	160.9	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
124	15031	7515.5	505.14	252.6	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
125	22485	7495.0	879.35	293.1	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
126	14932	7466.0	355.57	177.8	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
127	22301	7433.7	674.64	224.9	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
128	7364	7364.0	124.24	124.2	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
129	14728	7364.0	453.29	226.6	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
130	51547	7363.9	1327.76	189.7	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
131	7354	7354.0	243.01	243.0	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	J P Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
132	7256	7256.0	229.66	229.7	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
133	7185	7185.0	216.85	216.8	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
134	28354	7088.5	927.09	231.8	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
135	7054	7054.0	192.17	192.2	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
136	48793	6970.4	7232.28	1033.2	Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.	Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray	CA Cancer J Clin	2021	33538338	Yes
137	6970	6970.0	245.14	245.1	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
138	13739	6869.5	352.1	176.1	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
139	6837	6837.0	183.54	183.5	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
140	6704	6704.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
141	13203	6601.5	714.81	357.4	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
142	6596	6596.0	173.78	173.8	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
143	13163	6581.5	309.7	154.8	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
144	13144	6572.0	308.14	154.1	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
145	6566	6566.0	214.32	214.3	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
146	19663	6554.3	551.12	183.7	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
147	13092	6546.0	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
148	6544	6544.0	172.27	172.3	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
149	6521	6521.0	129.37	129.4	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
150	6511	6511.0	169.07	169.1	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
151	12963	6481.5	358.79	179.4	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
152	6396	6396.0	128.93	128.9	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
153	6362	6362.0	150.07	150.1	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
154	6359	6359.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
155	6352	6352.0	112.44	112.4	A Self-Rating Depression Scale.	W W Zung	Arch Gen Psychiatry	1965	14221692	Yes
156	6347	6347.0	135.17	135.2	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
157	12590	6295.0	524.48	262.2	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
158	12578	6289.0	430.87	215.4	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
159	6245	6245.0	215.33	215.3	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
160	6226	6226.0	135.92	135.9	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
161	6203	6203.0	146.11	146.1	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
162	12395	6197.5	345.13	172.6	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
163	6184	6184.0	144.55	144.6	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
164	6160	6160.0	141.49	141.5	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
165	12246	6123.0	434.36	217.2	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
166	18322	6107.3	907.93	302.6	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
167	6099	6099.0	114.18	114.2	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
168	6085	6085.0	149.01	149.0	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
169	6030	6030.0	152.48	152.5	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
170	6026	6026.0	151.93	151.9	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
171	23967	5991.8	771.37	192.8	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
172	5988	5988.0	144.59	144.6	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
173	11913	5956.5	289.39	144.7	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
174	11843	5921.5	805.27	402.6	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
175	5916	5916.0	136.69	136.7	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
176	17454	5818.0	612.94	204.3	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
177	11632	5816.0	267.43	133.7	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
178	5799	5799.0	178.45	178.4	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
179	11582	5791.0	316.21	158.1	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
180	11562	5781.0	252.29	126.1	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
181	5763	5763.0	75.46	75.5	The Environment And Disease: Association Or Causation?	A B Hill	Proc R Soc Med	1965	14283879	Yes
182	5741	5741.0	255.35	255.3	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
183	5701	5701.0	142.96	143.0	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
184	11394	5697.0	470.31	235.2	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
185	11376	5688.0	251.0	125.5	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
186	11349	5674.5	299.6	149.8	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
187	5665	5665.0	158.26	158.3	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
188	5631	5631.0	124.76	124.8	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
189	11248	5624.0	0.0	0.0	A series of normal stages in the development of the chick embryo.	V Hamburger, H L Hamilton	J Morphol	1951	24539719	Yes
190	5618	5618.0	177.98	178.0	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
191	5583	5583.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D Harman	J Gerontol	1956	13332224	Yes
192	5563	5563.0	133.23	133.2	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
193	5556	5556.0	106.74	106.7	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
194	5545	5545.0	220.6	220.6	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
195	5543	5543.0	92.67	92.7	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
196	5514	5514.0	119.69	119.7	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
197	5505	5505.0	181.05	181.1	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
198	10994	5497.0	255.79	127.9	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
199	5494	5494.0	92.88	92.9	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
200	16425	5475.0	493.61	164.5	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
201	10925	5462.5	287.33	143.7	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
202	10866	5433.0	230.45	115.2	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
203	10861	5430.5	962.87	481.4	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
204	5418	5418.0	259.44	259.4	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
205	10797	5398.5	276.16	138.1	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
206	10782	5391.0	357.57	178.8	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
207	10704	5352.0	299.8	149.9	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
208	5345	5345.0	158.07	158.1	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
209	5341	5341.0	163.48	163.5	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
210	5335	5335.0	137.26	137.3	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
211	5312	5312.0	139.99	140.0	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
212	5297	5297.0	134.85	134.8	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
213	26438	5287.6	714.2	142.8	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
214	5277	5277.0	127.68	127.7	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
215	5275	5275.0	102.73	102.7	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
216	15806	5268.7	592.37	197.5	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
217	5262	5262.0	151.99	152.0	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
218	10523	5261.5	490.38	245.2	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
219	10510	5255.0	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L Hodgkin, A F Huxley	J Physiol	1952	12991237	Yes
220	5231	5231.0	142.71	142.7	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
221	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J Scheidegger	Int Arch Allergy Appl Immunol	1955	13262900	Yes
222	5216	5216.0	118.08	118.1	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
223	5210	5210.0	198.14	198.1	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
224	5208	5208.0	189.17	189.2	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
225	5192	5192.0	53.38	53.4	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P Lauren	Acta Pathol Microbiol Scand	1965	14320675	Yes
226	5191	5191.0	66.14	66.1	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
227	10370	5185.0	226.84	113.4	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
228	15522	5174.0	382.52	127.5	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
229	10297	5148.5	365.38	182.7	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
230	5120	5120.0	124.58	124.6	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
231	5098	5098.0	101.69	101.7	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
232	10195	5097.5	270.9	135.4	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
233	10180	5090.0	241.91	121.0	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
234	5080	5080.0	186.76	186.8	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
235	10138	5069.0	220.24	110.1	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
236	5066	5066.0	102.02	102.0	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
237	5029	5029.0	196.67	196.7	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
238	20071	5017.8	512.79	128.2	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
239	29960	4993.3	1046.91	174.5	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
240	14934	4978.0	538.75	179.6	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
241	24820	4964.0	1079.21	215.8	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
242	14865	4955.0	1042.78	347.6	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
243	4951	4951.0	130.14	130.1	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
244	4951	4951.0	230.19	230.2	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
245	9849	4924.5	234.75	117.4	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
246	4910	4910.0	140.44	140.4	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
247	4898	4898.0	115.21	115.2	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
248	9795	4897.5	351.09	175.5	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
249	14606	4868.7	392.87	131.0	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
250	4841	4841.0	97.66	97.7	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
251	4827	4827.0	90.39	90.4	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
252	14456	4818.7	1291.32	430.4	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
253	4818	4818.0	146.64	146.6	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
254	14449	4816.3	357.37	119.1	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
255	24069	4813.8	408.84	81.8	An inventory for measuring depression.	A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh	Arch Gen Psychiatry	1961	13688369	Yes
256	9597	4798.5	259.34	129.7	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
257	4793	4793.0	176.02	176.0	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
258	14374	4791.3	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G Gornall, C J Bardawill, M M David	J Biol Chem	1949	18110453	Yes
259	4784	4784.0	142.47	142.5	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M Rodbell	J Biol Chem	1964	14169133	Yes
260	4772	4772.0	107.05	107.0	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
261	4760	4760.0	104.65	104.7	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
262	9500	4750.0	158.39	79.2	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
263	9465	4732.5	209.98	105.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
264	9457	4728.5	173.12	86.6	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
265	9423	4711.5	156.41	78.2	Functional Evaluation: The Barthel Index.	F I Mahoney, D W Barthel	Md State Med J	1965	14258950	Yes
266	9415	4707.5	237.04	118.5	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
267	9409	4704.5	320.03	160.0	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
268	14104	4701.3	558.31	186.1	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
269	4698	4698.0	156.98	157.0	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
270	4681	4681.0	103.16	103.2	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
271	4680	4680.0	210.74	210.7	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
272	14037	4679.0	485.25	161.8	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
273	14033	4677.7	306.52	102.2	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
274	4673	4673.0	130.02	130.0	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
275	4669	4669.0	76.31	76.3	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V Born	Nature	1962	13871375	Yes
276	4643	4643.0	118.52	118.5	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
277	18549	4637.2	533.24	133.3	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
278	4636	4636.0	102.91	102.9	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
279	9270	4635.0	253.19	126.6	Ab initio molecular dynamics for liquid metals.	G Kresse, J Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
280	18506	4626.5	298.51	74.6	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L Ellman, K D Courtney, V Andres, R M Feather-Stone	Biochem Pharmacol	1961	13726518	Yes
281	9246	4623.0	336.93	168.5	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
282	4622	4622.0	40.42	40.4	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L Hayflick	Exp Cell Res	1965	14315085	Yes
283	4576	4576.0	142.5	142.5	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
284	13712	4570.7	601.68	200.6	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
285	9130	4565.0	202.84	101.4	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
286	9112	4556.0	139.48	69.7	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
287	4549	4549.0	93.66	93.7	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
288	9098	4549.0	374.87	187.4	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
289	4520	4520.0	97.02	97.0	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
290	4497	4497.0	117.91	117.9	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
291	8960	4480.0	214.18	107.1	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
292	8941	4470.5	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T Litchfield, F Wilcoxon	J Pharmacol Exp Ther	1949	18152921	Yes
293	4470	4470.0	90.21	90.2	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
294	4466	4466.0	102.57	102.6	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
295	26732	4455.3	923.26	153.9	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
296	4454	4454.0	105.87	105.9	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
297	4437	4437.0	107.73	107.7	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
298	8868	4434.0	237.41	118.7	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
299	13236	4412.0	476.23	158.7	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
300	13230	4410.0	422.58	140.9	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
301	4398	4398.0	90.33	90.3	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
302	8780	4390.0	220.1	110.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
303	8773	4386.5	202.91	101.5	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
304	8767	4383.5	161.08	80.5	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
305	4378	4378.0	83.58	83.6	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
306	4352	4352.0	221.49	221.5	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
307	26055	4342.5	954.22	159.0	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
308	4341	4341.0	81.39	81.4	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
309	13013	4337.7	634.08	211.4	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
310	4336	4336.0	111.92	111.9	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
311	4335	4335.0	158.06	158.1	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
312	12952	4317.3	560.52	186.8	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
313	4316	4316.0	101.5	101.5	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
314	8631	4315.5	320.8	160.4	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
315	8623	4311.5	248.97	124.5	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
316	4306	4306.0	128.81	128.8	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
317	17191	4297.8	515.25	128.8	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
318	8593	4296.5	355.88	177.9	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
319	8587	4293.5	124.47	62.2	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M Hunter, F C Greenwood	Nature	1962	14450081	Yes
320	12851	4283.7	758.01	252.7	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
321	12825	4275.0	420.8	140.3	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
322	4272	4272.0	113.28	113.3	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
323	17077	4269.2	537.67	134.4	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
324	4263	4263.0	92.45	92.5	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
325	4259	4259.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B De B Weir	J Physiol	1949	15394301	Yes
326	8514	4257.0	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H Kellgren, J S Lawrence	Ann Rheum Dis	1957	13498604	Yes
327	4250	4250.0	90.43	90.4	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
328	4244	4244.0	159.04	159.0	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
329	4241	4241.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M Abercrombie	Anat Rec	1946	21015608	Yes
330	4236	4236.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T Nash	Biochem J	1953	13105648	Yes
331	4232	4232.0	87.52	87.5	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
332	4229	4229.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
333	4222	4222.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H Eagle	Science	1959	13675766	Yes
334	4218	4218.0	109.75	109.8	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
335	4216	4216.0	93.91	93.9	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
336	25278	4213.0	824.85	137.5	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
337	4209	4209.0	91.46	91.5	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
338	4199	4199.0	75.76	75.8	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
339	4198	4198.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P Dole	J Clin Invest	1956	13286333	Yes
340	4181	4181.0	87.16	87.2	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
341	8355	4177.5	224.01	112.0	Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii.	Daniel E Voth, Robert A Heinzen	Cell Microbiol	2007	17381428	No
342	29210	4172.9	643.37	91.9	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
343	12495	4165.0	463.75	154.6	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
344	4162	4162.0	92.29	92.3	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
345	4162	4162.0	108.69	108.7	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
346	8322	4161.0	306.93	153.5	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
347	4151	4151.0	50.44	50.4	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
348	16594	4148.5	621.7	155.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
349	4140	4140.0	173.18	173.2	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
350	8280	4140.0	177.8	88.9	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
351	4134	4134.0	0.0	0.0	The determination of enzyme inhibitor constants.	M Dixon	Biochem J	1953	13093635	Yes
352	8262	4131.0	213.46	106.7	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
353	4106	4106.0	194.66	194.7	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
354	8208	4104.0	262.33	131.2	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
355	4099	4099.0	127.29	127.3	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
356	4092	4092.0	128.48	128.5	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
357	4092	4092.0	150.49	150.5	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
358	4065	4065.0	84.38	84.4	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
359	4060	4060.0	173.31	173.3	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
360	4048	4048.0	101.75	101.8	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
361	8089	4044.5	206.93	103.5	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
362	12128	4042.7	627.13	209.0	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
363	36366	4040.7	921.14	102.3	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
364	4040	4040.0	127.26	127.3	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
365	4026	4026.0	109.01	109.0	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
366	4021	4021.0	136.51	136.5	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
367	4016	4016.0	78.75	78.8	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
368	15998	3999.5	582.26	145.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
369	3998	3998.0	103.55	103.5	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
370	11972	3990.7	453.36	151.1	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
371	3986	3986.0	70.15	70.2	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
372	3984	3984.0	106.86	106.9	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
373	7966	3983.0	221.1	110.5	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
374	3971	3971.0	128.17	128.2	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
375	3967	3967.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L Watson	J Biophys Biochem Cytol	1958	13563554	Yes
376	3964	3964.0	115.56	115.6	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	D Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
377	3960	3960.0	97.22	97.2	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
378	7905	3952.5	149.25	74.6	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
379	11830	3943.3	302.32	100.8	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
380	3943	3943.0	99.82	99.8	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
381	7865	3932.5	200.06	100.0	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
382	7846	3923.0	219.14	109.6	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
383	3916	3916.0	103.52	103.5	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
384	3913	3913.0	104.12	104.1	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
385	3913	3913.0	155.55	155.6	Disc Electrophoresis. I. Background And Theory.	L Ornstein	Ann N Y Acad Sci	1964	14240533	Yes
386	3903	3903.0	120.51	120.5	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
387	3900	3900.0	84.87	84.9	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
388	11688	3896.0	316.02	105.3	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
389	3894	3894.0	83.95	84.0	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
390	3883	3883.0	80.24	80.2	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
391	3878	3878.0	119.31	119.3	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
392	3872	3872.0	128.65	128.7	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
393	7737	3868.5	146.12	73.1	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
394	7721	3860.5	190.33	95.2	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
395	3856	3856.0	130.57	130.6	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
396	3837	3837.0	101.88	101.9	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
397	3837	3837.0	108.58	108.6	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
398	15346	3836.5	358.45	89.6	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
399	7649	3824.5	255.33	127.7	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
400	3824	3824.0	97.14	97.1	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
401	3823	3823.0	91.16	91.2	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
402	3823	3823.0	97.66	97.7	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
403	19089	3817.8	740.93	148.2	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
404	3816	3816.0	95.39	95.4	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
405	3812	3812.0	93.95	94.0	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
406	3811	3811.0	103.22	103.2	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
407	3801	3801.0	84.43	84.4	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
408	3793	3793.0	73.95	74.0	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
409	3792	3792.0	80.47	80.5	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
410	3791	3791.0	80.66	80.7	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
411	3769	3769.0	109.03	109.0	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
412	7530	3765.0	181.62	90.8	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
413	3765	3765.0	77.45	77.5	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
414	7520	3760.0	209.45	104.7	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
415	3759	3759.0	118.65	118.7	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
416	3757	3757.0	158.33	158.3	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
417	3753	3753.0	87.22	87.2	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
418	3749	3749.0	107.1	107.1	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
419	7496	3748.0	166.05	83.0	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
420	7493	3746.5	189.28	94.6	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
421	3745	3745.0	126.22	126.2	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
422	3745	3745.0	89.2	89.2	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
423	3741	3741.0	99.63	99.6	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
424	11221	3740.3	215.07	71.7	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
425	7480	3740.0	300.33	150.2	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
426	3735	3735.0	170.54	170.5	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
427	14880	3720.0	384.06	96.0	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
428	3703	3703.0	61.47	61.5	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
429	7404	3702.0	177.9	89.0	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
430	3696	3696.0	107.58	107.6	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
431	3690	3690.0	106.31	106.3	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
432	7369	3684.5	253.4	126.7	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
433	3679	3679.0	106.04	106.0	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
434	3675	3675.0	66.18	66.2	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
435	7344	3672.0	161.71	80.9	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
436	7333	3666.5	183.74	91.9	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
437	3665	3665.0	102.89	102.9	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
438	14659	3664.8	468.76	117.2	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
439	3663	3663.0	88.74	88.7	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
440	3660	3660.0	103.17	103.2	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
441	3655	3655.0	85.47	85.5	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
442	3638	3638.0	94.74	94.7	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
443	3636	3636.0	100.63	100.6	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
444	3618	3618.0	91.86	91.9	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
445	21708	3618.0	985.55	164.3	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
446	7235	3617.5	183.2	91.6	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
447	3617	3617.0	112.62	112.6	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
448	3602	3602.0	108.06	108.1	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
449	3593	3593.0	84.58	84.6	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
450	10702	3567.3	259.01	86.3	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
451	3564	3564.0	74.6	74.6	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
452	3547	3547.0	70.92	70.9	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
453	3536	3536.0	96.88	96.9	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
454	3534	3534.0	108.46	108.5	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
455	3528	3528.0	163.9	163.9	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
456	3522	3522.0	80.04	80.0	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
457	7043	3521.5	360.27	180.1	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
458	3521	3521.0	66.88	66.9	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
459	3515	3515.0	80.18	80.2	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
460	7029	3514.5	126.86	63.4	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
461	7026	3513.0	146.13	73.1	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
462	3511	3511.0	104.91	104.9	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
463	3511	3511.0	84.01	84.0	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
464	3510	3510.0	54.2	54.2	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
465	3506	3506.0	91.05	91.0	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
466	3505	3505.0	112.72	112.7	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
467	17522	3504.4	494.99	99.0	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
468	3499	3499.0	55.02	55.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
469	6984	3492.0	83.08	41.5	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H Hubel, T N Wiesel	J Physiol	1962	14449617	Yes
470	3489	3489.0	58.93	58.9	Statistical estimations in enzyme kinetics.	G N Wilkinson	Biochem J	1961	13785321	Yes
471	3486	3486.0	107.92	107.9	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
472	3483	3483.0	86.12	86.1	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
473	6964	3482.0	175.61	87.8	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
474	3477	3477.0	51.9	51.9	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F Woessner	Arch Biochem Biophys	1961	13786180	Yes
475	10427	3475.7	257.25	85.8	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
476	3475	3475.0	84.86	84.9	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
477	3472	3472.0	86.51	86.5	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
478	10415	3471.7	393.62	131.2	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
479	3470	3470.0	80.83	80.8	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
480	3463	3463.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A Miller	Psychol Rev	1956	13310704	Yes
481	3457	3457.0	135.09	135.1	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
482	17253	3450.6	1194.09	238.8	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
483	3447	3447.0	126.86	126.9	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
484	3439	3439.0	93.64	93.6	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
485	6872	3436.0	162.81	81.4	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
486	3432	3432.0	74.5	74.5	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
487	10283	3427.7	453.68	151.2	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
488	3427	3427.0	86.63	86.6	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
489	6847	3423.5	135.41	67.7	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
490	3422	3422.0	153.63	153.6	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
491	6789	3394.5	172.79	86.4	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
492	3386	3386.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W Kauzmann	Adv Protein Chem	1959	14404936	Yes
493	10145	3381.7	98.31	32.8	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C Greenwood, W M Hunter, J S Glover	Biochem J	1963	14097352	Yes
494	3380	3380.0	82.43	82.4	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
495	6752	3376.0	185.11	92.6	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
496	3373	3373.0	107.8	107.8	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
497	10112	3370.7	360.32	120.1	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
498	3361	3361.0	99.88	99.9	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
499	3358	3358.0	94.8	94.8	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
500	3357	3357.0	76.47	76.5	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
501	6700	3350.0	128.26	64.1	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
502	3349	3349.0	68.57	68.6	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
503	6692	3346.0	158.25	79.1	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
504	6680	3340.0	206.96	103.5	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
505	6664	3332.0	142.28	71.1	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
506	3326	3326.0	68.04	68.0	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
507	3320	3320.0	80.53	80.5	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
508	3308	3308.0	58.16	58.2	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
509	3304	3304.0	83.93	83.9	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
510	3299	3299.0	113.83	113.8	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A Yphantis	Biochemistry	1964	14155091	Yes
511	3284	3284.0	64.32	64.3	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
512	6562	3281.0	214.94	107.5	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
513	3280	3280.0	67.19	67.2	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
514	3277	3277.0	89.26	89.3	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
515	6534	3267.0	218.34	109.2	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
516	6527	3263.5	204.07	102.0	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
517	3263	3263.0	60.17	60.2	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
518	3259	3259.0	86.67	86.7	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
519	6512	3256.0	177.44	88.7	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
520	13020	3255.0	301.4	75.3	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
521	3254	3254.0	73.99	74.0	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
522	3251	3251.0	76.27	76.3	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
523	3241	3241.0	93.41	93.4	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
524	3239	3239.0	105.95	106.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
525	6470	3235.0	155.19	77.6	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
526	6462	3231.0	190.58	95.3	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
527	3229	3229.0	63.75	63.8	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
528	3227	3227.0	69.5	69.5	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
529	3221	3221.0	97.6	97.6	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
530	3219	3219.0	103.3	103.3	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
531	3204	3204.0	67.37	67.4	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
532	3200	3200.0	65.35	65.3	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
533	3197	3197.0	66.72	66.7	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
534	3168	3168.0	78.38	78.4	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
535	6327	3163.5	152.98	76.5	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
536	3159	3159.0	113.45	113.5	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
537	6309	3154.5	133.33	66.7	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
538	6309	3154.5	184.18	92.1	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
539	3151	3151.0	90.73	90.7	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
540	28312	3145.8	608.63	67.6	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
541	3143	3143.0	96.35	96.3	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
542	3141	3141.0	74.1	74.1	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
543	3139	3139.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O Ouchterlony	Prog Allergy	1958	13578996	Yes
544	6277	3138.5	195.87	97.9	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
545	3138	3138.0	82.28	82.3	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
546	6271	3135.5	205.84	102.9	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
547	12534	3133.5	475.97	119.0	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
548	3130	3130.0	108.99	109.0	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
549	3128	3128.0	65.88	65.9	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
550	6255	3127.5	101.6	50.8	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
551	3127	3127.0	121.02	121.0	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
552	3126	3126.0	65.98	66.0	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
553	9374	3124.7	264.61	88.2	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
554	6243	3121.5	151.77	75.9	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
555	3121	3121.0	26.68	26.7	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F Lyon	Nature	1961	13764598	Yes
556	6222	3111.0	156.81	78.4	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
557	9326	3108.7	194.4	64.8	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
558	6211	3105.5	53.65	26.8	The serial cultivation of human diploid cell strains.	L Hayflick, P S Moorhead	Exp Cell Res	1961	13905658	Yes
559	3102	3102.0	77.72	77.7	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
560	9285	3095.0	312.14	104.0	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
561	3092	3092.0	89.14	89.1	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
562	3091	3091.0	76.1	76.1	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
563	3091	3091.0	83.53	83.5	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
564	3083	3083.0	124.16	124.2	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
565	3083	3083.0	72.83	72.8	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
566	6156	3078.0	162.43	81.2	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
567	6153	3076.5	136.21	68.1	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
568	3074	3074.0	105.71	105.7	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
569	6142	3071.0	108.64	54.3	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
570	9213	3071.0	224.89	75.0	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
571	3070	3070.0	86.04	86.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
572	12261	3065.2	446.0	111.5	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
573	6127	3063.5	180.34	90.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
574	6100	3050.0	187.56	93.8	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
575	3044	3044.0	65.02	65.0	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
576	3041	3041.0	70.55	70.5	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
577	3036	3036.0	87.6	87.6	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
578	3035	3035.0	56.72	56.7	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
579	6070	3035.0	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S Reitman, S Frankel	Am J Clin Pathol	1957	13458125	Yes
580	3035	3035.0	73.31	73.3	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
581	24242	3030.2	525.35	65.7	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
582	3029	3029.0	117.26	117.3	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S Hakomori	J Biochem	1964	14135466	Yes
583	3029	3029.0	102.59	102.6	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
584	6048	3024.0	191.35	95.7	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
585	6034	3017.0	259.08	129.5	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
586	3011	3011.0	102.46	102.5	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
587	3009	3009.0	135.88	135.9	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
588	6017	3008.5	142.66	71.3	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
589	9025	3008.3	177.14	59.0	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
590	3007	3007.0	0.0	0.0	A study of fixation for electron microscopy.	G E Palade	J Exp Med	1952	14927794	Yes
591	12024	3006.0	284.33	71.1	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
592	8975	2991.7	207.37	69.1	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
593	2987	2987.0	58.96	59.0	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
594	2987	2987.0	86.09	86.1	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
595	5972	2986.0	134.78	67.4	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
596	8953	2984.3	169.14	56.4	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
597	2983	2983.0	111.12	111.1	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
598	2982	2982.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I Seldinger	Acta radiol	1953	13057644	Yes
599	5960	2980.0	221.26	110.6	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
600	2974	2974.0	52.93	52.9	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
601	2973	2973.0	68.84	68.8	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
602	5942	2971.0	124.92	62.5	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
603	2966	2966.0	529.23	529.2	Hallmarks of Cancer: New Dimensions.	Douglas Hanahan	Cancer Discov	2022	35022204	No
604	2965	2965.0	54.8	54.8	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
605	2964	2964.0	73.59	73.6	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
606	5919	2959.5	125.12	62.6	Emergence of scaling in random networks.	AL Barabasi, R Albert	Science	1999	10521342	Yes
607	20708	2958.3	774.69	110.7	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
608	2958	2958.0	91.23	91.2	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
609	2957	2957.0	94.0	94.0	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
610	26598	2955.3	841.52	93.5	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
611	8863	2954.3	288.9	96.3	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
612	2953	2953.0	89.8	89.8	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
613	5898	2949.0	185.31	92.7	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
614	8829	2943.0	242.3	80.8	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
615	2940	2940.0	66.11	66.1	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
616	5878	2939.0	244.52	122.3	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
617	32223	2929.4	671.03	61.0	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
618	5858	2929.0	152.2	76.1	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
619	2927	2927.0	68.92	68.9	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
620	2917	2917.0	47.28	47.3	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L Horn	Psychometrika	1965	14306381	Yes
621	8728	2909.3	200.98	67.0	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
622	2905	2905.0	65.55	65.5	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
623	8707	2902.3	440.43	146.8	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
624	2902	2902.0	43.72	43.7	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
625	2901	2901.0	101.37	101.4	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
626	2901	2901.0	0.0	0.0	The genetical structure of populations.	S Wright	Ann Eugen	1951	24540312	Yes
627	11602	2900.5	340.61	85.2	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
628	5799	2899.5	121.46	60.7	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
629	8692	2897.3	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J Havel, H A Eder, J H Bragdon	J Clin Invest	1955	13252080	Yes
630	5791	2895.5	161.78	80.9	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
631	2894	2894.0	68.43	68.4	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
632	2894	2894.0	70.38	70.4	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
633	2890	2890.0	67.44	67.4	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
634	5776	2888.0	178.13	89.1	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
635	2885	2885.0	59.95	60.0	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
636	2884	2884.0	86.25	86.2	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
637	5765	2882.5	152.12	76.1	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
638	2880	2880.0	29.15	29.1	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P Mitchell	Nature	1961	13771349	Yes
639	2879	2879.0	61.85	61.9	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
640	5750	2875.0	126.59	63.3	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
641	2868	2868.0	50.49	50.5	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A Gehan	Biometrika	1965	14341275	Yes
642	2867	2867.0	95.79	95.8	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
643	2866	2866.0	50.8	50.8	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
644	2861	2861.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C Schneider	J Biol Chem	1945	21005736	Yes
645	2860	2860.0	52.55	52.5	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
646	2852	2852.0	0.0	0.0	Notes on sugar determination.	M Smogyi	J Biol Chem	1952	14938350	Yes
647	5699	2849.5	248.47	124.2	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
648	8545	2848.3	241.98	80.7	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
649	2847	2847.0	56.31	56.3	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
650	2846	2846.0	61.06	61.1	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
651	2845	2845.0	55.81	55.8	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
652	2845	2845.0	71.63	71.6	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
653	2841	2841.0	55.64	55.6	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
654	2840	2840.0	105.77	105.8	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
655	2838	2838.0	0.0	0.0	A study of the adrenotropic receptors.	R P Ahlquist	Am J Physiol	1948	18882199	Yes
656	2836	2836.0	93.77	93.8	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
657	2823	2823.0	82.72	82.7	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
658	5645	2822.5	143.49	71.7	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
659	11287	2821.8	501.44	125.4	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
660	2821	2821.0	53.54	53.5	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
661	2821	2821.0	62.89	62.9	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
662	2813	2813.0	85.28	85.3	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
663	2812	2812.0	121.52	121.5	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
664	5622	2811.0	173.75	86.9	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
665	5617	2808.5	112.88	56.4	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
666	5609	2804.5	134.66	67.3	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
667	2804	2804.0	87.89	87.9	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
668	2802	2802.0	47.72	47.7	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
669	8404	2801.3	362.05	120.7	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
670	5598	2799.0	152.88	76.4	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
671	5596	2798.0	192.62	96.3	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
672	5594	2797.0	186.63	93.3	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
673	2794	2794.0	125.97	126.0	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
674	5585	2792.5	126.68	63.3	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
675	5578	2789.0	77.83	38.9	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G Martin, B N Ames	J Biol Chem	1961	13767412	Yes
676	5575	2787.5	265.83	132.9	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
677	8362	2787.3	190.13	63.4	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
678	8355	2785.0	205.06	68.4	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
679	11133	2783.2	298.71	74.7	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
680	2780	2780.0	70.25	70.2	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
681	2779	2779.0	65.15	65.2	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
682	5553	2776.5	109.81	54.9	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
683	11100	2775.0	337.59	84.4	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
684	2775	2775.0	112.08	112.1	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
685	2773	2773.0	108.95	109.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
686	2773	2773.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
687	2771	2771.0	69.71	69.7	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
688	2763	2763.0	77.6	77.6	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
689	2762	2762.0	69.68	69.7	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
690	5523	2761.5	199.78	99.9	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
691	2760	2760.0	116.89	116.9	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
692	5519	2759.5	130.46	65.2	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
693	2759	2759.0	65.6	65.6	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
694	5509	2754.5	133.48	66.7	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
695	5504	2752.0	127.72	63.9	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
696	5502	2751.0	151.92	76.0	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
697	5497	2748.5	91.01	45.5	A modified uronic acid carbazole reaction.	T Bitter, H M Muir	Anal Biochem	1962	13971270	Yes
698	2746	2746.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L Svennerholm	Biochim Biophys Acta	1957	13436486	Yes
699	10984	2746.0	1398.05	349.5	Cancer Statistics, 2021.	Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal	CA Cancer J Clin	2021	33433946	Yes
700	2745	2745.0	79.82	79.8	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
701	2743	2743.0	66.17	66.2	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
702	2740	2740.0	59.11	59.1	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
703	5472	2736.0	166.73	83.4	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
704	2734	2734.0	70.52	70.5	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
705	2730	2730.0	82.21	82.2	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
706	2729	2729.0	53.1	53.1	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
707	2726	2726.0	61.49	61.5	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
708	5444	2722.0	107.68	53.8	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
709	8160	2720.0	239.99	80.0	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
710	5439	2719.5	159.13	79.6	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
711	5438	2719.0	184.46	92.2	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
712	2719	2719.0	151.83	151.8	Hepatocellular Carcinoma.	Augusto Villanueva	N Engl J Med	2019	30970190	No
713	2718	2718.0	71.72	71.7	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
714	8141	2713.7	175.69	58.6	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
715	2711	2711.0	62.86	62.9	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
716	5402	2701.0	153.68	76.8	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
717	2698	2698.0	60.83	60.8	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
718	5380	2690.0	184.45	92.2	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
719	8056	2685.3	199.49	66.5	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
720	8055	2685.0	272.52	90.8	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
721	10737	2684.2	316.41	79.1	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
722	2683	2683.0	60.31	60.3	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
723	10731	2682.8	227.63	56.9	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
724	2678	2678.0	58.72	58.7	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
725	2670	2670.0	23.39	23.4	Satellite cell of skeletal muscle fibers.	A Mauro	J Biophys Biochem Cytol	1961	13768451	Yes
726	2669	2669.0	51.53	51.5	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
727	2665	2665.0	64.55	64.5	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
728	15979	2663.2	356.89	59.5	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
729	2658	2658.0	62.13	62.1	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
730	5312	2656.0	165.02	82.5	Accurate and simple analytic representation of the electron-gas correlation energy.	J P Perdew, Y Wang	Phys Rev B Condens Matter	1992	10001404	Yes
731	5305	2652.5	162.87	81.4	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
732	2649	2649.0	60.5	60.5	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
733	5290	2645.0	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D Watson, F H Crick	Nature	1953	13054692	Yes
734	2643	2643.0	83.15	83.2	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
735	2643	2643.0	103.25	103.2	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
736	2641	2641.0	82.13	82.1	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
737	2641	2641.0	59.59	59.6	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
738	5272	2636.0	209.7	104.8	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
739	2636	2636.0	81.48	81.5	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
740	5242	2621.0	142.48	71.2	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
741	2620	2620.0	106.63	106.6	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
742	2619	2619.0	65.17	65.2	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
743	5226	2613.0	117.37	58.7	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
744	2613	2613.0	106.2	106.2	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
745	2613	2613.0	75.09	75.1	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
746	5226	2613.0	107.33	53.7	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
747	2612	2612.0	121.26	121.3	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
748	5222	2611.0	101.79	50.9	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
749	5222	2611.0	0.0	0.0	Some quantitative uses of drug antagonists.	O Arunlakshana, H O Schild	Br J Pharmacol Chemother	1959	13651579	Yes
750	5215	2607.5	180.74	90.4	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
751	2603	2603.0	80.0	80.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
752	2596	2596.0	72.56	72.6	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
753	2592	2592.0	50.73	50.7	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
754	2590	2590.0	73.51	73.5	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
755	2589	2589.0	55.41	55.4	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
756	2588	2588.0	89.01	89.0	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
757	2584	2584.0	53.86	53.9	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
758	2583	2583.0	56.62	56.6	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
759	2581	2581.0	80.72	80.7	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
760	2581	2581.0	62.24	62.2	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
761	5157	2578.5	249.91	125.0	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J Silness, H Loe	Acta Odontol Scand	1964	14158464	Yes
762	2578	2578.0	73.62	73.6	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
763	5156	2578.0	160.2	80.1	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
764	5155	2577.5	167.47	83.7	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
765	5149	2574.5	73.32	36.7	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
766	2570	2570.0	71.68	71.7	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
767	2569	2569.0	61.97	62.0	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
768	2569	2569.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
769	2567	2567.0	71.12	71.1	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
770	5132	2566.0	126.61	63.3	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
771	2564	2564.0	68.65	68.7	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
772	2563	2563.0	36.06	36.1	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
773	2561	2561.0	129.21	129.2	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
774	2561	2561.0	52.24	52.2	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
775	2561	2561.0	97.45	97.5	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
776	2554	2554.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R Porter	Biochem J	1959	14434282	Yes
777	2547	2547.0	62.34	62.3	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
778	2546	2546.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O Smithies	Biochem J	1955	13276348	Yes
779	2546	2546.0	55.14	55.1	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
780	5067	2533.5	277.04	138.5	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
781	2533	2533.0	50.87	50.9	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
782	2528	2528.0	66.68	66.7	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
783	2527	2527.0	28.18	28.2	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S Boyden	J Exp Med	1962	13872176	Yes
784	7552	2517.3	197.63	65.9	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
785	2515	2515.0	77.24	77.2	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
786	2508	2508.0	73.83	73.8	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
787	5015	2507.5	220.56	110.3	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
788	5014	2507.0	116.06	58.0	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
789	7511	2503.7	198.07	66.0	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
790	2503	2503.0	77.15	77.2	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
791	7509	2503.0	203.55	67.9	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
792	10009	2502.2	404.04	101.0	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
793	4994	2497.0	156.33	78.2	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
794	2496	2496.0	44.87	44.9	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
795	4988	2494.0	99.99	50.0	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
796	7481	2493.7	186.86	62.3	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
797	4984	2492.0	181.8	90.9	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
798	4973	2486.5	128.83	64.4	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
799	4970	2485.0	141.49	70.7	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
800	2484	2484.0	61.9	61.9	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
801	4963	2481.5	119.58	59.8	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
802	4959	2479.5	147.21	73.6	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
803	7438	2479.3	192.3	64.1	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
804	4955	2477.5	96.29	48.1	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
805	2472	2472.0	112.1	112.1	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
806	4937	2468.5	122.24	61.1	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
807	2464	2464.0	92.42	92.4	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
808	2460	2460.0	81.52	81.5	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
809	2451	2451.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S Lennox	Virology	1955	13267987	Yes
810	2447	2447.0	121.31	121.3	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
811	4883	2441.5	140.9	70.5	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
812	2441	2441.0	61.52	61.5	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
813	2440	2440.0	47.31	47.3	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
814	2440	2440.0	65.59	65.6	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
815	7317	2439.0	208.16	69.4	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
816	2437	2437.0	54.24	54.2	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
817	4871	2435.5	108.22	54.1	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
818	9738	2434.5	253.98	63.5	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
819	2433	2433.0	77.89	77.9	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
820	2432	2432.0	57.89	57.9	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
821	4863	2431.5	103.45	51.7	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
822	4862	2431.0	129.5	64.8	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
823	2429	2429.0	109.84	109.8	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
824	4854	2427.0	120.83	60.4	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
825	2426	2426.0	53.14	53.1	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
826	2424	2424.0	46.18	46.2	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
827	2420	2420.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M Fitts	J Exp Psychol	1954	13174710	Yes
828	2413	2413.0	82.0	82.0	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
829	2409	2409.0	52.56	52.6	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
830	4815	2407.5	68.31	34.2	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H Loe, J Silness	Acta Odontol Scand	1963	14121956	Yes
831	2405	2405.0	50.56	50.6	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
832	4808	2404.0	92.88	46.4	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
833	2403	2403.0	52.6	52.6	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
834	4803	2401.5	156.55	78.3	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
835	2401	2401.0	53.78	53.8	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
836	2398	2398.0	43.76	43.8	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
837	2398	2398.0	75.76	75.8	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
838	4795	2397.5	94.15	47.1	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
839	2396	2396.0	57.61	57.6	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
840	2395	2395.0	79.7	79.7	Working memory.	A Baddeley	Science	1992	1736359	No
841	4784	2392.0	142.63	71.3	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
842	4782	2391.0	141.2	70.6	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
843	2389	2389.0	60.32	60.3	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
844	9545	2386.2	227.31	56.8	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
845	4766	2383.0	120.45	60.2	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
846	2383	2383.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
847	2379	2379.0	43.49	43.5	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
848	2376	2376.0	54.4	54.4	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
849	2375	2375.0	49.39	49.4	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
850	4740	2370.0	133.09	66.5	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
851	4739	2369.5	128.12	64.1	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	G Kresse, J Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
852	4733	2366.5	161.83	80.9	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
853	2365	2365.0	80.45	80.5	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
854	2365	2365.0	51.33	51.3	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
855	2364	2364.0	66.94	66.9	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
856	2364	2364.0	0.0	0.0	Muscle structure and theories of contraction.	A F Huxley	Prog Biophys Biophys Chem	1957	13485191	Yes
857	2362	2362.0	93.62	93.6	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
858	2360	2360.0	92.16	92.2	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
859	7077	2359.0	203.35	67.8	GSVA: gene set variation analysis for microarray and RNA-seq data.	Sonja Hänzelmann, Robert Castelo, Justin Guinney	BMC Bioinformatics	2013	23323831	Yes
860	4715	2357.5	205.31	102.7	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
861	2356	2356.0	61.98	62.0	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
862	7067	2355.7	154.2	51.4	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
863	4711	2355.5	113.12	56.6	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
864	4704	2352.0	97.55	48.8	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
865	4702	2351.0	103.17	51.6	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
866	2350	2350.0	96.85	96.8	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
867	2350	2350.0	127.37	127.4	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
868	2349	2349.0	51.5	51.5	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
869	4693	2346.5	127.48	63.7	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
870	7033	2344.3	69.92	23.3	On The Nature Of Allosteric Transitions: A Plausible Model.	J Monod, J Wyman, J P Changeux	J Mol Biol	1965	14343300	Yes
871	2343	2343.0	71.08	71.1	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
872	2343	2343.0	62.75	62.8	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
873	4676	2338.0	118.63	59.3	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
874	2338	2338.0	59.17	59.2	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
875	2337	2337.0	52.0	52.0	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
876	4672	2336.0	103.62	51.8	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
877	4664	2332.0	103.02	51.5	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
878	4663	2331.5	123.17	61.6	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
879	4662	2331.0	117.23	58.6	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
880	2330	2330.0	104.07	104.1	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
881	2327	2327.0	84.29	84.3	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
882	2324	2324.0	66.21	66.2	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
883	4645	2322.5	87.33	43.7	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
884	2322	2322.0	48.99	49.0	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
885	4638	2319.0	130.22	65.1	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
886	2319	2319.0	55.39	55.4	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
887	4638	2319.0	113.33	56.7	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
888	9275	2318.8	2060.1	515.0	Cancer statistics, 2022.	Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal	CA Cancer J Clin	2022	35020204	Yes
889	2318	2318.0	57.25	57.2	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
890	4636	2318.0	170.3	85.2	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
891	2316	2316.0	41.94	41.9	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
892	2314	2314.0	56.95	57.0	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
893	2313	2313.0	78.69	78.7	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
894	2313	2313.0	49.93	49.9	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
895	2311	2311.0	59.63	59.6	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
896	4620	2310.0	123.94	62.0	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
897	4616	2308.0	89.74	44.9	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
898	2307	2307.0	53.54	53.5	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
899	2305	2305.0	65.73	65.7	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
900	2305	2305.0	77.07	77.1	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
901	2304	2304.0	27.25	27.2	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T Higuchi	J Pharm Sci	1963	14088963	Yes
902	4606	2303.0	73.78	36.9	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
903	2301	2301.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G Bertani	J Bacteriol	1951	14888646	Yes
904	4601	2300.5	72.03	36.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
905	9201	2300.2	200.54	50.1	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
906	2300	2300.0	55.76	55.8	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
907	2299	2299.0	74.84	74.8	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
908	4594	2297.0	168.29	84.1	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
909	2297	2297.0	56.99	57.0	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
910	2295	2295.0	71.96	72.0	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
911	2295	2295.0	64.75	64.8	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
912	4585	2292.5	115.44	57.7	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
913	4584	2292.0	86.62	43.3	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
914	2292	2292.0	54.85	54.9	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
915	2291	2291.0	71.5	71.5	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
916	4582	2291.0	107.15	53.6	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
917	2288	2288.0	55.86	55.9	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
918	2287	2287.0	60.42	60.4	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
919	2286	2286.0	74.46	74.5	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
920	2282	2282.0	45.21	45.2	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
921	2277	2277.0	58.38	58.4	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
922	2276	2276.0	76.26	76.3	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
923	2275	2275.0	42.66	42.7	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
924	2275	2275.0	57.9	57.9	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
925	2274	2274.0	55.46	55.5	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
926	2274	2274.0	78.12	78.1	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
927	4547	2273.5	122.62	61.3	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
928	4539	2269.5	95.23	47.6	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
929	2269	2269.0	72.11	72.1	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
930	2265	2265.0	116.8	116.8	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
931	2264	2264.0	65.63	65.6	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
932	2261	2261.0	48.88	48.9	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
933	2261	2261.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A Clauss	Acta Haematol	1957	13434757	Yes
934	2260	2260.0	44.43	44.4	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
935	2260	2260.0	50.97	51.0	Application of a microtechnique to viral serological investigations.	J L Sever	J Immunol	1962	13910995	Yes
936	2260	2260.0	60.05	60.0	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
937	2258	2258.0	59.31	59.3	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
938	2256	2256.0	68.75	68.8	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
939	2256	2256.0	108.3	108.3	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
940	2252	2252.0	65.46	65.5	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
941	2251	2251.0	58.34	58.3	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
942	2249	2249.0	66.91	66.9	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
943	2247	2247.0	84.01	84.0	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
944	4493	2246.5	102.76	51.4	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
945	4490	2245.0	100.45	50.2	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
946	2244	2244.0	53.2	53.2	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
947	2244	2244.0	56.07	56.1	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
948	2242	2242.0	142.25	142.2	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
949	2241	2241.0	104.97	105.0	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
950	4478	2239.0	108.11	54.1	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
951	2238	2238.0	61.23	61.2	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
952	2237	2237.0	54.9	54.9	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
953	2236	2236.0	109.76	109.8	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
954	2235	2235.0	93.68	93.7	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
955	4469	2234.5	127.67	63.8	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
956	4466	2233.0	88.21	44.1	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
957	2233	2233.0	68.68	68.7	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
958	4463	2231.5	87.94	44.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
959	2231	2231.0	77.36	77.4	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
960	2231	2231.0	70.14	70.1	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
961	4461	2230.5	39.4	19.7	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
962	4458	2229.0	128.73	64.4	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
963	4458	2229.0	114.88	57.4	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
964	2226	2226.0	41.67	41.7	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
965	17803	2225.4	560.74	70.1	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
966	2225	2225.0	49.11	49.1	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
967	2225	2225.0	57.3	57.3	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
968	4447	2223.5	98.08	49.0	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
969	20006	2222.9	927.12	103.0	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
970	2222	2222.0	52.58	52.6	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
971	4434	2217.0	112.97	56.5	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
972	2213	2213.0	48.86	48.9	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
973	2213	2213.0	89.81	89.8	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
974	2210	2210.0	87.39	87.4	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
975	8835	2208.8	178.9	44.7	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
976	4417	2208.5	99.15	49.6	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
977	2207	2207.0	65.78	65.8	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
978	2207	2207.0	148.56	148.6	Obesity: global epidemiology and pathogenesis.	Matthias Blüher	Nat Rev Endocrinol	2019	30814686	No
979	2205	2205.0	83.72	83.7	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
980	2202	2202.0	59.53	59.5	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
981	2201	2201.0	61.63	61.6	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
982	6600	2200.0	254.91	85.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
983	2198	2198.0	55.0	55.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
984	2197	2197.0	68.11	68.1	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
985	4394	2197.0	95.66	47.8	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
986	4393	2196.5	105.77	52.9	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
987	2196	2196.0	71.53	71.5	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
988	2192	2192.0	78.98	79.0	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
989	2192	2192.0	48.61	48.6	Chemokines.	B J Rollins	Blood	1997	9242519	No
990	2192	2192.0	61.62	61.6	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
991	2190	2190.0	46.7	46.7	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
992	6570	2190.0	194.62	64.9	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
993	2187	2187.0	53.01	53.0	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
994	8748	2187.0	456.09	114.0	fastp: an ultra-fast all-in-one FASTQ preprocessor.	Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu	Bioinformatics	2018	30423086	Yes
995	2184	2184.0	53.76	53.8	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
996	8735	2183.8	209.9	52.5	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
997	6549	2183.0	181.25	60.4	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
998	4360	2180.0	76.01	38.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
999	4359	2179.5	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B Scoville, B Milner	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
1000	2179	2179.0	54.43	54.4	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
1001	2177	2177.0	90.62	90.6	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
1002	2175	2175.0	66.11	66.1	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
1003	6524	2174.7	203.43	67.8	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1004	2172	2172.0	60.4	60.4	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
1005	2172	2172.0	58.63	58.6	The episodic buffer: a new component of working memory?	A Baddeley	Trends Cogn Sci	2000	11058819	Yes
1006	4343	2171.5	103.25	51.6	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
1007	2171	2171.0	48.31	48.3	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1008	2169	2169.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H Pennes	J Appl Physiol	1948	18887578	Yes
1009	2169	2169.0	62.46	62.5	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1010	4337	2168.5	147.25	73.6	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1011	2165	2165.0	56.44	56.4	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
1012	2164	2164.0	71.54	71.5	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
1013	4325	2162.5	148.6	74.3	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
1014	2160	2160.0	55.45	55.5	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
1015	2159	2159.0	41.89	41.9	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
1016	2159	2159.0	55.06	55.1	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
1017	2155	2155.0	49.03	49.0	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
1018	2152	2152.0	31.19	31.2	Sedimentation Studies Of The Size And Shape Of Dna.	F W Studier	J Mol Biol	1965	14290352	Yes
1019	8600	2150.0	184.57	46.1	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1020	2147	2147.0	45.79	45.8	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
1021	2147	2147.0	69.29	69.3	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
1022	6438	2146.0	185.85	61.9	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
1023	4292	2146.0	181.77	90.9	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1024	2143	2143.0	39.94	39.9	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
1025	4282	2141.0	100.46	50.2	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
1026	2141	2141.0	49.45	49.5	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
1027	2140	2140.0	115.48	115.5	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1028	2139	2139.0	64.98	65.0	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1029	4276	2138.0	73.43	36.7	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H Venable, R Coggeshall	J Cell Biol	1965	14287192	Yes
1030	2138	2138.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z Dische	J Biol Chem	1947	20281638	Yes
1031	4273	2136.5	103.6	51.8	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1032	2136	2136.0	48.51	48.5	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1033	6408	2136.0	131.38	43.8	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
1034	4272	2136.0	106.96	53.5	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
1035	12810	2135.0	286.2	47.7	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
1036	2135	2135.0	51.21	51.2	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
1037	2132	2132.0	92.39	92.4	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1038	4263	2131.5	122.95	61.5	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
1039	2131	2131.0	64.9	64.9	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
1040	4260	2130.0	327.75	163.9	The biology, function, and biomedical applications of exosomes.	Raghu Kalluri, Valerie S LeBleu	Science	2020	32029601	No
1041	4257	2128.5	80.63	40.3	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
1042	4256	2128.0	110.95	55.5	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1043	6380	2126.7	146.28	48.8	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
1044	2125	2125.0	42.14	42.1	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
1045	4248	2124.0	83.27	41.6	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1046	6368	2122.7	161.22	53.7	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1047	6365	2121.7	130.42	43.5	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1048	4241	2120.5	116.23	58.1	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1049	6361	2120.3	279.92	93.3	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
1050	12719	2119.8	681.19	113.5	DADA2: High-resolution sample inference from Illumina amplicon data.	Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes	Nat Methods	2016	27214047	Yes
1051	6355	2118.3	119.06	39.7	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
1052	6354	2118.0	149.21	49.7	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1053	4235	2117.5	134.51	67.3	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
1054	2116	2116.0	64.09	64.1	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
1055	4228	2114.0	121.61	60.8	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
1056	2113	2113.0	44.56	44.6	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
1057	2113	2113.0	35.31	35.3	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D Aminoff	Biochem J	1961	13860975	Yes
1058	4222	2111.0	82.53	41.3	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
1059	4219	2109.5	127.29	63.6	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1060	6316	2105.3	192.65	64.2	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1061	4210	2105.0	106.89	53.4	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
1062	2103	2103.0	52.53	52.5	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1063	33640	2102.5	1081.82	67.6	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
1064	2101	2101.0	50.73	50.7	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1065	2100	2100.0	61.1	61.1	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
1066	2100	2100.0	126.9	126.9	Toward understanding the origin and evolution of cellular organisms.	Minoru Kanehisa	Protein Sci	2019	31441146	No
1067	2098	2098.0	37.92	37.9	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
1068	2097	2097.0	76.12	76.1	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
1069	2095	2095.0	49.33	49.3	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
1070	2095	2095.0	83.52	83.5	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
1071	2095	2095.0	74.7	74.7	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
1072	2094	2094.0	48.82	48.8	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1073	2094	2094.0	58.23	58.2	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1074	4188	2094.0	147.67	73.8	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
1075	8367	2091.8	304.79	76.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1076	4182	2091.0	177.66	88.8	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1077	2087	2087.0	42.43	42.4	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
1078	2081	2081.0	95.99	96.0	Method For Assay Of Intestinal Disaccharidases.	A Dahlqvist	Anal Biochem	1964	14106916	Yes
1079	4160	2080.0	108.92	54.5	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1080	2080	2080.0	45.47	45.5	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1081	2078	2078.0	47.18	47.2	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1082	4155	2077.5	100.61	50.3	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1083	4150	2075.0	82.03	41.0	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
1084	6224	2074.7	185.03	61.7	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
1085	2073	2073.0	50.52	50.5	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1086	2073	2073.0	53.16	53.2	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
1087	2072	2072.0	59.63	59.6	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1088	4141	2070.5	81.72	40.9	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
1089	4137	2068.5	185.03	92.5	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1090	2068	2068.0	71.25	71.2	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1091	2068	2068.0	93.82	93.8	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
1092	8258	2064.5	392.94	98.2	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1093	4126	2063.0	118.41	59.2	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1094	8244	2061.0	270.17	67.5	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1095	4122	2061.0	35.59	17.8	Genetic regulatory mechanisms in the synthesis of proteins.	F Jacob, J Monod	J Mol Biol	1961	13718526	Yes
1096	2061	2061.0	37.91	37.9	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C Skou	Physiol Rev	1965	14337569	No
1097	4121	2060.5	109.44	54.7	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1098	4120	2060.0	86.01	43.0	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1099	4120	2060.0	80.78	40.4	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1100	2060	2060.0	50.65	50.6	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1101	2057	2057.0	42.48	42.5	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1102	10282	2056.4	239.18	47.8	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1103	2056	2056.0	52.77	52.8	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
1104	2055	2055.0	41.42	41.4	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1105	4106	2053.0	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R Dulbecco, M Vogt	J Exp Med	1954	13130792	Yes
1106	4103	2051.5	119.08	59.5	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
1107	2051	2051.0	18.79	18.8	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W Cleland	Biochim Biophys Acta	1963	14021667	Yes
1108	2051	2051.0	59.12	59.1	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W Littlefield	Science	1964	14168277	Yes
1109	4101	2050.5	100.96	50.5	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1110	4100	2050.0	129.94	65.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1111	2050	2050.0	64.98	65.0	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1112	6148	2049.3	201.91	67.3	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1113	2048	2048.0	47.93	47.9	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1114	2048	2048.0	39.61	39.6	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1115	4094	2047.0	110.85	55.4	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1116	6128	2042.7	197.21	65.7	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1117	2042	2042.0	56.66	56.7	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
1118	2041	2041.0	47.77	47.8	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1119	4081	2040.5	77.57	38.8	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1120	4080	2040.0	104.6	52.3	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1121	2039	2039.0	72.78	72.8	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
1122	2038	2038.0	41.73	41.7	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1123	4067	2033.5	176.46	88.2	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1124	6095	2031.7	268.93	89.6	Fast and sensitive protein alignment using DIAMOND.	Benjamin Buchfink, Chao Xie, Daniel H Huson	Nat Methods	2015	25402007	Yes
1125	4062	2031.0	98.38	49.2	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1126	2031	2031.0	51.84	51.8	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1127	4059	2029.5	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F Beers, I W Sizer	J Biol Chem	1952	14938361	Yes
1128	4053	2026.5	94.87	47.4	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
1129	2025	2025.0	62.36	62.4	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
1130	2024	2024.0	47.57	47.6	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
1131	4048	2024.0	79.59	39.8	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1132	6071	2023.7	228.68	76.2	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1133	2023	2023.0	79.33	79.3	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1134	12134	2022.3	376.64	62.8	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
1135	2021	2021.0	44.23	44.2	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1136	2021	2021.0	52.51	52.5	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
1137	2021	2021.0	59.89	59.9	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1138	2020	2020.0	39.03	39.0	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
1139	4038	2019.0	97.13	48.6	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1140	2015	2015.0	60.45	60.5	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1141	6044	2014.7	257.61	85.9	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
1142	2014	2014.0	55.23	55.2	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1143	8054	2013.5	302.15	75.5	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1144	2010	2010.0	58.27	58.3	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1145	2009	2009.0	46.78	46.8	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1146	2008	2008.0	96.03	96.0	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1147	2008	2008.0	41.62	41.6	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
1148	2008	2008.0	0.0	0.0	Antigen-antibody reactions in gels.	O Ouchterlony	Acta Pathol Microbiol Scand	1949	18143039	Yes
1149	2005	2005.0	34.81	34.8	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
1150	2005	2005.0	42.38	42.4	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1151	6014	2004.7	181.65	60.6	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
1152	2004	2004.0	50.27	50.3	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1153	2003	2003.0	38.59	38.6	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1154	2001	2001.0	83.29	83.3	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1155	2000	2000.0	40.66	40.7	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
1156	1999	1999.0	36.65	36.6	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
1157	1999	1999.0	50.95	51.0	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1158	1998	1998.0	43.82	43.8	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1159	1998	1998.0	39.45	39.5	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1160	1997	1997.0	22.12	22.1	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V Neel	Am J Hum Genet	1962	13937884	Yes
1161	1995	1995.0	55.83	55.8	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1162	7975	1993.8	326.11	81.5	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1163	1993	1993.0	79.84	79.8	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
1164	1992	1992.0	42.37	42.4	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1165	1990	1990.0	0.0	0.0	On respiratory impairment in cancer cells.	O Warburg	Science	1956	13351639	Yes
1166	1990	1990.0	47.82	47.8	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1167	1990	1990.0	68.59	68.6	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1168	1988	1988.0	41.58	41.6	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1169	3975	1987.5	85.51	42.8	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1170	1987	1987.0	54.74	54.7	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1171	1987	1987.0	40.74	40.7	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
1172	7945	1986.2	235.02	58.8	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1173	1986	1986.0	66.01	66.0	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1174	3972	1986.0	90.92	45.5	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1175	3970	1985.0	88.01	44.0	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1176	3969	1984.5	86.26	43.1	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
1177	7938	1984.5	504.0	126.0	Rayyan-a web and mobile app for systematic reviews.	Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid	Syst Rev	2016	27919275	Yes
1178	13889	1984.1	306.24	43.7	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1179	1984	1984.0	43.29	43.3	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1180	3967	1983.5	90.19	45.1	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1181	7929	1982.2	193.1	48.3	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1182	1978	1978.0	48.54	48.5	Negative refraction makes a perfect lens	J B Pendry	Phys Rev Lett	2000	11041972	Yes
1183	1976	1976.0	38.5	38.5	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1184	3950	1975.0	98.01	49.0	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1185	3948	1974.0	115.99	58.0	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1186	1973	1973.0	54.19	54.2	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1187	3946	1973.0	116.9	58.5	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1188	1973	1973.0	38.93	38.9	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1189	13811	1973.0	315.52	45.1	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1190	1972	1972.0	52.72	52.7	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1191	3944	1972.0	117.39	58.7	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
1192	1972	1972.0	61.51	61.5	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1193	3943	1971.5	86.87	43.4	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1194	3943	1971.5	89.46	44.7	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1195	1970	1970.0	117.54	117.5	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
1196	1968	1968.0	90.72	90.7	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1197	3936	1968.0	108.14	54.1	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1198	3936	1968.0	523.97	262.0	Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2021	33885785	Yes
1199	3935	1967.5	109.6	54.8	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1200	1967	1967.0	70.36	70.4	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1201	21635	1966.8	538.1	48.9	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1202	1965	1965.0	49.2	49.2	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1203	1963	1963.0	34.87	34.9	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1204	1963	1963.0	62.72	62.7	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1205	3926	1963.0	132.95	66.5	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
1206	5886	1962.0	191.33	63.8	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1207	3923	1961.5	96.67	48.3	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1208	1961	1961.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
1209	1960	1960.0	57.79	57.8	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1210	1959	1959.0	47.29	47.3	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1211	1957	1957.0	61.27	61.3	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1212	3912	1956.0	139.71	69.9	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1213	3911	1955.5	125.58	62.8	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
1214	3908	1954.0	135.59	67.8	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1215	1953	1953.0	45.0	45.0	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1216	1953	1953.0	45.9	45.9	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1217	1952	1952.0	60.19	60.2	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1218	1951	1951.0	41.02	41.0	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1219	1951	1951.0	62.26	62.3	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1220	1951	1951.0	47.92	47.9	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1221	1950	1950.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R Steele	Ann N Y Acad Sci	1959	13833973	Yes
1222	1949	1949.0	61.7	61.7	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1223	1949	1949.0	0.0	0.0	On estimating the relation between blood group and disease.	B Woolf	Ann Hum Genet	1955	14388528	Yes
1224	1947	1947.0	79.63	79.6	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1225	3894	1947.0	65.25	32.6	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1226	1947	1947.0	34.17	34.2	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1227	3894	1947.0	144.41	72.2	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R Morrison, L M Smith	J Lipid Res	1964	14221106	Yes
1228	5834	1944.7	107.28	35.8	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1229	3888	1944.0	131.05	65.5	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1230	5829	1943.0	120.17	40.1	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1231	1942	1942.0	61.14	61.1	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1232	1942	1942.0	37.58	37.6	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1233	1942	1942.0	38.95	39.0	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1234	3883	1941.5	94.58	47.3	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1235	1941	1941.0	37.01	37.0	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1236	1940	1940.0	39.76	39.8	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1237	1940	1940.0	39.34	39.3	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1238	1940	1940.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V Boyden	J Exp Med	1951	14803635	Yes
1239	1939	1939.0	64.4	64.4	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1240	1937	1937.0	41.15	41.1	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1241	1935	1935.0	49.86	49.9	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1242	1934	1934.0	60.29	60.3	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1243	1932	1932.0	55.28	55.3	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1244	1932	1932.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A Sholl	J Anat	1953	13117757	Yes
1245	1931	1931.0	57.48	57.5	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1246	1930	1930.0	42.21	42.2	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
1247	3857	1928.5	90.25	45.1	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1248	1927	1927.0	42.74	42.7	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1249	3853	1926.5	94.76	47.4	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1250	1926	1926.0	50.58	50.6	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1251	1926	1926.0	99.0	99.0	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1252	3850	1925.0	102.76	51.4	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1253	1925	1925.0	42.99	43.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1254	1924	1924.0	124.33	124.3	High-performance medicine: the convergence of human and artificial intelligence.	Eric J Topol	Nat Med	2019	30617339	No
1255	1923	1923.0	23.2	23.2	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1256	3846	1923.0	122.73	61.4	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1257	3842	1921.0	73.59	36.8	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1258	1920	1920.0	83.56	83.6	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1259	7677	1919.2	298.98	74.7	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1260	1919	1919.0	46.52	46.5	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1261	1918	1918.0	45.67	45.7	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1262	5752	1917.3	189.32	63.1	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1263	1917	1917.0	41.56	41.6	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1264	1916	1916.0	46.98	47.0	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1265	1916	1916.0	33.8	33.8	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1266	1915	1915.0	39.13	39.1	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1267	3829	1914.5	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J Vogel, D M Bonner	J Biol Chem	1956	13278318	Yes
1268	1914	1914.0	40.01	40.0	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1269	1914	1914.0	54.82	54.8	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1270	1914	1914.0	42.16	42.2	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1271	1913	1913.0	56.21	56.2	Inhibited spontaneous emission in solid-state physics and electronics.	E Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1272	1913	1913.0	45.15	45.1	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1273	3825	1912.5	122.01	61.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1274	7649	1912.2	188.65	47.2	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1275	3823	1911.5	120.23	60.1	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1276	1911	1911.0	46.14	46.1	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1277	3819	1909.5	98.33	49.2	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	S Nie, S R Emory	Science	1997	9027306	Yes
1278	3818	1909.0	84.91	42.5	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1279	1909	1909.0	40.61	40.6	The etiology of chondromalacia patellae.	R E Outerbridge	J Bone Joint Surg Br	1961	14038135	Yes
1280	3817	1908.5	130.23	65.1	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1281	1908	1908.0	46.26	46.3	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1282	1908	1908.0	53.4	53.4	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1283	1907	1907.0	62.9	62.9	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1284	1906	1906.0	44.18	44.2	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1285	1902	1902.0	54.3	54.3	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1286	1902	1902.0	43.12	43.1	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1287	1902	1902.0	112.75	112.8	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
1288	1901	1901.0	58.61	58.6	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
1289	1900	1900.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H Hirs	J Biol Chem	1956	13319283	Yes
1290	7599	1899.8	185.64	46.4	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1291	3799	1899.5	114.94	57.5	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1292	1899	1899.0	63.03	63.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1293	5696	1898.7	166.2	55.4	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1294	1898	1898.0	52.77	52.8	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1295	5692	1897.3	341.18	113.7	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1296	1894	1894.0	41.16	41.2	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1297	3786	1893.0	118.19	59.1	Efficient pseudopotentials for plane-wave calculations.	N Troullier, J L Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1298	5676	1892.0	145.14	48.4	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1299	1892	1892.0	53.38	53.4	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1300	1890	1890.0	16.08	16.1	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1301	5670	1890.0	153.08	51.0	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón	Bioinformatics	2009	19505945	Yes
1302	1889	1889.0	45.57	45.6	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1303	3778	1889.0	87.07	43.5	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1304	3777	1888.5	85.02	42.5	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1305	1888	1888.0	59.28	59.3	Receiver operating characteristic curve in diagnostic test assessment.	Jayawant N Mandrekar	J Thorac Oncol	2010	20736804	No
1306	3775	1887.5	107.0	53.5	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1307	1887	1887.0	59.95	60.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1308	1887	1887.0	58.83	58.8	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1309	1887	1887.0	64.94	64.9	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1310	1884	1884.0	53.87	53.9	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1311	3767	1883.5	117.2	58.6	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1312	15065	1883.1	367.92	46.0	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1313	1882	1882.0	69.33	69.3	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1314	7527	1881.8	182.1	45.5	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1315	3761	1880.5	89.67	44.8	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1316	3761	1880.5	129.02	64.5	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1317	1880	1880.0	69.37	69.4	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
1318	7518	1879.5	252.37	63.1	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1319	5638	1879.3	196.82	65.6	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1320	1879	1879.0	78.84	78.8	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1321	1879	1879.0	49.88	49.9	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1322	1879	1879.0	50.91	50.9	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1323	3754	1877.0	86.11	43.1	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1324	1876	1876.0	41.12	41.1	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1325	1873	1873.0	90.57	90.6	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1326	1873	1873.0	39.09	39.1	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1327	5618	1872.7	450.44	150.1	An interactive web-based dashboard to track COVID-19 in real time.	Ensheng Dong, Hongru Du, Lauren Gardner	Lancet Infect Dis	2020	32087114	Yes
1328	1872	1872.0	68.43	68.4	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1329	3743	1871.5	68.14	34.1	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1330	3740	1870.0	125.64	62.8	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1331	1869	1869.0	73.48	73.5	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1332	1869	1869.0	39.96	40.0	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1333	5604	1868.0	125.52	41.8	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1334	1867	1867.0	50.8	50.8	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1335	3730	1865.0	78.45	39.2	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1336	9324	1864.8	221.47	44.3	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1337	13039	1862.7	464.95	66.4	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1338	1861	1861.0	37.38	37.4	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1339	1861	1861.0	41.93	41.9	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1340	1861	1861.0	60.11	60.1	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1341	1861	1861.0	48.9	48.9	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1342	1860	1860.0	47.71	47.7	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1343	1860	1860.0	41.47	41.5	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1344	3719	1859.5	103.16	51.6	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1345	3719	1859.5	78.73	39.4	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1346	1858	1858.0	51.14	51.1	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1347	3716	1858.0	76.8	38.4	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1348	1858	1858.0	43.87	43.9	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1349	1855	1855.0	48.6	48.6	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1350	1854	1854.0	41.62	41.6	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1351	1853	1853.0	45.17	45.2	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1352	3700	1850.0	76.77	38.4	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1353	1848	1848.0	48.56	48.6	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1354	5543	1847.7	138.69	46.2	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1355	3695	1847.5	134.16	67.1	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1356	3694	1847.0	151.42	75.7	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
1357	7383	1845.8	178.66	44.7	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1358	14764	1845.5	414.55	51.8	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1359	3691	1845.5	52.8	26.4	Immunoassay of insulin with insulin-antibody precipitate.	C N Hales, P J Randle	Biochem J	1963	13952078	Yes
1360	1845	1845.0	0.0	0.0	Cognitive maps in rats and men.	E C Tolman	Psychol Rev	1948	18870876	Yes
1361	3689	1844.5	133.09	66.5	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1362	14747	1843.4	613.31	76.7	The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.	Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner	Nucleic Acids Res	2013	23193283	Yes
1363	1843	1843.0	44.02	44.0	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1364	5526	1842.0	122.15	40.7	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1365	3683	1841.5	142.38	71.2	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
1366	3682	1841.0	82.02	41.0	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1367	1841	1841.0	84.63	84.6	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1368	1840	1840.0	55.68	55.7	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1369	1840	1840.0	52.7	52.7	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1370	3679	1839.5	129.68	64.8	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1371	1839	1839.0	45.07	45.1	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1372	3677	1838.5	99.76	49.9	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1373	1838	1838.0	41.48	41.5	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1374	3675	1837.5	338.97	169.5	WHO Declares COVID-19 a Pandemic.	Domenico Cucinotta, Maurizio Vanelli	Acta Biomed	2020	32191675	Yes
1375	7349	1837.2	341.33	85.3	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1376	3674	1837.0	120.51	60.3	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1377	1836	1836.0	50.1	50.1	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1378	7339	1834.8	203.66	50.9	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1379	3669	1834.5	110.49	55.2	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1380	1834	1834.0	68.23	68.2	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1381	3667	1833.5	105.12	52.6	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1382	1833	1833.0	35.45	35.5	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1383	1833	1833.0	36.41	36.4	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1384	3666	1833.0	154.43	77.2	Cancer immunotherapy using checkpoint blockade.	Antoni Ribas, Jedd D Wolchok	Science	2018	29567705	No
1385	5497	1832.3	121.19	40.4	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1386	3664	1832.0	76.33	38.2	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1387	1831	1831.0	66.1	66.1	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1388	1831	1831.0	54.25	54.2	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1389	1830	1830.0	17.74	17.7	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A Robinson	IEEE Trans Biomed Eng	1963	14121113	Yes
1390	1829	1829.0	44.48	44.5	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1391	3654	1827.0	87.73	43.9	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1392	1827	1827.0	36.76	36.8	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1393	1824	1824.0	50.5	50.5	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1394	1824	1824.0	41.39	41.4	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1395	1823	1823.0	70.09	70.1	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1396	10930	1821.7	318.95	53.2	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1397	1817	1817.0	39.94	39.9	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1398	1814	1814.0	49.42	49.4	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1399	1813	1813.0	51.04	51.0	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1400	3624	1812.0	87.55	43.8	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1401	3623	1811.5	92.41	46.2	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1402	1811	1811.0	54.69	54.7	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1403	1811	1811.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C Skou	Biochim Biophys Acta	1957	13412736	Yes
1404	1811	1811.0	55.06	55.1	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1405	5431	1810.3	102.82	34.3	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1406	1808	1808.0	19.96	20.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S Cohen	J Biol Chem	1962	13880319	Yes
1407	1807	1807.0	58.95	59.0	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1408	1803	1803.0	42.57	42.6	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1409	1803	1803.0	66.15	66.2	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1410	3605	1802.5	102.62	51.3	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1411	1802	1802.0	44.94	44.9	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1412	9010	1802.0	235.14	47.0	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1413	1802	1802.0	75.82	75.8	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
1414	5405	1801.7	112.66	37.6	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	J H Zhang, T D Chung, K R Oldenburg	J Biomol Screen	1999	10838414	Yes
1415	3601	1800.5	92.65	46.3	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1416	5397	1799.0	165.14	55.0	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1417	1799	1799.0	48.86	48.9	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1418	1799	1799.0	49.82	49.8	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1419	1798	1798.0	56.51	56.5	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1420	3596	1798.0	123.35	61.7	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1421	1797	1797.0	52.68	52.7	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
1422	1797	1797.0	53.08	53.1	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1423	5387	1795.7	142.07	47.4	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1424	1795	1795.0	62.48	62.5	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1425	1795	1795.0	42.43	42.4	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1426	7180	1795.0	273.75	68.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
1427	1794	1794.0	48.16	48.2	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1428	1794	1794.0	35.8	35.8	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1429	1794	1794.0	0.0	0.0	The measurement of volume changes in human limbs.	R J Whitney	J Physiol	1953	13085295	Yes
1430	3586	1793.0	181.3	90.7	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1431	1793	1793.0	43.96	44.0	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1432	3586	1793.0	249.34	124.7	Interactive Tree Of Life (iTOL) v4: recent updates and new developments.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2019	30931475	Yes
1433	1792	1792.0	47.88	47.9	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1434	3583	1791.5	116.02	58.0	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1435	1791	1791.0	102.5	102.5	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1436	3581	1790.5	110.49	55.2	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1437	1790	1790.0	36.64	36.6	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1438	3579	1789.5	159.96	80.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1439	1789	1789.0	59.17	59.2	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1440	1789	1789.0	36.14	36.1	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1441	3576	1788.0	85.94	43.0	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1442	3576	1788.0	86.26	43.1	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1443	1786	1786.0	42.9	42.9	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1444	3571	1785.5	98.97	49.5	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1445	1785	1785.0	58.36	58.4	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1446	3570	1785.0	126.01	63.0	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1447	1784	1784.0	53.24	53.2	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1448	7111	1777.8	138.24	34.6	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1449	3555	1777.5	88.05	44.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1450	1777	1777.0	32.74	32.7	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1451	1777	1777.0	36.81	36.8	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1452	1777	1777.0	38.67	38.7	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1453	1777	1777.0	59.36	59.4	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1454	5329	1776.3	140.53	46.8	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1455	1776	1776.0	57.94	57.9	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1456	1776	1776.0	18.52	18.5	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1457	3552	1776.0	82.68	41.3	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1458	1774	1774.0	36.16	36.2	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1459	1773	1773.0	36.22	36.2	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1460	1772	1772.0	46.43	46.4	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1461	12403	1771.9	299.84	42.8	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1462	1771	1771.0	71.23	71.2	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1463	1770	1770.0	58.68	58.7	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1464	3538	1769.0	109.47	54.7	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1465	3537	1768.5	88.55	44.3	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1466	10609	1768.2	318.23	53.0	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1467	1768	1768.0	111.3	111.3	The Global Epidemic of the Metabolic Syndrome.	Mohammad G Saklayen	Curr Hypertens Rep	2018	29480368	No
1468	5303	1767.7	223.23	74.4	The behaviour change wheel: a new method for characterising and designing behaviour change interventions.	Susan Michie, Maartje M van Stralen, Robert West	Implement Sci	2011	21513547	No
1469	3535	1767.5	128.28	64.1	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
1470	1767	1767.0	60.66	60.7	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1471	1766	1766.0	55.62	55.6	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1472	1766	1766.0	46.35	46.4	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1473	1765	1765.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S Hestrin	J Biol Chem	1949	18133390	Yes
1474	1763	1763.0	39.05	39.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1475	17627	1762.7	552.43	55.2	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1476	3523	1761.5	73.33	36.7	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1477	8804	1760.8	293.5	58.7	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
1478	1760	1760.0	46.72	46.7	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1479	3520	1760.0	74.78	37.4	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1480	1760	1760.0	42.39	42.4	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1481	1759	1759.0	51.02	51.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1482	1759	1759.0	47.6	47.6	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1483	1758	1758.0	35.82	35.8	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1484	1758	1758.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D Simpson	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1485	3515	1757.5	45.54	22.8	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1486	3514	1757.0	157.33	78.7	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
1487	3512	1756.0	86.46	43.2	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1488	3512	1756.0	79.35	39.7	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1489	1754	1754.0	40.76	40.8	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1490	1754	1754.0	0.0	0.0	A personality scale of manifest anxiety.	J A Taylor	J Abnorm Psychol	1953	13052352	Yes
1491	1753	1753.0	40.06	40.1	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1492	3506	1753.0	69.96	35.0	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
1493	3505	1752.5	99.65	49.8	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1494	1751	1751.0	65.38	65.4	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1495	1751	1751.0	61.09	61.1	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1496	1751	1751.0	41.59	41.6	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1497	1750	1750.0	42.55	42.5	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1498	1750	1750.0	43.65	43.6	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1499	1749	1749.0	47.18	47.2	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1500	3496	1748.0	92.62	46.3	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1501	1748	1748.0	38.63	38.6	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1502	3493	1746.5	82.8	41.4	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1503	1746	1746.0	41.69	41.7	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1504	1746	1746.0	44.43	44.4	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1505	3492	1746.0	69.18	34.6	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
1506	1746	1746.0	65.57	65.6	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1507	3489	1744.5	136.03	68.0	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1508	6973	1743.2	293.88	73.5	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1509	1743	1743.0	37.79	37.8	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1510	1742	1742.0	52.67	52.7	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1511	1742	1742.0	71.77	71.8	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1512	3484	1742.0	92.18	46.1	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1513	5225	1741.7	118.06	39.4	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1514	3482	1741.0	139.21	69.6	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1515	3482	1741.0	73.0	36.5	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1516	3481	1740.5	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T Campbell, D W Fiske	Psychol Bull	1959	13634291	Yes
1517	1740	1740.0	32.86	32.9	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1518	1740	1740.0	66.05	66.0	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
1519	6953	1738.2	135.77	33.9	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1520	3476	1738.0	178.81	89.4	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1521	1738	1738.0	56.35	56.4	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1522	3475	1737.5	103.81	51.9	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1523	3473	1736.5	95.3	47.6	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1524	12155	1736.4	406.93	58.1	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
1525	1736	1736.0	40.56	40.6	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1526	3469	1734.5	87.32	43.7	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
1527	1734	1734.0	62.54	62.5	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1528	1734	1734.0	54.31	54.3	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1529	1733	1733.0	73.76	73.8	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1530	1733	1733.0	41.99	42.0	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1531	3465	1732.5	89.43	44.7	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1532	1732	1732.0	49.96	50.0	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1533	3463	1731.5	149.46	74.7	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1534	5194	1731.3	112.58	37.5	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1535	3462	1731.0	94.16	47.1	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1536	1731	1731.0	56.89	56.9	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1537	3462	1731.0	90.74	45.4	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1538	1731	1731.0	33.46	33.5	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1539	1730	1730.0	40.92	40.9	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1540	1729	1729.0	39.32	39.3	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1541	1729	1729.0	59.44	59.4	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1542	3457	1728.5	132.72	66.4	The Emerging Hallmarks of Cancer Metabolism.	Natalya N Pavlova, Craig B Thompson	Cell Metab	2016	26771115	No
1543	5185	1728.3	133.87	44.6	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1544	1728	1728.0	37.4	37.4	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1545	1727	1727.0	61.07	61.1	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1546	8630	1726.0	196.78	39.4	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1547	3452	1726.0	74.18	37.1	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1548	1725	1725.0	56.18	56.2	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1549	1724	1724.0	65.07	65.1	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1550	1723	1723.0	31.2	31.2	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1551	1722	1722.0	58.67	58.7	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1552	3444	1722.0	131.2	65.6	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1553	3444	1722.0	69.52	34.8	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
1554	1722	1722.0	38.71	38.7	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1555	8607	1721.4	324.53	64.9	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1556	5162	1720.7	231.33	77.1	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1557	8602	1720.4	212.46	42.5	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1558	1720	1720.0	37.61	37.6	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1559	1719	1719.0	37.07	37.1	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1560	1718	1718.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1561	3435	1717.5	86.67	43.3	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1562	1717	1717.0	45.53	45.5	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1563	6866	1716.5	225.73	56.4	Common method biases in behavioral research: a critical review of the literature and recommended remedies.	Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff	J Appl Psychol	2003	14516251	No
1564	1716	1716.0	56.56	56.6	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1565	5146	1715.3	161.57	53.9	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1566	1715	1715.0	56.74	56.7	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1567	1714	1714.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H Selye	J Clin Endocrinol Metab	1946	21025115	Yes
1568	5141	1713.7	134.48	44.8	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1569	1712	1712.0	38.61	38.6	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1570	1712	1712.0	41.42	41.4	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1571	1712	1712.0	59.9	59.9	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1572	1712	1712.0	44.57	44.6	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1573	13691	1711.4	396.13	49.5	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
1574	1710	1710.0	33.56	33.6	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1575	3419	1709.5	86.33	43.2	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1576	3418	1709.0	152.31	76.2	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1577	3418	1709.0	82.51	41.3	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1578	1709	1709.0	31.33	31.3	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1579	1709	1709.0	51.31	51.3	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1580	1708	1708.0	32.78	32.8	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1581	6831	1707.8	196.23	49.1	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1582	1707	1707.0	31.38	31.4	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1583	1707	1707.0	68.1	68.1	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1584	17059	1705.9	541.06	54.1	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1585	3410	1705.0	109.88	54.9	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1586	1705	1705.0	52.37	52.4	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1587	1705	1705.0	46.51	46.5	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
1588	3410	1705.0	88.36	44.2	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1589	3409	1704.5	95.94	48.0	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1590	6816	1704.0	143.41	35.9	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1591	5112	1704.0	112.24	37.4	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1592	3407	1703.5	121.95	61.0	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J Karnovsky, L Roots	J Histochem Cytochem	1964	14187330	Yes
1593	1703	1703.0	75.28	75.3	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1594	1703	1703.0	68.58	68.6	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1595	5108	1702.7	120.35	40.1	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1596	3405	1702.5	159.74	79.9	Making sense of Cronbach's alpha.	Mohsen Tavakol, Reg Dennick	Int J Med Educ	2011	28029643	No
1597	3403	1701.5	102.67	51.3	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
1598	3403	1701.5	78.44	39.2	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1599	5100	1700.0	166.93	55.6	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1600	1700	1700.0	38.41	38.4	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1601	5099	1699.7	153.29	51.1	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
1602	1699	1699.0	41.37	41.4	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1603	1699	1699.0	39.66	39.7	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1604	1698	1698.0	42.92	42.9	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1605	1698	1698.0	34.47	34.5	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1606	10186	1697.7	285.06	47.5	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1607	1697	1697.0	69.7	69.7	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1608	1695	1695.0	36.08	36.1	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1609	3389	1694.5	93.69	46.8	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1610	1694	1694.0	38.84	38.8	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1611	1693	1693.0	62.8	62.8	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1612	1693	1693.0	40.03	40.0	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1613	5077	1692.3	182.95	61.0	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
1614	1692	1692.0	36.65	36.6	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1615	3384	1692.0	112.21	56.1	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
1616	3382	1691.0	222.0	111.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1617	1691	1691.0	31.13	31.1	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1618	3382	1691.0	80.94	40.5	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1619	1691	1691.0	68.93	68.9	Macrophage Polarization.	Peter J Murray	Annu Rev Physiol	2017	27813830	No
1620	1690	1690.0	45.29	45.3	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1621	1690	1690.0	51.77	51.8	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1622	6759	1689.8	195.07	48.8	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1623	1689	1689.0	54.7	54.7	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1624	1688	1688.0	40.31	40.3	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1625	1688	1688.0	47.38	47.4	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1626	1688	1688.0	38.83	38.8	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1627	1688	1688.0	36.79	36.8	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1628	1687	1687.0	51.53	51.5	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1629	1686	1686.0	71.28	71.3	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H Mollenhauer	Stain Technol	1964	14127791	Yes
1630	1686	1686.0	53.05	53.0	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1631	1686	1686.0	18.19	18.2	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1632	3372	1686.0	107.68	53.8	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1633	5057	1685.7	109.05	36.4	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1634	3370	1685.0	98.96	49.5	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1635	1685	1685.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S Kety	Pharmacol Rev	1951	14833874	Yes
1636	1684	1684.0	39.13	39.1	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1637	3366	1683.0	135.22	67.6	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
1638	3366	1683.0	83.2	41.6	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1639	6730	1682.5	265.31	66.3	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1640	8410	1682.0	91.41	18.3	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe	JAMA	1963	14044222	Yes
1641	1681	1681.0	44.66	44.7	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1642	1681	1681.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1643	6724	1681.0	223.12	55.8	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1644	3361	1680.5	69.76	34.9	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1645	3361	1680.5	83.4	41.7	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1646	3360	1680.0	125.22	62.6	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1647	3359	1679.5	91.04	45.5	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1648	1679	1679.0	14.08	14.1	Chromatographic Separation Of Human Brain Gangliosides.	L Svennerholm	J Neurochem	1963	14066623	Yes
1649	3357	1678.5	71.42	35.7	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1650	1678	1678.0	60.97	61.0	Modeling Development and Disease with Organoids.	Hans Clevers	Cell	2016	27315476	No
1651	1677	1677.0	49.21	49.2	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1652	1677	1677.0	38.56	38.6	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1653	3353	1676.5	78.55	39.3	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1654	1676	1676.0	58.37	58.4	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1655	1676	1676.0	32.82	32.8	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1656	3352	1676.0	92.32	46.2	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1657	1675	1675.0	31.05	31.1	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1658	3348	1674.0	110.31	55.2	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1659	6695	1673.8	205.25	51.3	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1660	3347	1673.5	79.15	39.6	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1661	1673	1673.0	45.06	45.1	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1662	1673	1673.0	38.37	38.4	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1663	1672	1672.0	81.55	81.5	Hydrogel: Preparation, characterization, and applications: A review.	Enas M Ahmed	J Adv Res	2015	25750745	No
1664	1671	1671.0	59.55	59.5	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1665	1671	1671.0	30.83	30.8	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1666	1671	1671.0	39.62	39.6	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1667	1670	1670.0	50.02	50.0	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1668	10017	1669.5	204.47	34.1	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1669	3339	1669.5	53.82	26.9	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J Marmur, P Doty	J Mol Biol	1962	14470099	Yes
1670	1669	1669.0	46.82	46.8	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1671	1669	1669.0	46.89	46.9	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1672	5006	1668.7	263.45	87.8	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1673	1668	1668.0	53.52	53.5	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1674	5002	1667.3	197.54	65.8	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1675	1667	1667.0	63.88	63.9	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1676	1667	1667.0	19.91	19.9	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1677	1667	1667.0	54.92	54.9	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1678	1667	1667.0	42.64	42.6	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1679	1667	1667.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F Boas	J Biol Chem	1953	13117829	Yes
1680	1667	1667.0	37.14	37.1	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1681	1666	1666.0	82.17	82.2	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1682	1666	1666.0	40.89	40.9	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1683	1666	1666.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G Gray	J Anat	1959	13829103	Yes
1684	1666	1666.0	35.9	35.9	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1685	3330	1665.0	127.29	63.6	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1686	1665	1665.0	32.33	32.3	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1687	1664	1664.0	52.65	52.6	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1688	1664	1664.0	46.06	46.1	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
1689	1663	1663.0	39.7	39.7	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1690	1662	1662.0	39.09	39.1	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1691	1662	1662.0	57.92	57.9	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
1692	11631	1661.6	344.4	49.2	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
1693	1661	1661.0	67.73	67.7	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1694	3322	1661.0	69.12	34.6	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1695	3321	1660.5	215.69	107.8	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1696	1660	1660.0	31.6	31.6	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1697	1660	1660.0	50.44	50.4	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
1698	1658	1658.0	59.49	59.5	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1699	1658	1658.0	46.97	47.0	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1700	1658	1658.0	46.12	46.1	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1701	1657	1657.0	44.42	44.4	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1702	1657	1657.0	35.71	35.7	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1703	1657	1657.0	42.03	42.0	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1704	3313	1656.5	83.61	41.8	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1705	1656	1656.0	31.24	31.2	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1706	1656	1656.0	33.38	33.4	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1707	3312	1656.0	78.11	39.1	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1708	1655	1655.0	23.79	23.8	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1709	3310	1655.0	58.8	29.4	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1710	3309	1654.5	131.57	65.8	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T Omura, R Sato	J Biol Chem	1964	14209972	Yes
1711	3307	1653.5	66.67	33.3	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1712	6612	1653.0	152.47	38.1	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1713	3306	1653.0	137.47	68.7	Parkinson's disease.	Lorraine V Kalia, Anthony E Lang	Lancet	2015	25904081	No
1714	3303	1651.5	66.31	33.2	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1715	1650	1650.0	41.76	41.8	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1716	1650	1650.0	127.1	127.1	User's guide to correlation coefficients.	Haldun Akoglu	Turk J Emerg Med	2018	30191186	No
1717	1648	1648.0	37.56	37.6	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1718	3296	1648.0	75.13	37.6	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1719	1647	1647.0	42.74	42.7	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1720	1646	1646.0	73.45	73.5	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1721	3292	1646.0	83.51	41.8	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
1722	6582	1645.5	287.35	71.8	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1723	3291	1645.5	85.73	42.9	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1724	3291	1645.5	86.52	43.3	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1725	1644	1644.0	46.86	46.9	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1726	1644	1644.0	49.92	49.9	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1727	3287	1643.5	155.33	77.7	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1728	1643	1643.0	54.01	54.0	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1729	1643	1643.0	48.76	48.8	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1730	1643	1643.0	34.84	34.8	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1731	3285	1642.5	71.22	35.6	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1732	1642	1642.0	202.98	203.0	COVID-19 and mental health: A review of the existing literature.	Ravi Philip Rajkumar	Asian J Psychiatr	2020	32302935	Yes
1733	9847	1641.2	227.75	38.0	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1734	1641	1641.0	48.49	48.5	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1735	1641	1641.0	58.0	58.0	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1736	1641	1641.0	45.3	45.3	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1737	1640	1640.0	56.86	56.9	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1738	18037	1639.7	565.31	51.4	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
1739	3279	1639.5	116.89	58.4	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1740	1638	1638.0	72.8	72.8	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1741	3273	1636.5	63.14	31.6	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1742	4908	1636.0	116.4	38.8	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1743	1635	1635.0	56.58	56.6	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1744	1635	1635.0	29.14	29.1	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1745	3267	1633.5	67.96	34.0	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1746	1631	1631.0	40.55	40.5	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D Mattingly	J Clin Pathol	1962	14471419	Yes
1747	1630	1630.0	33.18	33.2	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1748	1630	1630.0	57.2	57.2	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1749	1629	1629.0	71.0	71.0	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1750	1629	1629.0	58.45	58.5	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1751	1629	1629.0	34.69	34.7	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1752	1629	1629.0	40.06	40.1	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1753	4885	1628.3	95.13	31.7	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1754	1628	1628.0	40.79	40.8	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1755	1628	1628.0	53.26	53.3	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
1756	1627	1627.0	42.58	42.6	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1757	1627	1627.0	42.46	42.5	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1758	1626	1626.0	58.06	58.1	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1759	9752	1625.3	338.2	56.4	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1760	1625	1625.0	45.4	45.4	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1761	1624	1624.0	50.86	50.9	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1762	1624	1624.0	22.86	22.9	Structural considerations in the interaction of DNA and acridines.	L S Lerman	J Mol Biol	1961	13761054	Yes
1763	1624	1624.0	66.69	66.7	Structure, Function, and Evolution of Coronavirus Spike Proteins.	Fang Li	Annu Rev Virol	2016	27578435	No
1764	1624	1624.0	76.45	76.5	Neutrophil extracellular traps in immunity and disease.	Venizelos Papayannopoulos	Nat Rev Immunol	2018	28990587	No
1765	1623	1623.0	36.98	37.0	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1766	1622	1622.0	46.51	46.5	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1767	3239	1619.5	89.08	44.5	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1768	1619	1619.0	54.69	54.7	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1769	1619	1619.0	49.12	49.1	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
1770	1619	1619.0	53.0	53.0	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1771	3237	1618.5	76.79	38.4	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1772	1618	1618.0	47.58	47.6	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1773	1618	1618.0	49.44	49.4	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1774	1618	1618.0	30.21	30.2	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1775	3233	1616.5	96.35	48.2	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1776	1616	1616.0	27.54	27.5	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1777	1616	1616.0	30.5	30.5	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1778	1615	1615.0	39.98	40.0	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
1779	1613	1613.0	39.43	39.4	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1780	1612	1612.0	45.62	45.6	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1781	1612	1612.0	33.91	33.9	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1782	1612	1612.0	36.94	36.9	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1783	1611	1611.0	40.53	40.5	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1784	3222	1611.0	172.0	86.0	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
1785	1610	1610.0	52.36	52.4	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1786	1610	1610.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A Lassen	Physiol Rev	1959	13645234	Yes
1787	4830	1610.0	101.82	33.9	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
1788	1609	1609.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1789	1607	1607.0	74.98	75.0	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
1790	3214	1607.0	98.25	49.1	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
1791	3213	1606.5	97.96	49.0	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
1792	1606	1606.0	51.11	51.1	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1793	1606	1606.0	31.56	31.6	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1794	1606	1606.0	37.93	37.9	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
1795	3210	1605.0	94.32	47.2	Unified approach for molecular dynamics and density-functional theory.	R Car, M Parrinello	Phys Rev Lett	1985	10032153	Yes
1796	1605	1605.0	36.66	36.7	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1797	1605	1605.0	30.88	30.9	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1798	3210	1605.0	100.71	50.4	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
1799	3209	1604.5	62.13	31.1	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
1800	1603	1603.0	44.23	44.2	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1801	3206	1603.0	66.24	33.1	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1802	1603	1603.0	45.06	45.1	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1803	1602	1602.0	56.04	56.0	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
1804	3204	1602.0	124.67	62.3	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
1805	3203	1601.5	113.35	56.7	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1806	1601	1601.0	36.84	36.8	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
1807	1601	1601.0	72.58	72.6	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1808	1601	1601.0	39.09	39.1	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1809	1601	1601.0	47.28	47.3	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
1810	3201	1600.5	61.76	30.9	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1811	3200	1600.0	83.26	41.6	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1812	1600	1600.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O Ouchterlony	Acta Pathol Microbiol Scand	1953	13079779	Yes
1813	1599	1599.0	36.21	36.2	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
1814	1599	1599.0	42.22	42.2	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1815	1599	1599.0	36.99	37.0	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1816	1599	1599.0	35.85	35.9	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1817	1598	1598.0	34.41	34.4	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1818	1598	1598.0	30.82	30.8	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
1819	3196	1598.0	71.09	35.5	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1820	3195	1597.5	62.23	31.1	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1821	3195	1597.5	102.88	51.4	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
1822	1597	1597.0	40.86	40.9	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1823	1597	1597.0	45.72	45.7	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1824	1596	1596.0	31.51	31.5	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1825	1596	1596.0	71.26	71.3	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1826	3192	1596.0	67.51	33.8	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1827	3191	1595.5	89.2	44.6	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1828	1595	1595.0	57.28	57.3	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1829	1595	1595.0	28.83	28.8	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1830	1595	1595.0	47.96	48.0	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1831	1595	1595.0	36.8	36.8	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1832	6377	1594.2	216.72	54.2	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
1833	1593	1593.0	39.3	39.3	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
1834	3186	1593.0	77.6	38.8	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1835	3186	1593.0	87.9	44.0	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1836	3185	1592.5	99.82	49.9	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1837	1592	1592.0	35.89	35.9	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1838	3183	1591.5	62.53	31.3	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1839	3183	1591.5	65.21	32.6	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1840	1591	1591.0	48.86	48.9	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1841	3182	1591.0	65.15	32.6	'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?	George Davey Smith, Shah Ebrahim	Int J Epidemiol	2003	12689998	No
1842	3182	1591.0	76.37	38.2	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
1843	1591	1591.0	77.53	77.5	International classification of sleep disorders-third edition: highlights and modifications.	Michael J Sateia	Chest	2014	25367475	No
1844	3181	1590.5	69.04	34.5	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1845	1590	1590.0	40.49	40.5	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
1846	1590	1590.0	63.51	63.5	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
1847	3178	1589.0	91.44	45.7	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1848	1588	1588.0	79.7	79.7	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1849	4764	1588.0	130.33	43.4	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1850	4764	1588.0	115.97	38.7	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1851	1588	1588.0	34.24	34.2	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1852	4762	1587.3	277.05	92.4	SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.	Antoine Daina, Olivier Michielin, Vincent Zoete	Sci Rep	2017	28256516	Yes
1853	1587	1587.0	41.97	42.0	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1854	1587	1587.0	34.42	34.4	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1855	1587	1587.0	35.65	35.6	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
1856	3172	1586.0	92.46	46.2	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1857	1586	1586.0	62.66	62.7	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
1858	1585	1585.0	52.32	52.3	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1859	1585	1585.0	31.11	31.1	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1860	1585	1585.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W Kuffler	J Neurophysiol	1953	13035466	Yes
1861	1584	1584.0	48.15	48.1	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1862	4751	1583.7	115.86	38.6	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1863	1583	1583.0	30.41	30.4	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1864	9495	1582.5	223.68	37.3	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
1865	1582	1582.0	110.4	110.4	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
1866	3164	1582.0	75.12	37.6	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1867	3163	1581.5	96.83	48.4	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
1868	3160	1580.0	58.07	29.0	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1869	1580	1580.0	52.11	52.1	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1870	3159	1579.5	99.26	49.6	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1871	1579	1579.0	29.37	29.4	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1872	1579	1579.0	48.36	48.4	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W Cleland	Biochemistry	1964	14192894	Yes
1873	1578	1578.0	29.75	29.8	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1874	1578	1578.0	29.86	29.9	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1875	1577	1577.0	35.44	35.4	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1876	6301	1575.2	154.53	38.6	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1877	1575	1575.0	52.66	52.7	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
1878	1575	1575.0	42.68	42.7	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1879	1575	1575.0	37.33	37.3	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1880	4725	1575.0	121.79	40.6	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1881	3149	1574.5	68.13	34.1	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1882	1574	1574.0	65.09	65.1	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
1883	1574	1574.0	33.45	33.5	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1884	1574	1574.0	35.89	35.9	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1885	1574	1574.0	37.92	37.9	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
1886	3148	1574.0	67.15	33.6	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1887	1574	1574.0	59.3	59.3	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
1888	1573	1573.0	33.48	33.5	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1889	1572	1572.0	41.65	41.6	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1890	3144	1572.0	70.22	35.1	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1891	1572	1572.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J Rankin	Scott Med J	1957	13432835	Yes
1892	1572	1572.0	29.82	29.8	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1893	3144	1572.0	67.17	33.6	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1894	3143	1571.5	93.28	46.6	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
1895	3143	1571.5	140.17	70.1	MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.	Rajesha Rupaimoole, Frank J Slack	Nat Rev Drug Discov	2017	28209991	No
1896	3141	1570.5	116.94	58.5	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
1897	1570	1570.0	44.78	44.8	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
1898	1570	1570.0	37.66	37.7	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1899	1570	1570.0	26.04	26.0	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1900	3139	1569.5	109.77	54.9	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
1901	1569	1569.0	59.4	59.4	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1902	9414	1569.0	265.92	44.3	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
1903	3137	1568.5	101.12	50.6	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
1904	3136	1568.0	60.45	30.2	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1905	1568	1568.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C Hummel	Can J Biochem Physiol	1959	14405350	Yes
1906	1567	1567.0	27.69	27.7	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1907	3134	1567.0	73.97	37.0	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1908	3133	1566.5	66.24	33.1	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
1909	1566	1566.0	31.18	31.2	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1910	3131	1565.5	75.79	37.9	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1911	3131	1565.5	90.89	45.4	Extended-connectivity fingerprints.	David Rogers, Mathew Hahn	J Chem Inf Model	2010	20426451	Yes
1912	4695	1565.0	87.53	29.2	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1913	3130	1565.0	79.21	39.6	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1914	4686	1562.0	92.83	30.9	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1915	1562	1562.0	45.97	46.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
1916	1562	1562.0	48.33	48.3	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
1917	3121	1560.5	66.63	33.3	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1918	1560	1560.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
1919	4679	1559.7	104.71	34.9	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M G Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1920	1559	1559.0	77.79	77.8	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
1921	1559	1559.0	36.43	36.4	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1922	3114	1557.0	58.5	29.2	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1923	1557	1557.0	38.34	38.3	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1924	15569	1556.9	370.54	37.1	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1925	3113	1556.5	94.64	47.3	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
1926	1555	1555.0	61.21	61.2	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1927	1555	1555.0	31.22	31.2	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1928	1555	1555.0	41.97	42.0	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
1929	1555	1555.0	33.48	33.5	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
1930	3108	1554.0	81.55	40.8	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
1931	10878	1554.0	302.37	43.2	BLAST+: architecture and applications.	Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden	BMC Bioinformatics	2009	20003500	Yes
1932	1553	1553.0	35.13	35.1	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1933	3106	1553.0	88.26	44.1	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
1934	4658	1552.7	103.47	34.5	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
1935	4658	1552.7	122.71	40.9	Fast model-based estimation of ancestry in unrelated individuals.	David H Alexander, John Novembre, Kenneth Lange	Genome Res	2009	19648217	Yes
1936	3105	1552.5	106.59	53.3	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
1937	3105	1552.5	116.24	58.1	Elements of cancer immunity and the cancer-immune set point.	Daniel S Chen, Ira Mellman	Nature	2017	28102259	No
1938	1552	1552.0	36.2	36.2	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
1939	3104	1552.0	61.99	31.0	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1940	1552	1552.0	42.72	42.7	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
1941	4653	1551.0	155.93	52.0	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1942	1551	1551.0	37.07	37.1	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1943	4652	1550.7	128.41	42.8	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1944	1550	1550.0	48.21	48.2	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1945	3098	1549.0	40.02	20.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1946	1549	1549.0	32.3	32.3	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1947	4647	1549.0	702.75	234.2	MEGA11: Molecular Evolutionary Genetics Analysis Version 11.	Koichiro Tamura, Glen Stecher, Sudhir Kumar	Mol Biol Evol	2021	33892491	Yes
1948	4643	1547.7	88.51	29.5	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
1949	1547	1547.0	43.75	43.8	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
1950	1546	1546.0	42.11	42.1	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1951	3091	1545.5	71.27	35.6	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1952	3090	1545.0	182.39	91.2	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1953	1545	1545.0	48.67	48.7	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1954	3090	1545.0	62.99	31.5	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1955	3090	1545.0	79.89	39.9	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
1956	1544	1544.0	43.48	43.5	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1957	3086	1543.0	79.36	39.7	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1958	3086	1543.0	56.71	28.4	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1959	7710	1542.0	152.35	30.5	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1960	1542	1542.0	28.59	28.6	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1961	1542	1542.0	51.15	51.1	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1962	1541	1541.0	30.86	30.9	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1963	3082	1541.0	68.63	34.3	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
1964	3081	1540.5	63.53	31.8	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1965	3081	1540.5	62.0	31.0	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1966	18482	1540.2	757.59	63.1	Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.	Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm	Genet Med	2015	25741868	No
1967	1540	1540.0	51.35	51.4	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
1968	3079	1539.5	183.58	91.8	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1969	3077	1538.5	76.62	38.3	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1970	1538	1538.0	55.35	55.4	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
1971	1538	1538.0	30.28	30.3	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
1972	1538	1538.0	29.93	29.9	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1973	6152	1538.0	120.01	30.0	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1974	1538	1538.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H Eagle	Science	1955	13255879	Yes
1975	1538	1538.0	41.89	41.9	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1976	1538	1538.0	45.44	45.4	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
1977	4613	1537.7	117.54	39.2	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
1978	3075	1537.5	71.47	35.7	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1979	3074	1537.0	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G Schmidt, S J Thannhauser	J Biol Chem	1945	21005717	Yes
1980	1536	1536.0	59.72	59.7	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
1981	1536	1536.0	43.82	43.8	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
1982	3072	1536.0	128.11	64.1	Sex differences in immune responses.	Sabra L Klein, Katie L Flanagan	Nat Rev Immunol	2016	27546235	No
1983	3071	1535.5	68.09	34.0	ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking.	Matthew D Wilkerson, D Neil Hayes	Bioinformatics	2010	20427518	Yes
1984	4606	1535.3	99.7	33.2	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
1985	3070	1535.0	103.87	51.9	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
1986	1534	1534.0	43.47	43.5	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1987	3068	1534.0	21.53	10.8	Junctional complexes in various epithelia.	M G Farquhar, G E Palade	J Cell Biol	1963	13944428	Yes
1988	1534	1534.0	58.85	58.9	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
1989	1533	1533.0	35.81	35.8	Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults.	Bei-Fan Zhou	Biomed Environ Sci	2002	12046553	Yes
1990	3065	1532.5	67.58	33.8	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1991	1532	1532.0	48.76	48.8	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1992	1531	1531.0	56.27	56.3	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1993	1531	1531.0	42.57	42.6	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1994	1531	1531.0	45.82	45.8	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
1995	3061	1530.5	67.72	33.9	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1996	13773	1530.3	424.12	47.1	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
1997	4588	1529.3	129.44	43.1	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1998	9175	1529.2	282.94	47.2	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
1999	1529	1529.0	66.59	66.6	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2000	1528	1528.0	41.29	41.3	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
2001	1528	1528.0	22.23	22.2	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
2002	1528	1528.0	31.37	31.4	Antigen-Antibody Crossed Electrophoresis.	C B Laurell	Anal Biochem	1965	14302464	Yes
2003	3055	1527.5	79.23	39.6	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
2004	3055	1527.5	93.86	46.9	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
2005	1527	1527.0	33.72	33.7	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
2006	1526	1526.0	37.95	38.0	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
2007	1526	1526.0	33.74	33.7	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
2008	3051	1525.5	71.07	35.5	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
2009	1525	1525.0	38.85	38.9	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
2010	1525	1525.0	34.6	34.6	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
2011	3048	1524.0	87.51	43.8	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
2012	4572	1524.0	229.95	76.6	Radiomics: Images Are More than Pictures, They Are Data.	Robert J Gillies, Paul E Kinahan, Hedvig Hricak	Radiology	2016	26579733	Yes
2013	3047	1523.5	119.08	59.5	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
2014	3047	1523.5	80.07	40.0	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
2015	1523	1523.0	50.54	50.5	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
2016	1523	1523.0	46.12	46.1	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
2017	1523	1523.0	34.59	34.6	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
2018	1522	1522.0	45.52	45.5	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
2019	4563	1521.0	111.03	37.0	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2020	1520	1520.0	18.65	18.6	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
2021	4560	1520.0	117.7	39.2	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
2022	1520	1520.0	42.18	42.2	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2023	1520	1520.0	32.6	32.6	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
2024	9119	1519.8	213.74	35.6	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2025	4559	1519.7	96.42	32.1	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
2026	1519	1519.0	90.98	91.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
2027	3038	1519.0	102.24	51.1	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
2028	1519	1519.0	49.24	49.2	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2029	1519	1519.0	31.79	31.8	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
2030	16709	1519.0	437.2	39.7	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
2031	3035	1517.5	148.47	74.2	A simple practice guide for dose conversion between animals and human.	Anroop B Nair, Shery Jacob	J Basic Clin Pharm	2016	27057123	No
2032	1517	1517.0	55.75	55.8	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
2033	1517	1517.0	28.03	28.0	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
2034	3033	1516.5	65.81	32.9	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
2035	1515	1515.0	37.95	38.0	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
2036	1515	1515.0	37.38	37.4	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
2037	1514	1514.0	40.19	40.2	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
2038	1513	1513.0	50.23	50.2	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
2039	1512	1512.0	66.55	66.5	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2040	1511	1511.0	50.0	50.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2041	1511	1511.0	46.99	47.0	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2042	1511	1511.0	38.08	38.1	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
2043	3022	1511.0	82.62	41.3	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2044	4531	1510.3	156.98	52.3	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
2045	1510	1510.0	32.94	32.9	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
2046	1508	1508.0	33.09	33.1	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2047	1507	1507.0	48.12	48.1	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
2048	1507	1507.0	33.63	33.6	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
2049	4520	1506.7	120.51	40.2	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2050	1506	1506.0	48.32	48.3	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2051	3008	1504.0	71.93	36.0	Decision curve analysis: a novel method for evaluating prediction models.	Andrew J Vickers, Elena B Elkin	Med Decis Making	2006	17099194	Yes
2052	3007	1503.5	58.94	29.5	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
2053	1503	1503.0	48.32	48.3	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2054	3005	1502.5	89.97	45.0	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
2055	3005	1502.5	88.86	44.4	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
2056	4507	1502.3	162.13	54.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
2057	19522	1501.7	505.85	38.9	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2058	1501	1501.0	40.73	40.7	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
2059	1501	1501.0	42.32	42.3	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
2060	4500	1500.0	50.84	16.9	Improved method for the determination of blood glutathione.	E Beutler, O Duron, B M Kelly	J Lab Clin Med	1963	13967893	Yes
2061	1499	1499.0	25.39	25.4	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K Fuxe	Acta Physiol Scand Suppl	1965	14319769	Yes
2062	2997	1498.5	66.33	33.2	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
2063	1498	1498.0	35.57	35.6	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
2064	1498	1498.0	32.79	32.8	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2065	1498	1498.0	39.14	39.1	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2066	2996	1498.0	76.26	38.1	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
2067	2996	1498.0	73.57	36.8	Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.	Felix Krueger, Simon R Andrews	Bioinformatics	2011	21493656	Yes
2068	4494	1498.0	162.97	54.3	Complex heatmaps reveal patterns and correlations in multidimensional genomic data.	Zuguang Gu, Roland Eils, Matthias Schlesner	Bioinformatics	2016	27207943	Yes
2069	1497	1497.0	51.86	51.9	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
2070	1497	1497.0	42.41	42.4	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
2071	2994	1497.0	0.0	0.0	Lactic dehydrogenase activity in blood.	F Wroblewski, J S Ladue	Proc Soc Exp Biol Med	1955	13273400	Yes
2072	1497	1497.0	63.39	63.4	Periodontitis: from microbial immune subversion to systemic inflammation.	George Hajishengallis	Nat Rev Immunol	2015	25534621	No
2073	2993	1496.5	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
2074	2993	1496.5	61.72	30.9	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2075	1496	1496.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
2076	2992	1496.0	87.47	43.7	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
2077	1495	1495.0	47.73	47.7	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
2078	1495	1495.0	50.91	50.9	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2079	1495	1495.0	57.68	57.7	AliView: a fast and lightweight alignment viewer and editor for large datasets.	Anders Larsson	Bioinformatics	2014	25095880	Yes
2080	2989	1494.5	87.05	43.5	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2081	10461	1494.4	222.95	31.8	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
2082	1494	1494.0	26.32	26.3	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
2083	1494	1494.0	33.57	33.6	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
2084	2987	1493.5	112.26	56.1	Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.	Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon	Brain Connect	2012	22642651	Yes
2085	1493	1493.0	33.15	33.1	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
2086	1493	1493.0	46.54	46.5	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
2087	1493	1493.0	71.85	71.8	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
2088	1493	1493.0	37.01	37.0	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
2089	2985	1492.5	59.92	30.0	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
2090	2985	1492.5	64.16	32.1	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2091	2982	1491.0	99.41	49.7	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2092	1491	1491.0	31.38	31.4	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2093	1491	1491.0	31.83	31.8	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2094	2981	1490.5	57.03	28.5	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
2095	1490	1490.0	26.08	26.1	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
2096	1490	1490.0	36.43	36.4	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2097	1488	1488.0	43.29	43.3	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2098	1488	1488.0	43.1	43.1	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
2099	1487	1487.0	34.07	34.1	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
2100	1486	1486.0	39.11	39.1	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
2101	1486	1486.0	27.43	27.4	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
2102	1484	1484.0	19.77	19.8	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
2103	5934	1483.5	129.5	32.4	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
2104	1483	1483.0	33.19	33.2	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
2105	8893	1482.2	261.85	43.6	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke	Lancet	2007	18064739	Yes
2106	1482	1482.0	18.46	18.5	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
2107	1482	1482.0	36.89	36.9	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2108	4445	1481.7	79.23	26.4	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A Winter, E A Risley, G W Nuss	Proc Soc Exp Biol Med	1962	14001233	Yes
2109	4444	1481.3	93.55	31.2	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
2110	4440	1480.0	45.72	15.2	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T Dodge, C Mitchell, D J Hanahan	Arch Biochem Biophys	1963	14028302	Yes
2111	1479	1479.0	45.56	45.6	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2112	1479	1479.0	30.56	30.6	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
2113	1479	1479.0	54.82	54.8	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2114	5914	1478.5	247.34	61.8	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
2115	8869	1478.2	259.6	43.3	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
2116	1478	1478.0	43.18	43.2	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2117	1478	1478.0	58.55	58.5	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2118	1478	1478.0	39.44	39.4	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
2119	1478	1478.0	7.9	7.9	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W Sperry	Proc Natl Acad Sci U S A	1963	14077501	Yes
2120	4433	1477.7	111.11	37.0	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2121	1477	1477.0	37.15	37.1	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
2122	1477	1477.0	40.15	40.1	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
2123	2954	1477.0	87.01	43.5	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2124	1477	1477.0	0.0	0.0	A new readability yardstick.	R Flesch	J Appl Psychol	1948	18867058	Yes
2125	1477	1477.0	59.33	59.3	The global burden of IBD: from 2015 to 2025.	Gilaad G Kaplan	Nat Rev Gastroenterol Hepatol	2015	26323879	No
2126	13286	1476.2	625.32	69.5	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2127	1475	1475.0	46.07	46.1	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
2128	1475	1475.0	33.77	33.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2129	1475	1475.0	76.24	76.2	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2130	1473	1473.0	10.66	10.7	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E Huxley	J Mol Biol	1963	14064165	Yes
2131	1473	1473.0	59.61	59.6	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
2132	2945	1472.5	114.02	57.0	Cisplatin in cancer therapy: molecular mechanisms of action.	Shaloam Dasari, Paul Bernard Tchounwou	Eur J Pharmacol	2014	25058905	No
2133	2944	1472.0	81.19	40.6	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
2134	2944	1472.0	76.53	38.3	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
2135	1472	1472.0	34.08	34.1	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C Nowell	Cancer Res	1960	14427849	Yes
2136	1472	1472.0	40.24	40.2	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
2137	2944	1472.0	74.35	37.2	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2138	1470	1470.0	36.37	36.4	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
2139	1470	1470.0	30.2	30.2	The Relation Of Recombination To Mutational Advance.	H J Muller	Mutat Res	1964	14195748	Yes
2140	13225	1469.4	408.26	45.4	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
2141	2938	1469.0	199.47	99.7	ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R.	Emmanuel Paradis, Klaus Schliep	Bioinformatics	2019	30016406	Yes
2142	4406	1468.7	133.63	44.5	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2143	2936	1468.0	91.74	45.9	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
2144	2936	1468.0	107.9	54.0	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2145	4398	1466.0	95.6	31.9	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
2146	1466	1466.0	39.41	39.4	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
2147	1466	1466.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B Mountcastle	J Neurophysiol	1957	13439410	Yes
2148	1466	1466.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
2149	4398	1466.0	219.37	73.1	Shedding light on the cell biology of extracellular vesicles.	Guillaume van Niel, Gisela D'Angelo, Graça Raposo	Nat Rev Mol Cell Biol	2018	29339798	No
2150	1465	1465.0	33.51	33.5	Simple methods for "staining with lead" at high pH in electron microscopy.	M J Karnovsky	J Biophys Biochem Cytol	1961	14454024	Yes
2151	2929	1464.5	41.44	20.7	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G Gray, V P Whittaker	J Anat	1962	13901297	Yes
2152	1464	1464.0	42.81	42.8	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2153	1463	1463.0	33.83	33.8	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
2154	1463	1463.0	50.86	50.9	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
2155	2925	1462.5	88.74	44.4	CTFFIND4: Fast and accurate defocus estimation from electron micrographs.	Alexis Rohou, Nikolaus Grigorieff	J Struct Biol	2015	26278980	Yes
2156	4387	1462.3	126.57	42.2	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallières, C M. Morin	Sleep Med	2001	11438246	Yes
2157	1462	1462.0	19.54	19.5	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2158	1462	1462.0	34.29	34.3	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
2159	1462	1462.0	40.95	41.0	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2160	2924	1462.0	77.71	38.9	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
2161	1462	1462.0	31.81	31.8	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2162	1461	1461.0	38.18	38.2	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2163	4381	1460.3	85.66	28.6	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2164	1460	1460.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E Bush	Biochem J	1952	14915960	Yes
2165	1460	1460.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
2166	1460	1460.0	31.8	31.8	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2167	1460	1460.0	41.83	41.8	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2168	2919	1459.5	67.66	33.8	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2169	1459	1459.0	43.85	43.9	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2170	1459	1459.0	32.97	33.0	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2171	1458	1458.0	56.92	56.9	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2172	2916	1458.0	98.38	49.2	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
2173	1458	1458.0	94.15	94.2	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2174	1458	1458.0	36.44	36.4	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
2175	2915	1457.5	73.62	36.8	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
2176	1457	1457.0	34.36	34.4	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
2177	1457	1457.0	33.37	33.4	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
2178	2913	1456.5	57.85	28.9	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2179	1456	1456.0	35.61	35.6	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2180	1456	1456.0	64.85	64.8	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
2181	2911	1455.5	119.52	59.8	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
2182	1455	1455.0	36.89	36.9	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2183	1455	1455.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H Rosen	Arch Biochem Biophys	1957	13412116	Yes
2184	1454	1454.0	50.95	51.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2185	2906	1453.0	103.55	51.8	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
2186	1453	1453.0	46.18	46.2	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
2187	1453	1453.0	29.67	29.7	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
2188	11619	1452.4	288.91	36.1	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2189	1452	1452.0	28.89	28.9	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
2190	1452	1452.0	31.52	31.5	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
2191	2904	1452.0	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H Clarke, J Casals	Am J Trop Med Hyg	1958	13571577	Yes
2192	2903	1451.5	74.59	37.3	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
2193	2903	1451.5	73.42	36.7	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2194	4354	1451.3	101.28	33.8	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2195	1451	1451.0	34.7	34.7	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2196	2901	1450.5	93.13	46.6	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
2197	5801	1450.2	211.76	52.9	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
2198	1450	1450.0	57.62	57.6	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2199	2899	1449.5	79.37	39.7	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
2200	1449	1449.0	35.52	35.5	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2201	1449	1449.0	40.15	40.1	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2202	2896	1448.0	75.35	37.7	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
2203	1448	1448.0	48.58	48.6	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
2204	4343	1447.7	92.59	30.9	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
2205	2895	1447.5	94.75	47.4	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
2206	5790	1447.5	162.51	40.6	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
2207	5789	1447.2	146.9	36.7	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2208	1447	1447.0	33.57	33.6	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
2209	2894	1447.0	66.06	33.0	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
2210	1446	1446.0	30.29	30.3	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
2211	2892	1446.0	62.04	31.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H Anton, D F Sayre	J Pharmacol Exp Ther	1962	14013351	Yes
2212	1445	1445.0	35.86	35.9	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2213	2890	1445.0	60.21	30.1	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2214	1443	1443.0	37.88	37.9	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2215	1443	1443.0	36.71	36.7	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2216	2885	1442.5	86.06	43.0	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2217	1442	1442.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
2218	1442	1442.0	40.7	40.7	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2219	2883	1441.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D Davis, E S Mingioli	J Bacteriol	1950	15436457	Yes
2220	1441	1441.0	42.29	42.3	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
2221	2881	1440.5	78.36	39.2	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2222	1440	1440.0	48.12	48.1	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2223	1440	1440.0	49.8	49.8	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
2224	1439	1439.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D Poulik	Nature	1957	13493570	Yes
2225	1439	1439.0	44.94	44.9	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
2226	2877	1438.5	57.25	28.6	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2227	2877	1438.5	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
2228	2875	1437.5	67.42	33.7	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
2229	2875	1437.5	86.62	43.3	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2230	5749	1437.2	168.0	42.0	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2231	1437	1437.0	94.31	94.3	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
2232	1437	1437.0	36.5	36.5	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2233	1437	1437.0	42.82	42.8	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2234	2872	1436.0	55.31	27.7	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2235	2872	1436.0	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J Bloom, W W Richardson	Br J Cancer	1957	13499785	Yes
2236	1436	1436.0	62.27	62.3	Machine Learning in Medicine.	Rahul C Deo	Circulation	2015	26572668	No
2237	1435	1435.0	37.0	37.0	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
2238	1435	1435.0	43.75	43.8	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2239	1435	1435.0	21.44	21.4	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2240	1435	1435.0	53.8	53.8	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2241	1434	1434.0	49.93	49.9	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2242	2867	1433.5	73.18	36.6	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2243	1433	1433.0	42.57	42.6	Strong localization of photons in certain disordered dielectric superlattices.	S John	Phys Rev Lett	1987	10034761	Yes
2244	2864	1432.0	53.75	26.9	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2245	7155	1431.0	154.09	30.8	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
2246	1431	1431.0	60.4	60.4	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2247	1431	1431.0	33.77	33.8	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2248	2860	1430.0	97.94	49.0	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2249	2859	1429.5	100.45	50.2	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2250	4288	1429.3	86.48	28.8	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2251	4285	1428.3	122.18	40.7	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2252	1428	1428.0	43.24	43.2	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2253	1428	1428.0	37.32	37.3	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2254	1428	1428.0	27.29	27.3	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2255	1428	1428.0	51.05	51.0	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2256	2854	1427.0	70.18	35.1	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
2257	1427	1427.0	41.05	41.0	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2258	4281	1427.0	88.05	29.3	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
2259	1427	1427.0	40.67	40.7	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2260	5707	1426.8	156.14	39.0	Image quality assessment: from error visibility to structural similarity.	Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli	IEEE Trans Image Process	2004	15376593	Yes
2261	1426	1426.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P Moran	Biometrika	1950	15420245	Yes
2262	1426	1426.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L Welch	Biometrika	1947	20287819	Yes
2263	5703	1425.8	258.53	64.6	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2264	1424	1424.0	39.92	39.9	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2265	1424	1424.0	40.75	40.8	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
2266	1424	1424.0	33.78	33.8	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2267	1424	1424.0	44.29	44.3	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2268	2847	1423.5	54.98	27.5	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2269	1423	1423.0	25.65	25.6	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2270	1422	1422.0	26.63	26.6	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
2271	1421	1421.0	33.34	33.3	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
2272	1421	1421.0	40.85	40.9	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J Wyman	Adv Protein Chem	1964	14268785	No
2273	1421	1421.0	39.93	39.9	BEDTools: The Swiss-Army Tool for Genome Feature Analysis.	Aaron R Quinlan	Curr Protoc Bioinformatics	2014	25199790	Yes
2274	1420	1420.0	51.48	51.5	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
2275	1420	1420.0	39.24	39.2	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2276	2838	1419.0	79.31	39.7	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2277	2837	1418.5	81.73	40.9	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2278	1418	1418.0	24.55	24.6	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2279	1418	1418.0	37.64	37.6	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2280	2835	1417.5	54.92	27.5	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2281	1417	1417.0	35.78	35.8	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2282	1417	1417.0	44.37	44.4	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2283	8497	1416.2	278.51	46.4	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
2284	2832	1416.0	89.88	44.9	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2285	2831	1415.5	82.4	41.2	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
2286	4245	1415.0	139.96	46.7	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2287	2830	1415.0	83.83	41.9	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2288	1414	1414.0	33.66	33.7	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2289	4241	1413.7	144.53	48.2	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2290	8478	1413.0	217.02	36.2	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2291	2825	1412.5	88.56	44.3	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
2292	4237	1412.3	147.99	49.3	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2293	1412	1412.0	50.87	50.9	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2294	2824	1412.0	52.41	26.2	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2295	1412	1412.0	66.27	66.3	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L Ramanathan	J Appl Physiol	1964	14173555	Yes
2296	2823	1411.5	86.22	43.1	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2297	1411	1411.0	35.47	35.5	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2298	1410	1410.0	34.63	34.6	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2299	4228	1409.3	101.08	33.7	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2300	1409	1409.0	45.96	46.0	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
2301	2818	1409.0	0.0	0.0	Virus interference. I. The interferon.	A Isaacs, J Lindenmann	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2302	1408	1408.0	63.22	63.2	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2303	2816	1408.0	72.39	36.2	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
2304	2815	1407.5	89.27	44.6	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2305	2815	1407.5	62.3	31.1	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2306	4221	1407.0	93.74	31.2	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2307	2813	1406.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L Hodgkin, B Katz	J Physiol	1949	18128147	Yes
2308	1406	1406.0	64.61	64.6	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
2309	2811	1405.5	81.38	40.7	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2310	2811	1405.5	69.69	34.8	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2311	2809	1404.5	76.97	38.5	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2312	1404	1404.0	32.78	32.8	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2313	1404	1404.0	25.32	25.3	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
2314	2806	1403.0	147.64	73.8	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2315	2806	1403.0	70.94	35.5	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2316	1403	1403.0	33.36	33.4	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2317	2805	1402.5	69.9	35.0	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2318	1402	1402.0	26.15	26.1	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
2319	1402	1402.0	36.29	36.3	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2320	1402	1402.0	63.06	63.1	Oxidative stress: a concept in redox biology and medicine.	Helmut Sies	Redox Biol	2015	25588755	No
2321	2803	1401.5	62.39	31.2	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2322	2800	1400.0	42.02	21.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2323	1400	1400.0	40.55	40.5	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2324	1400	1400.0	34.85	34.9	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2325	1399	1399.0	30.67	30.7	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2326	4195	1398.3	106.47	35.5	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2327	1398	1398.0	31.56	31.6	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
2328	1397	1397.0	29.05	29.1	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2329	2794	1397.0	99.55	49.8	Role of the microbiota in immunity and inflammation.	Yasmine Belkaid, Timothy W Hand	Cell	2014	24679531	No
2330	2792	1396.0	82.4	41.2	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2331	1396	1396.0	31.94	31.9	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2332	1396	1396.0	33.91	33.9	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2333	1396	1396.0	30.28	30.3	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2334	2792	1396.0	68.79	34.4	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2335	2791	1395.5	69.29	34.6	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2336	4186	1395.3	196.52	65.5	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2337	1395	1395.0	17.41	17.4	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2338	2790	1395.0	61.42	30.7	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
2339	1395	1395.0	44.13	44.1	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2340	2790	1395.0	83.46	41.7	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2341	1395	1395.0	29.61	29.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2342	1394	1394.0	50.12	50.1	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2343	2788	1394.0	81.87	40.9	Microdetermination of long-chain fatty acids in plasma and tissues.	V P Dole, H Meinertz	J Biol Chem	1960	13817286	Yes
2344	2787	1393.5	65.79	32.9	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2345	1393	1393.0	52.88	52.9	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2346	1393	1393.0	29.48	29.5	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2347	6963	1392.6	257.08	51.4	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2348	1392	1392.0	33.23	33.2	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2349	2783	1391.5	67.36	33.7	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2350	4174	1391.3	87.8	29.3	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2351	1391	1391.0	26.94	26.9	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2352	1391	1391.0	24.46	24.5	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2353	4168	1389.3	111.42	37.1	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2354	2778	1389.0	74.34	37.2	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2355	4166	1388.7	83.9	28.0	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2356	2776	1388.0	108.38	54.2	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2357	4163	1387.7	135.51	45.2	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2358	1387	1387.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E Satterthwaite	Biometrics	1946	20287815	Yes
2359	5547	1386.8	210.2	52.5	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2360	1386	1386.0	35.45	35.5	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2361	1386	1386.0	43.85	43.9	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2362	1386	1386.0	44.26	44.3	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2363	2771	1385.5	94.87	47.4	A new scale of social desirability independent of psychopathology.	D P Crowne, D Marlowe	J Consult Psychol	1960	13813058	Yes
2364	2770	1385.0	71.58	35.8	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
2365	1385	1385.0	129.26	129.3	A Review of Coronavirus Disease-2019 (COVID-19).	Tanu Singhal	Indian J Pediatr	2020	32166607	No
2366	4154	1384.7	98.89	33.0	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2367	2769	1384.5	80.11	40.1	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2368	1384	1384.0	50.48	50.5	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2369	2768	1384.0	100.71	50.4	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2370	1384	1384.0	32.02	32.0	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2371	1383	1383.0	30.71	30.7	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2372	2766	1383.0	61.38	30.7	Immunoassay of endogenous plasma insulin in man.	R S Yalow, S A Berson	J Clin Invest	1960	13846364	Yes
2373	6914	1382.8	200.27	40.1	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2374	2765	1382.5	54.86	27.4	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2375	1382	1382.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C Schneider	J Biol Chem	1948	18886166	Yes
2376	2763	1381.5	63.14	31.6	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
2377	1380	1380.0	33.81	33.8	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2378	1379	1379.0	51.9	51.9	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2379	6890	1378.0	260.81	52.2	Fsl.	Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith	Neuroimage	2012	21979382	No
2380	1377	1377.0	42.94	42.9	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2381	1377	1377.0	32.29	32.3	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2382	2753	1376.5	94.43	47.2	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2383	6881	1376.2	308.1	61.6	BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.	Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov	Bioinformatics	2015	26059717	Yes
2384	1376	1376.0	59.69	59.7	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2385	1376	1376.0	39.23	39.2	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2386	1376	1376.0	30.96	31.0	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2387	2751	1375.5	70.44	35.2	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2388	2750	1375.0	80.09	40.0	Software survey: VOSviewer, a computer program for bibliometric mapping.	Nees Jan van Eck, Ludo Waltman	Scientometrics	2010	20585380	Yes
2389	2748	1374.0	63.38	31.7	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2390	1374	1374.0	37.52	37.5	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
2391	1374	1374.0	32.06	32.1	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2392	1373	1373.0	25.95	25.9	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2393	2745	1372.5	73.52	36.8	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2394	2744	1372.0	58.01	29.0	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2395	2743	1371.5	77.35	38.7	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2396	6857	1371.4	166.97	33.4	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2397	1371	1371.0	21.49	21.5	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
2398	1371	1371.0	22.36	22.4	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2399	2741	1370.5	87.39	43.7	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A Dahlstroem, K Fuxe	Acta Physiol Scand Suppl	1964	14229500	Yes
2400	2741	1370.5	88.52	44.3	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2401	1370	1370.0	28.39	28.4	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2402	2740	1370.0	68.2	34.1	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2403	2740	1370.0	65.49	32.7	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2404	1370	1370.0	48.23	48.2	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
2405	2739	1369.5	55.34	27.7	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
2406	4108	1369.3	91.52	30.5	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2407	1369	1369.0	36.24	36.2	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2408	2737	1368.5	89.16	44.6	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2409	1368	1368.0	30.24	30.2	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2410	2735	1367.5	76.56	38.3	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2411	4102	1367.3	119.73	39.9	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2412	1367	1367.0	58.02	58.0	1,500 scientists lift the lid on reproducibility.	Monya Baker	Nature	2016	27225100	No
2413	1366	1366.0	31.31	31.3	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2414	1366	1366.0	0.0	0.0	The critical incident technique.	J C Flanagan	Psychol Bull	1954	13177800	Yes
2415	1366	1366.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O Smithies	Biochem J	1959	13638269	Yes
2416	1366	1366.0	27.97	28.0	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2417	1366	1366.0	56.4	56.4	Transcriptional architecture of the mammalian circadian clock.	Joseph S Takahashi	Nat Rev Genet	2017	27990019	No
2418	8193	1365.5	205.31	34.2	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2419	2731	1365.5	66.64	33.3	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2420	1365	1365.0	46.88	46.9	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2421	1365	1365.0	29.72	29.7	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2422	2727	1363.5	66.56	33.3	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2423	1363	1363.0	36.24	36.2	Sarcopenia: origins and clinical relevance.	I H Rosenberg	J Nutr	1997	9164280	No
2424	2726	1363.0	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B Chance, G R Williams	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
2425	5452	1363.0	135.76	33.9	Universal sample preparation method for proteome analysis.	Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2426	1363	1363.0	52.73	52.7	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
2427	2726	1363.0	74.07	37.0	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2428	9540	1362.9	386.38	55.2	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2429	1362	1362.0	29.94	29.9	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2430	1362	1362.0	24.22	24.2	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2431	1362	1362.0	36.4	36.4	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2432	4085	1361.7	116.61	38.9	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2433	2723	1361.5	52.12	26.1	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
2434	2723	1361.5	96.11	48.1	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2435	2723	1361.5	56.26	28.1	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
2436	2723	1361.5	59.23	29.6	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2437	4083	1361.0	148.74	49.6	Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.	C J Caspersen, K E Powell, G M Christenson	Public Health Rep	1985	3920711	Yes
2438	1361	1361.0	46.37	46.4	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
2439	4083	1361.0	99.41	33.1	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2440	2721	1360.5	80.23	40.1	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2441	2720	1360.0	79.76	39.9	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2442	1360	1360.0	40.55	40.5	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2443	1359	1359.0	32.66	32.7	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
2444	1359	1359.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B Caulfield	J Biophys Biochem Cytol	1957	13475399	Yes
2445	1358	1358.0	43.53	43.5	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2446	1358	1358.0	24.63	24.6	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2447	2716	1358.0	76.11	38.1	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2448	2715	1357.5	61.4	30.7	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2449	2715	1357.5	108.98	54.5	A typology of reviews: an analysis of 14 review types and associated methodologies.	Maria J Grant, Andrew Booth	Health Info Libr J	2009	19490148	No
2450	1357	1357.0	42.95	43.0	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2451	2712	1356.0	131.11	65.6	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2452	1356	1356.0	42.39	42.4	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2453	2711	1355.5	90.01	45.0	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
2454	2711	1355.5	55.17	27.6	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2455	1355	1355.0	64.7	64.7	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
2456	1355	1355.0	37.78	37.8	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2457	2708	1354.0	70.83	35.4	Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis).	S M Rogers, L Bernatchez	Mol Ecol	2005	15660930	Yes
2458	2708	1354.0	83.44	41.7	Molecular and cellular insights into T cell exhaustion.	E John Wherry, Makoto Kurachi	Nat Rev Immunol	2015	26205583	No
2459	1353	1353.0	28.96	29.0	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2460	1353	1353.0	52.12	52.1	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
2461	1353	1353.0	56.37	56.4	Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.	Karimollah Hajian-Tilaki	Caspian J Intern Med	2013	24009950	No
2462	2704	1352.0	62.43	31.2	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
2463	1352	1352.0	29.58	29.6	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2464	2704	1352.0	179.78	89.9	OrthoFinder: phylogenetic orthology inference for comparative genomics.	David M Emms, Steven Kelly	Genome Biol	2019	31727128	Yes
2465	1351	1351.0	28.71	28.7	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2466	1351	1351.0	27.54	27.5	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2467	5404	1351.0	127.2	31.8	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2468	2700	1350.0	91.24	45.6	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
2469	4049	1349.7	49.87	16.6	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D Sabatini, K Bensch, R J Barrnett	J Cell Biol	1963	13975866	Yes
2470	1349	1349.0	34.6	34.6	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2471	1349	1349.0	29.49	29.5	Measuring information transfer	T Schreiber	Phys Rev Lett	2000	10991308	Yes
2472	4046	1348.7	156.01	52.0	Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.	Jack Bowden, George Davey Smith, Stephen Burgess	Int J Epidemiol	2015	26050253	Yes
2473	1348	1348.0	41.73	41.7	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2474	1348	1348.0	41.1	41.1	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2475	1348	1348.0	41.7	41.7	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2476	1348	1348.0	110.02	110.0	Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.	Jonas F Ludvigsson	Acta Paediatr	2020	32202343	Yes
2477	1347	1347.0	26.9	26.9	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2478	1347	1347.0	31.61	31.6	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2479	1346	1346.0	20.44	20.4	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2480	1346	1346.0	25.97	26.0	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2481	1345	1345.0	50.14	50.1	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2482	4035	1345.0	126.36	42.1	AChE-stained horizontal sections of the rat brain in stereotaxic coordinates.	G Paxinos, C R Watson, P C Emson	J Neurosci Methods	1980	6110810	Yes
2483	1345	1345.0	35.51	35.5	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2484	1345	1345.0	28.43	28.4	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2485	6721	1344.2	182.55	36.5	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2486	2688	1344.0	93.61	46.8	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2487	1344	1344.0	33.64	33.6	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2488	1344	1344.0	25.86	25.9	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2489	1344	1344.0	45.21	45.2	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2490	5375	1343.8	123.84	31.0	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2491	2686	1343.0	61.46	30.7	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2492	1343	1343.0	39.76	39.8	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2493	1343	1343.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J Waddell	J Lab Clin Med	1956	13346201	Yes
2494	1343	1343.0	11.79	11.8	Immunological function of the thymus.	J F Miller	Lancet	1961	14474038	Yes
2495	2685	1342.5	64.39	32.2	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2496	2685	1342.5	83.47	41.7	Tumor-associated macrophages: from mechanisms to therapy.	Roy Noy, Jeffrey W Pollard	Immunity	2014	25035953	No
2497	1342	1342.0	41.97	42.0	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2498	4026	1342.0	139.69	46.6	Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.	Marina Colombo, Graça Raposo, Clotilde Théry	Annu Rev Cell Dev Biol	2014	25288114	No
2499	1341	1341.0	36.01	36.0	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2500	1341	1341.0	27.94	27.9	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2501	1341	1341.0	55.8	55.8	Rhythms for Cognition: Communication through Coherence.	Pascal Fries	Neuron	2015	26447583	No
2502	2681	1340.5	90.08	45.0	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
2503	1340	1340.0	30.24	30.2	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2504	1340	1340.0	34.05	34.0	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2505	2679	1339.5	71.81	35.9	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2506	1339	1339.0	59.54	59.5	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2507	2677	1338.5	59.73	29.9	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2508	1338	1338.0	35.57	35.6	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2509	1338	1338.0	38.92	38.9	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2510	1338	1338.0	25.62	25.6	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2511	2676	1338.0	64.72	32.4	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2512	2674	1337.0	61.48	30.7	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2513	1337	1337.0	28.57	28.6	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2514	1337	1337.0	25.14	25.1	A modified procedure for lead staining of thin sections.	G Millonig	J Biophys Biochem Cytol	1961	14474176	Yes
2515	1337	1337.0	23.0	23.0	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2516	2674	1337.0	67.46	33.7	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2517	1337	1337.0	38.03	38.0	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2518	4010	1336.7	100.64	33.5	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2519	1336	1336.0	34.99	35.0	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2520	1336	1336.0	63.12	63.1	Biological roles of glycans.	Ajit Varki	Glycobiology	2017	27558841	No
2521	1335	1335.0	41.95	42.0	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2522	1335	1335.0	64.13	64.1	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2523	2670	1335.0	54.14	27.1	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2524	2669	1334.5	73.17	36.6	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2525	2669	1334.5	80.43	40.2	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
2526	1334	1334.0	44.67	44.7	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2527	4001	1333.7	90.55	30.2	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2528	1333	1333.0	45.37	45.4	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2529	1333	1333.0	39.58	39.6	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2530	1333	1333.0	25.7	25.7	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
2531	1333	1333.0	47.08	47.1	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2532	1333	1333.0	27.21	27.2	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2533	1332	1332.0	33.25	33.2	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2534	1332	1332.0	32.91	32.9	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2535	5327	1331.8	117.48	29.4	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2536	3995	1331.7	102.72	34.2	Cognitive and emotional influences in anterior cingulate cortex.	G Bush, P Luu, M I Posner	Trends Cogn Sci	2000	10827444	Yes
2537	3994	1331.3	107.37	35.8	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2538	1330	1330.0	33.82	33.8	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2539	1330	1330.0	34.7	34.7	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2540	1330	1330.0	40.74	40.7	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2541	1330	1330.0	23.41	23.4	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2542	3990	1330.0	87.73	29.2	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2543	2660	1330.0	61.59	30.8	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2544	1329	1329.0	30.21	30.2	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2545	5315	1328.8	131.28	32.8	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2546	2657	1328.5	136.22	68.1	Sensitivity Analysis in Observational Research: Introducing the E-Value.	Tyler J VanderWeele, Peng Ding	Ann Intern Med	2017	28693043	Yes
2547	1328	1328.0	0.0	0.0	On the psychophysical law.	S S Stevens	Psychol Rev	1957	13441853	Yes
2548	5311	1327.8	228.64	57.2	Progressive statistics for studies in sports medicine and exercise science.	William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin	Med Sci Sports Exerc	2009	19092709	No
2549	2653	1326.5	55.78	27.9	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2550	1326	1326.0	47.99	48.0	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2551	2652	1326.0	59.91	30.0	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2552	2651	1325.5	58.24	29.1	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2553	1325	1325.0	50.7	50.7	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2554	1325	1325.0	30.07	30.1	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2555	1325	1325.0	43.52	43.5	Phenylpropanoid biosynthesis.	Thomas Vogt	Mol Plant	2010	20035037	No
2556	1324	1324.0	13.17	13.2	Cellular resistance to infection.	G B Mackaness	J Exp Med	1962	14467923	Yes
2557	1324	1324.0	40.49	40.5	Nanobodies: natural single-domain antibodies.	Serge Muyldermans	Annu Rev Biochem	2013	23495938	No
2558	2646	1323.0	60.26	30.1	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2559	1323	1323.0	50.67	50.7	Minority stress and mental health in gay men.	I H Meyer	J Health Soc Behav	1995	7738327	Yes
2560	9256	1322.3	231.31	33.0	Integrative genomics viewer.	James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov	Nat Biotechnol	2011	21221095	Yes
2561	1322	1322.0	29.81	29.8	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2562	1322	1322.0	42.59	42.6	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2563	2644	1322.0	106.08	53.0	Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.	Roel Nusse, Hans Clevers	Cell	2017	28575679	No
2564	2642	1321.0	46.54	23.3	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2565	1321	1321.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B Cloward	J Neurosurg	1958	13599052	Yes
2566	2641	1320.5	83.38	41.7	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2567	3960	1320.0	97.41	32.5	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2568	2640	1320.0	100.61	50.3	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
2569	1320	1320.0	31.61	31.6	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2570	1320	1320.0	22.96	23.0	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
2571	2638	1319.0	123.17	61.6	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2572	3957	1319.0	140.89	47.0	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2573	1319	1319.0	38.39	38.4	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2574	1319	1319.0	28.26	28.3	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2575	1319	1319.0	32.34	32.3	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2576	2637	1318.5	100.94	50.5	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2577	1318	1318.0	35.17	35.2	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2578	3953	1317.7	91.52	30.5	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2579	2635	1317.5	48.92	24.5	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2580	3952	1317.3	83.9	28.0	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2581	1317	1317.0	23.03	23.0	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2582	1317	1317.0	55.3	55.3	The Laboratory Rat: Relating Its Age With Human's.	Pallav Sengupta	Int J Prev Med	2013	23930179	Yes
2583	7900	1316.7	199.42	33.2	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2584	1316	1316.0	35.52	35.5	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2585	1316	1316.0	38.82	38.8	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2586	3947	1315.7	80.86	27.0	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2587	1315	1315.0	44.55	44.5	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2588	1315	1315.0	54.61	54.6	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2589	5258	1314.5	123.64	30.9	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
2590	2628	1314.0	68.0	34.0	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2591	2628	1314.0	70.2	35.1	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2592	1314	1314.0	27.89	27.9	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2593	1314	1314.0	28.74	28.7	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2594	3941	1313.7	93.24	31.1	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2595	3940	1313.3	101.92	34.0	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2596	1313	1313.0	16.98	17.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2597	1313	1313.0	33.95	34.0	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2598	1313	1313.0	33.68	33.7	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2599	1313	1313.0	69.38	69.4	ROS Are Good.	Ron Mittler	Trends Plant Sci	2017	27666517	No
2600	2625	1312.5	55.83	27.9	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2601	6562	1312.4	123.55	24.7	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2602	1312	1312.0	37.3	37.3	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2603	1312	1312.0	73.31	73.3	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2604	1312	1312.0	33.12	33.1	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2605	3936	1312.0	132.44	44.1	Job burnout.	C Maslach, W B Schaufeli, M P Leiter	Annu Rev Psychol	2001	11148311	Yes
2606	2623	1311.5	56.57	28.3	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2607	5245	1311.2	104.55	26.1	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2608	1311	1311.0	39.93	39.9	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2609	1310	1310.0	37.38	37.4	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2610	1310	1310.0	27.69	27.7	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2611	2620	1310.0	62.47	31.2	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2612	1310	1310.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F Scholander	J Biol Chem	1947	20281644	Yes
2613	1310	1310.0	40.84	40.8	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2614	5240	1310.0	257.16	64.3	Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range.	Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong	BMC Med Res Methodol	2014	25524443	Yes
2615	2619	1309.5	47.68	23.8	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
2616	1309	1309.0	34.62	34.6	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2617	1309	1309.0	69.88	69.9	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2618	1309	1309.0	48.82	48.8	Microtiter dish biofilm formation assay.	George A O'Toole	J Vis Exp	2011	21307833	Yes
2619	1309	1309.0	109.8	109.8	COVID-19 and African Americans.	Clyde W Yancy	JAMA	2020	32293639	Yes
2620	2617	1308.5	40.65	20.3	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2621	2616	1308.0	59.4	29.7	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2622	2616	1308.0	57.35	28.7	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2623	2615	1307.5	75.14	37.6	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2624	5229	1307.2	210.47	52.6	QUAST: quality assessment tool for genome assemblies.	Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler	Bioinformatics	2013	23422339	Yes
2625	1307	1307.0	24.45	24.4	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2626	2614	1307.0	40.25	20.1	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2627	1307	1307.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S Farr	J Infect Dis	1958	13611294	Yes
2628	1307	1307.0	41.83	41.8	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2629	1306	1306.0	35.64	35.6	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2630	1306	1306.0	37.85	37.9	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2631	1306	1306.0	35.7	35.7	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
2632	2608	1304.0	76.86	38.4	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2633	1304	1304.0	33.81	33.8	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2634	1304	1304.0	27.14	27.1	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2635	1304	1304.0	71.99	72.0	DLS and zeta potential - What they are and what they are not?	Sourav Bhattacharjee	J Control Release	2016	27297779	No
2636	7823	1303.8	195.55	32.6	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2637	2607	1303.5	38.25	19.1	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2638	2607	1303.5	0.0	0.0	Construct validity in psychological tests.	L J Cronbach, P E Meehl	Psychol Bull	1955	13245896	Yes
2639	2606	1303.0	77.35	38.7	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2640	1302	1302.0	31.87	31.9	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2641	1302	1302.0	44.58	44.6	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2642	1302	1302.0	21.7	21.7	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2643	3906	1302.0	87.81	29.3	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2644	2602	1301.0	43.32	21.7	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2645	1301	1301.0	42.05	42.0	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2646	1301	1301.0	37.06	37.1	Subcutaneous and visceral adipose tissue: structural and functional differences.	M Mohsen Ibrahim	Obes Rev	2010	19656312	No
2647	1301	1301.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J Berkson	Biometrics	1946	21001024	Yes
2648	1301	1301.0	44.71	44.7	PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints.	Chun Wei Yap	J Comput Chem	2011	21425294	Yes
2649	6504	1300.8	159.88	32.0	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2650	1300	1300.0	32.01	32.0	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2651	3899	1299.7	91.25	30.4	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2652	2598	1299.0	161.54	80.8	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2653	1299	1299.0	29.71	29.7	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2654	1298	1298.0	30.09	30.1	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2655	1298	1298.0	32.9	32.9	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2656	2596	1298.0	105.71	52.9	The Warburg Effect: How Does it Benefit Cancer Cells?	Maria V Liberti, Jason W Locasale	Trends Biochem Sci	2016	26778478	No
2657	1297	1297.0	31.04	31.0	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
2658	1297	1297.0	28.45	28.4	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2659	5184	1296.0	114.07	28.5	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2660	1296	1296.0	40.02	40.0	Evaluating the quality of medical care. 1966.	Avedis Donabedian	Milbank Q	2005	16279964	No
2661	1296	1296.0	38.86	38.9	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2662	3886	1295.3	127.39	42.5	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2663	2590	1295.0	82.82	41.4	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
2664	1295	1295.0	35.06	35.1	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2665	2590	1295.0	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A Edmondson, P E Steiner	Cancer	1954	13160935	Yes
2666	2590	1295.0	67.48	33.7	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2667	1294	1294.0	31.14	31.1	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2668	2588	1294.0	61.63	30.8	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
2669	1294	1294.0	23.41	23.4	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2670	1294	1294.0	27.2	27.2	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2671	1294	1294.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2672	2587	1293.5	64.31	32.2	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
2673	1293	1293.0	29.51	29.5	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2674	1293	1293.0	30.26	30.3	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2675	2585	1292.5	55.62	27.8	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2676	1292	1292.0	41.4	41.4	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2677	1292	1292.0	61.41	61.4	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
2678	2584	1292.0	59.84	29.9	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2679	1291	1291.0	42.44	42.4	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
2680	1291	1291.0	29.56	29.6	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2681	1291	1291.0	84.47	84.5	SARS-CoV-2 vaccines in development.	Florian Krammer	Nature	2020	32967006	No
2682	1290	1290.0	22.57	22.6	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2683	1290	1290.0	0.0	0.0	Agammaglobulinemia.	O C Bruton	Pediatrics	1952	14929630	Yes
2684	2579	1289.5	71.23	35.6	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2685	2579	1289.5	69.42	34.7	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2686	2578	1289.0	57.36	28.7	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2687	2578	1289.0	130.62	65.3	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2688	1289	1289.0	34.25	34.2	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2689	3867	1289.0	109.31	36.4	The Patient Health Questionnaire-2: validity of a two-item depression screener.	Kurt Kroenke, Robert L Spitzer, Janet B W Williams	Med Care	2003	14583691	Yes
2690	1289	1289.0	23.94	23.9	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2691	1289	1289.0	29.18	29.2	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
2692	2577	1288.5	59.01	29.5	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2693	1288	1288.0	36.63	36.6	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2694	1288	1288.0	37.35	37.4	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
2695	1288	1288.0	45.38	45.4	Plasma perspective on strong field multiphoton ionization.	P B Corkum	Phys Rev Lett	1993	10054556	Yes
2696	14167	1287.9	381.54	34.7	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2697	1287	1287.0	31.72	31.7	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2698	1287	1287.0	10.64	10.6	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2699	1287	1287.0	26.91	26.9	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2700	2573	1286.5	88.24	44.1	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2701	2573	1286.5	82.41	41.2	The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample.	Julie D Henry, John R Crawford	Br J Clin Psychol	2005	16004657	Yes
2702	5145	1286.2	184.78	46.2	The chemistry and applications of metal-organic frameworks.	Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi	Science	2013	23990564	Yes
2703	1286	1286.0	38.92	38.9	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2704	2572	1286.0	82.3	41.1	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2705	3858	1286.0	97.61	32.5	Atomic force microscope.	G Binnig, C F Quate, C Gerber	Phys Rev Lett	1986	10033323	Yes
2706	2571	1285.5	55.01	27.5	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2707	2571	1285.5	94.54	47.3	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
2708	1285	1285.0	46.95	47.0	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2709	1285	1285.0	30.41	30.4	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
2710	2570	1285.0	45.98	23.0	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2711	1285	1285.0	27.31	27.3	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
2712	2569	1284.5	46.73	23.4	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2713	1284	1284.0	34.63	34.6	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2714	1283	1283.0	56.17	56.2	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2715	2566	1283.0	63.43	31.7	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2716	1283	1283.0	55.96	56.0	Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction.	Alice Y Y Cheng	Can J Diabetes	2013	24070926	No
2717	2564	1282.0	60.86	30.4	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2718	1282	1282.0	34.1	34.1	Levels of racism: a theoretic framework and a gardener's tale.	C P Jones	Am J Public Health	2000	10936998	Yes
2719	2563	1281.5	23.76	11.9	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2720	1281	1281.0	39.0	39.0	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2721	1281	1281.0	31.91	31.9	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2722	2561	1280.5	65.73	32.9	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
2723	2561	1280.5	89.37	44.7	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2724	2560	1280.0	97.44	48.7	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
2725	8959	1279.9	251.92	36.0	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2726	2559	1279.5	52.69	26.3	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2727	1279	1279.0	43.11	43.1	Density matrix formulation for quantum renormalization groups.	S R White	Phys Rev Lett	1992	10046608	Yes
2728	1279	1279.0	32.11	32.1	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2729	1279	1279.0	40.58	40.6	Function and information content of DNA methylation.	Dirk Schübeler	Nature	2015	25592537	No
2730	3834	1278.0	91.15	30.4	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2731	1278	1278.0	42.47	42.5	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2732	2556	1278.0	62.75	31.4	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2733	2556	1278.0	51.94	26.0	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2734	1278	1278.0	37.48	37.5	Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE.	Louis B Rice	J Infect Dis	2008	18419525	No
2735	1278	1278.0	36.17	36.2	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2736	6386	1277.2	249.02	49.8	The Phyre2 web portal for protein modeling, prediction and analysis.	Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg	Nat Protoc	2015	25950237	Yes
2737	1277	1277.0	60.68	60.7	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2738	1277	1277.0	21.71	21.7	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2739	1277	1277.0	35.29	35.3	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2740	2553	1276.5	226.15	113.1	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2741	1276	1276.0	39.31	39.3	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
2742	1275	1275.0	33.52	33.5	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2743	1275	1275.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M Kalckar	J Biol Chem	1947	20285041	Yes
2744	2549	1274.5	61.49	30.7	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2745	3822	1274.0	170.78	56.9	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2746	2548	1274.0	48.92	24.5	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2747	2548	1274.0	156.25	78.1	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2748	2547	1273.5	78.9	39.5	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2749	2546	1273.0	68.69	34.3	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
2750	1273	1273.0	28.98	29.0	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2751	1273	1273.0	26.64	26.6	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
2752	1273	1273.0	36.15	36.1	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2753	1273	1273.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B Verney	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
2754	2544	1272.0	67.04	33.5	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2755	1272	1272.0	31.21	31.2	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2756	1271	1271.0	28.7	28.7	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2757	1271	1271.0	40.99	41.0	Photoplethysmography and its application in clinical physiological measurement.	John Allen	Physiol Meas	2007	17322588	No
2758	2540	1270.0	76.08	38.0	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2759	1270	1270.0	25.57	25.6	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
2760	1270	1270.0	30.18	30.2	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2761	1270	1270.0	34.36	34.4	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2762	3809	1269.7	103.42	34.5	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2763	2539	1269.5	50.46	25.2	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2764	3808	1269.3	141.88	47.3	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
2765	2537	1268.5	57.15	28.6	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2766	2536	1268.0	49.08	24.5	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2767	1268	1268.0	31.33	31.3	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2768	2536	1268.0	66.64	33.3	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2769	2536	1268.0	64.04	32.0	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
2770	1267	1267.0	31.44	31.4	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2771	1266	1266.0	28.31	28.3	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2772	3798	1266.0	73.22	24.4	Exosomes: composition, biogenesis and function.	Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
2773	1266	1266.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A Berg	J Gen Psychol	1948	18889466	Yes
2774	1266	1266.0	34.98	35.0	T follicular helper cell differentiation, function, and roles in disease.	Shane Crotty	Immunity	2014	25367570	No
2775	5063	1265.8	116.74	29.2	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2776	3795	1265.0	112.08	37.4	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2777	6325	1265.0	152.82	30.6	Jalview Version 2--a multiple sequence alignment editor and analysis workbench.	Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton	Bioinformatics	2009	19151095	Yes
2778	2529	1264.5	13.32	6.7	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J Todaro, H Green	J Cell Biol	1963	13985244	Yes
2779	7586	1264.3	217.78	36.3	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2780	1264	1264.0	31.57	31.6	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
2781	3791	1263.7	90.18	30.1	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2782	13898	1263.5	355.99	32.4	Frailty in older adults: evidence for a phenotype.	L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie	J Gerontol A Biol Sci Med Sci	2001	11253156	Yes
2783	1263	1263.0	32.15	32.1	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2784	2525	1262.5	67.3	33.6	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2785	5049	1262.2	183.6	45.9	Near-optimal probabilistic RNA-seq quantification.	Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter	Nat Biotechnol	2016	27043002	Yes
2786	1262	1262.0	26.78	26.8	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2787	2524	1262.0	85.43	42.7	Factors affecting wound healing.	S Guo, L A Dipietro	J Dent Res	2010	20139336	No
2788	3785	1261.7	118.26	39.4	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2789	2523	1261.5	50.94	25.5	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2790	1261	1261.0	30.39	30.4	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2791	1261	1261.0	36.15	36.1	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2792	1261	1261.0	25.98	26.0	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
2793	2522	1261.0	44.24	22.1	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2794	1261	1261.0	53.02	53.0	Inflammation, metaflammation and immunometabolic disorders.	Gökhan S Hotamisligil	Nature	2017	28179656	No
2795	1260	1260.0	33.85	33.9	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
2796	1260	1260.0	14.07	14.1	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
2797	2520	1260.0	55.96	28.0	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2798	1259	1259.0	63.26	63.3	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2799	1259	1259.0	26.77	26.8	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2800	1259	1259.0	53.6	53.6	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2801	5032	1258.0	144.76	36.2	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2802	1258	1258.0	25.74	25.7	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2803	1258	1258.0	25.69	25.7	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2804	1258	1258.0	29.5	29.5	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2805	1258	1258.0	41.97	42.0	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2806	1257	1257.0	34.65	34.6	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
2807	1257	1257.0	34.89	34.9	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2808	2514	1257.0	61.74	30.9	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2809	2514	1257.0	47.08	23.5	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2810	1257	1257.0	27.17	27.2	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2811	1257	1257.0	23.6	23.6	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
2812	1257	1257.0	46.89	46.9	Glutathione synthesis.	Shelly C Lu	Biochim Biophys Acta	2013	22995213	No
2813	3770	1256.7	111.59	37.2	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
2814	1256	1256.0	46.6	46.6	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2815	2512	1256.0	73.09	36.5	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2816	1256	1256.0	42.89	42.9	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2817	1256	1256.0	26.73	26.7	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2818	1256	1256.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M Reitan	J Consult Psychol	1955	13263471	Yes
2819	2511	1255.5	48.73	24.4	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2820	2511	1255.5	87.87	43.9	Nitric oxide synthases: regulation and function.	Ulrich Förstermann, William C Sessa	Eur Heart J	2012	21890489	No
2821	2511	1255.5	98.02	49.0	Unique features of long non-coding RNA biogenesis and function.	Jeffrey J Quinn, Howard Y Chang	Nat Rev Genet	2016	26666209	No
2822	1255	1255.0	32.22	32.2	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2823	1255	1255.0	35.37	35.4	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
2824	8782	1254.6	259.71	37.1	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
2825	5018	1254.5	104.98	26.2	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2826	2509	1254.5	62.95	31.5	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2827	1254	1254.0	30.52	30.5	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2828	1254	1254.0	28.6	28.6	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2829	2508	1254.0	48.7	24.4	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2830	2508	1254.0	88.24	44.1	Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.	John F Cryan, Timothy G Dinan	Nat Rev Neurosci	2012	22968153	No
2831	2507	1253.5	61.56	30.8	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2832	1253	1253.0	32.35	32.4	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2833	3759	1253.0	112.43	37.5	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2834	1253	1253.0	30.39	30.4	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2835	1253	1253.0	45.64	45.6	Energy metabolism in the liver.	Liangyou Rui	Compr Physiol	2014	24692138	No
2836	13777	1252.5	328.04	29.8	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2837	2505	1252.5	68.56	34.3	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2838	6262	1252.4	334.97	67.0	ModelFinder: fast model selection for accurate phylogenetic estimates.	Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin	Nat Methods	2017	28481363	Yes
2839	1252	1252.0	82.68	82.7	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2840	1252	1252.0	24.6	24.6	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2841	1252	1252.0	42.2	42.2	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
2842	1252	1252.0	31.49	31.5	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
2843	1252	1252.0	27.78	27.8	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2844	1252	1252.0	25.94	25.9	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2845	1252	1252.0	33.8	33.8	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2846	3755	1251.7	104.0	34.7	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2847	2503	1251.5	57.88	28.9	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
2848	2503	1251.5	63.55	31.8	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2849	1251	1251.0	24.86	24.9	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2850	5004	1251.0	131.1	32.8	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2851	1251	1251.0	39.34	39.3	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2852	5004	1251.0	187.48	46.9	Predicting effective microRNA target sites in mammalian mRNAs.	Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel	Elife	2015	26267216	Yes
2853	1250	1250.0	57.62	57.6	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2854	3749	1249.7	87.69	29.2	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2855	1249	1249.0	44.52	44.5	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2856	1249	1249.0	32.67	32.7	Bacteroides: the good, the bad, and the nitty-gritty.	Hannah M Wexler	Clin Microbiol Rev	2007	17934076	No
2857	2497	1248.5	62.66	31.3	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2858	2497	1248.5	66.71	33.4	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2859	2497	1248.5	63.92	32.0	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2860	6242	1248.4	232.89	46.6	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
2861	1248	1248.0	20.53	20.5	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2862	2495	1247.5	55.96	28.0	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2863	2495	1247.5	64.76	32.4	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2864	1247	1247.0	52.1	52.1	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2865	1247	1247.0	41.38	41.4	Enhancing the quality and credibility of qualitative analysis.	M Q Patton	Health Serv Res	1999	10591279	No
2866	1247	1247.0	28.94	28.9	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
2867	1247	1247.0	38.28	38.3	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2868	1247	1247.0	20.55	20.6	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A Rose	Bull World Health Organ	1962	13974778	Yes
2869	1247	1247.0	32.04	32.0	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2870	1247	1247.0	49.94	49.9	The variable nature of cognitive control: a dual mechanisms framework.	Todd S Braver	Trends Cogn Sci	2012	22245618	Yes
2871	2493	1246.5	68.58	34.3	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2872	7478	1246.3	247.65	41.3	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke	J Clin Epidemiol	2008	18313558	Yes
2873	2492	1246.0	49.4	24.7	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2874	2492	1246.0	53.36	26.7	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2875	1246	1246.0	58.17	58.2	When to use the Bonferroni correction.	Richard A Armstrong	Ophthalmic Physiol Opt	2014	24697967	No
2876	2491	1245.5	90.32	45.2	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
2877	1245	1245.0	48.47	48.5	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
2878	2490	1245.0	102.96	51.5	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2879	1245	1245.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J Bateman	Heredity (Edinb)	1948	18103134	Yes
2880	1245	1245.0	38.43	38.4	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
2881	4977	1244.2	281.63	70.4	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
2882	2488	1244.0	63.31	31.7	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2883	1244	1244.0	27.54	27.5	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2884	1244	1244.0	28.36	28.4	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2885	1244	1244.0	98.03	98.0	The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020.	The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team	China CDC Wkly	2020	34594836	Yes
2886	2486	1243.0	47.83	23.9	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2887	1243	1243.0	22.62	22.6	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2888	1243	1243.0	35.38	35.4	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2889	1243	1243.0	0.0	0.0	A modification of receptor theory.	R P Stephenson	Br J Pharmacol Chemother	1956	13383117	Yes
2890	1243	1243.0	30.07	30.1	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2891	1242	1242.0	42.13	42.1	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
2892	1242	1242.0	45.36	45.4	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2893	1242	1242.0	29.78	29.8	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
2894	1241	1241.0	24.63	24.6	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2895	1241	1241.0	35.79	35.8	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2896	1241	1241.0	32.94	32.9	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
2897	1241	1241.0	0.0	0.0	Sequential tests for the detection of linkage.	N E Morton	Am J Hum Genet	1955	13258560	Yes
2898	3721	1240.3	182.89	61.0	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
2899	1240	1240.0	64.62	64.6	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2900	1240	1240.0	33.27	33.3	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2901	2479	1239.5	66.02	33.0	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2902	19832	1239.5	562.19	35.1	New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).	E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij	Eur J Cancer	2009	19097774	No
2903	9916	1239.5	253.58	31.7	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
2904	2478	1239.0	76.5	38.2	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2905	1239	1239.0	32.38	32.4	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2906	1239	1239.0	24.3	24.3	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2907	2478	1239.0	43.64	21.8	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2908	1238	1238.0	39.07	39.1	The Danish Register of Causes of Death.	Karin Helweg-Larsen	Scand J Public Health	2011	21775346	Yes
2909	2475	1237.5	57.23	28.6	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2910	1237	1237.0	29.85	29.9	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
2911	2474	1237.0	61.24	30.6	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2912	2474	1237.0	53.34	26.7	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N Ames, D T Dubin	J Biol Chem	1960	13793161	Yes
2913	1237	1237.0	28.95	28.9	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2914	1237	1237.0	32.29	32.3	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
2915	3708	1236.0	116.43	38.8	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
2916	1236	1236.0	26.4	26.4	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2917	1236	1236.0	37.36	37.4	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2918	3707	1235.7	115.5	38.5	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2919	2471	1235.5	64.88	32.4	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2920	2470	1235.0	48.29	24.1	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2921	1235	1235.0	37.38	37.4	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
2922	1235	1235.0	54.81	54.8	The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health.	Lisa Bowleg	Am J Public Health	2012	22594719	Yes
2923	1235	1235.0	74.97	75.0	Information bias in health research: definition, pitfalls, and adjustment methods.	Alaa Althubaiti	J Multidiscip Healthc	2016	27217764	No
2924	1234	1234.0	32.38	32.4	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2925	1234	1234.0	31.05	31.1	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2926	2467	1233.5	226.86	113.4	The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.	Hussin A Rothan, Siddappa N Byrareddy	J Autoimmun	2020	32113704	No
2927	2466	1233.0	75.32	37.7	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
2928	1233	1233.0	45.34	45.3	The evolving concept of health literacy.	Don Nutbeam	Soc Sci Med	2008	18952344	Yes
2929	1233	1233.0	55.57	55.6	Salience processing and insular cortical function and dysfunction.	Lucina Q Uddin	Nat Rev Neurosci	2015	25406711	No
2930	8627	1232.4	297.53	42.5	Metagenomic biomarker discovery and explanation.	Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower	Genome Biol	2011	21702898	Yes
2931	4928	1232.0	157.45	39.4	Validation of a combined comorbidity index.	M Charlson, T P Szatrowski, J Peterson, J Gold	J Clin Epidemiol	1994	7722560	Yes
2932	1232	1232.0	38.66	38.7	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
2933	1231	1231.0	49.47	49.5	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2934	1231	1231.0	43.52	43.5	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
2935	1231	1231.0	30.18	30.2	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
2936	1231	1231.0	27.75	27.8	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2937	6153	1230.6	192.46	38.5	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2938	1230	1230.0	44.11	44.1	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2939	2460	1230.0	68.3	34.1	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2940	1230	1230.0	37.93	37.9	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
2941	1229	1229.0	21.84	21.8	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2942	1229	1229.0	22.66	22.7	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2943	2457	1228.5	39.46	19.7	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2944	1228	1228.0	45.07	45.1	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2945	1228	1228.0	27.27	27.3	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2946	2456	1228.0	72.65	36.3	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
2947	2455	1227.5	58.83	29.4	Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.	R P Rao, D H Ballard	Nat Neurosci	1999	10195184	Yes
2948	2454	1227.0	65.7	32.9	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2949	2454	1227.0	48.73	24.4	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
2950	1227	1227.0	31.28	31.3	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
2951	7360	1226.7	205.31	34.2	Genome engineering using the CRISPR-Cas9 system.	F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang	Nat Protoc	2013	24157548	Yes
2952	6131	1226.2	247.06	49.4	Integrating single-cell transcriptomic data across different conditions, technologies, and species.	Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija	Nat Biotechnol	2018	29608179	Yes
2953	1226	1226.0	55.26	55.3	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
2954	1226	1226.0	32.03	32.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
2955	1226	1226.0	32.98	33.0	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
2956	1226	1226.0	24.48	24.5	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2957	1226	1226.0	25.17	25.2	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
2958	2451	1225.5	54.22	27.1	Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.	G K McMaster, G G Carmichael	Proc Natl Acad Sci U S A	1977	73185	Yes
2959	1225	1225.0	26.33	26.3	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2960	1224	1224.0	33.78	33.8	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
2961	1224	1224.0	30.94	30.9	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2962	2446	1223.0	63.1	31.6	The ubiquitin code.	David Komander, Michael Rape	Annu Rev Biochem	2012	22524316	No
2963	2446	1223.0	94.47	47.2	Kraken: ultrafast metagenomic sequence classification using exact alignments.	Derrick E Wood, Steven L Salzberg	Genome Biol	2014	24580807	Yes
2964	1222	1222.0	25.71	25.7	Antigen-presenting function of the macrophage.	E R Unanue	Annu Rev Immunol	1984	6242349	No
2965	1222	1222.0	22.2	22.2	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
2966	1222	1222.0	22.07	22.1	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2967	1222	1222.0	15.07	15.1	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M Van Rossum	Arch Int Pharmacodyn Ther	1963	13996119	Yes
2968	1222	1222.0	34.87	34.9	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2969	1222	1222.0	30.8	30.8	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2970	1222	1222.0	33.83	33.8	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2971	1221	1221.0	20.17	20.2	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2972	1221	1221.0	35.1	35.1	The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.	R G Pertwee	Br J Pharmacol	2008	17828291	No
2973	1220	1220.0	28.69	28.7	Growth factors and cancer.	S A Aaronson	Science	1991	1659742	No
2974	1220	1220.0	25.27	25.3	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	N

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