Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3894 papers with ECcit ≥ 1052.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 47, July 2024

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1224530224530.05000.125000.1Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2172867172867.07152.27152.2A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328569771424.20.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
412249561247.53039.881519.9Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54525145251.01394.651394.7A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63681836818.01190.251190.2Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76439132195.51935.87967.9Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83022930229.0819.62819.6Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92796127961.0887.24887.2The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102781227812.0612.63612.6MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112690326903.0635.36635.4MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
122595825958.0673.6673.6A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
132473024730.0566.79566.8A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142442924429.0761.83761.8Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
156626022086.72514.65838.2"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
166596721989.01667.57555.9DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
174264921324.51326.58663.3Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
182019420194.0256.66256.7The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
192008220082.0689.86689.9Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
204011520057.51240.28620.1The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
211953419534.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
221823518235.0509.33509.3Projector augmented-wave method. P E BlöchlPhys Rev B Condens Matter19949976227Yes
233636218181.01720.52860.3Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
243581217906.01512.9756.5The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
255348817829.31984.84661.6Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
261721717217.0635.24635.2A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
271699416994.0721.44721.4RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
281695916959.0425.7425.7Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
291675516755.0688.1688.1Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
301633116331.0671.84671.8A power primer. J CohenPsychol Bull199219565683Yes
311620116201.0447.95447.9High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
323236216181.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
331573115731.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
341539115391.0386.41386.4MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
353077315386.5977.13488.6Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
364600515335.01365.13455.0Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
374535815119.31296.44432.1CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
383016415082.01211.14605.6The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
392994414972.0757.21378.6Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
404458014860.01654.11551.4Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
412970314851.51116.14558.1Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
421442814428.0564.06564.1Catalase in vitro. H AebiMethods Enzymol19846727660Yes
434160013866.70.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
441325713257.0680.32680.3Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
456320512641.01812.75362.6Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
461253912539.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
472502212511.0516.13258.1Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
481242812428.0398.62398.6Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
492480612403.01017.64508.8The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
502469712348.5678.27339.1Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmüllerPhys Rev B Condens Matter19969984901Yes
511228512285.0314.04314.0Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
523600612002.01272.54424.2Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
532394811974.0522.64261.3Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
541196011960.0136.78136.8The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
551189711897.0359.41359.4The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
561189311893.0558.4558.4Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
572366711833.5639.75319.9Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
581173711737.0386.97387.0Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
593332511108.31301.67433.9Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
601092410924.0417.32417.3A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
611089310893.0379.03379.0Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
621084210842.0434.77434.8Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
632156110780.5558.96279.5A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
642115410577.0809.98405.0MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
651053710537.0365.91365.9Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
662103310516.5460.8230.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
673144610482.0818.16272.7VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
682072010360.0890.79445.4The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
693104710349.01046.33348.8NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
704108410271.01587.57396.9Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
714103210258.01172.91293.2Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
722033510167.5437.65218.8KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
731001710017.0203.95203.9Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
74197969898.0372.12186.1The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
7598759875.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7696479647.0271.99272.0Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7795349534.0198.42198.4Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
7895289528.0253.0253.0Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
7995189518.0410.19410.2Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8095139513.0319.67319.7Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
8194929492.0429.32429.3Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
82189639481.5491.75245.9A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
8393719371.0248.57248.6Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
8493109310.0268.77268.8Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
8592829282.0240.3240.3RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
8692739273.0271.33271.3The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
8792569256.0264.03264.0Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
8891739173.0259.77259.8The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
89365459136.21343.05335.8A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
90182269113.0382.03191.0The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
9190329032.0233.18233.2Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
92265518850.3680.32226.8Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9387908790.0177.69177.7Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
94175308765.0461.35230.7Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
95350408760.01132.86283.2Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
9687188718.0210.62210.6PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
9786878687.0225.86225.9Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
98519328655.33444.0574.0Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
9986238623.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
100172358617.5378.29189.1Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10185338533.0180.89180.9The functions of animal microRNAs. Victor AmbrosNature200415372042No
10284368436.0221.78221.8Canonical dynamics: Equilibrium phase-space distributions. W G HooverPhys Rev A Gen Phys19859895674Yes
10382938293.0351.75351.8UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
104247258241.7657.48219.2edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
10582398239.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
10682218221.0215.16215.2Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
107245928197.31373.47457.8MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
10881598159.0407.79407.8SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
10981478147.0240.34240.3AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
11080968096.0195.29195.3Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
11178947894.0365.39365.4Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
112236527884.0696.44232.1The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
11378607860.0217.75217.8"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
114156077803.5380.8190.4MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
11577927792.0227.97228.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
11677877787.0216.48216.5The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
11777697769.0210.2210.2Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
118153997699.5345.68172.8Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11976937693.0153.21153.2Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
12076347634.0219.5219.5Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
12176327632.0220.28220.3Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
12275617561.0186.64186.6Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12375217521.0160.54160.5Chromatin modifications and their function. Tony KouzaridesCell200717320507No
124149597479.5502.96251.5Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
125224367478.7882.11294.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
126221517383.7672.17224.1Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
127147517375.5351.39175.7BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
12873617361.0123.78123.8A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
12973547354.0243.66243.7Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
130514677352.41325.75189.4Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
131146487324.0451.2225.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
13272227222.0229.12229.1The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
13371627162.0215.9215.9The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
13470527052.0192.12192.1TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
135281647041.0922.22230.6G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
13669516951.0244.57244.6The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
137137296864.5349.51174.8Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
13868386838.0183.6183.6The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
139474516778.77186.711026.7Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
14065996599.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
141131556577.5713.21356.6Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14265756575.0173.65173.7A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
143131426571.0307.73153.9Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
14465636563.0214.78214.8Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
145196586552.7552.73184.2A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
14665436543.0172.3172.3Adhesion receptors of the immune system. T A SpringerNature19901974032No
147130676533.50.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
14865196519.0129.51129.5Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
14965126512.0169.13169.1Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
150129806490.0305.68152.8WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
151128996449.5357.25178.6EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
15263966396.0129.35129.3Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
15363586358.0150.14150.1Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
15463436343.0135.17135.2p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
15563356335.0110.71110.7A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
156125786289.0527.18263.6Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
157125636281.5431.52215.8The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15862746274.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
15962166216.0135.87135.9Inflammation in atherosclerosis. Peter LibbyNature200212490960No
16062056205.0214.12214.1An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
16161886188.0145.81145.8Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
16261796179.0144.51144.5Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
16361566156.0141.42141.4Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
164122856142.5342.38171.2RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
165122456122.5433.9216.9A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
166182756091.7907.08302.4Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16760856085.0149.22149.2Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
16860856085.0113.99114.0BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16960296029.0152.78152.8G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
17060276027.0152.27152.3Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
171239675991.8771.25192.8Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
17259795979.0144.47144.5Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
173118875943.5288.6144.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
17459085908.0136.5136.5Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
175116735836.5797.29398.6A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
176116015800.5267.78133.9Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17757885788.0178.79178.8Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
178115555777.5315.75157.9Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
179115265763.0251.42125.7One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18057485748.074.4674.5The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
181172345744.7606.91202.3Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
18257045704.0142.93142.9Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
183113925696.0470.3235.2The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
184113735686.5251.26125.6Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
18556685668.0253.08253.1Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
18656425642.0157.75157.8A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
187112695634.5297.84148.9Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
18856185618.0124.51124.5MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
189112335616.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
19056115611.0177.83177.8jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
19155845584.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
19255565556.0137.41137.4Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
19355505550.0104.27104.3Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
19455435543.093.2193.2Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
19555375537.0220.73220.7Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
19655115511.0119.71119.7The biochemistry of apoptosis. M O HengartnerNature200011048727No
197109925496.0255.82127.9A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
19854845484.0180.7180.7Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
19954825482.093.1793.2Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
200164195473.0494.43164.8A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
201109265463.0288.37144.2Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
202108465423.0230.23115.1Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
203108235411.5973.2486.6Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
204107655382.5275.76137.9Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
205107415370.5356.63178.3Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
206107055352.5299.93150.0MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
20753415341.0158.45158.4Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
20853395339.0137.37137.4The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
20953125312.0162.74162.7Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
21052975297.0135.07135.1New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
21152935293.0139.67139.7Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
212264355287.0714.01142.8The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
21352765276.0127.8127.8The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
21452705270.0102.73102.7Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
21552695269.0254.16254.2Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
21652625262.0152.13152.1Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
217157725257.3591.89197.3The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
218104995249.5490.47245.2A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
219104825241.00.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
22052185218.0142.43142.4How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
22152085208.0189.41189.4Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
22251925192.0197.55197.6Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
22351915191.068.2168.2Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
22451795179.052.652.6The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
22551685168.0116.96117.0Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
226103205160.0226.1113.0MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
227154795159.7381.54127.2Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
228102975148.5366.7183.3The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
22951195119.0124.58124.6Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
230101945097.0271.25135.6Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
23150945094.0101.73101.7Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
232101735086.5242.27121.1Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
23350855085.0187.09187.1Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
234101355067.5220.45110.2The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23550625062.0102.01102.0Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23650185018.0197.63197.6The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
23750085008.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
238199504987.5510.24127.6Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
239149324977.3539.07179.7Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
240247924958.41079.81216.0MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
24149504950.0131.58131.6A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
242296554942.51037.86173.0Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
243147854928.31048.74349.6Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
24498434921.5234.74117.4A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
24549114911.0136.64136.6Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
24649074907.0228.59228.6Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
24797954897.5352.49176.2Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
24848964896.0115.57115.6The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
249146034867.7393.49131.2Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
25048404840.097.8297.8An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
25148284828.090.6190.6DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
252144494816.3357.96119.3A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
253240474809.4436.2887.3An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
25448084808.0146.76146.8Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25595844792.0259.12129.6The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
256143714790.31302.75434.2Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
257143614787.00.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
25847804780.054.6154.6Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
25947664766.0107.18107.2ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
26047594759.0104.64104.6Cancer cell cycles. C J SherrScience19968939849No
26194964748.0158.1679.1A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
26247394739.0174.28174.3FreeSurfer. Bruce FischlNeuroimage201222248573No
26394454722.5216.26108.1Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26494214710.5173.6386.8Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
26594124706.0237.36118.7Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
26646984698.0157.0157.0The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
26793804690.0154.0277.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
26893644682.0319.46159.7Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
26946814681.0103.2103.2Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
270140344678.0485.53161.8Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
271140254675.0306.34102.1Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
27246744674.0214.68214.7The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
27346734673.0130.11130.1Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
274140094669.7556.83185.6A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
27546504650.0119.23119.2Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
27646434643.0120.89120.9A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
277185444636.0533.44133.4MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
27846334633.0102.87102.9Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
27992444622.0252.96126.5Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
280184684617.0317.0879.3A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
28146164616.039.7239.7The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
28292104605.0335.85167.9Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
28345724572.0142.41142.4Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
28491264563.0202.88101.4Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
285136614553.7600.36200.1Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
28691044552.0139.7669.9Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
28745474547.093.7193.7Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28845194519.097.1597.2ras genes. M BarbacidAnnu Rev Biochem19873304147No
28944974497.0117.31117.3The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
29089904495.0370.98185.5phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
29189464473.0214.08107.0Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
29289344467.00.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
29344654465.090.3290.3Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
29444604460.0102.51102.5Cancer. p53, guardian of the genome. D P LaneNature19921614522No
295267204453.3924.05154.0Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
29644434443.0105.58105.6Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
29744374437.0107.92107.9A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
29888574428.5237.53118.8A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
29943984398.090.4490.4Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
30087954397.5220.75110.4Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30187734386.5202.94101.5SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
30287674383.5160.9480.5A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
303131374379.0420.82140.3Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
30443794379.083.7383.7The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
305131364378.7474.43158.1HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
30643524352.0218.76218.8Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
307260474341.2954.43159.1MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
30843374337.0112.04112.0Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
309130114337.0636.94212.3Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
31043314331.083.8583.8The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
31143294329.0157.98158.0EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31243144314.0101.51101.5Mechanisms of angiogenesis. W RisauNature19979109485No
31343044304.0128.91128.9Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
31485954297.5248.83124.4Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
31585894294.5319.59159.8The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
31685884294.0124.1862.1Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
317128574285.7558.78186.3Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
31885694284.5355.5177.8The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
31942724272.0113.43113.4The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
320128014267.0761.39253.8Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
32142624262.092.5692.6Apoptosis by death factor. S NagataCell19979039262No
32242514251.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
32384904245.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
32442384238.090.2990.3Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
325169514237.8534.35133.6A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
32642374237.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
32742334233.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
32842294229.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
32942284228.087.4887.5The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
330169064226.5507.09126.8clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
33142244224.0158.65158.7Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
33242174217.0110.21110.2Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
33342154215.094.0894.1Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
334126364212.0415.26138.4featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
335252184203.0826.12137.7Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
33642004200.091.2991.3Atherosclerosis. A J LusisNature200011001066No
33741994199.075.7675.8Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
33883794189.5224.76112.4Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
33941804180.087.2587.2Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
34041594159.092.3992.4PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
341124674155.7463.11154.4A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
34241544154.0108.48108.5Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
343290724153.1640.3391.5UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
34441524152.049.6449.6Bone: formation by autoinduction. M R UristScience19655319761Yes
34582794139.5178.2389.1Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
34641394139.0173.37173.4Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
34741344134.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
348165324133.0620.34155.1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
34982394119.5220.03110.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35082214110.5304.15152.1Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
35141084108.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
35281934096.5262.25131.1DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35340924092.0128.29128.3Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
35440754075.0126.67126.7Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
35540704070.0150.18150.2A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
35640664066.0193.19193.2Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
35740614061.084.4484.4The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
35840524052.0176.31176.3A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
359121224040.7631.36210.5Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
36040404040.099.4199.4The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
36140374037.0109.54109.5Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
36280624031.0206.14103.1tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
36340314031.0127.02127.0How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
36440124012.078.8378.8Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
365360864009.6914.27101.6The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
36640094009.0136.19136.2Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36740014001.0103.6103.6Integrins: a family of cell surface receptors. R O HynesCell19873028640No
368159703992.5582.15145.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
36939823982.0106.92106.9What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
37039763976.069.7969.8Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
37139693969.0128.41128.4Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
37279333966.5220.33110.2Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
37339583958.097.3497.3Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
37439563956.0115.54115.5Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
37578983949.0149.4774.7A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
376118303943.3449.65149.9HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
377118013933.7302.44100.8Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
37839333933.099.6599.7Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
37978463923.0219.66109.8Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
38078443922.0199.4499.7Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38139223922.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
38239133913.0155.67155.7Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
38339053905.0103.41103.4Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
38439053905.0104.17104.2Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
38539033903.0120.5120.5Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
38638933893.084.0484.0Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
387116783892.7316.96105.7Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
38838873887.084.6284.6Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
38938843884.080.2980.3Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
39038783878.0122.03122.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
39138733873.0128.65128.7Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
39277313865.5146.373.2Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
39338613861.0131.59131.6Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
39476733836.5189.3194.7Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
395152973824.2357.5489.4Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
39638233823.0101.73101.7Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
39738223822.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
39838223822.097.297.2Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
39938213821.091.1591.2Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
40038213821.097.7297.7Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
40138203820.0108.25108.2Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
40238113811.0103.19103.2Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
40338083808.095.2495.2The origins and the future of microfluidics. George M WhitesidesNature200616871203No
40475983799.0254.01127.0FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
405189623792.4738.16147.6The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
40637923792.080.6480.6A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
40737913791.084.3784.4Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
40837913791.093.5893.6Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
40937883788.080.6580.7Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41037863786.073.9774.0Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
41137663766.0109.12109.1What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41275323766.0181.991.0Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
41337603760.077.3377.3TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
41437583758.0158.39158.4Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
41575113755.5209.29104.6BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41637543754.0118.62118.6genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
41737493749.0107.3107.3Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
41837473747.087.1787.2Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
41937433743.089.1489.1Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
420112183739.3215.9572.0Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
42174763738.0188.9994.5The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
42237373737.0122.64122.6Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42337313731.0169.77169.8Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
42474553727.5165.2882.6Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
425148763719.0384.2496.1Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
42674273713.5298.39149.2The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
42737083708.098.9198.9A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
42837033703.059.8259.8A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
42973843692.0177.4488.7The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
43036803680.0106.27106.3Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
43136743674.066.2566.2Somatic generation of antibody diversity. S TonegawaNature19836300689No
43273443672.0161.880.9Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
43373423671.0252.64126.3Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
43436643664.0105.74105.7Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
43536623662.088.8988.9I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
43673193659.5183.3291.7An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43736583658.0102.61102.6EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
43836563656.0103.21103.2Graphene: status and prospects. A K GeimScience200919541989Yes
43936523652.0106.33106.3Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
44036443644.085.3185.3Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
44136403640.094.6994.7The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
44236353635.0100.73100.7Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
443145193629.8464.87116.2A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
44472353617.5177.4488.7The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
445216973616.2989.21164.9Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44636023602.0108.22108.2Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
44735953595.091.3791.4RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
44835923592.084.5884.6Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
44935763576.0111.38111.4DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
450106773559.0258.6386.2Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
45135533553.074.4574.5Profile hidden Markov models. S R EddyBioinformatics19989918945No
45235463546.071.0171.0Mammalian neural stem cells. F H GageScience200010688783No
45335343534.096.9296.9Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
45470513525.5360.14180.1Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
45535233523.080.1180.1Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
45635233523.0163.54163.5Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
45735223522.0108.43108.4Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
45835173517.066.966.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
45935153515.080.1980.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
46070253512.5147.3373.7A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
46135113511.053.9453.9Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
46235113511.091.2691.3Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
46370213510.5126.5963.3Translating the histone code. T Jenuwein, C D AllisScience200111498575No
46435093509.0104.74104.7Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
465175203504.0495.8699.2Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
46635013501.0112.64112.6Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
46735003500.083.7983.8Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46834983498.056.3856.4Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
46969713485.582.6241.3Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
47034793479.062.2662.3Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
47134773477.0107.86107.9Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
47234753475.085.8585.8How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
47334713471.084.9184.9The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
474104133471.0394.47131.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
47534653465.080.8580.8The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
47634633463.054.7654.8The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
477103893463.0256.4785.5Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
47834623462.086.3386.3The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
47934553455.0135.55135.6Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
48068993449.5174.1487.1Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
48134403440.093.9493.9Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
48268723436.0163.0481.5"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
48334323432.074.6674.7Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
48434323432.0126.39126.4You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
48534303430.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
486102833427.7455.44151.8Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
48734253425.086.7286.7Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
48868363418.0135.3367.7Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
489170673413.41189.73237.9MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
49034083408.0153.28153.3The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
49167873393.5173.2286.6TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
49233853385.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
493101353378.3126.7242.2The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
49433733373.082.382.3The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49567443372.0185.0692.5Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
496101113370.3361.04120.3Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
49733623362.0107.61107.6No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
49833583358.076.5876.6Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
49933573357.094.7994.8Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
50033463346.068.6668.7The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
50166893344.5158.2879.1Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50266883344.0128.1764.1The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50366613330.5142.3371.2Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
50433303330.098.9799.0adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
50566583329.0206.6103.3The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
50633253325.068.268.2Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
50733213321.080.6480.6Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
50833053305.084.0984.1Gene regulation by steroid hormones. M BeatoCell19892644044No
50932893289.043.5743.6Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
51032843284.064.4164.4The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
51132823282.067.2667.3Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51265543277.0215.07107.5Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
51332763276.057.5857.6Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
51432733273.089.3289.3Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
51565293264.5218.39109.2Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
51632623262.060.2560.2Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
51732573257.086.6186.6ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
518130193254.8301.675.4Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
51932513251.076.2976.3Photoelectrochemical cells. M GrätzelNature200111713540Yes
52064953247.5177.1488.6Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52132473247.073.9473.9Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
52264913245.5203.07101.5Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
52332413241.093.4993.5Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
52432363236.0109.73109.7Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
52532283228.069.6269.6Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
52632263226.063.6963.7STATs and gene regulation. J E DarnellScience19979287210No
52764493224.5196.6498.3Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
52832183218.0103.52103.5Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
52932173217.097.4697.5Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
53064143207.0154.0177.0Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
53131993199.065.4965.5CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
53231983198.066.866.8Protein folding and misfolding. Christopher M DobsonNature200314685248No
53331943194.067.2967.3Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53431663166.078.478.4The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
53563073153.5133.3666.7Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
53663043152.0152.7476.4Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
53731493149.090.6390.6Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
53862913145.5183.7591.9Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
53931423142.074.1874.2WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
54031413141.096.596.5Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54162803140.0206.35103.2Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54231363136.0112.67112.7Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
54331283128.066.0266.0Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
544125093127.2476.47119.1APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
54531273127.066.0866.1Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
54662473123.599.4749.7Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
54731223122.0120.87120.9Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
54831193119.0108.71108.7The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
549280693118.8603.867.1Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
55062373118.5151.7175.9In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
55162373118.5194.797.3Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
55293523117.3263.8988.0Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
55362193109.5156.7278.4Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
55493223107.3194.5364.8Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
55531073107.081.5481.5Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
55692833094.3312.66104.2Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
55730913091.077.5977.6Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
55830903090.076.0876.1Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
55930883088.089.1989.2Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
56030833083.072.9272.9Obesity as a medical problem. P G KopelmanNature200010766250No
56130793079.027.5227.5Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
56230783078.0123.99124.0Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
56361543077.0136.3668.2MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
56461523076.056.4228.2The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
56530763076.083.2583.2The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
56661413070.5162.2981.1The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
56730703070.085.6685.7Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
56861333066.5108.5654.3The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
56930663066.0105.66105.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
57061053052.5179.8489.9mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
57130513051.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
57260943047.0188.0394.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
57391373045.7223.3174.4ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
574121823045.5443.71110.9Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
57530393039.070.5170.5Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
57630373037.065.0265.0TGFbeta in Cancer. Joan MassaguéCell200818662538No
57730273027.045.945.9A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
57830263026.073.1273.1The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57930243024.056.5556.5Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
580241323016.5523.4265.4The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
58130133013.0102.17102.2What is value in health care? Michael E PorterN Engl J Med201021142528Yes
58230113011.086.9186.9Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
58390273009.0177.1759.1Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
58460103005.0143.0171.5Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
58530043004.0102.45102.5Measurement of pain. E C HuskissonLancet19744139420Yes
58630043004.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
58760073003.5190.0895.0Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
58830033003.0135.83135.8The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
589120123003.0284.371.1Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
59060063003.0258.49129.2GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
59189732991.0207.5169.2TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
59259752987.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
59359692984.5134.7967.4Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
59429832983.058.8558.9Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
59529802980.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
59629742974.051.8651.9The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
59789202973.3168.7756.3Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
59829712971.068.8568.8Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
59959412970.5125.1462.6Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
60059282964.0220.33110.2The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
60129632963.054.8554.9RNA interference. Gregory J HannonNature200212110901No
60229622962.094.1994.2An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
60329602960.085.4385.4Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
60429582958.091.3191.3Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
60529572957.073.6773.7Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
60659062953.0125.0862.5Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
60758992949.5185.5192.8Tissue engineering. R Langer, J P VacantiScience19938493529No
60888472949.0288.7296.2Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60929472947.089.7689.8Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
61088272942.3242.2280.7Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
61129402940.0109.65109.7KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
61258782939.0247.97124.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
61329342934.065.9966.0Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61429232923.068.8568.8MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
615204462920.9767.63109.7limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
616262622918.0830.9292.3STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
61758312915.5151.7375.9Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
61829082908.046.6946.7A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
61987232907.7201.1567.0The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62029042904.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
621319202901.8665.0960.5Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
62229002900.043.6643.7Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
62328992899.065.4265.4Calcium signaling. David E ClaphamCell200718083096No
62457912895.5161.9681.0Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
62528922892.068.4368.4Structure and function of telomeres. E H BlackburnNature19911708110No
62628922892.070.5570.5Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
62786732891.0439.92146.6Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
62857812890.5121.1660.6Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62928902890.0101.07101.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
63057792889.5178.0289.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
631115552888.8339.5784.9Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
63228872887.060.0360.0Principles of CDK regulation. D O MorganNature19957877684No
63386602886.70.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
63428812881.086.2786.3Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
63528802880.067.267.2Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
63628772877.0532.87532.9Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
63728752875.061.7961.8Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
63857502875.0126.7463.4Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
63957472873.5151.6775.8Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
64028682868.096.096.0Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
64128682868.049.6149.6A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
64228672867.050.8950.9One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
64328612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
64428602860.030.5830.6Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
64528582858.052.4852.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
64628492849.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
64785452848.3248.1282.7Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
64856942847.0248.69124.3Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
64928462846.061.1461.1Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
65028452845.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
65128442844.056.2956.3Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65228432843.055.4655.5A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
65328402840.071.3571.3Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
65428372837.055.7655.8Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65528362836.096.5396.5Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
65656492824.5140.0370.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
65728232823.081.9682.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
65828232823.0105.34105.3Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
65928212821.053.5653.6Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
66028122812.085.2285.2Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
66128122812.062.7162.7Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
66228112811.0122.11122.1Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
66356112805.5173.6486.8Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66428052805.090.390.3Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
66556102805.0113.1956.6Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
66655972798.5134.7867.4Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
66755972798.5152.9276.5The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
66827972797.047.647.6Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
66955912795.5193.1696.6A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
67055882794.0186.4393.2Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
67127942794.0126.44126.4Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
67255862793.0126.863.4Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
67383732791.0361.53120.5Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
674111332783.2300.8675.2Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
67583482782.7189.9763.3Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
67627802780.065.1865.2Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
67755572778.5265.91133.0Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
678111002775.0338.0684.5Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
679110982774.5494.43123.6IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
68055472773.5109.955.0Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
68127702770.069.5569.5Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68227702770.0108.93108.9A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
68327672767.069.9770.0The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
68482992766.3203.867.9Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
68527662766.0112.03112.0Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
68655192759.5200.06100.0Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
68755162758.0130.6165.3Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
68855112755.5133.666.8Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
68955052752.580.4940.2A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
69027512751.069.4569.5Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
69127472747.077.2877.3Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
69254892744.5140.7470.4A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
69354882744.0151.6775.8Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69427432743.066.266.2Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
69527432743.065.2865.3T cell exhaustion. E John WherryNat Immunol201121739672No
69654832741.5127.3963.7Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
69754712735.5166.9683.5Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
69827352735.070.5570.5Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
69927332733.079.679.6The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
70027292729.058.8858.9Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
70127282728.053.1653.2The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
70227282728.0115.72115.7Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
70327242724.082.1582.2SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
70454442722.0107.9354.0High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
70527212721.061.4461.4Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
70627182718.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
70781412713.7176.1858.7Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
70827132713.062.8962.9Memory--a century of consolidation. J L McGaughScience200010634773No
709108482712.01412.16353.0Cancer Statistics, 2021. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202133433946Yes
71027092709.071.4371.4The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
71154072703.5158.3279.2Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
71227022702.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
71327002700.060.8960.9Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
71454002700.0183.2491.6Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
71553982699.0157.9779.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
71653762688.0184.6592.3The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
71780642688.0237.3579.1FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
71880542684.7199.5266.5MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
719107322683.0227.9657.0Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
720107232680.8316.2679.1Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
72126772677.060.2160.2Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
72226742674.0150.92150.9Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
72326732673.058.0458.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
72426712671.051.5751.6Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
72526672667.024.8224.8Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
72679982666.0271.0390.3Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
72726592659.064.4264.4Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
72826582658.062.7362.7Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
72953112655.5165.0882.5Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
730159242654.0355.7559.3Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
73126502650.060.7860.8Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
73252952647.5163.2181.6Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73326422642.082.1382.1What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
73452802640.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
73526352635.083.1183.1Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
73652682634.0209.68104.8A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
73726342634.059.4559.5Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
73826332633.0102.89102.9Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
73952452622.5143.6571.8Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
74026212621.065.2965.3The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
74126202620.0105.66105.7The biology of oxygen radicals. I FridovichScience1978210504Yes
74252272613.5107.4153.7MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
74352262613.0117.4558.7Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
74426122612.0120.93120.9The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
74526122612.080.6280.6The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
74626102610.0106.16106.2Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
74752152607.5181.3390.7A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
74852122606.0101.5950.8Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
74952122606.00.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
75026012601.074.7974.8Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
75125922592.082.5182.5A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
75225892589.050.6950.7Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
75325882588.055.555.5G1 phase progression: cycling on cue. C J SherrCell19947954821No
75425872587.073.4773.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
75525852585.072.5672.6Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
75625822582.088.8888.9A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
75725812581.080.7480.7Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
75825802580.053.853.8Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
75925792579.056.6456.6Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
76025782578.073.5873.6Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
76125782578.062.2362.2Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
76251552577.5160.1180.1The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
76351552577.5167.3483.7The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
76451432571.599.8849.9Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
76551422571.074.5637.3A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
76625682568.062.0162.0Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
76725672567.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
76825662566.071.1671.2Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
76925642564.035.4635.5The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
77025612561.071.571.5Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
77125602560.068.5668.6Dominant forces in protein folding. K A DillBiochemistry19902207096No
77251202560.0126.3863.2Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
77325582558.052.2252.2Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
77425542554.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
77525482548.055.2755.3Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
77625462546.097.397.3The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
77725422542.062.1962.2A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
77825412541.0128.47128.5Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
77950662533.0275.57137.8A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
78025322532.050.8250.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
78125202520.065.3865.4Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
78225182518.064.5664.6The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
78325152515.077.377.3Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
784100132503.2405.37101.3Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
78550012500.5115.8657.9Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
78650002500.0220.22110.1Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
78724972497.074.7774.8Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
78874892496.3203.1667.7Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
78924952495.044.944.9Wnt signaling and cancer. P PolakisGenes Dev200010921899No
79074752491.7197.4965.8Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
79149832491.5180.9690.5Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
79249822491.099.8749.9Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
79374702490.0186.7462.2RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
79474662488.7195.6365.2Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
79524862486.076.7676.8The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
79649682484.0141.6370.8Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
79749622481.0119.8459.9Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
79849582479.0155.3877.7Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
79949572478.5128.5264.3UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
80049552477.5147.3673.7SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
80149532476.596.3548.2CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
80224742474.0111.75111.8Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
80324742474.061.6561.6Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
80474112470.3191.6463.9Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
80524622462.092.5292.5Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
80649232461.5121.9461.0A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
80724422442.081.2981.3Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
80824392439.047.3247.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
80924382438.054.2254.2Social controls on cell survival and cell death. M C RaffNature19921557121No
81024382438.065.6265.6Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
81124352435.061.3261.3Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
81273042434.7207.969.3Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
81397322433.0254.2563.6GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
81448642432.0108.154.0Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
81524312431.057.8557.9Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
81624302430.077.8377.8Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
81748542427.0129.3564.7Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
81848462423.0139.9170.0Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
81924232423.0109.74109.7Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82048442422.0120.6460.3The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
82148432421.5103.3351.7Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
82224202420.053.0353.0Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
82324162416.046.0946.1Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
82424132413.0119.91119.9The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
82524112411.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
82624082408.052.5552.5Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
82724072407.082.0482.0Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
82848092404.593.0646.5The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
82924042404.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
83024012401.050.5150.5Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
83147982399.094.3647.2Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
83247952397.568.634.3Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
83323962396.075.8575.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
83447892394.5156.5278.3Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
83523942394.053.7553.8The inflammatory reflex. Kevin J TraceyNature200212490958No
83623942394.043.6943.7Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
83747752387.5142.2171.1Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
83847742387.0140.9570.5Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
83923852385.079.3479.3Working memory. A BaddeleyScience19921736359No
84023832383.052.2252.2The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
84147642382.0120.4560.2Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
84223762376.049.4549.5Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
84323762376.043.4843.5Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
84423752375.054.3754.4A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
84523752375.067.2367.2Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
84623712371.057.0857.1An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
84723712371.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
84894802370.0225.7956.4Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
84923652365.080.6980.7A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
85023632363.051.3351.3A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
85147252362.5127.8963.9Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
85223622362.098.5398.5The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
85323622362.059.759.7Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
85447242362.0161.5780.8The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
85547202360.0132.6766.3The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
85670632354.3154.2851.4The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
85723542354.062.0562.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
85823532353.091.9692.0Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
85947062353.097.6948.8New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
86047002350.0205.51102.8The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
86146982349.0103.2751.6Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
86223472347.051.4851.5Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
86323452345.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
86470332344.368.4222.8On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
86523442344.096.6496.6The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
86646882344.0127.3963.7Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86723392339.062.762.7Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
86846752337.5118.7359.4Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
86923372337.052.1252.1The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
87046722336.0104.4852.2Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
87123352335.070.9971.0A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
87246682334.0112.2856.1A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
87323332333.058.9759.0A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
87423312331.0126.98127.0Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
87546592329.5102.9351.5AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87646582329.0123.3461.7Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
87723272327.084.484.4Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
87846522326.0117.0158.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
87923252325.0104.29104.3Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
88023242324.066.2666.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
88146452322.587.5743.8A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
88246382319.0129.7664.9Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
88323192319.048.9148.9NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
88423172317.057.3257.3A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
88523172317.055.4255.4Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
88623162316.042.1942.2Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
88746292314.5113.1156.6Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
88846282314.0170.2185.1Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
88923122312.056.9456.9Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
89069292309.7199.0666.4GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hänzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
89123082308.079.2979.3Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
89223062306.049.7949.8Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89323052305.065.4865.5Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
89446082304.089.6444.8Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
89546072303.5123.6361.8Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
89646052302.576.1938.1On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
89723012301.059.4259.4MYC on the path to cancer. Chi V DangCell201222464321No
89846002300.072.1236.1High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
89922992299.053.453.4Specification of cerebral cortical areas. P RakicScience19883291116No
90022992299.055.8955.9The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
90122992299.032.1632.2Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
90222962296.076.7576.8Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
90322962296.057.0457.0Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
90445902295.0168.0884.0The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
90522952295.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
90622932293.071.9171.9Human error: models and management. J ReasonBMJ200010720363Yes
90791722293.0199.9650.0Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
90822932293.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
90945852292.5107.3253.7Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
91022922292.071.5971.6Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
91145832291.5115.5157.8A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
91245802290.087.4543.7The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
91322892289.074.7174.7Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
91422862286.060.4360.4The importance of selenium to human health. M P RaymanLancet200010963212No
91522832283.045.3645.4SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
91622822282.064.4764.5TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
91722822282.054.6454.6Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
91822812281.074.3374.3Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
91922782278.058.5158.5The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
92022762276.055.6655.7P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
92122752275.076.3776.4Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
92222722272.042.6242.6Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
92322682268.0117.05117.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
92422682268.055.3255.3Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
92545322266.0122.5461.3A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
92645312265.595.1347.6Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
92722632263.072.0272.0Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
92822622262.048.9649.0Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
92922602260.077.7877.8Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
93090402260.02084.85521.2Cancer statistics, 2022. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202235020204Yes
93122582258.068.7568.8Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
93222582258.057.4757.5Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
93322582258.065.5365.5Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
93422572257.044.3544.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
93522572257.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
93622552255.059.9960.0Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
93722542254.059.2259.2Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
93822472247.084.184.1Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
93944942247.0102.9851.5A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
94022462246.066.966.9PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
94122452245.058.1958.2Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
94222442244.053.2353.2Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
94344872243.5100.4250.2Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
94422432243.0142.52142.5Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
94522432243.056.1956.2RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
94622432243.065.1865.2Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
94722382238.061.2561.2Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
94822372237.055.0255.0Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
94944732236.5108.054.0Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
95022362236.0109.49109.5Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
95122342234.068.7468.7Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
95222322232.0107.64107.6Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
95322312231.057.2157.2Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
95444612230.5127.2163.6Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
95522302230.077.377.3Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
95644592229.589.244.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
95744592229.587.6743.8Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
95844562228.0128.7164.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
95922262226.0105.08105.1Metazoan MicroRNAs. David P BartelCell201829570994No
96022252225.049.1449.1The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
96122242224.070.070.0Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
96244472223.598.2749.1Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
963177852223.1560.8870.1The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
96422232223.041.6841.7Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96522212221.052.5652.6Mechanisms and genes of cellular suicide. H StellerScience19957878463No
96644402220.041.5120.8A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
967199772219.7929.26103.3Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
96822192219.057.3257.3Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
96944352217.5114.3657.2ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
97022142214.048.2348.2Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
97122142214.092.8992.9What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
97222122212.089.6389.6Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
97344242212.0112.8656.4Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
97422082208.065.965.9Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
97544142207.099.2349.6The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
97622062206.083.7183.7Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
97722022202.087.4687.5Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
97822012201.061.761.7Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
97921982198.056.4156.4Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
98021982198.059.4359.4Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
98143942197.095.8247.9Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
98221962196.068.3568.3Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
98387832195.8177.8944.5WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
98465842194.7254.0584.7Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
98543862193.0105.6252.8Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
98621922192.079.079.0Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
98721922192.048.6548.6Chemokines. B J RollinsBlood19979242519No
98821902190.071.4471.4Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
98921862186.046.5946.6Complement. First of two parts. M J WalportN Engl J Med200111287977No
99021842184.061.4861.5Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
99165472182.3194.1664.7The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
99221822182.052.9152.9Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
99387262181.5209.9952.5Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
99421782178.090.8190.8A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
99521782178.053.6753.7Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
99643552177.576.2538.1Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99721762176.054.3954.4The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
99865222174.0180.8160.3Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
99921732173.066.0566.0Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
100021722172.060.460.4Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
100121722172.048.3248.3A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
100221712171.058.6458.6The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
100321712171.0147.56147.6Obesity: global epidemiology and pathogenesis. Matthias BlüherNat Rev Endocrinol201930814686No
100443372168.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
100543342167.0103.1651.6Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
100664972165.7202.7267.6Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
100721642164.062.4262.4Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
100821632163.071.5571.5A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
100943212160.5150.1875.1Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
101021602160.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
101121592159.056.3356.3The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
101221582158.041.941.9Protein modules and signalling networks. T PawsonNature19957531822No
101321572157.054.9955.0Descending control of pain. Mark J MillanProg Neurobiol200212034378No
101421572157.049.1449.1Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
101543132156.5146.5373.3Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
101621522152.030.5230.5Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
101721512151.055.2555.2The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
101864362145.3186.1662.1Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
101921442144.045.7145.7Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
102042852142.5182.3391.2The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
102121412141.049.4749.5Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
102242812140.5100.6850.3Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
102321392139.039.9540.0NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
102442772138.571.0435.5A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
102521382138.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
102664132137.7129.043.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
102721362136.0115.58115.6The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
102842722136.0107.1353.6Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
102921362136.069.0169.0Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
103085422135.5183.3345.8MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
103142672133.5123.1461.6Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
103221332133.048.0948.1Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
103342652132.5103.5851.8Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
1034127922132.0285.9247.7NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
103521302130.064.1664.2The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
103621292129.051.0751.1Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
103721272127.042.2442.2Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
103863782126.0146.3448.8MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
103942512125.5111.0355.5The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
104021252125.092.3792.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
104142492124.580.5540.3The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
104221232123.064.6164.6Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
104363642121.3161.3753.8GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
104463622120.7119.3939.8Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
104563582119.3284.3694.8Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
104642362118.083.1941.6Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
104742322116.0134.5167.3A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
104821162116.064.1264.1The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
104984592114.8443.81111.0fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
105063432114.3130.0443.3EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
105142282114.0121.5660.8Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
105263412113.7149.049.7APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
105321122112.044.6344.6Mammalian G1 cyclins. C J SherrCell19938513492No
105442172108.582.4541.2Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
105542172108.5115.5257.8Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
105642102105.0106.8553.4Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
105721022102.050.850.8Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
105842042102.0127.0663.5Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
105921012101.036.6436.6Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
106021002100.052.5852.6Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
106120992099.060.4160.4The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
106220942094.049.4449.4Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
106320942094.083.583.5A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
106420942094.042.6642.7Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
106520922092.074.6374.6International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
106662672089.0191.563.8Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
106720882088.075.8875.9UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
106820882088.048.6648.7Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
106983502087.5304.7276.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
107041742087.0325.23162.6The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
107120862086.058.1358.1Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
107220832083.036.636.6Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
107341652082.5177.7588.9The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
1074124852080.8671.28111.9DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
1075332792079.91071.1966.9Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
107641582079.0109.0154.5The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
107720792079.038.1138.1Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
107820782078.045.3245.3Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
107941552077.5100.950.5Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
108041492074.5146.7473.4Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
108141472073.581.9941.0Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
108220722072.047.1347.1Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
108341422071.081.7940.9Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
108462132071.0184.8661.6Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
108520712071.053.2353.2Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
108620702070.050.4950.5Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
108720692069.059.5959.6ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
108820692069.0126.43126.4Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
108941342067.0185.5192.8Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
109020662066.070.970.9Purinergic nerves. G BurnstockPharmacol Rev19724404211No
109120612061.036.8736.9Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
109241202060.086.2343.1A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
109320592059.050.7650.8Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109441182059.0118.3259.2Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
109520572057.042.5642.6G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
109682272056.8269.6367.4Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
109720562056.052.8152.8The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
109841122056.080.7440.4Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
109982232055.8392.4298.1The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
110041092054.5109.2354.6The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
110120542054.041.4941.5Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
110241082054.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
110320542054.093.4393.4The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
110420502050.022.6522.6Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
110540992049.5100.9550.5Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
110661452048.3201.9167.3Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
110720482048.048.0348.0Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
110840952047.5111.0155.5New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
1109102362047.2238.3447.7Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
111040942047.0130.0565.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
111120462046.064.8564.8Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
111220462046.039.6639.7Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
111320432043.056.7756.8Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
111461172039.0196.965.6Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
111520392039.024.5924.6The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
111620382038.041.7141.7Molecular bases for circadian clocks. J C DunlapCell19999988221No
111720362036.072.8672.9Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
111840672033.5104.3652.2Building better batteries. M Armand, J-M TarasconNature200818256660No
111940672033.5118.1859.1Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
112040632031.598.4249.2Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
112120312031.047.6447.6Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
112240582029.0176.6588.3The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
112340542027.077.0838.5SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
112440522026.094.8547.4Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
112520252025.047.6147.6Calcium signaling. D E ClaphamCell19957834745No
112620252025.062.4462.4Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
112740472023.579.5739.8The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
112860702023.3228.776.2Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
112920222022.044.3644.4Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
113020222022.039.139.1CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
113120222022.051.6951.7What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
1132121312021.8376.9762.8Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
113320212021.079.3179.3Perception of risk. P SlovicScience19873563507Yes
113420212021.052.1452.1Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
113540392019.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
113620192019.059.8959.9Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
113740332016.597.3648.7Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
113820112011.058.3658.4Protein oxidation and aging. E R StadtmanScience19921355616No
113980412010.2302.0675.5The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114020092009.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
114120082008.041.6141.6XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
114220082008.034.9234.9ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
114320072007.046.7846.8DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
114420062006.042.4142.4Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
114520052005.050.450.4Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
114620052005.096.0596.0Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
114720042004.060.2660.3Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
114820012001.051.0451.0Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
114920012001.054.8754.9Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
115020002000.038.538.5Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
115159971999.0265.588.5Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
115219981998.043.8643.9Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
115319981998.083.3883.4A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
115419971997.036.6536.6In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
115559851995.0180.7760.3Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
115619941994.039.3439.3DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
115759821994.0255.0185.0Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
115819921992.043.3343.3The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
115919921992.051.0851.1Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
116019911991.055.7555.8Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
116179551988.8326.3481.6jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
116219881988.040.8140.8Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
116319881988.040.4140.4The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
116419881988.047.847.8Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
116519871987.054.8854.9The biology of interleukin-6. T KishimotoBlood19892473791No
116639741987.085.5142.8Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
116719861986.066.0966.1The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
116839691984.590.945.5Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
116939681984.086.3643.2The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
117019841984.041.5541.5TRP channels as cellular sensors. David E ClaphamNature200314654832No
117179341983.5229.2357.3Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
1172138841983.4306.3143.8Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
117319831983.068.6268.6The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
117439651982.590.1945.1The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
117519801980.043.2243.2Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
117619781978.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
117719761976.038.5838.6Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
117819761976.048.5448.5Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
117939511975.598.1649.1Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
118039511975.587.5843.8The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
118178991974.8192.6148.2Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
118219721972.052.752.7Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
118319721972.054.1454.1Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
118439391969.5115.8257.9Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
1185137791968.4314.8145.0Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
118639361968.0108.1754.1Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
118739351967.586.743.4Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
118819671967.091.1591.2A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
118919661966.038.8538.9DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
119019661966.061.3661.4A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
119139311965.589.1944.6Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
119219651965.049.2149.2Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
119339291964.5109.5754.8Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
119419631963.034.9134.9Signaling--2000 and beyond. T HunterCell200010647936No
119539251962.596.7948.4Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
119639211960.5116.1858.1Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
119719601960.057.8157.8Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
119819601960.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
119919601960.070.3870.4Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
120019591959.062.6662.7Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
120158731957.7191.0663.7AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
120239121956.0125.1262.6Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
1203214961954.2534.8148.6PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
120439081954.0116.5458.3Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
120519541954.0116.78116.8Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
120639041952.0139.4769.7ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
120719521952.061.2761.3Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
120819511951.041.0541.0The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
120919511951.045.8645.9The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
121039011950.5135.4867.7Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
121119501950.047.0147.0Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
121219491949.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
121338951947.565.2432.6Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
121419471947.080.2680.3Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
121519471947.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
121619461946.061.7561.8Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
121719461946.060.0560.0Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
121858361945.3107.4235.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
121919451945.062.0462.0Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
122038891944.5144.4572.2Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
122138891944.5131.8765.9PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
122219441944.044.8644.9Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
122358301943.3120.440.1Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
122419421942.037.637.6Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
122519421942.034.1134.1Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
122677651941.2495.33123.8Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
122738821941.093.947.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
122819411941.061.3461.3Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
122919411941.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
123019411941.037.037.0Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
123119411941.038.9338.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
123238811940.5130.7165.4Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
123319401940.047.7347.7Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
123419401940.077.4477.4Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
123519391939.064.4364.4Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
123619381938.041.6841.7Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
123719381938.039.7639.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
123819381938.039.3139.3The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
123919341934.060.2460.2Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
124019311931.057.4557.5Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
124119291929.055.255.2Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
124219291929.049.6449.6Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
124338571928.534.0217.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
124438561928.094.8847.4The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
124519271927.050.7250.7DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
124619261926.042.8542.9Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
124738481924.0102.8951.4Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
124819241924.041.9542.0High-speed scanning in human memory. S SternbergScience19665939936Yes
124938481924.090.0845.0Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
125038461923.0123.0261.5Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
125119211921.046.5546.5Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
125219201920.083.7183.7Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
125338391919.573.6236.8Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
125419181918.023.0923.1A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
125519181918.041.6341.6A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
125676691917.2299.1474.8A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
125719171917.047.1347.1DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
125819151915.054.8454.8The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
125919151915.033.8133.8The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
126019151915.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
126157431914.3189.0563.0Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
126219141914.040.0340.0A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
126319141914.045.6345.6The genetics of ageing. Cynthia J KenyonNature201020336132No
126476531913.2188.8247.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
126519131913.056.2156.2Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
126619131913.039.139.1Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
126719131913.041.8941.9Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
126819111911.045.2145.2The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
126919111911.046.1846.2Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
127019111911.042.1442.1The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
127119101910.063.063.0Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
127219101910.046.4446.4Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
127319101910.098.6598.7Subjective well-being. E DienerPsychol Bull19846399758No
127438181909.098.3749.2Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
127519081908.043.3143.3The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
127638111905.5130.2465.1Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
127719051905.053.3953.4Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
127838101905.084.8142.4Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
127938071903.5121.1560.6Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
128038061903.0119.7459.9Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
128119031903.043.1843.2Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
128219021902.054.7454.7In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
128338041902.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
128419001900.062.7962.8The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
128556941898.0338.8112.9Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
128637961898.0515.71257.9Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
128718971897.043.9644.0The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
128875881897.0185.6346.4Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
128918941894.016.0716.1Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
129018941894.041.2641.3The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
129118931893.052.6552.6Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
129237851892.5118.3659.2Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
129356731891.0145.3748.5Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
129437811890.5114.5157.3Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
129518901890.053.3453.3Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
129637801890.087.1343.6PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
129718901890.058.3858.4Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
129818891889.054.0854.1Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
129918891889.0123.0123.0High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
130037761888.085.0542.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
130118871887.059.8659.9Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
130218861886.045.545.5The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
130356581886.0165.1555.1Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
130418861886.064.864.8Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
130537671883.5106.7853.4Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
130637661883.0117.5158.8An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
130737611880.589.6644.8The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
1308150411880.1367.746.0Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
130918791879.069.0669.1Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
131018791879.0111.75111.8Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
131175131878.2253.3563.3Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
131218771877.041.1841.2Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
131337531876.586.1343.1The Fas death factor. S Nagata, P GolsteinScience19957533326No
131437521876.0129.0664.5Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
131518751875.060.3160.3The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
131618741874.078.8578.8The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
131718731873.091.0491.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
131818731873.050.8350.8Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
131956181872.7196.7665.6Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
132074851871.2181.1245.3Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
132137421871.0125.8462.9Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
132218701870.039.9640.0Exploring complex networks. S H StrogatzNature200111258382No
132318701870.049.6449.6Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
132418691869.068.468.4Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
132518691869.051.0251.0A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
132656051868.3151.3450.4trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
132737361868.068.134.0Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
132818681868.069.2169.2Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
132956021867.3125.4941.8A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
133055961865.3455.38151.8An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
133137291864.578.5139.3Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
133218631863.042.0242.0Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
133393121862.4221.4544.3Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
133418621862.073.2573.2Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
1335130301861.4465.2366.5Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
133618611861.041.541.5Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
133737201860.078.7939.4Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
133818591859.048.8648.9Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
133918581858.052.3652.4Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
134018581858.037.3437.3Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
134118571857.060.0960.1Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
134218561856.038.7738.8Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
134318561856.058.3958.4Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
134418551855.043.8543.9The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
134518541854.047.647.6From sensation to cognition. M M MesulamBrain19989648540No
134618541854.041.6441.6Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
134718531853.045.2945.3Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
134818531853.048.5548.5Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
134937051852.5102.9851.5EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
135037041852.076.7738.4Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
135136991849.576.8238.4Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
135255451848.3139.0446.3Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
135318461846.048.5648.6The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
1354147651845.6414.6851.8Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
135573791844.8178.6244.7Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
135655221840.7122.1540.7Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
135736801840.056.8228.4Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
135818401840.045.1745.2Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
135936781839.081.9941.0Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
136018391839.055.7355.7The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
136118391839.084.5484.5Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
136218381838.052.5852.6Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
136373491837.2339.8885.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
136436741837.0120.6660.3Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
136518371837.041.4541.5DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
136618371837.043.9343.9Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
136736741837.0129.9765.0miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
136836731836.599.6849.8Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
136918351835.068.268.2Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
137036691834.5110.2155.1New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
137136671833.5133.1666.6The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
137236661833.0131.7765.9Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
137336651832.576.3938.2Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
137454971832.3120.6840.2A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
137518321832.035.4335.4Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
137618291829.045.1445.1A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
137718291829.066.1966.2Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
137818291829.054.254.2An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
137918291829.022.8722.9A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
138018291829.036.3436.3MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
138136571828.5104.9952.5Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
138236571828.5150.9575.5mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
138318281828.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
138418281828.049.9149.9Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
138573081827.0203.2850.8Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
138618271827.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
138736531826.589.1144.6Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
138836511825.5141.5770.8ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
138918251825.049.6449.6Protein denaturation. C TanfordAdv Protein Chem19684882248No
139018251825.036.7736.8Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
139136431821.5340.72170.4WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
139218211821.040.4240.4Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
1393145631820.4606.6475.8The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
139418201820.070.0570.0Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
1395109041817.3318.2553.0Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
139636291814.5154.1777.1Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
139718141814.049.4649.5Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
139818141814.039.8939.9Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
139936221811.092.8446.4Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
140018091809.055.0955.1Social relationships and health. Sheldon CohenAm Psychol200415554821No
140154261808.7102.8234.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
140218081808.056.7756.8The inverse care law. J T HartLancet19714100731Yes
140318071807.058.8958.9Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
140418071807.050.6850.7Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
140536141807.087.443.7Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
140618051805.046.2846.3Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
140718021802.066.3466.3The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
140836021801.0100.9650.5Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
140918001800.042.5342.5Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
141018001800.049.9149.9Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
141153961798.7112.4637.5A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
141289921798.4234.947.0Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
141317971797.056.5356.5Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
141417971797.044.8144.8Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
141553881796.0164.9955.0Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
141617961796.048.7548.8Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141717951795.062.462.4A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
141817951795.075.7775.8Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
141935891794.592.2846.1Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
142017941794.048.3648.4New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
142117941794.042.4342.4Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
142217941794.035.8235.8The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
142317941794.053.0753.1Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
142417921792.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
142553751791.7141.7347.2Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
142617911791.0102.74102.7Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
142717911791.036.736.7Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
142817901790.047.847.8What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
142971601790.0273.0968.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
143035791789.5159.5979.8Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
143117891789.036.1636.2Points of control in inflammation. Carl NathanNature200212490957No
143217891789.043.943.9Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
143335761788.085.9843.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
143417881788.059.1159.1Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
143535761788.0122.7561.4The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
143635751787.5180.3390.2Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
143735741787.0115.7657.9Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
143817861786.058.3458.3The crisis in antibiotic resistance. H C NeuScience19921509257No
143917841784.054.8554.9Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
144035681784.086.1843.1Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
144117841784.052.2952.3phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
144235621781.098.7849.4The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
144335611780.5125.7462.9The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
144417791779.042.7442.7Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
144535581779.0110.0755.0Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
144635571778.5250.09125.0Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
144735551777.587.6743.8Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
144817761776.032.7632.8Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
144971021775.5138.0334.5Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
145017751775.036.7836.8Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
145117741774.018.4918.5Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
145217741774.038.738.7The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
145317741774.059.2759.3Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
145453201773.3140.3846.8The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
145517731773.057.8957.9Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
145617731773.036.2336.2An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
145717731773.036.1836.2Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
145817701770.058.758.7Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
145917701770.046.4146.4Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
1460123831769.0299.5442.8Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
146135371768.5109.7854.9Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
146235371768.588.5644.3The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
146335371768.582.3241.2The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
146417671767.046.4246.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
146517641764.046.946.9Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
146617641764.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
146717641764.070.9370.9Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
146817631763.039.1339.1Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
1469176271762.7553.8955.4Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
1470105731762.2317.452.9New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
147117621762.060.5360.5Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
147217611761.055.4555.5The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
147317591759.051.2251.2Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
147417591759.047.6747.7G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
147535181759.074.7237.4Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
147617591759.042.4142.4Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
147735181759.0127.7163.9The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
147835141757.086.5343.3Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
147935131756.545.6622.8A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
148035131756.573.1136.6Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
148117551755.041.1841.2Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
148217551755.035.7835.8Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
148317541754.040.1540.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
148417541754.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
148535051752.579.3639.7Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
148652571752.3221.4973.8The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
148717521752.065.5865.6Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
148887601752.0292.2958.5The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
148917511751.061.2161.2The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
149035011750.599.6549.8Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
149117481748.038.6138.6The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
149234951747.592.846.4Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
149334951747.5136.7668.4Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
149417471747.042.2842.3Why genes in pieces? W GilbertNature1978622185Yes
149517471747.043.5543.5Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
149617471747.047.1247.1Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
149717461746.044.4544.5The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
149817461746.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
149917461746.041.5741.6Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
150017451745.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
150134891744.569.6934.8A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
150217441744.038.638.6ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
150334861743.082.6741.3Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
150417421742.065.4665.5Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
150534821741.092.1446.1The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
150634811740.5156.4678.2The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
150734791739.573.0136.5Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
150817391739.041.4141.4The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
150917391739.071.7171.7Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
151052161738.7117.9139.3Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
151169511737.8136.0934.0Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
151234741737.068.8734.4An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
151317361736.057.0157.0Serum albumin. T PetersAdv Protein Chem19853904348No
151417361736.073.4273.4Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
151517361736.056.3256.3Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
151617361736.032.7832.8Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
151769401735.0293.1273.3An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
151834691734.5138.7569.4Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
151934691734.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
152017341734.062.6162.6Cyclosporine. B D KahanN Engl J Med19892687689No
152117341734.040.6240.6Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
152217341734.052.5152.5Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
152317331733.054.4254.4Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
152417331733.065.9265.9Selenium and human health. Margaret P RaymanLancet201222381456No
152534651732.594.347.1Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
152634651732.5178.4689.2Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
152717321732.050.0250.0Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
152817321732.0109.91109.9The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
152934631731.5149.8274.9A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
153034631731.590.8345.4Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
153134631731.5103.6851.8The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
153217311731.040.6340.6Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
153351931731.0112.6937.6Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
153417311731.033.533.5Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
153517291729.059.4859.5Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
153634581729.095.0347.5Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
153717281728.036.536.5Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
153817281728.039.3339.3Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
153917271727.060.8260.8Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
154017271727.041.9241.9Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
154134521726.074.2537.1Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
1542120781725.4404.9457.8GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
154317241724.031.2331.2CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
154451671722.3133.3944.5The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
154517221722.065.1665.2Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
154686081721.6196.2339.2Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
154717211721.058.4758.5Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
154834421721.0131.4365.7The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
154951621720.7231.6577.2Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
155017201720.056.0756.1The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
155134401720.088.8444.4Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
155234381719.086.6443.3Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
155317191719.038.7138.7Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
155417171717.037.5637.6AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
155585841716.8212.1942.4Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
155651461715.3161.7553.9Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
155717151715.056.6656.7Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
155817151715.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
155985751715.0323.864.8UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
156034301715.0132.1166.1The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
156117141714.045.4345.4THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
156234271713.586.6143.3Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
156317131713.059.3659.4Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
156417131713.036.9637.0Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
156517131713.056.7456.7Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
156617121712.042.0742.1The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
156717121712.044.5344.5Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
156851331711.0134.044.7A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
156934211710.586.4843.2Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
157017101710.038.6438.6Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
157117101710.031.6331.6Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
157234181709.082.1341.1The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
157334171708.569.0134.5A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
157434131706.5153.1276.6A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
157517061706.033.4833.5The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
1576170531705.3541.6454.2The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
157717051705.031.4431.4How eukaryotic transcriptional activators work. M PtashneNature19883050531No
157817051705.032.7532.8Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
157917041704.068.0168.0Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
158068141703.5143.0835.8Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
158168131703.2195.7648.9The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
158217031703.052.2852.3A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
158317031703.051.1651.2Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
158434061703.0121.8960.9A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
158534061703.088.3644.2Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
158634051702.5109.6154.8Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
158717011701.076.7876.8The micronucleus test. W SchmidMutat Res197548190Yes
158851021700.7120.2840.1Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
158968011700.2223.8756.0Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
159017001700.038.4338.4Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
159134001700.095.8347.9Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
159250981699.3112.137.4An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
159316991699.042.6142.6The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
1594135911698.9393.3449.2The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
159516981698.068.6268.6Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
159633961698.078.4239.2The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
1597101821697.0285.1647.5Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
159816971697.039.6239.6Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
159916961696.043.7443.7Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
160016951695.036.1136.1Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
160150831694.3166.5555.5A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
160216941694.039.9439.9A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
160333881694.093.8146.9Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
160416941694.034.4234.4Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
160516941694.046.2646.3The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
160633871693.5102.2451.1The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
160750781692.7152.9651.0Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
160816921692.063.3963.4Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
160916911691.069.5869.6Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
161016911691.045.3345.3Integrins. E RuoslahtiJ Clin Invest19911985087No
161116911691.031.1531.1Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
161233801690.0158.7379.4Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
161333791689.580.8940.4CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
161416891689.038.8738.9PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
161533741687.0221.13110.6The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
161616871687.040.5340.5The molecular genetics of cancer. J M BishopScience19873541204No
161716871687.040.0140.0Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
161816871687.036.7936.8Perceptions of epigenetics. Adrian BirdNature200717522671Yes
161967461686.5194.6748.7Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
162016861686.036.536.5The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
162116851685.054.4954.5Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
162216851685.051.4251.4Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
162316841684.047.2947.3The in vitro micronucleus technique. M FenechMutat Res200011113469No
162416841684.039.1539.1A revolution in optical manipulation. David G GrierNature200312917694No
162516841684.027.9227.9Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
162650511683.7109.1236.4Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
162733661683.083.3641.7Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
162816831683.051.8251.8Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
162933641682.098.7449.4An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
163050461682.0182.1460.7Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
163133641682.0111.7255.9Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
163233631681.5107.5553.8Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
163316811681.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
163416811681.052.9753.0Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
163516801680.019.2719.3Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
163667201680.0223.3155.8SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
163716791679.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
163833571678.578.5739.3Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
163983911678.2112.5422.5Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
164033561678.083.3841.7Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
164167081677.0265.2166.316S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
164216771677.049.1149.1Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
164333541677.069.8334.9A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
164416771677.068.7868.8Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
164533531676.5110.4855.2Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
164616761676.058.3958.4Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
164716761676.032.8332.8Hox genes in vertebrate development. R KrumlaufCell19947913880No
164816761676.038.5638.6NADPH oxidase: an update. B M BabiorBlood199910029572No
164916761676.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
165033511675.5124.9962.5The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
165133491674.571.2835.6The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
165216741674.031.0731.1Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
165316741674.044.4844.5Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
165416731673.045.3745.4Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
165533451672.579.2139.6The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
165633451672.590.7345.4Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
165716721672.038.3938.4The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
165816701670.059.4359.4Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
165916701670.050.0650.1Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
166066791669.8205.2151.3The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
166133381669.053.6926.8Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
166216691669.037.2137.2Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
166333381669.091.9746.0A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
1664100131668.8204.6134.1Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
166533371668.5134.1967.1Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
166616681668.032.4232.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
166716681668.019.0719.1Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
166850021667.3263.4787.8Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
166916671667.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
167016661666.039.5539.5The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
167116661666.053.5753.6The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
167249961665.3197.3565.8The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
167316651665.081.9481.9Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
167416651665.063.4863.5Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
167516651665.052.7552.8Metallothionein. D H HamerAnnu Rev Biochem19863527054No
167616651665.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
167716651665.046.8246.8The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
167816641664.055.0355.0Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
167916641664.030.7830.8Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
168016631663.039.7839.8Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
168116631663.040.8240.8Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
168216631663.042.5742.6Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
168316631663.046.7346.7Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
168416621662.019.9219.9Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
168516611661.067.7867.8A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
168616611661.035.8235.8Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
168716611661.060.5760.6Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
168816581658.031.9431.9Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
168916571657.045.5645.6An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
169016571657.059.4159.4Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
169133121656.083.2141.6Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
169216561656.033.433.4DNA in a material world. Nadrian C SeemanNature200312540916No
169316561656.045.9345.9Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
169416561656.046.9747.0Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
1695115911655.9343.5549.1AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
169633101655.060.3630.2Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
169716551655.031.2231.2Switching and signaling at the telomere. E H BlackburnCell200111572773No
169816551655.038.8738.9Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
169916551655.081.081.0Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
170033091654.5131.5765.8The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
170116541654.023.9223.9RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
170233081654.068.9534.5Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
170333081654.078.0939.0Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
170433071653.5127.2563.6A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
170566131653.2152.4938.1Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
170633051652.5214.58107.3A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
170733051652.566.7333.4Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
170816521652.035.6235.6An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
170916521652.057.7757.8Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
171016511651.041.8941.9The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
171116501650.041.7941.8Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
171216501650.050.2450.2Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
171332981649.066.233.1Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
171416471647.037.5837.6In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
171532941647.075.1637.6Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
171616471647.045.8645.9Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
171716461646.042.7142.7Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
171816441644.046.8446.8The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
171932881644.086.5543.3Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
172065751643.8286.3371.6A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
172116431643.048.8148.8Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
172216431643.073.3773.4The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
172316421642.053.9453.9Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
172432841642.071.3435.7Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
172532831641.585.6442.8Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
172632831641.5137.0268.5Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
172716411641.048.648.6Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
172816411641.045.3845.4Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
172916401640.034.7934.8Neuronal calcium signaling. M J BerridgeNeuron19989697848No
173016401640.0206.31206.3COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
173198341639.0227.9238.0Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
173232781639.083.2441.6ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
173316371637.057.9958.0The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
173432741637.0155.3377.7Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
173516351635.049.6549.6Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
173616341634.072.6772.7Mood and memory. G H BowerAm Psychol19817224324Yes
173716341634.056.5556.5Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
173816341634.029.1529.1Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
173916341634.040.4440.4A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
174032661633.063.731.9The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
1741179441631.3562.9851.2A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
174216311631.040.1340.1Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
174332611630.5116.2258.1Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
174416301630.071.0671.1Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
174516301630.056.5356.5The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
174632601630.068.0534.0The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
174748891629.7116.1138.7Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
174816291629.033.233.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
174916291629.034.6934.7Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
175048831627.795.1531.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
175116271627.040.8140.8External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
175216261626.057.1857.2The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
175316261626.058.0458.0Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
175416261626.058.4658.5Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
175516261626.042.5542.5Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
175616251625.045.7645.8Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
175716251625.042.442.4Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
175816241624.050.8650.9Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
175997401623.3338.6956.4Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
176016221622.046.3546.4Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
176116221622.053.2153.2The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
176216221622.066.9466.9Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
176316201620.056.6956.7Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
176416201620.0125.87125.9User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
176516191619.047.4147.4Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
176632371618.576.9638.5Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
176716181618.030.2530.2Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
176816181618.030.5730.6Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
176932351617.589.244.6Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
177016161616.027.5227.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
177132311615.596.4148.2Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
177216151615.036.836.8Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
177316141614.049.0549.0Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
177416141614.052.9653.0Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
177516131613.049.6149.6Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
177616121612.045.6445.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
177716121612.033.9534.0The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
177816111611.039.8439.8Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
177916101610.039.4339.4Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
178016101610.036.936.9Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
178116091609.052.3352.3Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
178216091609.051.2551.2Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
178316081608.036.6936.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
178416081608.030.9631.0The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
178516071607.040.4140.4The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
178616061606.076.2276.2Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
178732101605.0172.0186.0Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
178832081604.094.647.3Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
178916041604.031.5531.6Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
179048091603.0101.4233.8Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
179132061603.097.8748.9Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
179232051602.562.2331.1Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
179316021602.072.772.7Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
179432041602.066.2433.1Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
179516011601.036.8636.9VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
179632021601.0113.5656.8Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
179716011601.039.139.1The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
179816011601.044.344.3Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
179916011601.037.8737.9The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
180016001600.034.5534.5On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
180116001600.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
180231991599.561.7230.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
180315991599.036.2136.2Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
180415991599.055.8855.9Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
180515991599.037.0137.0A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
180615991599.045.0145.0Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
180731971598.597.8148.9How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
180815981598.071.4471.4The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
180915981598.030.630.6The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
181015981598.042.1642.2Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
181115971597.040.8640.9Molecular biology of prion diseases. S B PrusinerScience19911675487No
181231941597.083.1141.6Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
181315971597.048.0748.1Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
181415961596.031.5531.6An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
181515961596.028.8828.9Altering the genome by homologous recombination. M R CapecchiScience19892660260No
181631921596.067.5433.8Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
181715961596.035.7935.8Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
181815961596.047.2747.3A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
181931921596.0124.4762.2Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
182015961596.074.6774.7Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
182131921596.0100.6150.3Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
182215951595.045.6745.7The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
182331891594.562.1531.1The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
182431891594.570.9535.5Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
182515941594.057.2757.3Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
182631881594.089.244.6Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
182715931593.048.8648.9The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
182815931593.039.439.4Tumor necrosis factor (TNF). L J OldScience19852413547Yes
182931861593.088.044.0Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
183015931593.036.8236.8Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
183131841592.077.7538.9A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
183231821591.0103.0551.5The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
183331811590.565.1732.6Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
183431801590.062.5831.3NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
183563591589.8216.2154.1Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
183631791589.599.649.8Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
183731791589.569.0134.5Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
183815891589.035.8335.8Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
183931761588.091.5545.8Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
184015881588.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
184147621587.3115.9638.7Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
184215871587.023.123.1Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
184315861586.034.2134.2Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
184415851585.052.2852.3Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
184515851585.034.3734.4Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
184615851585.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
184747541584.7130.443.5Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
184831691584.592.4746.2Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
184915841584.049.5449.5Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
185031681584.076.1438.1Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
185115831583.079.4579.5Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
185215831583.042.0442.0A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
185315831583.040.3140.3Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
185415831583.031.0731.1Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
185515831583.035.5635.6The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
185615831583.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
185715821582.029.8629.9Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
185815821582.052.3252.3Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
185931621581.096.9248.5Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
186015811581.048.448.4Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
186115811581.030.4230.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
186247421580.7115.638.5Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
186315801580.0110.21110.2Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
186415791579.035.4835.5The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
186531581579.099.2749.6Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
186615791579.062.4862.5α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
186715791579.063.4663.5Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
186831571578.558.0829.0The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
186931561578.074.9737.5Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
187015761576.029.3429.3How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
187115761576.029.8829.9Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
187215761576.035.9836.0Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
187394531575.5222.9137.2GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
187463021575.5154.6538.7Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
187515751575.046.0246.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
187615751575.042.7242.7The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
187715741574.065.4765.5Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
187815741574.052.7652.8Biology of interleukin 1. C A DinarelloFASEB J19883277884No
187915741574.037.337.3The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
188015741574.076.876.8International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
188131471573.568.0934.0Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
188215731573.029.8629.9Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
188331451572.567.1633.6Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
188447171572.3121.9640.7Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
188515721572.044.9444.9Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
188615721572.033.4533.5From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
188715711571.041.6241.6Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
188831421571.070.2535.1The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
188931421571.067.2133.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
189015701570.026.0526.1Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
189115701570.037.8537.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
189215701570.059.7159.7A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
189315691569.027.8327.8Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
189415691569.037.6837.7HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
189531381569.060.5430.3Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
189615691569.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
189715691569.033.3633.4Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
189815681568.059.7659.8Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
189931351567.5101.2450.6The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
190015671567.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
190131311565.574.037.0Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
190246961565.387.5729.2Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
190331301565.079.3539.7Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
190431291564.565.5232.8Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
190531251562.5116.4758.2Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
190631251562.575.7437.9Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
190731251562.592.8446.4Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
190831251562.5140.2870.1MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
190946851561.792.9431.0Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
191093671561.2264.7744.1A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
191131221561.063.9332.0'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
191215611561.031.1231.1The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
191315601560.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
191431171558.5109.3454.7The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
191515571557.077.5677.6Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
191615571557.036.4236.4The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
191746671555.7130.1643.4Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
1918155571555.7370.4137.0Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
191931101555.058.629.3Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
192015551555.031.2631.3The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
192131101555.066.4433.2Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
192215541554.061.2561.2A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
192315541554.038.2938.3Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
192415531553.048.0848.1The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
192546591553.0272.9191.0SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
192631051552.590.2745.1Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
192746571552.3103.6434.5Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
192846571552.3104.434.8Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
192915521552.036.2136.2Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
193015511551.048.2448.2Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
193115511551.035.0535.0Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
193231021551.061.9431.0Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
193315511551.033.433.4The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
193415501550.041.8541.9Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
193530991549.5106.3953.2Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
193630991549.540.1620.1Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
193746481549.3155.9252.0Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
193846431547.788.5729.5A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
193915471547.037.0137.0Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
194030931546.588.0444.0Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
194115461546.042.342.3Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
194215461546.042.5242.5Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
194330911545.581.240.6The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
194430901545.071.1835.6A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
194515451545.043.7843.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
194615451545.048.748.7The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
194730881544.094.047.0LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
194815431543.032.1932.2Drug discovery: a historical perspective. J DrewsScience200010720314No
194930861543.062.9231.5Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
195015431543.030.930.9RNA silencing in plants. David BaulcombeNature200415372043No
195115431543.051.3651.4Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
195277061541.2152.3430.5Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
195315411541.028.6128.6Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
195415411541.043.4443.4Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
195530811540.562.0831.0The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
195630801540.0182.0591.0Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
195730791539.579.239.6Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
195830791539.556.6528.3Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
195961571539.2120.2230.1A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
1960107741539.1299.7142.8BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
196130761538.0183.5391.8A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
196215381538.055.3455.3Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
196315381538.030.3130.3E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
196430761538.063.4831.7Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
196515381538.041.9441.9n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
196615381538.051.3351.3A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
196730751537.571.4435.7New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
196830741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
196930731536.568.5334.3The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
197030731536.5115.6857.8Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
197130721536.079.4939.7Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
197215361536.045.4645.5Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
197346071535.7117.4139.1Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
197430711535.576.5638.3Obesity. David W Haslam, W Philip T JamesLancet200516198769No
197515341534.029.8329.8Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
197615341534.043.4943.5Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
197715331533.056.1956.2Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
197845991533.0121.1240.4Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
197915331533.059.0359.0Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
198030651532.567.6433.8Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
198130651532.5103.8451.9Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
198245941531.399.533.2Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
198315311531.042.6842.7Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
198415301530.045.8345.8Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
198515301530.059.4559.5MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
198615291529.048.6948.7Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
198730581529.067.6433.8NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
198815281528.041.3341.3Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
198915281528.022.2222.2An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
199015281528.030.5930.6Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
199115271527.033.7333.7Molecular themes in oncogenesis. J M BishopCell19911988146No
199291621527.0282.9947.2TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
199345801526.7129.143.0The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
199415261526.038.9138.9Early signals in the mitogenic response. E RozengurtScience19863018928No
199530511525.571.0835.5Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
199615251525.037.9838.0Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
199715251525.033.3733.4Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
199815251525.066.4266.4Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
199930491524.579.1739.6Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
200015241524.045.8145.8Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
200115241524.050.3950.4Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
200215241524.033.733.7Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
2003182841523.7752.1262.7Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L RehmGenet Med201525741868No
200415231523.043.5243.5Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
200515221522.046.1146.1Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
200615221522.035.5735.6Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Bei-Fan ZhouBiomed Environ Sci200212046553Yes
200715221522.034.634.6Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
200830441522.080.0140.0Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
200945601520.096.7332.2The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
201015201520.043.4443.4Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
201130391519.587.4243.7What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
201230391519.5127.3163.7Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
201315191519.090.5190.5Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
201415191519.032.6932.7Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
2015136671518.6421.4246.8The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
201615181518.018.3218.3A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
201715181518.042.0942.1Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
201845531517.7110.9137.0Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
201915171517.028.0528.1Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
202015171517.049.1749.2The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
202145501516.7117.4339.1How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
202230331516.5118.6759.3Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
202315161516.055.7655.8Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
202415161516.038.0438.0Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
202530321516.0102.3751.2Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
202630321516.030.6215.3Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
202715161516.031.7431.7Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
202815161516.037.4737.5Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
202930301515.093.3146.7Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
203090881514.7213.0135.5Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
203115141514.040.5640.6Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
203215131513.050.1950.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
203315121512.039.5839.6The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
203415121512.032.9833.0Far-field optical nanoscopy. Stefan W HellScience200717525330No
203530231511.565.6232.8Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
203615081508.066.4966.5Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
203715081508.049.8349.8The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
203815081508.037.9838.0Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
203915081508.033.133.1Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
204030161508.066.9333.5ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
204130161508.082.5341.3Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
2042165791507.2434.1539.5The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
204315071507.048.248.2Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
204445201506.7228.276.1Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
204515061506.046.8346.8The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
204645161505.3156.6152.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
204730091504.590.1445.1Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
204845131504.3162.254.1Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
204915041504.033.5933.6The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
205030081504.088.9444.5Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
205145121504.0120.4340.1I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
205230061503.059.129.6Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
205330051502.5147.5273.8A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
205415011501.048.2148.2Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
205515001500.040.7540.8Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
205615001500.048.2348.2SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
2057194891499.2505.2338.9Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
205814981498.024.7924.8Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
205929951497.566.3433.2How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
206014971497.051.8151.8Lyme disease. A C SteereN Engl J Med19892668764No
206114971497.042.2642.3The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
206214961496.047.7647.8Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
206314961496.042.1942.2Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
206414951495.035.4535.5Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
206514951495.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
206614941494.033.6333.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
206714941494.032.7232.7The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
206829881494.076.138.0Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
206929861493.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
207029851492.587.2943.6The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
207114921492.033.1933.2Tumor suppressor genes. R A WeinbergScience19911659741No
207214921492.026.2926.3R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
207314921492.046.5146.5Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
2074104441492.0222.7831.8Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
207514921492.072.0672.1Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
207614921492.036.9937.0An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
207729831491.564.232.1Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
207829821491.061.5530.8Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
207944721490.761.2320.4Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
208029811490.559.9330.0Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
208114901490.026.126.1Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
208229801490.099.3449.7How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
208314901490.031.4331.4Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
208429791489.557.0728.5Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
208529781489.086.7143.4Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
208614891489.031.8331.8Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
208714881488.050.9450.9Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
208829761488.071.3135.7Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
208914871487.034.0734.1Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
209014871487.043.0743.1Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
209114861486.039.1739.2The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
209214861486.027.3927.4Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
209314861486.036.3336.3Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
209414861486.057.5857.6AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
209529691484.5111.7755.9Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
209614841484.019.8419.8Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
209714841484.062.9563.0Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
209814831483.018.3618.4The mechanism of muscular contraction. H E HuxleyScience19694181952No
209914831483.033.2933.3Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
210044471482.3685.03228.3MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
210114811481.043.2143.2The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
210244421480.779.0126.3Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
210344411480.393.5431.2TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
210429601480.072.7336.4Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
210559181479.5129.2332.3Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
210614791479.030.4330.4Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
210714781478.054.7654.8Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
210814781478.039.4839.5Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
210959111477.8246.2961.6A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
211088661477.7259.8343.3Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
211114771477.036.2836.3Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
211214771477.040.1740.2Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
211344291476.357.319.1The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
211414761476.033.833.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
211514761476.012.4512.4Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
211614761476.036.7936.8Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
211714751475.045.4845.5Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
211829501475.086.9643.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
211914741474.045.9946.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
212014741474.058.5658.6An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
212114731473.043.3543.4Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
212214731473.076.3476.3The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
212344191473.0110.8637.0The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
212429441472.081.640.8A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
2125132441471.6626.3769.6Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
212629431471.576.5538.3The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
212714711471.040.2540.2Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
212844081469.3160.5353.5Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
2129132231469.2408.7245.4The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
213044071469.0133.9144.6Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
213114691469.033.9934.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
213214681468.036.636.6Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
213314681468.039.4739.5A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
213429351467.591.6645.8Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
213514671467.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
213614671467.059.4759.5Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
213729311465.574.137.0Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
213843951465.095.5931.9Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
213914651465.034.434.4Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
214014651465.038.3138.3Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
214114641464.033.8833.9PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
214229281464.0108.0554.0A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
214387751462.5258.8243.1The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeLancet200718064739Yes
214414621462.029.9229.9The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
214514621462.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
214629231461.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
214714611461.040.9641.0Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
214829221461.077.7238.9Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
214929221461.0113.4456.7Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
215014601460.036.4836.5Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
215114601460.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
215214601460.042.7642.8Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
215314601460.044.0544.0The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
215414601460.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
215514601460.031.7831.8Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
215629181459.067.6733.8The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
215729171458.557.9929.0Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
215814581458.034.4634.5Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
215914581458.094.1494.1The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
216014581458.032.9733.0Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
216114581458.031.7531.8DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
216214581458.050.8650.9Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
216314581458.058.9158.9The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
216429151457.597.8848.9Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
216514571457.018.9619.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
216614571457.041.7541.8Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
216743681456.085.528.5The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
216814561456.014.9915.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
216914551455.056.956.9Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217029101455.074.6237.3The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
217114541454.050.7950.8The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
217214541454.031.6131.6Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
217314541454.035.5635.6The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
217429081454.073.5836.8Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
217514531453.047.4347.4A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
217614531453.033.0333.0Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
217729061453.0119.6759.83D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
217829051452.5103.9152.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
217914521452.028.7728.8The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
218014521452.064.8264.8Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
218143551451.7125.7541.9Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallières, C M. MorinSleep Med200111438246Yes
218243541451.3101.3833.8Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
218314511451.057.7357.7Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
218414511451.036.836.8Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
218529001450.073.3536.7A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
218614501450.034.7134.7Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
218729001450.088.2944.1CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
218828991449.574.5537.3Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
218928991449.579.4739.7A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
2190115951449.4288.3336.0Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
219114491449.035.6535.6General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
219214491449.029.5829.6Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
219314481448.048.7248.7Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
219414481448.040.1840.2Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
219557901447.5164.341.1The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
219643421447.392.7230.9NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
219728941447.075.7237.93' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
219814471447.033.6233.6Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
219928941447.066.3533.2Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
220028931446.592.7946.4Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
220114461446.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
220228911445.594.6947.3The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
220328911445.561.8730.9A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
220428891444.560.1930.1The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
220514441444.030.2630.3Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
220614431443.035.835.8The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
220714431443.037.9337.9Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
220814431443.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
220957721443.0146.5836.6Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
221028851442.575.7437.9Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
221128851442.5197.798.8ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
221214421442.042.1142.1Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
221328831441.586.043.0The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
221428831441.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
221543221440.7217.2772.4Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graça RaposoNat Rev Mol Cell Biol201829339798No
221657611440.2210.3552.6FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
221728801440.078.3539.2Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
221814401440.036.6636.7The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
221914401440.040.7540.8Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
222014381438.050.1150.1Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
222128751437.567.5333.8Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
222214371437.042.8642.9The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
222328731436.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
222414361436.037.0537.0Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
222514361436.048.1148.1Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
222614351435.094.3694.4The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
222714351435.021.4921.5Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
222828691434.557.128.6Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
222914341434.043.7343.7Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
223028681434.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
223128671433.555.327.6Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
223257331433.2168.0442.0Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
223314321432.042.6142.6Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
223414321432.044.8644.9Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
223528621431.053.826.9T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
223671511430.2154.3930.9Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
223714301430.060.4460.4The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
223814301430.033.7733.8Proinflammatory cytokines. C A DinarelloChest200010936147No
223928591429.573.0936.5Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
224014291429.035.6435.6The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
224128581429.098.2149.1The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
224214291429.053.4653.5Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
224314291429.049.1449.1Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
224442861428.786.4828.8Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
224528571428.5101.050.5Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
224614271427.043.2743.3Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
224714271427.041.1341.1The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
224842811427.088.1329.4Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
224914271427.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
225014271427.027.2527.2The significance of responses of the genome to challenge. B McClintockScience198415739260No
225114271427.040.6840.7Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
225228521426.070.1335.1Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
225314261426.050.9851.0Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
225457041426.0258.9564.7Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
225528511425.585.9543.0An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
225642761425.3122.140.7Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
225714251425.037.2737.3The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
225814251425.033.8433.8The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
225914241424.044.2844.3Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
226014231423.025.6725.7The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
226114231423.040.9841.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
226228451422.554.9227.5Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
226314211421.039.7739.8Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
226414211421.026.6226.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
226514201420.051.8551.9Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
226614201420.033.3333.3Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
226728371418.579.2839.6Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
226828361418.084.2342.1Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
226914181418.037.6837.7A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
227028351417.555.0327.5Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
227156671416.8155.3438.8Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
227214161416.039.1339.1The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
227328321416.081.6640.8CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
227414151415.034.3934.4Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
227542441414.7139.8946.6Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
227614141414.044.3444.3The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
227728271413.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
227814131413.024.4924.5The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
227928261413.089.6944.8Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
228028261413.082.3941.2Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
228184741412.3217.0736.2Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228242341411.3147.9749.3Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
228328221411.088.544.2Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
228414111411.061.461.4Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
228514101410.050.8150.8The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
228628201410.086.2143.1Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
228714101410.035.4335.4Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
228814101410.035.5835.6Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
228914101410.026.3126.3A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
229014101410.039.7239.7BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
229128191409.552.326.1Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
229284551409.2277.3246.2Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
229314091409.046.0146.0Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
229414091409.063.3263.3Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
229514091409.034.6834.7The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
229628161408.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
229742221407.3101.033.7Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
229842211407.0143.8347.9Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
229914071407.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
230014071407.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
230128121406.062.2931.1The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
230228111405.581.0540.5Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
230328081404.089.1744.6The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
230414041404.032.8132.8Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
230528081404.069.8934.9Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
230642111403.793.5531.2OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
230728071403.576.9938.5Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
230814031403.025.1925.2Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
230914031403.033.4233.4The basic science of gene therapy. R C MulliganScience19938493530No
231028051402.570.9935.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
231128041402.069.9535.0Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
231228031401.562.4531.2Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
231314011401.026.1726.2NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
231428011400.542.0321.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
231528001400.072.0936.0EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
231627991399.5147.2273.6Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
231713981398.030.6130.6The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
231813981398.031.5431.5The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
231913971397.040.540.5Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
232013971397.036.236.2Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
232113971397.064.3664.4PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
232227931396.582.4341.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
232313961396.029.129.1Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
232413961396.031.9632.0Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
232527921396.061.5330.8An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
232613961396.029.6529.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
232727921396.065.9733.0Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
232813961396.034.7834.8Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
232913951395.033.8733.9Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
233013941394.052.9753.0Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
233113941394.044.1244.1Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
233213941394.030.2630.3Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
233313941394.029.5329.5A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
233441791393.0196.4365.5Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
233513931393.050.250.2Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
233613931393.017.3617.4Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
233713931393.033.2933.3Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
233827851392.570.5835.3Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
233913921392.026.9927.0Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
234013921392.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
234113921392.062.8362.8Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
234241741391.3106.0735.4Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
234327821391.083.3741.7Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
234427821391.067.3633.7Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
234569531390.6257.0651.4Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
234641691389.7111.4437.1TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
234727791389.574.4137.2Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
234827791389.568.5434.3Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
234941681389.3135.9645.3Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
235013891389.024.4524.4The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
235141661388.787.8229.3Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
235241631387.783.9328.0The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
235313871387.032.1132.1Huntington's disease. Francis O WalkerLancet200717240289No
235455481387.0210.6852.7Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
235527731386.5108.5154.3Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
235613861386.035.4835.5The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
235727701385.071.6435.8A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
235827681384.0100.7850.4Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
235941511383.798.8532.9Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
236027661383.080.0440.0Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
236127661383.061.4130.7Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
236269111382.2200.2840.1Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
236313821382.030.7830.8Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
236413821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
236527641382.098.6949.3Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
236627631381.561.330.6A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
236713811381.0131.41131.4A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
236813801380.050.4850.5The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
236927601380.054.7827.4Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
237013801380.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
237127581379.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
237213781378.031.0231.0Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
237313771377.051.8951.9Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
237413771377.043.5843.6The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
237513771377.044.0144.0Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
237613761376.059.3359.3Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
237713761376.042.9342.9The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
237813761376.032.2932.3Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
237913761376.039.2339.2Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
238027511375.50.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
238127501375.094.3647.2Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
238213751375.034.1934.2The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
238327501375.070.5835.3Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
238427471373.50.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
238513731373.025.9826.0Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
238627441372.063.3131.7Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
238727441372.073.4936.7Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
238813721372.037.4537.5The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
238927431371.577.3738.7Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
239027411370.558.0429.0LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
239113701370.028.4228.4Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
239227391369.555.8627.9Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
239313691369.022.3522.4Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
239413691369.048.3748.4The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
239527371368.568.1234.1The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
239668411368.2166.5733.3Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
239713681368.020.8520.9Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
239813681368.036.2536.2Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
239968381367.6259.351.9Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
240041021367.3119.2739.8Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
240127341367.089.6244.8A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
240213671367.029.5529.6The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
240313671367.028.028.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
240427331366.588.2544.1Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
240513661366.031.3831.4Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
240627321366.087.0743.5Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
240727321366.065.3432.7Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
240813661366.031.9932.0Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
240940961365.391.330.4Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
241013651365.046.8746.9Multiple calcium channels and neuronal function. R J MillerScience19872432656No
241127301365.074.2937.1miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
241281861364.3205.134.2A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
241313641364.029.7529.8Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
241427281364.066.6633.3Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
241527281364.066.5533.3The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
241627271363.576.3838.2Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
241727271363.580.340.1The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
241813631363.024.2524.2Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
241913631363.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
242027231361.553.3626.7A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
242127231361.559.3429.7NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
242227221361.056.3928.2Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
242313611361.046.3846.4Interleukin-1. C A DinarelloRev Infect Dis19846369481No
242413611361.029.9429.9Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
242513611361.036.3836.4Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
242627211360.596.0748.0A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
242740811360.3116.638.9A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
242895211360.1387.255.3Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
242913601360.032.732.7Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
243013601360.037.9437.9Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
243113601360.040.5840.6Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
243227191359.579.7339.9A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
243313591359.052.5452.5What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
243427181359.076.2538.1The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
243513581358.043.0243.0Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
243613581358.043.5343.5History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
243713581358.024.5724.6c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
243827141357.061.530.8Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
243927141357.055.2427.6Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
244013561356.056.3956.4Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
244113551355.064.6264.6Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
244240631354.398.9633.0Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
244327081354.0131.8665.9Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
244413541354.042.4542.5Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
244513541354.036.0636.1Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
244667701354.0303.4560.7BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
244713541354.057.7457.71,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
244854131353.2134.9633.7Universal sample preparation method for proteome analysis. Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
244913531353.050.8150.8Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
245027041352.062.4831.2NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
245113521352.027.5927.6The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
245227031351.5108.7354.4A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
245313511351.029.029.0Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
245454041351.0127.2631.8The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
245513511351.029.5829.6Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
245640521350.7148.1349.4Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
245713501350.032.632.6Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
245826991349.589.7244.9Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
245913491349.041.1141.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
246013491349.028.6328.6HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
246113481348.042.0642.1Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
246213481348.026.9326.9Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
246326931346.591.1945.6Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
246413461346.034.7134.7The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
246513451345.050.4450.4Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
246613451345.026.0126.0Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
246713451345.035.5635.6Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
246813451345.033.6333.6A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
246913451345.029.4529.4Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
247013451345.041.6841.7Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
247153771344.2124.231.1Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
247213441344.020.3920.4A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
247326871343.593.8746.9Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
247413431343.028.428.4The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
247526851342.561.4430.7The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
247613421342.039.7339.7Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
247713421342.025.8625.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
247813421342.041.9642.0Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
247913421342.031.6231.6Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
248013421342.045.1745.2AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
248126831341.582.9541.5Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
248267051341.0182.136.4Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
248313411341.036.0136.0Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
248426821341.078.3139.2Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
248513411341.0111.29111.3Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
248626811340.590.045.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
248713401340.038.9939.0Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
248813401340.030.2330.2Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
248926791339.571.9336.0Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
249013391339.045.045.0Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
249126781339.064.332.1Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
249213381338.035.6135.6Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
249326761338.059.7529.9A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
249426751337.564.7532.4Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
249526741337.060.7330.4Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
249613371337.028.6428.6The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
249713371337.022.9923.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
249826731336.554.2427.1Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
249913361336.035.0235.0The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
250013361336.064.2564.2The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
250113361336.025.5925.6microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
250226711335.567.4833.7Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
250313351335.060.260.2Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
250413351335.041.9842.0The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
250540051335.0100.5333.5LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
250613351335.038.0138.0Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
250713351335.034.0434.0Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
250826701335.083.2941.6Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
250913341334.025.6625.7Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
251026681334.079.7639.9Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
251126661333.072.8536.4A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
251213331333.047.1247.1Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
251313331333.027.8327.8Human natural killer cells. Michael A CaligiuriBlood200818650461No
251413331333.055.755.7Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
251539971332.390.5730.2Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
251639961332.0102.7634.3Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
251713321332.033.2833.3Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
251813321332.027.2127.2Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
251913321332.032.9232.9N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
252053241331.0117.5429.4Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
252113301330.039.5439.5Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
252239901330.0107.2435.7Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
252313291329.045.3745.4Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
252413291329.033.8633.9Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
252513291329.023.4423.4SUMO: a history of modification. Ronald T HayMol Cell200515808504No
252653141328.5132.3833.1Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
252726571328.561.5730.8Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
252839851328.3138.6446.2Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graça Raposo, Clotilde ThéryAnnu Rev Cell Dev Biol201425288114No
252913281328.034.734.7The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
253013281328.063.2563.2Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
253113271327.055.455.4Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
253239791326.387.5829.2Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
253313251325.050.7750.8Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
253413251325.040.6540.6Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
253526491324.558.2929.1Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
253613241324.048.048.0The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
253726481324.055.727.9Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
253813241324.013.1413.1Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
253913241324.030.2230.2Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
254026471323.560.3630.2Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
254113231323.043.5143.5Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
254226441322.0101.3650.7Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
254313221322.029.8429.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
254439651321.755.9218.6Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
254513211321.042.5442.5An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
254652841321.0227.9257.0Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
254713211321.032.4832.5Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
254813201320.031.6631.7Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
254913201320.022.9823.0Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
255026401320.046.4723.2Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
255126391319.5100.6550.3Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
255239581319.397.4332.5The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
255326381319.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
255413191319.028.2928.3Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
255513181318.050.5150.5Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
255613181318.029.9329.9Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
255713181318.035.2235.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
255826351317.559.5629.8Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
255939521317.3141.0747.0A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
256039521317.383.9428.0A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
256126341317.0123.661.8Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
256226341317.049.0224.5New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
256313171317.038.8638.9Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
256439491316.391.4430.5Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
256513161316.045.2845.3Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
256613161316.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
256726311315.583.1341.6DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
256839451315.080.8727.0Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
256952571314.2123.7430.9Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
257013141314.022.9923.0Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
257139401313.393.2831.1Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
257278801313.3199.0133.2Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
257313131313.054.5154.5Error in medicine. L L LeapeJAMA19947503827Yes
257413131313.035.4535.5Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
257513131313.038.3438.3Endometriosis. Serdar E BulunN Engl J Med200919144942No
257613121312.037.3137.3The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
257713121312.016.6216.6Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
257826241312.067.8833.9Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
257913121312.033.1333.1Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
258039361312.0101.9234.0Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
258126231311.556.7528.4Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
258291791311.3229.5832.8Integrative genomics viewer. James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
258313111311.039.3939.4Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
258413111311.033.9233.9Supported membranes: scientific and practical applications. E SackmannScience19968539599No
258513111311.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
258613111311.028.6928.7Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
258726211310.555.827.9The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
258826211310.5105.9353.0Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
258965511310.2123.3524.7Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
259013101310.027.7227.7Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
259113101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
259226191309.548.6924.3Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
259326191309.5135.1567.6Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
259413091309.034.6434.6Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
259513091309.069.9870.0Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
259613091309.037.437.4Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
259713091309.027.8127.8Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
259813091309.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
259952351308.8104.526.1Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
260026171308.539.0519.5Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
260139251308.3132.3644.1Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
260226161308.059.5329.8Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
260313081308.033.4933.5Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
260426151307.540.3120.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
260526151307.557.4428.7Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
260626141307.069.8634.9Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
260713071307.040.7440.7Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
260813071307.055.0155.0The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
260926141307.0175.4687.7OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
261013061306.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
261113061306.033.9834.0The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
261213061306.0111.22111.2COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
261313051305.035.6335.6The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
261426101305.062.2731.1C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
261513041304.041.8441.8How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
261613041304.040.040.0Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
261713031303.024.4224.4Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
261813031303.032.1232.1Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
261939091303.0151.0650.4Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
262026041302.076.4738.2Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
262126041302.038.6119.3Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
262213021302.044.5844.6The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
262313021302.079.5179.5A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
262413021302.037.6637.7Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
262513011301.022.2222.2Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
262626021301.043.3521.7Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
262713011301.030.2130.2Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
262826021301.074.8837.4Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
262926021301.077.5238.8Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
263013001300.042.0942.1The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
263113001300.048.548.5Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
263238991299.787.7829.3Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
263364981299.6159.8632.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
263412991299.031.9531.9Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
263512991299.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
263677921298.7194.7732.5An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
263738951298.391.1230.4Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
263812981298.027.0627.1Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
263925951297.5161.1980.6Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
264012971297.031.0831.1Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
264112971297.029.6729.7The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
264225921296.00.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
264312961296.032.8532.9Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
264412961296.068.8468.8ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
264525901295.082.641.3Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
264612951295.028.4128.4Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
264725881294.061.6730.8Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
264812941294.023.4323.4CD95's deadly mission in the immune system. P H KrammerNature200011048730No
264912941294.027.2127.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
265012941294.038.838.8Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
265125871293.567.5633.8Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
265225861293.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
265312931293.035.4335.4Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
265412931293.044.4544.5PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
265538771292.3127.3742.5Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
265612921292.061.2261.2Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
265712921292.031.131.1Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
265825841292.064.232.1Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
265925841292.055.6527.8Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
266051681292.0113.7728.4A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
266112911291.042.5842.6Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
266212911291.042.2942.3Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
266312911291.029.4929.5Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
266412911291.029.2129.2Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
266512911291.030.2230.2Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
266612911291.071.6471.6DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
266751621290.5253.9563.5Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
266812901290.034.9234.9Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
266925801290.059.1229.6Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
267025791289.571.2535.6What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
267112891289.029.5529.6The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
267225781289.059.6729.8Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
267312891289.023.9323.9Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
267425761288.057.3728.7The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
267512881288.036.9937.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
267612881288.010.6810.7Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
267725751287.5130.7565.4A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
2678141601287.3381.6234.7The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
267912871287.039.7839.8Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
268012871287.026.9326.9Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
268112871287.036.7436.7Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
268225731286.588.1344.1Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
268351451286.2207.251.8QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
268412861286.031.7631.8The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
268512861286.056.3756.4Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
268612861286.034.1734.2The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
268725711285.582.2241.1Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
268825711285.555.0327.5The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
268938561285.397.8632.6Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
269012851285.038.8938.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
269112851285.036.8936.9A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
269212851285.046.9246.9Substance P. B PernowPharmacol Rev19836196797No
269312851285.045.3145.3Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
269412851285.022.4822.5The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
269512851285.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
269612841284.030.4430.4Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
269725681284.063.5431.8Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
269825681284.046.0323.0DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
269912841284.027.2927.3Sustainable hydrogen production. John A TurnerScience200415310892Yes
270025681284.069.434.7Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
270125671283.546.7623.4Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
270238481282.7108.8836.3The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
270325651282.560.9230.5Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
270451301282.5184.4246.1The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
270525651282.5105.0452.5The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
270612811281.011.3711.4Immunological function of the thymus. J F MillerLancet196114474038Yes
270712811281.034.5534.5How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
270825621281.094.5847.3Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
270912811281.084.8884.9SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
271025611280.565.6832.8Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
271125611280.523.4511.7Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
271225601280.089.444.7Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
271312801280.032.1532.1Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
271489581279.7252.336.0Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
271525591279.552.6726.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
271612781278.042.4542.5Bee and wasp venoms. E HabermannScience19724113805No
271712781278.060.7460.7New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
271812781278.043.143.1Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
271925561278.081.8940.9The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
272025551277.562.7831.4The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
272112771277.031.3931.4Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
272238301276.791.1330.4Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
272312761276.039.3639.4Somatostatin. S ReichlinN Engl J Med19836139753No
272412761276.035.1935.2Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
272512761276.036.1736.2Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
272625511275.551.8825.9Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
272712751275.021.7121.7Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
272812751275.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
272912751275.038.8438.8Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
273012751275.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
273125481274.049.0724.5Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
273225481274.061.5230.8Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
273338211273.7170.8957.0In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
273425471273.596.9648.5Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
273525461273.069.0934.5Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
273612731273.029.0129.0Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
273712731273.031.7631.8TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
273812731273.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
273925451272.567.1533.6Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
274025441272.078.8739.4Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
274112721272.040.5440.5Function and information content of DNA methylation. Dirk SchübelerNature201525592537No
274263601272.0248.9849.8The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
274325431271.5156.3878.2A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
274425421271.0226.17113.1Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
274512711271.033.4133.4Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
274625411270.576.0638.0An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
274712701270.025.625.6Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
274812701270.030.1830.2Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
274925391269.550.2625.1A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
275012691269.026.6326.6Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
275112691269.033.8533.9Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
275212691269.036.1436.1Plant productivity and environment. J S BoyerScience198217808529Yes
275325361268.057.1728.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
275438041268.0103.3734.5Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
275512681268.037.2237.2Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
275625341267.049.1724.6CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
275712671267.028.3428.3Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
275812671267.028.6328.6Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
275912661266.031.4931.5Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
276012661266.055.4955.5Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. Alice Y Y ChengCan J Diabetes201324070926No
276125311265.566.4733.2Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
276237941264.7141.5247.2Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
276325291264.563.8631.9An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
276437931264.3112.1437.4The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
276512641264.034.2234.2Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
276612631263.031.231.2Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
276712631263.033.4333.4The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
276837881262.790.1230.0Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
276925251262.567.3733.7Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
277050491262.2116.6429.2Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
277112621262.032.1432.1Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
277212621262.028.8128.8Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
277312621262.040.8440.8Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
277412621262.034.9735.0T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
277575711261.8217.5436.3Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
277637851261.773.0224.3Exosomes: composition, biogenesis and function. Clotilde Théry, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
277725231261.551.025.5ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
277812611261.030.4330.4Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
277912611261.026.0526.1Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
278025211260.544.2522.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
278112601260.033.8533.9Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
278212601260.036.1636.2Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
278312601260.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
278425191259.555.9528.0Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
278512591259.014.0314.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
278637771259.0118.0439.3MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
278712591259.027.2527.2S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
278825181259.021.0310.5Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
278912581258.025.7925.8SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
279012581258.025.7125.7Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
279112581258.039.639.6Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
279212581258.053.2553.2Inflammation, metaflammation and immunometabolic disorders. Gökhan S HotamisligilNature201728179656No
279350301257.5144.8236.2Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
279425151257.561.7730.9Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
279512571257.034.734.7Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
279612571257.029.529.5Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
279712571257.026.7126.7Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
279812571257.053.3953.4Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
279925131256.585.1342.6Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
2800138171256.1354.3932.2Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnieJ Gerontol A Biol Sci Med Sci200111253156Yes
280125121256.073.136.5Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
280212561256.042.8942.9Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
280325121256.047.0723.5The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
280425121256.063.0431.5Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
280512561256.042.0542.0Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
280662761255.2151.7630.4Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J BartonBioinformatics200919151095Yes
280712551255.046.8646.9Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
280812551255.063.2263.2Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
280912551255.034.8634.9The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
281012551255.026.7226.7Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
281112541254.024.4924.5Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
281225081254.061.5630.8Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
281312541254.026.7526.8Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
281450141253.5105.0326.3Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
281525071253.548.7524.4Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
281637601253.3111.3437.1Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
281712531253.032.7232.7Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
281812531253.030.4930.5Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
281912531253.032.232.2Drug delivery and targeting. R LangerNature19989579855No
282012531253.028.5928.6Optical microcavities. Kerry J VahalaNature200312917698Yes
282112531253.023.5223.5ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
282212521252.082.7982.8The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
282312521252.042.2142.2Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
282412521252.031.5431.5Apoptosis. J J CohenImmunol Today19938466628No
282525041252.048.5724.3Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
282625041252.063.6431.8Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
282712521252.035.3335.3Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
2828137711251.9328.2829.8New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
282937551251.7112.4837.5Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
283025031251.557.9129.0DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
283125031251.588.2944.1Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
283212511251.030.3330.3Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
283312511251.027.7127.7Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
283437521250.7103.9634.7Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
283525011250.568.534.2The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
283612501250.057.5957.6A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
283712501250.024.8524.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
283837501250.087.7729.3Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
283912501250.023.9223.9A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
284012501250.025.8925.9The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
284187491249.9259.1637.0Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
284224981249.064.8432.4Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
284324971248.566.7233.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
284412481248.020.620.6Antigen receptor tail clue. M RethNature19892927501Yes
284512481248.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
284624961248.062.6831.3Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
284724961248.097.8548.9Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
284849911247.8131.1432.8Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
284949911247.8182.0745.5Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior PachterNat Biotechnol201627043002Yes
285024951247.563.9232.0Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
285124951247.587.5643.8Nitric oxide synthases: regulation and function. Ulrich Förstermann, William C SessaEur Heart J201221890489No
285224941247.068.734.4Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
285312471247.038.2738.3Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
285424941247.053.4326.7Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
285512471247.032.0632.1Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
285612471247.033.7133.7Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
285712471247.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
285812461246.049.9850.0The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
285924911245.590.4345.2The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
286012451245.022.7822.8Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
286112451245.035.4235.4Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
286212451245.046.5346.5Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
286349801245.0187.3546.8Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
286424891244.547.9224.0Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
286524891244.549.3724.7Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
286612441244.044.3944.4The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
286712441244.027.5327.5Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
286824881244.055.8327.9Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
286912441244.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
287012441244.032.4732.5Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
287112441244.032.5432.5Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
287224871243.563.2931.6Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
287312431243.051.8851.9A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
287412431243.028.7928.8A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
287512431243.030.0930.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
287612421242.042.2142.2How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
287712421242.035.8535.9Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
287812421242.099.3299.3The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020. The Novel Coronavirus Pneumonia Emergency Response Epidemiology TeamChina CDC Wkly202034594836Yes
287924831241.5102.9451.5Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
288049641241.0280.2470.1Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
288112411241.033.3633.4Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
288212401240.024.6224.6STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
288312401240.045.2845.3Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
288412401240.041.1841.2Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
288561981239.6231.0646.2DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
288637181239.3183.2361.1Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
288712391239.024.3224.3Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
288812391239.032.9232.9Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
288912391239.038.2938.3Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
289024761238.076.5138.3Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
289112381238.048.348.3Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
289212381238.032.3932.4The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
289312381238.029.729.7Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
289424761238.066.033.0Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
289512381238.029.0229.0Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
289624731236.561.2730.6Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
289724731236.564.9332.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
289824731236.543.621.8Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
289912361236.029.9429.9Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
290012361236.037.5837.6Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
290112361236.026.4226.4Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
290212361236.020.3120.3The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
290312361236.039.0839.1The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
290412361236.045.0245.0Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
290598861235.8253.131.6A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
290624711235.557.1728.6Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
290724701235.048.3324.2Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
290812341234.064.1564.2Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
290937021234.0115.4638.5Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
291012341234.057.7657.8When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
291137011233.7116.2638.8Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
291212331233.032.432.4Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
291312321232.038.6938.7Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
291412321232.027.7627.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
291512321232.055.755.7Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
291612311231.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
291724611230.568.4134.2Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
291824611230.5229.53114.8The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
291961521230.4192.4738.5Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
292012301230.030.1730.2Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
292112301230.030.9631.0Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
292212301230.045.2745.3The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
2923196761229.8558.7834.9New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
292461491229.8331.0166.2ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
292512291229.021.3421.3Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
292612291229.044.1344.1Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
292712291229.049.3449.3Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
292812291229.022.6922.7Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
292912291229.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
293012291229.037.1837.2Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
293124571228.539.5319.8A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
293224571228.572.8536.4Inflammatory mechanisms in obesity. Margaret F Gregor, Gökhan S HotamisligilAnnu Rev Immunol201121219177No
293373701228.3244.7540.8The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeJ Clin Epidemiol200818313558Yes
293424561228.074.9437.5bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
293524551227.565.8132.9Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
293612271227.045.0345.0The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
293712271227.026.3926.4Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
293849051226.2156.9539.2Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
293912261226.031.931.9Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
294012261226.043.3743.4Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
294112261226.027.2827.3Brain tumors. L M DeAngelisN Engl J Med200111150363No
294212261226.037.8237.8Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
294312261226.030.930.9Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
294424511225.554.7127.4Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
294512251225.055.5655.6Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
294612251225.024.5124.5Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
294712251225.054.5254.5The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
294812241224.033.8333.8Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
294912241224.025.1225.1Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
295024461223.048.5724.3Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
295112231223.034.9134.9High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
295212221222.022.2322.2Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
295312221222.020.1920.2Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
295412221222.031.1731.2The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
295512211221.025.3325.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
295612211221.022.0822.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
295712211221.017.4417.4Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
295812211221.033.8333.8Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
295973221220.3204.4634.1Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
296012201220.028.6828.7Growth factors and cancer. S A AaronsonScience19911659742No
296112201220.025.725.7Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
296212201220.030.8330.8Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
296312201220.033.4933.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
296485401220.0294.7942.1Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
296512201220.074.674.6Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
296624391219.558.3329.2Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
296712191219.026.626.6Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
296824361218.074.9137.5A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
296912181218.030.4630.5Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
297012181218.025.9125.9Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
297112181218.032.732.7The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
297212181218.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
297324361218.057.5728.8Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
297412171217.016.5816.6The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
297512171217.025.2425.2Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
297624341217.094.1947.1Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
297724331216.50.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
297812161216.045.4445.4A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
297912161216.059.0259.0ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
298012161216.031.8331.8Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
298124321216.064.1632.1A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
298212161216.034.4134.4Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
298348641216.0134.5733.6AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
298424321216.062.8431.4The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
298536471215.761.4120.5A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
298624311215.547.8923.9Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
298712151215.044.5544.5Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
298812151215.025.0625.1Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
298912151215.023.423.4Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
299024281214.078.5139.3Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
299124281214.062.1631.1Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
299248551213.8112.7628.2Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
299312131213.042.342.3Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
299412131213.037.8337.8Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
299512131213.034.9234.9The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
299612131213.051.1551.1The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
299712121212.020.8320.8Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
299824241212.032.1716.1The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
299912121212.046.8446.8A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
300060571211.4246.0649.2Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
300112111211.029.3529.4Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
300224221211.036.4318.2High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
300312111211.025.0525.1Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
300424211210.552.6726.3Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
300572621210.3135.0122.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
300612101210.023.123.1IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
300712101210.024.124.1Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
300824181209.097.1548.6The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
300912091209.061.9562.0Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
301012091209.024.2624.3Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
301136261208.775.9625.3Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
301260401208.0294.9359.0Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
301312071207.038.4638.5Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
301412071207.026.2326.2An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
301512071207.026.7426.7Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
301624141207.068.7634.4Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
301724141207.066.6733.3New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
301812071207.058.5758.6The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
301936201206.7102.1634.1Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
302024131206.559.8329.9Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
302148251206.2150.4637.6Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
302212061206.031.231.2Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
3023108541206.0277.5330.8MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
302436161205.3111.5237.2Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
302548211205.2131.4132.9Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
302612051205.052.7352.7Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
302712051205.048.4748.5Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
302812051205.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
302912051205.029.7929.8Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
303012051205.044.7744.8The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
303112041204.028.2328.2Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
303224081204.059.0929.5Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
303336111203.772.1924.1Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
303424071203.571.2335.6Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
303524071203.546.1923.1Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
303612031203.040.940.9The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
303724061203.064.432.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
303812031203.034.3834.4MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
303936071202.3267.6589.2Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
304048091202.2127.3631.8Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
304124041202.049.9725.0Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
304212021202.041.3841.4Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
304312021202.025.6325.6The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
304412021202.032.9432.9The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
304512021202.058.4958.5The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
304612011201.033.0233.0Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
304712011201.019.8119.8Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
304812011201.033.3833.4Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
304912011201.023.4523.4A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
305012011201.023.7723.8Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
305112011201.033.8133.8Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
305224011200.563.0231.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
305348021200.5132.1733.0Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
305412001200.037.1637.2Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
305512001200.027.0327.0Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
305635991199.786.7528.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
305723981199.053.2326.6Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
305811991199.028.6128.6Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
305923971198.549.0724.5NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
306011981198.034.9935.0A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
306111981198.032.9533.0Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
306211981198.030.2930.3Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
306311981198.032.0732.1Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
306447921198.0135.0233.8Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
306535921197.373.224.4Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
306611971197.034.9635.0Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
306711971197.041.041.0Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
306811971197.029.829.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
306911971197.028.0928.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
307011971197.029.0229.0The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
307111971197.035.1335.1The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
307211971197.020.8120.8Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
307311971197.030.3730.4Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
307411971197.025.8825.9Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
307523931196.561.3630.7Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
3076119651196.5431.8343.2The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
307711961196.038.1638.2The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
307811961196.034.0634.1What is synergy? M C BerenbaumPharmacol Rev19892692037No
307911961196.034.934.9Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
308023921196.061.8930.9Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
308123901195.049.5524.8Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
308223891194.585.0742.5Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
308311941194.028.4728.5Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
308411941194.030.2330.2Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
308511941194.028.4828.5Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
308659691193.8200.3740.1Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
308735801193.3217.0372.3Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
308823861193.065.7832.9Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
308911931193.048.9749.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
309011931193.036.1336.1The mysteries of lipoprotein(a). G UtermannScience19892530631No
309135791193.089.3329.8Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
309223861193.071.3235.7Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
309323841192.096.2148.1Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
309411921192.040.1540.1Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
309523821191.0213.69106.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
309611911191.036.8136.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
309711911191.025.625.6The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
309811911191.046.6746.7The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
309923811190.569.3834.7Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
310059521190.4141.3528.3Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
310135711190.3165.5855.2Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
310247611190.2137.7934.4Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
310311901190.038.9238.9Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
310411901190.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
310535701190.090.7530.2Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
310623801190.084.6542.3Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
310711891189.021.421.4Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
310811891189.028.328.3A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
310911891189.022.4422.4The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
311011891189.025.9926.0How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
311123781189.096.5648.3Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
311211891189.066.1466.1Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
311335661188.783.4627.8Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
3114106961188.4273.5330.4Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
3115106951188.3353.9439.3A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
311611881188.021.8421.8Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
311723761188.048.624.3The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
311835621187.385.6928.6Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Rönnbäck, Elisabeth HanssonNat Rev Neurosci200616371949No
311923741187.0113.256.6Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
312035611187.0110.236.7The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
312111871187.019.1819.2Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
312211871187.039.0139.0Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
312311871187.023.4823.5Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
312411871187.039.4839.5Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
312523731186.566.6233.3Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
312611861186.042.6842.7The case for motivated reasoning. Z KundaPsychol Bull19902270237No
312711861186.052.4952.5Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
312811861186.073.9373.9Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
312911861186.045.545.5Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
313023721186.052.4326.2Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
313123711185.595.4647.7Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
313223701185.088.1744.1Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
313311851185.026.7626.8The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
313423701185.074.0937.0Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
313535551185.072.1324.0Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
313611851185.030.6630.7The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
313711851185.058.0558.0Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
313823691184.5102.6351.3Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
3139165791184.2353.9925.3Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
314011841184.065.6365.6Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
314111841184.036.2836.3The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
314223681184.043.6521.8Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
314311841184.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
314423671183.547.8823.9Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
314535501183.3150.3150.1Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
314670991183.2266.0244.3Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
314723661183.076.5738.3Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
314811831183.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
314911831183.044.144.1Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
315011821182.038.0738.1Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
315111821182.024.424.4Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
315223631181.552.8926.4Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
315323631181.576.538.2Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
315423631181.594.4247.2Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
315511811181.026.8326.8Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
315611811181.032.4932.5The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
315711811181.035.7935.8Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
315882651180.7162.7823.3Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
315935421180.7116.2238.7Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
316059031180.6192.2738.5Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
316111801180.041.0641.1An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
316211801180.031.6531.6Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
316311801180.035.9235.9A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
316423601180.054.627.3Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
316511801180.045.2445.2Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
316647181179.5106.426.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
316723591179.577.3638.7Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
3168117931179.3296.3529.6Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
3169117921179.2458.5745.9MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
317023581179.076.0438.0Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
317111791179.027.5227.5Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
317211791179.022.9222.9Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
317323571178.548.5524.3Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
317435351178.3120.7140.2The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
317511781178.024.6424.6The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
317611781178.042.142.1Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
317723551177.563.331.6A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
317823541177.068.0834.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
317911771177.013.6713.7Central dogma of molecular biology. F CrickNature19704913914No
318023541177.042.121.1Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
318111771177.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
318258841176.8166.533.3Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
318323531176.572.9336.5The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
318423521176.080.6640.3The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
318511761176.038.9238.9Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
318611761176.028.1128.1Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
318723511175.550.5125.3Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
318847011175.290.122.5Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
318923501175.0112.1856.1Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
319011751175.0107.73107.7The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
319111751175.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
319211751175.026.7626.8Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
319335241174.790.1230.0Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
319423491174.560.9930.5Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
319523491174.571.4135.7Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
319611741174.033.4933.5On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
319723471173.591.845.9A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
319823461173.046.1223.1Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
319923461173.053.9127.0Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
320035181172.7104.3334.8SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
320111721172.030.8130.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
320211721172.035.8435.8Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
320311721172.047.6547.6The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
320411721172.049.3849.4The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615No
320511721172.049.7749.8How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
320635131171.070.6923.6Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
320711711171.024.0624.1Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
320811711171.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F RosenblattPsychol Rev195813602029Yes
320935111170.392.2730.8Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
321023401170.036.7618.4Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
321111701170.033.033.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
321211701170.030.6530.6A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
321358491169.8109.2721.9The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
321423391169.553.9727.0Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
321523381169.074.1137.1Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
321611691169.034.1534.1Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
321711691169.030.6630.7Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
321811691169.021.9622.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
321923381169.048.7224.4Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
322011691169.027.9728.0Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
322170111168.5239.6239.9The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
322235051168.3144.1848.1Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
322311681168.045.2545.2Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
322411681168.039.3739.4beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
322511681168.025.1125.1Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
322635041168.091.7830.6Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
322711671167.027.5527.6The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
322846681167.0108.6727.2Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
322911671167.017.2517.2The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
323035001166.777.0925.7Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
323123331166.569.5634.8Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
323223331166.549.3624.7Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
323323331166.568.5534.3Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
323434991166.3180.0260.0Hepatocellular carcinoma. Alejandro Forner, María Reig, Jordi BruixLancet201829307467No
323511661166.035.735.7MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
323611661166.048.7248.7A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
323711661166.034.6834.7Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
323811661166.024.624.6Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
323911661166.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
324011661166.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
324111661166.058.5958.6Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
324234971165.7140.3346.8Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
324311651165.026.1526.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
324411651165.026.826.8Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
324511651165.023.5723.6Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
324611641164.044.2644.3Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
324711641164.021.3921.4Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
324811641164.078.6878.7Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
324911631163.034.8534.9Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
325011631163.030.7630.8Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
325134891163.079.7626.6Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
325211631163.051.1951.2Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
325311631163.031.6731.7Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
325423261163.069.6434.8Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
325523251162.5243.43121.7Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
325611621162.011.2911.3Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
325711621162.019.9820.0Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
325823241162.049.6224.8Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
325934861162.0106.7235.6Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
326023231161.550.1625.1Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
326123231161.554.6227.3Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
326234841161.388.4329.5The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
326311611161.056.6156.6The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
326411611161.036.4636.5Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
326511611161.074.0574.0Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
326669651160.8155.5725.9Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
326734821160.795.6231.9Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
326823211160.548.0824.0Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
326923211160.554.4727.2ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
327069611160.2201.0533.5The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
327123191159.566.8133.4Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
327223191159.568.0734.0The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
327311591159.044.044.0Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjöströmJ Intern Med201323163728No
327411581158.025.9325.9Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
327511581158.021.9321.9Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
327611581158.022.2522.2Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
327711581158.032.7932.8Rethinking schizophrenia. Thomas R InselNature201021068826No
327823151157.561.630.8BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
327911571157.021.5321.5Biogenic amines and the states of sleep. M JouvetScience19694303225No
328011571157.011.9712.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
328111571157.029.529.5The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
328223141157.050.9125.5Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
328311571157.027.9728.0Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
328423141157.099.8149.9The lifelong effects of early childhood adversity and toxic stress. Jack P Shonkoff, Andrew S GarnerPediatrics201222201156Yes
328523131156.543.7121.9Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
328623121156.054.8827.4Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
328711561156.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
328834671155.785.5328.5High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
328923111155.549.7424.9Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
329011551155.021.1821.2RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
329123101155.070.3235.2Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
329223091154.564.8732.4Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
329311541154.055.8655.9Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
329411541154.035.8535.9Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
329523081154.043.8221.9NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
329623071153.547.423.7Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
329711531153.029.0729.1Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
329811531153.015.5915.6The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
329911531153.042.9743.0Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
330023061153.050.5825.3Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
330123061153.054.9827.5ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoît D'Autréaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
330211521152.026.7426.7Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
330311521152.046.1446.1The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
330411521152.024.1124.1Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
330523041152.050.8925.4Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
330623031151.571.1335.6Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
330723031151.546.523.2A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
330823031151.578.9439.5A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
330923031151.551.7525.9Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
331023031151.551.7425.9The Polycomb complex PRC2 and its mark in life. Raphaël Margueron, Danny ReinbergNature201121248841No
331111511151.060.1760.2A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
331223021151.066.8233.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
331311511151.025.4225.4Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
331411501150.022.0222.0Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
331511501150.035.8535.9Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
331611501150.027.8727.9Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
331711501150.031.4331.4Leishmaniasis. B L HerwaldtLancet199910513726No
331823001150.058.9729.5Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
331923001150.033.916.9A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H Vandendool, P D KratzJ Chromatogr196314062605Yes
332023001150.051.0925.5microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
332123001150.097.4148.7Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958No
332222991149.562.3831.2Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
332311491149.024.1124.1Stem cells in the central nervous system. R McKayScience19979082987No
332411491149.025.0225.0G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
332511491149.022.3422.3Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
332611491149.00.00.0Comparing individual means in the analysis of variance. J W TukeyBiometrics194918151955Yes
332711491149.030.7730.8AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
332811491149.027.9728.0Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
332911481148.034.2734.3Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
333022961148.051.2125.6Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
333111481148.022.0422.0Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
333222961148.076.9838.5Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
333311481148.026.5726.6Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
333434431147.798.4432.8A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
333511471147.031.1331.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
333611471147.020.3620.4Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
333711471147.025.0525.1r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
333811471147.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
333922931146.551.1725.6Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
334011461146.031.531.5Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
334111461146.023.3923.4Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
334211451145.031.9732.0DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
334322891144.567.0433.5Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
334422891144.5105.2152.6Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
334511441144.045.6545.6Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
334611441144.026.7226.7Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
334722881144.066.9533.5Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
334811441144.028.0928.1Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
334911441144.046.7446.7How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
335045751143.8110.7227.7Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
335111431143.042.1842.2Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
335222861143.085.3442.7Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
335311431143.021.5921.6The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
335411431143.025.6525.6Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
335522861143.063.8731.9Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
335634261142.0108.3236.1Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
335711421142.032.0132.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
335811421142.033.3733.4Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
335911421142.036.4736.5Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
336022831141.544.7622.4Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
336111411141.020.7620.8Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
336222821141.060.5930.3Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
336322821141.061.3530.7Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
336422821141.042.6421.3The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
336522821141.072.636.3Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
336668441140.7156.3326.1Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
336722811140.561.4730.7Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
336834211140.391.830.6Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
336911401140.023.9924.0Evolution of ageing. T B KirkwoodNature1977593350Yes
337011401140.031.8331.8Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
337122791139.546.923.4Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
337211391139.022.7522.8Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
337322781139.065.5232.8Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
337422781139.071.9236.0Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
337511381138.028.6828.7Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
337611381138.033.8833.9Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
337711381138.038.5338.5Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
337811381138.024.0124.0Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
337911381138.021.821.8VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
338011381138.033.6133.6Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
338111381138.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
338211371137.040.3640.4Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
338311371137.013.1113.1A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
338411371137.030.6230.6A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
338511371137.030.8230.8Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
338622731136.544.222.1Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
338722731136.5156.1878.1An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
338811361136.053.0953.1Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
338911361136.030.3230.3Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
339011361136.028.0328.0Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
339122721136.051.3225.7Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
339211361136.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
339334061135.382.1427.4Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
339411351135.030.7930.8Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
339511351135.036.3236.3Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
339611351135.021.3321.3The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
339711351135.035.3535.4Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
339811351135.025.6725.7Viruses in the sea. Curtis A SuttleNature200516163346No
339911351135.047.547.5CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions. Gunther EysenbachJ Med Internet Res201122209829No
340034041134.793.6631.2Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
340122691134.558.5329.3Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
340222691134.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
340334031134.372.6324.2A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
340411341134.028.1728.2Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
340511341134.025.5825.6The columnar organization of the neocortex. V B MountcastleBrain19979153131No
340611331133.026.0526.1Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
340711331133.023.223.2Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
340833991133.0121.1640.4Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
340911331133.020.9420.9Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
341011331133.020.2620.3The development of neural stem cells. S TempleNature200111689956No
341111331133.020.1720.2NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
341245311132.8111.1927.8Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
341322651132.589.744.9Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
341411321132.021.7521.8Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
341511321132.032.2132.2Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
341611321132.032.4732.5The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
341711321132.0133.34133.3COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates. Malik SallamVaccines (Basel)202133669441No
341833941131.367.2422.4SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
341911311131.017.5217.5Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
342022611130.571.6135.8Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
342133911130.390.5730.2A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
342222601130.075.7137.9Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
342311301130.030.8930.9Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
342411301130.032.8432.8Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
342511301130.026.0826.1Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
342622601130.050.2725.1Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
342722601130.051.0225.5Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
342822591129.549.1424.6Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
342945181129.5247.4861.9The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
343079041129.1246.3335.2Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
343111291129.024.0324.0VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
343211291129.028.7428.7Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
343311281128.023.7323.7Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
343411281128.028.4528.4Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
343511281128.042.7642.8On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
343611281128.024.9825.0Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
343711281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
343811281128.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
343911281128.017.017.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
344022561128.075.3637.7The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
344111281128.075.7675.8Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
344211271127.022.1422.1Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
344311271127.023.9123.9Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
344422541127.055.0527.5The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
344522541127.059.3429.7Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
344611271127.020.5220.5DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
344722531126.531.7415.9Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
344822521126.059.3229.7Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
344911261126.029.5429.5Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
345011261126.022.3422.3Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
345122521126.043.421.7STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
345211261126.040.2940.3Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
345333771125.790.6930.2Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
345422511125.559.9630.0A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
345511251125.067.6567.7Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
345611251125.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
345711251125.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
345844991124.8211.7852.9Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GökerBMC Bioinformatics201323432962Yes
345922491124.583.9142.0Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
346011241124.023.7423.7Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
346122481124.082.6141.3The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
346222481124.051.7825.9The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
346311241124.037.8737.9Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
346433711123.796.1432.0Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681No
346522471123.592.2246.1Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
346611231123.050.0250.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
346711231123.051.6551.6Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
346811231123.037.2337.2Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
346911231123.032.8932.9Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
347011231123.023.4823.5ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
347144911122.8103.5825.9SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
347222451122.559.0829.5Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
347322451122.554.5827.3Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
3474112221122.2254.4925.4Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus SchultenJ Comput Chem200516222654Yes
347544881122.0108.0327.0C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
347611221122.056.9757.0Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
347722431121.584.3742.2The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
347822431121.545.9723.0Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
347922431121.547.8423.9Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
348022431121.563.8231.9Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
348144861121.51997.25499.3Cancer statistics, 2023. Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle, Ahmedin JemalCA Cancer J Clin202336633525Yes
348256071121.4110.8822.2Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
348311211121.030.0230.0The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
348433631121.0104.134.7PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
348511201120.034.534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
348611201120.031.6331.6Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
348744801120.0145.4136.4The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
348811201120.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
348911201120.030.5830.6Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532No
349033601120.089.6529.9Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
349122381119.059.0629.5Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
349211191119.025.8325.8Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
349322381119.077.2338.6A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschöpeJ Am Coll Cardiol201323684677No
349422371118.577.6238.8A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
349522371118.548.9124.5Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
349611181118.037.2337.2Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
349711181118.020.7720.8The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
349811181118.037.6137.6A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
349911181118.024.5824.6Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
350011181118.032.0232.0A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
350122351117.545.1322.6RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
350222351117.565.232.6Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
350333521117.392.830.9Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
350422341117.062.1831.1Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
350522331116.545.0522.5A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
350622331116.538.5819.3A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
350766991116.5145.0824.2Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
350811161116.039.5539.5Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
350911161116.028.628.6Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
351011161116.034.7234.7Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
351111161116.031.0831.1On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
351211161116.026.1726.2Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
351311161116.025.8825.9Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
351411151115.032.6532.6Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
351511151115.033.2733.3Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
351611151115.033.0833.1Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
351711151115.026.6426.6Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
351811141114.027.8527.9Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
351911141114.033.9534.0Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
352022281114.084.0142.0Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
352111131113.056.4456.4Osseointegration and its experimental background. P I BrånemarkJ Prosthet Dent19836352924No
352211131113.040.1540.1Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
352311131113.027.5427.5Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
352411131113.027.6627.7Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
352511131113.058.958.9The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
352622261113.0135.8667.9Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
352744511112.8116.8629.2Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
352822251112.569.7634.9Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
352922251112.579.6139.8Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
353033371112.376.9425.6Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
353122241112.071.7535.9Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
353222241112.075.9738.0Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
353322241112.049.5224.8Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
353411121112.024.7524.8Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
353511121112.024.1924.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
353611121112.099.6199.6The STROBE guidelines. Sarah CuschieriSaudi J Anaesth201930930717No
353722231111.565.2532.6Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
353811111111.052.1152.1Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
353922221111.035.1217.6Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
354011111111.026.4626.5Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
354111111111.023.6323.6Complement. Second of two parts. M J WalportN Engl J Med200111297706No
354211111111.021.1121.1Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
354311111111.022.922.9Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
354422221111.066.8833.4Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
354522211110.552.0126.0Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
354611101110.024.8724.9The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
354711101110.030.7730.8The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
354822201110.066.7333.4Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
354911101110.039.9940.0The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
355022201110.080.7540.4Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
355166581109.7174.5729.1Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
355211091109.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
355311091109.024.324.3Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
355422171108.552.4526.2Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
355511081108.021.8221.8Cytokine receptor signalling. J N IhleNature19957566171No
355611081108.036.5636.6Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
355711081108.025.4825.5Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
355811081108.028.9829.0Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
355922151107.588.3444.2Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde ThéryCell201626967288No
356022141107.053.6926.8Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
356111071107.021.3221.3Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
356222131106.549.824.9A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN Engl J Med200111759645Yes
356311061106.019.7919.8Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
356411061106.023.523.5Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
356533161105.3112.6337.5Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
356633161105.377.4225.8Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
356711051105.022.222.2Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
356811051105.043.3143.3A simple method for determination of serum catalase activity and revision of reference range. L GóthClin Chim Acta19912029780Yes
356911051105.038.7738.8Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
357011051105.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
357111051105.026.3326.3Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
3572121501104.5343.3331.2International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
357322091104.558.0129.0Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
357411041104.026.4326.4Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
357511041104.029.7229.7What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
357611041104.029.1129.1Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
357744151103.847.6311.9The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
357844151103.8147.7436.9Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
357911031103.023.2423.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
358022061103.054.0427.0Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
358111031103.026.326.3ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
358222051102.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
358344101102.5126.1731.5GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
358411021102.023.2623.3Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
358511021102.028.1428.1Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
358611021102.022.9623.0Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
358711021102.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
358811021102.045.9445.9A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
358922031101.551.5725.8T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
359011011101.032.3732.4Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
359111011101.032.9432.9Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
359222021101.048.2524.1Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
359311011101.029.0229.0An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
359433031101.098.3132.8HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
359511001100.033.4633.5Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
359611001100.028.1928.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
359711001100.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
359844001100.0218.6554.7NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
359910991099.042.4442.4The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
360010991099.027.3427.3The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
360110991099.025.1125.1The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
360221981099.047.0423.5Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
360332961098.799.5133.2Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
360421971098.548.9624.5Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
360521971098.582.9441.5The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
360610981098.056.656.6The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
360710981098.027.527.5A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
360810981098.025.4525.4BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
360910981098.020.2520.2Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
361010981098.038.2238.2Epidemiology of heart failure. Véronique L RogerCirc Res201323989710No
361121951097.545.6222.8p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
361221951097.543.9722.0Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
361321951097.5118.6859.3Sexually transmitted diseases treatment guidelines, 2015. Kimberly A Workowski, Gail A BolanMMWR Recomm Rep201526042815No
361421951097.5245.72122.9Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
361532921097.3156.1752.1Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
361610971097.027.7927.8Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
361710971097.019.0719.1Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
361810971097.024.3824.4The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
361910971097.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
362021931096.526.4313.2Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
362110961096.024.7524.8Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
362210961096.019.8319.8Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
362310961096.032.332.3Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
362410961096.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
362510961096.028.6728.7Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
362621911095.563.5431.8A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marçais, Carl KingsfordBioinformatics201121217122Yes
362754771095.4260.4252.1CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
362832861095.385.8628.6Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
362910951095.058.658.6The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
363010951095.020.7620.8Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
363121901095.082.3241.2Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
363221901095.065.8832.9Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
363321901095.063.3731.7The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
363410951095.029.929.9Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
363510951095.030.7530.8Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
363621891094.565.9133.02,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
363721891094.545.8422.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
363821881094.077.5238.8Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
363910941094.022.1922.2Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
364010941094.027.9127.9Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
364121871093.582.3441.2Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
364221871093.550.1125.1Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
364310931093.053.9554.0The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
364410931093.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
364510931093.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
364621851092.50.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
3647109241092.4360.6936.1The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
364832771092.3117.1839.1Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
364954611092.2115.0623.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
365010921092.022.422.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
365110921092.033.8733.9The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
365210921092.026.1426.1What is a support vector machine? William S NobleNat Biotechnol200617160063No
365365511091.8168.1128.0The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
365421831091.576.2338.1Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
365521821091.061.1730.6ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
365610901090.025.325.3Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
365710901090.023.9423.9Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
365810901090.025.1825.2P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
365921801090.040.220.1AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
366010901090.027.3127.3Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
366110901090.029.8229.8Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
366210901090.031.4231.4Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
366310891089.030.3130.3Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
366410891089.074.574.5Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
366510891089.028.5228.5Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
366632671089.068.7122.95-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
366754431088.6164.1632.8Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N CohnN Engl J Med19912057034Yes
366821771088.5112.3156.2The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
366921771088.554.9627.5Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
367021771088.553.1226.6Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
367121771088.589.0444.5Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
367232651088.3229.7176.6MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
367321761088.068.3134.2Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
367410881088.026.6326.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
367510881088.021.5221.5Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
367621761088.061.6430.8Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
367710881088.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
367810881088.033.4933.5Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BünzliChem Rev201020151630No
367910881088.052.2852.3Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
368065251087.5159.1526.5Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN Engl J Med200010639539Yes
368110871087.064.8464.8The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
368232611087.0128.8743.0Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
368310871087.024.1524.1The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
368421741087.097.6748.8Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
368510871087.027.5927.6Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
368621741087.060.8930.4Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
368710871087.033.0633.1On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
368810871087.039.9740.0Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamás RőszerMediators Inflamm201526089604No
368910861086.037.3837.4Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
369010861086.039.0439.0Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
369110861086.020.6120.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
369210861086.019.7519.8Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
369310861086.040.8940.9Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
369410861086.023.8523.9New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
369510861086.028.7528.8Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
369621721086.00.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
369710861086.025.3825.4Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WürthnerChem Commun (Camb)200415263926Yes
369810851085.022.5422.5T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
369910851085.015.8315.8The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
370010851085.022.5222.5Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
370110851085.033.8833.9The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
370221691084.550.9525.5Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
370354211084.2147.0529.4Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
370410841084.018.7518.8Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
370510841084.044.8644.9Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
370610841084.036.3436.3Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
370710841084.020.7620.8mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
370810841084.024.1924.2Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
370910841084.028.828.8Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
371010841084.024.8624.9Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
371132501083.387.5229.2Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
371210831083.025.4525.4Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
371310831083.021.4121.4Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
371443301082.5157.8639.5Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
371521651082.547.2623.6Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
371621641082.065.5632.8A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
371710821082.029.1829.2Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
371810821082.031.8231.8Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
371910811081.027.1727.2Avidin. N M GreenAdv Protein Chem1975237414Yes
372010811081.030.030.0A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
372110811081.019.0819.1Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
372232431081.063.2921.1Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
372310811081.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
372410811081.023.2923.3Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
372521611080.587.3143.7Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
372621611080.5104.5552.3Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
372710801080.041.3641.4A new international staging system for lung cancer. C F MountainChest19863514171No
372810801080.036.0436.0Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
372910801080.023.2123.2PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
373010801080.020.220.2Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
373110801080.013.6413.6Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
373221591079.563.5631.8Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
373321591079.589.7144.9AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
373410791079.027.0627.1Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
373521581079.045.0922.5Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr Opin Cell Biol19979069255No
373610791079.039.0739.1Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
373710791079.014.2714.3The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CroneActa Physiol Scand196314078649Yes
373810791079.028.5828.6Optogenetics. Karl DeisserothNat Methods201121191368Yes
373910781078.018.3518.4Evolution and tinkering. F JacobScience1977860134Yes
374010781078.054.1754.2The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
374121561078.043.3721.7A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
374264681078.0139.2123.2Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
374310781078.018.3118.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
374410781078.029.0529.1A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
374521561078.072.7536.4Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
374610781078.045.7545.8Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
374710781078.069.6869.7A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
374821551077.554.5227.3Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
374910771077.027.2127.2Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
375010771077.027.5127.5Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. J P TamProc Natl Acad Sci U S A19883399498Yes
375121541077.044.022.0The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
375210771077.026.5826.6The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
375310771077.029.1629.2Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
375410771077.028.1428.1Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
375510771077.032.832.8Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
375621531076.587.6543.8Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol Behav197614677603Yes
375710761076.032.7632.8Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
375810761076.029.029.0Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
375910761076.030.6330.6Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
376064541075.7178.8429.8Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
376164521075.3173.8229.0Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
376221501075.091.6345.8Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
376310751075.030.6130.6Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
376453751075.0196.6739.3A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
376521501075.070.1835.1Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
376610751075.031.4331.4ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
376721491074.584.0142.0Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
376810741074.037.3937.4Coronary physiology. E O FeiglPhysiol Rev19836296890No
376921481074.056.6628.3The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
377010741074.033.3833.4Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
377110741074.018.7918.8Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
377210741074.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
377310741074.030.2330.2The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
377410741074.027.427.4Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
377521471073.543.4221.7In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KärreImmunol Today19902201309No
377610731073.041.8541.9Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. W W StewartCell1978688392Yes
377710731073.046.0246.0Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
377810731073.043.1443.1Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
377910731073.051.9451.9Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
378042911072.8102.0625.5The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
378121451072.569.3834.7Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
378221441072.053.5226.8The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
378310721072.041.9842.0Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
378410721072.030.9530.9Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
378521441072.089.3344.7The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
378621431071.599.5949.8Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
378721421071.037.5918.8Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
378810711071.023.3323.3ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
378910711071.027.2627.3Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
379032131071.079.0226.3METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Gonçalo R AbecasisBioinformatics201020616382Yes
379132111070.3117.439.1Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
379221401070.063.1131.6Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
379310701070.026.2426.2Biological effects of resveratrol. L FrémontLife Sci200010680575No
379410701070.028.5628.6Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
379510701070.025.5925.6Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
379610701070.025.9525.9Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
379710701070.024.1824.2The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
379810701070.029.4529.4Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
379942791069.8110.5327.6A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
380010691069.043.743.7Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
380110691069.028.0828.1Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
380210691069.026.3926.4Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
380310691069.041.9141.9Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
380442741068.5109.7427.4Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
380521371068.554.7927.4Modified reagents for determination of urea and ammonia. A L Chaney, E P MarbachClin Chem196213878063Yes
380610681068.030.6930.7Muscarinic receptors--characterization, coupling and function. M P CaulfieldPharmacol Ther19937504306No
380710681068.029.1229.1Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu Rev Physiol19938466179No
380810681068.035.4235.4What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
380910681068.036.6936.7Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
381032031067.774.2624.8Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernán, B BrumbackEpidemiology200010955408Yes
381121351067.548.1224.1Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
381242681067.0218.2754.6National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. L N Robins, J E Helzer, J Croughan, K S RatcliffArch Gen Psychiatry19816260053Yes
381310671067.035.1235.1Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
381410671067.033.3133.3Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
381542671066.8106.5426.6An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
381663991066.5162.327.1Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
381721331066.557.8828.9Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
381810661066.029.5729.6Mitochondrial genetics: a paradigm for aging and degenerative diseases? D C WallaceScience19921533953Yes
381910661066.022.8122.8Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
382010661066.034.7534.8Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan St B T EvansAnnu Rev Psychol200818154502No
382110661066.031.7231.7Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
382221311065.538.4819.2Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ Mol Biol19704922220Yes
382321301065.060.4430.2Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
382410651065.027.0127.0Axonal growth-associated proteins. J H SkeneAnnu Rev Neurosci19892648946No
382510651065.018.9318.9Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. W KolchBiochem J200011023813No
382621291064.569.2734.6Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
382710641064.030.0430.0Epidemiology of cancer of the colon and rectum. D P BurkittCancer19715165022Yes
382831921064.0167.1655.7Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
382910641064.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DeeseJ Exp Psychol195913664879Yes
383010641064.032.0332.0Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
383110641064.049.149.1Cystic fibrosis. J Stuart ElbornLancet201627140670No
383221271063.574.3137.2The pathogenesis of atherosclerosis (first of two parts). R Ross, J A GlomsetN Engl J Med1976819830No
383321271063.579.8139.9A psychomotor stimulant theory of addiction. R A Wise, M A BozarthPsychol Rev19873317472No
383421271063.548.2724.1The significance of digital gene expression profiles. S Audic, J M ClaverieGenome Res19979331369Yes
383521271063.539.1719.6Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
383621271063.563.7631.9The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
383710631063.028.6628.7Microtubule formation in vitro in solutions containing low calcium concentrations. R C WeisenbergScience19724626639Yes
383810631063.032.7332.7Prevention of drug access to bacterial targets: permeability barriers and active efflux. H NikaidoScience19948153625No
383910631063.025.6825.7Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
384010631063.032.2632.3Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
384131881062.781.1427.0Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. M Piotto, V Saudek, V SklenárJ Biomol NMR19921490109Yes
384231881062.7149.0549.7Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
384353111062.2199.3739.9Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
384410621062.039.5139.5Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin Microbiol Rev19892644022No
384510621062.022.0222.0Oxidant signals and oxidative stress. Toren FinkelCurr Opin Cell Biol200312648682No
384610621062.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes
384721231061.561.6430.8Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
384821221061.00.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
384910611061.031.931.9Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
385010611061.00.00.0A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. R C LancefieldJ Exp Med193319870148Yes
385121211060.5104.7252.4Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
385210601060.029.2129.2Junctional intercellular communication: the cell-to-cell membrane channel. W R LoewensteinPhysiol Rev19816270711No
385310601060.021.0721.1Automated NMR structure calculation with CYANA. Peter GüntertMethods Mol Biol200415318003Yes
385410601060.033.8133.8Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
385521191059.540.0320.0Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev19979407023No
385621191059.545.0822.5InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
385721181059.082.6741.3Comparative aspects of the brain growth spurt. J Dobbing, J SandsEarly Hum Dev1979118862Yes
385810591059.024.6424.6Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
385910591059.036.9537.0A colorimetric method for estimating serum triglycerides. M J FletcherClin Chim Acta19685696963Yes
386010591059.030.2230.2Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. E M TanAdv Immunol19826182766No
386110591059.026.3326.3Skeletal complications of malignancy. R E ColemanCancer19979362426No
386210591059.024.5824.6Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
386310591059.029.7329.7Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
386410591059.029.5829.6Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
386531751058.376.1425.4Nitric oxide and macrophage function. J MacMicking, Q W Xie, C NathanAnnu Rev Immunol19979143691No
386610581058.030.3330.3Pathogenetic mechanisms of septic shock. J E ParrilloN Engl J Med19938479467No
386710581058.053.9954.0Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
386821151057.561.830.9The biochemistry of P-glycoprotein-mediated multidrug resistance. J A Endicott, V LingAnnu Rev Biochem19892570548No
386921151057.554.2327.1Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
387010571057.029.7529.8Hepatitis B virus. The major etiology of hepatocellular carcinoma. R P BeasleyCancer19882834034No
387142281057.0144.7336.2Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
387210571057.026.6726.7The potential environmental impact of engineered nanomaterials. Vicki L ColvinNat Biotechnol200314520401Yes
387310571057.030.4930.5Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
387410571057.030.3230.3Depression in the elderly. George S AlexopoulosLancet200515936426No
387510571057.030.7830.8Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
387642261056.581.220.3DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
387710561056.021.6521.6The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. D MetcalfNature19892469962No
387810561056.025.8325.8The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ Cell Biol19676061717Yes
387921121056.054.1527.1Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. M S Brown, J L GoldsteinAnnu Rev Biochem19836311077No
388010561056.029.829.8Determination of total protein. G L PetersonMethods Enzymol19836855607Yes
388110561056.025.025.0Sjögren's syndrome. Robert I FoxLancet200516039337No
388210551055.040.0540.0The ovariectomized rat model of postmenopausal bone loss. D N KaluBone Miner19911773131No
388310551055.023.9223.9The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. P A BaeuerleBiochim Biophys Acta19912018779No
388410551055.025.6225.6The granulocyte-macrophage colony-stimulating factors. D MetcalfScience19852990035No
388510551055.023.323.3Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. J Denis McGarryDiabetes200211756317No
388621101055.055.2327.6Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NuñezNat Rev Immunol201021088683No
388721081054.045.122.6The immunoglobulin superfamily--domains for cell surface recognition. A F Williams, A N BarclayAnnu Rev Immunol19883289571No
388821081054.031.8415.9The growth of mouse bone marrow cells in vitro. T R Bradley, D MetcalfAust J Exp Biol Med Sci19664164182Yes
388910541054.023.0423.0Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
389031611053.7218.372.8Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
389131601053.366.1822.1TGF-beta signalling from cell membrane to nucleus through SMAD proteins. C H Heldin, K Miyazono, P ten DijkeNature19979393997No
389210531053.024.3724.4Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. E M TanAdv Immunol19892646863No
389331591053.060.7920.3Genetic instabilities in human cancers. C Lengauer, K W Kinzler, B VogelsteinNature19989872311No
389410521052.048.8748.9Carcinoid tumors. An analysis of 2,837 cases. J D GodwinCancer19751157019Yes

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