Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	224594	224594.0	4913.95	4913.9	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	173870	173870.0	6868.45	6868.4	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	286062	71515.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	123889	61944.5	3076.47	1538.2	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	45349	45349.0	1391.93	1391.9	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	36974	36974.0	1191.63	1191.6	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	64456	32228.0	1931.46	965.7	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30237	30237.0	822.68	822.7	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	27980	27980.0	881.83	881.8	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	27932	27932.0	614.17	614.2	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	27350	27350.0	644.92	644.9	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
12	26112	26112.0	674.2	674.2	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
13	24851	24851.0	569.58	569.6	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
14	24502	24502.0	763.44	763.4	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
15	66690	22230.0	2447.42	815.8	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
16	66020	22006.7	1640.41	546.8	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
17	43345	21672.5	1339.31	669.7	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
18	20292	20292.0	204.7	204.7	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
19	40419	20209.5	1247.94	624.0	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
20	20097	20097.0	690.67	690.7	Density-functional exchange-energy approximation with correct asymptotic behavior.	A D Becke	Phys Rev A Gen Phys	1988	9900728	Yes
21	19623	19623.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
22	18471	18471.0	513.76	513.8	Projector augmented-wave method.	P E Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
23	36661	18330.5	1728.14	864.1	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	36608	18304.0	1517.9	759.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
25	53507	17835.7	1993.39	664.5	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
26	17444	17444.0	734.18	734.2	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
27	17392	17392.0	639.93	639.9	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
28	16999	16999.0	426.32	426.3	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
29	16752	16752.0	283.78	283.8	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
30	16717	16717.0	688.52	688.5	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
31	32550	16275.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
32	16207	16207.0	448.22	448.2	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
33	48062	16020.7	1770.32	590.1	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
34	31917	15958.5	1009.17	504.6	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
35	15925	15925.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
36	46800	15600.0	1383.2	461.1	Generalized Gradient Approximation Made Simple.	J P Perdew, K Burke, M Ernzerhof	Phys Rev Lett	1996	10062328	Yes
37	31152	15576.0	784.99	392.5	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
38	15468	15468.0	386.69	386.7	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
39	30563	15281.5	1220.33	610.2	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
40	45515	15171.7	1298.79	432.9	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
41	29917	14958.5	1119.04	559.5	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
42	14489	14489.0	564.62	564.6	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
43	42119	14039.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
44	13309	13309.0	673.62	673.6	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
45	64050	12810.0	1838.0	367.6	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
46	25334	12667.0	521.36	260.7	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
47	25259	12629.5	690.82	345.4	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	G Kresse, J Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
48	12629	12629.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
49	25159	12579.5	1029.43	514.7	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
50	12555	12555.0	318.96	319.0	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
51	12534	12534.0	399.61	399.6	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
52	12221	12221.0	561.63	561.6	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
53	12210	12210.0	368.56	368.6	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
54	12070	12070.0	137.94	137.9	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
55	24115	12057.5	650.4	325.2	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
56	36070	12023.3	1272.91	424.3	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	C Lee, W Yang, R G Parr	Phys Rev B Condens Matter	1988	9944570	Yes
57	23943	11971.5	521.8	260.9	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
58	11776	11776.0	387.6	387.6	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
59	35215	11738.3	1363.06	454.4	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
60	11315	11315.0	392.37	392.4	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
61	11286	11286.0	450.77	450.8	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
62	11095	11095.0	422.34	422.3	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
63	21975	10987.5	838.61	419.3	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
64	21563	10781.5	557.91	279.0	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
65	31934	10644.7	829.28	276.4	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
66	31815	10605.0	1067.95	356.0	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
67	21134	10567.0	454.55	227.3	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
68	10538	10538.0	364.65	364.6	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
69	21033	10516.5	460.8	230.4	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
70	20991	10495.5	895.54	447.8	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
71	41761	10440.2	1189.97	297.5	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
72	10296	10296.0	201.66	201.7	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
73	41059	10264.8	1582.05	395.5	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
74	10144	10144.0	454.88	454.9	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
75	10018	10018.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
76	19799	9899.5	372.57	186.3	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
77	9751	9751.0	417.22	417.2	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
78	9703	9703.0	273.38	273.4	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
79	9636	9636.0	199.22	199.2	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
80	9624	9624.0	254.94	254.9	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
81	19032	9516.0	491.26	245.6	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
82	9478	9478.0	317.97	318.0	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
83	9414	9414.0	273.37	273.4	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
84	9404	9404.0	248.85	248.8	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
85	9345	9345.0	269.48	269.5	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
86	9302	9302.0	240.67	240.7	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
87	37080	9270.0	1356.21	339.1	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
88	9255	9255.0	263.07	263.1	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
89	9174	9174.0	259.06	259.1	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
90	18301	9150.5	382.08	191.0	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
91	9041	9041.0	233.05	233.1	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
92	26812	8937.3	683.49	227.8	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
93	17801	8900.5	466.78	233.4	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
94	8895	8895.0	214.52	214.5	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
95	35540	8885.0	1147.59	286.9	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
96	53050	8841.7	3410.45	568.4	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
97	8782	8782.0	177.05	177.1	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
98	8762	8762.0	227.87	227.9	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
99	8759	8759.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
100	17358	8679.0	379.94	190.0	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
101	25730	8576.7	680.94	227.0	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
102	8555	8555.0	181.06	181.1	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
103	8495	8495.0	221.98	222.0	Canonical dynamics: Equilibrium phase-space distributions.	W G Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
104	8433	8433.0	356.89	356.9	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
105	8368	8368.0	412.65	412.6	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
106	8323	8323.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
107	8305	8305.0	216.98	217.0	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
108	8296	8296.0	244.78	244.8	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
109	24888	8296.0	1370.04	456.7	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
110	24402	8134.0	718.98	239.7	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
111	8094	8094.0	196.13	196.1	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
112	7951	7951.0	367.48	367.5	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
113	7873	7873.0	217.75	217.8	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
114	7856	7856.0	212.16	212.2	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
115	15675	7837.5	372.06	186.0	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
116	15656	7828.0	381.1	190.6	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
117	7798	7798.0	224.53	224.5	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
118	15594	7797.0	350.14	175.1	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
119	7786	7786.0	216.27	216.3	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
120	54229	7747.0	7344.73	1049.2	Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.	Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray	CA Cancer J Clin	2021	33538338	Yes
121	7730	7730.0	151.55	151.6	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
122	15286	7643.0	512.63	256.3	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
123	7638	7638.0	188.21	188.2	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
124	7635	7635.0	220.25	220.2	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
125	7634	7634.0	219.25	219.2	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
126	22792	7597.3	687.99	229.3	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
127	7582	7582.0	161.68	161.7	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
128	22607	7535.7	883.5	294.5	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
129	51662	7380.3	1329.81	190.0	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
130	7369	7369.0	232.8	232.8	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
131	7364	7364.0	124.11	124.1	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
132	7341	7341.0	242.66	242.7	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	J P Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
133	14628	7314.0	447.79	223.9	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
134	7305	7305.0	220.01	220.0	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
135	28913	7228.2	946.25	236.6	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
136	7062	7062.0	192.27	192.3	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
137	7042	7042.0	247.28	247.3	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
138	13913	6956.5	327.46	163.7	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
139	13763	6881.5	352.51	176.3	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
140	6837	6837.0	183.45	183.4	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
141	6722	6722.0	176.79	176.8	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
142	6705	6705.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
143	13384	6692.0	725.95	363.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
144	13180	6590.0	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
145	13152	6576.0	307.99	154.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
146	19689	6563.0	551.9	184.0	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
147	6561	6561.0	214.04	214.0	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
148	6549	6549.0	172.52	172.5	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
149	6542	6542.0	129.34	129.3	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
150	13023	6511.5	360.96	180.5	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
151	6511	6511.0	168.77	168.8	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
152	6493	6493.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
153	6404	6404.0	112.72	112.7	A Self-Rating Depression Scale.	W W Zung	Arch Gen Psychiatry	1965	14221692	Yes
154	6398	6398.0	128.99	129.0	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
155	6385	6385.0	150.28	150.3	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
156	6354	6354.0	134.97	135.0	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
157	12678	6339.0	351.77	175.9	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
158	12641	6320.5	505.78	252.9	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
159	12638	6319.0	431.56	215.8	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
160	6312	6312.0	216.07	216.1	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
161	12542	6271.0	844.39	422.2	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
162	6248	6248.0	135.99	136.0	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
163	6209	6209.0	146.2	146.2	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
164	6206	6206.0	142.41	142.4	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
165	6155	6155.0	143.66	143.7	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
166	6141	6141.0	114.63	114.6	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
167	12249	6124.5	436.27	218.1	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
168	18343	6114.3	912.76	304.3	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
169	6097	6097.0	270.99	271.0	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
170	18288	6096.0	641.49	213.8	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
171	6090	6090.0	149.03	149.0	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
172	6033	6033.0	152.25	152.2	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
173	6032	6032.0	151.93	151.9	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
174	6032	6032.0	145.58	145.6	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
175	23970	5992.5	774.6	193.7	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
176	11939	5969.5	290.46	145.2	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
177	5930	5930.0	136.72	136.7	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
178	5880	5880.0	278.09	278.1	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
179	11712	5856.0	268.95	134.5	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
180	11683	5841.5	318.26	159.1	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
181	11673	5836.5	253.81	126.9	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
182	5815	5815.0	76.16	76.2	The Environment And Disease: Association Or Causation?	A B Hill	Proc R Soc Med	1965	14283879	Yes
183	5812	5812.0	178.55	178.6	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
184	11517	5758.5	303.67	151.8	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
185	5703	5703.0	142.74	142.7	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
186	11403	5701.5	193.93	97.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
187	5695	5695.0	126.04	126.0	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
188	11380	5690.0	250.65	125.3	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
189	5686	5686.0	158.86	158.9	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
190	11278	5639.0	0.0	0.0	A series of normal stages in the development of the chick embryo.	V Hamburger, H L Hamilton	J Morphol	1951	24539719	Yes
191	5633	5633.0	184.34	184.3	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
192	5605	5605.0	177.22	177.2	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
193	5597	5597.0	137.75	137.8	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
194	5583	5583.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D Harman	J Gerontol	1956	13332224	Yes
195	5582	5582.0	106.79	106.8	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
196	5549	5549.0	221.23	221.2	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
197	5537	5537.0	92.65	92.7	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
198	5513	5513.0	119.35	119.3	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
199	5511	5511.0	92.73	92.7	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
200	10991	5495.5	254.74	127.4	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
201	10990	5495.0	364.25	182.1	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
202	16439	5479.7	494.17	164.7	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
203	10951	5475.5	231.44	115.7	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
204	10948	5474.0	920.16	460.1	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
205	10926	5463.0	287.18	143.6	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
206	10913	5456.5	277.83	138.9	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
207	5420	5420.0	164.85	164.8	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
208	5358	5358.0	121.43	121.4	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
209	10704	5352.0	300.1	150.1	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
210	5336	5336.0	140.34	140.3	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
211	5335	5335.0	136.77	136.8	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
212	5328	5328.0	157.58	157.6	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
213	5305	5305.0	201.65	201.7	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
214	5299	5299.0	134.93	134.9	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
215	5294	5294.0	102.76	102.8	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
216	10587	5293.5	495.29	247.6	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
217	26453	5290.6	714.32	142.9	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
218	10578	5289.0	230.72	115.4	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
219	15864	5288.0	594.18	198.1	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
220	10576	5288.0	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L Hodgkin, A F Huxley	J Physiol	1952	12991237	Yes
221	5280	5280.0	127.53	127.5	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
222	5265	5265.0	142.82	142.8	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
223	5260	5260.0	151.76	151.8	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
224	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J Scheidegger	Int Arch Allergy Appl Immunol	1955	13262900	Yes
225	5213	5213.0	53.48	53.5	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P Lauren	Acta Pathol Microbiol Scand	1965	14320675	Yes
226	15601	5200.3	384.28	128.1	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
227	5200	5200.0	188.78	188.8	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
228	5191	5191.0	66.12	66.1	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
229	31119	5186.5	1086.18	181.0	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
230	20658	5164.5	524.58	131.1	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
231	10300	5150.0	365.26	182.6	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
232	5122	5122.0	124.35	124.3	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
233	5104	5104.0	101.67	101.7	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
234	10201	5100.5	241.95	121.0	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
235	5100	5100.0	102.07	102.1	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
236	10198	5099.0	270.51	135.3	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
237	5083	5083.0	197.37	197.4	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
238	5077	5077.0	186.9	186.9	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
239	10137	5068.5	219.21	109.6	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
240	4991	4991.0	231.66	231.7	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
241	14962	4987.3	1008.49	336.2	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
242	14939	4979.7	539.82	179.9	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
243	24851	4970.2	1075.38	215.1	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
244	9907	4953.5	235.85	117.9	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
245	4951	4951.0	129.38	129.4	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
246	4923	4923.0	110.88	110.9	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
247	4910	4910.0	179.94	179.9	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
248	4909	4909.0	140.42	140.4	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
249	14703	4901.0	1236.77	412.3	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
250	9797	4898.5	351.07	175.5	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
251	14613	4871.0	392.98	131.0	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
252	14598	4866.0	577.18	192.4	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
253	4849	4849.0	147.41	147.4	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
254	4846	4846.0	97.56	97.6	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
255	24162	4832.4	410.17	82.0	An inventory for measuring depression.	A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh	Arch Gen Psychiatry	1961	13688369	Yes
256	4828	4828.0	90.06	90.1	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
257	9651	4825.5	159.82	79.9	Functional Evaluation: The Barthel Index.	F I Mahoney, D W Barthel	Md State Med J	1965	14258950	Yes
258	14447	4815.7	357.03	119.0	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
259	9619	4809.5	260.03	130.0	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
260	14396	4798.7	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G Gornall, C J Bardawill, M M David	J Biol Chem	1949	18110453	Yes
261	9596	4798.0	175.22	87.6	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
262	4788	4788.0	59.75	59.8	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M Rodbell	J Biol Chem	1964	14169133	Yes
263	4781	4781.0	107.14	107.1	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
264	9554	4777.0	324.48	162.2	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
265	4766	4766.0	104.77	104.8	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
266	9516	4758.0	218.14	109.1	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
267	9504	4752.0	158.27	79.1	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
268	9425	4712.5	237.16	118.6	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
269	9402	4701.0	386.94	193.5	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
270	4700	4700.0	156.95	156.9	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
271	4691	4691.0	203.52	203.5	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
272	14059	4686.3	484.9	161.6	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
273	14058	4686.0	306.38	102.1	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
274	4674	4674.0	129.91	129.9	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
275	4673	4673.0	102.83	102.8	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
276	4672	4672.0	76.21	76.2	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V Born	Nature	1962	13871375	Yes
277	9342	4671.0	254.66	127.3	Ab initio molecular dynamics for liquid metals.	G Kresse, J Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
278	4653	4653.0	40.41	40.4	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L Hayflick	Exp Cell Res	1965	14315085	Yes
279	4641	4641.0	120.3	120.3	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
280	4641	4641.0	102.91	102.9	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
281	18545	4636.2	532.63	133.2	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
282	9267	4633.5	337.83	168.9	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
283	13894	4631.3	609.28	203.1	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
284	18469	4617.2	299.28	74.8	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L Ellman, K D Courtney, V Andres, R M Feather-Stone	Biochem Pharmacol	1961	13726518	Yes
285	9143	4571.5	139.96	70.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
286	4571	4571.0	93.57	93.6	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
287	9141	4570.5	202.74	101.4	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
288	13632	4544.0	445.4	148.5	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
289	4521	4521.0	140.88	140.9	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
290	4520	4520.0	96.79	96.8	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
291	13553	4517.7	482.52	160.8	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
292	13512	4504.0	430.86	143.6	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
293	17979	4494.8	538.8	134.7	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
294	4494	4494.0	114.01	114.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
295	8985	4492.5	214.68	107.3	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
296	4487	4487.0	102.81	102.8	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
297	8953	4476.5	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T Litchfield, F Wilcoxon	J Pharmacol Exp Ther	1949	18152921	Yes
298	4476	4476.0	106.26	106.3	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
299	4475	4475.0	90.25	90.2	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
300	26751	4458.5	919.05	153.2	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
301	4437	4437.0	107.62	107.6	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
302	13306	4435.3	571.3	190.4	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
303	8865	4432.5	237.13	118.6	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
304	4406	4406.0	90.39	90.4	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
305	17587	4396.8	550.39	137.6	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
306	4388	4388.0	84.98	85.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
307	8771	4385.5	202.74	101.4	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
308	8767	4383.5	161.07	80.5	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
309	8762	4381.0	219.17	109.6	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
310	8754	4377.0	325.58	162.8	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
311	4376	4376.0	83.35	83.3	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
312	4364	4364.0	158.89	158.9	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
313	8714	4357.0	251.64	125.8	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
314	4351	4351.0	221.51	221.5	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
315	26060	4343.3	951.38	158.6	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
316	8678	4339.0	358.62	179.3	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
317	13011	4337.0	624.98	208.3	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
318	4334	4334.0	111.74	111.7	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
319	8643	4321.5	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H Kellgren, J S Lawrence	Ann Rheum Dis	1957	13498604	Yes
320	4319	4319.0	101.17	101.2	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
321	4300	4300.0	128.51	128.5	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
322	12883	4294.3	746.62	248.9	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
323	4293	4293.0	91.11	91.1	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
324	8581	4290.5	124.47	62.2	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M Hunter, F C Greenwood	Nature	1962	14450081	Yes
325	4284	4284.0	160.38	160.4	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
326	4272	4272.0	113.29	113.3	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
327	4270	4270.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B De B Weir	J Physiol	1949	15394301	Yes
328	4266	4266.0	92.34	92.3	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
329	8521	4260.5	312.59	156.3	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
330	29707	4243.9	652.82	93.3	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
331	4242	4242.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M Abercrombie	Anat Rec	1946	21015608	Yes
332	25417	4236.2	829.44	138.2	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
333	4236	4236.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T Nash	Biochem J	1953	13105648	Yes
334	4235	4235.0	87.39	87.4	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
335	4235	4235.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
336	4235	4235.0	199.93	199.9	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
337	4226	4226.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H Eagle	Science	1959	13675766	Yes
338	4220	4220.0	109.67	109.7	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
339	4216	4216.0	93.82	93.8	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
340	4212	4212.0	91.04	91.0	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
341	4206	4206.0	75.86	75.9	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
342	12617	4205.7	467.9	156.0	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
343	4196	4196.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P Dole	J Clin Invest	1956	13286333	Yes
344	4186	4186.0	92.75	92.8	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
345	4183	4183.0	87.0	87.0	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
346	4182	4182.0	109.11	109.1	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
347	8359	4179.5	222.69	111.3	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
348	8344	4172.0	223.42	111.7	Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii.	Daniel E Voth, Robert A Heinzen	Cell Microbiol	2007	17381428	No
349	4167	4167.0	129.44	129.4	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
350	12493	4164.3	469.86	156.6	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
351	37463	4162.6	945.83	105.1	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
352	16629	4157.2	622.3	155.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
353	4152	4152.0	50.54	50.5	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
354	4146	4146.0	152.21	152.2	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
355	4144	4144.0	173.27	173.3	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
356	8281	4140.5	177.6	88.8	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
357	4136	4136.0	0.0	0.0	The determination of enzyme inhibitor constants.	M Dixon	Biochem J	1953	13093635	Yes
358	8252	4126.0	263.2	131.6	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
359	4094	4094.0	128.32	128.3	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
360	8180	4090.0	209.21	104.6	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
361	4086	4086.0	168.97	169.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
362	4084	4084.0	84.77	84.8	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
363	4061	4061.0	127.63	127.6	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
364	4054	4054.0	112.83	112.8	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
365	4042	4042.0	79.12	79.1	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
366	4038	4038.0	136.09	136.1	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
367	12106	4035.3	614.49	204.8	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
368	4032	4032.0	109.53	109.5	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
369	8041	4020.5	222.75	111.4	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
370	4003	4003.0	103.49	103.5	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
371	3995	3995.0	70.08	70.1	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
372	15975	3993.8	580.73	145.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
373	3989	3989.0	107.21	107.2	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
374	3974	3974.0	100.42	100.4	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
375	3973	3973.0	115.9	115.9	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	D Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
376	3972	3972.0	128.38	128.4	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
377	3971	3971.0	97.44	97.4	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
378	11900	3966.7	303.96	101.3	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
379	3964	3964.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L Watson	J Biophys Biochem Cytol	1958	13563554	Yes
380	7923	3961.5	149.7	74.8	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
381	7912	3956.0	194.25	97.1	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
382	7865	3932.5	200.02	100.0	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
383	3931	3931.0	104.51	104.5	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
384	3926	3926.0	85.32	85.3	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
385	7846	3923.0	219.14	109.6	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
386	3920	3920.0	103.93	103.9	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
387	3916	3916.0	84.04	84.0	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
388	3911	3911.0	64.3	64.3	Disc Electrophoresis. I. Background And Theory.	L Ornstein	Ann N Y Acad Sci	1964	14240533	Yes
389	3907	3907.0	120.52	120.5	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
390	3907	3907.0	103.06	103.1	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
391	11713	3904.3	315.35	105.1	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
392	3889	3889.0	80.38	80.4	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
393	7773	3886.5	146.57	73.3	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
394	19429	3885.8	755.33	151.1	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
395	15539	3884.8	360.77	90.2	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
396	3883	3883.0	109.74	109.7	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
397	3878	3878.0	119.3	119.3	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
398	7756	3878.0	258.46	129.2	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
399	3856	3856.0	94.73	94.7	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
400	3852	3852.0	125.14	125.1	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
401	3848	3848.0	127.67	127.7	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
402	3847	3847.0	98.06	98.1	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
403	7676	3838.0	306.42	153.2	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
404	3831	3831.0	95.79	95.8	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
405	3830	3830.0	101.64	101.6	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
406	3828	3828.0	96.75	96.8	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
407	3818	3818.0	90.85	90.8	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
408	3815	3815.0	84.53	84.5	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
409	3812	3812.0	103.12	103.1	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
410	3802	3802.0	110.1	110.1	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
411	3800	3800.0	80.81	80.8	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
412	3798	3798.0	74.17	74.2	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
413	7590	3795.0	167.75	83.9	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
414	3792	3792.0	80.29	80.3	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
415	3792	3792.0	117.26	117.3	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
416	3791	3791.0	108.61	108.6	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
417	3784	3784.0	126.86	126.9	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
418	15108	3777.0	483.65	120.9	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
419	7549	3774.5	189.77	94.9	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
420	3772	3772.0	87.37	87.4	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
421	3769	3769.0	119.05	119.0	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
422	3764	3764.0	77.43	77.4	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
423	7528	3764.0	209.04	104.5	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
424	7522	3761.0	181.22	90.6	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
425	3760	3760.0	108.81	108.8	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
426	3757	3757.0	154.6	154.6	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
427	3749	3749.0	89.19	89.2	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
428	7495	3747.5	180.15	90.1	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
429	3746	3746.0	107.25	107.2	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
430	11227	3742.3	215.08	71.7	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
431	3735	3735.0	169.18	169.2	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
432	14891	3722.8	383.76	95.9	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
433	3703	3703.0	61.47	61.5	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
434	3703	3703.0	93.66	93.7	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
435	7404	3702.0	253.95	127.0	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
436	3690	3690.0	66.29	66.3	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
437	3682	3682.0	106.02	106.0	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
438	3681	3681.0	88.93	88.9	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
439	7356	3678.0	184.47	92.2	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
440	3677	3677.0	85.79	85.8	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
441	3676	3676.0	103.26	103.3	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
442	7350	3675.0	161.53	80.8	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
443	3668	3668.0	103.22	103.2	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
444	3640	3640.0	100.66	100.7	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
445	3640	3640.0	94.83	94.8	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
446	7234	3617.0	183.22	91.6	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
447	21686	3614.3	973.62	162.3	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
448	3602	3602.0	108.0	108.0	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
449	3602	3602.0	84.63	84.6	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
450	10737	3579.0	258.68	86.2	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
451	7155	3577.5	180.69	90.3	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
452	3576	3576.0	74.76	74.8	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
453	3559	3559.0	84.94	84.9	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
454	3553	3553.0	108.8	108.8	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
455	3550	3550.0	97.02	97.0	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
456	3540	3540.0	70.68	70.7	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
457	3537	3537.0	164.12	164.1	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
458	10605	3535.0	260.42	86.8	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
459	17633	3526.6	1202.77	240.6	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
460	3526	3526.0	80.0	80.0	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
461	3525	3525.0	109.37	109.4	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
462	3522	3522.0	66.7	66.7	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
463	7044	3522.0	126.91	63.5	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
464	3516	3516.0	54.17	54.2	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
465	7030	3515.0	145.06	72.5	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
466	3515	3515.0	104.9	104.9	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
467	3511	3511.0	113.04	113.0	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
468	7020	3510.0	358.29	179.1	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
469	3508	3508.0	80.02	80.0	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
470	17535	3507.0	496.08	99.2	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
471	7014	3507.0	83.26	41.6	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H Hubel, T N Wiesel	J Physiol	1962	14449617	Yes
472	3504	3504.0	90.91	90.9	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
473	3501	3501.0	56.74	56.7	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
474	3501	3501.0	86.49	86.5	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
475	3496	3496.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A Miller	Psychol Rev	1956	13310704	Yes
476	3490	3490.0	128.39	128.4	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
477	3488	3488.0	58.94	58.9	Statistical estimations in enzyme kinetics.	G N Wilkinson	Biochem J	1961	13785321	Yes
478	3481	3481.0	84.84	84.8	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
479	3476	3476.0	51.93	51.9	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F Woessner	Arch Biochem Biophys	1961	13786180	Yes
480	3473	3473.0	80.83	80.8	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
481	10418	3472.7	392.26	130.8	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
482	3469	3469.0	86.38	86.4	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
483	3457	3457.0	134.97	135.0	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
484	3455	3455.0	533.68	533.7	Hallmarks of Cancer: New Dimensions.	Douglas Hanahan	Cancer Discov	2022	35022204	No
485	3454	3454.0	154.88	154.9	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
486	3452	3452.0	102.48	102.5	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
487	6901	3450.5	135.58	67.8	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
488	3449	3449.0	93.77	93.8	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
489	3443	3443.0	86.84	86.8	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
490	3442	3442.0	74.6	74.6	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
491	3441	3441.0	110.3	110.3	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
492	6872	3436.0	162.63	81.3	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
493	10279	3426.3	448.36	149.5	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
494	3416	3416.0	59.98	60.0	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
495	6801	3400.5	172.64	86.3	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
496	3388	3388.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W Kauzmann	Adv Protein Chem	1959	14404936	Yes
497	3386	3386.0	82.53	82.5	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
498	6772	3386.0	184.93	92.5	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
499	10139	3379.7	98.26	32.8	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C Greenwood, W M Hunter, J S Glover	Biochem J	1963	14097352	Yes
500	6749	3374.5	159.63	79.8	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
501	10109	3369.7	358.86	119.6	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
502	6737	3368.5	207.57	103.8	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
503	6727	3363.5	128.64	64.3	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
504	3363	3363.0	76.44	76.4	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
505	3355	3355.0	94.72	94.7	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
506	3351	3351.0	68.64	68.6	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
507	6670	3335.0	141.99	71.0	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
508	3327	3327.0	68.01	68.0	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
509	3317	3317.0	79.88	79.9	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
510	3302	3302.0	83.86	83.9	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
511	3300	3300.0	89.34	89.3	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
512	3300	3300.0	64.23	64.2	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
513	3300	3300.0	47.43	47.4	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A Yphantis	Biochemistry	1964	14155091	Yes
514	6587	3293.5	207.04	103.5	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
515	6581	3290.5	157.68	78.8	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
516	6565	3282.5	204.82	102.4	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
517	6553	3276.5	217.04	108.5	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
518	3275	3275.0	66.82	66.8	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
519	6550	3275.0	178.29	89.1	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
520	3270	3270.0	60.05	60.0	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
521	3269	3269.0	86.96	87.0	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
522	3260	3260.0	116.74	116.7	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
523	3257	3257.0	109.86	109.9	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
524	3257	3257.0	73.66	73.7	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
525	13025	3256.2	301.22	75.3	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
526	3255	3255.0	76.35	76.3	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
527	6497	3248.5	195.68	97.8	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
528	3246	3246.0	103.89	103.9	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
529	29206	3245.1	626.76	69.6	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
530	3239	3239.0	93.58	93.6	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
531	3236	3236.0	64.02	64.0	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
532	3232	3232.0	98.1	98.1	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
533	3227	3227.0	69.39	69.4	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
534	3219	3219.0	67.57	67.6	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
535	3218	3218.0	84.33	84.3	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
536	3206	3206.0	65.3	65.3	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
537	6399	3199.5	199.59	99.8	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
538	6397	3198.5	154.0	77.0	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
539	3194	3194.0	66.22	66.2	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
540	6353	3176.5	184.91	92.5	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
541	3172	3172.0	110.02	110.0	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
542	9514	3171.3	231.36	77.1	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
543	3166	3166.0	78.37	78.4	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
544	6319	3159.5	133.1	66.5	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
545	3156	3156.0	90.85	90.8	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
546	12618	3154.5	477.73	119.4	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
547	3152	3152.0	96.58	96.6	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
548	6290	3145.0	206.49	103.2	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
549	3145	3145.0	78.39	78.4	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
550	3145	3145.0	84.61	84.6	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
551	6285	3142.5	54.06	27.0	The serial cultivation of human diploid cell strains.	L Hayflick, P S Moorhead	Exp Cell Res	1961	13905658	Yes
552	9422	3140.7	266.14	88.7	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
553	6279	3139.5	152.45	76.2	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
554	6279	3139.5	101.92	51.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
555	3139	3139.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O Ouchterlony	Prog Allergy	1958	13578996	Yes
556	3138	3138.0	74.07	74.1	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
557	12545	3136.2	456.58	114.1	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
558	3135	3135.0	121.66	121.7	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
559	3135	3135.0	26.79	26.8	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F Lyon	Nature	1961	13764598	Yes
560	3133	3133.0	65.65	65.7	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
561	3128	3128.0	65.88	65.9	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
562	3117	3117.0	89.76	89.8	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
563	6232	3116.0	163.67	81.8	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
564	9339	3113.0	194.22	64.7	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
565	6220	3110.0	156.68	78.3	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
566	3106	3106.0	115.69	115.7	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
567	6207	3103.5	266.62	133.3	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
568	3103	3103.0	124.9	124.9	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
569	3100	3100.0	76.02	76.0	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
570	6192	3096.0	196.0	98.0	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
571	3095	3095.0	88.92	88.9	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
572	9280	3093.3	311.43	103.8	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
573	21653	3093.3	802.99	114.7	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
574	3091	3091.0	89.37	89.4	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
575	3089	3089.0	106.03	106.0	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
576	6164	3082.0	108.53	54.3	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
577	3082	3082.0	72.66	72.7	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
578	6164	3082.0	136.36	68.2	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
579	6149	3074.5	180.5	90.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
580	27631	3070.1	872.37	96.9	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
581	3069	3069.0	85.82	85.8	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
582	6125	3062.5	188.3	94.2	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
583	3058	3058.0	65.13	65.1	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
584	24430	3053.8	527.54	65.9	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
585	3051	3051.0	103.01	103.0	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
586	3049	3049.0	56.81	56.8	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
587	3042	3042.0	70.49	70.5	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
588	3042	3042.0	48.81	48.8	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S Hakomori	J Biochem	1964	14135466	Yes
589	6072	3036.0	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S Reitman, S Frankel	Am J Clin Pathol	1957	13458125	Yes
590	3035	3035.0	136.63	136.6	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
591	3031	3031.0	72.64	72.6	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
592	6052	3026.0	224.82	112.4	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
593	3025	3025.0	102.73	102.7	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
594	6046	3023.0	143.21	71.6	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
595	9059	3019.7	170.67	56.9	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
596	12068	3017.0	284.48	71.1	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
597	9023	3007.7	176.93	59.0	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
598	33083	3007.5	688.41	62.6	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
599	3007	3007.0	0.0	0.0	A study of fixation for electron microscopy.	G E Palade	J Exp Med	1952	14927794	Yes
600	8988	2996.0	206.45	68.8	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
601	11970	2992.5	527.63	131.9	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
602	5983	2991.5	134.8	67.4	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
603	2984	2984.0	58.92	58.9	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
604	2982	2982.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I Seldinger	Acta radiol	1953	13057644	Yes
605	2980	2980.0	90.38	90.4	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
606	2978	2978.0	54.77	54.8	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
607	2977	2977.0	73.48	73.5	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
608	2975	2975.0	68.81	68.8	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
609	2975	2975.0	70.01	70.0	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
610	8920	2973.3	289.73	96.6	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
611	2973	2973.0	52.91	52.9	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
612	5943	2971.5	124.88	62.4	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
613	2967	2967.0	94.39	94.4	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
614	5930	2965.0	125.23	62.6	Emergence of scaling in random networks.	AL Barabasi, R Albert	Science	1999	10521342	Yes
615	8889	2963.0	447.65	149.2	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
616	5924	2962.0	153.21	76.6	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
617	2961	2961.0	91.34	91.3	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
618	2955	2955.0	66.39	66.4	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
619	8829	2943.0	241.95	80.6	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
620	5880	2940.0	184.63	92.3	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
621	2937	2937.0	66.07	66.1	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
622	2935	2935.0	102.62	102.6	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
623	5869	2934.5	236.64	118.3	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
624	8784	2928.0	202.52	67.5	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
625	2920	2920.0	47.3	47.3	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L Horn	Psychometrika	1965	14306381	Yes
626	5839	2919.5	122.06	61.0	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
627	11666	2916.5	342.33	85.6	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
628	2916	2916.0	43.91	43.9	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
629	2911	2911.0	0.0	0.0	The genetical structure of populations.	S Wright	Ann Eugen	1951	24540312	Yes
630	2908	2908.0	68.69	68.7	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
631	5816	2908.0	153.42	76.7	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
632	2901	2901.0	29.31	29.3	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P Mitchell	Nature	1961	13771349	Yes
633	8693	2897.7	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J Havel, H A Eder, J H Bragdon	J Clin Invest	1955	13252080	Yes
634	2897	2897.0	70.64	70.6	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
635	5790	2895.0	161.84	80.9	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
636	2894	2894.0	122.3	122.3	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
637	2892	2892.0	61.89	61.9	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
638	5779	2889.5	177.9	89.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
639	2889	2889.0	67.33	67.3	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
640	2887	2887.0	107.1	107.1	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
641	2886	2886.0	59.69	59.7	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
642	2880	2880.0	85.97	86.0	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
643	5754	2877.0	126.61	63.3	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
644	2872	2872.0	50.46	50.5	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A Gehan	Biometrika	1965	14341275	Yes
645	2866	2866.0	50.74	50.7	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
646	2863	2863.0	56.52	56.5	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
647	2863	2863.0	55.75	55.8	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
648	2861	2861.0	56.1	56.1	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
649	2861	2861.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C Schneider	J Biol Chem	1945	21005736	Yes
650	2860	2860.0	95.51	95.5	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
651	2858	2858.0	52.34	52.3	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
652	2858	2858.0	63.71	63.7	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
653	11432	2858.0	1328.6	332.1	Cancer Statistics, 2021.	Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal	CA Cancer J Clin	2021	33433946	Yes
654	2856	2856.0	71.99	72.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
655	2856	2856.0	0.0	0.0	Notes on sugar determination.	M Smogyi	J Biol Chem	1952	14938350	Yes
656	5710	2855.0	248.25	124.1	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
657	2852	2852.0	153.63	153.6	Hepatocellular Carcinoma.	Augusto Villanueva	N Engl J Med	2019	30970190	No
658	2850	2850.0	61.03	61.0	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
659	8546	2848.7	246.9	82.3	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
660	2836	2836.0	93.76	93.8	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
661	2836	2836.0	0.0	0.0	A study of the adrenotropic receptors.	R P Ahlquist	Am J Physiol	1948	18882199	Yes
662	8487	2829.0	364.41	121.5	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
663	5658	2829.0	268.82	134.4	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
664	2828	2828.0	85.62	85.6	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
665	2828	2828.0	82.21	82.2	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
666	5644	2822.0	143.44	71.7	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
667	2822	2822.0	66.59	66.6	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
668	8464	2821.3	207.07	69.0	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
669	2819	2819.0	53.7	53.7	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
670	8450	2816.7	247.48	82.5	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
671	5629	2814.5	173.58	86.8	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
672	2814	2814.0	121.4	121.4	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
673	2809	2809.0	126.47	126.5	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
674	5618	2809.0	112.9	56.5	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
675	2809	2809.0	78.74	78.7	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
676	5611	2805.5	192.93	96.5	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
677	2805	2805.0	47.64	47.6	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
678	2803	2803.0	90.33	90.3	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
679	5600	2800.0	134.69	67.3	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
680	5600	2800.0	152.53	76.3	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
681	5586	2793.0	126.6	63.3	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
682	8379	2793.0	190.21	63.4	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
683	5584	2792.0	185.45	92.7	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
684	2791	2791.0	70.02	70.0	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
685	5579	2789.5	77.86	38.9	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G Martin, B N Ames	J Biol Chem	1961	13767412	Yes
686	2789	2789.0	70.54	70.5	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
687	8365	2788.3	281.37	93.8	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
688	5575	2787.5	109.97	55.0	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
689	2787	2787.0	69.83	69.8	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
690	11134	2783.5	295.56	73.9	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
691	2780	2780.0	65.08	65.1	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
692	2780	2780.0	112.34	112.3	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
693	2778	2778.0	109.18	109.2	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
694	2776	2776.0	80.44	80.4	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
695	5545	2772.5	199.91	100.0	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
696	2772	2772.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
697	11084	2771.0	335.43	83.9	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
698	5529	2764.5	152.54	76.3	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
699	5527	2763.5	130.41	65.2	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
700	5519	2759.5	161.24	80.6	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
701	5517	2758.5	127.65	63.8	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
702	5515	2757.5	133.69	66.8	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
703	2757	2757.0	82.78	82.8	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
704	5502	2751.0	91.18	45.6	A modified uronic acid carbazole reaction.	T Bitter, H M Muir	Anal Biochem	1962	13971270	Yes
705	5496	2748.0	185.96	93.0	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
706	2746	2746.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L Svennerholm	Biochim Biophys Acta	1957	13436486	Yes
707	2744	2744.0	66.03	66.0	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
708	2742	2742.0	72.57	72.6	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
709	2738	2738.0	70.51	70.5	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
710	2738	2738.0	58.94	58.9	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
711	2736	2736.0	61.67	61.7	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
712	5470	2735.0	166.83	83.4	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
713	2733	2733.0	53.01	53.0	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
714	5444	2722.0	107.52	53.8	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
715	8142	2714.0	175.36	58.5	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
716	2707	2707.0	85.22	85.2	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
717	2705	2705.0	60.93	60.9	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
718	2704	2704.0	62.56	62.6	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
719	16216	2702.7	361.26	60.2	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
720	5402	2701.0	185.12	92.6	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
721	2699	2699.0	65.1	65.1	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
722	5394	2697.0	158.56	79.3	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
723	10778	2694.5	316.97	79.2	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
724	2687	2687.0	59.5	59.5	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
725	8058	2686.0	199.31	66.4	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
726	2686	2686.0	104.66	104.7	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
727	2685	2685.0	23.47	23.5	Satellite cell of skeletal muscle fibers.	A Mauro	J Biophys Biochem Cytol	1961	13768451	Yes
728	10734	2683.5	227.44	56.9	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
729	2682	2682.0	60.23	60.2	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
730	2682	2682.0	82.68	82.7	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
731	5357	2678.5	164.66	82.3	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
732	2675	2675.0	51.47	51.5	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
733	2663	2663.0	60.82	60.8	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
734	5325	2662.5	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D Watson, F H Crick	Nature	1953	13054692	Yes
735	2660	2660.0	62.1	62.1	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
736	5319	2659.5	165.13	82.6	Accurate and simple analytic representation of the electron-gas correlation energy.	J P Perdew, Y Wang	Phys Rev B Condens Matter	1992	10001404	Yes
737	2658	2658.0	83.31	83.3	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
738	2646	2646.0	59.5	59.5	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
739	5286	2643.0	210.36	105.2	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
740	2641	2641.0	82.05	82.0	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
741	2638	2638.0	107.04	107.0	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
742	2636	2636.0	75.45	75.5	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
743	2632	2632.0	90.38	90.4	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
744	5260	2630.0	107.91	54.0	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
745	2624	2624.0	98.28	98.3	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
746	2623	2623.0	105.93	105.9	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
747	2623	2623.0	65.26	65.3	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
748	7859	2619.7	204.94	68.3	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
749	5237	2618.5	136.9	68.5	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
750	5236	2618.0	101.8	50.9	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
751	2617	2617.0	132.27	132.3	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
752	5224	2612.0	117.36	58.7	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
753	2612	2612.0	122.43	122.4	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
754	5222	2611.0	0.0	0.0	Some quantitative uses of drug antagonists.	O Arunlakshana, H O Schild	Br J Pharmacol Chemother	1959	13651579	Yes
755	2609	2609.0	72.47	72.5	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
756	5216	2608.0	103.04	51.5	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J Silness, H Loe	Acta Odontol Scand	1964	14158464	Yes
757	5213	2606.5	180.61	90.3	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
758	2606	2606.0	72.76	72.8	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
759	2600	2600.0	50.74	50.7	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
760	2599	2599.0	56.53	56.5	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
761	2592	2592.0	73.32	73.3	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
762	5179	2589.5	73.53	36.8	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
763	2588	2588.0	127.2	127.2	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
764	2587	2587.0	55.33	55.3	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
765	2586	2586.0	53.65	53.6	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
766	2585	2585.0	52.56	52.6	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
767	5169	2584.5	167.78	83.9	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
768	5167	2583.5	127.31	63.7	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
769	2582	2582.0	61.62	61.6	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
770	2579	2579.0	80.62	80.6	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
771	2577	2577.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
772	5151	2575.5	160.21	80.1	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
773	2575	2575.0	71.18	71.2	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
774	2572	2572.0	68.83	68.8	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
775	2572	2572.0	73.33	73.3	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
776	2568	2568.0	61.84	61.8	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
777	2561	2561.0	79.26	79.3	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
778	2560	2560.0	36.04	36.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
779	5112	2556.0	158.96	79.5	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
780	2555	2555.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R Porter	Biochem J	1959	14434282	Yes
781	2546	2546.0	83.04	83.0	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
782	2545	2545.0	67.13	67.1	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
783	2545	2545.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O Smithies	Biochem J	1955	13276348	Yes
784	5089	2544.5	223.98	112.0	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
785	2543	2543.0	54.92	54.9	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
786	10138	2534.5	1929.31	482.3	Cancer statistics, 2022.	Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal	CA Cancer J Clin	2022	35020204	Yes
787	5068	2534.0	275.93	138.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
788	2533	2533.0	51.09	51.1	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
789	2533	2533.0	61.85	61.9	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
790	5061	2530.5	116.28	58.1	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
791	2530	2530.0	28.17	28.2	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S Boyden	J Exp Med	1962	13872176	Yes
792	7590	2530.0	199.04	66.3	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
793	2523	2523.0	74.1	74.1	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
794	2513	2513.0	77.17	77.2	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
795	7535	2511.7	204.34	68.1	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
796	7534	2511.3	187.3	62.4	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
797	2509	2509.0	54.97	55.0	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
798	5012	2506.0	129.56	64.8	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
799	10021	2505.2	400.88	100.2	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
800	5010	2505.0	100.25	50.1	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
801	2503	2503.0	44.91	44.9	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
802	2503	2503.0	62.01	62.0	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
803	7498	2499.3	215.44	71.8	GSVA: gene set variation analysis for microarray and RNA-seq data.	Sonja Hänzelmann, Robert Castelo, Justin Guinney	BMC Bioinformatics	2013	23323831	Yes
804	7487	2495.7	193.65	64.5	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
805	4983	2491.5	181.26	90.6	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
806	4982	2491.0	147.89	73.9	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
807	4979	2489.5	141.46	70.7	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
808	4974	2487.0	123.38	61.7	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
809	9936	2484.0	510.68	127.7	fastp: an ultra-fast all-in-one FASTQ preprocessor.	Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu	Bioinformatics	2018	30423086	Yes
810	4966	2483.0	119.73	59.9	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
811	4956	2478.0	96.24	48.1	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
812	2472	2472.0	111.94	111.9	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
813	2470	2470.0	46.96	47.0	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
814	2470	2470.0	92.19	92.2	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
815	2466	2466.0	61.91	61.9	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
816	2461	2461.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S Lennox	Virology	1955	13267987	Yes
817	4916	2458.0	130.77	65.4	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
818	4915	2457.5	142.01	71.0	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
819	2456	2456.0	53.51	53.5	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
820	7348	2449.3	209.14	69.7	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
821	2445	2445.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M Fitts	J Exp Psychol	1954	13174710	Yes
822	4890	2445.0	103.7	51.9	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
823	4887	2443.5	108.42	54.2	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
824	2442	2442.0	47.28	47.3	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
825	2441	2441.0	78.25	78.2	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
826	2441	2441.0	57.87	57.9	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
827	2441	2441.0	110.58	110.6	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
828	2439	2439.0	65.5	65.5	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
829	2438	2438.0	54.09	54.1	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
830	2438	2438.0	58.52	58.5	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
831	9743	2435.8	253.42	63.4	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
832	2434	2434.0	82.31	82.3	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
833	4863	2431.5	68.87	34.4	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H Loe, J Silness	Acta Odontol Scand	1963	14121956	Yes
834	2431	2431.0	130.74	130.7	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
835	2430	2430.0	61.36	61.4	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
836	4859	2429.5	120.91	60.5	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
837	9709	2427.2	231.95	58.0	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
838	2422	2422.0	53.88	53.9	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
839	2421	2421.0	80.39	80.4	Working memory.	A Baddeley	Science	1992	1736359	No
840	4837	2418.5	157.5	78.8	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
841	4837	2418.5	142.58	71.3	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
842	4833	2416.5	115.31	57.7	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
843	2413	2413.0	52.62	52.6	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
844	2411	2411.0	50.36	50.4	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
845	4821	2410.5	92.8	46.4	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
846	2408	2408.0	43.83	43.8	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
847	4815	2407.5	163.86	81.9	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
848	2406	2406.0	75.67	75.7	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
849	4805	2402.5	143.14	71.6	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
850	2399	2399.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
851	4796	2398.0	93.97	47.0	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
852	2396	2396.0	63.95	64.0	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
853	4777	2388.5	128.72	64.4	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	G Kresse, J Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
854	2388	2388.0	72.48	72.5	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
855	2388	2388.0	93.26	93.3	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
856	2388	2388.0	43.31	43.3	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
857	2386	2386.0	54.51	54.5	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
858	4772	2386.0	133.98	67.0	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
859	4770	2385.0	120.29	60.1	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
860	2382	2382.0	97.97	98.0	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
861	4764	2382.0	207.0	103.5	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
862	2378	2378.0	0.0	0.0	Muscle structure and theories of contraction.	A F Huxley	Prog Biophys Biophys Chem	1957	13485191	Yes
863	2373	2373.0	51.47	51.5	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
864	2370	2370.0	49.28	49.3	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
865	2369	2369.0	62.25	62.2	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
866	7106	2368.7	154.16	51.4	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
867	2365	2365.0	79.41	79.4	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
868	2362	2362.0	97.79	97.8	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
869	2359	2359.0	56.58	56.6	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
870	2357	2357.0	152.64	152.6	Obesity: global epidemiology and pathogenesis.	Matthias Blüher	Nat Rev Endocrinol	2019	30814686	No
871	2356	2356.0	51.61	51.6	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
872	4711	2355.5	97.44	48.7	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
873	4703	2351.5	103.17	51.6	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
874	7049	2349.7	69.93	23.3	On The Nature Of Allosteric Transitions: A Plausible Model.	J Monod, J Wyman, J P Changeux	J Mol Biol	1965	14343300	Yes
875	2348	2348.0	66.64	66.6	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
876	4695	2347.5	118.81	59.4	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
877	4695	2347.5	127.56	63.8	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
878	2347	2347.0	60.38	60.4	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
879	2346	2346.0	111.73	111.7	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
880	4691	2345.5	117.74	58.9	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
881	2344	2344.0	103.73	103.7	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
882	2344	2344.0	57.0	57.0	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
883	4681	2340.5	103.18	51.6	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
884	2338	2338.0	59.07	59.1	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
885	4675	2337.5	171.4	85.7	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
886	2337	2337.0	52.01	52.0	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
887	2337	2337.0	59.47	59.5	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
888	4672	2336.0	102.98	51.5	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
889	4669	2334.5	341.39	170.7	The biology, function, and biomedical applications of exosomes.	Raghu Kalluri, Valerie S LeBleu	Science	2020	32029601	No
890	4662	2331.0	87.78	43.9	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
891	4657	2328.5	122.62	61.3	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
892	2327	2327.0	77.71	77.7	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
893	2325	2325.0	84.24	84.2	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
894	2324	2324.0	66.15	66.2	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
895	2324	2324.0	57.13	57.1	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
896	2323	2323.0	41.96	42.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
897	2322	2322.0	55.43	55.4	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
898	2321	2321.0	57.39	57.4	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
899	4642	2321.0	113.4	56.7	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
900	2320	2320.0	78.35	78.3	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
901	4640	2320.0	124.01	62.0	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
902	2320	2320.0	65.32	65.3	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
903	4638	2319.0	129.89	64.9	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
904	2319	2319.0	50.01	50.0	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
905	4638	2319.0	89.75	44.9	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
906	2318	2318.0	75.5	75.5	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
907	2318	2318.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G Bertani	J Bacteriol	1951	14888646	Yes
908	2317	2317.0	48.82	48.8	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
909	2317	2317.0	135.49	135.5	Toward understanding the origin and evolution of cellular organisms.	Minoru Kanehisa	Protein Sci	2019	31441146	No
910	2313	2313.0	79.42	79.4	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
911	9246	2311.5	201.52	50.4	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
912	2309	2309.0	53.46	53.5	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
913	2309	2309.0	55.82	55.8	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
914	2309	2309.0	27.38	27.4	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T Higuchi	J Pharm Sci	1963	14088963	Yes
915	4615	2307.5	76.18	38.1	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
916	2306	2306.0	58.9	58.9	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
917	2305	2305.0	65.48	65.5	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
918	4602	2301.0	72.03	36.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
919	4600	2300.0	168.76	84.4	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
920	4599	2299.5	123.62	61.8	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
921	2298	2298.0	56.98	57.0	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
922	2298	2298.0	71.78	71.8	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
923	4586	2293.0	86.58	43.3	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
924	4584	2292.0	115.23	57.6	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
925	4580	2290.0	107.01	53.5	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
926	2289	2289.0	60.19	60.2	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
927	2288	2288.0	95.03	95.0	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
928	2287	2287.0	72.73	72.7	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
929	2286	2286.0	105.17	105.2	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
930	2282	2282.0	74.48	74.5	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
931	2282	2282.0	55.71	55.7	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
932	2281	2281.0	71.19	71.2	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
933	2281	2281.0	45.28	45.3	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
934	2278	2278.0	42.72	42.7	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
935	2277	2277.0	60.02	60.0	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
936	2276	2276.0	76.25	76.2	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
937	4551	2275.5	94.81	47.4	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
938	2275	2275.0	59.72	59.7	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
939	13645	2274.2	724.57	120.8	DADA2: High-resolution sample inference from Illumina amplicon data.	Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes	Nat Methods	2016	27214047	Yes
940	2272	2272.0	65.76	65.8	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
941	4543	2271.5	129.53	64.8	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
942	4541	2270.5	101.37	50.7	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
943	2264	2264.0	65.77	65.8	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
944	4528	2264.0	552.22	276.1	Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2021	33885785	Yes
945	2263	2263.0	48.85	48.9	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
946	2263	2263.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A Clauss	Acta Haematol	1957	13434757	Yes
947	2262	2262.0	67.36	67.4	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
948	2260	2260.0	50.97	51.0	Application of a microtechnique to viral serological investigations.	J L Sever	J Immunol	1962	13910995	Yes
949	2260	2260.0	58.5	58.5	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
950	2259	2259.0	44.34	44.3	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
951	4518	2259.0	115.83	57.9	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
952	2258	2258.0	116.43	116.4	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
953	2254	2254.0	68.7	68.7	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
954	2251	2251.0	136.43	136.4	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
955	2251	2251.0	56.03	56.0	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
956	4495	2247.5	102.86	51.4	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
957	8988	2247.0	181.78	45.4	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
958	2246	2246.0	83.93	83.9	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
959	2245	2245.0	53.13	53.1	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
960	2244	2244.0	70.54	70.5	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
961	2243	2243.0	61.33	61.3	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
962	4485	2242.5	108.26	54.1	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
963	4480	2240.0	114.05	57.0	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
964	2240	2240.0	57.24	57.2	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
965	4474	2237.0	88.63	44.3	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
966	2237	2237.0	54.85	54.9	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
967	2236	2236.0	41.73	41.7	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
968	4471	2235.5	88.06	44.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
969	2235	2235.0	110.13	110.1	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
970	4470	2235.0	39.27	19.6	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
971	17863	2232.9	561.68	70.2	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
972	2232	2232.0	77.21	77.2	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
973	4463	2231.5	128.87	64.4	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
974	2231	2231.0	60.14	60.1	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
975	2224	2224.0	48.99	49.0	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
976	2224	2224.0	68.5	68.5	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
977	4447	2223.5	98.24	49.1	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
978	19998	2222.0	915.49	101.7	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
979	2221	2221.0	52.48	52.5	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
980	6658	2219.3	257.41	85.8	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
981	6652	2217.3	183.77	61.3	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
982	2213	2213.0	89.61	89.6	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
983	2212	2212.0	49.29	49.3	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
984	2211	2211.0	87.44	87.4	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
985	2210	2210.0	71.94	71.9	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
986	2209	2209.0	65.49	65.5	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
987	2208	2208.0	61.97	62.0	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
988	4415	2207.5	99.0	49.5	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
989	8830	2207.5	189.01	47.3	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
990	2205	2205.0	83.72	83.7	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
991	2205	2205.0	63.22	63.2	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
992	2204	2204.0	61.47	61.5	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
993	2200	2200.0	54.63	54.6	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
994	2200	2200.0	87.88	87.9	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
995	2199	2199.0	56.8	56.8	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
996	2197	2197.0	46.87	46.9	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
997	4393	2196.5	95.62	47.8	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
998	2196	2196.0	68.08	68.1	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
999	6587	2195.7	194.87	65.0	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
1000	4388	2194.0	148.5	74.2	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1001	2193	2193.0	48.62	48.6	Chemokines.	B J Rollins	Blood	1997	9242519	No
1002	2193	2193.0	70.49	70.5	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
1003	2192	2192.0	79.07	79.1	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
1004	2191	2191.0	53.83	53.8	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1005	4380	2190.0	105.32	52.7	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
1006	4378	2189.0	76.37	38.2	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
1007	2189	2189.0	56.05	56.0	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
1008	6562	2187.3	204.83	68.3	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1009	2186	2186.0	52.71	52.7	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
1010	2184	2184.0	66.37	66.4	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
1011	2183	2183.0	79.23	79.2	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
1012	4365	2182.5	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B Scoville, B Milner	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
1013	2181	2181.0	90.68	90.7	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
1014	2181	2181.0	58.85	58.9	The episodic buffer: a new component of working memory?	A Baddeley	Trends Cogn Sci	2000	11058819	Yes
1015	8718	2179.5	209.24	52.3	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
1016	8716	2179.0	549.04	137.3	Rayyan-a web and mobile app for systematic reviews.	Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid	Syst Rev	2016	27919275	Yes
1017	4357	2178.5	103.46	51.7	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
1018	2176	2176.0	65.94	65.9	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1019	2175	2175.0	48.38	48.4	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1020	2172	2172.0	56.56	56.6	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
1021	2166	2166.0	60.18	60.2	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
1022	2166	2166.0	55.07	55.1	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
1023	34653	2165.8	1111.71	69.5	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
1024	4325	2162.5	147.76	73.9	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
1025	6486	2162.0	197.27	65.8	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1026	4317	2158.5	182.15	91.1	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1027	2158	2158.0	71.04	71.0	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
1028	2158	2158.0	41.74	41.7	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
1029	2154	2154.0	93.17	93.2	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1030	2152	2152.0	49.15	49.1	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1031	2152	2152.0	31.2	31.2	Sedimentation Studies Of The Size And Shape Of Dna.	F W Studier	J Mol Biol	1965	14290352	Yes
1032	6454	2151.3	186.31	62.1	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
1033	2151	2151.0	45.8	45.8	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
1034	4302	2151.0	111.57	55.8	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1035	12905	2150.8	287.93	48.0	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
1036	2150	2150.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H Pennes	J Appl Physiol	1948	18887578	Yes
1037	4300	2150.0	150.14	75.1	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
1038	2149	2149.0	49.59	49.6	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
1039	2149	2149.0	39.98	40.0	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
1040	2148	2148.0	51.57	51.6	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
1041	2145	2145.0	48.71	48.7	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
1042	6434	2144.7	131.58	43.9	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1043	4288	2144.0	117.09	58.5	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1044	2143	2143.0	115.66	115.7	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1045	6425	2141.7	281.26	93.8	Fast and sensitive protein alignment using DIAMOND.	Benjamin Buchfink, Chao Xie, Daniel H Huson	Nat Methods	2015	25402007	Yes
1046	4282	2141.0	100.46	50.2	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
1047	4281	2140.5	83.41	41.7	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1048	2140	2140.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z Dische	J Biol Chem	1947	20281638	Yes
1049	4278	2139.0	73.25	36.6	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H Venable, R Coggeshall	J Cell Biol	1965	14287192	Yes
1050	4275	2137.5	103.49	51.7	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1051	4274	2137.0	106.96	53.5	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
1052	4273	2136.5	80.43	40.2	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
1053	6404	2134.7	131.25	43.8	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
1054	2134	2134.0	64.71	64.7	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
1055	6400	2133.3	149.87	50.0	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1056	2131	2131.0	49.47	49.5	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1057	2129	2129.0	59.04	59.0	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1058	6386	2128.7	146.26	48.8	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
1059	4256	2128.0	122.51	61.3	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
1060	4256	2128.0	127.75	63.9	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1061	6381	2127.0	161.39	53.8	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1062	2127	2127.0	42.12	42.1	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
1063	4253	2126.5	135.03	67.5	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
1064	4240	2120.0	82.66	41.3	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
1065	6357	2119.0	270.65	90.2	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
1066	2117	2117.0	63.98	64.0	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
1067	4228	2114.0	121.42	60.7	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
1068	2113	2113.0	35.26	35.3	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D Aminoff	Biochem J	1961	13860975	Yes
1069	2112	2112.0	50.93	50.9	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1070	6332	2110.7	117.72	39.2	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
1071	4220	2110.0	178.94	89.5	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1072	2110	2110.0	44.44	44.4	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
1073	4215	2107.5	106.83	53.4	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
1074	2105	2105.0	74.77	74.8	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
1075	2104	2104.0	38.08	38.1	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
1076	2104	2104.0	47.51	47.5	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1077	6310	2103.3	267.48	89.2	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
1078	2102	2102.0	60.63	60.6	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
1079	2100	2100.0	52.4	52.4	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1080	2098	2098.0	42.47	42.5	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
1081	2096	2096.0	49.36	49.4	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
1082	2096	2096.0	83.6	83.6	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
1083	2093	2093.0	94.11	94.1	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
1084	4182	2091.0	120.64	60.3	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
1085	8353	2088.2	397.87	99.5	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1086	2088	2088.0	42.53	42.5	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
1087	2087	2087.0	45.36	45.4	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1088	8347	2086.8	303.62	75.9	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1089	6258	2086.0	185.86	62.0	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
1090	4167	2083.5	109.07	54.5	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1091	4164	2082.0	100.63	50.3	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1092	4162	2081.0	185.79	92.9	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1093	2081	2081.0	39.38	39.4	Method For Assay Of Intestinal Disaccharidases.	A Dahlqvist	Anal Biochem	1964	14106916	Yes
1094	2080	2080.0	53.03	53.0	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
1095	10399	2079.8	241.2	48.2	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1096	2078	2078.0	71.82	71.8	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1097	4155	2077.5	78.46	39.2	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1098	4153	2076.5	109.83	54.9	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1099	4152	2076.0	81.81	40.9	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
1100	4152	2076.0	82.05	41.0	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
1101	8293	2073.2	272.19	68.0	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1102	2072	2072.0	59.86	59.9	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1103	2072	2072.0	50.76	50.8	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1104	4143	2071.5	80.79	40.4	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1105	4143	2071.5	35.75	17.9	Genetic regulatory mechanisms in the synthesis of proteins.	F Jacob, J Monod	J Mol Biol	1961	13718526	Yes
1106	2071	2071.0	50.53	50.5	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1107	4142	2071.0	118.26	59.1	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1108	2065	2065.0	37.83	37.8	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C Skou	Physiol Rev	1965	14337569	No
1109	4129	2064.5	129.54	64.8	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1110	2064	2064.0	52.81	52.8	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
1111	2064	2064.0	41.39	41.4	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1112	2064	2064.0	129.74	129.7	High-performance medicine: the convergence of human and artificial intelligence.	Eric J Topol	Nat Med	2019	30617339	No
1113	2061	2061.0	39.7	39.7	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1114	4121	2060.5	85.95	43.0	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1115	2058	2058.0	42.59	42.6	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1116	4113	2056.5	105.05	52.5	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1117	6169	2056.3	202.15	67.4	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1118	4112	2056.0	122.65	61.3	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
1119	2055	2055.0	52.28	52.3	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1120	4109	2054.5	101.25	50.6	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1121	4107	2053.5	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R Dulbecco, M Vogt	J Exp Med	1954	13130792	Yes
1122	4105	2052.5	177.44	88.7	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1123	2052	2052.0	18.77	18.8	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W Cleland	Biochim Biophys Acta	1963	14021667	Yes
1124	2052	2052.0	60.61	60.6	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1125	2051	2051.0	24.81	24.8	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W Littlefield	Science	1964	14168277	Yes
1126	2051	2051.0	47.81	47.8	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1127	6150	2050.0	198.09	66.0	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1128	2049	2049.0	64.92	64.9	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1129	2048	2048.0	47.84	47.8	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1130	4087	2043.5	110.53	55.3	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1131	2043	2043.0	41.8	41.8	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1132	4083	2041.5	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F Beers, I W Sizer	J Biol Chem	1952	14938361	Yes
1133	2041	2041.0	56.48	56.5	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
1134	2037	2037.0	61.14	61.1	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1135	2037	2037.0	120.53	120.5	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
1136	2035	2035.0	63.62	63.6	Receiver operating characteristic curve in diagnostic test assessment.	Jayawant N Mandrekar	J Thorac Oncol	2010	20736804	No
1137	4063	2031.5	97.6	48.8	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1138	4060	2030.0	98.24	49.1	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1139	2030	2030.0	39.12	39.1	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
1140	8112	2028.0	304.9	76.2	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1141	2028	2028.0	47.6	47.6	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
1142	2027	2027.0	79.71	79.7	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1143	2027	2027.0	72.09	72.1	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
1144	4052	2026.0	94.69	47.3	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
1145	4050	2025.0	79.48	39.7	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1146	2024	2024.0	62.12	62.1	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
1147	12144	2024.0	375.12	62.5	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
1148	6066	2022.0	182.91	61.0	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
1149	2021	2021.0	52.51	52.5	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
1150	2021	2021.0	0.0	0.0	On respiratory impairment in cancer cells.	O Warburg	Science	1956	13351639	Yes
1151	2021	2021.0	55.31	55.3	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1152	4042	2021.0	136.19	68.1	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
1153	6061	2020.3	228.14	76.0	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1154	2019	2019.0	42.48	42.5	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1155	2017	2017.0	44.15	44.1	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1156	2017	2017.0	44.17	44.2	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
1157	2016	2016.0	46.86	46.9	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1158	6045	2015.0	162.63	54.2	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón	Bioinformatics	2009	19505945	Yes
1159	2013	2013.0	38.76	38.8	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1160	2012	2012.0	58.33	58.3	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1161	2011	2011.0	83.73	83.7	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1162	2011	2011.0	95.97	96.0	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1163	4021	2010.5	119.45	59.7	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1164	2010	2010.0	22.26	22.3	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V Neel	Am J Hum Genet	1962	13937884	Yes
1165	2010	2010.0	0.0	0.0	Antigen-antibody reactions in gels.	O Ouchterlony	Acta Pathol Microbiol Scand	1949	18143039	Yes
1166	2009	2009.0	51.11	51.1	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1167	2009	2009.0	68.42	68.4	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1168	2008	2008.0	41.63	41.6	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
1169	8030	2007.5	194.63	48.7	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1170	2005	2005.0	48.3	48.3	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1171	2005	2005.0	34.61	34.6	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
1172	8018	2004.5	327.59	81.9	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1173	2002	2002.0	36.67	36.7	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
1174	2002	2002.0	50.17	50.2	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1175	4004	2002.0	88.24	44.1	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1176	8003	2000.8	236.19	59.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1177	4001	2000.5	117.65	58.8	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1178	2000	2000.0	39.53	39.5	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1179	2000	2000.0	54.96	55.0	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1180	21993	1999.4	546.45	49.7	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1181	1999	1999.0	43.8	43.8	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1182	1999	1999.0	55.95	56.0	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1183	13993	1999.0	307.49	43.9	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1184	1997	1997.0	43.51	43.5	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1185	1994	1994.0	101.4	101.4	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1186	3987	1993.5	91.26	45.6	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1187	3986	1993.0	90.24	45.1	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1188	1992	1992.0	41.47	41.5	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1189	1991	1991.0	38.7	38.7	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1190	1991	1991.0	42.49	42.5	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1191	3982	1991.0	87.77	43.9	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1192	3980	1990.0	89.82	44.9	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1193	1989	1989.0	54.77	54.8	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1194	3978	1989.0	85.44	42.7	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1195	1988	1988.0	47.72	47.7	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1196	1987	1987.0	39.16	39.2	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1197	1987	1987.0	70.24	70.2	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1198	1987	1987.0	116.6	116.6	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
1199	3972	1986.0	86.24	43.1	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
1200	1985	1985.0	40.71	40.7	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
1201	3970	1985.0	141.79	70.9	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1202	1985	1985.0	48.54	48.5	Negative refraction makes a perfect lens	J B Pendry	Phys Rev Lett	2000	11041972	Yes
1203	3970	1985.0	137.52	68.8	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1204	13889	1984.1	316.27	45.2	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1205	1984	1984.0	65.91	65.9	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1206	1982	1982.0	63.04	63.0	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1207	3960	1980.0	110.67	55.3	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1208	1980	1980.0	61.53	61.5	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1209	3951	1975.5	98.04	49.0	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1210	1975	1975.0	48.21	48.2	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1211	3947	1973.5	108.35	54.2	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1212	1973	1973.0	49.3	49.3	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1213	1970	1970.0	62.5	62.5	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1214	1970	1970.0	52.6	52.6	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1215	5908	1969.3	191.99	64.0	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1216	1967	1967.0	86.83	86.8	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1217	1966	1966.0	61.63	61.6	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1218	1965	1965.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
1219	1964	1964.0	34.79	34.8	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1220	3921	1960.5	96.37	48.2	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1221	1960	1960.0	57.71	57.7	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1222	3919	1959.5	125.53	62.8	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
1223	1959	1959.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A Sholl	J Anat	1953	13117757	Yes
1224	1958	1958.0	41.07	41.1	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1225	1958	1958.0	34.11	34.1	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1226	1958	1958.0	60.09	60.1	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1227	1957	1957.0	45.81	45.8	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1228	1957	1957.0	37.32	37.3	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1229	1956	1956.0	45.08	45.1	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1230	1955	1955.0	62.41	62.4	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1231	3909	1954.5	132.22	66.1	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1232	1953	1953.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R Steele	Ann N Y Acad Sci	1959	13833973	Yes
1233	3906	1953.0	60.09	30.0	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R Morrison, L M Smith	J Lipid Res	1964	14221106	Yes
1234	3898	1949.0	95.31	47.7	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1235	1949	1949.0	61.18	61.2	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1236	5846	1948.7	106.92	35.6	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1237	1947	1947.0	39.36	39.4	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1238	1946	1946.0	79.1	79.1	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1239	3892	1946.0	65.22	32.6	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1240	1946	1946.0	0.0	0.0	On estimating the relation between blood group and disease.	B Woolf	Ann Hum Genet	1955	14388528	Yes
1241	1945	1945.0	37.53	37.5	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1242	1945	1945.0	38.92	38.9	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1243	1944	1944.0	39.78	39.8	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1244	5829	1943.0	120.0	40.0	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1245	1943	1943.0	40.44	40.4	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1246	1940	1940.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V Boyden	J Exp Med	1951	14803635	Yes
1247	1939	1939.0	41.15	41.1	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1248	3877	1938.5	90.59	45.3	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1249	3875	1937.5	121.73	60.9	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1250	1937	1937.0	64.43	64.4	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1251	1937	1937.0	49.98	50.0	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1252	5804	1934.7	168.81	56.3	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1253	1934	1934.0	60.54	60.5	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1254	3868	1934.0	122.79	61.4	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1255	7733	1933.2	186.73	46.7	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1256	1932	1932.0	55.21	55.2	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1257	1932	1932.0	57.61	57.6	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1258	1932	1932.0	42.22	42.2	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1259	1931	1931.0	23.2	23.2	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1260	1929	1929.0	46.73	46.7	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1261	1928	1928.0	50.65	50.6	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1262	1927	1927.0	42.7	42.7	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1263	5779	1926.3	190.6	63.5	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1264	3851	1925.5	94.39	47.2	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1265	3850	1925.0	102.67	51.3	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1266	1925	1925.0	43.06	43.1	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1267	3850	1925.0	122.15	61.1	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1268	1924	1924.0	44.45	44.5	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1269	1923	1923.0	41.68	41.7	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1270	3846	1923.0	73.53	36.8	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1271	1922	1922.0	83.64	83.6	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1272	3844	1922.0	130.5	65.2	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1273	1922	1922.0	45.5	45.5	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1274	1922	1922.0	58.43	58.4	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
1275	3836	1918.0	98.74	49.4	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	S Nie, S R Emory	Science	1997	9027306	Yes
1276	1918	1918.0	56.38	56.4	Inhibited spontaneous emission in solid-state physics and electronics.	E Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1277	1917	1917.0	63.13	63.1	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1278	1917	1917.0	33.81	33.8	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1279	1917	1917.0	39.09	39.1	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1280	3833	1916.5	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J Vogel, D M Bonner	J Biol Chem	1956	13278318	Yes
1281	1916	1916.0	59.8	59.8	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1282	1915	1915.0	40.06	40.1	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1283	1915	1915.0	46.98	47.0	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1284	1915	1915.0	46.21	46.2	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1285	1914	1914.0	53.22	53.2	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1286	7654	1913.5	297.99	74.5	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1287	1913	1913.0	43.12	43.1	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1288	7650	1912.5	188.43	47.1	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1289	3825	1912.5	84.84	42.4	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1290	1912	1912.0	54.76	54.8	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1291	1912	1912.0	44.83	44.8	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1292	7646	1911.5	185.87	46.5	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1293	1909	1909.0	46.19	46.2	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1294	3814	1907.0	115.11	57.6	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1295	1907	1907.0	51.46	51.5	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1296	3813	1906.5	129.9	65.0	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1297	5718	1906.0	197.89	66.0	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1298	1904	1904.0	53.77	53.8	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1299	1904	1904.0	63.06	63.1	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1300	3806	1903.0	136.89	68.4	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1301	3804	1902.0	153.39	76.7	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
1302	5704	1901.3	145.07	48.4	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1303	3802	1901.0	334.25	167.1	WHO Declares COVID-19 a Pandemic.	Domenico Cucinotta, Maurizio Vanelli	Acta Biomed	2020	32191675	Yes
1304	1900	1900.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H Hirs	J Biol Chem	1956	13319283	Yes
1305	1900	1900.0	40.49	40.5	The etiology of chondromalacia patellae.	R E Outerbridge	J Bone Joint Surg Br	1961	14038135	Yes
1306	1899	1899.0	74.09	74.1	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1307	15191	1898.9	630.15	78.8	The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.	Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner	Nucleic Acids Res	2013	23193283	Yes
1308	1898	1898.0	53.29	53.3	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1309	1897	1897.0	65.33	65.3	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1310	1896	1896.0	53.4	53.4	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1311	1896	1896.0	69.54	69.5	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
1312	3791	1895.5	137.82	68.9	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1313	5684	1894.7	341.56	113.9	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1314	3787	1893.5	156.64	78.3	Cancer immunotherapy using checkpoint blockade.	Antoni Ribas, Jedd D Wolchok	Science	2018	29567705	No
1315	1893	1893.0	41.08	41.1	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1316	1893	1893.0	50.07	50.1	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1317	5675	1891.7	431.97	144.0	An interactive web-based dashboard to track COVID-19 in real time.	Ensheng Dong, Hongru Du, Lauren Gardner	Lancet Infect Dis	2020	32087114	Yes
1318	3783	1891.5	118.12	59.1	Efficient pseudopotentials for plane-wave calculations.	N Troullier, J L Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1319	3780	1890.0	84.81	42.4	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1320	15118	1889.8	368.78	46.1	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1321	3779	1889.5	107.34	53.7	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1322	1888	1888.0	45.48	45.5	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1323	1887	1887.0	60.19	60.2	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1324	1887	1887.0	69.14	69.1	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1325	3772	1886.0	104.24	52.1	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1326	3772	1886.0	68.42	34.2	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1327	1885	1885.0	79.09	79.1	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1328	3768	1884.0	112.61	56.3	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1329	7533	1883.2	252.83	63.2	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1330	1883	1883.0	16.0	16.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1331	1882	1882.0	68.91	68.9	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1332	1882	1882.0	48.22	48.2	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1333	3762	1881.0	89.62	44.8	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1334	1880	1880.0	41.12	41.1	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1335	3759	1879.5	86.14	43.1	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1336	9381	1876.2	221.52	44.3	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1337	1875	1875.0	53.57	53.6	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1338	1874	1874.0	49.08	49.1	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1339	3746	1873.0	86.07	43.0	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1340	1873	1873.0	60.26	60.3	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1341	1871	1871.0	86.74	86.7	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1342	3742	1871.0	77.51	38.8	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1343	1870	1870.0	0.0	0.0	Cognitive maps in rats and men.	E C Tolman	Psychol Rev	1948	18870876	Yes
1344	1870	1870.0	44.49	44.5	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1345	3739	1869.5	78.45	39.2	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1346	1869	1869.0	39.94	39.9	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1347	3737	1868.5	125.52	62.8	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1348	5602	1867.3	775.71	258.6	MEGA11: Molecular Evolutionary Genetics Analysis Version 11.	Koichiro Tamura, Glen Stecher, Sudhir Kumar	Mol Biol Evol	2021	33892491	Yes
1349	1867	1867.0	50.79	50.8	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1350	13062	1866.0	465.02	66.4	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1351	1865	1865.0	43.95	44.0	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1352	3730	1865.0	142.87	71.4	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
1353	1864	1864.0	37.4	37.4	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1354	5592	1864.0	125.24	41.7	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1355	1864	1864.0	41.88	41.9	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1356	3720	1860.0	78.61	39.3	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1357	1860	1860.0	54.35	54.4	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
1358	1860	1860.0	114.6	114.6	The Global Epidemic of the Metabolic Syndrome.	Mohammad G Saklayen	Curr Hypertens Rep	2018	29480368	No
1359	1859	1859.0	48.7	48.7	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1360	3717	1858.5	82.52	41.3	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1361	1858	1858.0	52.09	52.1	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1362	1857	1857.0	41.19	41.2	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1363	1856	1856.0	41.68	41.7	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1364	1855	1855.0	56.11	56.1	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1365	1855	1855.0	50.49	50.5	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1366	5562	1854.0	234.21	78.1	The behaviour change wheel: a new method for characterising and designing behaviour change interventions.	Susan Michie, Maartje M van Stralen, Robert West	Implement Sci	2011	21513547	No
1367	7415	1853.8	205.65	51.4	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1368	1853	1853.0	45.3	45.3	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1369	1851	1851.0	85.07	85.1	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1370	3702	1851.0	76.72	38.4	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1371	7404	1851.0	178.87	44.7	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1372	3702	1851.0	105.48	52.7	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1373	5552	1850.7	138.75	46.2	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1374	14777	1847.1	415.3	51.9	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1375	1847	1847.0	48.5	48.5	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1376	3690	1845.0	99.8	49.9	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1377	3690	1845.0	52.78	26.4	Immunoassay of insulin with insulin-antibody precipitate.	C N Hales, P J Randle	Biochem J	1963	13952078	Yes
1378	1843	1843.0	52.94	52.9	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1379	3685	1842.5	128.66	64.3	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1380	5525	1841.7	121.96	40.7	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1381	1841	1841.0	45.02	45.0	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1382	3678	1839.0	120.22	60.1	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1383	3678	1839.0	110.48	55.2	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1384	1838	1838.0	41.4	41.4	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1385	3674	1837.0	76.3	38.1	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1386	7346	1836.5	339.75	84.9	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1387	1836	1836.0	76.85	76.8	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
1388	3671	1835.5	246.52	123.3	Interactive Tree Of Life (iTOL) v4: recent updates and new developments.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2019	30931475	Yes
1389	1835	1835.0	68.1	68.1	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1390	1835	1835.0	35.32	35.3	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1391	1834	1834.0	53.84	53.8	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1392	1833	1833.0	44.53	44.5	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1393	1833	1833.0	41.1	41.1	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1394	1833	1833.0	17.75	17.8	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A Robinson	IEEE Trans Biomed Eng	1963	14121113	Yes
1395	1833	1833.0	36.33	36.3	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1396	5497	1832.3	121.18	40.4	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1397	3664	1832.0	87.9	44.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1398	1831	1831.0	56.43	56.4	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1399	10980	1830.0	320.59	53.4	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1400	1829	1829.0	36.57	36.6	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1401	3653	1826.5	111.5	55.8	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1402	1824	1824.0	50.02	50.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1403	1823	1823.0	65.96	66.0	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1404	3646	1823.0	124.76	62.4	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1405	1821	1821.0	49.59	49.6	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1406	1821	1821.0	51.19	51.2	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1407	1821	1821.0	45.48	45.5	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1408	1820	1820.0	70.0	70.0	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1409	1816	1816.0	48.44	48.4	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1410	3631	1815.5	86.97	43.5	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1411	5443	1814.3	102.79	34.3	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1412	3627	1813.5	92.46	46.2	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1413	1813	1813.0	53.8	53.8	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1414	1813	1813.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C Skou	Biochim Biophys Acta	1957	13412736	Yes
1415	1813	1813.0	39.79	39.8	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1416	1811	1811.0	55.07	55.1	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1417	5429	1809.7	166.16	55.4	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1418	3619	1809.5	87.3	43.6	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1419	1809	1809.0	19.8	19.8	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S Cohen	J Biol Chem	1962	13880319	Yes
1420	5426	1808.7	113.03	37.7	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	J H Zhang, T D Chung, K R Oldenburg	J Biomol Screen	1999	10838414	Yes
1421	1808	1808.0	59.07	59.1	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1422	3614	1807.0	101.98	51.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1423	1807	1807.0	49.07	49.1	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1424	3613	1806.5	93.0	46.5	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1425	9025	1805.0	235.48	47.1	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1426	1804	1804.0	65.95	66.0	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1427	3605	1802.5	116.46	58.2	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1428	1802	1802.0	35.47	35.5	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1429	1802	1802.0	42.5	42.5	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1430	1801	1801.0	56.42	56.4	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1431	1800	1800.0	42.55	42.5	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1432	1800	1800.0	36.33	36.3	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1433	1800	1800.0	136.29	136.3	User's guide to correlation coefficients.	Haldun Akoglu	Turk J Emerg Med	2018	30191186	No
1434	5398	1799.3	142.58	47.5	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1435	7197	1799.2	273.53	68.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
1436	1799	1799.0	39.01	39.0	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1437	3593	1796.5	126.62	63.3	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1438	1796	1796.0	48.08	48.1	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1439	1796	1796.0	44.03	44.0	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1440	1794	1794.0	0.0	0.0	The measurement of volume changes in human limbs.	R J Whitney	J Physiol	1953	13085295	Yes
1441	3588	1794.0	158.31	79.2	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
1442	10762	1793.7	321.24	53.5	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1443	1793	1793.0	43.03	43.0	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1444	3584	1792.0	83.31	41.7	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1445	1791	1791.0	62.48	62.5	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1446	1790	1790.0	98.05	98.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1447	1790	1790.0	71.82	71.8	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1448	3579	1789.5	160.78	80.4	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1449	3578	1789.0	85.83	42.9	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1450	1789	1789.0	18.61	18.6	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1451	1789	1789.0	36.54	36.5	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1452	1789	1789.0	36.4	36.4	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1453	1789	1789.0	49.5	49.5	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1454	3577	1788.5	71.16	35.6	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
1455	1788	1788.0	54.44	54.4	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1456	3575	1787.5	180.69	90.3	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1457	3575	1787.5	99.26	49.6	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1458	1787	1787.0	58.49	58.5	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1459	3574	1787.0	70.59	35.3	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
1460	5351	1783.7	140.92	47.0	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1461	8918	1783.6	296.55	59.3	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
1462	3566	1783.0	142.43	71.2	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1463	3566	1783.0	128.74	64.4	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
1464	1782	1782.0	59.3	59.3	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1465	7128	1782.0	138.5	34.6	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1466	1782	1782.0	32.69	32.7	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1467	12458	1779.7	300.17	42.9	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1468	1779	1779.0	36.76	36.8	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1469	3557	1778.5	134.65	67.3	The Emerging Hallmarks of Cancer Metabolism.	Natalya N Pavlova, Craig B Thompson	Cell Metab	2016	26771115	No
1470	3555	1777.5	88.05	44.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1471	12438	1776.9	415.59	59.4	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
1472	1776	1776.0	36.26	36.3	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1473	1776	1776.0	59.12	59.1	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1474	1775	1775.0	35.99	36.0	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1475	7100	1775.0	233.66	58.4	Common method biases in behavioral research: a critical review of the literature and recommended remedies.	Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff	J Appl Psychol	2003	14516251	No
1476	1774	1774.0	71.23	71.2	Macrophage Polarization.	Peter J Murray	Annu Rev Physiol	2017	27813830	No
1477	1773	1773.0	60.93	60.9	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1478	3546	1773.0	79.84	39.9	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1479	3545	1772.5	109.65	54.8	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1480	1770	1770.0	72.91	72.9	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1481	1770	1770.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S Hestrin	J Biol Chem	1949	18133390	Yes
1482	3539	1769.5	88.42	44.2	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1483	3539	1769.5	73.56	36.8	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1484	1769	1769.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D Simpson	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1485	1768	1768.0	42.16	42.2	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1486	1768	1768.0	58.66	58.7	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1487	7068	1767.0	297.7	74.4	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1488	1767	1767.0	55.59	55.6	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1489	1766	1766.0	57.41	57.4	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1490	3532	1766.0	90.3	45.1	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1491	1765	1765.0	43.94	43.9	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1492	1763	1763.0	66.09	66.1	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1493	1763	1763.0	53.13	53.1	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1494	1763	1763.0	46.46	46.5	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1495	17625	1762.5	552.12	55.2	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1496	3525	1762.5	74.68	37.3	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1497	1762	1762.0	49.11	49.1	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1498	1762	1762.0	39.02	39.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1499	1762	1762.0	42.25	42.2	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1500	1761	1761.0	46.13	46.1	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1501	1760	1760.0	47.5	47.5	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1502	1760	1760.0	57.06	57.1	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1503	3519	1759.5	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T Campbell, D W Fiske	Psychol Bull	1959	13634291	Yes
1504	3519	1759.5	88.46	44.2	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
1505	1759	1759.0	40.62	40.6	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1506	1759	1759.0	46.6	46.6	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1507	3518	1759.0	45.62	22.8	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1508	1758	1758.0	66.47	66.5	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
1509	3514	1757.0	86.55	43.3	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1510	1756	1756.0	42.53	42.5	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1511	3512	1756.0	95.97	48.0	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1512	1755	1755.0	41.61	41.6	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1513	1754	1754.0	40.1	40.1	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1514	3508	1754.0	82.61	41.3	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1515	3508	1754.0	104.26	52.1	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1516	1751	1751.0	61.09	61.1	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1517	3501	1750.5	92.89	46.4	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1518	1750	1750.0	32.97	33.0	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1519	5245	1748.3	117.95	39.3	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1520	1748	1748.0	38.58	38.6	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1521	1748	1748.0	0.0	0.0	A personality scale of manifest anxiety.	J A Taylor	J Abnorm Psychol	1953	13052352	Yes
1522	3495	1747.5	163.79	81.9	Making sense of Cronbach's alpha.	Mohsen Tavakol, Reg Dennick	Int J Med Educ	2011	28029643	No
1523	5242	1747.3	135.25	45.1	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1524	1747	1747.0	44.45	44.5	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1525	3491	1745.5	92.44	46.2	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1526	1745	1745.0	37.87	37.9	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1527	1745	1745.0	42.19	42.2	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1528	1745	1745.0	33.61	33.6	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1529	3489	1744.5	150.59	75.3	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1530	3489	1744.5	70.33	35.2	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
1531	1744	1744.0	46.85	46.9	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1532	3486	1743.0	179.54	89.8	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1533	1743	1743.0	40.67	40.7	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1534	1743	1743.0	69.54	69.5	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1535	3485	1742.5	135.92	68.0	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1536	13940	1742.5	401.98	50.2	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
1537	1741	1741.0	65.21	65.2	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1538	6962	1740.5	135.86	34.0	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1539	3481	1740.5	72.98	36.5	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1540	3480	1740.0	98.19	49.1	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1541	8698	1739.6	197.62	39.5	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1542	1737	1737.0	73.89	73.9	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1543	1735	1735.0	56.68	56.7	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1544	3470	1735.0	138.87	69.4	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
1545	1734	1734.0	38.84	38.8	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1546	1734	1734.0	61.86	61.9	Modeling Development and Disease with Organoids.	Hans Clevers	Cell	2016	27315476	No
1547	8667	1733.4	325.69	65.1	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1548	1733	1733.0	62.56	62.6	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1549	1733	1733.0	54.17	54.2	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1550	1733	1733.0	50.02	50.0	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1551	1733	1733.0	37.31	37.3	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1552	1732	1732.0	39.47	39.5	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1553	3464	1732.0	74.36	37.2	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1554	5196	1732.0	186.28	62.1	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
1555	5194	1731.3	135.65	45.2	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1556	8653	1730.6	213.32	42.7	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1557	5189	1729.7	112.34	37.4	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1558	5188	1729.3	155.43	51.8	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
1559	3458	1729.0	93.92	47.0	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1560	1729	1729.0	59.35	59.4	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1561	3457	1728.5	90.65	45.3	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1562	1728	1728.0	41.09	41.1	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1563	1728	1728.0	37.39	37.4	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1564	1728	1728.0	45.75	45.8	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1565	1727	1727.0	56.27	56.3	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1566	1726	1726.0	61.26	61.3	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1567	1726	1726.0	79.2	79.2	Neutrophil extracellular traps in immunity and disease.	Venizelos Papayannopoulos	Nat Rev Immunol	2018	28990587	No
1568	3449	1724.5	131.52	65.8	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1569	1724	1724.0	56.42	56.4	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1570	1724	1724.0	70.85	70.8	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1571	1724	1724.0	40.6	40.6	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1572	1723	1723.0	37.6	37.6	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1573	1721	1721.0	31.02	31.0	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1574	1721	1721.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1575	1721	1721.0	46.91	46.9	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
1576	3442	1721.0	113.12	56.6	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
1577	5162	1720.7	231.14	77.0	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1578	1720	1720.0	56.5	56.5	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1579	6878	1719.5	197.46	49.4	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1580	1718	1718.0	56.65	56.6	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1581	5153	1717.7	168.37	56.1	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1582	3435	1717.5	103.86	51.9	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
1583	3434	1717.0	125.93	63.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1584	3434	1717.0	70.13	35.1	'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?	George Davey Smith, Shah Ebrahim	Int J Epidemiol	2003	12689998	No
1585	3434	1717.0	96.29	48.1	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1586	3433	1716.5	86.57	43.3	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1587	5145	1715.0	161.39	53.8	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1588	5140	1713.3	113.02	37.7	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1589	1713	1713.0	38.53	38.5	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1590	1713	1713.0	59.52	59.5	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1591	1713	1713.0	44.54	44.5	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1592	1713	1713.0	51.42	51.4	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1593	1712	1712.0	64.8	64.8	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1594	1712	1712.0	41.92	41.9	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1595	1712	1712.0	32.79	32.8	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1596	1712	1712.0	45.46	45.5	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1597	3422	1711.0	110.2	55.1	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1598	1711	1711.0	31.38	31.4	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1599	1711	1711.0	33.53	33.5	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1600	1710	1710.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H Selye	J Clin Endocrinol Metab	1946	21025115	Yes
1601	3418	1709.0	222.83	111.4	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1602	3418	1709.0	86.42	43.2	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1603	3417	1708.5	82.44	41.2	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1604	3416	1708.0	146.19	73.1	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1605	1708	1708.0	68.63	68.6	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1606	5124	1708.0	295.01	98.3	SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.	Antoine Daina, Olivier Michielin, Vincent Zoete	Sci Rep	2017	28256516	Yes
1607	17073	1707.3	541.77	54.2	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1608	1707	1707.0	52.43	52.4	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1609	1707	1707.0	38.45	38.5	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1610	1707	1707.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1611	5119	1706.3	119.96	40.0	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1612	1706	1706.0	39.25	39.2	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1613	1706	1706.0	82.37	82.4	Hydrogel: Preparation, characterization, and applications: A review.	Enas M Ahmed	J Adv Res	2015	25750745	No
1614	3411	1705.5	108.18	54.1	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1615	1705	1705.0	34.47	34.5	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1616	6816	1704.0	143.42	35.9	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1617	3408	1704.0	140.41	70.2	Parkinson's disease.	Lorraine V Kalia, Anthony E Lang	Lancet	2015	25904081	No
1618	3407	1703.5	78.27	39.1	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1619	1703	1703.0	31.17	31.2	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1620	1703	1703.0	36.8	36.8	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1621	1702	1702.0	52.19	52.2	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1622	3402	1701.0	50.63	25.3	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J Karnovsky, L Roots	J Histochem Cytochem	1964	14187330	Yes
1623	1701	1701.0	82.15	82.2	International classification of sleep disorders-third edition: highlights and modifications.	Michael J Sateia	Chest	2014	25367475	No
1624	6802	1700.5	196.21	49.1	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1625	3401	1700.5	92.34	46.2	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1626	10200	1700.0	284.5	47.4	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1627	1700	1700.0	39.52	39.5	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1628	3400	1700.0	87.69	43.8	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1629	1699	1699.0	41.37	41.4	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1630	1699	1699.0	53.24	53.2	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1631	1698	1698.0	55.11	55.1	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1632	1697	1697.0	42.87	42.9	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1633	3392	1696.0	81.24	40.6	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1634	1696	1696.0	18.27	18.3	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1635	1695	1695.0	73.12	73.1	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1636	3390	1695.0	70.59	35.3	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1637	1695	1695.0	31.19	31.2	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1638	1695	1695.0	35.99	36.0	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1639	1695	1695.0	58.61	58.6	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
1640	8473	1694.6	91.67	18.3	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe	JAMA	1963	14044222	Yes
1641	3389	1694.5	93.6	46.8	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1642	1694	1694.0	40.08	40.1	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1643	3388	1694.0	92.51	46.3	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1644	6774	1693.5	266.44	66.6	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1645	5080	1693.3	109.31	36.4	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1646	1692	1692.0	38.97	39.0	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1647	1691	1691.0	45.28	45.3	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1648	1691	1691.0	51.59	51.6	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1649	3380	1690.0	125.71	62.9	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1650	1689	1689.0	42.72	42.7	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1651	1688	1688.0	40.24	40.2	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1652	1687	1687.0	29.33	29.3	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H Mollenhauer	Stain Technol	1964	14127791	Yes
1653	3374	1687.0	71.61	35.8	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1654	1687	1687.0	36.65	36.6	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1655	3373	1686.5	98.93	49.5	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1656	1686	1686.0	20.11	20.1	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1657	3372	1686.0	83.63	41.8	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1658	1686	1686.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S Kety	Pharmacol Rev	1951	14833874	Yes
1659	6740	1685.0	205.6	51.4	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1660	1685	1685.0	41.28	41.3	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1661	3369	1684.5	69.81	34.9	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1662	1684	1684.0	39.86	39.9	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1663	18516	1683.3	578.35	52.6	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
1664	3365	1682.5	82.81	41.4	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1665	1681	1681.0	46.56	46.6	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1666	1681	1681.0	50.21	50.2	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1667	1680	1680.0	62.04	62.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1668	1680	1680.0	32.93	32.9	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1669	1680	1680.0	38.62	38.6	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1670	1680	1680.0	42.86	42.9	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1671	1679	1679.0	30.99	31.0	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1672	1679	1679.0	50.88	50.9	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1673	6715	1678.8	222.41	55.6	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1674	5036	1678.7	198.85	66.3	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1675	1678	1678.0	58.39	58.4	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1676	1678	1678.0	39.51	39.5	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1677	1677	1677.0	64.4	64.4	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1678	1677	1677.0	49.22	49.2	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1679	1677	1677.0	30.76	30.8	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1680	3354	1677.0	78.27	39.1	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1681	1677	1677.0	14.05	14.1	Chromatographic Separation Of Human Brain Gangliosides.	L Svennerholm	J Neurochem	1963	14066623	Yes
1682	1677	1677.0	35.99	36.0	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1683	1677	1677.0	47.01	47.0	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1684	1676	1676.0	58.61	58.6	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1685	1676	1676.0	47.07	47.1	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1686	1676	1676.0	46.32	46.3	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
1687	1676	1676.0	50.6	50.6	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
1688	3351	1675.5	79.08	39.5	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1689	10049	1674.8	204.82	34.1	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1690	3348	1674.0	216.8	108.4	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1691	1674	1674.0	45.06	45.1	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1692	1674	1674.0	53.51	53.5	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1693	1673	1673.0	37.23	37.2	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1694	5018	1672.7	264.82	88.3	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1695	1671	1671.0	38.28	38.3	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1696	11695	1670.7	345.3	49.3	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
1697	3341	1670.5	109.93	55.0	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1698	3339	1669.5	53.79	26.9	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J Marmur, P Doty	J Mol Biol	1962	14470099	Yes
1699	3339	1669.5	78.56	39.3	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1700	1669	1669.0	82.2	82.2	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1701	1668	1668.0	68.08	68.1	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1702	1668	1668.0	74.52	74.5	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1703	1668	1668.0	35.69	35.7	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1704	1667	1667.0	31.79	31.8	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1705	1667	1667.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F Boas	J Biol Chem	1953	13117829	Yes
1706	1667	1667.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G Gray	J Anat	1959	13829103	Yes
1707	1665	1665.0	37.69	37.7	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1708	1664	1664.0	52.59	52.6	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1709	1664	1664.0	54.8	54.8	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1710	1664	1664.0	32.23	32.2	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1711	1664	1664.0	46.66	46.7	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1712	1664	1664.0	47.1	47.1	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1713	1663	1663.0	39.74	39.7	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1714	1661	1661.0	59.66	59.7	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1715	3321	1660.5	87.23	43.6	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1716	3320	1660.0	66.79	33.4	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1717	1658	1658.0	45.4	45.4	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1718	3315	1657.5	154.66	77.3	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1719	3314	1657.0	54.63	27.3	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T Omura, R Sato	J Biol Chem	1964	14209972	Yes
1720	1657	1657.0	53.62	53.6	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
1721	3313	1656.5	83.99	42.0	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
1722	3312	1656.0	83.8	41.9	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1723	1656	1656.0	23.8	23.8	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1724	3311	1655.5	73.67	36.8	ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking.	Matthew D Wilkerson, D Neil Hayes	Bioinformatics	2010	20427518	Yes
1725	1655	1655.0	41.84	41.8	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1726	3310	1655.0	66.35	33.2	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1727	3308	1654.0	58.75	29.4	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1728	1654	1654.0	193.28	193.3	COVID-19 and mental health: A review of the existing literature.	Ravi Philip Rajkumar	Asian J Psychiatr	2020	32302935	Yes
1729	6615	1653.8	152.68	38.2	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1730	1653	1653.0	47.09	47.1	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1731	6607	1651.8	287.32	71.8	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1732	1651	1651.0	31.05	31.1	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1733	1651	1651.0	33.16	33.2	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1734	1650	1650.0	57.13	57.1	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1735	3300	1650.0	75.16	37.6	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1736	1649	1649.0	57.91	57.9	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1737	9881	1646.8	227.73	38.0	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1738	3293	1646.5	63.55	31.8	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1739	3292	1646.0	117.63	58.8	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1740	1646	1646.0	66.84	66.8	Structure, Function, and Evolution of Coronavirus Spike Proteins.	Fang Li	Annu Rev Virol	2016	27578435	No
1741	3291	1645.5	71.25	35.6	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1742	1645	1645.0	42.65	42.6	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1743	1645	1645.0	73.17	73.2	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1744	3289	1644.5	68.34	34.2	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1745	4933	1644.3	116.8	38.9	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1746	1644	1644.0	34.75	34.8	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1747	1643	1643.0	53.95	54.0	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1748	1643	1643.0	42.8	42.8	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1749	1642	1642.0	48.57	48.6	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1750	1642	1642.0	45.05	45.0	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1751	4925	1641.7	103.68	34.6	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
1752	1641	1641.0	57.46	57.5	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1753	1641	1641.0	48.67	48.7	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1754	1640	1640.0	49.56	49.6	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
1755	1640	1640.0	40.51	40.5	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
1756	3280	1640.0	101.22	50.6	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
1757	1637	1637.0	37.29	37.3	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1758	3272	1636.0	85.01	42.5	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1759	1635	1635.0	33.25	33.2	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1760	1635	1635.0	49.91	49.9	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1761	1635	1635.0	29.07	29.1	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1762	4903	1634.3	95.23	31.7	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1763	1634	1634.0	40.68	40.7	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1764	3265	1632.5	99.44	49.7	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
1765	1632	1632.0	56.54	56.5	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1766	1631	1631.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A Lassen	Physiol Rev	1959	13645234	Yes
1767	1630	1630.0	40.51	40.5	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D Mattingly	J Clin Pathol	1962	14471419	Yes
1768	1629	1629.0	58.39	58.4	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1769	1629	1629.0	42.46	42.5	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1770	1629	1629.0	34.62	34.6	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1771	11403	1629.0	316.37	45.2	BLAST+: architecture and applications.	Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden	BMC Bioinformatics	2009	20003500	Yes
1772	1628	1628.0	50.98	51.0	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1773	1628	1628.0	70.95	71.0	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1774	1628	1628.0	38.19	38.2	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
1775	1627	1627.0	56.68	56.7	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
1776	1627	1627.0	40.06	40.1	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1777	1626	1626.0	45.14	45.1	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1778	1626	1626.0	52.66	52.7	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1779	1625	1625.0	58.13	58.1	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1780	9747	1624.5	337.87	56.3	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1781	6497	1624.2	220.71	55.2	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
1782	3248	1624.0	89.31	44.7	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1783	4872	1624.0	128.01	42.7	Fast model-based estimation of ancestry in unrelated individuals.	David H Alexander, John Novembre, Kenneth Lange	Genome Res	2009	19648217	Yes
1784	3248	1624.0	103.24	51.6	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
1785	1623	1623.0	22.82	22.8	Structural considerations in the interaction of DNA and acridines.	L S Lerman	J Mol Biol	1961	13761054	Yes
1786	1622	1622.0	52.01	52.0	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1787	1621	1621.0	56.13	56.1	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1788	1621	1621.0	39.56	39.6	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1789	1620	1620.0	46.32	46.3	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1790	3239	1619.5	76.76	38.4	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1791	1619	1619.0	27.54	27.5	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1792	1619	1619.0	47.68	47.7	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
1793	1619	1619.0	37.08	37.1	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1794	19426	1618.8	789.64	65.8	Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.	Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm	Genet Med	2015	25741868	No
1795	3237	1618.5	96.37	48.2	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1796	1618	1618.0	47.64	47.6	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1797	6471	1617.8	2523.02	630.8	Cancer statistics, 2023.	Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle, Ahmedin Jemal	CA Cancer J Clin	2023	36633525	Yes
1798	1617	1617.0	30.2	30.2	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1799	1617	1617.0	36.14	36.1	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
1800	3233	1616.5	98.09	49.0	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
1801	1616	1616.0	42.75	42.8	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1802	1615	1615.0	30.38	30.4	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1803	1614	1614.0	45.6	45.6	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1804	1614	1614.0	39.38	39.4	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1805	1614	1614.0	44.6	44.6	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1806	1614	1614.0	45.03	45.0	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1807	1614	1614.0	63.65	63.6	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
1808	1613	1613.0	33.95	34.0	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1809	1613	1613.0	31.0	31.0	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1810	3226	1613.0	77.01	38.5	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
1811	1613	1613.0	75.0	75.0	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
1812	3224	1612.0	71.4	35.7	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1813	1612	1612.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1814	1611	1611.0	37.47	37.5	Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults.	Bei-Fan Zhou	Biomed Environ Sci	2002	12046553	Yes
1815	1610	1610.0	80.76	80.8	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1816	1609	1609.0	31.65	31.6	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1817	3216	1608.0	124.74	62.4	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
1818	3214	1607.0	62.59	31.3	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1819	3214	1607.0	66.32	33.2	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1820	3213	1606.5	62.1	31.1	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
1821	3212	1606.0	100.24	50.1	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1822	3210	1605.0	83.47	41.7	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1823	3209	1604.5	169.02	84.5	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
1824	1603	1603.0	36.9	36.9	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1825	1602	1602.0	36.86	36.9	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
1826	3204	1602.0	113.45	56.7	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1827	1602	1602.0	39.04	39.0	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1828	1602	1602.0	35.86	35.9	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1829	1602	1602.0	36.42	36.4	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1830	3203	1601.5	94.96	47.5	Unified approach for molecular dynamics and density-functional theory.	R Car, M Parrinello	Phys Rev Lett	1985	10032153	Yes
1831	3203	1601.5	62.66	31.3	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1832	3203	1601.5	93.1	46.5	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1833	3203	1601.5	131.82	65.9	Sex differences in immune responses.	Sabra L Klein, Katie L Flanagan	Nat Rev Immunol	2016	27546235	No
1834	1601	1601.0	42.36	42.4	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1835	3202	1601.0	61.78	30.9	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1836	4801	1600.3	172.34	57.4	Complex heatmaps reveal patterns and correlations in multidimensional genomic data.	Zuguang Gu, Roland Eils, Matthias Schlesner	Bioinformatics	2016	27207943	Yes
1837	1600	1600.0	40.86	40.9	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1838	1600	1600.0	50.87	50.9	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1839	1600	1600.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O Ouchterlony	Acta Pathol Microbiol Scand	1953	13079779	Yes
1840	1599	1599.0	34.43	34.4	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1841	1599	1599.0	36.2	36.2	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
1842	1598	1598.0	49.04	49.0	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1843	1598	1598.0	45.84	45.8	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1844	9588	1598.0	225.33	37.6	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
1845	3195	1597.5	89.33	44.7	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1846	1597	1597.0	31.5	31.5	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1847	1597	1597.0	30.61	30.6	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
1848	1597	1597.0	72.44	72.4	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1849	3193	1596.5	117.39	58.7	Elements of cancer immunity and the cancer-immune set point.	Daniel S Chen, Ira Mellman	Nature	2017	28102259	No
1850	1596	1596.0	57.19	57.2	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1851	1596	1596.0	71.1	71.1	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1852	3192	1596.0	67.34	33.7	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1853	1595	1595.0	28.82	28.8	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1854	3190	1595.0	87.86	43.9	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1855	1595	1595.0	36.84	36.8	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1856	1595	1595.0	40.51	40.5	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
1857	3189	1594.5	139.82	69.9	MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.	Rajesha Rupaimoole, Frank J Slack	Nat Rev Drug Discov	2017	28209991	No
1858	4783	1594.3	237.43	79.1	Radiomics: Images Are More than Pictures, They Are Data.	Robert J Gillies, Paul E Kinahan, Hedvig Hricak	Radiology	2016	26579733	Yes
1859	1594	1594.0	34.32	34.3	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1860	1594	1594.0	30.53	30.5	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1861	9562	1593.7	269.3	44.9	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
1862	3187	1593.5	77.52	38.8	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1863	3187	1593.5	93.96	47.0	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
1864	1593	1593.0	39.26	39.3	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
1865	1593	1593.0	30.92	30.9	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1866	1593	1593.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J Rankin	Scott Med J	1957	13432835	Yes
1867	3186	1593.0	65.19	32.6	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1868	4777	1592.3	130.66	43.6	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1869	4776	1592.0	116.15	38.7	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1870	3183	1591.5	69.09	34.5	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1871	1591	1591.0	38.26	38.3	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
1872	4770	1590.0	115.59	38.5	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1873	1590	1590.0	34.47	34.5	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1874	1590	1590.0	60.02	60.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
1875	9538	1589.7	279.84	46.6	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke	Lancet	2007	18064739	Yes
1876	3179	1589.5	75.3	37.6	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1877	1589	1589.0	47.76	47.8	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1878	1589	1589.0	35.79	35.8	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1879	1589	1589.0	51.93	51.9	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1880	1588	1588.0	110.61	110.6	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
1881	3175	1587.5	91.17	45.6	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1882	3174	1587.0	118.27	59.1	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
1883	1587	1587.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W Kuffler	J Neurophysiol	1953	13035466	Yes
1884	3174	1587.0	91.69	45.8	Extended-connectivity fingerprints.	David Rogers, Mathew Hahn	J Chem Inf Model	2010	20426451	Yes
1885	3172	1586.0	70.44	35.2	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1886	1586	1586.0	29.84	29.8	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1887	3172	1586.0	98.81	49.4	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1888	1584	1584.0	49.5	49.5	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1889	1583	1583.0	51.65	51.6	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1890	1583	1583.0	20.26	20.3	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W Cleland	Biochemistry	1964	14192894	Yes
1891	4748	1582.7	122.45	40.8	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1892	1582	1582.0	37.34	37.3	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1893	6327	1581.8	154.59	38.6	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1894	3163	1581.5	96.94	48.5	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
1895	1581	1581.0	62.28	62.3	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
1896	3161	1580.5	152.0	76.0	A simple practice guide for dose conversion between animals and human.	Anroop B Nair, Shery Jacob	J Basic Clin Pharm	2016	27057123	No
1897	1580	1580.0	29.78	29.8	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1898	3160	1580.0	109.25	54.6	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
1899	3159	1579.5	207.73	103.9	ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R.	Emmanuel Paradis, Klaus Schliep	Bioinformatics	2019	30016406	Yes
1900	1578	1578.0	29.27	29.3	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1901	4732	1577.3	105.68	35.2	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M G Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1902	1577	1577.0	42.72	42.7	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1903	1577	1577.0	33.51	33.5	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1904	3154	1577.0	68.04	34.0	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1905	1577	1577.0	35.95	36.0	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1906	3153	1576.5	82.09	41.0	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
1907	1576	1576.0	35.29	35.3	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1908	3152	1576.0	57.71	28.9	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1909	3152	1576.0	67.32	33.7	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1910	1575	1575.0	52.67	52.7	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
1911	3150	1575.0	185.35	92.7	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1912	1575	1575.0	37.59	37.6	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1913	1575	1575.0	48.69	48.7	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
1914	1575	1575.0	33.43	33.4	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1915	3150	1575.0	95.42	47.7	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
1916	4722	1574.0	182.2	60.7	Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.	Jack Bowden, George Davey Smith, Stephen Burgess	Int J Epidemiol	2015	26050253	Yes
1917	1573	1573.0	64.66	64.7	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
1918	1573	1573.0	26.01	26.0	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1919	1573	1573.0	29.55	29.6	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1920	3146	1573.0	88.91	44.5	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
1921	1572	1572.0	41.65	41.6	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1922	3143	1571.5	101.1	50.5	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
1923	3143	1571.5	74.05	37.0	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1924	3142	1571.0	66.99	33.5	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
1925	1571	1571.0	31.19	31.2	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1926	3142	1571.0	66.76	33.4	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1927	1570	1570.0	44.87	44.9	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
1928	14125	1569.4	434.85	48.3	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
1929	4707	1569.0	93.11	31.0	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1930	1569	1569.0	27.79	27.8	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1931	3138	1569.0	75.93	38.0	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1932	3138	1569.0	60.46	30.2	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1933	1569	1569.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C Hummel	Can J Biochem Physiol	1959	14405350	Yes
1934	3137	1568.5	78.97	39.5	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1935	1568	1568.0	33.62	33.6	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
1936	1568	1568.0	60.23	60.2	AliView: a fast and lightweight alignment viewer and editor for large datasets.	Anders Larsson	Bioinformatics	2014	25095880	Yes
1937	1567	1567.0	59.23	59.2	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1938	3134	1567.0	95.13	47.6	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
1939	4700	1566.7	87.59	29.2	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1940	3130	1565.0	107.51	53.8	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
1941	17214	1564.9	449.0	40.8	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
1942	1564	1564.0	42.15	42.1	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
1943	3126	1563.0	80.73	40.4	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
1944	1562	1562.0	61.33	61.3	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1945	1561	1561.0	36.37	36.4	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1946	1560	1560.0	31.29	31.3	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1947	1560	1560.0	42.92	42.9	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
1948	1560	1560.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
1949	1560	1560.0	58.79	58.8	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
1950	3118	1559.0	66.43	33.2	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1951	15587	1558.7	370.91	37.1	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1952	1558	1558.0	45.49	45.5	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
1953	1558	1558.0	38.29	38.3	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1954	3115	1557.5	121.35	60.7	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1955	1557	1557.0	77.93	77.9	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
1956	1557	1557.0	48.38	48.4	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1957	3114	1557.0	58.49	29.2	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1958	1557	1557.0	43.78	43.8	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1959	3114	1557.0	69.0	34.5	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
1960	1556	1556.0	36.22	36.2	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
1961	1556	1556.0	65.42	65.4	Periodontitis: from microbial immune subversion to systemic inflammation.	George Hajishengallis	Nat Rev Immunol	2015	25534621	No
1962	1555	1555.0	35.05	35.0	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1963	1555	1555.0	28.62	28.6	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1964	3108	1554.0	93.27	46.6	CTFFIND4: Fast and accurate defocus estimation from electron micrographs.	Alexis Rohou, Nikolaus Grigorieff	J Struct Biol	2015	26278980	Yes
1965	4661	1553.7	103.54	34.5	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
1966	3107	1553.5	75.61	37.8	Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.	Felix Krueger, Simon R Andrews	Bioinformatics	2011	21493656	Yes
1967	4657	1552.3	155.86	52.0	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1968	1552	1552.0	48.84	48.8	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1969	3103	1551.5	71.69	35.8	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1970	3099	1549.5	61.72	30.9	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1971	1549	1549.0	42.14	42.1	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1972	1549	1549.0	36.9	36.9	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1973	3096	1548.0	79.55	39.8	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1974	3096	1548.0	56.52	28.3	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1975	1548	1548.0	51.57	51.6	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
1976	7739	1547.8	152.49	30.5	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1977	4643	1547.7	88.5	29.5	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
1978	1547	1547.0	43.76	43.8	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
1979	3094	1547.0	39.95	20.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1980	1547	1547.0	32.21	32.2	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1981	3094	1547.0	104.17	52.1	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
1982	1546	1546.0	67.37	67.4	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
1983	1546	1546.0	51.26	51.3	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1984	3092	1546.0	76.84	38.4	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1985	3090	1545.0	184.72	92.4	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1986	1545	1545.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H Eagle	Science	1955	13255879	Yes
1987	1545	1545.0	60.9	60.9	The global burden of IBD: from 2015 to 2025.	Gilaad G Kaplan	Nat Rev Gastroenterol Hepatol	2015	26323879	No
1988	4634	1544.7	130.69	43.6	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1989	3089	1544.5	61.92	31.0	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1990	4633	1544.3	127.33	42.4	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1991	3088	1544.0	63.48	31.7	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1992	1544	1544.0	45.28	45.3	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
1993	1542	1542.0	29.98	30.0	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1994	1542	1542.0	43.55	43.5	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1995	1542	1542.0	42.82	42.8	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
1996	1542	1542.0	59.79	59.8	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
1997	4625	1541.7	119.16	39.7	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
1998	1540	1540.0	53.17	53.2	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
1999	1540	1540.0	43.71	43.7	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2000	1539	1539.0	30.77	30.8	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
2001	1539	1539.0	32.93	32.9	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
2002	3077	1538.5	21.55	10.8	Junctional complexes in various epithelia.	M G Farquhar, G E Palade	J Cell Biol	1963	13944428	Yes
2003	4613	1537.7	111.95	37.3	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2004	3075	1537.5	73.43	36.7	Decision curve analysis: a novel method for evaluating prediction models.	Andrew J Vickers, Elena B Elkin	Med Decis Making	2006	17099194	Yes
2005	1537	1537.0	49.14	49.1	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
2006	3074	1537.0	71.39	35.7	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
2007	4611	1537.0	117.62	39.2	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
2008	6148	1537.0	119.25	29.8	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
2009	3074	1537.0	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G Schmidt, S J Thannhauser	J Biol Chem	1945	21005717	Yes
2010	3072	1536.0	62.42	31.2	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
2011	1536	1536.0	41.73	41.7	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
2012	1535	1535.0	65.86	65.9	Machine Learning in Medicine.	Rahul C Deo	Circulation	2015	26572668	No
2013	3069	1534.5	80.49	40.2	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
2014	1534	1534.0	30.13	30.1	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
2015	4602	1534.0	99.09	33.0	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
2016	9202	1533.7	282.45	47.1	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
2017	3067	1533.5	87.87	43.9	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
2018	3066	1533.0	66.48	33.2	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
2019	1532	1532.0	45.78	45.8	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
2020	3064	1532.0	79.01	39.5	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
2021	1531	1531.0	56.48	56.5	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
2022	1531	1531.0	37.91	37.9	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
2023	3062	1531.0	67.17	33.6	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
2024	9183	1530.5	215.16	35.9	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2025	3061	1530.5	197.33	98.7	OrthoFinder: phylogenetic orthology inference for comparative genomics.	David M Emms, Steven Kelly	Genome Biol	2019	31727128	Yes
2026	1530	1530.0	67.06	67.1	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2027	3059	1529.5	88.94	44.5	Software survey: VOSviewer, a computer program for bibliometric mapping.	Nees Jan van Eck, Ludo Waltman	Scientometrics	2010	20585380	Yes
2028	1529	1529.0	47.45	47.5	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2029	1529	1529.0	33.77	33.8	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
2030	4585	1528.3	51.84	17.3	Improved method for the determination of blood glutathione.	E Beutler, O Duron, B M Kelly	J Lab Clin Med	1963	13967893	Yes
2031	1528	1528.0	33.72	33.7	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
2032	1528	1528.0	41.26	41.3	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
2033	1528	1528.0	22.23	22.2	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
2034	1528	1528.0	46.03	46.0	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
2035	1528	1528.0	34.57	34.6	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
2036	1528	1528.0	31.37	31.4	Antigen-Antibody Crossed Electrophoresis.	C B Laurell	Anal Biochem	1965	14302464	Yes
2037	1526	1526.0	34.65	34.6	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
2038	3052	1526.0	67.48	33.7	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
2039	1525	1525.0	42.36	42.4	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
2040	3049	1524.5	70.88	35.4	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
2041	1524	1524.0	38.78	38.8	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
2042	1523	1523.0	18.69	18.7	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
2043	1523	1523.0	50.23	50.2	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
2044	1522	1522.0	51.53	51.5	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2045	4564	1521.3	158.06	52.7	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
2046	1521	1521.0	45.3	45.3	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
2047	1521	1521.0	90.84	90.8	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
2048	1521	1521.0	49.84	49.8	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2049	3042	1521.0	88.36	44.2	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2050	3041	1520.5	114.32	57.2	Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.	Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon	Brain Connect	2012	22642651	Yes
2051	1520	1520.0	56.03	56.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
2052	1520	1520.0	48.64	48.6	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2053	3039	1519.5	82.94	41.5	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2054	4557	1519.0	96.13	32.0	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
2055	1518	1518.0	38.18	38.2	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
2056	1518	1518.0	49.26	49.3	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2057	1517	1517.0	31.66	31.7	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
2058	1515	1515.0	37.98	38.0	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
2059	1515	1515.0	27.92	27.9	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
2060	1515	1515.0	42.65	42.6	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
2061	1515	1515.0	32.95	33.0	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
2062	1514	1514.0	39.94	39.9	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
2063	1514	1514.0	50.23	50.2	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
2064	4542	1514.0	120.57	40.2	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2065	4541	1513.7	222.28	74.1	Shedding light on the cell biology of extracellular vesicles.	Guillaume van Niel, Gisela D'Angelo, Graça Raposo	Nat Rev Mol Cell Biol	2018	29339798	No
2066	1513	1513.0	44.08	44.1	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2067	1513	1513.0	48.48	48.5	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2068	1513	1513.0	48.24	48.2	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
2069	1510	1510.0	33.55	33.5	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
2070	1509	1509.0	37.13	37.1	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
2071	3016	1508.0	76.67	38.3	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
2072	3016	1508.0	62.04	31.0	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2073	1506	1506.0	0.0	0.0	A new readability yardstick.	R Flesch	J Appl Psychol	1948	18867058	Yes
2074	3011	1505.5	58.95	29.5	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
2075	19558	1504.5	506.11	38.9	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2076	3009	1504.5	115.34	57.7	Cisplatin in cancer therapy: molecular mechanisms of action.	Shaloam Dasari, Paul Bernard Tchounwou	Eur J Pharmacol	2014	25058905	No
2077	1504	1504.0	32.95	33.0	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2078	3007	1503.5	101.64	50.8	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
2079	4509	1503.0	162.38	54.1	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
2080	1503	1503.0	31.63	31.6	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2081	3005	1502.5	87.84	43.9	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
2082	1502	1502.0	43.87	43.9	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2083	1501	1501.0	40.8	40.8	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
2084	1501	1501.0	36.51	36.5	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2085	3001	1500.5	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
2086	1500	1500.0	59.39	59.4	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2087	3000	1500.0	60.09	30.0	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
2088	1500	1500.0	32.58	32.6	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2089	1500	1500.0	25.41	25.4	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K Fuxe	Acta Physiol Scand Suppl	1965	14319769	Yes
2090	3000	1500.0	88.59	44.3	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
2091	2999	1499.5	66.36	33.2	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
2092	1499	1499.0	26.4	26.4	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
2093	1499	1499.0	42.47	42.5	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
2094	1498	1498.0	52.16	52.2	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
2095	1498	1498.0	35.58	35.6	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
2096	1497	1497.0	55.17	55.2	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2097	1497	1497.0	33.6	33.6	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
2098	1497	1497.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
2099	1496	1496.0	47.95	48.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
2100	2992	1496.0	64.2	32.1	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2101	2992	1496.0	0.0	0.0	Lactic dehydrogenase activity in blood.	F Wroblewski, J S Ladue	Proc Soc Exp Biol Med	1955	13273400	Yes
2102	10468	1495.4	222.68	31.8	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
2103	1495	1495.0	60.3	60.3	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
2104	1494	1494.0	70.82	70.8	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
2105	1493	1493.0	77.01	77.0	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2106	1493	1493.0	26.13	26.1	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
2107	1493	1493.0	36.97	37.0	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
2108	1492	1492.0	33.07	33.1	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
2109	1492	1492.0	46.53	46.5	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
2110	4476	1492.0	129.49	43.2	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallières, C M. Morin	Sleep Med	2001	11438246	Yes
2111	4475	1491.7	111.69	37.2	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2112	5965	1491.2	130.04	32.5	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
2113	13416	1490.7	621.98	69.1	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2114	2980	1490.0	56.92	28.5	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
2115	1489	1489.0	43.13	43.1	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
2116	2974	1487.0	74.74	37.4	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2117	1486	1486.0	34.19	34.2	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
2118	1486	1486.0	39.12	39.1	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
2119	1486	1486.0	36.84	36.8	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2120	2970	1485.0	87.4	43.7	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2121	1485	1485.0	31.65	31.6	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2122	4453	1484.3	93.59	31.2	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
2123	2968	1484.0	89.01	44.5	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
2124	1483	1483.0	33.24	33.2	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
2125	1482	1482.0	27.35	27.4	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
2126	1482	1482.0	7.91	7.9	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W Sperry	Proc Natl Acad Sci U S A	1963	14077501	Yes
2127	2964	1482.0	98.91	49.5	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2128	1481	1481.0	18.45	18.4	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
2129	2961	1480.5	106.79	53.4	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2130	4441	1480.3	45.76	15.3	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T Dodge, C Mitchell, D J Hanahan	Arch Biochem Biophys	1963	14028302	Yes
2131	1480	1480.0	36.51	36.5	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
2132	1480	1480.0	19.72	19.7	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
2133	1480	1480.0	40.27	40.3	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
2134	4440	1480.0	79.05	26.3	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A Winter, E A Risley, G W Nuss	Proc Soc Exp Biol Med	1962	14001233	Yes
2135	1480	1480.0	33.86	33.9	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
2136	8878	1479.7	258.74	43.1	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
2137	4438	1479.3	134.96	45.0	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2138	1479	1479.0	36.79	36.8	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2139	1479	1479.0	39.49	39.5	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
2140	1478	1478.0	45.69	45.7	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
2141	1478	1478.0	30.69	30.7	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
2142	1478	1478.0	45.84	45.8	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
2143	5910	1477.5	246.7	61.7	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
2144	1477	1477.0	43.13	43.1	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2145	1476	1476.0	33.77	33.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2146	1476	1476.0	45.25	45.2	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2147	2951	1475.5	120.1	60.0	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
2148	4426	1475.3	86.36	28.8	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2149	1475	1475.0	36.23	36.2	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
2150	1475	1475.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
2151	1474	1474.0	94.96	95.0	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2152	1474	1474.0	12.89	12.9	The Relation Of Recombination To Mutational Advance.	H J Muller	Mutat Res	1964	14195748	Yes
2153	1474	1474.0	38.32	38.3	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2154	1474	1474.0	52.47	52.5	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
2155	1473	1473.0	19.62	19.6	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2156	2946	1473.0	74.3	37.1	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2157	1473	1473.0	10.68	10.7	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E Huxley	J Mol Biol	1963	14064165	Yes
2158	2945	1472.5	76.44	38.2	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
2159	1472	1472.0	34.19	34.2	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C Nowell	Cancer Res	1960	14427849	Yes
2160	2943	1471.5	78.0	39.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
2161	2942	1471.0	91.85	45.9	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
2162	1471	1471.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B Mountcastle	J Neurophysiol	1957	13439410	Yes
2163	13235	1470.6	407.38	45.3	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
2164	7351	1470.2	326.58	65.3	BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.	Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov	Bioinformatics	2015	26059717	Yes
2165	1470	1470.0	60.42	60.4	Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.	Karimollah Hajian-Tilaki	Caspian J Intern Med	2013	24009950	No
2166	1469	1469.0	40.13	40.1	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
2167	5873	1468.2	213.72	53.4	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
2168	1468	1468.0	57.31	57.3	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2169	1468	1468.0	37.2	37.2	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2170	2935	1467.5	41.1	20.6	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G Gray, V P Whittaker	J Anat	1962	13901297	Yes
2171	4402	1467.3	95.53	31.8	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
2172	4401	1467.0	137.25	45.8	AChE-stained horizontal sections of the rat brain in stereotaxic coordinates.	G Paxinos, C R Watson, P C Emson	J Neurosci Methods	1980	6110810	Yes
2173	1467	1467.0	35.0	35.0	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2174	1466	1466.0	41.09	41.1	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2175	1466	1466.0	41.74	41.7	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2176	2931	1465.5	77.83	38.9	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
2177	2930	1465.0	94.48	47.2	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
2178	1465	1465.0	33.51	33.5	Simple methods for "staining with lead" at high pH in electron microscopy.	M J Karnovsky	J Biophys Biochem Cytol	1961	14454024	Yes
2179	1464	1464.0	31.81	31.8	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2180	1464	1464.0	31.7	31.7	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2181	2927	1463.5	67.71	33.9	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2182	1463	1463.0	33.82	33.8	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
2183	1463	1463.0	38.16	38.2	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2184	1462	1462.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P Moran	Biometrika	1950	15420245	Yes
2185	2922	1461.0	98.49	49.2	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
2186	2922	1461.0	57.9	28.9	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2187	1461	1461.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
2188	2922	1461.0	73.55	36.8	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
2189	1461	1461.0	40.86	40.9	BEDTools: The Swiss-Army Tool for Genome Feature Analysis.	Aaron R Quinlan	Curr Protoc Bioinformatics	2014	25199790	Yes
2190	1460	1460.0	51.41	51.4	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2191	1460	1460.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E Bush	Biochem J	1952	14915960	Yes
2192	1460	1460.0	64.65	64.7	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
2193	1459	1459.0	34.15	34.1	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
2194	1458	1458.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H Rosen	Arch Biochem Biophys	1957	13412116	Yes
2195	1457	1457.0	34.33	34.3	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
2196	1457	1457.0	29.74	29.7	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
2197	1457	1457.0	35.61	35.6	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2198	1457	1457.0	43.81	43.8	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2199	1457	1457.0	32.89	32.9	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2200	1457	1457.0	64.52	64.5	Oxidative stress: a concept in redox biology and medicine.	Helmut Sies	Redox Biol	2015	25588755	No
2201	5824	1456.0	147.62	36.9	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2202	1456	1456.0	40.76	40.8	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2203	2911	1455.5	75.06	37.5	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
2204	2911	1455.5	60.33	30.2	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2205	11643	1455.4	289.32	36.2	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2206	1455	1455.0	39.04	39.0	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
2207	2909	1454.5	87.42	43.7	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2208	2908	1454.0	99.53	49.8	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
2209	1454	1454.0	57.61	57.6	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2210	1454	1454.0	47.72	47.7	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
2211	1454	1454.0	31.56	31.6	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
2212	4360	1453.3	100.78	33.6	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2213	5812	1453.0	158.22	39.6	Image quality assessment: from error visibility to structural similarity.	Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli	IEEE Trans Image Process	2004	15376593	Yes
2214	2905	1452.5	102.73	51.4	Role of the microbiota in immunity and inflammation.	Yasmine Belkaid, Timothy W Hand	Cell	2014	24679531	No
2215	2904	1452.0	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H Clarke, J Casals	Am J Trop Med Hyg	1958	13571577	Yes
2216	2904	1452.0	73.8	36.9	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2217	1450	1450.0	28.84	28.8	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
2218	2900	1450.0	79.53	39.8	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
2219	2900	1450.0	57.57	28.8	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2220	1450	1450.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L Welch	Biometrika	1947	20287819	Yes
2221	2899	1449.5	72.4	36.2	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
2222	4348	1449.3	92.65	30.9	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
2223	1449	1449.0	33.61	33.6	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
2224	1449	1449.0	94.72	94.7	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
2225	1449	1449.0	40.0	40.0	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2226	1448	1448.0	48.58	48.6	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
2227	5790	1447.5	162.25	40.6	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
2228	1447	1447.0	35.49	35.5	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2229	2894	1447.0	94.64	47.3	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
2230	1447	1447.0	36.97	37.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2231	2894	1447.0	66.02	33.0	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
2232	1447	1447.0	36.18	36.2	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
2233	2894	1447.0	62.17	31.1	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H Anton, D F Sayre	J Pharmacol Exp Ther	1962	14013351	Yes
2234	1446	1446.0	49.89	49.9	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
2235	1446	1446.0	30.3	30.3	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
2236	1445	1445.0	42.99	43.0	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2237	2890	1445.0	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
2238	2886	1443.0	78.41	39.2	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2239	1443	1443.0	37.8	37.8	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2240	2885	1442.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D Davis, E S Mingioli	J Bacteriol	1950	15436457	Yes
2241	2883	1441.5	67.41	33.7	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
2242	1441	1441.0	42.15	42.1	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
2243	1441	1441.0	21.54	21.5	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2244	2882	1441.0	85.8	42.9	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2245	1441	1441.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
2246	5762	1440.5	168.58	42.1	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2247	1440	1440.0	48.25	48.2	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2248	2880	1440.0	55.33	27.7	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2249	4318	1439.3	87.02	29.0	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2250	1439	1439.0	37.16	37.2	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
2251	1439	1439.0	43.78	43.8	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2252	1439	1439.0	42.67	42.7	Strong localization of photons in certain disordered dielectric superlattices.	S John	Phys Rev Lett	1987	10034761	Yes
2253	4316	1438.7	147.06	49.0	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2254	2877	1438.5	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J Bloom, W W Richardson	Br J Cancer	1957	13499785	Yes
2255	1438	1438.0	37.52	37.5	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2256	1438	1438.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D Poulik	Nature	1957	13493570	Yes
2257	2874	1437.0	53.65	26.8	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2258	1437	1437.0	33.86	33.9	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2259	1437	1437.0	50.02	50.0	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2260	1436	1436.0	36.59	36.6	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2261	1436	1436.0	27.43	27.4	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2262	1436	1436.0	53.84	53.8	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2263	8609	1434.8	282.35	47.1	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
2264	1434	1434.0	40.04	40.0	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2265	1433	1433.0	65.21	65.2	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
2266	7160	1432.0	154.21	30.8	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
2267	1432	1432.0	40.81	40.8	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2268	2862	1431.0	96.06	48.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2269	1431	1431.0	60.37	60.4	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2270	1431	1431.0	35.91	35.9	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2271	4289	1429.7	87.64	29.2	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
2272	2859	1429.5	70.29	35.1	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
2273	2858	1429.0	98.11	49.1	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2274	1429	1429.0	24.75	24.8	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2275	1429	1429.0	39.47	39.5	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2276	2854	1427.0	83.0	41.5	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
2277	1427	1427.0	44.52	44.5	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2278	1426	1426.0	43.04	43.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2279	1426	1426.0	34.77	34.8	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2280	4277	1425.7	121.59	40.5	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2281	2851	1425.5	86.09	43.0	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2282	5702	1425.5	256.46	64.1	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2283	2850	1425.0	82.18	41.1	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2284	2849	1424.5	90.39	45.2	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2285	1424	1424.0	25.56	25.6	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2286	2848	1424.0	54.89	27.4	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2287	4271	1423.7	107.46	35.8	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2288	2846	1423.0	54.92	27.5	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2289	1423	1423.0	44.13	44.1	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2290	1422	1422.0	40.88	40.9	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2291	1422	1422.0	27.38	27.4	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L Ramanathan	J Appl Physiol	1964	14173555	Yes
2292	1421	1421.0	33.26	33.3	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
2293	1421	1421.0	33.69	33.7	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2294	2841	1420.5	72.87	36.4	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
2295	4260	1420.0	101.16	33.7	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2296	8519	1419.8	217.85	36.3	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2297	4259	1419.7	94.22	31.4	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2298	1419	1419.0	51.18	51.2	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
2299	2838	1419.0	148.24	74.1	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2300	1419	1419.0	26.54	26.5	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
2301	1419	1419.0	37.64	37.6	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2302	1419	1419.0	36.6	36.6	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2303	2836	1418.0	79.34	39.7	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2304	1418	1418.0	17.12	17.1	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J Wyman	Adv Protein Chem	1964	14268785	No
2305	2835	1417.5	83.44	41.7	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2306	2835	1417.5	62.4	31.2	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2307	1417	1417.0	45.01	45.0	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2308	2833	1416.5	89.75	44.9	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2309	2831	1415.5	88.71	44.4	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
2310	4246	1415.3	139.76	46.6	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2311	1415	1415.0	35.0	35.0	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2312	1415	1415.0	57.41	57.4	Transcriptional architecture of the mammalian circadian clock.	Joseph S Takahashi	Nat Rev Genet	2017	27990019	No
2313	2826	1413.0	52.31	26.2	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2314	4235	1411.7	148.07	49.4	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2315	1411	1411.0	45.91	45.9	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
2316	1411	1411.0	33.95	34.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2317	1411	1411.0	35.59	35.6	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2318	4232	1410.7	154.39	51.5	Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.	C J Caspersen, K E Powell, G M Christenson	Public Health Rep	1985	3920711	Yes
2319	1409	1409.0	50.42	50.4	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2320	2818	1409.0	142.38	71.2	Sensitivity Analysis in Observational Research: Introducing the E-Value.	Tyler J VanderWeele, Peng Ding	Ann Intern Med	2017	28693043	Yes
2321	7039	1407.8	265.5	53.1	Fsl.	Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith	Neuroimage	2012	21979382	No
2322	2814	1407.0	77.03	38.5	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2323	1407	1407.0	63.18	63.2	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2324	2814	1407.0	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L Hodgkin, B Katz	J Physiol	1949	18128147	Yes
2325	2811	1405.5	69.84	34.9	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2326	2810	1405.0	81.21	40.6	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2327	1405	1405.0	50.68	50.7	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2328	1404	1404.0	32.75	32.8	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2329	2808	1404.0	71.0	35.5	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2330	1404	1404.0	26.18	26.2	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
2331	1404	1404.0	34.13	34.1	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2332	2807	1403.5	85.25	42.6	Molecular and cellular insights into T cell exhaustion.	E John Wherry, Makoto Kurachi	Nat Rev Immunol	2015	26205583	No
2333	1403	1403.0	25.22	25.2	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
2334	2806	1403.0	69.24	34.6	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2335	1402	1402.0	51.21	51.2	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2336	1402	1402.0	33.29	33.3	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2337	2804	1402.0	83.95	42.0	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2338	2804	1402.0	0.0	0.0	Virus interference. I. The interferon.	A Isaacs, J Lindenmann	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2339	2804	1402.0	62.36	31.2	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2340	1402	1402.0	30.54	30.5	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
2341	1401	1401.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E Satterthwaite	Biometrics	1946	20287815	Yes
2342	2801	1400.5	42.04	21.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2343	1400	1400.0	31.95	31.9	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2344	2800	1400.0	55.49	27.7	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2345	1400	1400.0	30.66	30.7	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2346	1400	1400.0	40.47	40.5	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2347	2799	1399.5	68.91	34.5	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2348	1399	1399.0	28.84	28.8	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2349	1399	1399.0	30.25	30.2	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2350	1399	1399.0	33.32	33.3	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2351	1399	1399.0	32.37	32.4	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2352	1399	1399.0	123.8	123.8	A Review of Coronavirus Disease-2019 (COVID-19).	Tanu Singhal	Indian J Pediatr	2020	32166607	No
2353	1398	1398.0	44.39	44.4	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2354	2795	1397.5	82.39	41.2	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2355	2795	1397.5	61.34	30.7	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
2356	4190	1396.7	197.24	65.7	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2357	6980	1396.0	257.59	51.5	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2358	1396	1396.0	29.55	29.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2359	1396	1396.0	44.04	44.0	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2360	4187	1395.7	135.53	45.2	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2361	2791	1395.5	74.61	37.3	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2362	1395	1395.0	17.36	17.4	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2363	1395	1395.0	34.29	34.3	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2364	1395	1395.0	26.98	27.0	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2365	2789	1394.5	81.7	40.9	Microdetermination of long-chain fatty acids in plasma and tissues.	V P Dole, H Meinertz	J Biol Chem	1960	13817286	Yes
2366	2789	1394.5	67.43	33.7	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2367	1394	1394.0	49.99	50.0	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2368	2788	1394.0	65.73	32.9	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2369	5576	1394.0	138.17	34.5	Universal sample preparation method for proteome analysis.	Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2370	2787	1393.5	70.11	35.1	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2371	1393	1393.0	37.1	37.1	Sarcopenia: origins and clinical relevance.	I H Rosenberg	J Nutr	1997	9164280	No
2372	1393	1393.0	29.48	29.5	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2373	2785	1392.5	89.45	44.7	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2374	1392	1392.0	29.94	29.9	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2375	4176	1392.0	83.97	28.0	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2376	4174	1391.3	87.55	29.2	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2377	4174	1391.3	98.95	33.0	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2378	2781	1390.5	108.21	54.1	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2379	2780	1390.0	91.87	45.9	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
2380	1390	1390.0	24.28	24.3	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2381	1389	1389.0	52.8	52.8	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2382	2778	1389.0	80.26	40.1	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2383	5554	1388.5	270.56	67.6	Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range.	Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong	BMC Med Res Methodol	2014	25524443	Yes
2384	4165	1388.3	110.98	37.0	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2385	1388	1388.0	53.61	53.6	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
2386	2774	1387.0	100.85	50.4	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2387	1387	1387.0	57.52	57.5	1,500 scientists lift the lid on reproducibility.	Monya Baker	Nature	2016	27225100	No
2388	6927	1385.4	200.79	40.2	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2389	2770	1385.0	71.45	35.7	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
2390	1385	1385.0	52.19	52.2	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2391	1384	1384.0	30.74	30.7	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2392	2766	1383.0	95.39	47.7	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2393	1382	1382.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C Schneider	J Biol Chem	1948	18886166	Yes
2394	2763	1381.5	63.14	31.6	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
2395	2763	1381.5	61.31	30.7	Immunoassay of endogenous plasma insulin in man.	R S Yalow, S A Berson	J Clin Invest	1960	13846364	Yes
2396	1381	1381.0	32.32	32.3	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2397	1381	1381.0	35.29	35.3	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2398	6903	1380.6	167.56	33.5	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2399	2760	1380.0	94.19	47.1	A new scale of social desirability independent of psychopathology.	D P Crowne, D Marlowe	J Consult Psychol	1960	13813058	Yes
2400	2760	1380.0	36.73	18.4	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A Dahlstroem, K Fuxe	Acta Physiol Scand Suppl	1964	14229500	Yes
2401	1379	1379.0	42.89	42.9	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2402	2758	1379.0	63.59	31.8	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2403	1379	1379.0	31.03	31.0	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2404	1379	1379.0	0.0	0.0	The critical incident technique.	J C Flanagan	Psychol Bull	1954	13177800	Yes
2405	2758	1379.0	65.66	32.8	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2406	5515	1378.8	208.09	52.0	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2407	2753	1376.5	73.93	37.0	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2408	1376	1376.0	59.61	59.6	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2409	2752	1376.0	58.08	29.0	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2410	2752	1376.0	110.1	55.0	A typology of reviews: an analysis of 14 review types and associated methodologies.	Maria J Grant, Andrew Booth	Health Info Libr J	2009	19490148	No
2411	1376	1376.0	48.27	48.3	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
2412	4127	1375.7	91.59	30.5	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2413	2750	1375.0	76.9	38.5	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2414	2749	1374.5	70.39	35.2	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2415	1374	1374.0	29.96	30.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2416	4121	1373.7	100.43	33.5	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2417	1373	1373.0	21.42	21.4	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
2418	1373	1373.0	22.33	22.3	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2419	1373	1373.0	31.56	31.6	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2420	1373	1373.0	63.66	63.7	Biological roles of glycans.	Ajit Varki	Glycobiology	2017	27558841	No
2421	1372	1372.0	39.09	39.1	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2422	1372	1372.0	36.54	36.5	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2423	1372	1372.0	56.53	56.5	Rhythms for Cognition: Communication through Coherence.	Pascal Fries	Neuron	2015	26447583	No
2424	4115	1371.7	141.96	47.3	Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.	Marina Colombo, Graça Raposo, Clotilde Théry	Annu Rev Cell Dev Biol	2014	25288114	No
2425	2743	1371.5	77.22	38.6	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2426	1371	1371.0	25.74	25.7	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2427	9597	1371.0	238.8	34.1	Integrative genomics viewer.	James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov	Nat Biotechnol	2011	21221095	Yes
2428	9596	1370.9	387.81	55.4	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2429	2741	1370.5	54.96	27.5	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
2430	2740	1370.0	68.19	34.1	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2431	2740	1370.0	84.4	42.2	Tumor-associated macrophages: from mechanisms to therapy.	Roy Noy, Jeffrey W Pollard	Immunity	2014	25035953	No
2432	2739	1369.5	80.58	40.3	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2433	2738	1369.0	85.61	42.8	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2434	1368	1368.0	28.34	28.3	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2435	1368	1368.0	30.04	30.0	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2436	1368	1368.0	37.53	37.5	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
2437	1368	1368.0	36.41	36.4	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2438	5472	1368.0	219.82	55.0	QUAST: quality assessment tool for genome assemblies.	Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler	Bioinformatics	2013	23422339	Yes
2439	4101	1367.0	119.48	39.8	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2440	1367	1367.0	27.87	27.9	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2441	2734	1367.0	73.91	37.0	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2442	1367	1367.0	50.84	50.8	Microtiter dish biofilm formation assay.	George A O'Toole	J Vis Exp	2011	21307833	Yes
2443	4099	1366.3	116.82	38.9	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2444	1366	1366.0	29.88	29.9	Measuring information transfer	T Schreiber	Phys Rev Lett	2000	10991308	Yes
2445	1366	1366.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O Smithies	Biochem J	1959	13638269	Yes
2446	1366	1366.0	71.28	71.3	ROS Are Good.	Ron Mittler	Trends Plant Sci	2017	27666517	No
2447	2731	1365.5	92.03	46.0	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
2448	1365	1365.0	46.84	46.8	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2449	1365	1365.0	42.64	42.6	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2450	2730	1365.0	61.74	30.9	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2451	1365	1365.0	28.5	28.5	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2452	2730	1365.0	80.66	40.3	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2453	8188	1364.7	205.61	34.3	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2454	2729	1364.5	59.33	29.7	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2455	1364	1364.0	31.26	31.3	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2456	2728	1364.0	66.35	33.2	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2457	2728	1364.0	66.3	33.1	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2458	1364	1364.0	40.53	40.5	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2459	2728	1364.0	110.01	55.0	The Warburg Effect: How Does it Benefit Cancer Cells?	Maria V Liberti, Jason W Locasale	Trends Biochem Sci	2016	26778478	No
2460	2726	1363.0	95.95	48.0	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2461	2725	1362.5	53.74	26.9	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
2462	2725	1362.5	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B Chance, G R Williams	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
2463	2724	1362.0	56.17	28.1	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
2464	1362	1362.0	52.3	52.3	Minority stress and mental health in gay men.	I H Meyer	J Health Soc Behav	1995	7738327	Yes
2465	1362	1362.0	24.66	24.7	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2466	1361	1361.0	29.13	29.1	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2467	1361	1361.0	46.33	46.3	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
2468	1361	1361.0	29.76	29.8	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2469	1361	1361.0	45.7	45.7	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2470	1361	1361.0	116.28	116.3	The STROBE guidelines.	Sarah Cuschieri	Saudi J Anaesth	2019	30930717	No
2471	1361	1361.0	105.75	105.8	Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.	Jonas F Ludvigsson	Acta Paediatr	2020	32202343	Yes
2472	2721	1360.5	76.16	38.1	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2473	1360	1360.0	32.73	32.7	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
2474	1360	1360.0	43.03	43.0	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2475	1360	1360.0	24.06	24.1	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2476	1360	1360.0	28.11	28.1	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2477	2720	1360.0	85.57	42.8	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2478	1359	1359.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B Caulfield	J Biophys Biochem Cytol	1957	13475399	Yes
2479	2716	1358.0	125.28	62.6	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2480	1358	1358.0	60.24	60.2	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2481	1358	1358.0	31.75	31.8	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2482	1357	1357.0	43.51	43.5	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2483	1356	1356.0	28.69	28.7	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2484	5424	1356.0	233.72	58.4	Progressive statistics for studies in sports medicine and exercise science.	William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin	Med Sci Sports Exerc	2009	19092709	No
2485	2712	1356.0	64.64	32.3	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2486	1355	1355.0	64.76	64.8	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
2487	1355	1355.0	27.45	27.4	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2488	1355	1355.0	34.32	34.3	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2489	1355	1355.0	37.69	37.7	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2490	1355	1355.0	41.81	41.8	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2491	2709	1354.5	55.13	27.6	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2492	1353	1353.0	44.41	44.4	Phenylpropanoid biosynthesis.	Thomas Vogt	Mol Plant	2010	20035037	No
2493	2706	1353.0	72.15	36.1	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2494	2705	1352.5	106.59	53.3	Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.	Roel Nusse, Hans Clevers	Cell	2017	28575679	No
2495	1352	1352.0	34.65	34.6	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2496	1352	1352.0	52.44	52.4	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
2497	2701	1350.5	62.2	31.1	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
2498	6751	1350.2	182.69	36.5	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2499	1350	1350.0	48.32	48.3	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2500	1350	1350.0	56.7	56.7	The Laboratory Rat: Relating Its Age With Human's.	Pallav Sengupta	Int J Prev Med	2013	23930179	Yes
2501	4049	1349.7	49.84	16.6	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D Sabatini, K Bensch, R J Barrnett	J Cell Biol	1963	13975866	Yes
2502	2699	1349.5	93.68	46.8	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2503	6746	1349.2	355.97	71.2	ModelFinder: fast model selection for accurate phylogenetic estimates.	Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin	Nat Methods	2017	28481363	Yes
2504	1349	1349.0	41.18	41.2	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2505	1349	1349.0	39.9	39.9	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2506	1349	1349.0	20.49	20.5	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2507	1349	1349.0	41.39	41.4	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2508	1349	1349.0	25.82	25.8	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2509	1349	1349.0	11.77	11.8	Immunological function of the thymus.	J F Miller	Lancet	1961	14474038	Yes
2510	1348	1348.0	41.48	41.5	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2511	1348	1348.0	26.83	26.8	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2512	1348	1348.0	25.95	25.9	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2513	1347	1347.0	33.63	33.6	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2514	5388	1347.0	126.72	31.7	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2515	5385	1346.2	123.8	30.9	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2516	1346	1346.0	43.83	43.8	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2517	1346	1346.0	64.37	64.4	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2518	1346	1346.0	35.51	35.5	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2519	1345	1345.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J Waddell	J Lab Clin Med	1956	13346201	Yes
2520	1345	1345.0	40.98	41.0	Nanobodies: natural single-domain antibodies.	Serge Muyldermans	Annu Rev Biochem	2013	23495938	No
2521	1344	1344.0	39.82	39.8	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2522	1344	1344.0	73.46	73.5	DLS and zeta potential - What they are and what they are not?	Sourav Bhattacharjee	J Control Release	2016	27297779	No
2523	1344	1344.0	102.8	102.8	The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020.	The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team	China CDC Wkly	2020	34594836	Yes
2524	2686	1343.0	61.25	30.6	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2525	1343	1343.0	30.26	30.3	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2526	1343	1343.0	38.06	38.1	Subcutaneous and visceral adipose tissue: structural and functional differences.	M Mohsen Ibrahim	Obes Rev	2010	19656312	No
2527	1342	1342.0	23.03	23.0	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2528	1341	1341.0	25.64	25.6	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2529	1341	1341.0	27.32	27.3	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2530	2682	1341.0	60.05	30.0	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2531	4021	1340.3	88.01	29.3	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2532	1340	1340.0	35.6	35.6	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2533	1340	1340.0	44.85	44.9	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2534	1340	1340.0	30.2	30.2	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2535	2679	1339.5	61.98	31.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2536	2678	1339.0	88.91	44.5	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
2537	1339	1339.0	35.88	35.9	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2538	4017	1339.0	90.63	30.2	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2539	2675	1337.5	73.16	36.6	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2540	2675	1337.5	64.6	32.3	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2541	1337	1337.0	25.14	25.1	A modified procedure for lead staining of thin sections.	G Millonig	J Biophys Biochem Cytol	1961	14474176	Yes
2542	4010	1336.7	100.47	33.5	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2543	5346	1336.5	117.44	29.4	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2544	1336	1336.0	28.56	28.6	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2545	1336	1336.0	47.12	47.1	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2546	2672	1336.0	67.45	33.7	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2547	2671	1335.5	59.32	29.7	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2548	1335	1335.0	34.89	34.9	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2549	1335	1335.0	41.82	41.8	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2550	1335	1335.0	32.89	32.9	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2551	2669	1334.5	79.85	39.9	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
2552	1334	1334.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B Cloward	J Neurosurg	1958	13599052	Yes
2553	1333	1333.0	48.19	48.2	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2554	1333	1333.0	33.93	33.9	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2555	1333	1333.0	25.68	25.7	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
2556	1333	1333.0	33.28	33.3	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2557	2666	1333.0	53.8	26.9	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2558	1333	1333.0	38.66	38.7	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2559	1333	1333.0	28.41	28.4	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2560	1332	1332.0	30.17	30.2	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2561	1332	1332.0	41.78	41.8	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2562	2664	1332.0	63.29	31.6	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2563	3993	1331.0	102.61	34.2	Cognitive and emotional influences in anterior cingulate cortex.	G Bush, P Luu, M I Posner	Trends Cogn Sci	2000	10827444	Yes
2564	1331	1331.0	23.4	23.4	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2565	2661	1330.5	71.13	35.6	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2566	1330	1330.0	34.62	34.6	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2567	3990	1330.0	107.13	35.7	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2568	2660	1330.0	61.24	30.6	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2569	5317	1329.2	130.47	32.6	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2570	3987	1329.0	102.92	34.3	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2571	7974	1329.0	263.31	43.9	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke	J Clin Epidemiol	2008	18313558	Yes
2572	2656	1328.0	76.09	38.0	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2573	2654	1327.0	55.7	27.9	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2574	1327	1327.0	40.92	40.9	Evaluating the quality of medical care. 1966.	Avedis Donabedian	Milbank Q	2005	16279964	No
2575	5307	1326.8	190.44	47.6	Near-optimal probabilistic RNA-seq quantification.	Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter	Nat Biotechnol	2016	27043002	Yes
2576	2653	1326.5	57.89	28.9	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2577	1326	1326.0	29.95	29.9	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2578	1326	1326.0	37.64	37.6	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2579	3977	1325.7	134.31	44.8	Job burnout.	C Maslach, W B Schaufeli, M P Leiter	Annu Rev Psychol	2001	11148311	Yes
2580	1325	1325.0	0.0	0.0	On the psychophysical law.	S S Stevens	Psychol Rev	1957	13441853	Yes
2581	1325	1325.0	13.19	13.2	Cellular resistance to infection.	G B Mackaness	J Exp Med	1962	14467923	Yes
2582	1324	1324.0	79.93	79.9	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2583	1324	1324.0	23.11	23.1	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2584	1324	1324.0	38.49	38.5	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2585	2647	1323.5	46.6	23.3	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2586	1323	1323.0	50.59	50.6	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2587	2646	1323.0	68.28	34.1	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2588	1323	1323.0	35.58	35.6	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2589	1323	1323.0	32.27	32.3	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2590	2645	1322.5	60.14	30.1	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2591	2645	1322.5	55.9	27.9	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2592	2644	1322.0	100.63	50.3	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
2593	1322	1322.0	38.99	39.0	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2594	1322	1322.0	42.67	42.7	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2595	2644	1322.0	58.06	29.0	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2596	2643	1321.5	118.18	59.1	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2597	6607	1321.4	124.4	24.9	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2598	2642	1321.0	49.07	24.5	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2599	1321	1321.0	54.8	54.8	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2600	3961	1320.3	97.41	32.5	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2601	3961	1320.3	80.79	26.9	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2602	1319	1319.0	22.87	22.9	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
2603	1319	1319.0	34.97	35.0	Levels of racism: a theoretic framework and a gardener's tale.	C P Jones	Am J Public Health	2000	10936998	Yes
2604	1319	1319.0	27.26	27.3	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2605	2637	1318.5	56.7	28.4	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2606	2637	1318.5	77.74	38.9	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2607	3955	1318.3	111.83	37.3	The Patient Health Questionnaire-2: validity of a two-item depression screener.	Kurt Kroenke, Robert L Spitzer, Janet B W Williams	Med Care	2003	14583691	Yes
2608	1318	1318.0	34.13	34.1	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2609	1318	1318.0	35.2	35.2	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2610	1318	1318.0	39.26	39.3	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2611	7907	1317.8	199.43	33.2	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2612	2635	1317.5	101.13	50.6	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2613	3952	1317.3	93.44	31.1	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2614	5269	1317.2	123.73	30.9	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
2615	1317	1317.0	17.08	17.1	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2616	1317	1317.0	31.48	31.5	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2617	1317	1317.0	35.88	35.9	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
2618	3950	1316.7	141.02	47.0	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2619	3949	1316.3	83.55	27.8	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2620	1316	1316.0	28.65	28.6	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2621	1316	1316.0	60.83	60.8	When to use the Bonferroni correction.	Richard A Armstrong	Ophthalmic Physiol Opt	2014	24697967	No
2622	1316	1316.0	41.23	41.2	Function and information content of DNA methylation.	Dirk Schübeler	Nature	2015	25592537	No
2623	3947	1315.7	91.21	30.4	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2624	1315	1315.0	33.4	33.4	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2625	1315	1315.0	40.95	41.0	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2626	5259	1314.8	104.39	26.1	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2627	1314	1314.0	42.0	42.0	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2628	7881	1313.5	196.95	32.8	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2629	1313	1313.0	22.39	22.4	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2630	1313	1313.0	44.42	44.4	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2631	1313	1313.0	33.65	33.6	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2632	1312	1312.0	69.49	69.5	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2633	1312	1312.0	42.22	42.2	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2634	2624	1312.0	67.67	33.8	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2635	2622	1311.0	77.05	38.5	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2636	1311	1311.0	37.28	37.3	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2637	1311	1311.0	39.65	39.6	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2638	2621	1310.5	38.18	19.1	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2639	1310	1310.0	34.59	34.6	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2640	1310	1310.0	24.48	24.5	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2641	1310	1310.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F Scholander	J Biol Chem	1947	20281644	Yes
2642	1310	1310.0	56.86	56.9	Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction.	Alice Y Y Cheng	Can J Diabetes	2013	24070926	No
2643	2619	1309.5	163.17	81.6	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2644	1309	1309.0	37.27	37.3	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2645	2618	1309.0	40.47	20.2	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2646	2618	1309.0	49.16	24.6	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
2647	1309	1309.0	35.75	35.8	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2648	1309	1309.0	33.01	33.0	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2649	1309	1309.0	81.12	81.1	SARS-CoV-2 vaccines in development.	Florian Krammer	Nature	2020	32967006	No
2650	3926	1308.7	87.85	29.3	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2651	2617	1308.5	59.44	29.7	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2652	5234	1308.5	114.73	28.7	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2653	1308	1308.0	27.63	27.6	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2654	1308	1308.0	27.68	27.7	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2655	1308	1308.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J Berkson	Biometrics	1946	21001024	Yes
2656	3923	1307.7	91.29	30.4	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2657	2614	1307.0	40.27	20.1	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2658	1307	1307.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S Farr	J Infect Dis	1958	13611294	Yes
2659	1305	1305.0	31.87	31.9	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2660	1305	1305.0	32.17	32.2	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2661	2610	1305.0	83.67	41.8	The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample.	Julie D Henry, John R Crawford	Br J Clin Psychol	2005	16004657	Yes
2662	1305	1305.0	78.39	78.4	Information bias in health research: definition, pitfalls, and adjustment methods.	Alaa Althubaiti	J Multidiscip Healthc	2016	27217764	No
2663	1304	1304.0	30.11	30.1	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2664	1304	1304.0	24.13	24.1	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2665	1304	1304.0	29.8	29.8	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2666	1304	1304.0	103.89	103.9	COVID-19 and African Americans.	Clyde W Yancy	JAMA	2020	32293639	Yes
2667	6517	1303.4	159.86	32.0	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2668	1303	1303.0	37.94	37.9	Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE.	Louis B Rice	J Infect Dis	2008	18419525	No
2669	2605	1302.5	57.87	28.9	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2670	2605	1302.5	60.28	30.1	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2671	2604	1302.0	43.3	21.6	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2672	1302	1302.0	44.57	44.6	PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints.	Chun Wei Yap	J Comput Chem	2011	21425294	Yes
2673	1301	1301.0	44.62	44.6	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2674	2602	1301.0	64.63	32.3	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
2675	1301	1301.0	28.41	28.4	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2676	2602	1301.0	0.0	0.0	Construct validity in psychological tests.	L J Cronbach, P E Meehl	Psychol Bull	1955	13245896	Yes
2677	2600	1300.0	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A Edmondson, P E Steiner	Cancer	1954	13160935	Yes
2678	1300	1300.0	53.63	53.6	Inflammation, metaflammation and immunometabolic disorders.	Gökhan S Hotamisligil	Nature	2017	28179656	No
2679	6499	1299.8	156.16	31.2	Jalview Version 2--a multiple sequence alignment editor and analysis workbench.	Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton	Bioinformatics	2009	19151095	Yes
2680	1299	1299.0	27.59	27.6	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
2681	1299	1299.0	30.3	30.3	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2682	1299	1299.0	26.99	27.0	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2683	1299	1299.0	47.02	47.0	Energy metabolism in the liver.	Liangyou Rui	Compr Physiol	2014	24692138	No
2684	2597	1298.5	83.25	41.6	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
2685	3895	1298.3	127.24	42.4	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2686	1298	1298.0	35.29	35.3	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2687	1298	1298.0	32.89	32.9	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2688	1298	1298.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2689	1298	1298.0	35.72	35.7	T follicular helper cell differentiation, function, and roles in disease.	Shane Crotty	Immunity	2014	25367570	No
2690	2595	1297.5	69.48	34.7	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2691	1297	1297.0	31.15	31.1	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2692	6481	1296.2	249.83	50.0	The Phyre2 web portal for protein modeling, prediction and analysis.	Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg	Nat Protoc	2015	25950237	Yes
2693	1296	1296.0	30.98	31.0	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
2694	1296	1296.0	36.36	36.4	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2695	1296	1296.0	29.56	29.6	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2696	1296	1296.0	34.37	34.4	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2697	1296	1296.0	39.17	39.2	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2698	2591	1295.5	61.67	30.8	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
2699	5182	1295.5	185.67	46.4	The chemistry and applications of metal-organic frameworks.	Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi	Science	2013	23990564	Yes
2700	2590	1295.0	131.13	65.6	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2701	1295	1295.0	29.54	29.5	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2702	2590	1295.0	67.53	33.8	Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis).	S M Rogers, L Bernatchez	Mol Ecol	2005	15660930	Yes
2703	1295	1295.0	32.15	32.1	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2704	2590	1295.0	58.97	29.5	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2705	2590	1295.0	87.09	43.5	Factors affecting wound healing.	S Guo, L A Dipietro	J Dent Res	2010	20139336	No
2706	6470	1294.0	241.79	48.4	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
2707	1294	1294.0	45.73	45.7	Plasma perspective on strong field multiphoton ionization.	P B Corkum	Phys Rev Lett	1993	10054556	Yes
2708	1294	1294.0	23.36	23.4	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2709	1294	1294.0	22.53	22.5	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2710	1294	1294.0	29.24	29.2	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
2711	1292	1292.0	42.57	42.6	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2712	1292	1292.0	61.5	61.5	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
2713	1292	1292.0	27.07	27.1	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2714	2583	1291.5	55.4	27.7	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2715	1291	1291.0	42.22	42.2	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
2716	2582	1291.0	71.25	35.6	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2717	1291	1291.0	24.07	24.1	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
2718	2581	1290.5	45.88	22.9	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2719	3871	1290.3	97.18	32.4	Atomic force microscope.	G Binnig, C F Quate, C Gerber	Phys Rev Lett	1986	10033323	Yes
2720	1290	1290.0	26.97	27.0	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
2721	1290	1290.0	35.53	35.5	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2722	1290	1290.0	37.24	37.2	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2723	2578	1289.0	98.09	49.0	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
2724	14179	1289.0	380.83	34.6	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2725	1288	1288.0	43.45	43.5	Density matrix formulation for quantum renormalization groups.	S R White	Phys Rev Lett	1992	10046608	Yes
2726	2576	1288.0	94.4	47.2	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
2727	1287	1287.0	31.71	31.7	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2728	2573	1286.5	88.61	44.3	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2729	1286	1286.0	38.93	38.9	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2730	1286	1286.0	37.06	37.1	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
2731	1286	1286.0	10.68	10.7	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2732	1286	1286.0	46.95	47.0	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2733	1286	1286.0	42.84	42.8	Enhancing the quality and credibility of qualitative analysis.	M Q Patton	Health Serv Res	1999	10591279	No
2734	2572	1286.0	63.52	31.8	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2735	2572	1286.0	46.62	23.3	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2736	3858	1286.0	143.23	47.7	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
2737	14144	1285.8	362.74	33.0	Frailty in older adults: evidence for a phenotype.	L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie	J Gerontol A Biol Sci Med Sci	2001	11253156	Yes
2738	2570	1285.0	89.21	44.6	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2739	1285	1285.0	30.35	30.4	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
2740	3853	1284.3	74.2	24.7	Exosomes: composition, biogenesis and function.	Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
2741	2568	1284.0	51.91	26.0	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2742	2567	1283.5	215.46	107.7	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2743	1283	1283.0	61.0	61.0	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2744	1283	1283.0	34.6	34.6	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2745	2565	1282.5	54.68	27.3	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2746	2565	1282.5	248.32	124.2	Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.	David J Newman, Gordon M Cragg	J Nat Prod	2020	32162523	No
2747	8974	1282.0	308.0	44.0	Metagenomic biomarker discovery and explanation.	Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower	Genome Biol	2011	21702898	Yes
2748	2563	1281.5	60.74	30.4	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2749	3844	1281.3	171.98	57.3	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2750	8969	1281.3	251.27	35.9	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2751	1281	1281.0	21.74	21.7	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2752	1281	1281.0	33.48	33.5	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2753	1281	1281.0	41.17	41.2	Photoplethysmography and its application in clinical physiological measurement.	John Allen	Physiol Meas	2007	17322588	No
2754	1281	1281.0	36.01	36.0	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2755	2561	1280.5	66.0	33.0	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
2756	2561	1280.5	156.67	78.3	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2757	2561	1280.5	52.58	26.3	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2758	1280	1280.0	31.67	31.7	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2759	2560	1280.0	79.29	39.6	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2760	2560	1280.0	98.81	49.4	Unique features of long non-coding RNA biogenesis and function.	Jeffrey J Quinn, Howard Y Chang	Nat Rev Genet	2016	26666209	No
2761	3839	1279.7	90.92	30.3	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2762	6398	1279.6	253.93	50.8	Integrating single-cell transcriptomic data across different conditions, technologies, and species.	Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija	Nat Biotechnol	2018	29608179	Yes
2763	2559	1279.5	81.93	41.0	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2764	2559	1279.5	66.96	33.5	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2765	1279	1279.0	28.96	29.0	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2766	1279	1279.0	56.01	56.0	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2767	1279	1279.0	0.0	0.0	Agammaglobulinemia.	O C Bruton	Pediatrics	1952	14929630	Yes
2768	1279	1279.0	31.29	31.3	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2769	1278	1278.0	42.43	42.4	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2770	2555	1277.5	61.37	30.7	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2771	1277	1277.0	39.5	39.5	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
2772	2554	1277.0	62.71	31.4	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2773	1277	1277.0	32.01	32.0	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2774	1276	1276.0	34.56	34.6	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2775	1276	1276.0	36.22	36.2	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2776	2552	1276.0	88.77	44.4	Nitric oxide synthases: regulation and function.	Ulrich Förstermann, William C Sessa	Eur Heart J	2012	21890489	No
2777	1275	1275.0	28.69	28.7	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2778	1275	1275.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M Kalckar	J Biol Chem	1947	20285041	Yes
2779	2549	1274.5	23.61	11.8	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2780	2548	1274.0	49.0	24.5	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2781	1274	1274.0	47.37	47.4	Glutathione synthesis.	Shelly C Lu	Biochim Biophys Acta	2013	22995213	No
2782	2547	1273.5	66.0	33.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
2783	5093	1273.2	188.81	47.2	Predicting effective microRNA target sites in mammalian mRNAs.	Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel	Elife	2015	26267216	Yes
2784	1273	1273.0	31.65	31.6	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2785	1273	1273.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B Verney	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
2786	1273	1273.0	82.22	82.2	Epidemiology of Prostate Cancer.	Prashanth Rawla	World J Oncol	2019	31068988	No
2787	20363	1272.7	572.97	35.8	New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).	E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij	Eur J Cancer	2009	19097774	No
2788	2545	1272.5	64.23	32.1	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
2789	2544	1272.0	76.11	38.1	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2790	1272	1272.0	33.18	33.2	Bacteroides: the good, the bad, and the nitty-gritty.	Hannah M Wexler	Clin Microbiol Rev	2007	17934076	No
2791	2543	1271.5	49.03	24.5	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2792	3814	1271.3	112.97	37.7	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
2793	5085	1271.2	116.73	29.2	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2794	8898	1271.1	262.77	37.5	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
2795	3813	1271.0	103.64	34.5	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2796	1271	1271.0	29.49	29.5	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
2797	1270	1270.0	45.28	45.3	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2798	1270	1270.0	25.5	25.5	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
2799	1270	1270.0	31.56	31.6	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
2800	2539	1269.5	50.44	25.2	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2801	3807	1269.0	112.39	37.5	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2802	1269	1269.0	32.19	32.2	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2803	1269	1269.0	33.97	34.0	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2804	1268	1268.0	32.44	32.4	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2805	1268	1268.0	30.08	30.1	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2806	3803	1267.7	118.71	39.6	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2807	1267	1267.0	35.19	35.2	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2808	2534	1267.0	66.63	33.3	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2809	1267	1267.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A Berg	J Gen Psychol	1948	18889466	Yes
2810	1267	1267.0	26.88	26.9	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2811	1267	1267.0	56.05	56.0	The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health.	Lisa Bowleg	Am J Public Health	2012	22594719	Yes
2812	1266	1266.0	28.24	28.2	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2813	2532	1266.0	51.04	25.5	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2814	2531	1265.5	13.33	6.7	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J Todaro, H Green	J Cell Biol	1963	13985244	Yes
2815	2530	1265.0	56.96	28.5	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2816	1265	1265.0	35.69	35.7	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
2817	1264	1264.0	62.97	63.0	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2818	2528	1264.0	44.24	22.1	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2819	7581	1263.5	217.41	36.2	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2820	2526	1263.0	67.38	33.7	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2821	1263	1263.0	14.07	14.1	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
2822	2526	1263.0	88.62	44.3	Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.	John F Cryan, Timothy G Dinan	Nat Rev Neurosci	2012	22968153	No
2823	1262	1262.0	49.12	49.1	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
2824	1262	1262.0	26.71	26.7	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2825	2524	1262.0	56.0	28.0	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2826	1262	1262.0	41.96	42.0	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2827	2524	1262.0	96.04	48.0	Kraken: ultrafast metagenomic sequence classification using exact alignments.	Derrick E Wood, Steven L Salzberg	Genome Biol	2014	24580807	Yes
2828	2523	1261.5	63.39	31.7	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2829	1261	1261.0	44.95	45.0	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2830	1261	1261.0	30.41	30.4	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2831	1261	1261.0	25.92	25.9	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
2832	1261	1261.0	25.73	25.7	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2833	1261	1261.0	26.74	26.7	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2834	2522	1261.0	49.94	25.0	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
2835	1261	1261.0	39.65	39.6	The Danish Register of Causes of Death.	Karin Helweg-Larsen	Scand J Public Health	2011	21775346	Yes
2836	1260	1260.0	33.88	33.9	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
2837	2519	1259.5	47.15	23.6	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2838	3778	1259.3	89.78	29.9	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2839	5036	1259.0	144.27	36.1	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2840	1259	1259.0	36.09	36.1	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2841	1259	1259.0	30.61	30.6	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2842	1259	1259.0	28.6	28.6	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2843	2517	1258.5	73.16	36.6	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2844	2517	1258.5	48.39	24.2	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2845	1258	1258.0	25.7	25.7	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2846	1258	1258.0	44.54	44.5	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
2847	2516	1258.0	48.79	24.4	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2848	1258	1258.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M Reitan	J Consult Psychol	1955	13263471	Yes
2849	2516	1258.0	68.78	34.4	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2850	2516	1258.0	64.28	32.1	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2851	2515	1257.5	76.67	38.3	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
2852	5028	1257.0	283.51	70.9	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
2853	2514	1257.0	61.67	30.8	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2854	1257	1257.0	42.83	42.8	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2855	1257	1257.0	30.4	30.4	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2856	5027	1256.8	105.06	26.3	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2857	1256	1256.0	45.71	45.7	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2858	1256	1256.0	20.63	20.6	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A Rose	Bull World Health Organ	1962	13974778	Yes
2859	5024	1256.0	131.38	32.8	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2860	1256	1256.0	59.93	59.9	The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.	Costantino Iadecola	Neuron	2017	28957666	No
2861	1255	1255.0	52.64	52.6	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2862	2509	1254.5	49.68	24.8	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2863	3763	1254.3	184.95	61.6	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
2864	7526	1254.3	208.91	34.8	Genome engineering using the CRISPR-Cas9 system.	F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang	Nat Protoc	2013	24157548	Yes
2865	1254	1254.0	82.88	82.9	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2866	1254	1254.0	31.48	31.5	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
2867	1254	1254.0	27.78	27.8	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2868	1254	1254.0	25.97	26.0	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2869	13793	1253.9	327.36	29.8	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2870	10029	1253.6	255.0	31.9	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
2871	1253	1253.0	34.48	34.5	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
2872	1253	1253.0	32.32	32.3	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2873	1253	1253.0	30.44	30.4	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2874	1253	1253.0	27.02	27.0	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2875	1253	1253.0	32.12	32.1	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2876	1253	1253.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J Bateman	Heredity (Edinb)	1948	18103134	Yes
2877	1253	1253.0	39.26	39.3	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2878	1253	1253.0	38.39	38.4	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
2879	2505	1252.5	56.14	28.1	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2880	3757	1252.3	112.22	37.4	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2881	1252	1252.0	42.19	42.2	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
2882	1252	1252.0	24.81	24.8	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2883	1252	1252.0	29.36	29.4	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2884	2503	1251.5	57.81	28.9	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
2885	2502	1251.0	66.79	33.4	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2886	1251	1251.0	50.05	50.0	The variable nature of cognitive control: a dual mechanisms framework.	Todd S Braver	Trends Cogn Sci	2012	22245618	Yes
2887	2501	1250.5	61.5	30.8	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2888	3751	1250.3	103.71	34.6	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2889	2500	1250.0	53.28	26.6	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2890	2499	1249.5	68.79	34.4	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2891	3748	1249.3	87.76	29.3	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2892	1249	1249.0	57.7	57.7	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2893	1249	1249.0	24.54	24.5	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2894	4995	1248.8	159.12	39.8	Validation of a combined comorbidity index.	M Charlson, T P Szatrowski, J Peterson, J Gold	J Clin Epidemiol	1994	7722560	Yes
2895	1248	1248.0	20.54	20.5	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2896	1248	1248.0	31.71	31.7	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
2897	2495	1247.5	62.57	31.3	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2898	1247	1247.0	33.6	33.6	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2899	3740	1246.7	78.17	26.1	Computer visualization of three-dimensional image data using IMOD.	J R Kremer, D N Mastronarde, J R McIntosh	J Struct Biol	1996	8742726	Yes
2900	2493	1246.5	91.15	45.6	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
2901	2493	1246.5	43.75	21.9	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2902	2493	1246.5	64.45	32.2	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2903	1246	1246.0	38.41	38.4	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
2904	1246	1246.0	31.43	31.4	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2905	1245	1245.0	22.64	22.6	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2906	2488	1244.0	63.1	31.6	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2907	1244	1244.0	27.52	27.5	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2908	1244	1244.0	32.54	32.5	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2909	1244	1244.0	35.86	35.9	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2910	3732	1244.0	114.55	38.2	Evaluating the public health impact of health promotion interventions: the RE-AIM framework.	R E Glasgow, T M Vogt, S M Boles	Am J Public Health	1999	10474547	No
2911	2488	1244.0	63.09	31.5	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2912	1244	1244.0	0.0	0.0	A modification of receptor theory.	R P Stephenson	Br J Pharmacol Chemother	1956	13383117	Yes
2913	1244	1244.0	29.05	29.1	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2914	1244	1244.0	45.74	45.7	Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis.	George S Bloom	JAMA Neurol	2014	24493463	No
2915	2486	1243.0	76.68	38.3	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2916	2486	1243.0	47.79	23.9	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2917	1243	1243.0	30.0	30.0	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
2918	1243	1243.0	24.65	24.6	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2919	1243	1243.0	33.0	33.0	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
2920	1243	1243.0	0.0	0.0	Sequential tests for the detection of linkage.	N E Morton	Am J Hum Genet	1955	13258560	Yes
2921	1243	1243.0	55.53	55.5	Salience processing and insular cortical function and dysfunction.	Lucina Q Uddin	Nat Rev Neurosci	2015	25406711	No
2922	7454	1242.3	278.46	46.4	Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science.	Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery	Implement Sci	2009	19664226	Yes
2923	1242	1242.0	64.56	64.6	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2924	1242	1242.0	42.07	42.1	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
2925	1242	1242.0	35.39	35.4	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2926	3726	1242.0	116.91	39.0	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
2927	1242	1242.0	67.61	67.6	Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV.	Douglas A Drossman	Gastroenterology	2016	27144617	Yes
2928	3725	1241.7	115.73	38.6	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2929	2483	1241.5	102.92	51.5	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2930	1241	1241.0	29.81	29.8	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
2931	1241	1241.0	52.69	52.7	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2932	2481	1240.5	57.44	28.7	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2933	2481	1240.5	216.31	108.2	The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.	Hussin A Rothan, Siddappa N Byrareddy	J Autoimmun	2020	32113704	No
2934	1240	1240.0	37.41	37.4	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2935	1240	1240.0	45.52	45.5	The evolving concept of health literacy.	Don Nutbeam	Soc Sci Med	2008	18952344	Yes
2936	2479	1239.5	63.72	31.9	The ubiquitin code.	David Komander, Michael Rape	Annu Rev Biochem	2012	22524316	No
2937	2478	1239.0	99.98	50.0	Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species.	R Vilgalys, M Hester	J Bacteriol	1990	2376561	Yes
2938	2478	1239.0	61.32	30.7	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2939	1239	1239.0	24.31	24.3	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2940	2476	1238.0	59.36	29.7	Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.	R P Rao, D H Ballard	Nat Neurosci	1999	10195184	Yes
2941	3713	1237.7	221.6	73.9	Production, use, and fate of all plastics ever made.	Roland Geyer, Jenna R Jambeck, Kara Lavender Law	Sci Adv	2017	28776036	Yes
2942	2475	1237.5	53.08	26.5	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N Ames, D T Dubin	J Biol Chem	1960	13793161	Yes
2943	2475	1237.5	73.03	36.5	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
2944	1237	1237.0	37.22	37.2	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
2945	1237	1237.0	32.44	32.4	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2946	1237	1237.0	47.85	47.9	The biology and function of exosomes in cancer.	Raghu Kalluri	J Clin Invest	2016	27035812	No
2947	1236	1236.0	27.48	27.5	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2948	1236	1236.0	30.29	30.3	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
2949	1236	1236.0	38.04	38.0	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2950	2469	1234.5	48.25	24.1	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2951	4937	1234.2	130.4	32.6	Organometal halide perovskites as visible-light sensitizers for photovoltaic cells.	Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka	J Am Chem Soc	2009	19366264	Yes
2952	1234	1234.0	38.78	38.8	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
2953	2468	1234.0	65.8	32.9	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2954	2466	1233.0	68.25	34.1	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2955	2466	1233.0	64.79	32.4	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2956	1233	1233.0	28.7	28.7	Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology.	Christopher Paul Wild	Cancer Epidemiol Biomarkers Prev	2005	16103423	No
2957	1233	1233.0	74.81	74.8	Non-alcoholic fatty liver disease - A global public health perspective.	Zobair M Younossi	J Hepatol	2019	30414863	No
2958	1232	1232.0	22.18	22.2	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2959	1232	1232.0	42.39	42.4	Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.	K Tamura	Mol Biol Evol	1992	1630306	Yes
2960	1232	1232.0	26.31	26.3	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2961	1232	1232.0	24.53	24.5	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
2962	2463	1231.5	39.52	19.8	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2963	1231	1231.0	22.59	22.6	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2964	1231	1231.0	33.86	33.9	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2965	4924	1231.0	135.54	33.9	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.	Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan	Nat Cell Biol	2011	21258367	Yes
2966	1230	1230.0	44.29	44.3	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2967	6150	1230.0	192.43	38.5	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2968	1230	1230.0	28.0	28.0	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2969	1230	1230.0	32.01	32.0	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
2970	2459	1229.5	65.75	32.9	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2971	1229	1229.0	55.41	55.4	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
2972	11056	1228.4	280.52	31.2	MolProbity: all-atom structure validation for macromolecular crystallography.	Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson	Acta Crystallogr D Biol Crystallogr	2010	20057044	Yes
2973	1228	1228.0	49.19

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