No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
---|---|---|---|---|---|---|---|---|---|---|
1 | 224594 | 224594.0 | 4913.95 | 4913.9 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
2 | 173870 | 173870.0 | 6868.45 | 6868.4 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
3 | 286062 | 71515.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
4 | 123889 | 61944.5 | 3076.47 | 1538.2 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
5 | 45349 | 45349.0 | 1391.93 | 1391.9 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
6 | 36974 | 36974.0 | 1191.63 | 1191.6 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
7 | 64456 | 32228.0 | 1931.46 | 965.7 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
8 | 30237 | 30237.0 | 822.68 | 822.7 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
9 | 27980 | 27980.0 | 881.83 | 881.8 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
10 | 27932 | 27932.0 | 614.17 | 614.2 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
11 | 27350 | 27350.0 | 644.92 | 644.9 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
12 | 26112 | 26112.0 | 674.2 | 674.2 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
13 | 24851 | 24851.0 | 569.58 | 569.6 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
14 | 24502 | 24502.0 | 763.44 | 763.4 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
15 | 66690 | 22230.0 | 2447.42 | 815.8 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
16 | 66020 | 22006.7 | 1640.41 | 546.8 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
17 | 43345 | 21672.5 | 1339.31 | 669.7 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
18 | 20292 | 20292.0 | 204.7 | 204.7 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
19 | 40419 | 20209.5 | 1247.94 | 624.0 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
20 | 20097 | 20097.0 | 690.67 | 690.7 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
21 | 19623 | 19623.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
22 | 18471 | 18471.0 | 513.76 | 513.8 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
23 | 36661 | 18330.5 | 1728.14 | 864.1 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
24 | 36608 | 18304.0 | 1517.9 | 759.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
25 | 53507 | 17835.7 | 1993.39 | 664.5 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
26 | 17444 | 17444.0 | 734.18 | 734.2 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
27 | 17392 | 17392.0 | 639.93 | 639.9 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
28 | 16999 | 16999.0 | 426.32 | 426.3 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
29 | 16752 | 16752.0 | 283.78 | 283.8 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
30 | 16717 | 16717.0 | 688.52 | 688.5 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
31 | 32550 | 16275.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
32 | 16207 | 16207.0 | 448.22 | 448.2 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
33 | 48062 | 16020.7 | 1770.32 | 590.1 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
34 | 31917 | 15958.5 | 1009.17 | 504.6 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
35 | 15925 | 15925.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
36 | 46800 | 15600.0 | 1383.2 | 461.1 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
37 | 31152 | 15576.0 | 784.99 | 392.5 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
38 | 15468 | 15468.0 | 386.69 | 386.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
39 | 30563 | 15281.5 | 1220.33 | 610.2 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
40 | 45515 | 15171.7 | 1298.79 | 432.9 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
41 | 29917 | 14958.5 | 1119.04 | 559.5 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
42 | 14489 | 14489.0 | 564.62 | 564.6 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
43 | 42119 | 14039.7 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
44 | 13309 | 13309.0 | 673.62 | 673.6 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
45 | 64050 | 12810.0 | 1838.0 | 367.6 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
46 | 25334 | 12667.0 | 521.36 | 260.7 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
47 | 25259 | 12629.5 | 690.82 | 345.4 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
48 | 12629 | 12629.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
49 | 25159 | 12579.5 | 1029.43 | 514.7 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
50 | 12555 | 12555.0 | 318.96 | 319.0 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
51 | 12534 | 12534.0 | 399.61 | 399.6 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
52 | 12221 | 12221.0 | 561.63 | 561.6 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
53 | 12210 | 12210.0 | 368.56 | 368.6 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
54 | 12070 | 12070.0 | 137.94 | 137.9 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
55 | 24115 | 12057.5 | 650.4 | 325.2 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
56 | 36070 | 12023.3 | 1272.91 | 424.3 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
57 | 23943 | 11971.5 | 521.8 | 260.9 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
58 | 11776 | 11776.0 | 387.6 | 387.6 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
59 | 35215 | 11738.3 | 1363.06 | 454.4 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
60 | 11315 | 11315.0 | 392.37 | 392.4 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
61 | 11286 | 11286.0 | 450.77 | 450.8 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
62 | 11095 | 11095.0 | 422.34 | 422.3 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
63 | 21975 | 10987.5 | 838.61 | 419.3 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
64 | 21563 | 10781.5 | 557.91 | 279.0 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
65 | 31934 | 10644.7 | 829.28 | 276.4 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
66 | 31815 | 10605.0 | 1067.95 | 356.0 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
67 | 21134 | 10567.0 | 454.55 | 227.3 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
68 | 10538 | 10538.0 | 364.65 | 364.6 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
69 | 21033 | 10516.5 | 460.8 | 230.4 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Methods Enzymol | 1997 | 27799103 | Yes |
70 | 20991 | 10495.5 | 895.54 | 447.8 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
71 | 41761 | 10440.2 | 1189.97 | 297.5 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
72 | 10296 | 10296.0 | 201.66 | 201.7 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
73 | 41059 | 10264.8 | 1582.05 | 395.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med | 2009 | 19621072 | No |
74 | 10144 | 10144.0 | 454.88 | 454.9 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
75 | 10018 | 10018.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
76 | 19799 | 9899.5 | 372.57 | 186.3 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
77 | 9751 | 9751.0 | 417.22 | 417.2 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
78 | 9703 | 9703.0 | 273.38 | 273.4 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
79 | 9636 | 9636.0 | 199.22 | 199.2 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
80 | 9624 | 9624.0 | 254.94 | 254.9 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
81 | 19032 | 9516.0 | 491.26 | 245.6 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
82 | 9478 | 9478.0 | 317.97 | 318.0 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
83 | 9414 | 9414.0 | 273.37 | 273.4 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
84 | 9404 | 9404.0 | 248.85 | 248.8 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
85 | 9345 | 9345.0 | 269.48 | 269.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
86 | 9302 | 9302.0 | 240.67 | 240.7 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
87 | 37080 | 9270.0 | 1356.21 | 339.1 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
88 | 9255 | 9255.0 | 263.07 | 263.1 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
89 | 9174 | 9174.0 | 259.06 | 259.1 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
90 | 18301 | 9150.5 | 382.08 | 191.0 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
91 | 9041 | 9041.0 | 233.05 | 233.1 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
92 | 26812 | 8937.3 | 683.49 | 227.8 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
93 | 17801 | 8900.5 | 466.78 | 233.4 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
94 | 8895 | 8895.0 | 214.52 | 214.5 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
95 | 35540 | 8885.0 | 1147.59 | 286.9 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
96 | 53050 | 8841.7 | 3410.45 | 568.4 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
97 | 8782 | 8782.0 | 177.05 | 177.1 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
98 | 8762 | 8762.0 | 227.87 | 227.9 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
99 | 8759 | 8759.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
100 | 17358 | 8679.0 | 379.94 | 190.0 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
101 | 25730 | 8576.7 | 680.94 | 227.0 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
102 | 8555 | 8555.0 | 181.06 | 181.1 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
103 | 8495 | 8495.0 | 221.98 | 222.0 | Canonical dynamics: Equilibrium phase-space distributions. | W G Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
104 | 8433 | 8433.0 | 356.89 | 356.9 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
105 | 8368 | 8368.0 | 412.65 | 412.6 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
106 | 8323 | 8323.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
107 | 8305 | 8305.0 | 216.98 | 217.0 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
108 | 8296 | 8296.0 | 244.78 | 244.8 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
109 | 24888 | 8296.0 | 1370.04 | 456.7 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
110 | 24402 | 8134.0 | 718.98 | 239.7 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
111 | 8094 | 8094.0 | 196.13 | 196.1 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
112 | 7951 | 7951.0 | 367.48 | 367.5 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
113 | 7873 | 7873.0 | 217.75 | 217.8 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
114 | 7856 | 7856.0 | 212.16 | 212.2 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
115 | 15675 | 7837.5 | 372.06 | 186.0 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
116 | 15656 | 7828.0 | 381.1 | 190.6 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
117 | 7798 | 7798.0 | 224.53 | 224.5 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
118 | 15594 | 7797.0 | 350.14 | 175.1 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
119 | 7786 | 7786.0 | 216.27 | 216.3 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
120 | 54229 | 7747.0 | 7344.73 | 1049.2 | Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. | Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray | CA Cancer J Clin | 2021 | 33538338 | Yes |
121 | 7730 | 7730.0 | 151.55 | 151.6 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
122 | 15286 | 7643.0 | 512.63 | 256.3 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
123 | 7638 | 7638.0 | 188.21 | 188.2 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
124 | 7635 | 7635.0 | 220.25 | 220.2 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
125 | 7634 | 7634.0 | 219.25 | 219.2 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
126 | 22792 | 7597.3 | 687.99 | 229.3 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
127 | 7582 | 7582.0 | 161.68 | 161.7 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
128 | 22607 | 7535.7 | 883.5 | 294.5 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
129 | 51662 | 7380.3 | 1329.81 | 190.0 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
130 | 7369 | 7369.0 | 232.8 | 232.8 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
131 | 7364 | 7364.0 | 124.11 | 124.1 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
132 | 7341 | 7341.0 | 242.66 | 242.7 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
133 | 14628 | 7314.0 | 447.79 | 223.9 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
134 | 7305 | 7305.0 | 220.01 | 220.0 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
135 | 28913 | 7228.2 | 946.25 | 236.6 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
136 | 7062 | 7062.0 | 192.27 | 192.3 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
137 | 7042 | 7042.0 | 247.28 | 247.3 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
138 | 13913 | 6956.5 | 327.46 | 163.7 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
139 | 13763 | 6881.5 | 352.51 | 176.3 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
140 | 6837 | 6837.0 | 183.45 | 183.4 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
141 | 6722 | 6722.0 | 176.79 | 176.8 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
142 | 6705 | 6705.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
143 | 13384 | 6692.0 | 725.95 | 363.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
144 | 13180 | 6590.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
145 | 13152 | 6576.0 | 307.99 | 154.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
146 | 19689 | 6563.0 | 551.9 | 184.0 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
147 | 6561 | 6561.0 | 214.04 | 214.0 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
148 | 6549 | 6549.0 | 172.52 | 172.5 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
149 | 6542 | 6542.0 | 129.34 | 129.3 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
150 | 13023 | 6511.5 | 360.96 | 180.5 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
151 | 6511 | 6511.0 | 168.77 | 168.8 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
152 | 6493 | 6493.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
153 | 6404 | 6404.0 | 112.72 | 112.7 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
154 | 6398 | 6398.0 | 128.99 | 129.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
155 | 6385 | 6385.0 | 150.28 | 150.3 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | No |
156 | 6354 | 6354.0 | 134.97 | 135.0 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
157 | 12678 | 6339.0 | 351.77 | 175.9 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
158 | 12641 | 6320.5 | 505.78 | 252.9 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
159 | 12638 | 6319.0 | 431.56 | 215.8 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
160 | 6312 | 6312.0 | 216.07 | 216.1 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
161 | 12542 | 6271.0 | 844.39 | 422.2 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
162 | 6248 | 6248.0 | 135.99 | 136.0 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
163 | 6209 | 6209.0 | 146.2 | 146.2 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
164 | 6206 | 6206.0 | 142.41 | 142.4 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
165 | 6155 | 6155.0 | 143.66 | 143.7 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | No |
166 | 6141 | 6141.0 | 114.63 | 114.6 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
167 | 12249 | 6124.5 | 436.27 | 218.1 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
168 | 18343 | 6114.3 | 912.76 | 304.3 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
169 | 6097 | 6097.0 | 270.99 | 271.0 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
170 | 18288 | 6096.0 | 641.49 | 213.8 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
171 | 6090 | 6090.0 | 149.03 | 149.0 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
172 | 6033 | 6033.0 | 152.25 | 152.2 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
173 | 6032 | 6032.0 | 151.93 | 151.9 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
174 | 6032 | 6032.0 | 145.58 | 145.6 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | No |
175 | 23970 | 5992.5 | 774.6 | 193.7 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
176 | 11939 | 5969.5 | 290.46 | 145.2 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
177 | 5930 | 5930.0 | 136.72 | 136.7 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
178 | 5880 | 5880.0 | 278.09 | 278.1 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
179 | 11712 | 5856.0 | 268.95 | 134.5 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
180 | 11683 | 5841.5 | 318.26 | 159.1 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
181 | 11673 | 5836.5 | 253.81 | 126.9 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
182 | 5815 | 5815.0 | 76.16 | 76.2 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
183 | 5812 | 5812.0 | 178.55 | 178.6 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
184 | 11517 | 5758.5 | 303.67 | 151.8 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
185 | 5703 | 5703.0 | 142.74 | 142.7 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
186 | 11403 | 5701.5 | 193.93 | 97.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
187 | 5695 | 5695.0 | 126.04 | 126.0 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
188 | 11380 | 5690.0 | 250.65 | 125.3 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
189 | 5686 | 5686.0 | 158.86 | 158.9 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
190 | 11278 | 5639.0 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
191 | 5633 | 5633.0 | 184.34 | 184.3 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
192 | 5605 | 5605.0 | 177.22 | 177.2 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
193 | 5597 | 5597.0 | 137.75 | 137.8 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
194 | 5583 | 5583.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
195 | 5582 | 5582.0 | 106.79 | 106.8 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
196 | 5549 | 5549.0 | 221.23 | 221.2 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
197 | 5537 | 5537.0 | 92.65 | 92.7 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
198 | 5513 | 5513.0 | 119.35 | 119.3 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
199 | 5511 | 5511.0 | 92.73 | 92.7 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
200 | 10991 | 5495.5 | 254.74 | 127.4 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
201 | 10990 | 5495.0 | 364.25 | 182.1 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
202 | 16439 | 5479.7 | 494.17 | 164.7 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
203 | 10951 | 5475.5 | 231.44 | 115.7 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
204 | 10948 | 5474.0 | 920.16 | 460.1 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
205 | 10926 | 5463.0 | 287.18 | 143.6 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
206 | 10913 | 5456.5 | 277.83 | 138.9 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
207 | 5420 | 5420.0 | 164.85 | 164.8 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
208 | 5358 | 5358.0 | 121.43 | 121.4 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
209 | 10704 | 5352.0 | 300.1 | 150.1 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
210 | 5336 | 5336.0 | 140.34 | 140.3 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
211 | 5335 | 5335.0 | 136.77 | 136.8 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
212 | 5328 | 5328.0 | 157.58 | 157.6 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
213 | 5305 | 5305.0 | 201.65 | 201.7 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
214 | 5299 | 5299.0 | 134.93 | 134.9 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
215 | 5294 | 5294.0 | 102.76 | 102.8 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
216 | 10587 | 5293.5 | 495.29 | 247.6 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
217 | 26453 | 5290.6 | 714.32 | 142.9 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
218 | 10578 | 5289.0 | 230.72 | 115.4 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
219 | 15864 | 5288.0 | 594.18 | 198.1 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
220 | 10576 | 5288.0 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
221 | 5280 | 5280.0 | 127.53 | 127.5 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
222 | 5265 | 5265.0 | 142.82 | 142.8 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
223 | 5260 | 5260.0 | 151.76 | 151.8 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
224 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
225 | 5213 | 5213.0 | 53.48 | 53.5 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
226 | 15601 | 5200.3 | 384.28 | 128.1 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
227 | 5200 | 5200.0 | 188.78 | 188.8 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
228 | 5191 | 5191.0 | 66.12 | 66.1 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
229 | 31119 | 5186.5 | 1086.18 | 181.0 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
230 | 20658 | 5164.5 | 524.58 | 131.1 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
231 | 10300 | 5150.0 | 365.26 | 182.6 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
232 | 5122 | 5122.0 | 124.35 | 124.3 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
233 | 5104 | 5104.0 | 101.67 | 101.7 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
234 | 10201 | 5100.5 | 241.95 | 121.0 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
235 | 5100 | 5100.0 | 102.07 | 102.1 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
236 | 10198 | 5099.0 | 270.51 | 135.3 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
237 | 5083 | 5083.0 | 197.37 | 197.4 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
238 | 5077 | 5077.0 | 186.9 | 186.9 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
239 | 10137 | 5068.5 | 219.21 | 109.6 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
240 | 4991 | 4991.0 | 231.66 | 231.7 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
241 | 14962 | 4987.3 | 1008.49 | 336.2 | Cancer statistics, 2019. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2019 | 30620402 | Yes |
242 | 14939 | 4979.7 | 539.82 | 179.9 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
243 | 24851 | 4970.2 | 1075.38 | 215.1 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
244 | 9907 | 4953.5 | 235.85 | 117.9 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
245 | 4951 | 4951.0 | 129.38 | 129.4 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
246 | 4923 | 4923.0 | 110.88 | 110.9 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
247 | 4910 | 4910.0 | 179.94 | 179.9 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
248 | 4909 | 4909.0 | 140.42 | 140.4 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
249 | 14703 | 4901.0 | 1236.77 | 412.3 | Cancer statistics, 2020. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2020 | 31912902 | Yes |
250 | 9797 | 4898.5 | 351.07 | 175.5 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
251 | 14613 | 4871.0 | 392.98 | 131.0 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
252 | 14598 | 4866.0 | 577.18 | 192.4 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
253 | 4849 | 4849.0 | 147.41 | 147.4 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
254 | 4846 | 4846.0 | 97.56 | 97.6 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
255 | 24162 | 4832.4 | 410.17 | 82.0 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
256 | 4828 | 4828.0 | 90.06 | 90.1 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
257 | 9651 | 4825.5 | 159.82 | 79.9 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
258 | 14447 | 4815.7 | 357.03 | 119.0 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
259 | 9619 | 4809.5 | 260.03 | 130.0 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
260 | 14396 | 4798.7 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
261 | 9596 | 4798.0 | 175.22 | 87.6 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
262 | 4788 | 4788.0 | 59.75 | 59.8 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
263 | 4781 | 4781.0 | 107.14 | 107.1 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
264 | 9554 | 4777.0 | 324.48 | 162.2 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
265 | 4766 | 4766.0 | 104.77 | 104.8 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
266 | 9516 | 4758.0 | 218.14 | 109.1 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
267 | 9504 | 4752.0 | 158.27 | 79.1 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
268 | 9425 | 4712.5 | 237.16 | 118.6 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
269 | 9402 | 4701.0 | 386.94 | 193.5 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
270 | 4700 | 4700.0 | 156.95 | 156.9 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
271 | 4691 | 4691.0 | 203.52 | 203.5 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
272 | 14059 | 4686.3 | 484.9 | 161.6 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
273 | 14058 | 4686.0 | 306.38 | 102.1 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
274 | 4674 | 4674.0 | 129.91 | 129.9 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
275 | 4673 | 4673.0 | 102.83 | 102.8 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
276 | 4672 | 4672.0 | 76.21 | 76.2 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
277 | 9342 | 4671.0 | 254.66 | 127.3 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
278 | 4653 | 4653.0 | 40.41 | 40.4 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
279 | 4641 | 4641.0 | 120.3 | 120.3 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
280 | 4641 | 4641.0 | 102.91 | 102.9 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
281 | 18545 | 4636.2 | 532.63 | 133.2 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
282 | 9267 | 4633.5 | 337.83 | 168.9 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
283 | 13894 | 4631.3 | 609.28 | 203.1 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
284 | 18469 | 4617.2 | 299.28 | 74.8 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
285 | 9143 | 4571.5 | 139.96 | 70.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
286 | 4571 | 4571.0 | 93.57 | 93.6 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
287 | 9141 | 4570.5 | 202.74 | 101.4 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
288 | 13632 | 4544.0 | 445.4 | 148.5 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
289 | 4521 | 4521.0 | 140.88 | 140.9 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
290 | 4520 | 4520.0 | 96.79 | 96.8 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
291 | 13553 | 4517.7 | 482.52 | 160.8 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
292 | 13512 | 4504.0 | 430.86 | 143.6 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
293 | 17979 | 4494.8 | 538.8 | 134.7 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
294 | 4494 | 4494.0 | 114.01 | 114.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
295 | 8985 | 4492.5 | 214.68 | 107.3 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
296 | 4487 | 4487.0 | 102.81 | 102.8 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
297 | 8953 | 4476.5 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
298 | 4476 | 4476.0 | 106.26 | 106.3 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
299 | 4475 | 4475.0 | 90.25 | 90.2 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
300 | 26751 | 4458.5 | 919.05 | 153.2 | Global cancer statistics. | Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman | CA Cancer J Clin | 2011 | 21296855 | Yes |
301 | 4437 | 4437.0 | 107.62 | 107.6 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
302 | 13306 | 4435.3 | 571.3 | 190.4 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
303 | 8865 | 4432.5 | 237.13 | 118.6 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
304 | 4406 | 4406.0 | 90.39 | 90.4 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
305 | 17587 | 4396.8 | 550.39 | 137.6 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
306 | 4388 | 4388.0 | 84.98 | 85.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
307 | 8771 | 4385.5 | 202.74 | 101.4 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
308 | 8767 | 4383.5 | 161.07 | 80.5 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
309 | 8762 | 4381.0 | 219.17 | 109.6 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
310 | 8754 | 4377.0 | 325.58 | 162.8 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
311 | 4376 | 4376.0 | 83.35 | 83.3 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
312 | 4364 | 4364.0 | 158.89 | 158.9 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
313 | 8714 | 4357.0 | 251.64 | 125.8 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
314 | 4351 | 4351.0 | 221.51 | 221.5 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
315 | 26060 | 4343.3 | 951.38 | 158.6 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
316 | 8678 | 4339.0 | 358.62 | 179.3 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
317 | 13011 | 4337.0 | 624.98 | 208.3 | Cancer statistics, 2016. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2016 | 26742998 | Yes |
318 | 4334 | 4334.0 | 111.74 | 111.7 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
319 | 8643 | 4321.5 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
320 | 4319 | 4319.0 | 101.17 | 101.2 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
321 | 4300 | 4300.0 | 128.51 | 128.5 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
322 | 12883 | 4294.3 | 746.62 | 248.9 | Cancer statistics, 2018. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2018 | 29313949 | Yes |
323 | 4293 | 4293.0 | 91.11 | 91.1 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
324 | 8581 | 4290.5 | 124.47 | 62.2 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
325 | 4284 | 4284.0 | 160.38 | 160.4 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
326 | 4272 | 4272.0 | 113.29 | 113.3 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
327 | 4270 | 4270.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B De B Weir | J Physiol | 1949 | 15394301 | Yes |
328 | 4266 | 4266.0 | 92.34 | 92.3 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
329 | 8521 | 4260.5 | 312.59 | 156.3 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
330 | 29707 | 4243.9 | 652.82 | 93.3 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
331 | 4242 | 4242.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
332 | 25417 | 4236.2 | 829.44 | 138.2 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
333 | 4236 | 4236.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
334 | 4235 | 4235.0 | 87.39 | 87.4 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
335 | 4235 | 4235.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
336 | 4235 | 4235.0 | 199.93 | 199.9 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | No |
337 | 4226 | 4226.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
338 | 4220 | 4220.0 | 109.67 | 109.7 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
339 | 4216 | 4216.0 | 93.82 | 93.8 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
340 | 4212 | 4212.0 | 91.04 | 91.0 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
341 | 4206 | 4206.0 | 75.86 | 75.9 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
342 | 12617 | 4205.7 | 467.9 | 156.0 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
343 | 4196 | 4196.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
344 | 4186 | 4186.0 | 92.75 | 92.8 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
345 | 4183 | 4183.0 | 87.0 | 87.0 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
346 | 4182 | 4182.0 | 109.11 | 109.1 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
347 | 8359 | 4179.5 | 222.69 | 111.3 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
348 | 8344 | 4172.0 | 223.42 | 111.7 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | No |
349 | 4167 | 4167.0 | 129.44 | 129.4 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
350 | 12493 | 4164.3 | 469.86 | 156.6 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
351 | 37463 | 4162.6 | 945.83 | 105.1 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin | Bioinformatics | 2009 | 19505943 | Yes |
352 | 16629 | 4157.2 | 622.3 | 155.6 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Ann Intern Med | 2009 | 19622511 | No |
353 | 4152 | 4152.0 | 50.54 | 50.5 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
354 | 4146 | 4146.0 | 152.21 | 152.2 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
355 | 4144 | 4144.0 | 173.27 | 173.3 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
356 | 8281 | 4140.5 | 177.6 | 88.8 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
357 | 4136 | 4136.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
358 | 8252 | 4126.0 | 263.2 | 131.6 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
359 | 4094 | 4094.0 | 128.32 | 128.3 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
360 | 8180 | 4090.0 | 209.21 | 104.6 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
361 | 4086 | 4086.0 | 168.97 | 169.0 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
362 | 4084 | 4084.0 | 84.77 | 84.8 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
363 | 4061 | 4061.0 | 127.63 | 127.6 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
364 | 4054 | 4054.0 | 112.83 | 112.8 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
365 | 4042 | 4042.0 | 79.12 | 79.1 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
366 | 4038 | 4038.0 | 136.09 | 136.1 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
367 | 12106 | 4035.3 | 614.49 | 204.8 | Cancer Statistics, 2017. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2017 | 28055103 | Yes |
368 | 4032 | 4032.0 | 109.53 | 109.5 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
369 | 8041 | 4020.5 | 222.75 | 111.4 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
370 | 4003 | 4003.0 | 103.49 | 103.5 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
371 | 3995 | 3995.0 | 70.08 | 70.1 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
372 | 15975 | 3993.8 | 580.73 | 145.2 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | BMJ | 2009 | 19622551 | No |
373 | 3989 | 3989.0 | 107.21 | 107.2 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
374 | 3974 | 3974.0 | 100.42 | 100.4 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
375 | 3973 | 3973.0 | 115.9 | 115.9 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
376 | 3972 | 3972.0 | 128.38 | 128.4 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
377 | 3971 | 3971.0 | 97.44 | 97.4 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
378 | 11900 | 3966.7 | 303.96 | 101.3 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
379 | 3964 | 3964.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
380 | 7923 | 3961.5 | 149.7 | 74.8 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
381 | 7912 | 3956.0 | 194.25 | 97.1 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
382 | 7865 | 3932.5 | 200.02 | 100.0 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
383 | 3931 | 3931.0 | 104.51 | 104.5 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
384 | 3926 | 3926.0 | 85.32 | 85.3 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
385 | 7846 | 3923.0 | 219.14 | 109.6 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
386 | 3920 | 3920.0 | 103.93 | 103.9 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
387 | 3916 | 3916.0 | 84.04 | 84.0 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
388 | 3911 | 3911.0 | 64.3 | 64.3 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
389 | 3907 | 3907.0 | 120.52 | 120.5 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
390 | 3907 | 3907.0 | 103.06 | 103.1 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
391 | 11713 | 3904.3 | 315.35 | 105.1 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
392 | 3889 | 3889.0 | 80.38 | 80.4 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
393 | 7773 | 3886.5 | 146.57 | 73.3 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
394 | 19429 | 3885.8 | 755.33 | 151.1 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
395 | 15539 | 3884.8 | 360.77 | 90.2 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
396 | 3883 | 3883.0 | 109.74 | 109.7 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
397 | 3878 | 3878.0 | 119.3 | 119.3 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
398 | 7756 | 3878.0 | 258.46 | 129.2 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
399 | 3856 | 3856.0 | 94.73 | 94.7 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
400 | 3852 | 3852.0 | 125.14 | 125.1 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
401 | 3848 | 3848.0 | 127.67 | 127.7 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
402 | 3847 | 3847.0 | 98.06 | 98.1 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
403 | 7676 | 3838.0 | 306.42 | 153.2 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
404 | 3831 | 3831.0 | 95.79 | 95.8 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
405 | 3830 | 3830.0 | 101.64 | 101.6 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
406 | 3828 | 3828.0 | 96.75 | 96.8 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
407 | 3818 | 3818.0 | 90.85 | 90.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
408 | 3815 | 3815.0 | 84.53 | 84.5 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
409 | 3812 | 3812.0 | 103.12 | 103.1 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
410 | 3802 | 3802.0 | 110.1 | 110.1 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
411 | 3800 | 3800.0 | 80.81 | 80.8 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
412 | 3798 | 3798.0 | 74.17 | 74.2 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
413 | 7590 | 3795.0 | 167.75 | 83.9 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
414 | 3792 | 3792.0 | 80.29 | 80.3 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
415 | 3792 | 3792.0 | 117.26 | 117.3 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
416 | 3791 | 3791.0 | 108.61 | 108.6 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
417 | 3784 | 3784.0 | 126.86 | 126.9 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
418 | 15108 | 3777.0 | 483.65 | 120.9 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
419 | 7549 | 3774.5 | 189.77 | 94.9 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
420 | 3772 | 3772.0 | 87.37 | 87.4 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
421 | 3769 | 3769.0 | 119.05 | 119.0 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
422 | 3764 | 3764.0 | 77.43 | 77.4 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | No |
423 | 7528 | 3764.0 | 209.04 | 104.5 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
424 | 7522 | 3761.0 | 181.22 | 90.6 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
425 | 3760 | 3760.0 | 108.81 | 108.8 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
426 | 3757 | 3757.0 | 154.6 | 154.6 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
427 | 3749 | 3749.0 | 89.19 | 89.2 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
428 | 7495 | 3747.5 | 180.15 | 90.1 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
429 | 3746 | 3746.0 | 107.25 | 107.2 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
430 | 11227 | 3742.3 | 215.08 | 71.7 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
431 | 3735 | 3735.0 | 169.18 | 169.2 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
432 | 14891 | 3722.8 | 383.76 | 95.9 | Global cancer statistics, 2002. | D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani | CA Cancer J Clin | 2005 | 15761078 | Yes |
433 | 3703 | 3703.0 | 61.47 | 61.5 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
434 | 3703 | 3703.0 | 93.66 | 93.7 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
435 | 7404 | 3702.0 | 253.95 | 127.0 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
436 | 3690 | 3690.0 | 66.29 | 66.3 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
437 | 3682 | 3682.0 | 106.02 | 106.0 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
438 | 3681 | 3681.0 | 88.93 | 88.9 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
439 | 7356 | 3678.0 | 184.47 | 92.2 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
440 | 3677 | 3677.0 | 85.79 | 85.8 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
441 | 3676 | 3676.0 | 103.26 | 103.3 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
442 | 7350 | 3675.0 | 161.53 | 80.8 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
443 | 3668 | 3668.0 | 103.22 | 103.2 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
444 | 3640 | 3640.0 | 100.66 | 100.7 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
445 | 3640 | 3640.0 | 94.83 | 94.8 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
446 | 7234 | 3617.0 | 183.22 | 91.6 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
447 | 21686 | 3614.3 | 973.62 | 162.3 | Global cancer statistics, 2012. | Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25651787 | Yes |
448 | 3602 | 3602.0 | 108.0 | 108.0 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
449 | 3602 | 3602.0 | 84.63 | 84.6 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
450 | 10737 | 3579.0 | 258.68 | 86.2 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
451 | 7155 | 3577.5 | 180.69 | 90.3 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
452 | 3576 | 3576.0 | 74.76 | 74.8 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
453 | 3559 | 3559.0 | 84.94 | 84.9 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
454 | 3553 | 3553.0 | 108.8 | 108.8 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
455 | 3550 | 3550.0 | 97.02 | 97.0 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
456 | 3540 | 3540.0 | 70.68 | 70.7 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
457 | 3537 | 3537.0 | 164.12 | 164.1 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
458 | 10605 | 3535.0 | 260.42 | 86.8 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
459 | 17633 | 3526.6 | 1202.77 | 240.6 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
460 | 3526 | 3526.0 | 80.0 | 80.0 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
461 | 3525 | 3525.0 | 109.37 | 109.4 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
462 | 3522 | 3522.0 | 66.7 | 66.7 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
463 | 7044 | 3522.0 | 126.91 | 63.5 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
464 | 3516 | 3516.0 | 54.17 | 54.2 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
465 | 7030 | 3515.0 | 145.06 | 72.5 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
466 | 3515 | 3515.0 | 104.9 | 104.9 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
467 | 3511 | 3511.0 | 113.04 | 113.0 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
468 | 7020 | 3510.0 | 358.29 | 179.1 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
469 | 3508 | 3508.0 | 80.02 | 80.0 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
470 | 17535 | 3507.0 | 496.08 | 99.2 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
471 | 7014 | 3507.0 | 83.26 | 41.6 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
472 | 3504 | 3504.0 | 90.91 | 90.9 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
473 | 3501 | 3501.0 | 56.74 | 56.7 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
474 | 3501 | 3501.0 | 86.49 | 86.5 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
475 | 3496 | 3496.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
476 | 3490 | 3490.0 | 128.39 | 128.4 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
477 | 3488 | 3488.0 | 58.94 | 58.9 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
478 | 3481 | 3481.0 | 84.84 | 84.8 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
479 | 3476 | 3476.0 | 51.93 | 51.9 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
480 | 3473 | 3473.0 | 80.83 | 80.8 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
481 | 10418 | 3472.7 | 392.26 | 130.8 | Cancer statistics, 2013. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2013 | 23335087 | Yes |
482 | 3469 | 3469.0 | 86.38 | 86.4 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
483 | 3457 | 3457.0 | 134.97 | 135.0 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
484 | 3455 | 3455.0 | 533.68 | 533.7 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | No |
485 | 3454 | 3454.0 | 154.88 | 154.9 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
486 | 3452 | 3452.0 | 102.48 | 102.5 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
487 | 6901 | 3450.5 | 135.58 | 67.8 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
488 | 3449 | 3449.0 | 93.77 | 93.8 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
489 | 3443 | 3443.0 | 86.84 | 86.8 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
490 | 3442 | 3442.0 | 74.6 | 74.6 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
491 | 3441 | 3441.0 | 110.3 | 110.3 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
492 | 6872 | 3436.0 | 162.63 | 81.3 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
493 | 10279 | 3426.3 | 448.36 | 149.5 | Cancer statistics, 2015. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25559415 | Yes |
494 | 3416 | 3416.0 | 59.98 | 60.0 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
495 | 6801 | 3400.5 | 172.64 | 86.3 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
496 | 3388 | 3388.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
497 | 3386 | 3386.0 | 82.53 | 82.5 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
498 | 6772 | 3386.0 | 184.93 | 92.5 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
499 | 10139 | 3379.7 | 98.26 | 32.8 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
500 | 6749 | 3374.5 | 159.63 | 79.8 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
501 | 10109 | 3369.7 | 358.86 | 119.6 | Cancer statistics, 2012. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2012 | 22237781 | Yes |
502 | 6737 | 3368.5 | 207.57 | 103.8 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
503 | 6727 | 3363.5 | 128.64 | 64.3 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
504 | 3363 | 3363.0 | 76.44 | 76.4 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
505 | 3355 | 3355.0 | 94.72 | 94.7 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
506 | 3351 | 3351.0 | 68.64 | 68.6 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
507 | 6670 | 3335.0 | 141.99 | 71.0 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
508 | 3327 | 3327.0 | 68.01 | 68.0 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
509 | 3317 | 3317.0 | 79.88 | 79.9 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
510 | 3302 | 3302.0 | 83.86 | 83.9 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
511 | 3300 | 3300.0 | 89.34 | 89.3 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
512 | 3300 | 3300.0 | 64.23 | 64.2 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
513 | 3300 | 3300.0 | 47.43 | 47.4 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
514 | 6587 | 3293.5 | 207.04 | 103.5 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
515 | 6581 | 3290.5 | 157.68 | 78.8 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
516 | 6565 | 3282.5 | 204.82 | 102.4 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
517 | 6553 | 3276.5 | 217.04 | 108.5 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman | Hepatology | 2011 | 21374666 | No |
518 | 3275 | 3275.0 | 66.82 | 66.8 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
519 | 6550 | 3275.0 | 178.29 | 89.1 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
520 | 3270 | 3270.0 | 60.05 | 60.0 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
521 | 3269 | 3269.0 | 86.96 | 87.0 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
522 | 3260 | 3260.0 | 116.74 | 116.7 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
523 | 3257 | 3257.0 | 109.86 | 109.9 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
524 | 3257 | 3257.0 | 73.66 | 73.7 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
525 | 13025 | 3256.2 | 301.22 | 75.3 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
526 | 3255 | 3255.0 | 76.35 | 76.3 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
527 | 6497 | 3248.5 | 195.68 | 97.8 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
528 | 3246 | 3246.0 | 103.89 | 103.9 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
529 | 29206 | 3245.1 | 626.76 | 69.6 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
530 | 3239 | 3239.0 | 93.58 | 93.6 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
531 | 3236 | 3236.0 | 64.02 | 64.0 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
532 | 3232 | 3232.0 | 98.1 | 98.1 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
533 | 3227 | 3227.0 | 69.39 | 69.4 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
534 | 3219 | 3219.0 | 67.57 | 67.6 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
535 | 3218 | 3218.0 | 84.33 | 84.3 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
536 | 3206 | 3206.0 | 65.3 | 65.3 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
537 | 6399 | 3199.5 | 199.59 | 99.8 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
538 | 6397 | 3198.5 | 154.0 | 77.0 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
539 | 3194 | 3194.0 | 66.22 | 66.2 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
540 | 6353 | 3176.5 | 184.91 | 92.5 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
541 | 3172 | 3172.0 | 110.02 | 110.0 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
542 | 9514 | 3171.3 | 231.36 | 77.1 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
543 | 3166 | 3166.0 | 78.37 | 78.4 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | No |
544 | 6319 | 3159.5 | 133.1 | 66.5 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
545 | 3156 | 3156.0 | 90.85 | 90.8 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
546 | 12618 | 3154.5 | 477.73 | 119.4 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
547 | 3152 | 3152.0 | 96.58 | 96.6 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow | Pediatrics | 2007 | 18055651 | Yes |
548 | 6290 | 3145.0 | 206.49 | 103.2 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
549 | 3145 | 3145.0 | 78.39 | 78.4 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
550 | 3145 | 3145.0 | 84.61 | 84.6 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
551 | 6285 | 3142.5 | 54.06 | 27.0 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
552 | 9422 | 3140.7 | 266.14 | 88.7 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
553 | 6279 | 3139.5 | 152.45 | 76.2 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
554 | 6279 | 3139.5 | 101.92 | 51.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
555 | 3139 | 3139.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
556 | 3138 | 3138.0 | 74.07 | 74.1 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
557 | 12545 | 3136.2 | 456.58 | 114.1 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
558 | 3135 | 3135.0 | 121.66 | 121.7 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
559 | 3135 | 3135.0 | 26.79 | 26.8 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
560 | 3133 | 3133.0 | 65.65 | 65.7 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
561 | 3128 | 3128.0 | 65.88 | 65.9 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
562 | 3117 | 3117.0 | 89.76 | 89.8 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
563 | 6232 | 3116.0 | 163.67 | 81.8 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
564 | 9339 | 3113.0 | 194.22 | 64.7 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
565 | 6220 | 3110.0 | 156.68 | 78.3 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
566 | 3106 | 3106.0 | 115.69 | 115.7 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
567 | 6207 | 3103.5 | 266.62 | 133.3 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
568 | 3103 | 3103.0 | 124.9 | 124.9 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
569 | 3100 | 3100.0 | 76.02 | 76.0 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
570 | 6192 | 3096.0 | 196.0 | 98.0 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
571 | 3095 | 3095.0 | 88.92 | 88.9 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
572 | 9280 | 3093.3 | 311.43 | 103.8 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
573 | 21653 | 3093.3 | 802.99 | 114.7 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
574 | 3091 | 3091.0 | 89.37 | 89.4 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
575 | 3089 | 3089.0 | 106.03 | 106.0 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
576 | 6164 | 3082.0 | 108.53 | 54.3 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
577 | 3082 | 3082.0 | 72.66 | 72.7 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
578 | 6164 | 3082.0 | 136.36 | 68.2 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
579 | 6149 | 3074.5 | 180.5 | 90.2 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
580 | 27631 | 3070.1 | 872.37 | 96.9 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
581 | 3069 | 3069.0 | 85.82 | 85.8 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
582 | 6125 | 3062.5 | 188.3 | 94.2 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
583 | 3058 | 3058.0 | 65.13 | 65.1 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | No |
584 | 24430 | 3053.8 | 527.54 | 65.9 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
585 | 3051 | 3051.0 | 103.01 | 103.0 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
586 | 3049 | 3049.0 | 56.81 | 56.8 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
587 | 3042 | 3042.0 | 70.49 | 70.5 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
588 | 3042 | 3042.0 | 48.81 | 48.8 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
589 | 6072 | 3036.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
590 | 3035 | 3035.0 | 136.63 | 136.6 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
591 | 3031 | 3031.0 | 72.64 | 72.6 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
592 | 6052 | 3026.0 | 224.82 | 112.4 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
593 | 3025 | 3025.0 | 102.73 | 102.7 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
594 | 6046 | 3023.0 | 143.21 | 71.6 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
595 | 9059 | 3019.7 | 170.67 | 56.9 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
596 | 12068 | 3017.0 | 284.48 | 71.1 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
597 | 9023 | 3007.7 | 176.93 | 59.0 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
598 | 33083 | 3007.5 | 688.41 | 62.6 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
599 | 3007 | 3007.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
600 | 8988 | 2996.0 | 206.45 | 68.8 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
601 | 11970 | 2992.5 | 527.63 | 131.9 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
602 | 5983 | 2991.5 | 134.8 | 67.4 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
603 | 2984 | 2984.0 | 58.92 | 58.9 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
604 | 2982 | 2982.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta radiol | 1953 | 13057644 | Yes |
605 | 2980 | 2980.0 | 90.38 | 90.4 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
606 | 2978 | 2978.0 | 54.77 | 54.8 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
607 | 2977 | 2977.0 | 73.48 | 73.5 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
608 | 2975 | 2975.0 | 68.81 | 68.8 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
609 | 2975 | 2975.0 | 70.01 | 70.0 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
610 | 8920 | 2973.3 | 289.73 | 96.6 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
611 | 2973 | 2973.0 | 52.91 | 52.9 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
612 | 5943 | 2971.5 | 124.88 | 62.4 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
613 | 2967 | 2967.0 | 94.39 | 94.4 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
614 | 5930 | 2965.0 | 125.23 | 62.6 | Emergence of scaling in random networks. | AL Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
615 | 8889 | 2963.0 | 447.65 | 149.2 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
616 | 5924 | 2962.0 | 153.21 | 76.6 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
617 | 2961 | 2961.0 | 91.34 | 91.3 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
618 | 2955 | 2955.0 | 66.39 | 66.4 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
619 | 8829 | 2943.0 | 241.95 | 80.6 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
620 | 5880 | 2940.0 | 184.63 | 92.3 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
621 | 2937 | 2937.0 | 66.07 | 66.1 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
622 | 2935 | 2935.0 | 102.62 | 102.6 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
623 | 5869 | 2934.5 | 236.64 | 118.3 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
624 | 8784 | 2928.0 | 202.52 | 67.5 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
625 | 2920 | 2920.0 | 47.3 | 47.3 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
626 | 5839 | 2919.5 | 122.06 | 61.0 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
627 | 11666 | 2916.5 | 342.33 | 85.6 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
628 | 2916 | 2916.0 | 43.91 | 43.9 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
629 | 2911 | 2911.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
630 | 2908 | 2908.0 | 68.69 | 68.7 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
631 | 5816 | 2908.0 | 153.42 | 76.7 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
632 | 2901 | 2901.0 | 29.31 | 29.3 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
633 | 8693 | 2897.7 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
634 | 2897 | 2897.0 | 70.64 | 70.6 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
635 | 5790 | 2895.0 | 161.84 | 80.9 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
636 | 2894 | 2894.0 | 122.3 | 122.3 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
637 | 2892 | 2892.0 | 61.89 | 61.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
638 | 5779 | 2889.5 | 177.9 | 89.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
639 | 2889 | 2889.0 | 67.33 | 67.3 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
640 | 2887 | 2887.0 | 107.1 | 107.1 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
641 | 2886 | 2886.0 | 59.69 | 59.7 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
642 | 2880 | 2880.0 | 85.97 | 86.0 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
643 | 5754 | 2877.0 | 126.61 | 63.3 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
644 | 2872 | 2872.0 | 50.46 | 50.5 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
645 | 2866 | 2866.0 | 50.74 | 50.7 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
646 | 2863 | 2863.0 | 56.52 | 56.5 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
647 | 2863 | 2863.0 | 55.75 | 55.8 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
648 | 2861 | 2861.0 | 56.1 | 56.1 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
649 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
650 | 2860 | 2860.0 | 95.51 | 95.5 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
651 | 2858 | 2858.0 | 52.34 | 52.3 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
652 | 2858 | 2858.0 | 63.71 | 63.7 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
653 | 11432 | 2858.0 | 1328.6 | 332.1 | Cancer Statistics, 2021. | Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal | CA Cancer J Clin | 2021 | 33433946 | Yes |
654 | 2856 | 2856.0 | 71.99 | 72.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
655 | 2856 | 2856.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
656 | 5710 | 2855.0 | 248.25 | 124.1 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
657 | 2852 | 2852.0 | 153.63 | 153.6 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
658 | 2850 | 2850.0 | 61.03 | 61.0 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
659 | 8546 | 2848.7 | 246.9 | 82.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
660 | 2836 | 2836.0 | 93.76 | 93.8 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
661 | 2836 | 2836.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
662 | 8487 | 2829.0 | 364.41 | 121.5 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
663 | 5658 | 2829.0 | 268.82 | 134.4 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
664 | 2828 | 2828.0 | 85.62 | 85.6 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
665 | 2828 | 2828.0 | 82.21 | 82.2 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
666 | 5644 | 2822.0 | 143.44 | 71.7 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
667 | 2822 | 2822.0 | 66.59 | 66.6 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
668 | 8464 | 2821.3 | 207.07 | 69.0 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
669 | 2819 | 2819.0 | 53.7 | 53.7 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
670 | 8450 | 2816.7 | 247.48 | 82.5 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
671 | 5629 | 2814.5 | 173.58 | 86.8 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
672 | 2814 | 2814.0 | 121.4 | 121.4 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
673 | 2809 | 2809.0 | 126.47 | 126.5 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
674 | 5618 | 2809.0 | 112.9 | 56.5 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
675 | 2809 | 2809.0 | 78.74 | 78.7 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
676 | 5611 | 2805.5 | 192.93 | 96.5 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
677 | 2805 | 2805.0 | 47.64 | 47.6 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
678 | 2803 | 2803.0 | 90.33 | 90.3 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
679 | 5600 | 2800.0 | 134.69 | 67.3 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
680 | 5600 | 2800.0 | 152.53 | 76.3 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
681 | 5586 | 2793.0 | 126.6 | 63.3 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
682 | 8379 | 2793.0 | 190.21 | 63.4 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
683 | 5584 | 2792.0 | 185.45 | 92.7 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
684 | 2791 | 2791.0 | 70.02 | 70.0 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
685 | 5579 | 2789.5 | 77.86 | 38.9 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
686 | 2789 | 2789.0 | 70.54 | 70.5 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
687 | 8365 | 2788.3 | 281.37 | 93.8 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
688 | 5575 | 2787.5 | 109.97 | 55.0 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
689 | 2787 | 2787.0 | 69.83 | 69.8 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
690 | 11134 | 2783.5 | 295.56 | 73.9 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
691 | 2780 | 2780.0 | 65.08 | 65.1 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
692 | 2780 | 2780.0 | 112.34 | 112.3 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
693 | 2778 | 2778.0 | 109.18 | 109.2 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
694 | 2776 | 2776.0 | 80.44 | 80.4 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
695 | 5545 | 2772.5 | 199.91 | 100.0 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
696 | 2772 | 2772.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
697 | 11084 | 2771.0 | 335.43 | 83.9 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
698 | 5529 | 2764.5 | 152.54 | 76.3 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
699 | 5527 | 2763.5 | 130.41 | 65.2 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
700 | 5519 | 2759.5 | 161.24 | 80.6 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
701 | 5517 | 2758.5 | 127.65 | 63.8 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
702 | 5515 | 2757.5 | 133.69 | 66.8 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
703 | 2757 | 2757.0 | 82.78 | 82.8 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
704 | 5502 | 2751.0 | 91.18 | 45.6 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
705 | 5496 | 2748.0 | 185.96 | 93.0 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
706 | 2746 | 2746.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
707 | 2744 | 2744.0 | 66.03 | 66.0 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
708 | 2742 | 2742.0 | 72.57 | 72.6 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
709 | 2738 | 2738.0 | 70.51 | 70.5 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
710 | 2738 | 2738.0 | 58.94 | 58.9 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
711 | 2736 | 2736.0 | 61.67 | 61.7 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
712 | 5470 | 2735.0 | 166.83 | 83.4 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
713 | 2733 | 2733.0 | 53.01 | 53.0 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
714 | 5444 | 2722.0 | 107.52 | 53.8 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
715 | 8142 | 2714.0 | 175.36 | 58.5 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
716 | 2707 | 2707.0 | 85.22 | 85.2 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
717 | 2705 | 2705.0 | 60.93 | 60.9 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
718 | 2704 | 2704.0 | 62.56 | 62.6 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
719 | 16216 | 2702.7 | 361.26 | 60.2 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
720 | 5402 | 2701.0 | 185.12 | 92.6 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
721 | 2699 | 2699.0 | 65.1 | 65.1 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
722 | 5394 | 2697.0 | 158.56 | 79.3 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
723 | 10778 | 2694.5 | 316.97 | 79.2 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
724 | 2687 | 2687.0 | 59.5 | 59.5 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
725 | 8058 | 2686.0 | 199.31 | 66.4 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
726 | 2686 | 2686.0 | 104.66 | 104.7 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
727 | 2685 | 2685.0 | 23.47 | 23.5 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
728 | 10734 | 2683.5 | 227.44 | 56.9 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
729 | 2682 | 2682.0 | 60.23 | 60.2 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
730 | 2682 | 2682.0 | 82.68 | 82.7 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
731 | 5357 | 2678.5 | 164.66 | 82.3 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
732 | 2675 | 2675.0 | 51.47 | 51.5 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
733 | 2663 | 2663.0 | 60.82 | 60.8 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
734 | 5325 | 2662.5 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
735 | 2660 | 2660.0 | 62.1 | 62.1 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
736 | 5319 | 2659.5 | 165.13 | 82.6 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
737 | 2658 | 2658.0 | 83.31 | 83.3 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
738 | 2646 | 2646.0 | 59.5 | 59.5 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
739 | 5286 | 2643.0 | 210.36 | 105.2 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
740 | 2641 | 2641.0 | 82.05 | 82.0 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
741 | 2638 | 2638.0 | 107.04 | 107.0 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
742 | 2636 | 2636.0 | 75.45 | 75.5 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
743 | 2632 | 2632.0 | 90.38 | 90.4 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
744 | 5260 | 2630.0 | 107.91 | 54.0 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
745 | 2624 | 2624.0 | 98.28 | 98.3 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
746 | 2623 | 2623.0 | 105.93 | 105.9 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
747 | 2623 | 2623.0 | 65.26 | 65.3 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
748 | 7859 | 2619.7 | 204.94 | 68.3 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
749 | 5237 | 2618.5 | 136.9 | 68.5 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
750 | 5236 | 2618.0 | 101.8 | 50.9 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
751 | 2617 | 2617.0 | 132.27 | 132.3 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
752 | 5224 | 2612.0 | 117.36 | 58.7 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
753 | 2612 | 2612.0 | 122.43 | 122.4 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
754 | 5222 | 2611.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
755 | 2609 | 2609.0 | 72.47 | 72.5 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
756 | 5216 | 2608.0 | 103.04 | 51.5 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
757 | 5213 | 2606.5 | 180.61 | 90.3 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
758 | 2606 | 2606.0 | 72.76 | 72.8 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
759 | 2600 | 2600.0 | 50.74 | 50.7 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
760 | 2599 | 2599.0 | 56.53 | 56.5 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
761 | 2592 | 2592.0 | 73.32 | 73.3 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
762 | 5179 | 2589.5 | 73.53 | 36.8 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
763 | 2588 | 2588.0 | 127.2 | 127.2 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
764 | 2587 | 2587.0 | 55.33 | 55.3 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
765 | 2586 | 2586.0 | 53.65 | 53.6 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
766 | 2585 | 2585.0 | 52.56 | 52.6 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
767 | 5169 | 2584.5 | 167.78 | 83.9 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
768 | 5167 | 2583.5 | 127.31 | 63.7 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
769 | 2582 | 2582.0 | 61.62 | 61.6 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
770 | 2579 | 2579.0 | 80.62 | 80.6 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
771 | 2577 | 2577.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
772 | 5151 | 2575.5 | 160.21 | 80.1 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
773 | 2575 | 2575.0 | 71.18 | 71.2 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
774 | 2572 | 2572.0 | 68.83 | 68.8 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
775 | 2572 | 2572.0 | 73.33 | 73.3 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
776 | 2568 | 2568.0 | 61.84 | 61.8 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
777 | 2561 | 2561.0 | 79.26 | 79.3 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
778 | 2560 | 2560.0 | 36.04 | 36.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
779 | 5112 | 2556.0 | 158.96 | 79.5 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
780 | 2555 | 2555.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
781 | 2546 | 2546.0 | 83.04 | 83.0 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
782 | 2545 | 2545.0 | 67.13 | 67.1 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
783 | 2545 | 2545.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
784 | 5089 | 2544.5 | 223.98 | 112.0 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
785 | 2543 | 2543.0 | 54.92 | 54.9 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
786 | 10138 | 2534.5 | 1929.31 | 482.3 | Cancer statistics, 2022. | Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal | CA Cancer J Clin | 2022 | 35020204 | Yes |
787 | 5068 | 2534.0 | 275.93 | 138.0 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
788 | 2533 | 2533.0 | 51.09 | 51.1 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
789 | 2533 | 2533.0 | 61.85 | 61.9 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
790 | 5061 | 2530.5 | 116.28 | 58.1 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
791 | 2530 | 2530.0 | 28.17 | 28.2 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
792 | 7590 | 2530.0 | 199.04 | 66.3 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
793 | 2523 | 2523.0 | 74.1 | 74.1 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
794 | 2513 | 2513.0 | 77.17 | 77.2 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
795 | 7535 | 2511.7 | 204.34 | 68.1 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
796 | 7534 | 2511.3 | 187.3 | 62.4 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
797 | 2509 | 2509.0 | 54.97 | 55.0 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
798 | 5012 | 2506.0 | 129.56 | 64.8 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
799 | 10021 | 2505.2 | 400.88 | 100.2 | Cancer statistics, 2014. | Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal | CA Cancer J Clin | 2014 | 24399786 | Yes |
800 | 5010 | 2505.0 | 100.25 | 50.1 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
801 | 2503 | 2503.0 | 44.91 | 44.9 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
802 | 2503 | 2503.0 | 62.01 | 62.0 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
803 | 7498 | 2499.3 | 215.44 | 71.8 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hänzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
804 | 7487 | 2495.7 | 193.65 | 64.5 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
805 | 4983 | 2491.5 | 181.26 | 90.6 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
806 | 4982 | 2491.0 | 147.89 | 73.9 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
807 | 4979 | 2489.5 | 141.46 | 70.7 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
808 | 4974 | 2487.0 | 123.38 | 61.7 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
809 | 9936 | 2484.0 | 510.68 | 127.7 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
810 | 4966 | 2483.0 | 119.73 | 59.9 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
811 | 4956 | 2478.0 | 96.24 | 48.1 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
812 | 2472 | 2472.0 | 111.94 | 111.9 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
813 | 2470 | 2470.0 | 46.96 | 47.0 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
814 | 2470 | 2470.0 | 92.19 | 92.2 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
815 | 2466 | 2466.0 | 61.91 | 61.9 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
816 | 2461 | 2461.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
817 | 4916 | 2458.0 | 130.77 | 65.4 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
818 | 4915 | 2457.5 | 142.01 | 71.0 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
819 | 2456 | 2456.0 | 53.51 | 53.5 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
820 | 7348 | 2449.3 | 209.14 | 69.7 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
821 | 2445 | 2445.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
822 | 4890 | 2445.0 | 103.7 | 51.9 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
823 | 4887 | 2443.5 | 108.42 | 54.2 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
824 | 2442 | 2442.0 | 47.28 | 47.3 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
825 | 2441 | 2441.0 | 78.25 | 78.2 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
826 | 2441 | 2441.0 | 57.87 | 57.9 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
827 | 2441 | 2441.0 | 110.58 | 110.6 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
828 | 2439 | 2439.0 | 65.5 | 65.5 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
829 | 2438 | 2438.0 | 54.09 | 54.1 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
830 | 2438 | 2438.0 | 58.52 | 58.5 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
831 | 9743 | 2435.8 | 253.42 | 63.4 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
832 | 2434 | 2434.0 | 82.31 | 82.3 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
833 | 4863 | 2431.5 | 68.87 | 34.4 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
834 | 2431 | 2431.0 | 130.74 | 130.7 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
835 | 2430 | 2430.0 | 61.36 | 61.4 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
836 | 4859 | 2429.5 | 120.91 | 60.5 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
837 | 9709 | 2427.2 | 231.95 | 58.0 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
838 | 2422 | 2422.0 | 53.88 | 53.9 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
839 | 2421 | 2421.0 | 80.39 | 80.4 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
840 | 4837 | 2418.5 | 157.5 | 78.8 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
841 | 4837 | 2418.5 | 142.58 | 71.3 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
842 | 4833 | 2416.5 | 115.31 | 57.7 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
843 | 2413 | 2413.0 | 52.62 | 52.6 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
844 | 2411 | 2411.0 | 50.36 | 50.4 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
845 | 4821 | 2410.5 | 92.8 | 46.4 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
846 | 2408 | 2408.0 | 43.83 | 43.8 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
847 | 4815 | 2407.5 | 163.86 | 81.9 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
848 | 2406 | 2406.0 | 75.67 | 75.7 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
849 | 4805 | 2402.5 | 143.14 | 71.6 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
850 | 2399 | 2399.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
851 | 4796 | 2398.0 | 93.97 | 47.0 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
852 | 2396 | 2396.0 | 63.95 | 64.0 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
853 | 4777 | 2388.5 | 128.72 | 64.4 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
854 | 2388 | 2388.0 | 72.48 | 72.5 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
855 | 2388 | 2388.0 | 93.26 | 93.3 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
856 | 2388 | 2388.0 | 43.31 | 43.3 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
857 | 2386 | 2386.0 | 54.51 | 54.5 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
858 | 4772 | 2386.0 | 133.98 | 67.0 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
859 | 4770 | 2385.0 | 120.29 | 60.1 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman | Hepatology | 2005 | 16250051 | No |
860 | 2382 | 2382.0 | 97.97 | 98.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
861 | 4764 | 2382.0 | 207.0 | 103.5 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
862 | 2378 | 2378.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
863 | 2373 | 2373.0 | 51.47 | 51.5 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
864 | 2370 | 2370.0 | 49.28 | 49.3 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
865 | 2369 | 2369.0 | 62.25 | 62.2 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
866 | 7106 | 2368.7 | 154.16 | 51.4 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
867 | 2365 | 2365.0 | 79.41 | 79.4 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
868 | 2362 | 2362.0 | 97.79 | 97.8 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
869 | 2359 | 2359.0 | 56.58 | 56.6 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
870 | 2357 | 2357.0 | 152.64 | 152.6 | Obesity: global epidemiology and pathogenesis. | Matthias Blüher | Nat Rev Endocrinol | 2019 | 30814686 | No |
871 | 2356 | 2356.0 | 51.61 | 51.6 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
872 | 4711 | 2355.5 | 97.44 | 48.7 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
873 | 4703 | 2351.5 | 103.17 | 51.6 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
874 | 7049 | 2349.7 | 69.93 | 23.3 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
875 | 2348 | 2348.0 | 66.64 | 66.6 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
876 | 4695 | 2347.5 | 118.81 | 59.4 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
877 | 4695 | 2347.5 | 127.56 | 63.8 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
878 | 2347 | 2347.0 | 60.38 | 60.4 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
879 | 2346 | 2346.0 | 111.73 | 111.7 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
880 | 4691 | 2345.5 | 117.74 | 58.9 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
881 | 2344 | 2344.0 | 103.73 | 103.7 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
882 | 2344 | 2344.0 | 57.0 | 57.0 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
883 | 4681 | 2340.5 | 103.18 | 51.6 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
884 | 2338 | 2338.0 | 59.07 | 59.1 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
885 | 4675 | 2337.5 | 171.4 | 85.7 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
886 | 2337 | 2337.0 | 52.01 | 52.0 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
887 | 2337 | 2337.0 | 59.47 | 59.5 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
888 | 4672 | 2336.0 | 102.98 | 51.5 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
889 | 4669 | 2334.5 | 341.39 | 170.7 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | No |
890 | 4662 | 2331.0 | 87.78 | 43.9 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
891 | 4657 | 2328.5 | 122.62 | 61.3 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
892 | 2327 | 2327.0 | 77.71 | 77.7 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
893 | 2325 | 2325.0 | 84.24 | 84.2 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
894 | 2324 | 2324.0 | 66.15 | 66.2 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
895 | 2324 | 2324.0 | 57.13 | 57.1 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
896 | 2323 | 2323.0 | 41.96 | 42.0 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
897 | 2322 | 2322.0 | 55.43 | 55.4 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
898 | 2321 | 2321.0 | 57.39 | 57.4 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
899 | 4642 | 2321.0 | 113.4 | 56.7 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
900 | 2320 | 2320.0 | 78.35 | 78.3 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
901 | 4640 | 2320.0 | 124.01 | 62.0 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
902 | 2320 | 2320.0 | 65.32 | 65.3 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
903 | 4638 | 2319.0 | 129.89 | 64.9 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
904 | 2319 | 2319.0 | 50.01 | 50.0 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
905 | 4638 | 2319.0 | 89.75 | 44.9 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | No |
906 | 2318 | 2318.0 | 75.5 | 75.5 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
907 | 2318 | 2318.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
908 | 2317 | 2317.0 | 48.82 | 48.8 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
909 | 2317 | 2317.0 | 135.49 | 135.5 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | No |
910 | 2313 | 2313.0 | 79.42 | 79.4 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
911 | 9246 | 2311.5 | 201.52 | 50.4 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
912 | 2309 | 2309.0 | 53.46 | 53.5 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
913 | 2309 | 2309.0 | 55.82 | 55.8 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
914 | 2309 | 2309.0 | 27.38 | 27.4 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
915 | 4615 | 2307.5 | 76.18 | 38.1 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
916 | 2306 | 2306.0 | 58.9 | 58.9 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
917 | 2305 | 2305.0 | 65.48 | 65.5 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
918 | 4602 | 2301.0 | 72.03 | 36.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
919 | 4600 | 2300.0 | 168.76 | 84.4 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
920 | 4599 | 2299.5 | 123.62 | 61.8 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
921 | 2298 | 2298.0 | 56.98 | 57.0 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
922 | 2298 | 2298.0 | 71.78 | 71.8 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
923 | 4586 | 2293.0 | 86.58 | 43.3 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
924 | 4584 | 2292.0 | 115.23 | 57.6 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
925 | 4580 | 2290.0 | 107.01 | 53.5 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
926 | 2289 | 2289.0 | 60.19 | 60.2 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
927 | 2288 | 2288.0 | 95.03 | 95.0 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
928 | 2287 | 2287.0 | 72.73 | 72.7 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
929 | 2286 | 2286.0 | 105.17 | 105.2 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
930 | 2282 | 2282.0 | 74.48 | 74.5 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
931 | 2282 | 2282.0 | 55.71 | 55.7 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
932 | 2281 | 2281.0 | 71.19 | 71.2 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
933 | 2281 | 2281.0 | 45.28 | 45.3 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
934 | 2278 | 2278.0 | 42.72 | 42.7 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
935 | 2277 | 2277.0 | 60.02 | 60.0 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
936 | 2276 | 2276.0 | 76.25 | 76.2 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
937 | 4551 | 2275.5 | 94.81 | 47.4 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
938 | 2275 | 2275.0 | 59.72 | 59.7 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
939 | 13645 | 2274.2 | 724.57 | 120.8 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
940 | 2272 | 2272.0 | 65.76 | 65.8 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | No |
941 | 4543 | 2271.5 | 129.53 | 64.8 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
942 | 4541 | 2270.5 | 101.37 | 50.7 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
943 | 2264 | 2264.0 | 65.77 | 65.8 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
944 | 4528 | 2264.0 | 552.22 | 276.1 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
945 | 2263 | 2263.0 | 48.85 | 48.9 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
946 | 2263 | 2263.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
947 | 2262 | 2262.0 | 67.36 | 67.4 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
948 | 2260 | 2260.0 | 50.97 | 51.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
949 | 2260 | 2260.0 | 58.5 | 58.5 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
950 | 2259 | 2259.0 | 44.34 | 44.3 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
951 | 4518 | 2259.0 | 115.83 | 57.9 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
952 | 2258 | 2258.0 | 116.43 | 116.4 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
953 | 2254 | 2254.0 | 68.7 | 68.7 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
954 | 2251 | 2251.0 | 136.43 | 136.4 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
955 | 2251 | 2251.0 | 56.03 | 56.0 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
956 | 4495 | 2247.5 | 102.86 | 51.4 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
957 | 8988 | 2247.0 | 181.78 | 45.4 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
958 | 2246 | 2246.0 | 83.93 | 83.9 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
959 | 2245 | 2245.0 | 53.13 | 53.1 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
960 | 2244 | 2244.0 | 70.54 | 70.5 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
961 | 2243 | 2243.0 | 61.33 | 61.3 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
962 | 4485 | 2242.5 | 108.26 | 54.1 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
963 | 4480 | 2240.0 | 114.05 | 57.0 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
964 | 2240 | 2240.0 | 57.24 | 57.2 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
965 | 4474 | 2237.0 | 88.63 | 44.3 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
966 | 2237 | 2237.0 | 54.85 | 54.9 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
967 | 2236 | 2236.0 | 41.73 | 41.7 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | No |
968 | 4471 | 2235.5 | 88.06 | 44.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
969 | 2235 | 2235.0 | 110.13 | 110.1 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
970 | 4470 | 2235.0 | 39.27 | 19.6 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
971 | 17863 | 2232.9 | 561.68 | 70.2 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
972 | 2232 | 2232.0 | 77.21 | 77.2 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
973 | 4463 | 2231.5 | 128.87 | 64.4 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
974 | 2231 | 2231.0 | 60.14 | 60.1 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
975 | 2224 | 2224.0 | 48.99 | 49.0 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
976 | 2224 | 2224.0 | 68.5 | 68.5 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
977 | 4447 | 2223.5 | 98.24 | 49.1 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
978 | 19998 | 2222.0 | 915.49 | 101.7 | Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. | Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray | Int J Cancer | 2015 | 25220842 | Yes |
979 | 2221 | 2221.0 | 52.48 | 52.5 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
980 | 6658 | 2219.3 | 257.41 | 85.8 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
981 | 6652 | 2217.3 | 183.77 | 61.3 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
982 | 2213 | 2213.0 | 89.61 | 89.6 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
983 | 2212 | 2212.0 | 49.29 | 49.3 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
984 | 2211 | 2211.0 | 87.44 | 87.4 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
985 | 2210 | 2210.0 | 71.94 | 71.9 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
986 | 2209 | 2209.0 | 65.49 | 65.5 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
987 | 2208 | 2208.0 | 61.97 | 62.0 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
988 | 4415 | 2207.5 | 99.0 | 49.5 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
989 | 8830 | 2207.5 | 189.01 | 47.3 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
990 | 2205 | 2205.0 | 83.72 | 83.7 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
991 | 2205 | 2205.0 | 63.22 | 63.2 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
992 | 2204 | 2204.0 | 61.47 | 61.5 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
993 | 2200 | 2200.0 | 54.63 | 54.6 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
994 | 2200 | 2200.0 | 87.88 | 87.9 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
995 | 2199 | 2199.0 | 56.8 | 56.8 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
996 | 2197 | 2197.0 | 46.87 | 46.9 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
997 | 4393 | 2196.5 | 95.62 | 47.8 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
998 | 2196 | 2196.0 | 68.08 | 68.1 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
999 | 6587 | 2195.7 | 194.87 | 65.0 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
1000 | 4388 | 2194.0 | 148.5 | 74.2 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
1001 | 2193 | 2193.0 | 48.62 | 48.6 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
1002 | 2193 | 2193.0 | 70.49 | 70.5 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
1003 | 2192 | 2192.0 | 79.07 | 79.1 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
1004 | 2191 | 2191.0 | 53.83 | 53.8 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
1005 | 4380 | 2190.0 | 105.32 | 52.7 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
1006 | 4378 | 2189.0 | 76.37 | 38.2 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
1007 | 2189 | 2189.0 | 56.05 | 56.0 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
1008 | 6562 | 2187.3 | 204.83 | 68.3 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
1009 | 2186 | 2186.0 | 52.71 | 52.7 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral | Lancet | 2003 | 12927427 | Yes |
1010 | 2184 | 2184.0 | 66.37 | 66.4 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
1011 | 2183 | 2183.0 | 79.23 | 79.2 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
1012 | 4365 | 2182.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
1013 | 2181 | 2181.0 | 90.68 | 90.7 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
1014 | 2181 | 2181.0 | 58.85 | 58.9 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
1015 | 8718 | 2179.5 | 209.24 | 52.3 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
1016 | 8716 | 2179.0 | 549.04 | 137.3 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
1017 | 4357 | 2178.5 | 103.46 | 51.7 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
1018 | 2176 | 2176.0 | 65.94 | 65.9 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
1019 | 2175 | 2175.0 | 48.38 | 48.4 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
1020 | 2172 | 2172.0 | 56.56 | 56.6 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
1021 | 2166 | 2166.0 | 60.18 | 60.2 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
1022 | 2166 | 2166.0 | 55.07 | 55.1 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
1023 | 34653 | 2165.8 | 1111.71 | 69.5 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
1024 | 4325 | 2162.5 | 147.76 | 73.9 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
1025 | 6486 | 2162.0 | 197.27 | 65.8 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
1026 | 4317 | 2158.5 | 182.15 | 91.1 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
1027 | 2158 | 2158.0 | 71.04 | 71.0 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
1028 | 2158 | 2158.0 | 41.74 | 41.7 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
1029 | 2154 | 2154.0 | 93.17 | 93.2 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
1030 | 2152 | 2152.0 | 49.15 | 49.1 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
1031 | 2152 | 2152.0 | 31.2 | 31.2 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
1032 | 6454 | 2151.3 | 186.31 | 62.1 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
1033 | 2151 | 2151.0 | 45.8 | 45.8 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | No |
1034 | 4302 | 2151.0 | 111.57 | 55.8 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
1035 | 12905 | 2150.8 | 287.93 | 48.0 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
1036 | 2150 | 2150.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
1037 | 4300 | 2150.0 | 150.14 | 75.1 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
1038 | 2149 | 2149.0 | 49.59 | 49.6 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
1039 | 2149 | 2149.0 | 39.98 | 40.0 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
1040 | 2148 | 2148.0 | 51.57 | 51.6 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
1041 | 2145 | 2145.0 | 48.71 | 48.7 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
1042 | 6434 | 2144.7 | 131.58 | 43.9 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
1043 | 4288 | 2144.0 | 117.09 | 58.5 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
1044 | 2143 | 2143.0 | 115.66 | 115.7 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
1045 | 6425 | 2141.7 | 281.26 | 93.8 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
1046 | 4282 | 2141.0 | 100.46 | 50.2 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
1047 | 4281 | 2140.5 | 83.41 | 41.7 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
1048 | 2140 | 2140.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
1049 | 4278 | 2139.0 | 73.25 | 36.6 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
1050 | 4275 | 2137.5 | 103.49 | 51.7 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
1051 | 4274 | 2137.0 | 106.96 | 53.5 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
1052 | 4273 | 2136.5 | 80.43 | 40.2 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
1053 | 6404 | 2134.7 | 131.25 | 43.8 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
1054 | 2134 | 2134.0 | 64.71 | 64.7 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
1055 | 6400 | 2133.3 | 149.87 | 50.0 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
1056 | 2131 | 2131.0 | 49.47 | 49.5 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
1057 | 2129 | 2129.0 | 59.04 | 59.0 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
1058 | 6386 | 2128.7 | 146.26 | 48.8 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
1059 | 4256 | 2128.0 | 122.51 | 61.3 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
1060 | 4256 | 2128.0 | 127.75 | 63.9 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
1061 | 6381 | 2127.0 | 161.39 | 53.8 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
1062 | 2127 | 2127.0 | 42.12 | 42.1 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
1063 | 4253 | 2126.5 | 135.03 | 67.5 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
1064 | 4240 | 2120.0 | 82.66 | 41.3 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
1065 | 6357 | 2119.0 | 270.65 | 90.2 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
1066 | 2117 | 2117.0 | 63.98 | 64.0 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
1067 | 4228 | 2114.0 | 121.42 | 60.7 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
1068 | 2113 | 2113.0 | 35.26 | 35.3 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
1069 | 2112 | 2112.0 | 50.93 | 50.9 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
1070 | 6332 | 2110.7 | 117.72 | 39.2 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
1071 | 4220 | 2110.0 | 178.94 | 89.5 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
1072 | 2110 | 2110.0 | 44.44 | 44.4 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
1073 | 4215 | 2107.5 | 106.83 | 53.4 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
1074 | 2105 | 2105.0 | 74.77 | 74.8 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
1075 | 2104 | 2104.0 | 38.08 | 38.1 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
1076 | 2104 | 2104.0 | 47.51 | 47.5 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
1077 | 6310 | 2103.3 | 267.48 | 89.2 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
1078 | 2102 | 2102.0 | 60.63 | 60.6 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
1079 | 2100 | 2100.0 | 52.4 | 52.4 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
1080 | 2098 | 2098.0 | 42.47 | 42.5 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
1081 | 2096 | 2096.0 | 49.36 | 49.4 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
1082 | 2096 | 2096.0 | 83.6 | 83.6 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
1083 | 2093 | 2093.0 | 94.11 | 94.1 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
1084 | 4182 | 2091.0 | 120.64 | 60.3 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
1085 | 8353 | 2088.2 | 397.87 | 99.5 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
1086 | 2088 | 2088.0 | 42.53 | 42.5 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
1087 | 2087 | 2087.0 | 45.36 | 45.4 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
1088 | 8347 | 2086.8 | 303.62 | 75.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | J Clin Epidemiol | 2009 | 19631508 | No |
1089 | 6258 | 2086.0 | 185.86 | 62.0 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
1090 | 4167 | 2083.5 | 109.07 | 54.5 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
1091 | 4164 | 2082.0 | 100.63 | 50.3 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
1092 | 4162 | 2081.0 | 185.79 | 92.9 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
1093 | 2081 | 2081.0 | 39.38 | 39.4 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
1094 | 2080 | 2080.0 | 53.03 | 53.0 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | No |
1095 | 10399 | 2079.8 | 241.2 | 48.2 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
1096 | 2078 | 2078.0 | 71.82 | 71.8 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
1097 | 4155 | 2077.5 | 78.46 | 39.2 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
1098 | 4153 | 2076.5 | 109.83 | 54.9 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
1099 | 4152 | 2076.0 | 81.81 | 40.9 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
1100 | 4152 | 2076.0 | 82.05 | 41.0 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
1101 | 8293 | 2073.2 | 272.19 | 68.0 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
1102 | 2072 | 2072.0 | 59.86 | 59.9 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
1103 | 2072 | 2072.0 | 50.76 | 50.8 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
1104 | 4143 | 2071.5 | 80.79 | 40.4 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
1105 | 4143 | 2071.5 | 35.75 | 17.9 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
1106 | 2071 | 2071.0 | 50.53 | 50.5 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
1107 | 4142 | 2071.0 | 118.26 | 59.1 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
1108 | 2065 | 2065.0 | 37.83 | 37.8 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
1109 | 4129 | 2064.5 | 129.54 | 64.8 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
1110 | 2064 | 2064.0 | 52.81 | 52.8 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
1111 | 2064 | 2064.0 | 41.39 | 41.4 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
1112 | 2064 | 2064.0 | 129.74 | 129.7 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | No |
1113 | 2061 | 2061.0 | 39.7 | 39.7 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
1114 | 4121 | 2060.5 | 85.95 | 43.0 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
1115 | 2058 | 2058.0 | 42.59 | 42.6 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
1116 | 4113 | 2056.5 | 105.05 | 52.5 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
1117 | 6169 | 2056.3 | 202.15 | 67.4 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
1118 | 4112 | 2056.0 | 122.65 | 61.3 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
1119 | 2055 | 2055.0 | 52.28 | 52.3 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
1120 | 4109 | 2054.5 | 101.25 | 50.6 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
1121 | 4107 | 2053.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
1122 | 4105 | 2052.5 | 177.44 | 88.7 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
1123 | 2052 | 2052.0 | 18.77 | 18.8 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
1124 | 2052 | 2052.0 | 60.61 | 60.6 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
1125 | 2051 | 2051.0 | 24.81 | 24.8 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
1126 | 2051 | 2051.0 | 47.81 | 47.8 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
1127 | 6150 | 2050.0 | 198.09 | 66.0 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
1128 | 2049 | 2049.0 | 64.92 | 64.9 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
1129 | 2048 | 2048.0 | 47.84 | 47.8 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
1130 | 4087 | 2043.5 | 110.53 | 55.3 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
1131 | 2043 | 2043.0 | 41.8 | 41.8 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
1132 | 4083 | 2041.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
1133 | 2041 | 2041.0 | 56.48 | 56.5 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
1134 | 2037 | 2037.0 | 61.14 | 61.1 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
1135 | 2037 | 2037.0 | 120.53 | 120.5 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
1136 | 2035 | 2035.0 | 63.62 | 63.6 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | No |
1137 | 4063 | 2031.5 | 97.6 | 48.8 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
1138 | 4060 | 2030.0 | 98.24 | 49.1 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
1139 | 2030 | 2030.0 | 39.12 | 39.1 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
1140 | 8112 | 2028.0 | 304.9 | 76.2 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
1141 | 2028 | 2028.0 | 47.6 | 47.6 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
1142 | 2027 | 2027.0 | 79.71 | 79.7 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
1143 | 2027 | 2027.0 | 72.09 | 72.1 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
1144 | 4052 | 2026.0 | 94.69 | 47.3 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
1145 | 4050 | 2025.0 | 79.48 | 39.7 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
1146 | 2024 | 2024.0 | 62.12 | 62.1 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
1147 | 12144 | 2024.0 | 375.12 | 62.5 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
1148 | 6066 | 2022.0 | 182.91 | 61.0 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
1149 | 2021 | 2021.0 | 52.51 | 52.5 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
1150 | 2021 | 2021.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
1151 | 2021 | 2021.0 | 55.31 | 55.3 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
1152 | 4042 | 2021.0 | 136.19 | 68.1 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
1153 | 6061 | 2020.3 | 228.14 | 76.0 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
1154 | 2019 | 2019.0 | 42.48 | 42.5 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
1155 | 2017 | 2017.0 | 44.15 | 44.1 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
1156 | 2017 | 2017.0 | 44.17 | 44.2 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
1157 | 2016 | 2016.0 | 46.86 | 46.9 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
1158 | 6045 | 2015.0 | 162.63 | 54.2 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
1159 | 2013 | 2013.0 | 38.76 | 38.8 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
1160 | 2012 | 2012.0 | 58.33 | 58.3 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
1161 | 2011 | 2011.0 | 83.73 | 83.7 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
1162 | 2011 | 2011.0 | 95.97 | 96.0 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
1163 | 4021 | 2010.5 | 119.45 | 59.7 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
1164 | 2010 | 2010.0 | 22.26 | 22.3 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
1165 | 2010 | 2010.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
1166 | 2009 | 2009.0 | 51.11 | 51.1 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
1167 | 2009 | 2009.0 | 68.42 | 68.4 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
1168 | 2008 | 2008.0 | 41.63 | 41.6 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
1169 | 8030 | 2007.5 | 194.63 | 48.7 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
1170 | 2005 | 2005.0 | 48.3 | 48.3 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
1171 | 2005 | 2005.0 | 34.61 | 34.6 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
1172 | 8018 | 2004.5 | 327.59 | 81.9 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
1173 | 2002 | 2002.0 | 36.67 | 36.7 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
1174 | 2002 | 2002.0 | 50.17 | 50.2 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
1175 | 4004 | 2002.0 | 88.24 | 44.1 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
1176 | 8003 | 2000.8 | 236.19 | 59.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
1177 | 4001 | 2000.5 | 117.65 | 58.8 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
1178 | 2000 | 2000.0 | 39.53 | 39.5 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
1179 | 2000 | 2000.0 | 54.96 | 55.0 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
1180 | 21993 | 1999.4 | 546.45 | 49.7 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
1181 | 1999 | 1999.0 | 43.8 | 43.8 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
1182 | 1999 | 1999.0 | 55.95 | 56.0 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
1183 | 13993 | 1999.0 | 307.49 | 43.9 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
1184 | 1997 | 1997.0 | 43.51 | 43.5 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
1185 | 1994 | 1994.0 | 101.4 | 101.4 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
1186 | 3987 | 1993.5 | 91.26 | 45.6 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
1187 | 3986 | 1993.0 | 90.24 | 45.1 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
1188 | 1992 | 1992.0 | 41.47 | 41.5 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
1189 | 1991 | 1991.0 | 38.7 | 38.7 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
1190 | 1991 | 1991.0 | 42.49 | 42.5 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
1191 | 3982 | 1991.0 | 87.77 | 43.9 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
1192 | 3980 | 1990.0 | 89.82 | 44.9 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
1193 | 1989 | 1989.0 | 54.77 | 54.8 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
1194 | 3978 | 1989.0 | 85.44 | 42.7 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
1195 | 1988 | 1988.0 | 47.72 | 47.7 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
1196 | 1987 | 1987.0 | 39.16 | 39.2 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
1197 | 1987 | 1987.0 | 70.24 | 70.2 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
1198 | 1987 | 1987.0 | 116.6 | 116.6 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
1199 | 3972 | 1986.0 | 86.24 | 43.1 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
1200 | 1985 | 1985.0 | 40.71 | 40.7 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
1201 | 3970 | 1985.0 | 141.79 | 70.9 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
1202 | 1985 | 1985.0 | 48.54 | 48.5 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
1203 | 3970 | 1985.0 | 137.52 | 68.8 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
1204 | 13889 | 1984.1 | 316.27 | 45.2 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
1205 | 1984 | 1984.0 | 65.91 | 65.9 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
1206 | 1982 | 1982.0 | 63.04 | 63.0 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
1207 | 3960 | 1980.0 | 110.67 | 55.3 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
1208 | 1980 | 1980.0 | 61.53 | 61.5 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
1209 | 3951 | 1975.5 | 98.04 | 49.0 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
1210 | 1975 | 1975.0 | 48.21 | 48.2 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
1211 | 3947 | 1973.5 | 108.35 | 54.2 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
1212 | 1973 | 1973.0 | 49.3 | 49.3 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
1213 | 1970 | 1970.0 | 62.5 | 62.5 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
1214 | 1970 | 1970.0 | 52.6 | 52.6 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
1215 | 5908 | 1969.3 | 191.99 | 64.0 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
1216 | 1967 | 1967.0 | 86.83 | 86.8 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
1217 | 1966 | 1966.0 | 61.63 | 61.6 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
1218 | 1965 | 1965.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
1219 | 1964 | 1964.0 | 34.79 | 34.8 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
1220 | 3921 | 1960.5 | 96.37 | 48.2 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
1221 | 1960 | 1960.0 | 57.71 | 57.7 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
1222 | 3919 | 1959.5 | 125.53 | 62.8 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
1223 | 1959 | 1959.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
1224 | 1958 | 1958.0 | 41.07 | 41.1 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
1225 | 1958 | 1958.0 | 34.11 | 34.1 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
1226 | 1958 | 1958.0 | 60.09 | 60.1 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
1227 | 1957 | 1957.0 | 45.81 | 45.8 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
1228 | 1957 | 1957.0 | 37.32 | 37.3 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
1229 | 1956 | 1956.0 | 45.08 | 45.1 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
1230 | 1955 | 1955.0 | 62.41 | 62.4 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
1231 | 3909 | 1954.5 | 132.22 | 66.1 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
1232 | 1953 | 1953.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
1233 | 3906 | 1953.0 | 60.09 | 30.0 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
1234 | 3898 | 1949.0 | 95.31 | 47.7 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
1235 | 1949 | 1949.0 | 61.18 | 61.2 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
1236 | 5846 | 1948.7 | 106.92 | 35.6 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
1237 | 1947 | 1947.0 | 39.36 | 39.4 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
1238 | 1946 | 1946.0 | 79.1 | 79.1 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
1239 | 3892 | 1946.0 | 65.22 | 32.6 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
1240 | 1946 | 1946.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
1241 | 1945 | 1945.0 | 37.53 | 37.5 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
1242 | 1945 | 1945.0 | 38.92 | 38.9 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
1243 | 1944 | 1944.0 | 39.78 | 39.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
1244 | 5829 | 1943.0 | 120.0 | 40.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
1245 | 1943 | 1943.0 | 40.44 | 40.4 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
1246 | 1940 | 1940.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
1247 | 1939 | 1939.0 | 41.15 | 41.1 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
1248 | 3877 | 1938.5 | 90.59 | 45.3 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | No |
1249 | 3875 | 1937.5 | 121.73 | 60.9 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
1250 | 1937 | 1937.0 | 64.43 | 64.4 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
1251 | 1937 | 1937.0 | 49.98 | 50.0 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
1252 | 5804 | 1934.7 | 168.81 | 56.3 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
1253 | 1934 | 1934.0 | 60.54 | 60.5 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
1254 | 3868 | 1934.0 | 122.79 | 61.4 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
1255 | 7733 | 1933.2 | 186.73 | 46.7 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
1256 | 1932 | 1932.0 | 55.21 | 55.2 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
1257 | 1932 | 1932.0 | 57.61 | 57.6 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
1258 | 1932 | 1932.0 | 42.22 | 42.2 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
1259 | 1931 | 1931.0 | 23.2 | 23.2 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
1260 | 1929 | 1929.0 | 46.73 | 46.7 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
1261 | 1928 | 1928.0 | 50.65 | 50.6 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
1262 | 1927 | 1927.0 | 42.7 | 42.7 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
1263 | 5779 | 1926.3 | 190.6 | 63.5 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
1264 | 3851 | 1925.5 | 94.39 | 47.2 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
1265 | 3850 | 1925.0 | 102.67 | 51.3 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
1266 | 1925 | 1925.0 | 43.06 | 43.1 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
1267 | 3850 | 1925.0 | 122.15 | 61.1 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
1268 | 1924 | 1924.0 | 44.45 | 44.5 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
1269 | 1923 | 1923.0 | 41.68 | 41.7 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
1270 | 3846 | 1923.0 | 73.53 | 36.8 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
1271 | 1922 | 1922.0 | 83.64 | 83.6 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
1272 | 3844 | 1922.0 | 130.5 | 65.2 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
1273 | 1922 | 1922.0 | 45.5 | 45.5 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
1274 | 1922 | 1922.0 | 58.43 | 58.4 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
1275 | 3836 | 1918.0 | 98.74 | 49.4 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
1276 | 1918 | 1918.0 | 56.38 | 56.4 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
1277 | 1917 | 1917.0 | 63.13 | 63.1 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
1278 | 1917 | 1917.0 | 33.81 | 33.8 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
1279 | 1917 | 1917.0 | 39.09 | 39.1 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
1280 | 3833 | 1916.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
1281 | 1916 | 1916.0 | 59.8 | 59.8 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
1282 | 1915 | 1915.0 | 40.06 | 40.1 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
1283 | 1915 | 1915.0 | 46.98 | 47.0 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
1284 | 1915 | 1915.0 | 46.21 | 46.2 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
1285 | 1914 | 1914.0 | 53.22 | 53.2 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
1286 | 7654 | 1913.5 | 297.99 | 74.5 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
1287 | 1913 | 1913.0 | 43.12 | 43.1 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
1288 | 7650 | 1912.5 | 188.43 | 47.1 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
1289 | 3825 | 1912.5 | 84.84 | 42.4 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
1290 | 1912 | 1912.0 | 54.76 | 54.8 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
1291 | 1912 | 1912.0 | 44.83 | 44.8 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
1292 | 7646 | 1911.5 | 185.87 | 46.5 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
1293 | 1909 | 1909.0 | 46.19 | 46.2 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
1294 | 3814 | 1907.0 | 115.11 | 57.6 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
1295 | 1907 | 1907.0 | 51.46 | 51.5 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
1296 | 3813 | 1906.5 | 129.9 | 65.0 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
1297 | 5718 | 1906.0 | 197.89 | 66.0 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
1298 | 1904 | 1904.0 | 53.77 | 53.8 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
1299 | 1904 | 1904.0 | 63.06 | 63.1 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
1300 | 3806 | 1903.0 | 136.89 | 68.4 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
1301 | 3804 | 1902.0 | 153.39 | 76.7 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
1302 | 5704 | 1901.3 | 145.07 | 48.4 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
1303 | 3802 | 1901.0 | 334.25 | 167.1 | WHO Declares COVID-19 a Pandemic. | Domenico Cucinotta, Maurizio Vanelli | Acta Biomed | 2020 | 32191675 | Yes |
1304 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
1305 | 1900 | 1900.0 | 40.49 | 40.5 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
1306 | 1899 | 1899.0 | 74.09 | 74.1 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
1307 | 15191 | 1898.9 | 630.15 | 78.8 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner | Nucleic Acids Res | 2013 | 23193283 | Yes |
1308 | 1898 | 1898.0 | 53.29 | 53.3 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
1309 | 1897 | 1897.0 | 65.33 | 65.3 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
1310 | 1896 | 1896.0 | 53.4 | 53.4 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
1311 | 1896 | 1896.0 | 69.54 | 69.5 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
1312 | 3791 | 1895.5 | 137.82 | 68.9 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
1313 | 5684 | 1894.7 | 341.56 | 113.9 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
1314 | 3787 | 1893.5 | 156.64 | 78.3 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
1315 | 1893 | 1893.0 | 41.08 | 41.1 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
1316 | 1893 | 1893.0 | 50.07 | 50.1 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
1317 | 5675 | 1891.7 | 431.97 | 144.0 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
1318 | 3783 | 1891.5 | 118.12 | 59.1 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
1319 | 3780 | 1890.0 | 84.81 | 42.4 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
1320 | 15118 | 1889.8 | 368.78 | 46.1 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
1321 | 3779 | 1889.5 | 107.34 | 53.7 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
1322 | 1888 | 1888.0 | 45.48 | 45.5 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
1323 | 1887 | 1887.0 | 60.19 | 60.2 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
1324 | 1887 | 1887.0 | 69.14 | 69.1 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
1325 | 3772 | 1886.0 | 104.24 | 52.1 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | No |
1326 | 3772 | 1886.0 | 68.42 | 34.2 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
1327 | 1885 | 1885.0 | 79.09 | 79.1 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
1328 | 3768 | 1884.0 | 112.61 | 56.3 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
1329 | 7533 | 1883.2 | 252.83 | 63.2 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
1330 | 1883 | 1883.0 | 16.0 | 16.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
1331 | 1882 | 1882.0 | 68.91 | 68.9 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
1332 | 1882 | 1882.0 | 48.22 | 48.2 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
1333 | 3762 | 1881.0 | 89.62 | 44.8 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
1334 | 1880 | 1880.0 | 41.12 | 41.1 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
1335 | 3759 | 1879.5 | 86.14 | 43.1 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
1336 | 9381 | 1876.2 | 221.52 | 44.3 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
1337 | 1875 | 1875.0 | 53.57 | 53.6 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
1338 | 1874 | 1874.0 | 49.08 | 49.1 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
1339 | 3746 | 1873.0 | 86.07 | 43.0 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
1340 | 1873 | 1873.0 | 60.26 | 60.3 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
1341 | 1871 | 1871.0 | 86.74 | 86.7 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
1342 | 3742 | 1871.0 | 77.51 | 38.8 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
1343 | 1870 | 1870.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
1344 | 1870 | 1870.0 | 44.49 | 44.5 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
1345 | 3739 | 1869.5 | 78.45 | 39.2 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
1346 | 1869 | 1869.0 | 39.94 | 39.9 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
1347 | 3737 | 1868.5 | 125.52 | 62.8 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
1348 | 5602 | 1867.3 | 775.71 | 258.6 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
1349 | 1867 | 1867.0 | 50.79 | 50.8 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
1350 | 13062 | 1866.0 | 465.02 | 66.4 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
1351 | 1865 | 1865.0 | 43.95 | 44.0 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
1352 | 3730 | 1865.0 | 142.87 | 71.4 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
1353 | 1864 | 1864.0 | 37.4 | 37.4 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
1354 | 5592 | 1864.0 | 125.24 | 41.7 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
1355 | 1864 | 1864.0 | 41.88 | 41.9 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
1356 | 3720 | 1860.0 | 78.61 | 39.3 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
1357 | 1860 | 1860.0 | 54.35 | 54.4 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
1358 | 1860 | 1860.0 | 114.6 | 114.6 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | No |
1359 | 1859 | 1859.0 | 48.7 | 48.7 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
1360 | 3717 | 1858.5 | 82.52 | 41.3 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
1361 | 1858 | 1858.0 | 52.09 | 52.1 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
1362 | 1857 | 1857.0 | 41.19 | 41.2 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
1363 | 1856 | 1856.0 | 41.68 | 41.7 | Global cancer statistics in the year 2000. | D M Parkin | Lancet Oncol | 2001 | 11905707 | No |
1364 | 1855 | 1855.0 | 56.11 | 56.1 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
1365 | 1855 | 1855.0 | 50.49 | 50.5 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
1366 | 5562 | 1854.0 | 234.21 | 78.1 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
1367 | 7415 | 1853.8 | 205.65 | 51.4 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
1368 | 1853 | 1853.0 | 45.3 | 45.3 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
1369 | 1851 | 1851.0 | 85.07 | 85.1 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
1370 | 3702 | 1851.0 | 76.72 | 38.4 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
1371 | 7404 | 1851.0 | 178.87 | 44.7 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
1372 | 3702 | 1851.0 | 105.48 | 52.7 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
1373 | 5552 | 1850.7 | 138.75 | 46.2 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
1374 | 14777 | 1847.1 | 415.3 | 51.9 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
1375 | 1847 | 1847.0 | 48.5 | 48.5 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
1376 | 3690 | 1845.0 | 99.8 | 49.9 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
1377 | 3690 | 1845.0 | 52.78 | 26.4 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
1378 | 1843 | 1843.0 | 52.94 | 52.9 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
1379 | 3685 | 1842.5 | 128.66 | 64.3 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
1380 | 5525 | 1841.7 | 121.96 | 40.7 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
1381 | 1841 | 1841.0 | 45.02 | 45.0 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. | Fiona Turnbull | Lancet | 2003 | 14615107 | Yes |
1382 | 3678 | 1839.0 | 120.22 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
1383 | 3678 | 1839.0 | 110.48 | 55.2 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
1384 | 1838 | 1838.0 | 41.4 | 41.4 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
1385 | 3674 | 1837.0 | 76.3 | 38.1 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
1386 | 7346 | 1836.5 | 339.75 | 84.9 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
1387 | 1836 | 1836.0 | 76.85 | 76.8 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
1388 | 3671 | 1835.5 | 246.52 | 123.3 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
1389 | 1835 | 1835.0 | 68.1 | 68.1 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
1390 | 1835 | 1835.0 | 35.32 | 35.3 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
1391 | 1834 | 1834.0 | 53.84 | 53.8 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
1392 | 1833 | 1833.0 | 44.53 | 44.5 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
1393 | 1833 | 1833.0 | 41.1 | 41.1 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
1394 | 1833 | 1833.0 | 17.75 | 17.8 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
1395 | 1833 | 1833.0 | 36.33 | 36.3 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
1396 | 5497 | 1832.3 | 121.18 | 40.4 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
1397 | 3664 | 1832.0 | 87.9 | 44.0 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
1398 | 1831 | 1831.0 | 56.43 | 56.4 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
1399 | 10980 | 1830.0 | 320.59 | 53.4 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
1400 | 1829 | 1829.0 | 36.57 | 36.6 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
1401 | 3653 | 1826.5 | 111.5 | 55.8 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
1402 | 1824 | 1824.0 | 50.02 | 50.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
1403 | 1823 | 1823.0 | 65.96 | 66.0 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
1404 | 3646 | 1823.0 | 124.76 | 62.4 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | No |
1405 | 1821 | 1821.0 | 49.59 | 49.6 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
1406 | 1821 | 1821.0 | 51.19 | 51.2 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
1407 | 1821 | 1821.0 | 45.48 | 45.5 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
1408 | 1820 | 1820.0 | 70.0 | 70.0 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
1409 | 1816 | 1816.0 | 48.44 | 48.4 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
1410 | 3631 | 1815.5 | 86.97 | 43.5 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
1411 | 5443 | 1814.3 | 102.79 | 34.3 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
1412 | 3627 | 1813.5 | 92.46 | 46.2 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
1413 | 1813 | 1813.0 | 53.8 | 53.8 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
1414 | 1813 | 1813.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
1415 | 1813 | 1813.0 | 39.79 | 39.8 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
1416 | 1811 | 1811.0 | 55.07 | 55.1 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
1417 | 5429 | 1809.7 | 166.16 | 55.4 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
1418 | 3619 | 1809.5 | 87.3 | 43.6 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
1419 | 1809 | 1809.0 | 19.8 | 19.8 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
1420 | 5426 | 1808.7 | 113.03 | 37.7 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
1421 | 1808 | 1808.0 | 59.07 | 59.1 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
1422 | 3614 | 1807.0 | 101.98 | 51.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
1423 | 1807 | 1807.0 | 49.07 | 49.1 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
1424 | 3613 | 1806.5 | 93.0 | 46.5 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
1425 | 9025 | 1805.0 | 235.48 | 47.1 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
1426 | 1804 | 1804.0 | 65.95 | 66.0 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
1427 | 3605 | 1802.5 | 116.46 | 58.2 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
1428 | 1802 | 1802.0 | 35.47 | 35.5 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
1429 | 1802 | 1802.0 | 42.5 | 42.5 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
1430 | 1801 | 1801.0 | 56.42 | 56.4 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
1431 | 1800 | 1800.0 | 42.55 | 42.5 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
1432 | 1800 | 1800.0 | 36.33 | 36.3 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
1433 | 1800 | 1800.0 | 136.29 | 136.3 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | No |
1434 | 5398 | 1799.3 | 142.58 | 47.5 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
1435 | 7197 | 1799.2 | 273.53 | 68.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
1436 | 1799 | 1799.0 | 39.01 | 39.0 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
1437 | 3593 | 1796.5 | 126.62 | 63.3 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
1438 | 1796 | 1796.0 | 48.08 | 48.1 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
1439 | 1796 | 1796.0 | 44.03 | 44.0 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
1440 | 1794 | 1794.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
1441 | 3588 | 1794.0 | 158.31 | 79.2 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
1442 | 10762 | 1793.7 | 321.24 | 53.5 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
1443 | 1793 | 1793.0 | 43.03 | 43.0 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
1444 | 3584 | 1792.0 | 83.31 | 41.7 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
1445 | 1791 | 1791.0 | 62.48 | 62.5 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
1446 | 1790 | 1790.0 | 98.05 | 98.0 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
1447 | 1790 | 1790.0 | 71.82 | 71.8 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
1448 | 3579 | 1789.5 | 160.78 | 80.4 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
1449 | 3578 | 1789.0 | 85.83 | 42.9 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
1450 | 1789 | 1789.0 | 18.61 | 18.6 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
1451 | 1789 | 1789.0 | 36.54 | 36.5 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
1452 | 1789 | 1789.0 | 36.4 | 36.4 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
1453 | 1789 | 1789.0 | 49.5 | 49.5 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
1454 | 3577 | 1788.5 | 71.16 | 35.6 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
1455 | 1788 | 1788.0 | 54.44 | 54.4 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
1456 | 3575 | 1787.5 | 180.69 | 90.3 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
1457 | 3575 | 1787.5 | 99.26 | 49.6 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
1458 | 1787 | 1787.0 | 58.49 | 58.5 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
1459 | 3574 | 1787.0 | 70.59 | 35.3 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
1460 | 5351 | 1783.7 | 140.92 | 47.0 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw | Lancet | 2005 | 16182882 | Yes |
1461 | 8918 | 1783.6 | 296.55 | 59.3 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
1462 | 3566 | 1783.0 | 142.43 | 71.2 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
1463 | 3566 | 1783.0 | 128.74 | 64.4 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
1464 | 1782 | 1782.0 | 59.3 | 59.3 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
1465 | 7128 | 1782.0 | 138.5 | 34.6 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
1466 | 1782 | 1782.0 | 32.69 | 32.7 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
1467 | 12458 | 1779.7 | 300.17 | 42.9 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan | N Engl J Med | 2002 | 11832527 | Yes |
1468 | 1779 | 1779.0 | 36.76 | 36.8 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
1469 | 3557 | 1778.5 | 134.65 | 67.3 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
1470 | 3555 | 1777.5 | 88.05 | 44.0 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
1471 | 12438 | 1776.9 | 415.59 | 59.4 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann | BMJ | 2008 | 18436948 | Yes |
1472 | 1776 | 1776.0 | 36.26 | 36.3 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
1473 | 1776 | 1776.0 | 59.12 | 59.1 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
1474 | 1775 | 1775.0 | 35.99 | 36.0 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
1475 | 7100 | 1775.0 | 233.66 | 58.4 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
1476 | 1774 | 1774.0 | 71.23 | 71.2 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | No |
1477 | 1773 | 1773.0 | 60.93 | 60.9 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
1478 | 3546 | 1773.0 | 79.84 | 39.9 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
1479 | 3545 | 1772.5 | 109.65 | 54.8 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
1480 | 1770 | 1770.0 | 72.91 | 72.9 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
1481 | 1770 | 1770.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
1482 | 3539 | 1769.5 | 88.42 | 44.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
1483 | 3539 | 1769.5 | 73.56 | 36.8 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
1484 | 1769 | 1769.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
1485 | 1768 | 1768.0 | 42.16 | 42.2 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
1486 | 1768 | 1768.0 | 58.66 | 58.7 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
1487 | 7068 | 1767.0 | 297.7 | 74.4 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
1488 | 1767 | 1767.0 | 55.59 | 55.6 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
1489 | 1766 | 1766.0 | 57.41 | 57.4 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
1490 | 3532 | 1766.0 | 90.3 | 45.1 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
1491 | 1765 | 1765.0 | 43.94 | 43.9 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
1492 | 1763 | 1763.0 | 66.09 | 66.1 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
1493 | 1763 | 1763.0 | 53.13 | 53.1 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
1494 | 1763 | 1763.0 | 46.46 | 46.5 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
1495 | 17625 | 1762.5 | 552.12 | 55.2 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
1496 | 3525 | 1762.5 | 74.68 | 37.3 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
1497 | 1762 | 1762.0 | 49.11 | 49.1 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
1498 | 1762 | 1762.0 | 39.02 | 39.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
1499 | 1762 | 1762.0 | 42.25 | 42.2 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
1500 | 1761 | 1761.0 | 46.13 | 46.1 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
1501 | 1760 | 1760.0 | 47.5 | 47.5 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
1502 | 1760 | 1760.0 | 57.06 | 57.1 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
1503 | 3519 | 1759.5 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
1504 | 3519 | 1759.5 | 88.46 | 44.2 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon | J Thromb Haemost | 2005 | 15842354 | Yes |
1505 | 1759 | 1759.0 | 40.62 | 40.6 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
1506 | 1759 | 1759.0 | 46.6 | 46.6 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
1507 | 3518 | 1759.0 | 45.62 | 22.8 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
1508 | 1758 | 1758.0 | 66.47 | 66.5 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
1509 | 3514 | 1757.0 | 86.55 | 43.3 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
1510 | 1756 | 1756.0 | 42.53 | 42.5 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
1511 | 3512 | 1756.0 | 95.97 | 48.0 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
1512 | 1755 | 1755.0 | 41.61 | 41.6 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
1513 | 1754 | 1754.0 | 40.1 | 40.1 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
1514 | 3508 | 1754.0 | 82.61 | 41.3 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
1515 | 3508 | 1754.0 | 104.26 | 52.1 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
1516 | 1751 | 1751.0 | 61.09 | 61.1 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
1517 | 3501 | 1750.5 | 92.89 | 46.4 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
1518 | 1750 | 1750.0 | 32.97 | 33.0 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
1519 | 5245 | 1748.3 | 117.95 | 39.3 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
1520 | 1748 | 1748.0 | 38.58 | 38.6 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | No |
1521 | 1748 | 1748.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
1522 | 3495 | 1747.5 | 163.79 | 81.9 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
1523 | 5242 | 1747.3 | 135.25 | 45.1 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
1524 | 1747 | 1747.0 | 44.45 | 44.5 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
1525 | 3491 | 1745.5 | 92.44 | 46.2 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
1526 | 1745 | 1745.0 | 37.87 | 37.9 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
1527 | 1745 | 1745.0 | 42.19 | 42.2 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
1528 | 1745 | 1745.0 | 33.61 | 33.6 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
1529 | 3489 | 1744.5 | 150.59 | 75.3 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
1530 | 3489 | 1744.5 | 70.33 | 35.2 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
1531 | 1744 | 1744.0 | 46.85 | 46.9 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
1532 | 3486 | 1743.0 | 179.54 | 89.8 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
1533 | 1743 | 1743.0 | 40.67 | 40.7 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
1534 | 1743 | 1743.0 | 69.54 | 69.5 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
1535 | 3485 | 1742.5 | 135.92 | 68.0 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
1536 | 13940 | 1742.5 | 401.98 | 50.2 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
1537 | 1741 | 1741.0 | 65.21 | 65.2 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | No |
1538 | 6962 | 1740.5 | 135.86 | 34.0 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
1539 | 3481 | 1740.5 | 72.98 | 36.5 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
1540 | 3480 | 1740.0 | 98.19 | 49.1 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
1541 | 8698 | 1739.6 | 197.62 | 39.5 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
1542 | 1737 | 1737.0 | 73.89 | 73.9 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
1543 | 1735 | 1735.0 | 56.68 | 56.7 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
1544 | 3470 | 1735.0 | 138.87 | 69.4 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
1545 | 1734 | 1734.0 | 38.84 | 38.8 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
1546 | 1734 | 1734.0 | 61.86 | 61.9 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
1547 | 8667 | 1733.4 | 325.69 | 65.1 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
1548 | 1733 | 1733.0 | 62.56 | 62.6 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
1549 | 1733 | 1733.0 | 54.17 | 54.2 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
1550 | 1733 | 1733.0 | 50.02 | 50.0 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
1551 | 1733 | 1733.0 | 37.31 | 37.3 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
1552 | 1732 | 1732.0 | 39.47 | 39.5 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
1553 | 3464 | 1732.0 | 74.36 | 37.2 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
1554 | 5196 | 1732.0 | 186.28 | 62.1 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
1555 | 5194 | 1731.3 | 135.65 | 45.2 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
1556 | 8653 | 1730.6 | 213.32 | 42.7 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
1557 | 5189 | 1729.7 | 112.34 | 37.4 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
1558 | 5188 | 1729.3 | 155.43 | 51.8 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
1559 | 3458 | 1729.0 | 93.92 | 47.0 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
1560 | 1729 | 1729.0 | 59.35 | 59.4 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
1561 | 3457 | 1728.5 | 90.65 | 45.3 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
1562 | 1728 | 1728.0 | 41.09 | 41.1 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
1563 | 1728 | 1728.0 | 37.39 | 37.4 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
1564 | 1728 | 1728.0 | 45.75 | 45.8 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
1565 | 1727 | 1727.0 | 56.27 | 56.3 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
1566 | 1726 | 1726.0 | 61.26 | 61.3 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
1567 | 1726 | 1726.0 | 79.2 | 79.2 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | No |
1568 | 3449 | 1724.5 | 131.52 | 65.8 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
1569 | 1724 | 1724.0 | 56.42 | 56.4 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
1570 | 1724 | 1724.0 | 70.85 | 70.8 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
1571 | 1724 | 1724.0 | 40.6 | 40.6 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
1572 | 1723 | 1723.0 | 37.6 | 37.6 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
1573 | 1721 | 1721.0 | 31.02 | 31.0 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
1574 | 1721 | 1721.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
1575 | 1721 | 1721.0 | 46.91 | 46.9 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
1576 | 3442 | 1721.0 | 113.12 | 56.6 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
1577 | 5162 | 1720.7 | 231.14 | 77.0 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
1578 | 1720 | 1720.0 | 56.5 | 56.5 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
1579 | 6878 | 1719.5 | 197.46 | 49.4 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
1580 | 1718 | 1718.0 | 56.65 | 56.6 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
1581 | 5153 | 1717.7 | 168.37 | 56.1 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
1582 | 3435 | 1717.5 | 103.86 | 51.9 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
1583 | 3434 | 1717.0 | 125.93 | 63.0 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
1584 | 3434 | 1717.0 | 70.13 | 35.1 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
1585 | 3434 | 1717.0 | 96.29 | 48.1 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
1586 | 3433 | 1716.5 | 86.57 | 43.3 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
1587 | 5145 | 1715.0 | 161.39 | 53.8 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
1588 | 5140 | 1713.3 | 113.02 | 37.7 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
1589 | 1713 | 1713.0 | 38.53 | 38.5 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
1590 | 1713 | 1713.0 | 59.52 | 59.5 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
1591 | 1713 | 1713.0 | 44.54 | 44.5 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
1592 | 1713 | 1713.0 | 51.42 | 51.4 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
1593 | 1712 | 1712.0 | 64.8 | 64.8 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
1594 | 1712 | 1712.0 | 41.92 | 41.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
1595 | 1712 | 1712.0 | 32.79 | 32.8 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
1596 | 1712 | 1712.0 | 45.46 | 45.5 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
1597 | 3422 | 1711.0 | 110.2 | 55.1 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
1598 | 1711 | 1711.0 | 31.38 | 31.4 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
1599 | 1711 | 1711.0 | 33.53 | 33.5 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
1600 | 1710 | 1710.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
1601 | 3418 | 1709.0 | 222.83 | 111.4 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
1602 | 3418 | 1709.0 | 86.42 | 43.2 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
1603 | 3417 | 1708.5 | 82.44 | 41.2 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
1604 | 3416 | 1708.0 | 146.19 | 73.1 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
1605 | 1708 | 1708.0 | 68.63 | 68.6 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
1606 | 5124 | 1708.0 | 295.01 | 98.3 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
1607 | 17073 | 1707.3 | 541.77 | 54.2 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
1608 | 1707 | 1707.0 | 52.43 | 52.4 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
1609 | 1707 | 1707.0 | 38.45 | 38.5 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
1610 | 1707 | 1707.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
1611 | 5119 | 1706.3 | 119.96 | 40.0 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
1612 | 1706 | 1706.0 | 39.25 | 39.2 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
1613 | 1706 | 1706.0 | 82.37 | 82.4 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
1614 | 3411 | 1705.5 | 108.18 | 54.1 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
1615 | 1705 | 1705.0 | 34.47 | 34.5 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
1616 | 6816 | 1704.0 | 143.42 | 35.9 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
1617 | 3408 | 1704.0 | 140.41 | 70.2 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
1618 | 3407 | 1703.5 | 78.27 | 39.1 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
1619 | 1703 | 1703.0 | 31.17 | 31.2 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
1620 | 1703 | 1703.0 | 36.8 | 36.8 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
1621 | 1702 | 1702.0 | 52.19 | 52.2 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
1622 | 3402 | 1701.0 | 50.63 | 25.3 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
1623 | 1701 | 1701.0 | 82.15 | 82.2 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | No |
1624 | 6802 | 1700.5 | 196.21 | 49.1 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
1625 | 3401 | 1700.5 | 92.34 | 46.2 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
1626 | 10200 | 1700.0 | 284.5 | 47.4 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
1627 | 1700 | 1700.0 | 39.52 | 39.5 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
1628 | 3400 | 1700.0 | 87.69 | 43.8 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
1629 | 1699 | 1699.0 | 41.37 | 41.4 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
1630 | 1699 | 1699.0 | 53.24 | 53.2 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
1631 | 1698 | 1698.0 | 55.11 | 55.1 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
1632 | 1697 | 1697.0 | 42.87 | 42.9 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
1633 | 3392 | 1696.0 | 81.24 | 40.6 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
1634 | 1696 | 1696.0 | 18.27 | 18.3 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
1635 | 1695 | 1695.0 | 73.12 | 73.1 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
1636 | 3390 | 1695.0 | 70.59 | 35.3 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
1637 | 1695 | 1695.0 | 31.19 | 31.2 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
1638 | 1695 | 1695.0 | 35.99 | 36.0 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
1639 | 1695 | 1695.0 | 58.61 | 58.6 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
1640 | 8473 | 1694.6 | 91.67 | 18.3 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
1641 | 3389 | 1694.5 | 93.6 | 46.8 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
1642 | 1694 | 1694.0 | 40.08 | 40.1 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
1643 | 3388 | 1694.0 | 92.51 | 46.3 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
1644 | 6774 | 1693.5 | 266.44 | 66.6 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
1645 | 5080 | 1693.3 | 109.31 | 36.4 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
1646 | 1692 | 1692.0 | 38.97 | 39.0 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
1647 | 1691 | 1691.0 | 45.28 | 45.3 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
1648 | 1691 | 1691.0 | 51.59 | 51.6 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
1649 | 3380 | 1690.0 | 125.71 | 62.9 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
1650 | 1689 | 1689.0 | 42.72 | 42.7 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
1651 | 1688 | 1688.0 | 40.24 | 40.2 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
1652 | 1687 | 1687.0 | 29.33 | 29.3 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
1653 | 3374 | 1687.0 | 71.61 | 35.8 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
1654 | 1687 | 1687.0 | 36.65 | 36.6 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
1655 | 3373 | 1686.5 | 98.93 | 49.5 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
1656 | 1686 | 1686.0 | 20.11 | 20.1 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
1657 | 3372 | 1686.0 | 83.63 | 41.8 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
1658 | 1686 | 1686.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
1659 | 6740 | 1685.0 | 205.6 | 51.4 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
1660 | 1685 | 1685.0 | 41.28 | 41.3 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
1661 | 3369 | 1684.5 | 69.81 | 34.9 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
1662 | 1684 | 1684.0 | 39.86 | 39.9 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
1663 | 18516 | 1683.3 | 578.35 | 52.6 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh | Ann Intern Med | 2009 | 19414839 | Yes |
1664 | 3365 | 1682.5 | 82.81 | 41.4 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
1665 | 1681 | 1681.0 | 46.56 | 46.6 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
1666 | 1681 | 1681.0 | 50.21 | 50.2 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
1667 | 1680 | 1680.0 | 62.04 | 62.0 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
1668 | 1680 | 1680.0 | 32.93 | 32.9 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
1669 | 1680 | 1680.0 | 38.62 | 38.6 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
1670 | 1680 | 1680.0 | 42.86 | 42.9 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
1671 | 1679 | 1679.0 | 30.99 | 31.0 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
1672 | 1679 | 1679.0 | 50.88 | 50.9 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
1673 | 6715 | 1678.8 | 222.41 | 55.6 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
1674 | 5036 | 1678.7 | 198.85 | 66.3 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
1675 | 1678 | 1678.0 | 58.39 | 58.4 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
1676 | 1678 | 1678.0 | 39.51 | 39.5 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
1677 | 1677 | 1677.0 | 64.4 | 64.4 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
1678 | 1677 | 1677.0 | 49.22 | 49.2 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
1679 | 1677 | 1677.0 | 30.76 | 30.8 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
1680 | 3354 | 1677.0 | 78.27 | 39.1 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
1681 | 1677 | 1677.0 | 14.05 | 14.1 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
1682 | 1677 | 1677.0 | 35.99 | 36.0 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
1683 | 1677 | 1677.0 | 47.01 | 47.0 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
1684 | 1676 | 1676.0 | 58.61 | 58.6 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
1685 | 1676 | 1676.0 | 47.07 | 47.1 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
1686 | 1676 | 1676.0 | 46.32 | 46.3 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
1687 | 1676 | 1676.0 | 50.6 | 50.6 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
1688 | 3351 | 1675.5 | 79.08 | 39.5 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
1689 | 10049 | 1674.8 | 204.82 | 34.1 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
1690 | 3348 | 1674.0 | 216.8 | 108.4 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
1691 | 1674 | 1674.0 | 45.06 | 45.1 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
1692 | 1674 | 1674.0 | 53.51 | 53.5 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
1693 | 1673 | 1673.0 | 37.23 | 37.2 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
1694 | 5018 | 1672.7 | 264.82 | 88.3 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
1695 | 1671 | 1671.0 | 38.28 | 38.3 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
1696 | 11695 | 1670.7 | 345.3 | 49.3 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
1697 | 3341 | 1670.5 | 109.93 | 55.0 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
1698 | 3339 | 1669.5 | 53.79 | 26.9 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
1699 | 3339 | 1669.5 | 78.56 | 39.3 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
1700 | 1669 | 1669.0 | 82.2 | 82.2 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
1701 | 1668 | 1668.0 | 68.08 | 68.1 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
1702 | 1668 | 1668.0 | 74.52 | 74.5 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
1703 | 1668 | 1668.0 | 35.69 | 35.7 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
1704 | 1667 | 1667.0 | 31.79 | 31.8 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
1705 | 1667 | 1667.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
1706 | 1667 | 1667.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
1707 | 1665 | 1665.0 | 37.69 | 37.7 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
1708 | 1664 | 1664.0 | 52.59 | 52.6 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
1709 | 1664 | 1664.0 | 54.8 | 54.8 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
1710 | 1664 | 1664.0 | 32.23 | 32.2 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
1711 | 1664 | 1664.0 | 46.66 | 46.7 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
1712 | 1664 | 1664.0 | 47.1 | 47.1 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
1713 | 1663 | 1663.0 | 39.74 | 39.7 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
1714 | 1661 | 1661.0 | 59.66 | 59.7 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
1715 | 3321 | 1660.5 | 87.23 | 43.6 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
1716 | 3320 | 1660.0 | 66.79 | 33.4 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
1717 | 1658 | 1658.0 | 45.4 | 45.4 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
1718 | 3315 | 1657.5 | 154.66 | 77.3 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
1719 | 3314 | 1657.0 | 54.63 | 27.3 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
1720 | 1657 | 1657.0 | 53.62 | 53.6 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | No |
1721 | 3313 | 1656.5 | 83.99 | 42.0 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
1722 | 3312 | 1656.0 | 83.8 | 41.9 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
1723 | 1656 | 1656.0 | 23.8 | 23.8 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
1724 | 3311 | 1655.5 | 73.67 | 36.8 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
1725 | 1655 | 1655.0 | 41.84 | 41.8 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
1726 | 3310 | 1655.0 | 66.35 | 33.2 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
1727 | 3308 | 1654.0 | 58.75 | 29.4 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
1728 | 1654 | 1654.0 | 193.28 | 193.3 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
1729 | 6615 | 1653.8 | 152.68 | 38.2 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
1730 | 1653 | 1653.0 | 47.09 | 47.1 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
1731 | 6607 | 1651.8 | 287.32 | 71.8 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
1732 | 1651 | 1651.0 | 31.05 | 31.1 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
1733 | 1651 | 1651.0 | 33.16 | 33.2 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
1734 | 1650 | 1650.0 | 57.13 | 57.1 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
1735 | 3300 | 1650.0 | 75.16 | 37.6 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
1736 | 1649 | 1649.0 | 57.91 | 57.9 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
1737 | 9881 | 1646.8 | 227.73 | 38.0 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
1738 | 3293 | 1646.5 | 63.55 | 31.8 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
1739 | 3292 | 1646.0 | 117.63 | 58.8 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
1740 | 1646 | 1646.0 | 66.84 | 66.8 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
1741 | 3291 | 1645.5 | 71.25 | 35.6 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
1742 | 1645 | 1645.0 | 42.65 | 42.6 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
1743 | 1645 | 1645.0 | 73.17 | 73.2 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
1744 | 3289 | 1644.5 | 68.34 | 34.2 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
1745 | 4933 | 1644.3 | 116.8 | 38.9 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
1746 | 1644 | 1644.0 | 34.75 | 34.8 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
1747 | 1643 | 1643.0 | 53.95 | 54.0 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
1748 | 1643 | 1643.0 | 42.8 | 42.8 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
1749 | 1642 | 1642.0 | 48.57 | 48.6 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
1750 | 1642 | 1642.0 | 45.05 | 45.0 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
1751 | 4925 | 1641.7 | 103.68 | 34.6 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
1752 | 1641 | 1641.0 | 57.46 | 57.5 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
1753 | 1641 | 1641.0 | 48.67 | 48.7 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
1754 | 1640 | 1640.0 | 49.56 | 49.6 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
1755 | 1640 | 1640.0 | 40.51 | 40.5 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
1756 | 3280 | 1640.0 | 101.22 | 50.6 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
1757 | 1637 | 1637.0 | 37.29 | 37.3 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
1758 | 3272 | 1636.0 | 85.01 | 42.5 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
1759 | 1635 | 1635.0 | 33.25 | 33.2 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
1760 | 1635 | 1635.0 | 49.91 | 49.9 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
1761 | 1635 | 1635.0 | 29.07 | 29.1 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
1762 | 4903 | 1634.3 | 95.23 | 31.7 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
1763 | 1634 | 1634.0 | 40.68 | 40.7 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
1764 | 3265 | 1632.5 | 99.44 | 49.7 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
1765 | 1632 | 1632.0 | 56.54 | 56.5 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
1766 | 1631 | 1631.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
1767 | 1630 | 1630.0 | 40.51 | 40.5 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
1768 | 1629 | 1629.0 | 58.39 | 58.4 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
1769 | 1629 | 1629.0 | 42.46 | 42.5 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
1770 | 1629 | 1629.0 | 34.62 | 34.6 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
1771 | 11403 | 1629.0 | 316.37 | 45.2 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
1772 | 1628 | 1628.0 | 50.98 | 51.0 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
1773 | 1628 | 1628.0 | 70.95 | 71.0 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
1774 | 1628 | 1628.0 | 38.19 | 38.2 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
1775 | 1627 | 1627.0 | 56.68 | 56.7 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
1776 | 1627 | 1627.0 | 40.06 | 40.1 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
1777 | 1626 | 1626.0 | 45.14 | 45.1 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
1778 | 1626 | 1626.0 | 52.66 | 52.7 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
1779 | 1625 | 1625.0 | 58.13 | 58.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
1780 | 9747 | 1624.5 | 337.87 | 56.3 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
1781 | 6497 | 1624.2 | 220.71 | 55.2 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
1782 | 3248 | 1624.0 | 89.31 | 44.7 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
1783 | 4872 | 1624.0 | 128.01 | 42.7 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
1784 | 3248 | 1624.0 | 103.24 | 51.6 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
1785 | 1623 | 1623.0 | 22.82 | 22.8 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
1786 | 1622 | 1622.0 | 52.01 | 52.0 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
1787 | 1621 | 1621.0 | 56.13 | 56.1 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
1788 | 1621 | 1621.0 | 39.56 | 39.6 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
1789 | 1620 | 1620.0 | 46.32 | 46.3 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
1790 | 3239 | 1619.5 | 76.76 | 38.4 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
1791 | 1619 | 1619.0 | 27.54 | 27.5 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
1792 | 1619 | 1619.0 | 47.68 | 47.7 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
1793 | 1619 | 1619.0 | 37.08 | 37.1 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
1794 | 19426 | 1618.8 | 789.64 | 65.8 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. | Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm | Genet Med | 2015 | 25741868 | No |
1795 | 3237 | 1618.5 | 96.37 | 48.2 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
1796 | 1618 | 1618.0 | 47.64 | 47.6 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
1797 | 6471 | 1617.8 | 2523.02 | 630.8 | Cancer statistics, 2023. | Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle, Ahmedin Jemal | CA Cancer J Clin | 2023 | 36633525 | Yes |
1798 | 1617 | 1617.0 | 30.2 | 30.2 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
1799 | 1617 | 1617.0 | 36.14 | 36.1 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
1800 | 3233 | 1616.5 | 98.09 | 49.0 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
1801 | 1616 | 1616.0 | 42.75 | 42.8 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
1802 | 1615 | 1615.0 | 30.38 | 30.4 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
1803 | 1614 | 1614.0 | 45.6 | 45.6 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
1804 | 1614 | 1614.0 | 39.38 | 39.4 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
1805 | 1614 | 1614.0 | 44.6 | 44.6 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
1806 | 1614 | 1614.0 | 45.03 | 45.0 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
1807 | 1614 | 1614.0 | 63.65 | 63.6 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | No |
1808 | 1613 | 1613.0 | 33.95 | 34.0 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
1809 | 1613 | 1613.0 | 31.0 | 31.0 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
1810 | 3226 | 1613.0 | 77.01 | 38.5 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
1811 | 1613 | 1613.0 | 75.0 | 75.0 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
1812 | 3224 | 1612.0 | 71.4 | 35.7 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
1813 | 1612 | 1612.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
1814 | 1611 | 1611.0 | 37.47 | 37.5 | Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. | Bei-Fan Zhou | Biomed Environ Sci | 2002 | 12046553 | Yes |
1815 | 1610 | 1610.0 | 80.76 | 80.8 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
1816 | 1609 | 1609.0 | 31.65 | 31.6 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
1817 | 3216 | 1608.0 | 124.74 | 62.4 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
1818 | 3214 | 1607.0 | 62.59 | 31.3 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
1819 | 3214 | 1607.0 | 66.32 | 33.2 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
1820 | 3213 | 1606.5 | 62.1 | 31.1 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
1821 | 3212 | 1606.0 | 100.24 | 50.1 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
1822 | 3210 | 1605.0 | 83.47 | 41.7 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
1823 | 3209 | 1604.5 | 169.02 | 84.5 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
1824 | 1603 | 1603.0 | 36.9 | 36.9 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
1825 | 1602 | 1602.0 | 36.86 | 36.9 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
1826 | 3204 | 1602.0 | 113.45 | 56.7 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
1827 | 1602 | 1602.0 | 39.04 | 39.0 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
1828 | 1602 | 1602.0 | 35.86 | 35.9 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | No |
1829 | 1602 | 1602.0 | 36.42 | 36.4 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
1830 | 3203 | 1601.5 | 94.96 | 47.5 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
1831 | 3203 | 1601.5 | 62.66 | 31.3 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
1832 | 3203 | 1601.5 | 93.1 | 46.5 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
1833 | 3203 | 1601.5 | 131.82 | 65.9 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | No |
1834 | 1601 | 1601.0 | 42.36 | 42.4 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
1835 | 3202 | 1601.0 | 61.78 | 30.9 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
1836 | 4801 | 1600.3 | 172.34 | 57.4 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
1837 | 1600 | 1600.0 | 40.86 | 40.9 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
1838 | 1600 | 1600.0 | 50.87 | 50.9 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
1839 | 1600 | 1600.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
1840 | 1599 | 1599.0 | 34.43 | 34.4 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
1841 | 1599 | 1599.0 | 36.2 | 36.2 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
1842 | 1598 | 1598.0 | 49.04 | 49.0 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
1843 | 1598 | 1598.0 | 45.84 | 45.8 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | No |
1844 | 9588 | 1598.0 | 225.33 | 37.6 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
1845 | 3195 | 1597.5 | 89.33 | 44.7 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
1846 | 1597 | 1597.0 | 31.5 | 31.5 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
1847 | 1597 | 1597.0 | 30.61 | 30.6 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
1848 | 1597 | 1597.0 | 72.44 | 72.4 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
1849 | 3193 | 1596.5 | 117.39 | 58.7 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | No |
1850 | 1596 | 1596.0 | 57.19 | 57.2 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
1851 | 1596 | 1596.0 | 71.1 | 71.1 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
1852 | 3192 | 1596.0 | 67.34 | 33.7 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
1853 | 1595 | 1595.0 | 28.82 | 28.8 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
1854 | 3190 | 1595.0 | 87.86 | 43.9 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
1855 | 1595 | 1595.0 | 36.84 | 36.8 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
1856 | 1595 | 1595.0 | 40.51 | 40.5 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | No |
1857 | 3189 | 1594.5 | 139.82 | 69.9 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
1858 | 4783 | 1594.3 | 237.43 | 79.1 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
1859 | 1594 | 1594.0 | 34.32 | 34.3 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
1860 | 1594 | 1594.0 | 30.53 | 30.5 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
1861 | 9562 | 1593.7 | 269.3 | 44.9 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
1862 | 3187 | 1593.5 | 77.52 | 38.8 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
1863 | 3187 | 1593.5 | 93.96 | 47.0 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
1864 | 1593 | 1593.0 | 39.26 | 39.3 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
1865 | 1593 | 1593.0 | 30.92 | 30.9 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
1866 | 1593 | 1593.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
1867 | 3186 | 1593.0 | 65.19 | 32.6 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
1868 | 4777 | 1592.3 | 130.66 | 43.6 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
1869 | 4776 | 1592.0 | 116.15 | 38.7 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
1870 | 3183 | 1591.5 | 69.09 | 34.5 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
1871 | 1591 | 1591.0 | 38.26 | 38.3 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
1872 | 4770 | 1590.0 | 115.59 | 38.5 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
1873 | 1590 | 1590.0 | 34.47 | 34.5 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
1874 | 1590 | 1590.0 | 60.02 | 60.0 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
1875 | 9538 | 1589.7 | 279.84 | 46.6 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke | Lancet | 2007 | 18064739 | Yes |
1876 | 3179 | 1589.5 | 75.3 | 37.6 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
1877 | 1589 | 1589.0 | 47.76 | 47.8 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
1878 | 1589 | 1589.0 | 35.79 | 35.8 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | No |
1879 | 1589 | 1589.0 | 51.93 | 51.9 | Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2012 | 22801674 | No |
1880 | 1588 | 1588.0 | 110.61 | 110.6 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
1881 | 3175 | 1587.5 | 91.17 | 45.6 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
1882 | 3174 | 1587.0 | 118.27 | 59.1 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
1883 | 1587 | 1587.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
1884 | 3174 | 1587.0 | 91.69 | 45.8 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
1885 | 3172 | 1586.0 | 70.44 | 35.2 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
1886 | 1586 | 1586.0 | 29.84 | 29.8 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
1887 | 3172 | 1586.0 | 98.81 | 49.4 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
1888 | 1584 | 1584.0 | 49.5 | 49.5 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
1889 | 1583 | 1583.0 | 51.65 | 51.6 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
1890 | 1583 | 1583.0 | 20.26 | 20.3 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
1891 | 4748 | 1582.7 | 122.45 | 40.8 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
1892 | 1582 | 1582.0 | 37.34 | 37.3 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
1893 | 6327 | 1581.8 | 154.59 | 38.6 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
1894 | 3163 | 1581.5 | 96.94 | 48.5 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
1895 | 1581 | 1581.0 | 62.28 | 62.3 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
1896 | 3161 | 1580.5 | 152.0 | 76.0 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | No |
1897 | 1580 | 1580.0 | 29.78 | 29.8 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
1898 | 3160 | 1580.0 | 109.25 | 54.6 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
1899 | 3159 | 1579.5 | 207.73 | 103.9 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
1900 | 1578 | 1578.0 | 29.27 | 29.3 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
1901 | 4732 | 1577.3 | 105.68 | 35.2 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M G Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
1902 | 1577 | 1577.0 | 42.72 | 42.7 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
1903 | 1577 | 1577.0 | 33.51 | 33.5 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
1904 | 3154 | 1577.0 | 68.04 | 34.0 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
1905 | 1577 | 1577.0 | 35.95 | 36.0 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
1906 | 3153 | 1576.5 | 82.09 | 41.0 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
1907 | 1576 | 1576.0 | 35.29 | 35.3 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
1908 | 3152 | 1576.0 | 57.71 | 28.9 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
1909 | 3152 | 1576.0 | 67.32 | 33.7 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
1910 | 1575 | 1575.0 | 52.67 | 52.7 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
1911 | 3150 | 1575.0 | 185.35 | 92.7 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
1912 | 1575 | 1575.0 | 37.59 | 37.6 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
1913 | 1575 | 1575.0 | 48.69 | 48.7 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
1914 | 1575 | 1575.0 | 33.43 | 33.4 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
1915 | 3150 | 1575.0 | 95.42 | 47.7 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
1916 | 4722 | 1574.0 | 182.2 | 60.7 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
1917 | 1573 | 1573.0 | 64.66 | 64.7 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
1918 | 1573 | 1573.0 | 26.01 | 26.0 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
1919 | 1573 | 1573.0 | 29.55 | 29.6 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
1920 | 3146 | 1573.0 | 88.91 | 44.5 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
1921 | 1572 | 1572.0 | 41.65 | 41.6 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
1922 | 3143 | 1571.5 | 101.1 | 50.5 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
1923 | 3143 | 1571.5 | 74.05 | 37.0 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
1924 | 3142 | 1571.0 | 66.99 | 33.5 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
1925 | 1571 | 1571.0 | 31.19 | 31.2 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
1926 | 3142 | 1571.0 | 66.76 | 33.4 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
1927 | 1570 | 1570.0 | 44.87 | 44.9 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
1928 | 14125 | 1569.4 | 434.85 | 48.3 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
1929 | 4707 | 1569.0 | 93.11 | 31.0 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
1930 | 1569 | 1569.0 | 27.79 | 27.8 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
1931 | 3138 | 1569.0 | 75.93 | 38.0 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
1932 | 3138 | 1569.0 | 60.46 | 30.2 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
1933 | 1569 | 1569.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
1934 | 3137 | 1568.5 | 78.97 | 39.5 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
1935 | 1568 | 1568.0 | 33.62 | 33.6 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
1936 | 1568 | 1568.0 | 60.23 | 60.2 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
1937 | 1567 | 1567.0 | 59.23 | 59.2 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
1938 | 3134 | 1567.0 | 95.13 | 47.6 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
1939 | 4700 | 1566.7 | 87.59 | 29.2 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
1940 | 3130 | 1565.0 | 107.51 | 53.8 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
1941 | 17214 | 1564.9 | 449.0 | 40.8 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
1942 | 1564 | 1564.0 | 42.15 | 42.1 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
1943 | 3126 | 1563.0 | 80.73 | 40.4 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
1944 | 1562 | 1562.0 | 61.33 | 61.3 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
1945 | 1561 | 1561.0 | 36.37 | 36.4 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
1946 | 1560 | 1560.0 | 31.29 | 31.3 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
1947 | 1560 | 1560.0 | 42.92 | 42.9 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
1948 | 1560 | 1560.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
1949 | 1560 | 1560.0 | 58.79 | 58.8 | Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2014 | 24378917 | No |
1950 | 3118 | 1559.0 | 66.43 | 33.2 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
1951 | 15587 | 1558.7 | 370.91 | 37.1 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
1952 | 1558 | 1558.0 | 45.49 | 45.5 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
1953 | 1558 | 1558.0 | 38.29 | 38.3 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
1954 | 3115 | 1557.5 | 121.35 | 60.7 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
1955 | 1557 | 1557.0 | 77.93 | 77.9 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
1956 | 1557 | 1557.0 | 48.38 | 48.4 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
1957 | 3114 | 1557.0 | 58.49 | 29.2 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
1958 | 1557 | 1557.0 | 43.78 | 43.8 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | No |
1959 | 3114 | 1557.0 | 69.0 | 34.5 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
1960 | 1556 | 1556.0 | 36.22 | 36.2 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
1961 | 1556 | 1556.0 | 65.42 | 65.4 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | No |
1962 | 1555 | 1555.0 | 35.05 | 35.0 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
1963 | 1555 | 1555.0 | 28.62 | 28.6 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
1964 | 3108 | 1554.0 | 93.27 | 46.6 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
1965 | 4661 | 1553.7 | 103.54 | 34.5 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
1966 | 3107 | 1553.5 | 75.61 | 37.8 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
1967 | 4657 | 1552.3 | 155.86 | 52.0 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
1968 | 1552 | 1552.0 | 48.84 | 48.8 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
1969 | 3103 | 1551.5 | 71.69 | 35.8 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
1970 | 3099 | 1549.5 | 61.72 | 30.9 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
1971 | 1549 | 1549.0 | 42.14 | 42.1 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
1972 | 1549 | 1549.0 | 36.9 | 36.9 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
1973 | 3096 | 1548.0 | 79.55 | 39.8 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
1974 | 3096 | 1548.0 | 56.52 | 28.3 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
1975 | 1548 | 1548.0 | 51.57 | 51.6 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
1976 | 7739 | 1547.8 | 152.49 | 30.5 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
1977 | 4643 | 1547.7 | 88.5 | 29.5 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
1978 | 1547 | 1547.0 | 43.76 | 43.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
1979 | 3094 | 1547.0 | 39.95 | 20.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
1980 | 1547 | 1547.0 | 32.21 | 32.2 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
1981 | 3094 | 1547.0 | 104.17 | 52.1 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
1982 | 1546 | 1546.0 | 67.37 | 67.4 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
1983 | 1546 | 1546.0 | 51.26 | 51.3 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
1984 | 3092 | 1546.0 | 76.84 | 38.4 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
1985 | 3090 | 1545.0 | 184.72 | 92.4 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
1986 | 1545 | 1545.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
1987 | 1545 | 1545.0 | 60.9 | 60.9 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | No |
1988 | 4634 | 1544.7 | 130.69 | 43.6 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
1989 | 3089 | 1544.5 | 61.92 | 31.0 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
1990 | 4633 | 1544.3 | 127.33 | 42.4 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
1991 | 3088 | 1544.0 | 63.48 | 31.7 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
1992 | 1544 | 1544.0 | 45.28 | 45.3 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
1993 | 1542 | 1542.0 | 29.98 | 30.0 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
1994 | 1542 | 1542.0 | 43.55 | 43.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
1995 | 1542 | 1542.0 | 42.82 | 42.8 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
1996 | 1542 | 1542.0 | 59.79 | 59.8 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
1997 | 4625 | 1541.7 | 119.16 | 39.7 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
1998 | 1540 | 1540.0 | 53.17 | 53.2 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
1999 | 1540 | 1540.0 | 43.71 | 43.7 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
2000 | 1539 | 1539.0 | 30.77 | 30.8 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
2001 | 1539 | 1539.0 | 32.93 | 32.9 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
2002 | 3077 | 1538.5 | 21.55 | 10.8 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
2003 | 4613 | 1537.7 | 111.95 | 37.3 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
2004 | 3075 | 1537.5 | 73.43 | 36.7 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
2005 | 1537 | 1537.0 | 49.14 | 49.1 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
2006 | 3074 | 1537.0 | 71.39 | 35.7 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
2007 | 4611 | 1537.0 | 117.62 | 39.2 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
2008 | 6148 | 1537.0 | 119.25 | 29.8 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
2009 | 3074 | 1537.0 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
2010 | 3072 | 1536.0 | 62.42 | 31.2 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
2011 | 1536 | 1536.0 | 41.73 | 41.7 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
2012 | 1535 | 1535.0 | 65.86 | 65.9 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | No |
2013 | 3069 | 1534.5 | 80.49 | 40.2 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
2014 | 1534 | 1534.0 | 30.13 | 30.1 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
2015 | 4602 | 1534.0 | 99.09 | 33.0 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
2016 | 9202 | 1533.7 | 282.45 | 47.1 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
2017 | 3067 | 1533.5 | 87.87 | 43.9 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
2018 | 3066 | 1533.0 | 66.48 | 33.2 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
2019 | 1532 | 1532.0 | 45.78 | 45.8 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
2020 | 3064 | 1532.0 | 79.01 | 39.5 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
2021 | 1531 | 1531.0 | 56.48 | 56.5 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
2022 | 1531 | 1531.0 | 37.91 | 37.9 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
2023 | 3062 | 1531.0 | 67.17 | 33.6 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
2024 | 9183 | 1530.5 | 215.16 | 35.9 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
2025 | 3061 | 1530.5 | 197.33 | 98.7 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
2026 | 1530 | 1530.0 | 67.06 | 67.1 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
2027 | 3059 | 1529.5 | 88.94 | 44.5 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
2028 | 1529 | 1529.0 | 47.45 | 47.5 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
2029 | 1529 | 1529.0 | 33.77 | 33.8 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
2030 | 4585 | 1528.3 | 51.84 | 17.3 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
2031 | 1528 | 1528.0 | 33.72 | 33.7 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
2032 | 1528 | 1528.0 | 41.26 | 41.3 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
2033 | 1528 | 1528.0 | 22.23 | 22.2 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
2034 | 1528 | 1528.0 | 46.03 | 46.0 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
2035 | 1528 | 1528.0 | 34.57 | 34.6 | Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). | K M Fox | Lancet | 2003 | 13678872 | Yes |
2036 | 1528 | 1528.0 | 31.37 | 31.4 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
2037 | 1526 | 1526.0 | 34.65 | 34.6 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
2038 | 3052 | 1526.0 | 67.48 | 33.7 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
2039 | 1525 | 1525.0 | 42.36 | 42.4 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
2040 | 3049 | 1524.5 | 70.88 | 35.4 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
2041 | 1524 | 1524.0 | 38.78 | 38.8 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
2042 | 1523 | 1523.0 | 18.69 | 18.7 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
2043 | 1523 | 1523.0 | 50.23 | 50.2 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
2044 | 1522 | 1522.0 | 51.53 | 51.5 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
2045 | 4564 | 1521.3 | 158.06 | 52.7 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
2046 | 1521 | 1521.0 | 45.3 | 45.3 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
2047 | 1521 | 1521.0 | 90.84 | 90.8 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
2048 | 1521 | 1521.0 | 49.84 | 49.8 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
2049 | 3042 | 1521.0 | 88.36 | 44.2 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
2050 | 3041 | 1520.5 | 114.32 | 57.2 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
2051 | 1520 | 1520.0 | 56.03 | 56.0 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
2052 | 1520 | 1520.0 | 48.64 | 48.6 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
2053 | 3039 | 1519.5 | 82.94 | 41.5 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
2054 | 4557 | 1519.0 | 96.13 | 32.0 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
2055 | 1518 | 1518.0 | 38.18 | 38.2 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
2056 | 1518 | 1518.0 | 49.26 | 49.3 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
2057 | 1517 | 1517.0 | 31.66 | 31.7 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
2058 | 1515 | 1515.0 | 37.98 | 38.0 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
2059 | 1515 | 1515.0 | 27.92 | 27.9 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
2060 | 1515 | 1515.0 | 42.65 | 42.6 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
2061 | 1515 | 1515.0 | 32.95 | 33.0 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
2062 | 1514 | 1514.0 | 39.94 | 39.9 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
2063 | 1514 | 1514.0 | 50.23 | 50.2 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
2064 | 4542 | 1514.0 | 120.57 | 40.2 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
2065 | 4541 | 1513.7 | 222.28 | 74.1 | Shedding light on the cell biology of extracellular vesicles. | Guillaume van Niel, Gisela D'Angelo, Graça Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | No |
2066 | 1513 | 1513.0 | 44.08 | 44.1 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
2067 | 1513 | 1513.0 | 48.48 | 48.5 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
2068 | 1513 | 1513.0 | 48.24 | 48.2 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
2069 | 1510 | 1510.0 | 33.55 | 33.5 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
2070 | 1509 | 1509.0 | 37.13 | 37.1 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
2071 | 3016 | 1508.0 | 76.67 | 38.3 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
2072 | 3016 | 1508.0 | 62.04 | 31.0 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
2073 | 1506 | 1506.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
2074 | 3011 | 1505.5 | 58.95 | 29.5 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
2075 | 19558 | 1504.5 | 506.11 | 38.9 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
2076 | 3009 | 1504.5 | 115.34 | 57.7 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | No |
2077 | 1504 | 1504.0 | 32.95 | 33.0 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
2078 | 3007 | 1503.5 | 101.64 | 50.8 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
2079 | 4509 | 1503.0 | 162.38 | 54.1 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
2080 | 1503 | 1503.0 | 31.63 | 31.6 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
2081 | 3005 | 1502.5 | 87.84 | 43.9 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
2082 | 1502 | 1502.0 | 43.87 | 43.9 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
2083 | 1501 | 1501.0 | 40.8 | 40.8 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
2084 | 1501 | 1501.0 | 36.51 | 36.5 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
2085 | 3001 | 1500.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
2086 | 1500 | 1500.0 | 59.39 | 59.4 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
2087 | 3000 | 1500.0 | 60.09 | 30.0 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
2088 | 1500 | 1500.0 | 32.58 | 32.6 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
2089 | 1500 | 1500.0 | 25.41 | 25.4 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
2090 | 3000 | 1500.0 | 88.59 | 44.3 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
2091 | 2999 | 1499.5 | 66.36 | 33.2 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
2092 | 1499 | 1499.0 | 26.4 | 26.4 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
2093 | 1499 | 1499.0 | 42.47 | 42.5 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
2094 | 1498 | 1498.0 | 52.16 | 52.2 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
2095 | 1498 | 1498.0 | 35.58 | 35.6 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
2096 | 1497 | 1497.0 | 55.17 | 55.2 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
2097 | 1497 | 1497.0 | 33.6 | 33.6 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
2098 | 1497 | 1497.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
2099 | 1496 | 1496.0 | 47.95 | 48.0 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
2100 | 2992 | 1496.0 | 64.2 | 32.1 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
2101 | 2992 | 1496.0 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
2102 | 10468 | 1495.4 | 222.68 | 31.8 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
2103 | 1495 | 1495.0 | 60.3 | 60.3 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
2104 | 1494 | 1494.0 | 70.82 | 70.8 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
2105 | 1493 | 1493.0 | 77.01 | 77.0 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
2106 | 1493 | 1493.0 | 26.13 | 26.1 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
2107 | 1493 | 1493.0 | 36.97 | 37.0 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
2108 | 1492 | 1492.0 | 33.07 | 33.1 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
2109 | 1492 | 1492.0 | 46.53 | 46.5 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
2110 | 4476 | 1492.0 | 129.49 | 43.2 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallières, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
2111 | 4475 | 1491.7 | 111.69 | 37.2 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
2112 | 5965 | 1491.2 | 130.04 | 32.5 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
2113 | 13416 | 1490.7 | 621.98 | 69.1 | Cancer statistics in China, 2015. | Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He | CA Cancer J Clin | 2016 | 26808342 | Yes |
2114 | 2980 | 1490.0 | 56.92 | 28.5 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
2115 | 1489 | 1489.0 | 43.13 | 43.1 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
2116 | 2974 | 1487.0 | 74.74 | 37.4 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
2117 | 1486 | 1486.0 | 34.19 | 34.2 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
2118 | 1486 | 1486.0 | 39.12 | 39.1 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
2119 | 1486 | 1486.0 | 36.84 | 36.8 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
2120 | 2970 | 1485.0 | 87.4 | 43.7 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
2121 | 1485 | 1485.0 | 31.65 | 31.6 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
2122 | 4453 | 1484.3 | 93.59 | 31.2 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
2123 | 2968 | 1484.0 | 89.01 | 44.5 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
2124 | 1483 | 1483.0 | 33.24 | 33.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
2125 | 1482 | 1482.0 | 27.35 | 27.4 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
2126 | 1482 | 1482.0 | 7.91 | 7.9 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
2127 | 2964 | 1482.0 | 98.91 | 49.5 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
2128 | 1481 | 1481.0 | 18.45 | 18.4 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
2129 | 2961 | 1480.5 | 106.79 | 53.4 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
2130 | 4441 | 1480.3 | 45.76 | 15.3 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
2131 | 1480 | 1480.0 | 36.51 | 36.5 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
2132 | 1480 | 1480.0 | 19.72 | 19.7 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
2133 | 1480 | 1480.0 | 40.27 | 40.3 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
2134 | 4440 | 1480.0 | 79.05 | 26.3 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
2135 | 1480 | 1480.0 | 33.86 | 33.9 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
2136 | 8878 | 1479.7 | 258.74 | 43.1 | Cancer statistics, 2009. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2009 | 19474385 | Yes |
2137 | 4438 | 1479.3 | 134.96 | 45.0 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
2138 | 1479 | 1479.0 | 36.79 | 36.8 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
2139 | 1479 | 1479.0 | 39.49 | 39.5 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
2140 | 1478 | 1478.0 | 45.69 | 45.7 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
2141 | 1478 | 1478.0 | 30.69 | 30.7 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
2142 | 1478 | 1478.0 | 45.84 | 45.8 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
2143 | 5910 | 1477.5 | 246.7 | 61.7 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
2144 | 1477 | 1477.0 | 43.13 | 43.1 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
2145 | 1476 | 1476.0 | 33.77 | 33.8 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
2146 | 1476 | 1476.0 | 45.25 | 45.2 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
2147 | 2951 | 1475.5 | 120.1 | 60.0 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
2148 | 4426 | 1475.3 | 86.36 | 28.8 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
2149 | 1475 | 1475.0 | 36.23 | 36.2 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
2150 | 1475 | 1475.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
2151 | 1474 | 1474.0 | 94.96 | 95.0 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
2152 | 1474 | 1474.0 | 12.89 | 12.9 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
2153 | 1474 | 1474.0 | 38.32 | 38.3 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
2154 | 1474 | 1474.0 | 52.47 | 52.5 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
2155 | 1473 | 1473.0 | 19.62 | 19.6 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
2156 | 2946 | 1473.0 | 74.3 | 37.1 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
2157 | 1473 | 1473.0 | 10.68 | 10.7 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
2158 | 2945 | 1472.5 | 76.44 | 38.2 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
2159 | 1472 | 1472.0 | 34.19 | 34.2 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
2160 | 2943 | 1471.5 | 78.0 | 39.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
2161 | 2942 | 1471.0 | 91.85 | 45.9 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
2162 | 1471 | 1471.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
2163 | 13235 | 1470.6 | 407.38 | 45.3 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
2164 | 7351 | 1470.2 | 326.58 | 65.3 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
2165 | 1470 | 1470.0 | 60.42 | 60.4 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | No |
2166 | 1469 | 1469.0 | 40.13 | 40.1 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
2167 | 5873 | 1468.2 | 213.72 | 53.4 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
2168 | 1468 | 1468.0 | 57.31 | 57.3 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
2169 | 1468 | 1468.0 | 37.2 | 37.2 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
2170 | 2935 | 1467.5 | 41.1 | 20.6 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
2171 | 4402 | 1467.3 | 95.53 | 31.8 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
2172 | 4401 | 1467.0 | 137.25 | 45.8 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
2173 | 1467 | 1467.0 | 35.0 | 35.0 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
2174 | 1466 | 1466.0 | 41.09 | 41.1 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
2175 | 1466 | 1466.0 | 41.74 | 41.7 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
2176 | 2931 | 1465.5 | 77.83 | 38.9 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur Respir J | 2004 | 15219010 | No |
2177 | 2930 | 1465.0 | 94.48 | 47.2 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
2178 | 1465 | 1465.0 | 33.51 | 33.5 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
2179 | 1464 | 1464.0 | 31.81 | 31.8 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
2180 | 1464 | 1464.0 | 31.7 | 31.7 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
2181 | 2927 | 1463.5 | 67.71 | 33.9 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
2182 | 1463 | 1463.0 | 33.82 | 33.8 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
2183 | 1463 | 1463.0 | 38.16 | 38.2 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
2184 | 1462 | 1462.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
2185 | 2922 | 1461.0 | 98.49 | 49.2 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
2186 | 2922 | 1461.0 | 57.9 | 28.9 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
2187 | 1461 | 1461.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
2188 | 2922 | 1461.0 | 73.55 | 36.8 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
2189 | 1461 | 1461.0 | 40.86 | 40.9 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
2190 | 1460 | 1460.0 | 51.41 | 51.4 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
2191 | 1460 | 1460.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
2192 | 1460 | 1460.0 | 64.65 | 64.7 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
2193 | 1459 | 1459.0 | 34.15 | 34.1 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
2194 | 1458 | 1458.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
2195 | 1457 | 1457.0 | 34.33 | 34.3 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
2196 | 1457 | 1457.0 | 29.74 | 29.7 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
2197 | 1457 | 1457.0 | 35.61 | 35.6 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
2198 | 1457 | 1457.0 | 43.81 | 43.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
2199 | 1457 | 1457.0 | 32.89 | 32.9 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
2200 | 1457 | 1457.0 | 64.52 | 64.5 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | No |
2201 | 5824 | 1456.0 | 147.62 | 36.9 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
2202 | 1456 | 1456.0 | 40.76 | 40.8 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
2203 | 2911 | 1455.5 | 75.06 | 37.5 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
2204 | 2911 | 1455.5 | 60.33 | 30.2 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
2205 | 11643 | 1455.4 | 289.32 | 36.2 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
2206 | 1455 | 1455.0 | 39.04 | 39.0 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
2207 | 2909 | 1454.5 | 87.42 | 43.7 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
2208 | 2908 | 1454.0 | 99.53 | 49.8 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
2209 | 1454 | 1454.0 | 57.61 | 57.6 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
2210 | 1454 | 1454.0 | 47.72 | 47.7 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
2211 | 1454 | 1454.0 | 31.56 | 31.6 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
2212 | 4360 | 1453.3 | 100.78 | 33.6 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
2213 | 5812 | 1453.0 | 158.22 | 39.6 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
2214 | 2905 | 1452.5 | 102.73 | 51.4 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | No |
2215 | 2904 | 1452.0 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
2216 | 2904 | 1452.0 | 73.8 | 36.9 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
2217 | 1450 | 1450.0 | 28.84 | 28.8 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
2218 | 2900 | 1450.0 | 79.53 | 39.8 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
2219 | 2900 | 1450.0 | 57.57 | 28.8 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
2220 | 1450 | 1450.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
2221 | 2899 | 1449.5 | 72.4 | 36.2 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
2222 | 4348 | 1449.3 | 92.65 | 30.9 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
2223 | 1449 | 1449.0 | 33.61 | 33.6 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
2224 | 1449 | 1449.0 | 94.72 | 94.7 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
2225 | 1449 | 1449.0 | 40.0 | 40.0 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
2226 | 1448 | 1448.0 | 48.58 | 48.6 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
2227 | 5790 | 1447.5 | 162.25 | 40.6 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
2228 | 1447 | 1447.0 | 35.49 | 35.5 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
2229 | 2894 | 1447.0 | 94.64 | 47.3 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
2230 | 1447 | 1447.0 | 36.97 | 37.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
2231 | 2894 | 1447.0 | 66.02 | 33.0 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
2232 | 1447 | 1447.0 | 36.18 | 36.2 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
2233 | 2894 | 1447.0 | 62.17 | 31.1 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
2234 | 1446 | 1446.0 | 49.89 | 49.9 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
2235 | 1446 | 1446.0 | 30.3 | 30.3 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
2236 | 1445 | 1445.0 | 42.99 | 43.0 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
2237 | 2890 | 1445.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
2238 | 2886 | 1443.0 | 78.41 | 39.2 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
2239 | 1443 | 1443.0 | 37.8 | 37.8 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
2240 | 2885 | 1442.5 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
2241 | 2883 | 1441.5 | 67.41 | 33.7 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
2242 | 1441 | 1441.0 | 42.15 | 42.1 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
2243 | 1441 | 1441.0 | 21.54 | 21.5 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
2244 | 2882 | 1441.0 | 85.8 | 42.9 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
2245 | 1441 | 1441.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
2246 | 5762 | 1440.5 | 168.58 | 42.1 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
2247 | 1440 | 1440.0 | 48.25 | 48.2 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
2248 | 2880 | 1440.0 | 55.33 | 27.7 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
2249 | 4318 | 1439.3 | 87.02 | 29.0 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
2250 | 1439 | 1439.0 | 37.16 | 37.2 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
2251 | 1439 | 1439.0 | 43.78 | 43.8 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
2252 | 1439 | 1439.0 | 42.67 | 42.7 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
2253 | 4316 | 1438.7 | 147.06 | 49.0 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
2254 | 2877 | 1438.5 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
2255 | 1438 | 1438.0 | 37.52 | 37.5 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
2256 | 1438 | 1438.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
2257 | 2874 | 1437.0 | 53.65 | 26.8 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
2258 | 1437 | 1437.0 | 33.86 | 33.9 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
2259 | 1437 | 1437.0 | 50.02 | 50.0 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
2260 | 1436 | 1436.0 | 36.59 | 36.6 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
2261 | 1436 | 1436.0 | 27.43 | 27.4 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
2262 | 1436 | 1436.0 | 53.84 | 53.8 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
2263 | 8609 | 1434.8 | 282.35 | 47.1 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
2264 | 1434 | 1434.0 | 40.04 | 40.0 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
2265 | 1433 | 1433.0 | 65.21 | 65.2 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
2266 | 7160 | 1432.0 | 154.21 | 30.8 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
2267 | 1432 | 1432.0 | 40.81 | 40.8 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | No |
2268 | 2862 | 1431.0 | 96.06 | 48.0 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
2269 | 1431 | 1431.0 | 60.37 | 60.4 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
2270 | 1431 | 1431.0 | 35.91 | 35.9 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
2271 | 4289 | 1429.7 | 87.64 | 29.2 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
2272 | 2859 | 1429.5 | 70.29 | 35.1 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
2273 | 2858 | 1429.0 | 98.11 | 49.1 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
2274 | 1429 | 1429.0 | 24.75 | 24.8 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
2275 | 1429 | 1429.0 | 39.47 | 39.5 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
2276 | 2854 | 1427.0 | 83.0 | 41.5 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
2277 | 1427 | 1427.0 | 44.52 | 44.5 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
2278 | 1426 | 1426.0 | 43.04 | 43.0 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
2279 | 1426 | 1426.0 | 34.77 | 34.8 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
2280 | 4277 | 1425.7 | 121.59 | 40.5 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
2281 | 2851 | 1425.5 | 86.09 | 43.0 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
2282 | 5702 | 1425.5 | 256.46 | 64.1 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
2283 | 2850 | 1425.0 | 82.18 | 41.1 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
2284 | 2849 | 1424.5 | 90.39 | 45.2 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
2285 | 1424 | 1424.0 | 25.56 | 25.6 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
2286 | 2848 | 1424.0 | 54.89 | 27.4 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
2287 | 4271 | 1423.7 | 107.46 | 35.8 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
2288 | 2846 | 1423.0 | 54.92 | 27.5 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
2289 | 1423 | 1423.0 | 44.13 | 44.1 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
2290 | 1422 | 1422.0 | 40.88 | 40.9 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
2291 | 1422 | 1422.0 | 27.38 | 27.4 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
2292 | 1421 | 1421.0 | 33.26 | 33.3 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
2293 | 1421 | 1421.0 | 33.69 | 33.7 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
2294 | 2841 | 1420.5 | 72.87 | 36.4 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
2295 | 4260 | 1420.0 | 101.16 | 33.7 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
2296 | 8519 | 1419.8 | 217.85 | 36.3 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
2297 | 4259 | 1419.7 | 94.22 | 31.4 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
2298 | 1419 | 1419.0 | 51.18 | 51.2 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
2299 | 2838 | 1419.0 | 148.24 | 74.1 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
2300 | 1419 | 1419.0 | 26.54 | 26.5 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
2301 | 1419 | 1419.0 | 37.64 | 37.6 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
2302 | 1419 | 1419.0 | 36.6 | 36.6 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
2303 | 2836 | 1418.0 | 79.34 | 39.7 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
2304 | 1418 | 1418.0 | 17.12 | 17.1 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
2305 | 2835 | 1417.5 | 83.44 | 41.7 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
2306 | 2835 | 1417.5 | 62.4 | 31.2 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
2307 | 1417 | 1417.0 | 45.01 | 45.0 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
2308 | 2833 | 1416.5 | 89.75 | 44.9 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
2309 | 2831 | 1415.5 | 88.71 | 44.4 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
2310 | 4246 | 1415.3 | 139.76 | 46.6 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
2311 | 1415 | 1415.0 | 35.0 | 35.0 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
2312 | 1415 | 1415.0 | 57.41 | 57.4 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | No |
2313 | 2826 | 1413.0 | 52.31 | 26.2 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
2314 | 4235 | 1411.7 | 148.07 | 49.4 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
2315 | 1411 | 1411.0 | 45.91 | 45.9 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
2316 | 1411 | 1411.0 | 33.95 | 34.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
2317 | 1411 | 1411.0 | 35.59 | 35.6 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
2318 | 4232 | 1410.7 | 154.39 | 51.5 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
2319 | 1409 | 1409.0 | 50.42 | 50.4 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
2320 | 2818 | 1409.0 | 142.38 | 71.2 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
2321 | 7039 | 1407.8 | 265.5 | 53.1 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | No |
2322 | 2814 | 1407.0 | 77.03 | 38.5 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
2323 | 1407 | 1407.0 | 63.18 | 63.2 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
2324 | 2814 | 1407.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
2325 | 2811 | 1405.5 | 69.84 | 34.9 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
2326 | 2810 | 1405.0 | 81.21 | 40.6 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
2327 | 1405 | 1405.0 | 50.68 | 50.7 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
2328 | 1404 | 1404.0 | 32.75 | 32.8 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
2329 | 2808 | 1404.0 | 71.0 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
2330 | 1404 | 1404.0 | 26.18 | 26.2 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
2331 | 1404 | 1404.0 | 34.13 | 34.1 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
2332 | 2807 | 1403.5 | 85.25 | 42.6 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | No |
2333 | 1403 | 1403.0 | 25.22 | 25.2 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
2334 | 2806 | 1403.0 | 69.24 | 34.6 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
2335 | 1402 | 1402.0 | 51.21 | 51.2 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
2336 | 1402 | 1402.0 | 33.29 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
2337 | 2804 | 1402.0 | 83.95 | 42.0 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
2338 | 2804 | 1402.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
2339 | 2804 | 1402.0 | 62.36 | 31.2 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
2340 | 1402 | 1402.0 | 30.54 | 30.5 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
2341 | 1401 | 1401.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
2342 | 2801 | 1400.5 | 42.04 | 21.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
2343 | 1400 | 1400.0 | 31.95 | 31.9 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
2344 | 2800 | 1400.0 | 55.49 | 27.7 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
2345 | 1400 | 1400.0 | 30.66 | 30.7 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
2346 | 1400 | 1400.0 | 40.47 | 40.5 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
2347 | 2799 | 1399.5 | 68.91 | 34.5 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
2348 | 1399 | 1399.0 | 28.84 | 28.8 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
2349 | 1399 | 1399.0 | 30.25 | 30.2 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
2350 | 1399 | 1399.0 | 33.32 | 33.3 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
2351 | 1399 | 1399.0 | 32.37 | 32.4 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
2352 | 1399 | 1399.0 | 123.8 | 123.8 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
2353 | 1398 | 1398.0 | 44.39 | 44.4 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
2354 | 2795 | 1397.5 | 82.39 | 41.2 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
2355 | 2795 | 1397.5 | 61.34 | 30.7 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
2356 | 4190 | 1396.7 | 197.24 | 65.7 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
2357 | 6980 | 1396.0 | 257.59 | 51.5 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
2358 | 1396 | 1396.0 | 29.55 | 29.6 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
2359 | 1396 | 1396.0 | 44.04 | 44.0 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
2360 | 4187 | 1395.7 | 135.53 | 45.2 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
2361 | 2791 | 1395.5 | 74.61 | 37.3 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
2362 | 1395 | 1395.0 | 17.36 | 17.4 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
2363 | 1395 | 1395.0 | 34.29 | 34.3 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
2364 | 1395 | 1395.0 | 26.98 | 27.0 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
2365 | 2789 | 1394.5 | 81.7 | 40.9 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
2366 | 2789 | 1394.5 | 67.43 | 33.7 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
2367 | 1394 | 1394.0 | 49.99 | 50.0 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
2368 | 2788 | 1394.0 | 65.73 | 32.9 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
2369 | 5576 | 1394.0 | 138.17 | 34.5 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
2370 | 2787 | 1393.5 | 70.11 | 35.1 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
2371 | 1393 | 1393.0 | 37.1 | 37.1 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
2372 | 1393 | 1393.0 | 29.48 | 29.5 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
2373 | 2785 | 1392.5 | 89.45 | 44.7 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
2374 | 1392 | 1392.0 | 29.94 | 29.9 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
2375 | 4176 | 1392.0 | 83.97 | 28.0 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
2376 | 4174 | 1391.3 | 87.55 | 29.2 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
2377 | 4174 | 1391.3 | 98.95 | 33.0 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
2378 | 2781 | 1390.5 | 108.21 | 54.1 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
2379 | 2780 | 1390.0 | 91.87 | 45.9 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
2380 | 1390 | 1390.0 | 24.28 | 24.3 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
2381 | 1389 | 1389.0 | 52.8 | 52.8 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
2382 | 2778 | 1389.0 | 80.26 | 40.1 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
2383 | 5554 | 1388.5 | 270.56 | 67.6 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
2384 | 4165 | 1388.3 | 110.98 | 37.0 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
2385 | 1388 | 1388.0 | 53.61 | 53.6 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
2386 | 2774 | 1387.0 | 100.85 | 50.4 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
2387 | 1387 | 1387.0 | 57.52 | 57.5 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | No |
2388 | 6927 | 1385.4 | 200.79 | 40.2 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
2389 | 2770 | 1385.0 | 71.45 | 35.7 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
2390 | 1385 | 1385.0 | 52.19 | 52.2 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
2391 | 1384 | 1384.0 | 30.74 | 30.7 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
2392 | 2766 | 1383.0 | 95.39 | 47.7 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
2393 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
2394 | 2763 | 1381.5 | 63.14 | 31.6 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
2395 | 2763 | 1381.5 | 61.31 | 30.7 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
2396 | 1381 | 1381.0 | 32.32 | 32.3 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
2397 | 1381 | 1381.0 | 35.29 | 35.3 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
2398 | 6903 | 1380.6 | 167.56 | 33.5 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins | Lancet | 2002 | 12493255 | Yes |
2399 | 2760 | 1380.0 | 94.19 | 47.1 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
2400 | 2760 | 1380.0 | 36.73 | 18.4 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
2401 | 1379 | 1379.0 | 42.89 | 42.9 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
2402 | 2758 | 1379.0 | 63.59 | 31.8 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | No |
2403 | 1379 | 1379.0 | 31.03 | 31.0 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
2404 | 1379 | 1379.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
2405 | 2758 | 1379.0 | 65.66 | 32.8 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
2406 | 5515 | 1378.8 | 208.09 | 52.0 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
2407 | 2753 | 1376.5 | 73.93 | 37.0 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
2408 | 1376 | 1376.0 | 59.61 | 59.6 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
2409 | 2752 | 1376.0 | 58.08 | 29.0 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
2410 | 2752 | 1376.0 | 110.1 | 55.0 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | No |
2411 | 1376 | 1376.0 | 48.27 | 48.3 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | No |
2412 | 4127 | 1375.7 | 91.59 | 30.5 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
2413 | 2750 | 1375.0 | 76.9 | 38.5 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
2414 | 2749 | 1374.5 | 70.39 | 35.2 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
2415 | 1374 | 1374.0 | 29.96 | 30.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
2416 | 4121 | 1373.7 | 100.43 | 33.5 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
2417 | 1373 | 1373.0 | 21.42 | 21.4 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
2418 | 1373 | 1373.0 | 22.33 | 22.3 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
2419 | 1373 | 1373.0 | 31.56 | 31.6 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
2420 | 1373 | 1373.0 | 63.66 | 63.7 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | No |
2421 | 1372 | 1372.0 | 39.09 | 39.1 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
2422 | 1372 | 1372.0 | 36.54 | 36.5 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
2423 | 1372 | 1372.0 | 56.53 | 56.5 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | No |
2424 | 4115 | 1371.7 | 141.96 | 47.3 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graça Raposo, Clotilde Théry | Annu Rev Cell Dev Biol | 2014 | 25288114 | No |
2425 | 2743 | 1371.5 | 77.22 | 38.6 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
2426 | 1371 | 1371.0 | 25.74 | 25.7 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
2427 | 9597 | 1371.0 | 238.8 | 34.1 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
2428 | 9596 | 1370.9 | 387.81 | 55.4 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
2429 | 2741 | 1370.5 | 54.96 | 27.5 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
2430 | 2740 | 1370.0 | 68.19 | 34.1 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
2431 | 2740 | 1370.0 | 84.4 | 42.2 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | No |
2432 | 2739 | 1369.5 | 80.58 | 40.3 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
2433 | 2738 | 1369.0 | 85.61 | 42.8 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
2434 | 1368 | 1368.0 | 28.34 | 28.3 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
2435 | 1368 | 1368.0 | 30.04 | 30.0 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
2436 | 1368 | 1368.0 | 37.53 | 37.5 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
2437 | 1368 | 1368.0 | 36.41 | 36.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
2438 | 5472 | 1368.0 | 219.82 | 55.0 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
2439 | 4101 | 1367.0 | 119.48 | 39.8 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
2440 | 1367 | 1367.0 | 27.87 | 27.9 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
2441 | 2734 | 1367.0 | 73.91 | 37.0 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
2442 | 1367 | 1367.0 | 50.84 | 50.8 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
2443 | 4099 | 1366.3 | 116.82 | 38.9 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
2444 | 1366 | 1366.0 | 29.88 | 29.9 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
2445 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
2446 | 1366 | 1366.0 | 71.28 | 71.3 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | No |
2447 | 2731 | 1365.5 | 92.03 | 46.0 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | No |
2448 | 1365 | 1365.0 | 46.84 | 46.8 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
2449 | 1365 | 1365.0 | 42.64 | 42.6 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
2450 | 2730 | 1365.0 | 61.74 | 30.9 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
2451 | 1365 | 1365.0 | 28.5 | 28.5 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
2452 | 2730 | 1365.0 | 80.66 | 40.3 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
2453 | 8188 | 1364.7 | 205.61 | 34.3 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
2454 | 2729 | 1364.5 | 59.33 | 29.7 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
2455 | 1364 | 1364.0 | 31.26 | 31.3 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
2456 | 2728 | 1364.0 | 66.35 | 33.2 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
2457 | 2728 | 1364.0 | 66.3 | 33.1 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
2458 | 1364 | 1364.0 | 40.53 | 40.5 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
2459 | 2728 | 1364.0 | 110.01 | 55.0 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | No |
2460 | 2726 | 1363.0 | 95.95 | 48.0 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
2461 | 2725 | 1362.5 | 53.74 | 26.9 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
2462 | 2725 | 1362.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
2463 | 2724 | 1362.0 | 56.17 | 28.1 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
2464 | 1362 | 1362.0 | 52.3 | 52.3 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
2465 | 1362 | 1362.0 | 24.66 | 24.7 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
2466 | 1361 | 1361.0 | 29.13 | 29.1 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
2467 | 1361 | 1361.0 | 46.33 | 46.3 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
2468 | 1361 | 1361.0 | 29.76 | 29.8 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
2469 | 1361 | 1361.0 | 45.7 | 45.7 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
2470 | 1361 | 1361.0 | 116.28 | 116.3 | The STROBE guidelines. | Sarah Cuschieri | Saudi J Anaesth | 2019 | 30930717 | No |
2471 | 1361 | 1361.0 | 105.75 | 105.8 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
2472 | 2721 | 1360.5 | 76.16 | 38.1 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
2473 | 1360 | 1360.0 | 32.73 | 32.7 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
2474 | 1360 | 1360.0 | 43.03 | 43.0 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
2475 | 1360 | 1360.0 | 24.06 | 24.1 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
2476 | 1360 | 1360.0 | 28.11 | 28.1 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
2477 | 2720 | 1360.0 | 85.57 | 42.8 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
2478 | 1359 | 1359.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
2479 | 2716 | 1358.0 | 125.28 | 62.6 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
2480 | 1358 | 1358.0 | 60.24 | 60.2 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
2481 | 1358 | 1358.0 | 31.75 | 31.8 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
2482 | 1357 | 1357.0 | 43.51 | 43.5 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
2483 | 1356 | 1356.0 | 28.69 | 28.7 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
2484 | 5424 | 1356.0 | 233.72 | 58.4 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
2485 | 2712 | 1356.0 | 64.64 | 32.3 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
2486 | 1355 | 1355.0 | 64.76 | 64.8 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
2487 | 1355 | 1355.0 | 27.45 | 27.4 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
2488 | 1355 | 1355.0 | 34.32 | 34.3 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
2489 | 1355 | 1355.0 | 37.69 | 37.7 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
2490 | 1355 | 1355.0 | 41.81 | 41.8 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
2491 | 2709 | 1354.5 | 55.13 | 27.6 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
2492 | 1353 | 1353.0 | 44.41 | 44.4 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | No |
2493 | 2706 | 1353.0 | 72.15 | 36.1 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
2494 | 2705 | 1352.5 | 106.59 | 53.3 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | No |
2495 | 1352 | 1352.0 | 34.65 | 34.6 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
2496 | 1352 | 1352.0 | 52.44 | 52.4 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
2497 | 2701 | 1350.5 | 62.2 | 31.1 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
2498 | 6751 | 1350.2 | 182.69 | 36.5 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
2499 | 1350 | 1350.0 | 48.32 | 48.3 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
2500 | 1350 | 1350.0 | 56.7 | 56.7 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
2501 | 4049 | 1349.7 | 49.84 | 16.6 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
2502 | 2699 | 1349.5 | 93.68 | 46.8 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
2503 | 6746 | 1349.2 | 355.97 | 71.2 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
2504 | 1349 | 1349.0 | 41.18 | 41.2 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
2505 | 1349 | 1349.0 | 39.9 | 39.9 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
2506 | 1349 | 1349.0 | 20.49 | 20.5 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
2507 | 1349 | 1349.0 | 41.39 | 41.4 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
2508 | 1349 | 1349.0 | 25.82 | 25.8 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
2509 | 1349 | 1349.0 | 11.77 | 11.8 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
2510 | 1348 | 1348.0 | 41.48 | 41.5 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
2511 | 1348 | 1348.0 | 26.83 | 26.8 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
2512 | 1348 | 1348.0 | 25.95 | 25.9 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
2513 | 1347 | 1347.0 | 33.63 | 33.6 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
2514 | 5388 | 1347.0 | 126.72 | 31.7 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
2515 | 5385 | 1346.2 | 123.8 | 30.9 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
2516 | 1346 | 1346.0 | 43.83 | 43.8 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
2517 | 1346 | 1346.0 | 64.37 | 64.4 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
2518 | 1346 | 1346.0 | 35.51 | 35.5 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
2519 | 1345 | 1345.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
2520 | 1345 | 1345.0 | 40.98 | 41.0 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | No |
2521 | 1344 | 1344.0 | 39.82 | 39.8 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
2522 | 1344 | 1344.0 | 73.46 | 73.5 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | No |
2523 | 1344 | 1344.0 | 102.8 | 102.8 | The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020. | The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team | China CDC Wkly | 2020 | 34594836 | Yes |
2524 | 2686 | 1343.0 | 61.25 | 30.6 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
2525 | 1343 | 1343.0 | 30.26 | 30.3 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
2526 | 1343 | 1343.0 | 38.06 | 38.1 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | No |
2527 | 1342 | 1342.0 | 23.03 | 23.0 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
2528 | 1341 | 1341.0 | 25.64 | 25.6 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
2529 | 1341 | 1341.0 | 27.32 | 27.3 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
2530 | 2682 | 1341.0 | 60.05 | 30.0 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
2531 | 4021 | 1340.3 | 88.01 | 29.3 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
2532 | 1340 | 1340.0 | 35.6 | 35.6 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
2533 | 1340 | 1340.0 | 44.85 | 44.9 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
2534 | 1340 | 1340.0 | 30.2 | 30.2 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
2535 | 2679 | 1339.5 | 61.98 | 31.0 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
2536 | 2678 | 1339.0 | 88.91 | 44.5 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
2537 | 1339 | 1339.0 | 35.88 | 35.9 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
2538 | 4017 | 1339.0 | 90.63 | 30.2 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
2539 | 2675 | 1337.5 | 73.16 | 36.6 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
2540 | 2675 | 1337.5 | 64.6 | 32.3 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
2541 | 1337 | 1337.0 | 25.14 | 25.1 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
2542 | 4010 | 1336.7 | 100.47 | 33.5 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
2543 | 5346 | 1336.5 | 117.44 | 29.4 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
2544 | 1336 | 1336.0 | 28.56 | 28.6 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
2545 | 1336 | 1336.0 | 47.12 | 47.1 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
2546 | 2672 | 1336.0 | 67.45 | 33.7 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
2547 | 2671 | 1335.5 | 59.32 | 29.7 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
2548 | 1335 | 1335.0 | 34.89 | 34.9 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
2549 | 1335 | 1335.0 | 41.82 | 41.8 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
2550 | 1335 | 1335.0 | 32.89 | 32.9 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
2551 | 2669 | 1334.5 | 79.85 | 39.9 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
2552 | 1334 | 1334.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
2553 | 1333 | 1333.0 | 48.19 | 48.2 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
2554 | 1333 | 1333.0 | 33.93 | 33.9 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
2555 | 1333 | 1333.0 | 25.68 | 25.7 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
2556 | 1333 | 1333.0 | 33.28 | 33.3 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
2557 | 2666 | 1333.0 | 53.8 | 26.9 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
2558 | 1333 | 1333.0 | 38.66 | 38.7 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
2559 | 1333 | 1333.0 | 28.41 | 28.4 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
2560 | 1332 | 1332.0 | 30.17 | 30.2 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
2561 | 1332 | 1332.0 | 41.78 | 41.8 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
2562 | 2664 | 1332.0 | 63.29 | 31.6 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
2563 | 3993 | 1331.0 | 102.61 | 34.2 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
2564 | 1331 | 1331.0 | 23.4 | 23.4 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
2565 | 2661 | 1330.5 | 71.13 | 35.6 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
2566 | 1330 | 1330.0 | 34.62 | 34.6 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
2567 | 3990 | 1330.0 | 107.13 | 35.7 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
2568 | 2660 | 1330.0 | 61.24 | 30.6 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
2569 | 5317 | 1329.2 | 130.47 | 32.6 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
2570 | 3987 | 1329.0 | 102.92 | 34.3 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
2571 | 7974 | 1329.0 | 263.31 | 43.9 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke | J Clin Epidemiol | 2008 | 18313558 | Yes |
2572 | 2656 | 1328.0 | 76.09 | 38.0 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
2573 | 2654 | 1327.0 | 55.7 | 27.9 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
2574 | 1327 | 1327.0 | 40.92 | 40.9 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | No |
2575 | 5307 | 1326.8 | 190.44 | 47.6 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
2576 | 2653 | 1326.5 | 57.89 | 28.9 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
2577 | 1326 | 1326.0 | 29.95 | 29.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
2578 | 1326 | 1326.0 | 37.64 | 37.6 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
2579 | 3977 | 1325.7 | 134.31 | 44.8 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
2580 | 1325 | 1325.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
2581 | 1325 | 1325.0 | 13.19 | 13.2 | Cellular resistance to infection. | G B Mackaness | J Exp Med | 1962 | 14467923 | Yes |
2582 | 1324 | 1324.0 | 79.93 | 79.9 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
2583 | 1324 | 1324.0 | 23.11 | 23.1 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
2584 | 1324 | 1324.0 | 38.49 | 38.5 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
2585 | 2647 | 1323.5 | 46.6 | 23.3 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
2586 | 1323 | 1323.0 | 50.59 | 50.6 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
2587 | 2646 | 1323.0 | 68.28 | 34.1 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
2588 | 1323 | 1323.0 | 35.58 | 35.6 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
2589 | 1323 | 1323.0 | 32.27 | 32.3 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
2590 | 2645 | 1322.5 | 60.14 | 30.1 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
2591 | 2645 | 1322.5 | 55.9 | 27.9 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
2592 | 2644 | 1322.0 | 100.63 | 50.3 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
2593 | 1322 | 1322.0 | 38.99 | 39.0 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
2594 | 1322 | 1322.0 | 42.67 | 42.7 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
2595 | 2644 | 1322.0 | 58.06 | 29.0 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
2596 | 2643 | 1321.5 | 118.18 | 59.1 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
2597 | 6607 | 1321.4 | 124.4 | 24.9 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
2598 | 2642 | 1321.0 | 49.07 | 24.5 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
2599 | 1321 | 1321.0 | 54.8 | 54.8 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
2600 | 3961 | 1320.3 | 97.41 | 32.5 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
2601 | 3961 | 1320.3 | 80.79 | 26.9 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
2602 | 1319 | 1319.0 | 22.87 | 22.9 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
2603 | 1319 | 1319.0 | 34.97 | 35.0 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
2604 | 1319 | 1319.0 | 27.26 | 27.3 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | No |
2605 | 2637 | 1318.5 | 56.7 | 28.4 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
2606 | 2637 | 1318.5 | 77.74 | 38.9 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
2607 | 3955 | 1318.3 | 111.83 | 37.3 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
2608 | 1318 | 1318.0 | 34.13 | 34.1 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
2609 | 1318 | 1318.0 | 35.2 | 35.2 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
2610 | 1318 | 1318.0 | 39.26 | 39.3 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
2611 | 7907 | 1317.8 | 199.43 | 33.2 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
2612 | 2635 | 1317.5 | 101.13 | 50.6 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
2613 | 3952 | 1317.3 | 93.44 | 31.1 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
2614 | 5269 | 1317.2 | 123.73 | 30.9 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
2615 | 1317 | 1317.0 | 17.08 | 17.1 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
2616 | 1317 | 1317.0 | 31.48 | 31.5 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
2617 | 1317 | 1317.0 | 35.88 | 35.9 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
2618 | 3950 | 1316.7 | 141.02 | 47.0 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
2619 | 3949 | 1316.3 | 83.55 | 27.8 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
2620 | 1316 | 1316.0 | 28.65 | 28.6 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
2621 | 1316 | 1316.0 | 60.83 | 60.8 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | No |
2622 | 1316 | 1316.0 | 41.23 | 41.2 | Function and information content of DNA methylation. | Dirk Schübeler | Nature | 2015 | 25592537 | No |
2623 | 3947 | 1315.7 | 91.21 | 30.4 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
2624 | 1315 | 1315.0 | 33.4 | 33.4 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
2625 | 1315 | 1315.0 | 40.95 | 41.0 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
2626 | 5259 | 1314.8 | 104.39 | 26.1 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
2627 | 1314 | 1314.0 | 42.0 | 42.0 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
2628 | 7881 | 1313.5 | 196.95 | 32.8 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
2629 | 1313 | 1313.0 | 22.39 | 22.4 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
2630 | 1313 | 1313.0 | 44.42 | 44.4 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
2631 | 1313 | 1313.0 | 33.65 | 33.6 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
2632 | 1312 | 1312.0 | 69.49 | 69.5 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
2633 | 1312 | 1312.0 | 42.22 | 42.2 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
2634 | 2624 | 1312.0 | 67.67 | 33.8 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
2635 | 2622 | 1311.0 | 77.05 | 38.5 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
2636 | 1311 | 1311.0 | 37.28 | 37.3 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
2637 | 1311 | 1311.0 | 39.65 | 39.6 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
2638 | 2621 | 1310.5 | 38.18 | 19.1 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
2639 | 1310 | 1310.0 | 34.59 | 34.6 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
2640 | 1310 | 1310.0 | 24.48 | 24.5 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
2641 | 1310 | 1310.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
2642 | 1310 | 1310.0 | 56.86 | 56.9 | Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. | Alice Y Y Cheng | Can J Diabetes | 2013 | 24070926 | No |
2643 | 2619 | 1309.5 | 163.17 | 81.6 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
2644 | 1309 | 1309.0 | 37.27 | 37.3 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
2645 | 2618 | 1309.0 | 40.47 | 20.2 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
2646 | 2618 | 1309.0 | 49.16 | 24.6 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
2647 | 1309 | 1309.0 | 35.75 | 35.8 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
2648 | 1309 | 1309.0 | 33.01 | 33.0 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
2649 | 1309 | 1309.0 | 81.12 | 81.1 | SARS-CoV-2 vaccines in development. | Florian Krammer | Nature | 2020 | 32967006 | No |
2650 | 3926 | 1308.7 | 87.85 | 29.3 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
2651 | 2617 | 1308.5 | 59.44 | 29.7 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
2652 | 5234 | 1308.5 | 114.73 | 28.7 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
2653 | 1308 | 1308.0 | 27.63 | 27.6 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
2654 | 1308 | 1308.0 | 27.68 | 27.7 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
2655 | 1308 | 1308.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
2656 | 3923 | 1307.7 | 91.29 | 30.4 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
2657 | 2614 | 1307.0 | 40.27 | 20.1 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
2658 | 1307 | 1307.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
2659 | 1305 | 1305.0 | 31.87 | 31.9 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
2660 | 1305 | 1305.0 | 32.17 | 32.2 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
2661 | 2610 | 1305.0 | 83.67 | 41.8 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
2662 | 1305 | 1305.0 | 78.39 | 78.4 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | No |
2663 | 1304 | 1304.0 | 30.11 | 30.1 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
2664 | 1304 | 1304.0 | 24.13 | 24.1 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
2665 | 1304 | 1304.0 | 29.8 | 29.8 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
2666 | 1304 | 1304.0 | 103.89 | 103.9 | COVID-19 and African Americans. | Clyde W Yancy | JAMA | 2020 | 32293639 | Yes |
2667 | 6517 | 1303.4 | 159.86 | 32.0 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
2668 | 1303 | 1303.0 | 37.94 | 37.9 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | No |
2669 | 2605 | 1302.5 | 57.87 | 28.9 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
2670 | 2605 | 1302.5 | 60.28 | 30.1 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
2671 | 2604 | 1302.0 | 43.3 | 21.6 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
2672 | 1302 | 1302.0 | 44.57 | 44.6 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
2673 | 1301 | 1301.0 | 44.62 | 44.6 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
2674 | 2602 | 1301.0 | 64.63 | 32.3 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | No |
2675 | 1301 | 1301.0 | 28.41 | 28.4 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
2676 | 2602 | 1301.0 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
2677 | 2600 | 1300.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
2678 | 1300 | 1300.0 | 53.63 | 53.6 | Inflammation, metaflammation and immunometabolic disorders. | Gökhan S Hotamisligil | Nature | 2017 | 28179656 | No |
2679 | 6499 | 1299.8 | 156.16 | 31.2 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
2680 | 1299 | 1299.0 | 27.59 | 27.6 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
2681 | 1299 | 1299.0 | 30.3 | 30.3 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
2682 | 1299 | 1299.0 | 26.99 | 27.0 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
2683 | 1299 | 1299.0 | 47.02 | 47.0 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | No |
2684 | 2597 | 1298.5 | 83.25 | 41.6 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
2685 | 3895 | 1298.3 | 127.24 | 42.4 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
2686 | 1298 | 1298.0 | 35.29 | 35.3 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
2687 | 1298 | 1298.0 | 32.89 | 32.9 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
2688 | 1298 | 1298.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
2689 | 1298 | 1298.0 | 35.72 | 35.7 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | No |
2690 | 2595 | 1297.5 | 69.48 | 34.7 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
2691 | 1297 | 1297.0 | 31.15 | 31.1 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
2692 | 6481 | 1296.2 | 249.83 | 50.0 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
2693 | 1296 | 1296.0 | 30.98 | 31.0 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
2694 | 1296 | 1296.0 | 36.36 | 36.4 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
2695 | 1296 | 1296.0 | 29.56 | 29.6 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
2696 | 1296 | 1296.0 | 34.37 | 34.4 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
2697 | 1296 | 1296.0 | 39.17 | 39.2 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
2698 | 2591 | 1295.5 | 61.67 | 30.8 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
2699 | 5182 | 1295.5 | 185.67 | 46.4 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
2700 | 2590 | 1295.0 | 131.13 | 65.6 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
2701 | 1295 | 1295.0 | 29.54 | 29.5 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
2702 | 2590 | 1295.0 | 67.53 | 33.8 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
2703 | 1295 | 1295.0 | 32.15 | 32.1 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
2704 | 2590 | 1295.0 | 58.97 | 29.5 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
2705 | 2590 | 1295.0 | 87.09 | 43.5 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | No |
2706 | 6470 | 1294.0 | 241.79 | 48.4 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
2707 | 1294 | 1294.0 | 45.73 | 45.7 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
2708 | 1294 | 1294.0 | 23.36 | 23.4 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
2709 | 1294 | 1294.0 | 22.53 | 22.5 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
2710 | 1294 | 1294.0 | 29.24 | 29.2 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
2711 | 1292 | 1292.0 | 42.57 | 42.6 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
2712 | 1292 | 1292.0 | 61.5 | 61.5 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
2713 | 1292 | 1292.0 | 27.07 | 27.1 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
2714 | 2583 | 1291.5 | 55.4 | 27.7 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
2715 | 1291 | 1291.0 | 42.22 | 42.2 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
2716 | 2582 | 1291.0 | 71.25 | 35.6 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
2717 | 1291 | 1291.0 | 24.07 | 24.1 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
2718 | 2581 | 1290.5 | 45.88 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
2719 | 3871 | 1290.3 | 97.18 | 32.4 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
2720 | 1290 | 1290.0 | 26.97 | 27.0 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
2721 | 1290 | 1290.0 | 35.53 | 35.5 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
2722 | 1290 | 1290.0 | 37.24 | 37.2 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
2723 | 2578 | 1289.0 | 98.09 | 49.0 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
2724 | 14179 | 1289.0 | 380.83 | 34.6 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella | JAMA | 2003 | 12748199 | No |
2725 | 1288 | 1288.0 | 43.45 | 43.5 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
2726 | 2576 | 1288.0 | 94.4 | 47.2 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
2727 | 1287 | 1287.0 | 31.71 | 31.7 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
2728 | 2573 | 1286.5 | 88.61 | 44.3 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
2729 | 1286 | 1286.0 | 38.93 | 38.9 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
2730 | 1286 | 1286.0 | 37.06 | 37.1 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
2731 | 1286 | 1286.0 | 10.68 | 10.7 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
2732 | 1286 | 1286.0 | 46.95 | 47.0 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
2733 | 1286 | 1286.0 | 42.84 | 42.8 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | No |
2734 | 2572 | 1286.0 | 63.52 | 31.8 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
2735 | 2572 | 1286.0 | 46.62 | 23.3 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
2736 | 3858 | 1286.0 | 143.23 | 47.7 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | No |
2737 | 14144 | 1285.8 | 362.74 | 33.0 | Frailty in older adults: evidence for a phenotype. | L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie | J Gerontol A Biol Sci Med Sci | 2001 | 11253156 | Yes |
2738 | 2570 | 1285.0 | 89.21 | 44.6 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
2739 | 1285 | 1285.0 | 30.35 | 30.4 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
2740 | 3853 | 1284.3 | 74.2 | 24.7 | Exosomes: composition, biogenesis and function. | Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
2741 | 2568 | 1284.0 | 51.91 | 26.0 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
2742 | 2567 | 1283.5 | 215.46 | 107.7 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
2743 | 1283 | 1283.0 | 61.0 | 61.0 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
2744 | 1283 | 1283.0 | 34.6 | 34.6 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
2745 | 2565 | 1282.5 | 54.68 | 27.3 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
2746 | 2565 | 1282.5 | 248.32 | 124.2 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | No |
2747 | 8974 | 1282.0 | 308.0 | 44.0 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
2748 | 2563 | 1281.5 | 60.74 | 30.4 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
2749 | 3844 | 1281.3 | 171.98 | 57.3 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
2750 | 8969 | 1281.3 | 251.27 | 35.9 | Cancer statistics, 2008. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun | CA Cancer J Clin | 2008 | 18287387 | Yes |
2751 | 1281 | 1281.0 | 21.74 | 21.7 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
2752 | 1281 | 1281.0 | 33.48 | 33.5 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
2753 | 1281 | 1281.0 | 41.17 | 41.2 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | No |
2754 | 1281 | 1281.0 | 36.01 | 36.0 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
2755 | 2561 | 1280.5 | 66.0 | 33.0 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
2756 | 2561 | 1280.5 | 156.67 | 78.3 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
2757 | 2561 | 1280.5 | 52.58 | 26.3 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
2758 | 1280 | 1280.0 | 31.67 | 31.7 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
2759 | 2560 | 1280.0 | 79.29 | 39.6 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
2760 | 2560 | 1280.0 | 98.81 | 49.4 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | No |
2761 | 3839 | 1279.7 | 90.92 | 30.3 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
2762 | 6398 | 1279.6 | 253.93 | 50.8 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
2763 | 2559 | 1279.5 | 81.93 | 41.0 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
2764 | 2559 | 1279.5 | 66.96 | 33.5 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
2765 | 1279 | 1279.0 | 28.96 | 29.0 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
2766 | 1279 | 1279.0 | 56.01 | 56.0 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
2767 | 1279 | 1279.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
2768 | 1279 | 1279.0 | 31.29 | 31.3 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | No |
2769 | 1278 | 1278.0 | 42.43 | 42.4 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
2770 | 2555 | 1277.5 | 61.37 | 30.7 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
2771 | 1277 | 1277.0 | 39.5 | 39.5 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
2772 | 2554 | 1277.0 | 62.71 | 31.4 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
2773 | 1277 | 1277.0 | 32.01 | 32.0 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
2774 | 1276 | 1276.0 | 34.56 | 34.6 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
2775 | 1276 | 1276.0 | 36.22 | 36.2 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
2776 | 2552 | 1276.0 | 88.77 | 44.4 | Nitric oxide synthases: regulation and function. | Ulrich Förstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | No |
2777 | 1275 | 1275.0 | 28.69 | 28.7 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
2778 | 1275 | 1275.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
2779 | 2549 | 1274.5 | 23.61 | 11.8 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
2780 | 2548 | 1274.0 | 49.0 | 24.5 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
2781 | 1274 | 1274.0 | 47.37 | 47.4 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | No |
2782 | 2547 | 1273.5 | 66.0 | 33.0 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
2783 | 5093 | 1273.2 | 188.81 | 47.2 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
2784 | 1273 | 1273.0 | 31.65 | 31.6 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
2785 | 1273 | 1273.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
2786 | 1273 | 1273.0 | 82.22 | 82.2 | Epidemiology of Prostate Cancer. | Prashanth Rawla | World J Oncol | 2019 | 31068988 | No |
2787 | 20363 | 1272.7 | 572.97 | 35.8 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | No |
2788 | 2545 | 1272.5 | 64.23 | 32.1 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
2789 | 2544 | 1272.0 | 76.11 | 38.1 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
2790 | 1272 | 1272.0 | 33.18 | 33.2 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | No |
2791 | 2543 | 1271.5 | 49.03 | 24.5 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
2792 | 3814 | 1271.3 | 112.97 | 37.7 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
2793 | 5085 | 1271.2 | 116.73 | 29.2 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
2794 | 8898 | 1271.1 | 262.77 | 37.5 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
2795 | 3813 | 1271.0 | 103.64 | 34.5 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
2796 | 1271 | 1271.0 | 29.49 | 29.5 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
2797 | 1270 | 1270.0 | 45.28 | 45.3 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
2798 | 1270 | 1270.0 | 25.5 | 25.5 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
2799 | 1270 | 1270.0 | 31.56 | 31.6 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
2800 | 2539 | 1269.5 | 50.44 | 25.2 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
2801 | 3807 | 1269.0 | 112.39 | 37.5 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
2802 | 1269 | 1269.0 | 32.19 | 32.2 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
2803 | 1269 | 1269.0 | 33.97 | 34.0 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
2804 | 1268 | 1268.0 | 32.44 | 32.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
2805 | 1268 | 1268.0 | 30.08 | 30.1 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
2806 | 3803 | 1267.7 | 118.71 | 39.6 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
2807 | 1267 | 1267.0 | 35.19 | 35.2 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
2808 | 2534 | 1267.0 | 66.63 | 33.3 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
2809 | 1267 | 1267.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
2810 | 1267 | 1267.0 | 26.88 | 26.9 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
2811 | 1267 | 1267.0 | 56.05 | 56.0 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
2812 | 1266 | 1266.0 | 28.24 | 28.2 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
2813 | 2532 | 1266.0 | 51.04 | 25.5 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
2814 | 2531 | 1265.5 | 13.33 | 6.7 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
2815 | 2530 | 1265.0 | 56.96 | 28.5 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
2816 | 1265 | 1265.0 | 35.69 | 35.7 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
2817 | 1264 | 1264.0 | 62.97 | 63.0 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
2818 | 2528 | 1264.0 | 44.24 | 22.1 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
2819 | 7581 | 1263.5 | 217.41 | 36.2 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
2820 | 2526 | 1263.0 | 67.38 | 33.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
2821 | 1263 | 1263.0 | 14.07 | 14.1 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
2822 | 2526 | 1263.0 | 88.62 | 44.3 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | No |
2823 | 1262 | 1262.0 | 49.12 | 49.1 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
2824 | 1262 | 1262.0 | 26.71 | 26.7 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
2825 | 2524 | 1262.0 | 56.0 | 28.0 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
2826 | 1262 | 1262.0 | 41.96 | 42.0 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
2827 | 2524 | 1262.0 | 96.04 | 48.0 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
2828 | 2523 | 1261.5 | 63.39 | 31.7 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
2829 | 1261 | 1261.0 | 44.95 | 45.0 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
2830 | 1261 | 1261.0 | 30.41 | 30.4 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
2831 | 1261 | 1261.0 | 25.92 | 25.9 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
2832 | 1261 | 1261.0 | 25.73 | 25.7 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
2833 | 1261 | 1261.0 | 26.74 | 26.7 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
2834 | 2522 | 1261.0 | 49.94 | 25.0 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
2835 | 1261 | 1261.0 | 39.65 | 39.6 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
2836 | 1260 | 1260.0 | 33.88 | 33.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
2837 | 2519 | 1259.5 | 47.15 | 23.6 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
2838 | 3778 | 1259.3 | 89.78 | 29.9 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
2839 | 5036 | 1259.0 | 144.27 | 36.1 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
2840 | 1259 | 1259.0 | 36.09 | 36.1 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
2841 | 1259 | 1259.0 | 30.61 | 30.6 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
2842 | 1259 | 1259.0 | 28.6 | 28.6 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
2843 | 2517 | 1258.5 | 73.16 | 36.6 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
2844 | 2517 | 1258.5 | 48.39 | 24.2 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
2845 | 1258 | 1258.0 | 25.7 | 25.7 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
2846 | 1258 | 1258.0 | 44.54 | 44.5 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
2847 | 2516 | 1258.0 | 48.79 | 24.4 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
2848 | 1258 | 1258.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
2849 | 2516 | 1258.0 | 68.78 | 34.4 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
2850 | 2516 | 1258.0 | 64.28 | 32.1 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
2851 | 2515 | 1257.5 | 76.67 | 38.3 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
2852 | 5028 | 1257.0 | 283.51 | 70.9 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
2853 | 2514 | 1257.0 | 61.67 | 30.8 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
2854 | 1257 | 1257.0 | 42.83 | 42.8 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
2855 | 1257 | 1257.0 | 30.4 | 30.4 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
2856 | 5027 | 1256.8 | 105.06 | 26.3 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
2857 | 1256 | 1256.0 | 45.71 | 45.7 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
2858 | 1256 | 1256.0 | 20.63 | 20.6 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
2859 | 5024 | 1256.0 | 131.38 | 32.8 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
2860 | 1256 | 1256.0 | 59.93 | 59.9 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | No |
2861 | 1255 | 1255.0 | 52.64 | 52.6 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
2862 | 2509 | 1254.5 | 49.68 | 24.8 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
2863 | 3763 | 1254.3 | 184.95 | 61.6 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
2864 | 7526 | 1254.3 | 208.91 | 34.8 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
2865 | 1254 | 1254.0 | 82.88 | 82.9 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
2866 | 1254 | 1254.0 | 31.48 | 31.5 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
2867 | 1254 | 1254.0 | 27.78 | 27.8 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
2868 | 1254 | 1254.0 | 25.97 | 26.0 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
2869 | 13793 | 1253.9 | 327.36 | 29.8 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
2870 | 10029 | 1253.6 | 255.0 | 31.9 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
2871 | 1253 | 1253.0 | 34.48 | 34.5 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
2872 | 1253 | 1253.0 | 32.32 | 32.3 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
2873 | 1253 | 1253.0 | 30.44 | 30.4 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
2874 | 1253 | 1253.0 | 27.02 | 27.0 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
2875 | 1253 | 1253.0 | 32.12 | 32.1 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
2876 | 1253 | 1253.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
2877 | 1253 | 1253.0 | 39.26 | 39.3 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
2878 | 1253 | 1253.0 | 38.39 | 38.4 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
2879 | 2505 | 1252.5 | 56.14 | 28.1 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
2880 | 3757 | 1252.3 | 112.22 | 37.4 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
2881 | 1252 | 1252.0 | 42.19 | 42.2 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
2882 | 1252 | 1252.0 | 24.81 | 24.8 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
2883 | 1252 | 1252.0 | 29.36 | 29.4 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
2884 | 2503 | 1251.5 | 57.81 | 28.9 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
2885 | 2502 | 1251.0 | 66.79 | 33.4 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
2886 | 1251 | 1251.0 | 50.05 | 50.0 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
2887 | 2501 | 1250.5 | 61.5 | 30.8 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
2888 | 3751 | 1250.3 | 103.71 | 34.6 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | No |
2889 | 2500 | 1250.0 | 53.28 | 26.6 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
2890 | 2499 | 1249.5 | 68.79 | 34.4 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
2891 | 3748 | 1249.3 | 87.76 | 29.3 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
2892 | 1249 | 1249.0 | 57.7 | 57.7 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
2893 | 1249 | 1249.0 | 24.54 | 24.5 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
2894 | 4995 | 1248.8 | 159.12 | 39.8 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
2895 | 1248 | 1248.0 | 20.54 | 20.5 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
2896 | 1248 | 1248.0 | 31.71 | 31.7 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
2897 | 2495 | 1247.5 | 62.57 | 31.3 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
2898 | 1247 | 1247.0 | 33.6 | 33.6 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
2899 | 3740 | 1246.7 | 78.17 | 26.1 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
2900 | 2493 | 1246.5 | 91.15 | 45.6 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
2901 | 2493 | 1246.5 | 43.75 | 21.9 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
2902 | 2493 | 1246.5 | 64.45 | 32.2 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
2903 | 1246 | 1246.0 | 38.41 | 38.4 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
2904 | 1246 | 1246.0 | 31.43 | 31.4 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
2905 | 1245 | 1245.0 | 22.64 | 22.6 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
2906 | 2488 | 1244.0 | 63.1 | 31.6 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
2907 | 1244 | 1244.0 | 27.52 | 27.5 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
2908 | 1244 | 1244.0 | 32.54 | 32.5 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
2909 | 1244 | 1244.0 | 35.86 | 35.9 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
2910 | 3732 | 1244.0 | 114.55 | 38.2 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | No |
2911 | 2488 | 1244.0 | 63.09 | 31.5 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
2912 | 1244 | 1244.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
2913 | 1244 | 1244.0 | 29.05 | 29.1 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
2914 | 1244 | 1244.0 | 45.74 | 45.7 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | No |
2915 | 2486 | 1243.0 | 76.68 | 38.3 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
2916 | 2486 | 1243.0 | 47.79 | 23.9 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
2917 | 1243 | 1243.0 | 30.0 | 30.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
2918 | 1243 | 1243.0 | 24.65 | 24.6 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
2919 | 1243 | 1243.0 | 33.0 | 33.0 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
2920 | 1243 | 1243.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
2921 | 1243 | 1243.0 | 55.53 | 55.5 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | No |
2922 | 7454 | 1242.3 | 278.46 | 46.4 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
2923 | 1242 | 1242.0 | 64.56 | 64.6 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
2924 | 1242 | 1242.0 | 42.07 | 42.1 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
2925 | 1242 | 1242.0 | 35.39 | 35.4 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
2926 | 3726 | 1242.0 | 116.91 | 39.0 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
2927 | 1242 | 1242.0 | 67.61 | 67.6 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
2928 | 3725 | 1241.7 | 115.73 | 38.6 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
2929 | 2483 | 1241.5 | 102.92 | 51.5 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
2930 | 1241 | 1241.0 | 29.81 | 29.8 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
2931 | 1241 | 1241.0 | 52.69 | 52.7 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
2932 | 2481 | 1240.5 | 57.44 | 28.7 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
2933 | 2481 | 1240.5 | 216.31 | 108.2 | The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. | Hussin A Rothan, Siddappa N Byrareddy | J Autoimmun | 2020 | 32113704 | No |
2934 | 1240 | 1240.0 | 37.41 | 37.4 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
2935 | 1240 | 1240.0 | 45.52 | 45.5 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
2936 | 2479 | 1239.5 | 63.72 | 31.9 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | No |
2937 | 2478 | 1239.0 | 99.98 | 50.0 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
2938 | 2478 | 1239.0 | 61.32 | 30.7 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
2939 | 1239 | 1239.0 | 24.31 | 24.3 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
2940 | 2476 | 1238.0 | 59.36 | 29.7 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
2941 | 3713 | 1237.7 | 221.6 | 73.9 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
2942 | 2475 | 1237.5 | 53.08 | 26.5 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
2943 | 2475 | 1237.5 | 73.03 | 36.5 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
2944 | 1237 | 1237.0 | 37.22 | 37.2 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
2945 | 1237 | 1237.0 | 32.44 | 32.4 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
2946 | 1237 | 1237.0 | 47.85 | 47.9 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | No |
2947 | 1236 | 1236.0 | 27.48 | 27.5 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
2948 | 1236 | 1236.0 | 30.29 | 30.3 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
2949 | 1236 | 1236.0 | 38.04 | 38.0 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
2950 | 2469 | 1234.5 | 48.25 | 24.1 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
2951 | 4937 | 1234.2 | 130.4 | 32.6 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
2952 | 1234 | 1234.0 | 38.78 | 38.8 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
2953 | 2468 | 1234.0 | 65.8 | 32.9 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
2954 | 2466 | 1233.0 | 68.25 | 34.1 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
2955 | 2466 | 1233.0 | 64.79 | 32.4 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
2956 | 1233 | 1233.0 | 28.7 | 28.7 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | No |
2957 | 1233 | 1233.0 | 74.81 | 74.8 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | No |
2958 | 1232 | 1232.0 | 22.18 | 22.2 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
2959 | 1232 | 1232.0 | 42.39 | 42.4 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
2960 | 1232 | 1232.0 | 26.31 | 26.3 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
2961 | 1232 | 1232.0 | 24.53 | 24.5 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
2962 | 2463 | 1231.5 | 39.52 | 19.8 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
2963 | 1231 | 1231.0 | 22.59 | 22.6 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
2964 | 1231 | 1231.0 | 33.86 | 33.9 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
2965 | 4924 | 1231.0 | 135.54 | 33.9 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
2966 | 1230 | 1230.0 | 44.29 | 44.3 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
2967 | 6150 | 1230.0 | 192.43 | 38.5 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
2968 | 1230 | 1230.0 | 28.0 | 28.0 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
2969 | 1230 | 1230.0 | 32.01 | 32.0 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
2970 | 2459 | 1229.5 | 65.75 | 32.9 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
2971 | 1229 | 1229.0 | 55.41 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
2972 | 11056 | 1228.4 | 280.52 | 31.2 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
2973 | 1228 | 1228.0 | 49.19 |