Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3577 papers with ECcit ≥ 1014.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 23, July 2022

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1222460222460.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2169675169675.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328427071067.50.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
410363851819.02639.451319.7Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54373443734.01433.251433.2A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63457434574.01119.81119.8Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76512332561.51969.98985.0Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83020130201.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92613026130.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102588825888.0590.68590.7MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112421524215.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
122305923059.0722.98723.0Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
132299722997.0563.42563.4MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
142232022320.0525.04525.0A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
156553221844.00.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
166207420691.30.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
172004020040.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
181908719087.0673.18673.2Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
193768718843.51168.79584.4The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
201854618546.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
213554017770.01216.89608.4Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
225324917749.70.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
233381016905.01628.93814.5Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
241680516805.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
251636416364.0421.61421.6Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
261619216192.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
271590915909.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
281589915899.0593.53593.5A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
293103015515.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
303026215131.00.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
314395814652.71266.13422.0CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
321450214502.0425.51425.5Projector augmented-wave method. BlöchlPhys Rev B Condens Matter19949976227Yes
331414014140.0379.08379.1MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
344073413578.00.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
351353113531.0568.74568.7A power primer. J CohenPsychol Bull199219565683Yes
362682213411.01030.85515.4Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
372652113260.51095.34547.7The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
381319413194.0649.78649.8RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
391271312713.0502.54502.5Catalase in vitro. H AebiMethods Enzymol19846727660Yes
401261712617.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
413718612395.31145.6381.9Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys Rev Lett199610062328Yes
422312311561.5628.28314.1Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
435758011516.01663.8332.8Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
443381011270.01227.59409.2Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys Rev B Condens Matter19889944570Yes
452250511252.5946.15473.1The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
462237011185.0484.78242.4Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
472205511027.5779.27389.6Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
482156310781.5560.06280.0A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
491077410774.0361.97362.0Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
501073310733.0379.23379.2Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
511050410504.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
522074610373.0462.9231.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
531034910349.0288.85288.9Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
541033510335.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
551033110331.0316.77316.8The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
561020910209.0382.54382.5Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
571011310113.0627.02627.0Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
581002210022.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
59197809890.00.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
6096819681.0378.12378.1A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
61190529526.0533.32266.7Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
62189129456.0544.93272.5Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys Rev B Condens Matter19969984901Yes
6394519451.0321.65321.6Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
64185209260.0831.39415.7The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
6592569256.0269.47269.5Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
66183719185.5481.84240.9A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
6791669166.0243.69243.7Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
6890989098.0260.57260.6The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
6989858985.0235.83235.8Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
7088448844.0252.98253.0Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7188408840.0191.9191.9Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
7287898789.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
73261588719.3696.04232.0VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
7487038703.0235.98236.0RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
75259818660.31096.08365.4Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
7685988598.0263.43263.4Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
77341478536.81016.08254.0Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
78339048476.01413.37353.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
79168618430.5365.48182.7The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
8083418341.0175.68175.7Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
8182288228.0366.42366.4Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8281218121.0231.67231.7Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8380338033.0175.92175.9The functions of animal microRNAs. Victor AmbrosNature200415372042No
8480098009.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
8578967896.0300.18300.2Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
86314287857.01200.26300.1A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
8778337833.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
8878237823.0210.03210.0Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
89234527817.3876.44292.1NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
9077877787.0218.35218.3The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
9177787778.0218.55218.6"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
92155157757.5359.8179.9Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
93232617753.7639.44213.1Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9477227722.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
9575807580.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
9675297529.0245.73245.7The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
97296347408.5980.58245.1Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
98221597386.31003.76334.6Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
99147677383.5643.72321.9MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
100147227361.0410.75205.4Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
10173327332.0334.0334.0Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
10273137313.0199.68199.7Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
10372757275.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
10472737273.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
105145417270.5364.46182.2MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
10672217221.0183.42183.4PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
10772207220.0217.83217.8AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
108143337166.5316.63158.3KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
10970697069.0240.3240.3Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys Rev B Condens Matter19869938299Yes
110492597037.01291.76184.5Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
11170177017.0193.06193.1TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
112210507016.70.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
11369876987.0329.57329.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11469666966.0157.24157.2Chromatin modifications and their function. Tony KouzaridesCell200717320507No
11569526952.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
11669216921.0187.07187.1Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
117136946847.0314.84157.4Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11868106810.0189.16189.2Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
11967976797.0184.69184.7The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
120135676783.50.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
121135456772.5289.32144.7 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
12267376737.0172.12172.1Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12367156715.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
12466866686.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
125198266608.71376.59458.9MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
126196776559.0560.18186.7A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
12765256525.0172.57172.6Adhesion receptors of the immune system. T A SpringerNature19901974032No
128389916498.53699.71616.6Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
12964796479.0198.95198.9The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
13064396439.0169.37169.4Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
131128226411.00.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
13263666366.0130.37130.4Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
133127316365.50.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
13463116311.0209.26209.3Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
13562786278.0205.67205.7The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
13662166216.0135.46135.5p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
13761656165.0325.53325.5Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
13861376137.0297.63297.6UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
139122106105.00.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
14061006100.0125.3125.3Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
141121286064.00.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
14260496049.0150.17150.2Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
143240026000.50.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
14459825982.0152.76152.8Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
14559675967.0134.94134.9Inflammation in atherosclerosis. Peter LibbyNature200212490960No
146178545951.3569.58189.9Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
14759465946.0152.42152.4G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
148178335944.3513.72171.2edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
14959425942.0146.8146.8Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
150118705935.00.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
151116795839.5411.64205.8The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15258065806.0141.34141.3Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
15357885788.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15457865786.0207.97208.0The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
15557445744.0138.93138.9Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
156172055735.0526.81175.6The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
15756755675.0144.25144.2Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
158113345667.0403.86201.9Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
15956675667.0340.0340.0SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
160113325666.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
161169045634.70.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
162112275613.5278.6139.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
16355715571.0108.26108.3BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
164111115555.5300.24150.1Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
165110775538.5252.45126.2Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
16655135513.0131.85131.8Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
167109585479.0368.52184.3AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
168109375468.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
16954625462.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
17054175417.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
17154065406.0127.05127.0Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
172107545377.0253.01126.5Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17353625362.0119.62119.6The biochemistry of apoptosis. M O HengartnerNature200011048727No
17453605360.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
17553565356.0136.03136.0Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
17653485348.0136.74136.7New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
17753035303.0141.07141.1The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
178159015300.3480.85160.3A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
17952935293.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
180105855292.5272.55136.3BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
18152755275.0147.67147.7A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
182105415270.5252.99126.5A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
18352705270.0153.7153.7Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
184105365268.0300.35150.2MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
18552525252.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18652505250.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
187104975248.5237.26118.6One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18852385238.0176.0176.0jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18952215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
190208495212.2718.05179.5G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
19151905190.0210.48210.5Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
19251905190.0127.04127.0The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
19351815181.0190.42190.4Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
194258835176.6706.35141.3The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
19551665166.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
19651615161.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
197103155157.5289.78144.9Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
198102205110.0293.07146.5EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
199101785089.0373.22186.6The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
200101015050.5269.44134.7Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
20150355035.0186.32186.3Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
20250015001.0100.84100.8Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
20349974997.0102.35102.3Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
20449934993.0150.67150.7Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
20549884988.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
206148474949.0540.76180.3Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
20749294929.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
20898554927.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
20998034901.5357.07178.5Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
21048714871.0144.03144.0A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
21148634863.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
21297114855.5214.25107.1Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
213145424847.3395.36131.8Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
214144734824.3361.03120.3A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
21548124812.0120.48120.5Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
21696224811.0233.2116.6Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
21748074807.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
21847994799.097.7397.7An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
21995834791.50.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
22047884788.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
22147724772.0109.99110.0MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
222143024767.3547.62182.5The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
223142164738.70.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
22494754737.50.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
22594674733.5231.48115.7A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
22694274713.5212.19106.1The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
22747074707.0182.72182.7An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
22846914691.0107.11107.1ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
22993624681.0237.87118.9Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
23046754675.0158.65158.7The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
23146734673.0104.49104.5Cancer cell cycles. C J SherrScience19968939849No
23246624662.0130.07130.1Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
23346614661.098.3998.4Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23446494649.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
235138894629.7485.18161.7Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
23646284628.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
237230974619.41132.6226.5MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
23846154615.0127.72127.7Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
239184424610.5558.1139.5MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
240138124604.0349.31116.4Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
24146034603.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
24291564578.0253.24126.6Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
24345364536.088.1288.1DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
244226564531.20.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
245135914530.3303.12101.0Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
24690514525.5304.76152.4Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
24745234523.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
24844994499.0102.25102.2Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
24944864486.098.0598.0ras genes. M BarbacidAnnu Rev Biochem19873304147No
25044614461.0109.62109.6A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
25188984449.00.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
25288824441.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
25344374437.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25444364436.0174.2174.2Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
25588684434.0201.56100.8Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
25644284428.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
25744284428.0101.61101.6Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
25888264413.00.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
25944084408.0129.93129.9How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
26088154407.5253.64126.8The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
26144004400.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
26287874393.50.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
26343844384.090.2790.3Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
26486934346.5265.16132.6RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
26543454345.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
26643264326.0113.25113.2Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
26786424321.0241.35120.7Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
26886414320.51656.14828.1Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
269259114318.5984.1164.0Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
27043144314.0101.91101.9Cancer. p53, guardian of the genome. D P LaneNature19921614522No
27186004300.00.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
272171724293.00.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
27342904290.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
27485654282.5233.1116.5A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
27542724272.0113.94113.9The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
27685404270.00.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
27742474247.094.0694.1Apoptosis by death factor. S NagataCell19979039262No
27842414241.090.9591.0Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
27942354235.0113.14113.1Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
28042224222.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
28184314215.5198.0199.0SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
28242124212.094.7794.8Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
28342084208.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
28441994199.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
28541954195.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
286251634193.81007.73168.0MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
28783864193.0196.3998.2MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
28841854185.099.9399.9Mechanisms of angiogenesis. W RisauNature19979109485No
28941574157.087.6687.7The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
29041574157.081.8181.8The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
29141384138.0126.09126.1Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
29241324132.087.4387.4Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
29382574128.5179.389.7Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
29441084108.088.6188.6Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
29582064103.00.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
29641024102.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
29740904090.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
29840904090.075.7575.8Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
299121934064.3746.13248.7Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30040584058.093.6793.7Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
30181054052.50.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
30240514051.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
30340464046.0139.59139.6Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
30440314031.0132.15132.2Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
30540144014.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
30680234011.5199.4199.7WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
30740034003.0126.75126.8Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
30879993999.5195.9498.0Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
30939973997.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
310159483987.0447.8112.0Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
31139813981.0103.9103.9Integrins: a family of cell surface receptors. R O HynesCell19873028640No
312119423980.71357.72452.6Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
31339653965.0147.19147.2EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31439473947.087.9387.9Atherosclerosis. A J LusisNature200011001066No
31578813940.5304.83152.4Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
31639383938.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
31739363936.0129.07129.1Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
31839363936.088.7988.8PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
31939353935.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
32078563928.00.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
32178263913.0230.19115.1Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
32239043904.096.7996.8Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
32339033903.0107.45107.5What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
32438863886.0120.63120.6Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
32538823882.0126.59126.6Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
326116373879.0520.2173.4Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
32777543877.00.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
328232423873.7775.73129.3Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32977303865.0277.7138.8Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
33038633863.082.7582.8The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
33138623862.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
33276973848.5219.94110.0Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys Rev B Condens Matter199310004490Yes
33338373837.0102.71102.7Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33438323832.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
33537883788.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
33675723786.0144.2272.1A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
337113463782.00.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
33837813781.080.8780.9A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
33937813781.0104.08104.1Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
34037763776.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
341113073769.0957.83319.3Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
342113013767.0773.97258.0Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
34337623762.093.4393.4Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
344112783759.30.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
34537593759.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
34674863743.0254.42127.2DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
34737403740.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
34837373737.076.7376.7Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
34937343734.0107.94107.9Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
350111843728.0215.7871.9Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
35174463723.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
35237203720.0142.09142.1Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
35337193719.090.2590.2Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
35437093709.083.4983.5Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
35537023702.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
356111003700.0423.41141.1A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
35773933696.5313.59156.8The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
35836963696.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
35973893694.5182.7991.4Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
36036943694.078.1778.2TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
36136813681.088.9889.0Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
36236753675.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
36336743674.0110.19110.2Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys Rev B Condens Matter19909993096Yes
36436683668.077.777.7Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
365146373659.2393.9198.5Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
36672933646.5188.1594.1tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
36736313631.0100.6100.6Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
36836233623.0122.41122.4Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
36936223622.072.7672.8Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
37072423621.00.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
37136143614.085.285.2Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
37236073607.0109.52109.5Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
37336063606.082.8382.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37436043604.066.666.6Somatic generation of antibody diversity. S TonegawaNature19836300689No
37571893594.5272.17136.1The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
37635943594.099.5199.5Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
37735803580.0100.54100.5Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
37835713571.081.3881.4Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
37935533553.0187.25187.2Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
38035443544.0120.31120.3How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
381141683542.0573.09143.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
38270753537.5185.7192.9Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38370733536.5134.0267.0Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
38470623531.0158.5279.3Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
38535283528.084.4784.5Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
38635043504.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
38770053502.5206.91103.5BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
38835013501.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
389104973499.0431.43143.8A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
39034913491.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
39134903490.0103.88103.9What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
39269753487.50.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
39334863486.078.4378.4Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
394174093481.8503.34100.7Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
39534783478.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
39634783478.0116.11116.1genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
39734653465.093.1193.1Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39834603460.071.2571.2Mammalian neural stem cells. F H GageScience200010688783No
39934573457.090.0690.1Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
40034523452.0102.89102.9Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
40134453445.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
40268813440.5164.4282.2"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
403103143438.0389.49129.8Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
404102823427.3337.96112.7Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
40534183418.0133.23133.2A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
40634183418.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
40734033403.089.6589.7Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
40833993399.0103.67103.7Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
40933963396.084.6184.6The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
41033903390.090.3790.4The origins and the future of microfluidics. George M WhitesidesNature200616871203No
411101663388.7436.49145.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
41233883388.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
41333873387.065.9766.0Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
414101443381.30.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
41533793379.090.4990.5The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
41633763376.079.4579.5The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
417134793369.8339.084.8Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
41867323366.0174.3787.2TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
419201583359.71104.79184.1Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
420201463357.7772.09128.7Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
421234993357.0540.8877.3UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
422100563352.01827.62609.2Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
42333503350.086.686.6I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
42466963348.0124.9562.5Translating the histone code. T Jenuwein, C D AllisScience200111498575No
42533413341.077.5477.5Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
42633403340.093.0493.0Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
42733343334.0102.05102.0Graphene: status and prospects. A K GeimScience200919541989Yes
42866573328.5171.8785.9An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
42933273327.069.0469.0Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
43033263326.069.1169.1The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
43133233323.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
43266393319.50.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
43399563318.7396.25132.1Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
43433153315.0132.35132.3Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
43533153315.078.3878.4Glutamate uptake. N C DanboltProg Neurobiol200111369436No
43633153315.078.478.4Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
43733143314.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
43833113311.084.8684.9Gene regulation by steroid hormones. M BeatoCell19892644044No
43933033303.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
44099043301.3525.09175.0Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
44133003300.070.6870.7Profile hidden Markov models. S R EddyBioinformatics19989918945No
44232863286.084.5584.5Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
44398513283.7424.32141.4HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
44465613280.50.00.0Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44565553277.5177.9889.0The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
446130663266.5304.8376.2Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
44732643264.0107.62107.6Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
44865093254.5558.87279.4A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
44932523252.0102.62102.6Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
45032393239.094.5794.6Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
45164743237.0240.71120.4Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
452129413235.2510.76127.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
45332333233.0103.92103.9Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
45432313231.075.5275.5Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
45532303230.072.3772.4Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
45632273227.093.1993.2Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
45764393219.5185.692.8Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
45832063206.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
45964063203.0151.9576.0Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
46063903195.0186.6693.3Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
46131943194.086.486.4ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
46231893189.091.691.6EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
46331843184.079.3779.4The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
46431783178.0130.63130.6FreeSurfer. Bruce FischlNeuroimage201222248573No
46563323166.0131.0565.5Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
46663183159.0124.3662.2The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
46731573157.078.1378.1Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
46831523152.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
46931463146.059.6159.6Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
47031443144.077.3377.3Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
47194323144.0245.1581.7Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
47231343134.081.6181.6The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
47331343134.090.790.7Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
47431333133.065.1465.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
47531323132.063.1463.1STATs and gene regulation. J E DarnellScience19979287210No
47662643132.0138.6569.3Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
47731313131.068.9969.0Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
47862613130.50.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
47931303130.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
48062433121.5156.9678.5The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
48131073107.081.6981.7Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
48231063106.076.6776.7Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
48330983098.075.4475.4Photoelectrochemical cells. M GrätzelNature200111713540Yes
48430983098.079.2979.3How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
48530963096.077.9778.0The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
48630923092.073.4573.5WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
48730913091.085.685.6Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
488123423085.5430.3107.6A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
48930683068.083.9984.0Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
490275663062.9751.2483.5The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
49191803060.0313.45104.5Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
49230463046.062.6162.6The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
49360913045.5147.3273.7Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
49460893044.5163.1581.6Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
49560683034.0224.66112.3Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
49630303030.097.7297.7Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
49730223022.089.9590.0Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
49830143014.070.6870.7Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
49930093009.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
50030013001.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
50129992999.063.9263.9Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
50229932993.065.4165.4Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
50329882988.00.00.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
50429882988.064.9665.0Protein folding and misfolding. Christopher M DobsonNature200314685248No
50559722986.00.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
50629862986.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
50729822982.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
50829822982.092.4792.5Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
509148702974.0596.16119.2The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
51029742974.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
51159472973.5130.9365.5Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
51229702970.065.3765.4Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
51359272963.5125.6162.8Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
51488622954.0192.6364.2Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
51588332944.3179.6859.9Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
51629412941.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
51758812940.5136.9968.5MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
51829392939.0114.54114.5Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
51958672933.5168.3984.2Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52029262926.069.769.7Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
52129232923.091.0491.0Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
52287642921.3243.9681.3Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
52358272913.50.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
52429112911.094.2994.3An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
52529112911.070.7970.8Obesity as a medical problem. P G KopelmanNature200010766250No
52629092909.0133.29133.3The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
52787192906.3233.5677.9Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
52829042904.092.7392.7Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
52929012901.0118.8118.8Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
53057962898.0105.552.8The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
53128912891.063.1463.1Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
532115502887.5458.06114.5APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
53328872887.093.8293.8Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
53457702885.0150.1375.1Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
53557682884.0163.781.8Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
53628812881.091.3991.4Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
53786292876.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
53828752875.055.1355.1RNA interference. Gregory J HannonNature200212110901No
53928732873.071.1471.1Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
54028732873.068.1668.2Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
54128712871.051.4351.4One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
54257362868.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
54328642864.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
544114522863.0281.9570.5Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
54528622862.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
54628612861.099.8399.8The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
54757192859.50.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
54828542854.060.1160.1Principles of CDK regulation. D O MorganNature19957877684No
54928542854.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
55028532853.074.4374.4Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
55185502850.00.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
55228482848.0143.59143.6Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
55356932846.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
55456852842.50.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55528412841.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
55656622831.0140.6770.3In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
55728312831.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
55828302830.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
55956512825.50.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
56056442822.0136.6968.3Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
56128222822.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
56228202820.094.6694.7Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
56356342817.0265.78132.9phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
56484282809.3439.2146.4Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
56556182809.0189.7694.9Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
56628062806.0151.2151.2Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
56728012801.057.5257.5Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
56827992799.085.0585.0Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
56927972797.094.494.4Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
57027942794.0105.83105.8You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
57155872793.5153.5476.8The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
57283652788.3207.6469.2TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
57327862786.079.6479.6Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
57455722786.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
575111392784.80.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
57627842784.072.5272.5Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
57727812781.053.8253.8Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57855622781.0241.08120.5The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
57955592779.5179.5789.8Tissue engineering. R Langer, J P VacantiScience19938493529No
58027772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
58127772777.063.763.7TGFbeta in Cancer. Joan MassaguéCell200818662538No
58255462773.0128.5764.3Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
58355462773.0187.2493.6The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
58427722772.0128.82128.8The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
58555442772.0245.51122.8Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
58627692769.061.3761.4Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
58727632763.066.2866.3Structure and function of telomeres. E H BlackburnNature19911708110No
58855152757.5128.0964.0Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
58955142757.0127.463.7Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
59027542754.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
59127512751.079.0179.0RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
59227482748.089.5789.6No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
59354962748.0109.2654.6High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
59427442744.052.4152.4Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
59582182739.3178.359.4Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
596109302732.5361.2190.3Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
59727322732.066.5266.5Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
59881942731.3273.5591.2Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
59954622731.0177.6588.8mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
60027282728.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
60127242724.064.5464.5Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
60254432721.5200.69100.3FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
60327192719.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
60427182718.084.1784.2Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
60527182718.069.6469.6The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
60654232711.5140.6770.3Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
60727092709.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
60854172708.5155.8677.9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
60954112705.5129.1464.6Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
61054112705.50.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
61181062702.0208.3869.5MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
61227012701.083.1483.1Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
61353862693.0117.3158.7Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
61453832691.5168.8384.4Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
61553722686.0133.2466.6Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
61626842684.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
61726792679.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
61826752675.086.1686.2Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
61953472673.5165.882.9Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
62026732673.060.0460.0Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
62153442672.0167.3883.7Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
62226682668.055.255.2Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
62353352667.5190.1895.1A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
62480012667.0185.3361.8The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62553312665.50.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
626212992662.4477.6859.7The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
62779812660.3235.5678.5Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
62853182659.0109.6254.8Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
62926582658.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
63026522652.046.4746.5Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
63126442644.054.2554.2Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
63226432643.077.4377.4A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
633105432635.8229.6257.4Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
63426332633.053.4653.5The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
63526332633.098.6298.6Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
63626312631.071.4271.4Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
63726282628.060.3460.3Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
63826272627.060.7260.7Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
63952392619.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
64052362618.0192.2196.1Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
64152332616.5174.3587.2Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
64226162616.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64352302615.0107.653.8Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
64452142607.00.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
64526072607.052.2852.3Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
64626062606.082.4982.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
64752122606.0113.556.8Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
64826032603.0120.95121.0Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
64952052602.5183.4691.7A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
65052032601.5176.7888.4Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
65126012601.082.5282.5adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
65226002600.093.3893.4Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
65351982599.0117.4658.7Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
65425972597.065.2265.2The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
65525962596.061.461.4Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
65625922592.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
65751762588.00.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
65825852585.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
65925802580.061.4361.4Memory--a century of consolidation. J L McGaughScience200010634773No
66025762576.081.6381.6Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
66125752575.055.8955.9G1 phase progression: cycling on cue. C J SherrCell19947954821No
66225752575.081.4781.5What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
66325752575.068.3868.4Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
66451422571.00.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
66525712571.094.5394.5What is value in health care? Michael E PorterN Engl J Med201021142528Yes
66625692569.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
66725682568.047.4847.5Wnt signaling and cancer. P PolakisGenes Dev200010921899No
66825682568.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
66925662566.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
67025662566.0100.42100.4The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
67151212560.5130.6865.3Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
67225602560.062.4662.5Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
67325602560.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
67425552555.073.2573.2Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
67525482548.059.2359.2Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
67625462546.066.3666.4The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67750922546.0140.6270.3Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
67825442544.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
67950812540.5147.6173.8Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
68076102536.7183.6161.2Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
68125362536.00.00.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
682101412535.2309.0477.3Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
68350632531.5158.9479.5The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
68425182518.056.1856.2Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
68525172517.077.7177.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
68625142514.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
68750252512.5161.7480.9Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys Rev B Condens Matter199210001404Yes
68825092509.050.8350.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
68925052505.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
69050092504.50.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
69150062503.00.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
69275052501.7147.5149.2Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
69350022501.0203.11101.6A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
69450012500.5238.56119.3GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
69524972497.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
69624972497.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
69749902495.00.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
69849902495.0123.0861.5Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
69924922492.057.1357.1Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
70024812481.060.3660.4MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
70124792479.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
70224772477.072.5172.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
70324752475.058.758.7Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
70424722472.059.1959.2Calcium signaling. David E ClaphamCell200718083096No
70524722472.086.9186.9DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
70624682468.066.8766.9Dominant forces in protein folding. K A DillBiochemistry19902207096No
70748982449.098.9549.5Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
70848912445.50.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
70924452445.058.5158.5Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71048882444.0161.0880.5The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
71148882444.0103.7751.9MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
71224432443.057.3957.4Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
71324412441.055.1955.2Social controls on cell survival and cell death. M C RaffNature19921557121No
71424392439.061.961.9Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
71548762438.0207.17103.6Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
71648642432.0137.3368.7Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
71748602430.00.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
71848592429.5118.1259.1Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
71972852428.3392.04130.7Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
72096982424.5455.61113.9Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
72124242424.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
72272722424.0324.65108.2HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
72348452422.50.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
72424182418.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
72572542418.0269.8990.0featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
72648272413.595.8747.9CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
72724122412.054.8754.9Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
72896322408.0302.7175.7Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
72924042404.065.8865.9Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
73023992399.051.8251.8Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
73123962396.099.4499.4Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
73223952395.064.664.6The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
73347822391.00.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
73423892389.046.7346.7Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
73523832383.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
73623832383.048.6848.7Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
73747642382.0149.374.7Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73823782378.058.3858.4Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
73923702370.00.00.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
74023702370.062.4362.4Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
74123692369.068.4668.5Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
74223672367.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
74323632363.073.873.8SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
74423572357.059.5659.6Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
74523542354.051.7151.7Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
74646962348.00.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
74723432343.0159.09159.1Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
74870272342.3316.03105.3Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
74946802340.096.4748.2Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
75069952331.7184.8461.6ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
75146622331.0163.5581.8The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
75246612330.5231.76115.9Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
75323302330.086.2486.2Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
75423282328.070.7470.7Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
75546472323.50.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
75623232323.053.7153.7A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
75723222322.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
75846352317.5104.5552.3Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
75923162316.052.352.3The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
76046312315.592.3646.2The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
76123132313.058.5758.6Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
762138752312.5329.9855.0Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
76392482312.0317.7979.4A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
76423112311.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
76523052305.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
76646072303.593.2446.6Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
76723022302.082.4582.5A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
76822972297.057.5157.5Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
76922962296.066.2766.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
77022932293.049.049.0Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
77122932293.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
77245862293.0122.8161.4Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
77322932293.066.8266.8The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
77422912291.069.1769.2Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
77568722290.70.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
77622892289.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
77745762288.00.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
77822882288.051.8751.9Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
77922862286.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
78022782278.045.8545.9SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
78122782278.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
78222772277.067.1567.2Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
78345462273.086.6643.3A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
78422732273.049.349.3Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
78522722272.057.1157.1A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
78622662266.060.2260.2A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
78722652265.066.4166.4Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
78822642264.076.3376.3Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
78922602260.066.6366.6Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
79022572257.071.9572.0Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
79145142257.0147.0873.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
79245122256.097.1948.6New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
79345102255.0119.7159.9Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
79445062253.00.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
79522512251.056.0256.0The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
79644962248.0103.1151.6A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
79722472247.042.7742.8Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
798201892243.2447.5949.7Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
79944862243.00.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
80044862243.0115.3157.7Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
80122432243.057.1857.2A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
80244812240.50.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
80322382238.049.8549.9Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
80444752237.5104.8852.4Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
80522372237.066.3666.4Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
80622352235.042.0242.0Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
80744692234.5135.3167.7Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
80867002233.3196.2465.4Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
80989242231.0250.4962.6GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
81044602230.0116.9858.5A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
81122292229.054.5154.5Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
81222292229.042.5242.5Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
81366862228.7153.4651.2The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
81422272227.053.0553.0Mechanisms and genes of cellular suicide. H StellerScience19957878463No
81522262226.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
81622262226.055.2455.2Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
81744472223.599.8549.9Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
81822232223.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
81922232223.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
82044452222.5149.7574.9Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
82122202220.077.9778.0Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
82222192219.061.8761.9Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
82322192219.068.6168.6Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
82466472215.7178.5959.5RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
82522152215.087.5987.6Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
82622152215.053.1953.2Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
82722112211.050.3550.4A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
82822092209.065.0765.1Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
82922092209.062.0862.1Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
83022062206.048.1748.2Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
83122062206.059.1559.1Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
83222062206.094.6594.7Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
83344082204.0198.2499.1Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
83444082204.0167.683.8The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
83522032203.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
83622022202.084.9985.0Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
83744032201.5120.0860.0Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
83865982199.3189.0363.0Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
83943982199.00.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
84021962196.068.5468.5Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
84143852192.50.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
84221912191.048.7148.7The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
84343822191.0128.8664.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
84421912191.041.8941.9Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
84521842184.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
84643642182.087.9144.0Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
84743642182.0135.4967.7SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
84843582179.095.6447.8Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
84943532176.5109.9255.0Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
85086972174.2287.0171.8clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
85143472173.599.7849.9The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
85221732173.066.1666.2Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
85365192173.0204.2968.1Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
85443442172.0111.3855.7A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
85543392169.5166.8483.4Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
85621692169.081.7581.8Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
85743362168.096.2348.1Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
85821672167.051.651.6Specification of cerebral cortical areas. P RakicScience19883291116No
85921672167.047.4547.5NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
86021672167.070.3670.4The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
86121632163.079.8479.8Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
86243232161.5159.1179.6The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
86321602160.048.6648.7Chemokines. B J RollinsBlood19979242519No
86443172158.5113.8956.9The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
86521582158.057.0457.0T cell exhaustion. E John WherryNat Immunol201121739672No
86621582158.0100.0100.0Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
86743132156.5106.9853.5Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
86821552155.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
86921522152.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
87043002150.0106.153.0Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
87142972148.5136.1668.1Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
87242952147.50.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
87342932146.599.9150.0AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87421462146.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
87564332144.3185.0461.7Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
87621432143.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
87721432143.041.9341.9Protein modules and signalling networks. T PawsonNature19957531822No
87842842142.0111.0955.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
87942832141.5125.0262.5Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
88021402140.043.543.5The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
88142792139.50.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
88221382138.071.9471.9Working memory. A BaddeleyScience19921736359No
88321382138.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
884170942136.8551.3568.9The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
88542722136.0161.4180.7Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
88642682134.00.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
88721332133.089.3889.4A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
88842592129.5130.0865.0Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
88921272127.050.1850.2The inflammatory reflex. Kevin J TraceyNature200212490958No
89042532126.5101.5450.8Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
89121242124.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
89263662122.0168.3456.1Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
89342432121.5115.6257.8UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
89442422121.0107.3253.7Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
89521212121.046.9446.9Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89621202120.075.7575.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
89742382119.00.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
89821132113.050.3650.4Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
89921132113.049.2549.2Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
90021132113.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
90142262113.0121.0360.5Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
90221112111.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
90321112111.053.7153.7RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
90421102110.086.7986.8Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
90563282109.3167.9656.0Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
90621092109.068.368.3Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
90742152107.5123.7661.9Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
90821072107.097.0297.0Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
90921052105.054.754.7Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
91021042104.044.8844.9Mammalian G1 cyclins. C J SherrCell19938513492No
91142012100.5121.2160.6Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
91220982098.053.4753.5Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
91341962098.0124.9562.5The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
91420982098.049.4249.4Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
91541892094.5114.7357.4Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
91620942094.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
91762822094.0146.0948.7MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
91862802093.30.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
91920932093.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
92020932093.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
92162782092.70.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
92220912091.062.8162.8Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
92383612090.2327.982.0Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
92441802090.0107.0853.5Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
92520892089.063.9163.9The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
92662642088.0183.7861.3Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
92720882088.068.9168.9Human error: models and management. J ReasonBMJ200010720363Yes
92820852085.046.3446.3Complement. First of two parts. M J WalportN Engl J Med200111287977No
92920852085.053.2653.3Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
930229272084.3497.4745.2Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
93120832083.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
93220822082.057.657.6The importance of selenium to human health. M P RaymanLancet200010963212No
93341622081.0104.6652.3Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
93441622081.00.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
93520802080.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
93620792079.068.3768.4Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
93720792079.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
93820782078.069.8269.8A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
93920752075.042.0242.0Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
94020732073.058.3858.4Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
94141402070.0116.2458.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
94220702070.068.1668.2Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
94320682068.068.2968.3Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
94420672067.085.0985.1Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
94520672067.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
946103282065.61021.18204.2MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
94720652065.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
94820642064.068.968.9The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
94920642064.058.3958.4Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
95041272063.587.843.9A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
95141232061.581.2540.6The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
95261752058.30.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
95320562056.063.5963.6A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
95420562056.055.0155.0Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
95520542054.042.9743.0Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
95641052052.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
95741042052.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
95820512051.042.942.9G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
95920492049.040.2840.3Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96020452045.083.3483.3A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
96120442044.054.5854.6The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
96220432043.059.8259.8ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
96381482037.0183.6445.9Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
96420362036.070.0570.0Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
96520362036.063.1363.1Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
96620362036.068.7668.8Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
96720352035.066.2766.3Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
96840632031.599.9650.0Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
96920312031.048.2248.2Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
97020312031.058.3858.4Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
97120282028.066.066.0Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
97220282028.056.0356.0The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
97320282028.086.4786.5Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
97440532026.5113.8256.9Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
97520252025.039.7239.7NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
97620242024.053.353.3The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
97720212021.053.4553.5Descending control of pain. Mark J MillanProg Neurobiol200212034378No
97820212021.066.5966.6Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
97920202020.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
98020202020.047.947.9Calcium signaling. D E ClaphamCell19957834745No
98140392019.5106.3153.2The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
98220182018.047.6347.6Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
98340352017.5105.7752.9Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
98420162016.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
98540312015.581.0940.5Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
98620152015.044.6444.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
98740272013.5101.7950.9Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
98840242012.0110.0155.0New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
98940232011.50.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
99020112011.051.2651.3Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
99120092009.050.1550.1Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
99220062006.042.4142.4Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
99340112005.5129.8964.9A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
99460082002.7118.3239.4Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
99540012000.581.7440.9Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
99620002000.042.3342.3XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
997119871997.8271.8945.3NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
99819961996.00.00.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
99919951995.058.5758.6Protein oxidation and aging. E R StadtmanScience19921355616No
100019941994.054.3754.4Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
1001179451993.91001.97111.3Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
100239871993.50.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
100339851992.598.4949.2Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
100419911991.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
100519871987.060.2960.3Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
100619841984.066.6966.7Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
100719841984.045.6845.7A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
100819841984.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
100919831983.055.4655.5The episodic buffer: a new component of working memory? BaddeleyTrends Cogn Sci200011058819Yes
101019811981.083.7883.8The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
101179221980.5201.6750.4Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
101239601980.092.7946.4Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
101319791979.071.0371.0Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
101419771977.056.3756.4Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
101519751975.048.448.4Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
101619731973.072.3872.4International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
101719731973.051.8151.8A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
101839441972.079.8739.9Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
101919691969.053.4153.4Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
102019681968.087.6887.7The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
102119671967.040.9841.0Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
102239321966.0110.9655.5Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys Rev B Condens Matter199410010505Yes
102319661966.078.5478.5Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
102439301965.0181.4290.7Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
102539291964.593.8846.9Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
1026117731962.2396.9766.2Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
102719591959.075.5475.5Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
102858741958.0121.740.6Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
102919571957.035.3935.4ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
103058631954.3196.965.6Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
103158631954.3189.6663.2FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
103219541954.054.5654.6The biology of interleukin-6. T KishimotoBlood19892473791No
103319541954.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
103439051952.585.2842.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
103519501950.039.3839.4CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
103619501950.051.3551.4Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
103758481949.3224.8975.0Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
103819491949.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
103938971948.598.7849.4Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
104038961948.085.4742.7The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
104119461946.035.9536.0In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
104219461946.040.9541.0Molecular bases for circadian clocks. J C DunlapCell19999988221No
104319461946.040.7740.8Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
104438921946.079.4539.7Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
104519451945.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
104638851942.50.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
104719421942.058.1658.2Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
104819421942.060.5760.6TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
104938831941.5108.1754.1Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
105019411941.044.1544.1Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
105138811940.5145.2272.6The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
105219391939.081.9582.0A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
105338741937.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
105419371937.050.9551.0Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
105538731936.579.0739.5Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
105638731936.5117.5958.8Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
105719361936.042.8442.8Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
105819351935.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
105938671933.595.6747.8Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
106019311931.065.3865.4Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
106138621931.00.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
106238581929.0175.0687.5The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
106319291929.052.8652.9The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
106419291929.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
106519281928.043.1543.1Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
106619241924.040.6240.6A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
106738461923.096.4148.2Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
106819221922.048.4748.5Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
106957651921.7181.5260.5The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
107019211921.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
107138381919.099.7349.9Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
107238371918.50.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
107338331916.5103.8851.9Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
107419161916.051.3451.3DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
107538321916.097.5848.8Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
107619161916.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
107738311915.596.9148.5Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
107857461915.3145.0848.4GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
107919151915.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
108038301915.077.6638.8The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
108119141914.055.4955.5Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
108219121912.047.2347.2DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
108319121912.043.3743.4Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
108419121912.049.3749.4Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
108519111911.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
108619111911.038.6938.7Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
108719101910.034.9134.9Signaling--2000 and beyond. T HunterCell200010647936No
108838171908.589.8844.9Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
108919061906.051.2651.3The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
109019051905.050.0150.0Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109157111903.7120.4440.1EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
109219021902.057.1757.2Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
109338021901.00.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
109438021901.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
109519001900.084.184.1Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
109619001900.041.741.7The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
109719001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
109818971897.063.8863.9The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
109918971897.058.258.2Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
110018961896.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
110118961896.052.8952.9Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
110237851892.50.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
110375701892.5189.2547.3p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
110456771892.3182.3660.8Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
110556721890.7139.1546.4APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
110675581889.5252.8563.2Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
110737791889.5109.2854.6Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
110856661888.70.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
110937741887.0123.1761.6Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
111056611887.0183.7261.2Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
111137741887.088.9844.5The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
111218851885.054.9855.0Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
111318841884.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
111418841884.039.2339.2The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
111556511883.7161.5353.8Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
111618831883.054.7354.7Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
111737651882.50.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
111837611880.586.7943.4The Fas death factor. S Nagata, P GolsteinScience19957533326No
111956381879.3213.9771.3Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
112018791879.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
112118791879.034.0634.1The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
112275091877.2158.4139.6WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
112318731873.037.7137.7Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
112418731873.053.4553.5MYC on the path to cancer. Chi V DangCell201222464321No
112518711871.038.0238.0DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
112618711871.046.2246.2DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
112718701870.058.4858.5The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
112818691869.046.046.0Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
112918681868.091.1691.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
113018681868.040.7640.8The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
113118651865.047.2647.3Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
113237271863.593.3646.7Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
113337261863.085.0142.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
113437261863.080.2440.1Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
113518621862.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
113618621862.039.6139.6Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
113737221861.073.0636.5Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
113818611861.040.5840.6TRP channels as cellular sensors. David E ClaphamNature200314654832No
113918601860.047.6647.7Negative refraction makes a perfect lens PendryPhys Rev Lett200011041972Yes
114018601860.037.3837.4Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
114118591859.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
114218581858.0100.97101.0The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
114318581858.058.1858.2PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
114418571857.053.9554.0The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
114518561856.060.2260.2Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
114674161854.0283.0170.8The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114718541854.0107.46107.5Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
114818531853.049.7149.7Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
114937041852.094.7847.4The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
115037021851.0164.1382.1The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
115118511851.052.0552.0Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
115255521850.7183.5261.2AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
115318501850.046.1146.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
115436981849.089.9845.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
115518481848.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
115618471847.049.0149.0Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
115773831845.8290.9172.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
115855321844.00.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
115936871843.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
116018431843.045.5745.6The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
116118421842.059.8659.9Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
116273681842.0256.964.2Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
116318421842.044.3244.3Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
116418421842.046.9647.0Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
116518411841.039.039.0The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
116636721836.00.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
116718351835.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
116818351835.046.846.8Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
116918341834.061.661.6Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
117073311832.8179.9345.0Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
117173281832.00.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
117254911830.3106.2735.4Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
117318301830.049.1549.1An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
117418281828.068.2868.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
117518281828.041.1641.2Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
117636551827.5131.0665.5Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
1177164441827.1579.9264.4STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
1178146091826.1414.5951.8Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
117918261826.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
118036501825.0159.5479.8The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
118118251825.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
118218241824.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
118318241824.033.3233.3Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
118472951823.8288.2472.1A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
118572941823.50.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
118618231823.036.0836.1Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
118718231823.050.4150.4A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
118854671822.3138.2946.1Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
118918221822.052.2652.3Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
1190127511821.6289.641.4Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
119118211821.040.6740.7A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
119218191819.043.443.4Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
119318191819.045.045.0The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
119418181818.040.8640.9The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
119554531817.7125.5241.8A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
119636311815.5102.5551.3The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
119718151815.039.6539.6Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
119818151815.041.4841.5Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
119918151815.047.4947.5Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
120018141814.041.6341.6DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
120118131813.086.8886.9Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
120236241812.0125.6262.8Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
120318111811.041.9642.0Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
120418091809.067.9467.9Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
120518081808.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
120636151807.5123.8661.9Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
120736131806.5120.2460.1Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
120818061806.037.0537.0Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
120936121806.0100.3650.2ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
121018041804.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
121118031803.054.1154.1Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
121236061803.0114.8757.4Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
121336051802.575.337.6Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
121472101802.5177.3544.3Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
121536051802.5114.9157.5Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys Rev B Condens Matter19919997467Yes
121618021802.073.4673.5Perception of risk. P SlovicScience19873563507Yes
121718021802.061.961.9Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
121836021801.094.4447.2A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
121918001800.065.9766.0Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
122018001800.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
122117991799.058.4258.4Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
122217981798.045.6545.6The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
122317971797.043.4743.5The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
122417961796.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
122517961796.057.5557.5Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
1226125711795.9561.1880.2limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
122717941794.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
122817921792.035.6435.6Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
122917921792.043.443.4Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
123053731791.0178.3259.4Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
123117911791.045.4645.5Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
123217901790.045.4245.4Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
123317881788.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
1234125161788.0302.9643.3Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
123517871787.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
123617871787.058.9258.9Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
123717871787.058.6758.7Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
123817871787.051.7751.8Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
123917871787.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
124017831783.093.3793.4Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
124135641782.067.2433.6Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
124217811781.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
124335611780.50.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
124417801780.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
124535581779.00.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
124635581779.093.9847.0Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
124753351778.3139.3346.4Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
124817761776.049.6849.7New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
124917761776.053.0553.0Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys Rev Lett198710034639Yes
125017761776.047.0347.0P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
125135481774.086.3443.2Protein folding in the cell. M J Gething, J SambrookNature19921731198No
125217721772.037.4937.5Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
125335421771.094.447.2Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
125417711771.036.7736.8DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
125517681768.081.8481.8Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
125617681768.061.7761.8Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
125717671767.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
125817671767.075.5975.6KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
125917631763.065.6165.6Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
126017631763.057.1657.2Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
126117621762.054.6354.6An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
126217611761.053.9153.9Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
126335221761.097.848.9Building better batteries. M Armand, J-M TarasconNature200818256660No
126435191759.576.1638.1Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
126517581758.048.0748.1G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
126617571757.062.2462.2The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
126717571757.062.3562.4A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
126817561756.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
126917551755.068.5668.6Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
127017551755.036.536.5An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
127117541754.046.446.4What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
127235071753.583.9842.0Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
127317521752.058.8858.9Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
127417521752.036.2336.2MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
127517521752.067.7167.7The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
127617511751.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
127717481748.040.440.4Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
127817461746.043.043.0Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
127917461746.041.6741.7Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
128034921746.0127.8463.9Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
128117451745.045.045.0The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
128217451745.046.5346.5Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
128334871743.50.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
128434871743.574.237.1Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
128517431743.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
128617421742.040.5940.6Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
128717421742.035.2935.3Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
128852201740.0118.5239.5Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
128917381738.055.4355.4Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
129034761738.088.3344.2The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
129117381738.038.1138.1Exploring complex networks. S H StrogatzNature200111258382No
129217371737.039.0139.0The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
129317371737.036.5536.5Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
129417371737.043.3943.4Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
129517371737.050.7850.8Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
129617371737.074.0774.1Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
129752071735.7101.4733.8Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
129834681734.083.3941.7PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
129917321732.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
130017321732.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
130134641732.0100.3350.2The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
130234611730.593.6346.8Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
130351881729.3113.3937.8Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
130417291729.057.1257.1Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
130517281728.062.2162.2Cyclosporine. B D KahanN Engl J Med19892687689No
130617281728.069.269.2Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
130717271727.036.3836.4Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
130817261726.054.0254.0The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
130917251725.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
131017251725.047.7747.8Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
131168971724.2180.845.2Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
131217241724.057.0257.0Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
131334481724.094.1347.1Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
131417241724.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
131517241724.064.7264.7Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
131617231723.041.9141.9Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
1317120561722.3439.662.8Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
131817221722.058.2758.3Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
131917221722.032.1832.2CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
132017221722.082.5482.5The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
132134411720.576.0238.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
132268751718.8134.5733.6Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
132385931718.6233.5246.7Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
132434371718.591.245.6Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
132517181718.041.3741.4Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
132634351717.50.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
132734351717.568.1334.1SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
132817171717.045.5545.5Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
132934341717.086.2543.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
133034331716.5116.3658.2Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
133151481716.0232.1777.4Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
133217161716.044.5444.5The genetics of ageing. Cynthia J KenyonNature201020336132No
133368621715.5179.1444.8Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
133417151715.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
133534281714.079.0439.5Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
133617131713.057.2657.3The crisis in antibiotic resistance. H C NeuScience19921509257No
133717131713.054.5454.5Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
133817121712.046.9446.9The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
133934231711.579.0339.5Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
134017101710.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
134117101710.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
1342170951709.5542.3554.2Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
134334181709.00.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
134417091709.048.5348.5Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
134517091709.053.9754.0Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
134617081708.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
134717071707.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
134817071707.047.2847.3Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
134917071707.057.5757.6Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
135017061706.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
135117041704.057.4257.4Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
135234081704.0101.6350.8Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
135334071703.578.5939.3Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
135417031703.035.5935.6The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
135517021702.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
135634031701.50.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
135717011701.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
135816981698.031.8831.9How eukaryotic transcriptional activators work. M PtashneNature19883050531No
135916981698.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
136016981698.044.7444.7Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
136116981698.040.1740.2Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
136216961696.045.845.8Integrins. E RuoslahtiJ Clin Invest19911985087No
136333921696.00.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
136416951695.057.1757.2Serum albumin. T PetersAdv Protein Chem19853904348No
136516931693.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
136616921692.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
136784571691.4214.1442.8Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
136884511690.2207.1641.4Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
136916901690.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
137033781689.086.2443.1Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
137116881688.040.7540.8The molecular genetics of cancer. J M BishopScience19873541204No
137216881688.059.059.0Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
137333741687.072.3936.2Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
137433701685.094.9847.5Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
137516851685.032.3632.4Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
137633681684.094.0447.0Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
137767351683.8135.9334.0Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
137867341683.50.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
137916831683.048.4748.5Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
138067271681.8305.076.2jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
138116791679.061.0361.0Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
138216781678.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
138333551677.5136.5768.3miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
138416771677.047.2647.3Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
138516771677.040.1240.1The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
138633521676.00.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
138733501675.081.4940.7Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
138833491674.50.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
138916741674.049.2849.3Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
139016741674.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
139116731673.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
139216731673.045.9345.9Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
139316721672.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
139416711671.045.3445.3Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
139566811670.2327.882.0The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
139616701670.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
139716701670.041.4641.5Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
139833391669.5104.252.1Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
139916691669.037.9638.0Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
140016691669.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
140116691669.058.2758.3Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
140216691669.049.3649.4Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
140316691669.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
140433371668.50.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
140516681668.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
140633341667.0131.4465.7Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
140716661666.00.00.0The micronucleus test. W SchmidMutat Res197548190Yes
140816661666.038.8238.8The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
140916651665.038.9539.0Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
141049891663.0158.3152.8Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
141133241662.0145.1772.6A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
141233241662.0109.054.5Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
141349831661.0152.7850.9Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
1414132831660.4342.2642.8Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
141533201660.00.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
141633191659.5121.4560.7ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
141716591659.041.8341.8Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
141816591659.090.3990.4Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
1419165891658.9531.2353.1The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
142016581658.036.2836.3Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
142116581658.040.8840.9Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
142233141657.086.0543.0Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
142316571657.034.7134.7Points of control in inflammation. Carl NathanNature200212490957No
142433121656.0109.6454.8Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
142516561656.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
142616551655.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
142716541654.071.0171.0The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
142866141653.5153.5638.4Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
142933071653.584.4242.2Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
143033071653.587.8943.9Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
1431115681652.6292.241.7Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
143233011650.588.5844.3Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
143333011650.578.8839.4The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
143416481648.043.9944.0From sensation to cognition. M M MesulamBrain19989648540No
143532961648.095.2747.6Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
143616481648.046.0246.0Leptospirosis. P N LevettClin Microbiol Rev200111292640No
143732961648.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
143816481648.054.0254.0A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
143932951647.590.4445.2The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
144016471647.068.2868.3Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
144132931646.50.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
144265851646.2354.5188.6IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
144316461646.035.4135.4Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
144432911645.50.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
144516451645.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
144616451645.046.546.5Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
144798681644.7281.9947.0Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
144816441644.035.1435.1Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
144916441644.068.968.9The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
145016431643.052.5852.6Metallothionein. D H HamerAnnu Rev Biochem19863527054No
145165721643.0146.7536.7MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
145232841642.078.8739.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
145316421642.032.4932.5Hox genes in vertebrate development. R KrumlaufCell19947913880No
145416421642.040.0440.0Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
145516421642.038.4438.4NADPH oxidase: an update. B M BabiorBlood199910029572No
145616411641.045.7745.8Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
145732821641.071.7135.9Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
145816411641.038.2338.2Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
145916411641.097.9998.0The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
146016401640.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
146116401640.045.545.5Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
146216381638.032.432.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
146316381638.039.5539.5The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
146449111637.0105.5535.2A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
146549081636.0115.0738.4Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
146616351635.047.547.5Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
146716331633.042.3542.4Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
146816311631.043.6843.7Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
146916301630.030.4530.4Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
147016301630.039.7339.7Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
147116291629.063.6763.7Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
147216291629.041.8641.9Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
147332581629.071.4935.7Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
147416281628.050.7550.8A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
147548841628.0134.6844.9The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
147616261626.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
147716261626.049.1749.2Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
147816261626.063.1863.2Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
147916261626.052.0952.1The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
148016251625.058.6958.7Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
148132501625.079.439.7CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
148216251625.033.0433.0Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
148316221622.070.970.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
148416221622.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
148516211621.059.6259.6Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
1486178301620.9468.9542.6PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
148716201620.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
148816201620.032.9432.9The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
148916201620.040.1640.2Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
149032391619.5105.0852.5Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
149116171617.048.8748.9Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
149216171617.032.0932.1Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
149316151615.046.8346.8Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
149416141614.033.3833.4Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
149516141614.050.8450.8Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
149616141614.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
149716121612.042.2942.3Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
149816111611.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
149948321610.7106.4535.5Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
150016101610.047.2947.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
150116101610.036.9937.0Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
150216101610.035.0535.0Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
150316101610.029.5229.5Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
150496581609.7294.3649.1Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
150532191609.577.5338.8Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
150648271609.0129.4843.2Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
150732181609.00.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
150832171608.5126.3163.2The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
150916081608.054.0854.1Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
151032141607.068.1134.1A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
151116061606.040.7340.7Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151216061606.047.347.3Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
151316051605.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
151416051605.00.00.0The inverse care law. J T HartLancet19714100731Yes
151516041604.036.9537.0VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
151648111603.7108.3236.1An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
151732061603.081.7240.9Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
151816021602.046.0946.1Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
151916021602.040.4140.4Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
152016011601.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
152116011601.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
152232001600.063.5531.8Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
152316001600.034.5834.6The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
152447981599.3192.364.1The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
152515991599.040.1740.2Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
152615991599.031.0931.1Switching and signaling at the telomere. E H BlackburnCell200111572773No
152731921596.0113.7356.9Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
152847881596.0159.7653.3Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
152931921596.0101.1950.6Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
153015951595.039.9940.0Tumor necrosis factor (TNF). L J OldScience19852413547Yes
153131901595.062.8131.4Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
153215951595.037.4537.5The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
153315941594.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
153447821594.0136.9645.7Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
153531861593.071.9736.0The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
153615921592.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
153715921592.031.6631.7An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
153815921592.049.6349.6Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
153915921592.043.0743.1THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
154031831591.5104.7152.4Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
154131821591.068.1334.1Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
154215901590.045.7545.8Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
154315901590.055.7755.8Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
154415901590.045.8345.8The in vitro micronucleus technique. M FenechMutat Res200011113469No
154515891589.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
154647671589.00.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
154731781589.096.0948.0Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
154815891589.057.5257.5Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
154931771588.5210.99105.5A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
155015881588.052.8452.8Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
155115881588.054.5654.6Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
155279311586.2204.7941.0Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
155331721586.0165.1682.6Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
155415861586.072.4772.5Mood and memory. G H BowerAm Psychol19817224324Yes
155515861586.030.3230.3Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
155615861586.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
155715851585.057.4757.5Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
155815851585.034.5634.6Neuronal calcium signaling. M J BerridgeNeuron19989697848No
155915851585.036.5236.5AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
156031681584.069.3934.7Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
156131651582.578.4339.2A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
156231631581.588.9144.5Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
156315811581.036.2936.3Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
156415811581.044.9545.0What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
156515801580.034.5834.6On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
156631601580.071.7835.9Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
156715791579.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
156815791579.049.2449.2Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
156915791579.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
157031581579.097.9249.0Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
157131561578.097.748.9Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
157215781578.027.7527.8Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
157315781578.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
157415781578.054.9655.0Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
157515781578.066.6366.6Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
157615771577.050.8650.9Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
157763071576.8229.4357.4SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
157847301576.7134.6844.9Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
157994571576.2198.9133.2Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
158015761576.040.7940.8Molecular biology of prion diseases. S B PrusinerScience19911675487No
158115751575.041.9642.0Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
158231491574.50.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
158315741574.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
158415741574.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
158515721572.035.6835.7The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
158615711571.052.3952.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
158715711571.033.3833.4Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
158815701570.039.5639.6Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
158931401570.075.5637.8Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
159031381569.076.2738.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
159115681568.045.845.8The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
159215671567.072.6872.7What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
159393991566.5221.7437.0Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
159415661566.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
159531311565.576.8338.4The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
159615651565.031.2631.3Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
159746941564.7149.3349.8Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
159831271563.564.9332.5Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
159915631563.042.8342.8The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
160031251562.591.4345.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
160131251562.582.2841.1Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
160231251562.595.3947.7Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
160315621562.067.0867.1A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
160415611561.045.2645.3Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
160515611561.039.3739.4Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
160646811560.3118.7839.6Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
160715601560.030.5630.6Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
160877971559.4178.9235.8Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
160915591559.038.138.1HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
161015591559.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
161115581558.071.0571.0The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
161215581558.041.7341.7Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
161331161558.0128.7464.4Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
161415571557.051.651.6Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
161515571557.036.6936.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
161631131556.50.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
161793381556.3324.3254.1Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
161846671555.7117.2439.1Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
161915551555.060.2360.2Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
162015541554.028.4828.5Altering the genome by homologous recombination. M R CapecchiScience19892660260No
162115541554.057.7157.7The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
162215541554.049.549.5Social relationships and health. Sheldon CohenAm Psychol200415554821No
162315531553.058.0258.0Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
162431041552.074.3337.2Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
162515511551.063.3463.3Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
162631001550.0112.4456.2The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
162746491549.70.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
162815491549.071.471.4Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
162915491549.036.5436.5Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
163030971548.565.9233.0Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
163115481548.029.4829.5How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
163215481548.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
163315481548.036.4336.4Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
163446411547.0103.8734.6Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
163515461546.045.145.1The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
163677221544.40.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
163715441544.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
163815441544.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
163915441544.060.6260.6Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
164015441544.030.7230.7The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
164130861543.00.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
164246271542.3121.0240.3The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
164315421542.037.9838.0Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
164415421542.035.535.5Perceptions of epigenetics. Adrian BirdNature200717522671Yes
164530821541.064.0432.0Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
164615411541.032.6532.6DNA in a material world. Nadrian C SeemanNature200312540916No
164730821541.089.4944.7The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
164830821541.0116.258.1Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
164915401540.083.2683.3Subjective well-being. E DienerPsychol Bull19846399758No
165015401540.037.1937.2A revolution in optical manipulation. David G GrierNature200312917694No
165130781539.060.8330.4Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
165230751537.50.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
165315371537.050.0850.1Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
165430741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
165515361536.034.6234.6Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
165630721536.0103.351.6The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
165715361536.032.5332.5Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
165815361536.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
165915351535.035.6135.6Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
166030691534.584.9842.5Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
166146031534.3157.2152.4A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
166215341534.030.6930.7E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
166315341534.044.3944.4Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
166430681534.092.9546.5Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys Rev Lett198510032153Yes
166515341534.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
166615341534.046.1146.1Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
166730671533.50.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
166830671533.573.1536.6The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
166915331533.00.00.0Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
167030661533.095.6247.8Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
167145981532.792.2530.8T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
167215321532.039.139.1Early signals in the mitogenic response. E RozengurtScience19863018928No
167315321532.031.3531.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
167445961532.0123.341.1A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
167515311531.040.1340.1Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
167630611530.5117.3858.7The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
167715301530.047.9447.9The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
167815291529.034.1934.2Molecular themes in oncogenesis. J M BishopCell19911988146No
167915291529.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
168061141528.50.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
168130561528.00.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
168215281528.038.5538.5The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
168315271527.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
168415271527.033.8433.8Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
168515271527.045.7245.7Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
168615261526.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
168715261526.045.4945.5Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
168815261526.039.0639.1Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
168915251525.055.2255.2Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
169045751525.0185.7261.9Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
169115241524.038.8438.8Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
169260881522.0176.6544.2Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
169315221522.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
169415201520.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
169515201520.00.00.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
169615201520.041.5841.6Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
169715191519.035.7735.8A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
169815181518.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
169960711517.8152.1238.0Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
170060681517.0244.5861.116S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
170115161516.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
170215141514.038.3138.3Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
170315141514.035.4535.5PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
170430271513.588.0344.0EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
170515131513.042.4942.5Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
170615131513.042.0842.1Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
170715131513.054.5654.6Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
170860521513.0177.2744.3Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
170930261513.074.6837.3Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
171030261513.0119.3159.7Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
171145361512.091.2230.4Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
171215111511.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
171330191509.5103.8351.9Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
171415091509.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
171515091509.050.0450.0Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
171615091509.040.4540.5Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
171715091509.051.3251.3Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
171815051505.056.4756.5UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
171930071503.5110.4755.2Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
172015021502.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
172115021502.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
172215021502.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
172315021502.036.436.4In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
172460071501.8250.3762.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
172545051501.785.8328.6Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
172630011500.50.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
172715001500.029.3129.3Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
172814991499.033.533.5An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
172929981499.0105.1152.6Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
173044951498.395.8832.0The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
173129951497.561.0330.5NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
173229921496.067.1133.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
173344851495.0149.0649.7Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
173414941494.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
173514941494.039.2139.2The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
173644821494.0125.5741.9Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
173714931493.042.7442.7Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
173814931493.052.1252.1Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
173929851492.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
174014921492.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
174129821491.066.7333.4Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
174214911491.025.5525.6Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
174314901490.054.3254.3The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
174414901490.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
174514901490.044.2744.3Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
174659581489.50.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
174729791489.5103.2951.6Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
174814891489.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
174929781489.056.7828.4The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
175014891489.029.3529.4Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
175129751487.584.742.4Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
175229751487.5105.5652.8The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
175344621487.3151.6450.5Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
175414871487.052.0552.0Lyme disease. A C SteereN Engl J Med19892668764No
175589211486.8290.6248.4New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
175629731486.588.2644.1An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
175714861486.032.4732.5From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
175814861486.033.8733.9The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
1759148521485.2363.3736.3Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
176014851485.033.5133.5Tumor suppressor genes. R A WeinbergScience19911659741No
176114851485.068.1368.1The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
176214851485.031.8331.8Drug discovery: a historical perspective. J DrewsScience200010720314No
176314851485.033.6133.6Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
176414851485.035.635.6Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
176514851485.037.3437.3The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
176629691484.50.00.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
176729691484.559.5129.8Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
176844531484.3110.5636.9Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
176914841484.040.0440.0Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
177014841484.039.739.7External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
177114841484.055.755.7Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
177214831483.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
177314821482.047.2947.3Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
177414821482.029.729.7Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
177529631481.557.1528.6Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
177629631481.580.4240.2Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
177714811481.029.829.8Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
177859231480.8176.644.1The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
177914801480.037.7837.8Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
178014801480.034.734.7Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
178114801480.035.3735.4Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
178214801480.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
178314801480.050.9751.0The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
178414801480.044.8144.8Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
178559191479.8255.0763.8An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
178614791479.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
178729561478.0110.2855.1The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
178829561478.063.3231.7Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
178944321477.30.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
179014771477.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
179114771477.029.029.0Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
179214771477.030.4830.5Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
179314761476.046.146.1Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
179414761476.037.2237.2The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
179514751475.030.6130.6Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
179614751475.036.4436.4Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
179729491474.568.9434.5The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
179814741474.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
179914741474.049.2649.3Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
180014741474.039.9339.9Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
180114741474.033.7633.8Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
180229481474.061.2130.6Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
180329461473.063.3331.7The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
180458881472.0119.8530.0A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
180529421471.061.2330.6The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
180629421471.080.9140.5Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
180729411470.557.8628.9Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
180814701470.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
180929401470.056.1828.1Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
181014681468.040.6340.6Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
181114681468.028.0928.1Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
181244041468.00.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
181314671467.060.8260.8Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
181414671467.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
181514671467.044.6444.6The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
181629321466.00.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
181714661466.045.3445.3Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
181829291464.576.3538.2Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
181914641464.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
182014641464.035.5935.6The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
182129281464.077.4938.7Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
182214631463.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
182329261463.076.9238.5The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
182414631463.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
182558501462.50.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
182629241462.095.4447.7Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
182714621462.046.9346.9The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
182814621462.036.136.1Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
182987661461.0275.4545.9Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
183029211460.568.7234.4A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
183114601460.033.9634.0Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
183272991459.8305.6161.1UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
183314591459.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
183414591459.060.9561.0Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
183514581458.042.0742.1Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
183614581458.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
183729151457.5120.2860.1Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
183814571457.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
183929131456.584.742.4Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
184014551455.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
184114551455.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
184229091454.50.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
184372701454.0150.4930.1Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
184429071453.50.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
184529071453.591.3245.7Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
184614531453.043.0843.1Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
184729051452.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
184829041452.073.6836.8Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
184929031451.565.5232.8Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
185014511451.00.00.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
185114511451.035.1835.2Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
185214501450.026.026.0Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
185328991449.568.1534.1Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
185428991449.564.8532.4Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
185514491449.045.7545.8Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
185614491449.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
185728971448.559.9630.0Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
185814481448.048.748.7Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
185914481448.034.5234.5Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
186014481448.033.1433.1Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
186128941447.080.3940.2A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
186214471447.041.541.5n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
186357871446.80.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
1864130171446.3405.8445.1The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
186514461446.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
186614461446.039.1839.2Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
186714441444.046.7246.7Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
186828881444.072.6136.3Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
186914441444.027.4727.5Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
187014441444.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
187114441444.032.6432.6Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
187228871443.50.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
187343291443.00.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
187414431443.029.8229.8RNA silencing in plants. David BaulcombeNature200415372043No
187543271442.3106.4735.5Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
187628841442.00.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
187728841442.00.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
187814411441.037.5237.5Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
187928811440.561.3430.7Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
188014401440.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
188114401440.035.9135.9Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
188214401440.046.546.5Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
188314391439.037.6437.6Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
188428781439.066.3233.2Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
188514391439.033.1733.2Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
188628771438.50.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
188743141438.0112.9837.7Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
188814381438.052.3252.3Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
188914381438.059.7459.7Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
189028741437.060.530.2Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
189114371437.034.0534.0PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
189228741437.065.5932.8How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
189314361436.033.7933.8Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
189428711435.569.1134.6Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
189528711435.560.6630.3Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
189614341434.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
189714341434.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
189828671433.594.6147.3The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
189914331433.033.1633.2The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
190014331433.0127.66127.7Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
190128651432.578.7639.4Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
190214321432.027.727.7Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
190314321432.033.0733.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
1904228841430.2815.1350.9Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
190514301430.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
190628601430.060.1330.1A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
190714291429.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
190814291429.073.0173.0Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
190928581429.064.5232.3Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
191014281428.035.4835.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
191114281428.057.9558.0A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
191214281428.038.5238.5A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
191328521426.086.2143.1Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
191428511425.581.4640.7Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
191514241424.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
191614241424.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
191714231423.049.7349.7The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
191828461423.087.1643.6Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
191928461423.095.0247.5Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
192028461423.0102.4151.2Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
192142661422.0122.3640.8The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
192214211421.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
192314211421.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
192414211421.058.4558.5Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
192542631421.093.3931.1NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
192628421421.056.5228.3The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
192728411420.574.1837.1Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
192814201420.042.5142.5Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
192914201420.093.0693.1Metazoan MicroRNAs. David P BartelCell201829570994No
193014191419.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
193128381419.086.0943.0A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
193228361418.066.4933.2The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
193314181418.036.9436.9Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
193428351417.563.4931.7Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
193528351417.574.1437.1Obesity. David W Haslam, W Philip T JamesLancet200516198769No
193614161416.031.6731.7Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
193728311415.585.4642.7The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
193814151415.029.829.8The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
193914141414.037.2437.2The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
194028281414.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
194128281414.0107.9754.0The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
194228261413.086.2843.1Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
194314131413.031.3931.4Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
194428241412.089.7644.9Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
194514121412.039.2139.2A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
194628231411.564.432.2NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
194714111411.076.1876.2The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
194828211410.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
194914101410.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
195014091409.00.00.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
195114091409.036.9537.0Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
195214091409.047.3747.4Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
195328171408.563.531.8Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
195498581408.3217.5631.1Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
195556331408.2147.4636.9Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
195614081408.033.5233.5Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
195714071407.035.8535.9An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
195814061406.049.6349.6The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
195914061406.034.2434.2Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
196014061406.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
196114051405.037.6437.6Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
196228101405.093.3746.7The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
196314051405.028.428.4Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
196498321404.63668.19524.0Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
196570211404.2152.8630.6Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
196614031403.032.1832.2The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
196728061403.086.1243.1Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
196828061403.070.4635.2Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
196914031403.063.5363.5Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
197028051402.50.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
197128041402.00.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
197214021402.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
197356081402.0126.0831.5Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
197414021402.039.8939.9Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
197528041402.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
197614011401.030.2530.2Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
197714011401.030.6530.6Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
197814001400.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
197914001400.033.1833.2Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
198014001400.037.6237.6Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
198127991399.579.3739.7Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
198227981399.0111.9956.0Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
198327981399.00.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
198441961398.7141.9547.3Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
198541941398.098.0932.7Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
198613981398.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
198727951397.577.838.9Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
198813971397.032.9933.0Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
198913971397.044.5444.5Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
199013961396.035.6935.7Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
199127911395.5100.0650.0Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
199241851395.092.4630.8TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
199313941394.038.6438.6Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
199413941394.042.2442.2Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
199513931393.026.5426.5Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
199613921392.029.2329.2Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
199713921392.033.8533.9Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
199841751391.792.8230.9Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
199913901390.00.00.0Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
200013901390.047.6747.7Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
200127791389.570.9135.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
200227781389.062.0931.0An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
200327771388.5169.9685.0Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
200413881388.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
200527751387.50.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
200613871387.092.3792.4The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
200713871387.040.1840.2Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
200813871387.054.8454.8Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
200913871387.034.1734.2Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
201027731386.50.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
201141591386.388.8629.6Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
201213861386.033.633.6The basic science of gene therapy. R C MulliganScience19938493530No
201313861386.045.7745.8Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
201427721386.0163.6381.8Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
201527711385.584.542.2From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
201627701385.077.0538.5Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
201727691384.571.9136.0A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
2018179991384.5491.4737.8Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
201927691384.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
202013841384.041.1141.1The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
202113841384.031.9932.0Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
202213841384.026.4426.4NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
202313841384.031.7531.8The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
202413841384.034.2534.2The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
202513841384.040.1640.2The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
202627671383.577.3438.7Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
202727651382.553.6326.8T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
202813821382.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
202927611380.577.6638.8Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
203013801380.049.8449.8Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
203141361378.793.4831.2Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
203227561378.00.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
203327561378.0122.9161.5ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
203427551377.594.6647.3Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
203527551377.50.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
203627541377.082.541.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
203713771377.066.1466.1Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
203841281376.0107.8335.9Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
203927521376.066.6533.3Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
204027511375.568.434.2Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
204113751375.049.549.5Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
204213751375.025.625.6The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
204327501375.057.1728.6Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
204413751375.048.448.4A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
204513741374.035.1135.1The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
204627471373.5184.4792.2Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
204713731373.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
204827441372.088.3744.2Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
204913721372.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
205027421371.00.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
205113711371.037.0437.0The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
205227411370.585.6442.8The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
205327391369.570.6435.3Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
205413691369.031.4731.5Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
205513681368.046.0546.0Interleukin-1. C A DinarelloRev Infect Dis19846369481No
205613671367.040.6940.7Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
205727321366.099.5949.8Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
205827301365.00.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
205927301365.00.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
206013651365.046.046.0Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
206113651365.030.5530.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
206213651365.039.1439.1Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
206327291364.586.2143.1Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
206413641364.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
206513641364.030.8930.9Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
206613631363.047.1747.2Multiple calcium channels and neuronal function. R J MillerScience19872432656No
206713631363.037.2837.3Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
206813631363.080.9280.9Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
206940881362.70.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
207027241362.077.838.9Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
207113621362.045.945.9The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
207227221361.068.6234.3Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
207327221361.054.6727.3Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
207413611361.043.4743.5The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
207527211360.50.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
207627201360.0105.9753.0PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
207740791359.7118.1139.4I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
207827191359.569.3434.7Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
207913591359.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
208013591359.030.6830.7Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
208127171358.50.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
208213581358.035.4535.5Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
208313581358.042.0242.0A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
208427151357.50.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
208527151357.576.838.4Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
208613571357.035.0835.1Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
208727131356.581.1840.6What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
208854231355.8284.8571.2Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
208913551355.044.9344.9SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
209013551355.034.6334.6Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
209140591353.00.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
209227051352.551.7525.9Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
209313521352.045.7845.8Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
209413521352.041.2541.2Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
209513521352.058.5558.5Selenium and human health. Margaret P RaymanLancet201222381456No
209640541351.3130.5143.5Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
209713511351.044.1244.1The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
209813501350.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
209926991349.50.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
210026991349.577.6638.8Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
210126991349.557.9429.0The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
210213491349.043.5943.6Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
210340461348.7731.74243.9An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
210426971348.570.5535.3Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
210513481348.00.00.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
210626961348.063.0731.5NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
210713481348.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
210813481348.040.5540.5Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
210913481348.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
211013471347.032.9733.0Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
211113471347.034.5234.5Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
211226941347.054.7627.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
211313471347.030.2930.3Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
211413471347.043.5443.5Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
211526921346.0101.2950.6Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
211626911345.553.526.8Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
211713451345.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
211826901345.00.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
211926891344.562.0531.0The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
212013441344.031.8531.9Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
212140311343.70.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
212213431343.00.00.0Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
212326861343.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
212413431343.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
212526861343.056.3728.2A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
212626841342.00.00.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
212713421342.088.1788.2The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
212813421342.030.8330.8Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
212980491341.5281.7447.0TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
213013411341.041.3741.4Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
213113411341.036.6536.6The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
213226821341.081.140.5Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
213326811340.571.4935.7Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
213413401340.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
213513401340.042.0142.0Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
213626791339.50.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
213740171339.0125.1841.7Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
213826771338.571.8935.9ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
213913381338.027.2327.2Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
214013381338.036.5536.5A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
214126751337.595.4947.7A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
214213371337.057.7557.8The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
214313371337.065.1765.2Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
214413371337.029.4929.5A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
214526731336.50.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
214626731336.583.9342.0Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
214713361336.028.1828.2Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
214826711335.575.7437.9The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
214913351335.035.9836.0Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
215040041334.7105.6735.2How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
215126691334.50.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
215226691334.583.2141.6Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
215326691334.571.5335.8Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
215413341334.043.3443.3History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
215513341334.026.9426.9Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
215626671333.564.5332.3The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
215739991333.0142.6147.5Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
215826651332.50.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
215939971332.3105.6235.2The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
216013321332.041.9942.0The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
216113321332.065.8665.9Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
216253261331.50.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
216326631331.561.0730.5Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
216413311331.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
216513311331.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
216613311331.047.747.7Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
216713311331.029.5629.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
216853231330.8125.0431.3Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
216926611330.50.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
217026611330.555.2927.6Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
217113301330.043.5143.5Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
217213301330.040.2940.3Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
217326581329.078.6939.3Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
217413291329.033.2433.2Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
217513291329.00.00.0Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
217613281328.034.5434.5The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
217713281328.035.0635.1Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
217813271327.035.6135.6Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
217913271327.051.1651.2Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
218013271327.025.9225.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
218113261326.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
218213261326.033.0933.1Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
218326511325.587.8643.9Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
218439761325.3148.0649.4CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
218513251325.035.135.1The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
218613251325.026.126.1Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
218726501325.00.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
218826491324.50.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
218913241324.031.831.8Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
219026481324.061.3330.7The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
219113241324.038.7238.7The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
219226471323.554.2527.1An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
219326471323.5149.5874.8The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
219413231323.041.4341.4Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
219513221322.042.5342.5Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
219613221322.042.0742.1The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
219713221322.047.2947.3Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
219813221322.039.7139.7Strong localization of photons in certain disordered dielectric superlattices. JohnPhys Rev Lett198710034761Yes
2199118971321.9375.0441.7The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
220013211321.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
220113211321.037.5437.5Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
220213211321.034.8434.8Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
220326411320.592.6446.3The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
220413201320.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
220526401320.060.6730.3Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
220613201320.030.6330.6Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
220713201320.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
220813191319.059.0459.0Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
220913181318.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
221013181318.042.1142.1The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
221113181318.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
221213181318.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
221326361318.058.4829.2Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
221426341317.00.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
221513171317.029.6529.6Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
221639491316.3187.2262.4Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
221713161316.052.752.7Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
221813161316.029.3829.4The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
221913161316.024.0924.1The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
222013161316.024.2824.3Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
222113161316.025.2125.2The significance of responses of the genome to challenge. B McClintockScience198415739260No
222213161316.046.9547.0Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
222313161316.00.00.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
222426311315.555.0527.5Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
222513151315.033.7633.8N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
222613151315.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
222713141314.022.3122.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
222813141314.032.7232.7The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
222913131313.031.6531.6Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
223013131313.033.3333.3A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
223113121312.029.9529.9Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
223213121312.038.838.8Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
223352471311.8157.0439.3Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
223439331311.098.1132.7The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
223513111311.033.6533.6Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
223626221311.057.9229.0NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
223713101310.042.0742.1Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
223826201310.058.9329.5Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
223913091309.050.7750.8Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
224013091309.031.8431.8Proinflammatory cytokines. C A DinarelloChest200010936147No
224113091309.029.7229.7Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
224226181309.099.3549.7Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
224391621308.9292.7441.8AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
224426161308.060.4430.2Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
224513081308.028.0128.0Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
224626151307.559.9430.0Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
224726151307.564.2832.1Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
224852301307.5129.1732.3The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
224939221307.397.3932.5Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
225013071307.048.7948.8Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
225113061306.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
225226121306.077.7838.9The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
225313051305.037.237.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
225413051305.045.0345.0Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
225513051305.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
225613051305.047.0647.1Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
225791301304.3327.5946.8GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
225813041304.042.0842.1Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
225978241304.0194.532.4GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
226013041304.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
226126081304.0138.2669.1mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
226239111303.785.7428.6Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
226339111303.796.0632.0Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
226439111303.7184.9261.6Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
226526071303.560.0730.0A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
226613031303.032.5232.5The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
226713031303.036.936.9Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
226826061303.092.7846.4How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
226913021302.028.3328.3The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
227013021302.034.2234.2Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
227126021301.053.8126.9Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
227239001300.081.0427.0The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
227325991299.585.4642.7The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
227412991299.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
227512991299.023.2923.3Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
227625971298.50.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
227738941298.0106.6935.6TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
227812981298.028.0928.1Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
227912971297.069.169.1The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
228012971297.036.336.3The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
228112971297.032.4632.5Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
228212971297.094.0994.1Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
228312961296.024.4824.5Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
228412961296.023.0823.1Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
228525911295.576.8638.4miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
228677721295.3208.3834.7Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228777711295.2192.8832.1Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
228825901295.061.9631.0Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
228925891294.50.00.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
229051781294.5126.631.6Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
229125891294.579.9840.0The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
229225881294.00.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
229312941294.035.5935.6Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
2294142291293.5488.0644.4A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
229512931293.046.8446.8The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
229612931293.034.1634.2The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
229712931293.024.1324.1CD95's deadly mission in the immune system. P H KrammerNature200011048730No
229812921292.031.3131.3Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
229912921292.034.1434.1Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
230064601292.0195.3739.1Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
230125831291.5101.450.7Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
230238731291.0137.1245.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
230325821291.071.2535.6Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
230412911291.054.6554.6MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
230525811290.50.00.0A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
230625801290.048.0724.0New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
230712901290.042.0542.0Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
230825801290.084.1142.1Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
230964431288.6244.849.0Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
231025771288.556.7228.4LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
231125741287.00.00.0Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
231212871287.022.7622.8The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
231312861286.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
231425721286.043.5321.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
231512861286.033.8933.9Supported membranes: scientific and practical applications. E SackmannScience19968539599No
231612861286.022.8522.9Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
231725721286.055.3327.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
231812861286.030.2130.2The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
231925721286.065.8132.9Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
232025711285.50.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
232125701285.00.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
232212851285.052.2352.2An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
232325691284.567.6233.8A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
232425691284.5112.0756.0Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
232512831283.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
232612831283.030.730.7Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
232712831283.037.4137.4Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
232812831283.035.5635.6Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
232912821282.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
233012821282.00.00.0Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
233112821282.038.5338.5Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
233225641282.0114.3357.2A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
233312811281.048.1348.1The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
233412811281.027.0427.0The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
233512801280.038.9939.0Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
233612801280.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
233725601280.062.5131.3Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
233812801280.030.6230.6Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
233938381279.3100.1833.4Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
234038381279.3155.0151.7Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
234112791279.041.7341.7phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
234212781278.027.8827.9HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
234325561278.065.9233.0Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
234412771277.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
234512771277.041.9241.9Somatostatin. S ReichlinN Engl J Med19836139753No
234612771277.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
234712761276.027.8827.9Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
234825501275.083.6941.8Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
234925501275.065.4932.7The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
235038241274.782.9527.7A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
235125491274.566.3633.2The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
235225481274.00.00.0Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
235312741274.046.5446.5Substance P. B PernowPharmacol Rev19836196797No
235412741274.034.5834.6Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
235550961274.0216.1554.0Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
235625471273.50.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
235712731273.034.0434.0The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
235825461273.075.0337.5Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
235912731273.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
236025451272.577.5438.8CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
236125451272.5100.3150.2The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
236212721272.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
236325441272.051.1125.6Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
2364101761272.0261.4732.7Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
236512721272.048.3148.3Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
236612711271.023.5123.5c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
236712711271.033.0233.0Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
236812701270.057.5657.6Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
236912701270.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
237063461269.2160.9132.2Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
237112691269.029.1329.1Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
237212691269.045.0645.1Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
237325371268.597.9949.0Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
237438051268.388.7129.6Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
237525361268.046.2423.1Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
237612681268.029.6329.6DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
237712681268.051.351.3Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
237863381267.60.00.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
237912671267.052.6152.6Error in medicine. L L LeapeJAMA19947503827Yes
238012671267.034.7134.7Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
238112671267.067.367.3Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
238225331266.50.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
238312661266.048.2448.2The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
238412661266.038.1638.2Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
238512661266.023.3423.3SUMO: a history of modification. Ronald T HayMol Cell200515808504No
238612661266.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
238725311265.576.9138.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
238812651265.030.7330.7Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
238912651265.034.4534.5The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
239025291264.555.8627.9Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
239112641264.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
239225281264.049.6124.8Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
239325281264.0102.8451.4The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
239412641264.061.8861.9Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
239525261263.055.9128.0Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
239637891263.0113.8437.9A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
239725251262.566.3433.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
239825241262.090.4845.2Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
239912621262.041.4741.5An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
240012611261.025.8925.9Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
240112611261.00.00.0Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
240212611261.026.3326.3Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
240312611261.028.5528.6Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
240463041260.80.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
240512601260.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
240612601260.024.7924.8microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
240763001260.0237.8947.6The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
240812591259.047.1747.2Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
240912591259.028.3828.4Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
241012591259.026.1526.1SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
241125181259.071.2835.6Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
241225171258.553.0326.5Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
241312581258.038.6938.7Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
241412581258.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
241588061258.0263.5637.7Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
241612581258.00.00.0A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
241712571257.033.9634.0Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
241825141257.052.6126.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
241912571257.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
242012571257.040.2840.3The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
242125131256.567.5533.8Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
242212561256.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
242312561256.031.7531.8Apoptosis. J J CohenImmunol Today19938466628No
242412561256.038.2638.3Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
242512551255.056.4156.4Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
242612551255.043.1243.1Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
242712551255.028.1728.2Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
242812551255.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
242912551255.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
243037641254.799.6433.2Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn Sci200010827444Yes
243137631254.390.1430.0Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
2432100341254.2306.2638.3The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
243312541254.035.6235.6Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
243487771253.9364.4352.1Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
243512531253.030.6430.6Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
243612531253.020.8320.8Antigen receptor tail clue. M RethNature19892927501Yes
243775151252.5194.1432.4A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
243825051252.558.8229.4Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
243925051252.579.7939.9Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
244012521252.025.7125.7Searching for genetic determinants in the new millennium. N J RischNature200010866211No
244112521252.029.3929.4Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
244225031251.558.1229.1DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
244325031251.571.1535.6The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
244425001250.057.1628.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
244512491249.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
244624981249.067.8833.9Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
244712491249.039.3439.3Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
244824971248.577.3538.7Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
244912481248.025.8725.9Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
245012481248.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
245124951247.50.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
245212471247.043.7543.8The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
245312471247.024.8824.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
245412471247.035.2535.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
2455112151246.1669.3174.4Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
245612451245.028.2728.3Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
245724901245.0110.9655.5Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
245837331244.3133.6144.5A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
245937331244.386.028.7OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
246012441244.00.00.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
246112441244.056.7456.7Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
246224881244.00.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
246324871243.562.9131.5Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
246412431243.067.8167.8Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
246512431243.028.828.8Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
246649711242.8133.8533.5Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
246724851242.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
246824851242.572.9436.5Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
246937271242.3129.043.0Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
247012421242.035.0435.0Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
247112421242.037.437.4Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
2472136621242.0381.6534.7The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
247337251241.795.4431.8Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
247424831241.565.7932.9Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
247562071241.4150.9730.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
247612411241.042.5142.5How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
247712411241.060.3260.3New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
247812411241.031.2531.2Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
247912411241.026.1526.1The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
248012411241.029.0429.0Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
248112411241.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
248249631240.8174.943.7Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
248312401240.031.9431.9The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
248424801240.080.2140.1Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
248512401240.033.8233.8Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
248612391239.024.8624.9STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
248712391239.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
248824761238.061.9431.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
248924761238.068.5934.3Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
249012381238.041.6441.6Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
249112371237.029.6129.6The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
249212371237.034.7934.8Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
249312371237.032.5432.5Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
249424741237.063.431.7Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
249549471236.8114.6328.7Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
249624731236.591.0145.5The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
249724731236.50.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
249837091236.3168.156.0In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
249912361236.038.238.2Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
250024721236.064.632.3Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
250137071235.779.1326.4Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
250224711235.563.7931.9Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
250324711235.586.8543.4How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
250424701235.046.4123.2Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
250512341234.031.8731.9Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
250624681234.062.331.1The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
250737021234.096.5332.2Atomic force microscope. Binnig, Quate, GerberPhys Rev Lett198610033323Yes
250812341234.029.3329.3Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
250937021234.0113.2737.8Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
251024671233.50.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
251173981233.0233.4938.9A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
251212331233.070.4470.4Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
251312331233.0339.75339.8COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
251424651232.584.7842.4Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
251512321232.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
251624631231.575.4637.7An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
251724621231.069.534.8What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
251812311231.038.738.7Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
251924611230.554.6627.3The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
252024601230.00.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
252124601230.045.8122.9DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
252224591229.50.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
252349161229.0143.8636.0Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
252412291229.061.5761.6The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
252512291229.035.6135.6Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
252612291229.024.6224.6Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
252724571228.568.4634.2Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
252812271227.037.6237.6Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
252912271227.030.1230.1Huntington's disease. Francis O WalkerLancet200717240289No
253036791226.392.2230.7Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
253112261226.028.1628.2Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
253224511225.561.5730.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
253324511225.568.3934.2Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
253412251225.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
253524501225.044.2722.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
253624501225.046.8123.4Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
253712241224.027.2127.2Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
253836721224.074.5324.8The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
253912241224.027.2427.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
254012241224.039.1339.1Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
254124471223.562.731.4Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
254212231223.022.3722.4Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
254324441222.00.00.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
254436661222.0111.537.2Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
254512221222.053.3753.4α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
254636651221.793.2531.1LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
254712211221.023.6923.7Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
254812201220.030.9631.0Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
254960981219.6193.1138.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
255024391219.547.6923.8CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
2551134121219.3331.1730.1New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
255236581219.3105.1535.1trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
255312191219.032.6132.6Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
255424381219.062.3231.2Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
255512181218.026.8626.9Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
255612181218.028.228.2The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
255712171217.031.3131.3Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
255824341217.00.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
255912171217.026.1726.2Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
256012171217.036.1936.2Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
256112171217.039.9239.9Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
256224331216.539.8219.9A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
256336491216.388.0929.4Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
256436491216.389.6429.9Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
256548651216.2101.5725.4Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
256612161216.029.6829.7Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
256724321216.0274.64137.3Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
256812151215.035.9135.9The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
256924301215.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
257012151215.022.1522.1The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
257112151215.032.3432.3Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
257224291214.549.3224.7Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
257324291214.577.5438.8An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
257412141214.055.255.2Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
257512141214.033.9233.9Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
257624271213.560.9230.5Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
257712131213.027.5427.5Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
257836381212.7103.5834.5Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
257912121212.025.4825.5MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
258012121212.029.1329.1Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
258112121212.036.7336.7Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
258224231211.548.2424.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
258324231211.5125.8762.9A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
258436341211.377.6625.9Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
258512111211.047.2547.2Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
258612111211.021.4421.4Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
258712111211.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
258812111211.032.7632.8Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
258924211210.563.6731.8Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
259036311210.381.1127.0Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
259112101210.029.2529.2Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
259212101210.033.733.7The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
259324191209.50.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
259424181209.046.4823.2The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
259512091209.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
259624171208.557.6428.8Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
259724161208.093.8446.9Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
259812081208.038.2938.3Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
259960401208.0116.2823.3Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260012081208.025.9726.0Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
260112081208.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
260212081208.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
260312081208.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
260424151207.559.629.8Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
260536211207.0100.2433.4Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
260612071207.087.9888.0Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
260712061206.029.6829.7Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
260812061206.028.5528.6Growth factors and cancer. S A AaronsonScience19911659742No
260912061206.029.9229.9Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
261036181206.063.0421.0A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
261112051205.048.5748.6Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
261212051205.027.1427.1Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
261312051205.045.7445.7The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
261412041204.054.0754.1Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
261524061203.075.3537.7Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
261612031203.037.3237.3Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
261736071202.3108.4236.1The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
261812021202.032.1632.2Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
261924031201.550.9225.5ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
262012011201.056.2956.3A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
262112011201.038.2438.2Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
262212011201.036.3436.3Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
262312001200.059.3959.4ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
262412001200.054.754.7Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
262512001200.026.8526.9S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
262612001200.028.3928.4Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
262723991199.572.1536.1A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
262835981199.386.5928.9Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
262911991199.031.5531.6Drug delivery and targeting. R LangerNature19989579855No
263011991199.042.7642.8The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
263123971198.560.830.4Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
263247921198.0110.5127.6A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
263323961198.078.4539.2Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
263423951197.5115.3257.7The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
263511971197.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
263611971197.043.5143.5Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
263711971197.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
263811971197.048.4548.5Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
263911971197.031.6331.6Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
264011971197.027.8527.9Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
264111971197.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
264235901196.7192.4664.2Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
264311961196.027.2327.2Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
264411961196.034.7334.7Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
264523921196.050.925.4Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
264611961196.031.6131.6Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
264723911195.555.3327.7Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
264811951195.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
264911951195.045.4745.5Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
265011951195.042.9142.9Plasma perspective on strong field multiphoton ionization. CorkumPhys Rev Lett199310054556Yes
265111951195.029.7929.8The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
265211951195.022.8622.9Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
265311951195.035.4135.4The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
265423891194.564.7832.4Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
265535831194.387.5329.2Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
265623871193.556.7728.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
265723871193.5121.1260.6Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
265811931193.00.00.0Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
265911931193.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
266011931193.041.6741.7Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
266111931193.025.9726.0The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
266211931193.025.2325.2Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
266311931193.032.8732.9The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
266411921192.029.8129.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
266523841192.064.3432.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
266611921192.031.9331.9The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
266735731191.0126.3742.1Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
266811911191.042.2542.2Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
266923801190.054.9527.5Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
267011901190.038.3838.4Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
267171391189.8187.7831.3Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
267211891189.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
267311891189.044.8744.9A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
267411891189.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
267511891189.028.7728.8Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
267611891189.022.222.2Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
267723781189.065.8232.9Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
267835661188.7102.4934.2Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
267911881188.038.1338.1The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
268095021187.8453.1956.6The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
268123751187.50.00.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
268223751187.559.929.9Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
268311871187.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
268411871187.037.1237.1Endometriosis. Serdar E BulunN Engl J Med200919144942No
268511861186.024.6724.7Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
268611861186.029.6929.7Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
268711861186.025.8725.9Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
268811861186.030.0430.0Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
268935571185.773.5524.5Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
269023711185.553.6726.8The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
269123711185.5154.0477.0Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
269223711185.564.1732.1A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
269311851185.029.9129.9Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
269423701185.00.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
269511851185.023.6923.7Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
269611841184.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
269711841184.033.1233.1How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
269823671183.563.7831.9Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
269947321183.0102.4725.6Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
270023651182.548.1224.1Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
270111821182.028.5828.6Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
270223641182.099.1549.6Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
270311821182.026.5926.6Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
270411821182.033.2833.3Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
270511821182.026.2426.2Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
270611821182.041.3241.3The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
270711811181.041.0341.0The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
270811811181.025.7125.7The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
270911811181.031.0831.1Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
271011811181.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
2711165321180.9361.6925.8Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
271211801180.036.7836.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
271323601180.046.4623.2Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
271411801180.034.7734.8Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
271511791179.036.236.2The mysteries of lipoprotein(a). G UtermannScience19892530631No
271635371179.0102.9334.3Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
271735361178.786.528.8Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
271823571178.5123.8161.9Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
271970671177.8136.1222.7Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
272011761176.025.2225.2Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
272111761176.026.1926.2The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
272211761176.026.1626.2Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
272335261175.387.8929.3Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
272411751175.00.00.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
272511751175.048.8548.9Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
272611751175.039.5239.5Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
272711751175.061.5261.5Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
272811751175.033.9834.0The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
2729105731174.8355.4639.5A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
273011741174.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
273123481174.095.5447.8Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
273211741174.026.6626.7Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
273323481174.066.4633.2Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
273411731173.026.1426.1The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
273511731173.031.7931.8Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
273611721172.00.00.0The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
273723441172.063.0431.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
273811721172.019.519.5Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
273911721172.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
274011711171.028.1428.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
274111711171.027.7327.7The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
274211711171.037.0437.0Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
274323411170.50.00.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
274423401170.0113.5156.83D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
2745128671169.7365.3933.2The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
274623381169.070.2435.1Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
274711691169.021.421.4Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
274811691169.052.5452.5Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
274923381169.0146.6573.3A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
275011691169.033.6833.7Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
275170141169.0236.9539.5Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
275235071169.072.4824.2Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
275311691169.023.4723.5IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
275411691169.031.1731.2Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
275511691169.033.2633.3Plant productivity and environment. J S BoyerScience198217808529Yes
275658411168.2191.8238.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
275711671167.027.0727.1Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
275811671167.025.825.8Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
275923341167.0137.2268.6MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
276011661166.079.1979.2The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
276111661166.032.2732.3Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
276211661166.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
276311651165.00.00.0Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
276411651165.045.445.4Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
276511651165.032.5232.5Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
276611651165.053.4453.4Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
276734941164.70.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
276834941164.70.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
276923291164.551.125.6Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
277011641164.029.8229.8Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
277111641164.026.3226.3Human natural killer cells. Michael A CaligiuriBlood200818650461No
277223281164.079.3739.7LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
277323261163.062.8731.4Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
277411631163.070.770.7Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
277534861162.00.00.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
277611621162.060.0160.0Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
277723241162.051.9226.0Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
277811621162.027.3427.3Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
277911611161.022.2822.3Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
278011611161.030.6430.6Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
278111611161.073.6873.7Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
278211611161.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
278311601160.040.7940.8Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
278411601160.029.9529.9Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
278511601160.027.027.0Brain tumors. L M DeAngelisN Engl J Med200111150363No
278611601160.032.1132.1Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
278723181159.076.9438.5Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
278823181159.00.00.0Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
278911591159.026.0926.1Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
279011591159.046.3846.4The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
279123171158.563.6431.8EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
279223161158.093.9747.0The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
279323161158.00.00.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
279411581158.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
279511581158.027.7627.8Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
279623131156.50.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
279734671155.797.7532.6Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
279811551155.025.9626.0Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
279911551155.020.7320.7Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
280011551155.019.7719.8Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
280123101155.064.6632.3Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
280211551155.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
280334631154.30.00.0High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
280434631154.394.2131.4Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
280511541154.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
280611541154.028.4228.4Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
280723061153.063.1131.6Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
280823051152.542.221.1Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
280923051152.50.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
281034571152.372.8424.3Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
281111521152.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
281234561152.087.6729.2Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
281311521152.026.3726.4Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
281423031151.599.5949.8Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
281546051151.2113.1228.3Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
281623021151.048.7724.4Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
281711511151.031.0431.0Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
281823021151.065.7632.9The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
281946021150.5135.2833.8Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
282023011150.569.0934.5Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
282123011150.554.9827.5Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
282223011150.5137.969.0Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
282311501150.041.3741.4The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
282423001150.052.5826.3Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
282522981149.00.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
282622981149.049.6824.8Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
282734461148.769.8723.3Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
282822971148.50.00.0Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
282922971148.565.7332.9Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
283011481148.034.4434.4The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
283122961148.073.6136.8Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
283211481148.029.9229.9Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
283322951147.565.2732.6Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
283411471147.039.4639.5Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
283522931146.548.9224.5Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
283622931146.545.7122.9Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
283722931146.555.827.9Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
283811461146.00.00.0Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
283911461146.046.3546.4Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
284011461146.034.5834.6Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
284111461146.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
284234381146.0109.8836.6MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
284311461146.023.8923.9Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
284411461146.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
284511461146.034.5934.6High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
284622901145.00.00.0Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
284711451145.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
284834341144.779.3826.5Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
284922881144.064.4132.2Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
285022881144.046.5923.3A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
285111441144.033.4633.5A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
285211441144.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
285311441144.032.3232.3DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
285411441144.031.131.1Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
285511441144.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
285611441144.029.6629.7Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
285745741143.5109.0227.3Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
285822871143.554.0527.0Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
285922871143.551.8225.9The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
286022871143.551.3325.7Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
286122861143.045.2522.6Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
286222861143.00.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
286311431143.032.1532.1The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
286434281142.70.00.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
286511421142.047.7447.7A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
286611421142.039.9640.0Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
286722831141.571.1135.6Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
286811411141.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
286911411141.032.8132.8The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
287011411141.034.8334.8Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
287111411141.027.827.8Optical microcavities. Kerry J VahalaNature200312917698Yes
287234231141.0110.7536.9Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
287311411141.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
287411411141.032.5732.6Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
287511411141.033.8233.8Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
287611411141.038.9939.0Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
287711411141.037.0637.1Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
287811401140.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
287911401140.028.1228.1Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
288011401140.036.6336.6Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
288145581139.5157.0239.3Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
288211391139.024.3724.4Stem cells in the central nervous system. R McKayScience19979082987No
288311391139.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
288434171139.0160.653.5The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
288511381138.00.00.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
288634141138.088.3529.4Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
288711381138.024.8424.8An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
288811381138.022.2322.2Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
288911381138.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
289022751137.569.9135.0Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
289122751137.585.3942.7Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
289211371137.036.5336.5Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
289311371137.023.4723.5Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
289422741137.060.5330.3Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
289511371137.027.0327.0Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
289611371137.032.5732.6Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
289734091136.30.00.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
289811361136.027.9427.9Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
289911361136.041.2141.2AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
290022711135.579.6339.8Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
290134061135.378.0326.0Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
290211351135.00.00.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
290311351135.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
290422701135.066.7533.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
290511351135.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
290611351135.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
290711351135.038.3238.3How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
290845391134.8111.6727.9Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
290922691134.562.8231.4A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
291011341134.00.00.0A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
291111341134.041.3141.3Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
291211341134.026.7526.8Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
291311341134.040.0640.1Density matrix formulation for quantum renormalization groups. WhitePhys Rev Lett199210046608Yes
291411341134.030.2930.3Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
291511331133.042.1542.1The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
291645321133.0107.2726.8Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
291722661133.056.3228.2C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
291879311133.0162.0623.2Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
291922661133.067.0433.5Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
292067941132.3206.5234.4Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
292111321132.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
292211321132.047.5647.6What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
292322631131.559.2129.6Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
292411311131.031.1231.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
292511311131.033.8433.8Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
292622621131.061.4930.7Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
292711311131.028.3628.4Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
292822611130.598.7349.4Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
292922611130.566.8833.4Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
293022611130.544.2522.1NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
293111301130.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
293211301130.030.6930.7Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
293311301130.039.2339.2The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
293445191129.8127.0631.8Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
293522591129.541.7120.9Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
293622591129.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
293722591129.548.424.2NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
293811291129.031.5631.6Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
293922581129.051.3325.7Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
294011291129.0105.15105.2The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
294111291129.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
294222581129.066.9333.5Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
294311291129.035.5135.5Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
294411281128.033.8733.9Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
294511281128.00.00.0Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
294611281128.026.5726.6Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
294711281128.022.0622.1Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
294811281128.029.0929.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
294911281128.031.4431.4Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
295011271127.00.00.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
295111271127.028.728.7Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
295222541127.084.742.4Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
295322541127.00.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
295411271127.023.6123.6Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
295511271127.055.5455.5Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
295611261126.022.2722.3Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
295711261126.033.733.7Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
295811261126.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
295922521126.062.0231.0Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
296045021125.5102.625.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
296111251125.043.2943.3On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
296245001125.0131.1132.8Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
296367491124.8233.1838.9The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
296422481124.069.8934.9A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
296511241124.030.3730.4The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
296622481124.047.9424.0The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
296711241124.039.3539.4Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
296833701123.379.9326.6Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
296911231123.037.2337.2Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
297011231123.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
297156121122.4192.3938.5Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
297211221122.029.8929.9The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
297322431121.543.4421.7Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
297444851121.2104.5726.1SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
297511211121.031.2731.3Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
297611211121.031.331.3Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
297711201120.00.00.0Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
297822401120.044.4222.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
297911201120.033.0633.1Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
298011201120.027.4227.4Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
298144781119.50.00.0Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
298211191119.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
298322361118.00.00.0Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
298411181118.042.0942.1Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
298511181118.024.5924.6Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
298611181118.032.7332.7Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int2007