Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 4132 papers with ECcit ≥ 1095.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 64, December 2025

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1226229226229.04716.34716.3Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2182039182039.07187.67187.6A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328819672049.00.00.0Protein measurement with the Folin phenol reagent. O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALLJ Biol Chem195114907713Yes
413838269191.03373.11686.5Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54670046700.01370.81370.8A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63876038760.01244.21244.2Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76475632378.01931.0965.5Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83026730267.0810.6810.6Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92973329733.0685.7685.7MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
102949929499.0927.1927.1The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
112906829068.0624.6624.6MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
122761127611.0700.9700.9A rating scale for depression. M HAMILTONJ Neurol Neurosurg Psychiatry196014399272Yes
132644426444.0596.3596.3A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142562425624.0798.2798.2Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
154780123900.51398.9699.5Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
162342623426.0629.4629.4Projector augmented-wave method. P E BlochlPhys Rev B Condens Matter19949976227Yes
176998823329.32508.0836.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
186642022140.01632.4544.1DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
192192121921.0740.5740.5Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
204191020955.01291.5645.8The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
216250220834.02150.2716.7Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
222050020500.00.00.0Tissue sulfhydryl groups. G L ELLMANArch Biochem Biophys195913650640Yes
232047420474.0204.0204.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S REYNOLDSJ Cell Biol196313986422Yes
243971419857.01605.6802.8The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
251980719807.0767.9767.9RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
263830619153.01138.7569.4Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
273798018990.01761.3880.6Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
285692718975.71633.7544.6Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
291845918459.0677.5677.5A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
301833618336.0747.3747.3A power primer. J CohenPsychol Bull199219565683Yes
315366117887.02029.8676.6Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
323569117845.5864.3432.1Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
331734717347.0427.3427.3Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
341705117051.0769.8769.8Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
351677516775.0283.0283.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DAVISAnn N Y Acad Sci196414240539Yes
363343516717.51313.6656.8The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
373341716708.50.00.0A rapid method of total lipid extraction and purification. E G BLIGH, W J DYERCan J Biochem Physiol195913671378Yes
381622616226.0442.9442.9High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
391619916199.0388.7388.7MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
401613916139.0617.2617.2Catalase in vitro. H AebiMethods Enzymol19846727660Yes
413211516057.51188.7594.4Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
421593815938.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BURTONBiochem J195613293190Yes
433184515922.5846.0423.0Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmullerPhys Rev B Condens Matter19969984901Yes
444646215487.31315.5438.5CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
454321514405.00.00.0A simple method for the isolation and purification of total lipides from animal tissues. J FOLCH, M LEES, G H SLOANE STANLEYJ Biol Chem195713428781Yes
461437314373.0536.1536.1Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
474300414334.71538.8512.9Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
481396813968.0337.5337.5Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
491370613706.0452.5452.5Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
502736913684.5547.1273.6Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
512734913674.5725.0362.5Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
526812213624.41943.4388.7Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
532704513522.5962.4481.2MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
541347913479.0606.1606.1Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
551343813438.0405.4405.4Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
561324813248.0395.0395.0The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
572638613193.01061.0530.5The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
583952913176.31365.6455.2Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
592586212931.0546.8273.4KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
601290612906.0149.4149.4The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
611272112721.0524.1524.1Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
623811112703.7981.0327.0VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
631266012660.00.00.0Phosphorus assay in column chromatography. G R BARTLETTJ Biol Chem195913641241Yes
641257612576.0410.0410.0Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
653744112480.31183.1394.4NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
661213812138.0453.9453.9A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
672392311961.5512.4256.2Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
684699411748.51310.1327.5Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
691151111511.0509.4509.4SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
702224111120.5925.4462.7The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
711108311083.0279.0279.0Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
721085910859.0353.6353.6Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
732156310781.5555.6277.8A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
741077210772.00.00.0On the origin of cancer cells. O WARBURGScience195613298683Yes
751048910489.0440.1440.1Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
761045610456.0283.2283.2The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
771031110311.0196.5196.5Improvements in epoxy resin embedding methods. J H LUFTJ Biophys Biochem Cytol196113764136Yes
784110810277.01484.0371.0A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
791026910269.0290.2290.2Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
804065610164.01295.6323.9Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
813043010143.3871.3290.4The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
821009510095.0203.6203.6Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
832014710073.5588.9294.4AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
843002110007.0758.3252.8edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
8599119911.0231.2231.2PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
86198179908.5356.4178.2The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
87197939896.5502.0251.0Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
8898459845.0272.3272.3Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
8997989798.0251.5251.5Canonical dynamics: Equilibrium phase-space distributions. WG HooverPhys Rev A Gen Phys19859895674Yes
9097879787.0381.0381.0UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
91194999749.5499.3249.7A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
9296509650.0317.0317.0Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
9396419641.0242.6242.6RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
94191909595.0391.6195.8The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
9595209520.0251.0251.0Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
96285449514.7697.8232.6Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9794749474.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
98189149457.0429.7214.8BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
9994499449.0238.8238.8Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
100185589279.0392.7196.3Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10192559255.0236.7236.7Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
10292549254.0261.1261.1Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
10392159215.0257.4257.4The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
104274689156.01341.1447.0MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
105456609132.01686.0337.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, PLoS Med200919621072No
10690929092.0231.7231.7Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
10790199019.0176.8176.8Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
108359868996.51147.8286.9G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
109179768988.0586.4293.2Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
11089758975.0260.8260.8AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
11189498949.00.00.0The assessment of anxiety states by rating. M HAMILTONBr J Med Psychol195913638508Yes
11288738873.0183.3183.3The functions of animal microRNAs. Victor AmbrosNature200415372042No
113177368868.0405.9202.9WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
11487188718.0355.1355.1Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
11586308630.0391.6391.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
116172478623.51026.0513.0A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
117258078602.3759.6253.2Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
118168898444.5375.8187.9Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
119252108403.3856.1285.4Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
12083088308.0224.5224.5Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
12181558155.0339.2339.2Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
12281528152.0196.8196.8Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
123162898144.5389.9194.9MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
12481438143.0197.3197.3Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
12580398039.0249.0249.0The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
12680068006.0155.1155.1Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
12779967996.0164.6164.6Chromatin modifications and their function. Tony KouzaridesCell200717320507No
12879527952.0273.9273.9The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
12979287928.0218.1218.1"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
13078817881.0225.6225.6A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
13178787878.0255.6255.6Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
132156577828.5426.3213.2EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
13378067806.0214.7214.7The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
134233717790.3902.8300.9Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
13577677767.0231.0231.0The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
13677367736.0222.8222.8Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BoyumScand J Clin Lab Invest Suppl19684179068Yes
13777247724.0218.6218.6Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
13876617661.0246.9246.9An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
139152637631.5402.0201.0RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
14076317631.0194.3194.3A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
141532857612.11352.9193.3Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
142150047502.0382.1191.1Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
14374007400.0119.2119.2A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
14471217121.00.00.0Index for rating diagnostic tests. W J YOUDENCancer195015405679Yes
145142017100.5774.1387.1Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14670907090.0191.1191.1TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
147141717085.5475.5237.8Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
148140187009.0349.1174.6Continuous cultures of fused cells secreting antibody of predefined specificity. G Kohler, C MilsteinNature19751172191Yes
14969176917.0114.9114.9A Self-Rating Depression Scale. W W ZUNGArch Gen Psychiatry196514221692Yes
15068676867.0183.0183.0The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
15168326832.0132.3132.3Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
15268026802.0154.2154.2Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
15368006800.0201.9201.9Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
15467336733.0217.1217.1Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
15567126712.00.00.0The thiobarbituric acid assay of sialic acids. L WARRENJ Biol Chem195913672998Yes
15667116711.0153.3153.3Inflammation, atherosclerosis, and coronary artery disease. Goran K HanssonN Engl J Med200515843671No
157134026701.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N MANTEL, W HAENSZELJ Natl Cancer Inst195913655060Yes
158133426671.0310.1155.1Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
159132826641.0445.8222.9The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
16066126612.0154.0154.0Inflammation and metabolic disorders. Gokhan S HotamisligilNature200617167474No
16166116611.0168.9168.9Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
162198076602.3552.2184.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
16365796579.0169.9169.9Adhesion receptors of the immune system. T A SpringerNature19901974032No
164196356545.0978.1326.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16565046504.0149.5149.5Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
166129916495.5515.3257.6Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
167388666477.71302.7217.1Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
16864586458.0147.8147.8Free radicals in the physiological control of cell function. Wulf DrogePhysiol Rev200211773609No
16964556455.0135.4135.4p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
17064456445.0137.3137.3Inflammation in atherosclerosis. Peter LibbyNature200212490960No
17164356435.0220.3220.3FreeSurfer. Bruce FischlNeuroimage201222248573No
17264216421.0128.9128.9Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
17363966396.0117.0117.0BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
17463786378.0275.2275.2Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
17563066306.0170.3170.3A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
176125836291.5337.8168.9Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
17762646264.0201.0201.0Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
17862356235.0140.3140.3Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
17962316231.0138.9138.9Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
180123856192.5263.0131.5One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
181123696184.5281.3140.7Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
182123606180.0296.3148.2MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
18361786178.0133.6133.6MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
18461746174.077.977.9The Environment And Disease: Association Or Causation? A B HILLProc R Soc Med196514283879Yes
185122836141.5444.9222.4A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
18661006100.0185.0185.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
18760926092.0152.6152.6G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
18860886088.0146.6146.6Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
18960606060.0151.2151.2Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
190121056052.5461.3230.7phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
191241216030.2684.6171.2clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
192239725993.0789.1197.3Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
19359865986.0567.7567.7Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
194118995949.5390.6195.3Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
195178325944.0544.4181.5featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
19659385938.0153.6153.6How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
197117705885.0247.1123.5MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jurgen Cox, Matthias MannNat Biotechnol200819029910Yes
19858735873.0141.7141.7Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
199234865871.5567.2141.8Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
20058645864.0149.7149.7Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
20158505850.0178.7178.7jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
202233935848.2689.5172.4A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
203116965848.0283.7141.8Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
20458435843.0230.0230.0Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
205116405820.0240.8120.4Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
20658155815.00.00.0Aging: a theory based on free radical and radiation chemistry. D HARMANJ Gerontol195613332224Yes
20757565756.0213.6213.6Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
208172575752.3634.5211.5The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
209114765738.0247.3123.7Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
21057375737.0142.3142.3Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
211114515725.5193.496.7The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T OMURA, R SATOJ Biol Chem196414209971Yes
21257185718.0119.2119.2Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
21357155715.0215.0215.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
214114135706.5731.6365.8Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
215114115705.50.00.0A series of normal stages in the development of the chick embryo. V HAMBURGER, H L HAMILTONJ Morphol195124539719Yes
21656995699.095.395.3Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
217113355667.5533.1266.6A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
218112555627.5256.2128.1A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stephane Guindon, Olivier GascuelSyst Biol200314530136Yes
219112465623.0296.0148.0Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
22056145614.089.789.7Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
22155985598.0118.7118.7The biochemistry of apoptosis. M O HengartnerNature200011048727No
22255845584.0163.7163.7Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
223167365578.7501.1167.0A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
224110795539.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L HODGKIN, A F HUXLEYJ Physiol195212991237Yes
225165955531.7644.2214.7Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
226165375512.3645.5215.2A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
227165195506.3400.9133.6Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
228109315465.5284.8142.4Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
229108845442.0359.0179.5Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
23054405440.0103.3103.3Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
23154115411.053.253.2The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LAURENActa Pathol Microbiol Scand196514320675Yes
232108155407.5299.9149.9MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
23353935393.0135.7135.7The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
23453735373.0235.8235.8Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniel LakensFront Psychol201324324449No
235268555371.0718.8143.8The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
23653635363.0127.6127.6Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
23753575357.0104.3104.3Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
238107085354.0227.1113.5The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23953415341.0127.3127.3The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
240106385319.0250.6125.3Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
24153085308.0134.8134.8New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
24252725272.0151.5151.5Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
243157155238.3544.1181.4HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
24452345234.0188.8188.8Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
245104615230.5180.090.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
24652215221.00.00.0[A micro-method of immuno-electrophoresis]. J J SCHEIDEGGERInt Arch Allergy Appl Immunol195513262900Yes
24752035203.068.468.4Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
248104065203.0364.2182.1The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
249103755187.5165.182.5Functional Evaluation: The Barthel Index. F I MAHONEY, D W BARTHELMd State Med J196514258950Yes
25051875187.0156.6156.6Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
25151665166.0101.5101.5Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
252257645152.81037.1207.4MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
253154425147.3502.7167.6HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
254102785139.0271.6135.8Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schagger, G von JagowAnal Biochem19872449095Yes
255102555127.5359.0179.5Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
25651235123.0187.8187.8Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
257102425121.0264.1132.1The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
25850915091.0113.6113.6The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
25950915091.0144.0144.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
260101765088.0238.1119.0A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
261151445048.0475.8158.6Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
262252135042.6412.682.5An inventory for measuring depression. A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGHArch Gen Psychiatry196113688369Yes
263151265042.0656.5218.8Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
26450345034.091.891.8DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
265149934997.7540.3180.1Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
266199124978.0617.2154.3A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LoweArch Intern Med200616717171Yes
26799384969.0223.6111.8Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26849494949.0123.4123.4A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
269197734943.2308.477.1A new and rapid colorimetric determination of acetylcholinesterase activity. G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONEBiochem Pharmacol196113726518Yes
27049124912.0156.0156.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
27149104910.0113.5113.5Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
27297854892.5348.7174.3Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
27348874887.097.397.3An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
274146554885.0392.5130.8Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
27597694884.5356.2178.1The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
276339414848.7731.5104.5UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
27748484848.0203.5203.5The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
278145124837.30.00.0Determination of serum proteins by means of the biuret reaction. A G GORNALL, C J BARDAWILL, M M DAVIDJ Biol Chem194918110453Yes
27948374837.0104.2104.2Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
28096704835.0228.8114.4Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
28148214821.0107.4107.4ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
28296344817.0390.0195.0The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
283144434814.3355.7118.6A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
28448114811.0104.5104.5Cancer cell cycles. C J SherrScience19968939849No
28548094809.040.640.6The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HAYFLICKExp Cell Res196514315085Yes
28648054805.057.557.5Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RODBELLJ Biol Chem196414169133Yes
28747894789.0104.4104.4Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
288143674789.0309.2103.1Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
28995284764.0158.879.4A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
29095104755.0236.8118.4Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
29147524752.094.794.7Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
29294664733.0236.6118.3Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
29347184718.0128.5128.5Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
29494264713.00.00.0Radiological assessment of osteo-arthrosis. J H KELLGREN, J S LAWRENCEAnn Rheum Dis195713498604Yes
29547114711.0264.9264.9Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BORNNature196213871375Yes
29647074707.0155.8155.8The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
29794004700.0359.1179.6The qualitative content analysis process. Satu Elo, Helvi KyngasJ Adv Nurs200818352969Yes
29893864693.0136.468.2Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
29946784678.0129.5129.5Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
300187004675.0520.6130.2MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
30146744674.0142.6142.6Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
30246674667.048.848.8The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
303233184663.6880.7176.1The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
30446614661.0120.4120.4A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
30592974648.5253.0126.5Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
30646484648.0172.5172.5Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
30746464646.095.695.6Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
30892914645.5228.4114.2Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30946384638.0133.9133.9DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
31092754637.5202.5101.2Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
31146184618.0165.0165.0EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31246094609.091.491.4Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
31346014601.0104.3104.3Cancer. p53, guardian of the genome. D P LaneNature19921614522No
31491724586.0288.0144.0FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoc, Steven L SalzbergBioinformatics201121903629Yes
31591714585.5262.8131.4Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
316137364578.7469.9156.6Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
31791124556.0241.4120.7A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
31845524552.096.796.7ras genes. M BarbacidAnnu Rev Biochem19873304147No
31990894544.5208.1104.0SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
320136334544.3495.8165.3A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
32145284528.090.890.8Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
32245274527.0163.1163.1A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
32345254525.086.686.6The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
32445224522.084.684.6The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
32545184518.0123.1123.1Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
32644774477.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B DE B WEIRJ Physiol194915394301Yes
32744554455.0134.2134.2How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
328267284454.7861.5143.6Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32944424442.0105.3105.3Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
33088814440.50.00.0A simplified method of evaluating dose-effect experiments. J T LITCHFIELD, F WILCOXONJ Pharmacol Exp Ther194918152921Yes
33144374437.0112.0112.0A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
33244354435.0107.3107.3A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
33344334433.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
33444264426.0111.2111.2Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
33588444422.0207.2103.6Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
336265254420.8915.5152.6MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
33744104410.0101.9101.9Mechanisms of angiogenesis. W RisauNature19979109485No
33844054405.093.293.2Atherosclerosis. A J LusisNature200011001066No
33943994399.0112.3112.3Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34043904390.090.990.9Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
34187714385.5162.081.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
34243654365.0110.0110.0Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
34343554355.0221.4221.4Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
34443464346.0111.2111.2Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
34586754337.5266.5133.2DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
34643374337.0128.0128.0Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
34743304330.0118.9118.9The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
34886444322.0219.3109.7tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
349215254305.01235.1247.0MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
35085944297.0214.5107.2Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
35142974297.0106.4106.4Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
35285914295.5225.6112.8Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35385844292.0466.3233.2Preparation of iodine-131 labelled human growth hormone of high specific activity. W M HUNTER, F C GREENWOODNature196214450081Yes
35442884288.093.893.8PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
35542864286.0113.1113.1Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
356428294282.91038.7103.9The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, Bioinformatics200919505943Yes
35742814281.087.687.6The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
35842784278.091.691.6Apoptosis by death factor. S NagataCell19979039262No
35942754275.00.00.0Estimation of nuclear population from microtome sections. M ABERCROMBIEAnat Rec194621015608Yes
36042744274.0112.7112.7The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
36142674267.075.575.5Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
36242664266.0141.8141.8Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36342634263.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NASHBiochem J195313105648Yes
36442594259.0171.7171.7A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
36542504250.00.00.0Amino acid metabolism in mammalian cell cultures. H EAGLEScience195913675766Yes
36642374237.050.250.2Bone: formation by autoinduction. M R UristScience19655319761Yes
36742364236.0108.8108.8Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
36842354235.086.586.5The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
36942354235.0120.4120.4Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
37042254225.073.773.7Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
37142254225.080.680.6Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
37242224222.093.793.7Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
37342144214.099.499.4RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
37442104210.0100.6100.6The origins and the future of microfluidics. George M WhitesidesNature200616871203No
37542034203.0110.6110.6Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
37642024202.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DOLEJ Clin Invest195613286333Yes
37742014201.0175.0175.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
37841984198.086.486.4Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
37983964198.0217.2108.6Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
38083824191.0178.189.0Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
381125474182.3318.3106.1Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
38241664166.00.00.0The determination of enzyme inhibitor constants. M DIXONBiochem J195313093635Yes
38341604160.085.885.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
38441534153.0111.7111.7Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
38583054152.5193.296.6The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
38641494149.0127.8127.8Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
38741404140.0117.7117.7Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
38882794139.5177.188.5Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
389165054126.2366.391.6Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
39041254125.0144.1144.1KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
39141244124.0114.2114.2EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
39241164116.0100.4100.4Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
39341074107.0101.7101.7Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
394163064076.5573.7143.4Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
39540694069.0106.3106.3Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
39640664066.0133.4133.4Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
39781314065.5195.197.5The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
39840634063.069.269.2Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
399161854046.2722.7180.7fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
40040434043.091.291.2Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
401120914030.3322.6107.5Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
40240294029.0103.0103.0Integrins: a family of cell surface receptors. R O HynesCell19873028640No
40380484024.0151.475.7A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
40440224022.0106.9106.9What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
40540214021.081.981.9Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
40680384019.0197.298.6An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
40780354017.5151.175.5Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
40840034003.0127.8127.8Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
409119913997.0281.193.7Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
41039953995.082.082.0Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41179713985.5260.4130.2Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
41239793979.087.087.0Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
41339723972.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WATSONJ Biophys Biochem Cytol195813563554Yes
41439693969.0114.0114.0adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
41539653965.094.894.8Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
41679243962.0211.9106.0BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41739563956.0112.8112.8What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41839563956.0142.2142.2You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
41978503925.0218.9109.5Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
42039233923.0120.2120.2Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
42139233923.0119.4119.4genepop'007: a complete re-implementation of the genepop software for Windows and Linux. Francois RoussetMol Ecol Resour200821585727Yes
42239173917.064.064.0Disc Electrophoresis. I. Background And Theory. L ORNSTEINAnn N Y Acad Sci196414240533Yes
42339153915.091.791.7Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
424352033911.41046.3116.3STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
42539093909.0143.0143.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42639073907.076.176.1Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
42739013901.0117.7117.7Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
42839003900.0103.0103.0Graphene: status and prospects. A K GeimScience200919541989Yes
42938983898.0173.4173.4Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
43038963896.0116.3116.3Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
43138883888.0109.5109.5Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
432272103887.1926.3132.3limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
43338873887.090.490.4I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
43438863886.094.594.5How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
43538823882.0125.7125.7Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
43638813881.091.091.0Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
43738733873.088.588.5Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
43838623862.098.498.4The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
439347013855.7733.581.5Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
440115543851.3363.0121.0Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
441153833845.8619.5154.9IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
44238403840.0122.3122.3Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
44338323832.0102.3102.3Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
44438153815.077.577.5TGF-beta signal transduction. J MassagueAnnu Rev Biochem19989759503No
44576283814.0181.190.5Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
44638133813.098.998.9Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
44737993799.089.589.5Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrungerNature199218481394Yes
44837973797.079.279.2A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
44975913795.5175.487.7Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
45037913791.0120.1120.1No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
45137903790.097.597.5The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
45275633781.5163.681.8Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
45375563778.0224.8112.4Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
45437643764.091.091.0The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
45575253762.5378.8189.4Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
45637583758.065.165.1Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
45737533753.0107.2107.2Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
458112313743.7213.971.3Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
45937433743.066.066.0Somatic generation of antibody diversity. S TonegawaNature19836300689No
46037303730.0166.0166.0The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
461111873729.0258.586.2Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
46237113711.076.676.6Profile hidden Markov models. S R EddyBioinformatics19989918945No
46337043704.068.468.4A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
46437013701.0101.6101.6Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
46573633681.5268.5134.2The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
46673533676.5228.8114.4Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
467182993659.8655.6131.1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Ann Intern Med200919622511No
46836473647.0115.2115.2Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
46936473647.081.281.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
47036423642.0117.6117.6The Danish Civil Registration System. Carsten Bocker PedersenScand J Public Health201121775345Yes
47136413641.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MILLERPsychol Rev195613310704Yes
47272763638.0128.664.3Translating the histone code. T Jenuwein, C D AllisScience200111498575No
47336303630.071.171.1Mammalian neural stem cells. F H GageScience200010688783No
47436293629.084.184.1Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
475108773625.7252.784.2ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
47636243624.0166.6166.6Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
47736223622.080.080.0Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
47872423621.0365.5182.8Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H HUBEL, T N WIESELJ Physiol196214449617Yes
47972413620.5203.4101.7The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
48072393619.5168.984.5Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
48172273613.5410.0205.0The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
48236113611.055.055.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
48336113611.0108.2108.2Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
48436103610.0125.6125.6Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
48535993599.0106.3106.3Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
48635983598.0139.4139.4Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
48735953595.066.966.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
48835913591.0133.0133.0Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
48935903590.091.891.8Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
490107703590.0253.984.6Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
49135883588.099.899.8Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
49271703585.0137.768.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
49371623581.0208.3104.2The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
49435803580.0122.5122.5Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
49535753575.085.685.6The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49635713571.076.376.3Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
49771293564.5198.399.2Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
498106553551.71023.3341.1MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
49935513551.085.785.7The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
500389733543.0792.872.1Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
50170733536.5144.972.5A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
50235253525.057.057.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
50335183518.051.251.2The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WOESSNERArch Biochem Biophys196113786180Yes
504175853517.0493.798.7Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
505175763515.2612.3122.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, BMJ200919622551No
50670303515.0132.766.3The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50735143514.094.394.3Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
50835103510.0109.3109.3Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
50935023502.087.387.3Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
51034983498.077.277.2Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
51169913495.5208.7104.3Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51234853485.057.557.5Statistical estimations in enzyme kinetics. G N WILKINSONBiochem J196113785321Yes
51334823482.080.080.0The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
51469633481.5160.780.3Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
51534783478.0137.5137.5Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
516139063476.5777.0194.2Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
51734733473.069.569.5Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51834713471.094.594.5Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
51969403470.0182.991.5Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52069193459.5181.890.9Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
52134593459.082.382.3Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
52234573457.082.482.4Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
52369083454.0142.971.5Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
524103603453.3279.793.2GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hanzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
52534503450.065.465.4The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
52634483448.076.976.9Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
52734483448.0151.0151.0Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
52868783439.0162.381.2"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
52968693434.5171.885.9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
53068683434.0171.285.6TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
53134293429.091.591.5Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
53268573428.5190.695.3Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
53334263426.00.00.0Some factors in the interpretation of protein denaturation. W KAUZMANNAdv Protein Chem195914404936Yes
53434213421.070.170.1Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
535273013412.6578.772.3The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
53668223411.0212.7106.3Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
53768153407.5583.3291.6Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
53868093404.5204.3102.2Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
53933963396.068.768.7Protein folding and misfolding. Christopher M DobsonNature200314685248No
540101553385.098.232.7The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C GREENWOOD, W M HUNTER, J S GLOVERBiochem J196314097352Yes
54167693384.5211.7105.8Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
54233773377.0113.0113.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
54367433371.5217.6108.8Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54433713371.076.576.5Photoelectrochemical cells. M GratzelNature200111713540Yes
545101053368.3278.392.8Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
54667343367.0160.980.5In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
54733673367.068.568.5The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
54867163358.0271.1135.6GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
54967043352.0184.792.3mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
55033503350.0107.0107.0What is value in health care? Michael E PorterN Engl J Med201021142528Yes
55133483348.060.260.2Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
55233463346.0100.2100.2Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
55366903345.055.827.9The serial cultivation of human diploid cell strains. L HAYFLICK, P S MOORHEADExp Cell Res196113905658Yes
55433383338.067.967.9Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
55533273327.095.395.3Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
55633263326.087.987.9ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
55766433321.5103.151.5Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
55899403313.3277.592.5FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
55933073307.083.683.6Gene regulation by steroid hormones. M BeatoCell19892644044No
56033013301.078.078.0Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
56133013301.0157.2157.2Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
56233003300.074.874.8Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
56398983299.3472.8157.6Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
56432993299.046.246.2Equilibrium Ultracentrifugation Of Dilute Solutions. D A YPHANTISBiochemistry196414155091Yes
56565923296.0162.481.2Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
56632943294.051.451.4A Rationale And Test For The Number Of Factors In Factor Analysis. J L HORNPsychometrika196514306381Yes
56732883288.069.569.5Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
568131423285.5489.5122.4APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
56932853285.064.064.0STATs and gene regulation. J E DarnellScience19979287210No
57032823282.0111.1111.1The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
57198463282.0181.960.6Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
57265503275.0162.081.0Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
57332723272.0126.0126.0Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
57432703270.074.774.7The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57532673267.066.766.7TGFbeta in Cancer. Joan MassagueCell200818662538No
57632663266.0174.5174.5Obesity: global epidemiology and pathogenesis. Matthias BluherNat Rev Endocrinol201930814686No
57732593259.066.166.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
57832583258.0100.4100.4Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
57932573257.070.770.7Calcium signaling. David E ClaphamCell200718083096No
580130043251.0297.974.5Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
58165023251.0133.666.8Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
58232473247.093.193.1Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
58332413241.066.166.1Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
58432373237.086.786.7Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
58532313231.059.059.0Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
58696893229.7407.5135.8Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
58732293229.026.926.9Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LYONNature196113764598Yes
58832273227.0168.5168.5High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
58932143214.094.994.9The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
59032133213.066.366.3Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
59132123212.0110.1110.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
59232113211.0142.8142.8The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
59364223211.0110.255.1The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
59463953197.5296.1148.1Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
59531963196.0158.0158.0Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
59631963196.073.673.6Obesity as a medical problem. P G KopelmanNature200010766250No
597127783194.5359.890.0Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
59831903190.070.970.9T cell exhaustion. E John WherryNat Immunol201121739672No
59931903190.086.286.2Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
60063783189.0140.570.2Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
60195513183.7193.464.5Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
60231823182.0126.4126.4Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
60331793179.0105.4105.4Measurement of pain. E C HuskissonLancet19744139420Yes
60431783178.086.286.2The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
60563463173.0135.267.6MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
60631713171.074.374.3WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
60731673167.077.777.7The transforming growth factor-beta family. J MassagueAnnu Rev Cell Biol19902177343No
60831663166.073.373.3MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
60963183159.0162.281.1Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
610189483158.0895.1149.2DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
61131573157.068.668.6Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61263093154.5148.374.2Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
61363093154.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S REITMAN, S FRANKELAm J Clin Pathol195713458125Yes
61463053152.5131.365.7Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
61531433143.095.595.5A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
61631423142.00.00.0Diffusion-in-gel methods for immunological analysis. O OUCHTERLONYProg Allergy195813578996Yes
61731423142.0104.4104.4The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
61831233123.073.373.3Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
61993683122.7311.0103.7Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
62031123112.093.293.2Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
62192983099.3231.777.2Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
62292863095.3297.399.1Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
62330953095.0112.5112.5Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
62492803093.3213.671.2The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62561833091.5125.762.9Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
626123443086.0283.570.9Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
62792483082.7203.367.8TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
62830763076.059.659.6Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
62930763076.071.871.8Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
63030663066.084.784.7Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
63130643064.070.070.0Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
63230623062.047.547.5A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HAKOMORIJ Biochem196414135466Yes
63361183059.0191.495.7Extracellular vesicles: exosomes, microvesicles, and friends. Graca Raposo, Willem StoorvogelJ Cell Biol201323420871No
63461033051.5144.872.4Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
63530503050.092.392.3The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
63630483048.094.994.9An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
63730463046.029.529.5Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MITCHELLNature196113771349Yes
63860853042.5187.593.8Tissue engineering. R Langer, J P VacantiScience19938493529No
63930413041.055.055.0RNA interference. Gregory J HannonNature200212110901No
64091063035.3175.058.3Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
64130303030.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SELDINGERActa Radiol (Stockh)195313057644Yes
64230283028.073.773.7Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
64330273027.00.00.0The genetical structure of populations. S WRIGHTAnn Eugen195124540312Yes
64430263026.0128.8128.8Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
64560493024.5235.2117.6Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
64630243024.088.688.6SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
64730223022.066.166.1Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
64830213021.056.956.9Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64930123012.00.00.0A study of fixation for electron microscopy. G E PALADEJ Exp Med195214927794Yes
65030033003.070.470.4Structure and function of telomeres. E H BlackburnNature19911708110No
65129972997.056.656.6Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65229952995.0126.3126.3Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
65329942994.068.068.0Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
65429872987.057.457.4Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65559642982.0124.962.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
65629802980.091.091.0Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
65759512975.5180.290.1The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
65829752975.051.851.8The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
65989252975.0195.165.0Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
66029712971.074.774.7Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
66129702970.061.461.4Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
66229672967.083.083.0Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
66359312965.5176.988.5Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66429652965.0131.0131.0The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
66559292964.5195.297.6Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
66659202960.0199.899.9The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
66729582958.091.491.4Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
66888722957.3241.680.5Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
66959042952.0170.185.0Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
67029512951.061.961.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
67129492949.044.344.3Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
67229452945.072.772.7The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67358892944.5125.462.7Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
67429402940.057.857.8A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
67529392939.060.460.4Principles of CDK regulation. D O MorganNature19957877684No
67629342934.052.552.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
67729302930.075.775.7The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
67829262926.086.886.8Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
67958522926.0164.582.2Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
68058492924.5130.465.2Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
681175362922.7376.862.8Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
68229212921.073.773.7Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68329192919.048.748.7Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
68429152915.087.187.1Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
68529152915.068.568.5Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
68687382912.70.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J HAVEL, H A EDER, J H BRAGDONJ Clin Invest195513252080Yes
68758252912.5161.780.8Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
68829102910.070.770.7Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
68958072903.5249.4124.7Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
69028982898.095.395.3Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
69128982898.077.377.3Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
69257942897.0154.477.2Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69328942894.00.00.0Notes on sugar determination. M SMOGYIJ Biol Chem195214938350Yes
69428892889.048.948.9A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GEHANBiometrika196514341275Yes
69557762888.0115.357.6Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
69628832883.0128.4128.4Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
69728822882.060.760.7Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
69828802880.083.783.7Separation of leukocytes from blood and bone marrow. Introduction. A BoyumScand J Clin Lab Invest Suppl19685707208Yes
69957542877.0194.797.3A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
70028742874.093.393.3Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
70128732873.050.650.6One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
70257442872.0111.255.6Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
70357382869.0172.986.5Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
70428662866.072.372.3Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
70528612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SCHNEIDERJ Biol Chem194521005736Yes
70628542854.0111.6111.6What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
70785542851.3246.882.3Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
70828472847.093.393.3A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
70928462846.082.782.7Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
71028452845.00.00.0A study of the adrenotropic receptors. R P AHLQUISTAm J Physiol194818882199Yes
71156892844.5147.073.5Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
71256832841.50.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D WATSON, F H CRICKNature195313054692Yes
71328392839.096.596.5Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
71456692834.5203.0101.5Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
71584982832.7222.874.3Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
71628302830.064.064.0Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71756562828.0172.986.5Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
71856552827.5158.879.4Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
71928272827.0110.8110.8A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
72028212821.056.656.6Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
72128202820.063.963.9Memory--a century of consolidation. J L McGaughScience200010634773No
72228192819.065.365.3Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
72356382819.0134.267.1Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
72428172817.068.668.6Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
72556262813.0134.967.5Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
72656202810.0132.466.2Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
72728102810.0111.8111.8Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
72856182809.0125.562.8Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
72928082808.064.864.8An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
73056102805.0151.976.0The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
73156072803.5315.2157.6A modified uronic acid carbazole reaction. T BITTER, H M MUIRAnal Biochem196213971270Yes
73256032801.5178.389.2The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
73327972797.082.982.9Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
734111852796.2321.080.2Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
73527962796.052.952.9The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
73627912791.023.623.6Satellite cell of skeletal muscle fibers. A MAUROJ Biophys Biochem Cytol196113768451Yes
73755802790.076.038.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G MARTIN, B N AMESJ Biol Chem196113767412Yes
73827882788.061.861.8Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
73983602786.7331.8110.6Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
74027852785.087.887.8Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
74127852785.060.760.7Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
742111342783.5293.073.2Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
74327832783.065.065.0P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
74455652782.5167.383.7Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
74527822782.066.266.2A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
746111252781.2259.364.8Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
74727802780.061.261.2Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
74883392779.7212.370.8Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
749111092777.2320.880.2Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
75027772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
75127762776.061.761.7Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
75255482774.0159.779.8The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
75327692769.060.260.2On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
75483012767.0207.169.0Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
75527612761.0143.8143.8Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
75627612761.097.897.8Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
75727612761.0107.4107.4Metazoan MicroRNAs. David P BartelCell201829570994No
75827602760.074.974.9Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
75927582758.0101.6101.6Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
76027552755.065.665.6Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
76127522752.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SVENNERHOLMBiochim Biophys Acta195713436486Yes
76255012750.5108.954.5Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J SILNESS, H LOEActa Odontol Scand196414158464Yes
76327462746.067.767.7Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
76454872743.5216.6108.3A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
76554812740.5107.753.9High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
76627402740.069.769.7Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
76727372737.0108.3108.3Deep learning in neural networks: an overview. Jurgen SchmidhuberNeural Netw201525462637No
76854702735.0109.754.9MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
76954612730.5123.861.9A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
77081812727.0236.278.7Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
77181712723.7194.664.9RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
77254382719.0136.668.3UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
77354372718.5118.859.4Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
77427172717.050.050.0Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
77581502716.7174.358.1Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
77627162716.073.773.7Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
77754322716.0141.971.0Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
77827162716.055.155.1Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
77927152715.056.656.6Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
78054292714.5102.651.3Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
781108352708.8226.456.6Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
78227072707.058.058.0The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
78354132706.5233.0116.5Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
78427062706.051.351.3Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
78527012701.082.882.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
78680932697.7402.0134.0SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
78726942694.050.550.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
78853842692.0131.165.5ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
78926912691.074.474.4Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
79053782689.0130.465.2A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
79126862686.066.366.3A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
79226862686.081.581.5Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
79326842684.063.663.6Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
79453592679.5172.386.2The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
79580372679.0194.764.9MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
79653562678.0155.377.7SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
79726762676.061.561.5Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
798427782673.61296.981.1Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
79980152671.7320.8106.9Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
80026702670.095.095.0UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
80153392669.572.236.1A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
80226642664.055.655.6Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
80326642664.064.264.2MYC on the path to cancer. Chi V DangCell201222464321No
80426632663.070.370.3Dominant forces in protein folding. K A DillBiochemistry19902207096No
80526622662.076.976.9Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
80626612661.066.066.0The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
80726602660.059.259.2Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
80826562656.072.772.7Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
80926522652.0106.4106.4The biology of oxygen radicals. I FridovichScience1978210504Yes
81053042652.0110.955.5Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
81126492649.055.355.3Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
812105812645.2263.265.8GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
81352902645.0138.269.1Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
81452872643.5166.083.0PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
81552802640.0126.663.3The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
81652712635.5169.985.0Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
81726262626.086.386.3Working memory. A BaddeleyScience19921736359No
81852472623.5116.658.3Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
81952382619.0160.480.2The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
82052362618.00.00.0Some quantitative uses of drug antagonists. O ARUNLAKSHANA, H O SCHILDBr J Pharmacol Chemother195913651579Yes
82126162616.0107.4107.4The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
82226142614.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
82352262613.0180.090.0A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
82426112611.035.435.4The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
82526102610.056.556.5The inflammatory reflex. Kevin J TraceyNature200212490958No
82626062606.0115.3115.3Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82726042604.075.475.4PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
82826012601.0165.7165.7User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
82926002600.055.055.0G1 phase progression: cycling on cue. C J SherrCell19947954821No
83025992599.070.270.2Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
83125982598.080.580.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
83251962598.0102.051.0Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
83351932596.5111.555.8Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
83477602586.7215.171.7Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
83525862586.081.281.2Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
83625822582.073.173.1Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
83751612580.5151.175.5Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
83825802580.061.361.3Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
83925782578.061.461.4Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
84025762576.071.571.5Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
84177212573.7201.167.0trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni GabaldonBioinformatics200919505945Yes
84225712571.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PORTERBiochem J195914434282Yes
84325692569.0120.5120.5The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
84451332566.5139.069.5The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
84525642564.0130.8130.8The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
84625622562.0103.5103.5The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
84725592559.074.674.6Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
84851162558.0277.0138.5A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
84951162558.0218.4109.2The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
850102222555.5215.653.9MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
85125552555.0126.4126.4The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BOYDENJ Exp Med196213872176Yes
85225532553.068.568.5Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
85351042552.0147.573.8Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
85425512551.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SMITHIESBiochem J195513276348Yes
85525482548.067.367.3TGFβ signalling in context. Joan MassagueNat Rev Mol Cell Biol201222992590No
85625472547.050.850.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
85725452545.076.776.7A two process model of sleep regulation. A A BorbelyHum Neurobiol19827185792Yes
85850812540.5143.371.7Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
85950712535.5121.560.8Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
86025342534.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FITTSJ Exp Psychol195413174710Yes
86125332533.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
86250612530.570.835.4Periodontal Disease In Pregnancy. I. Prevalence And Severity. H LOE, J SILNESSActa Odontol Scand196314121956Yes
86350612530.5132.766.3Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86425282528.080.180.1Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
86550552527.5131.165.5Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
86650432521.5149.274.6Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
86725192519.082.582.5Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
86825192519.044.144.1Wnt signaling and cancer. P PolakisGenes Dev200010921899No
86925182518.076.976.9Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
87050332516.596.148.0CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
87150252512.5130.465.2Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
87225102510.057.057.0Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
87350102505.0162.181.0Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rossello-MoraProc Natl Acad Sci U S A200919855009Yes
87450002500.0161.680.8Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
87525002500.050.750.7Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
87625002500.070.070.0Hazards of heavy metal contamination. Lars JarupBr Med Bull200314757716No
87724992499.062.662.6Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
87824942494.060.960.9The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
87949852492.5180.990.5Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
88024922492.044.244.2Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
881124442488.8280.356.1Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
88224882488.052.252.2A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
88324832483.052.552.5Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
88424832483.062.562.5Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
88524812481.043.743.7Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
88624802480.076.576.5Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
88724792479.095.295.2Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
88849572478.593.646.8The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
88924762476.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LENNOXVirology195513267987Yes
89024752475.0112.1112.1Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
89124752475.059.759.7Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
89224752475.0130.2130.2Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
89349492474.5118.859.4Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
89449482474.0132.266.1Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
89549422471.095.047.5Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
89624702470.070.370.3Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
89774052468.3156.352.1The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
89824672467.0129.1129.1Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
89949292464.5121.160.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
90098562464.0210.752.7Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
90149272463.5105.052.5AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
90224622462.047.347.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
90324612461.053.253.2Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
90424582458.028.128.1Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HIGUCHIJ Pharm Sci196314088963Yes
90524582458.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BERTANIJ Bacteriol195114888646Yes
90698292457.2194.248.5WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
90724552455.058.658.6Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
90824542454.078.978.9Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
90924492449.064.964.9Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
91024472447.053.853.8Social controls on cell survival and cell death. M C RaffNature19921557121No
91124462446.062.262.2Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
91224442444.059.459.4The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
91324412441.064.264.2Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
91448822441.0105.652.8Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
91524352435.062.062.0The importance of selenium to human health. M P RaymanLancet200010963212No
91624312431.057.657.6The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
91724302430.067.667.6Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
91872872429.0221.373.8Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
91924262426.074.274.2Human error: models and management. J ReasonBMJ200010720363Yes
92024262426.062.462.4Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
92148502425.0109.254.6Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
92248502425.0112.156.0Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
92348482424.0174.787.3Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
92448442422.0135.667.8Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
92524212421.051.951.9Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
92624192419.00.00.0Muscle structure and theories of contraction. A F HUXLEYProg Biophys Biophys Chem195713485191Yes
92724182418.049.149.1Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
92824172417.054.754.7A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
92948332416.5126.363.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
93024152415.055.755.7Specification of cerebral cortical areas. P RakicScience19883291116No
93124152415.049.649.6NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
93248232411.597.448.7New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
93324082408.062.762.7A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
93424072407.080.380.3Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JobsisScience1977929199Yes
93548112405.590.945.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassagueCell200312809600No
93672112403.7284.894.9The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
93748062403.0175.087.5The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
93896052401.2448.0112.0The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
93948022401.0133.967.0Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
94048002400.0168.984.5Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
941191832397.9736.892.1The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver GlocknerNucleic Acids Res201323193283Yes
94271902396.769.323.1On The Nature Of Allosteric Transitions: A Plausible Model. J MONOD, J WYMAN, J P CHANGEUXJ Mol Biol196514343300Yes
94323962396.074.374.3Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
94447902395.0124.662.3Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
94547872393.5117.959.0Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
94623922392.0127.1127.1The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
94723872387.056.156.1Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
94823822382.047.947.9The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
94947602380.0103.151.5Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
95023792379.097.897.8The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
95147552377.5118.659.3Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
95223772377.0141.1141.1Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
95371312377.0203.167.7The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
95447512375.588.944.5A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
95571122370.7192.364.1Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
95647372368.596.348.1Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
95723662366.078.878.8A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
95847262363.0137.768.8Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
95923612361.045.445.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
96094262356.5216.954.2Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
96123542354.057.857.8A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
96223542354.040.140.1Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
96323522352.091.291.2Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
96470482349.3206.868.9Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
96523492349.051.751.7The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
96623492349.042.642.6Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96746962348.077.438.7On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
96823482348.091.191.1Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
96923412341.068.868.8Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
97023402340.065.665.6Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
97146802340.087.944.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
97246802340.0115.958.0The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
97323392339.056.056.0The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
97446722336.0117.158.5The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
97546712335.5102.251.1Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
97623352335.043.043.0Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
97723342334.050.150.1Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
97823322332.084.084.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
97946602330.0114.857.4A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
98023282328.071.971.9Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
98123252325.052.252.2Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
98223252325.071.871.8Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
98346492324.5152.676.3Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
98423232323.064.564.5Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
98546462323.0191.095.5The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
98623232323.062.062.0The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
98746432321.5110.255.1Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
98846382319.076.638.3Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
98946372318.5128.264.1Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
99023162316.085.685.6Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
99123162316.056.256.2Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
99223152315.056.856.8RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
99323122312.048.348.3Theta oscillations in the hippocampus. Gyorgy BuzsakiNeuron200211832222No
99469242308.0138.746.2EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
99523082308.066.266.2Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
99646092304.569.234.6High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
99746072303.590.945.5Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
99823022302.056.556.5Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
99923002300.049.549.5A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
100068982299.3265.088.3Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
100168982299.3245.181.7Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
100245912295.5109.254.6Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
100322952295.0100.7100.7International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
100422932293.068.868.8A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
100545802290.0163.881.9mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
100622892289.092.092.0Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
100745772288.5189.394.7The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
100822872287.069.169.1Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
100922862286.068.668.6Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
101022862286.047.547.5Complement. First of two parts. M J WalportN Engl J Med200111287977No
101145722286.0110.355.1Building better batteries. M Armand, J-M TarasconNature200818256660No
101268552285.0156.552.2APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
101322842284.075.775.7Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
101422842284.045.245.2SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
101545602280.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B SCOVILLE, B MILNERJ Neurol Neurosurg Psychiatry195713406589Yes
101622802280.060.760.7Hybrid porous solids: past, present, future. Gerard FereyChem Soc Rev200818197340Yes
101722802280.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PENNESJ Appl Physiol194818887578Yes
101822792279.054.154.1Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
101922792279.060.660.6Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
102022782278.054.954.9Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
102145552277.5161.480.7ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
102222772277.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A CLAUSSActa Haematol195713434757Yes
102345512275.5143.571.8Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
102445512275.584.142.0SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
102522752275.056.456.4Descending control of pain. Mark J MillanProg Neurobiol200212034378No
102622722272.066.566.5Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
102745382269.0241.0120.5OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
102845372268.5128.264.1Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
102945332266.586.543.2Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
103022652265.050.150.1Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
103145282264.089.244.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
103222642264.056.356.3What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
103345252262.5121.360.6Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
1034248552259.5596.954.3PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
103522592259.0138.4138.4Application of a microtechnique to viral serological investigations. J L SEVERJ Immunol196213910995Yes
103645182259.0198.599.2Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
103722572257.051.251.2Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
103822572257.076.876.8Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
103922542254.061.561.5Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
104022542254.048.348.3Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
104145072253.538.219.1A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
104222532253.052.952.9Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
104367522250.7210.670.2Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris Sherman, Hepatology201121374666No
104445012250.5128.464.2Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
104522502250.048.048.0Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
104644992249.5102.351.1A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
104722482248.063.063.0Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
104822472247.060.960.9Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
104922462246.057.657.6The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
105022462246.0116.0116.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
105122462246.054.954.9Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
105222462246.052.652.6Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
105322462246.073.373.3Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
105422452245.076.776.7Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
105544852242.5102.651.3Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
105622422242.048.748.7Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
105722412241.0110.4110.4Subjective well-being. E DienerPsychol Bull19846399758No
105889642241.0286.571.6Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
105922392239.048.948.9The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
106044742237.099.049.5The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
106122372237.045.245.2Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
106222362236.064.564.5Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
106322352235.065.665.6Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
106422352235.095.495.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
1065134072234.5295.549.2NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
106644632231.5139.869.9A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
106722312231.052.152.1Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
106844622231.0123.661.8Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
106922302230.0111.5111.5Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
107022282228.052.252.2Mechanisms and genes of cellular suicide. H StellerScience19957878463No
107144522226.098.049.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
107222252225.053.953.9Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gokhan S HotamisligilCell201020303879No
107388842221.0342.585.6jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramon Doallo, David PosadaNat Methods201222847109Yes
107422182218.072.272.2A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
107522162216.039.639.6NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
107622142214.091.591.5A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
107722132213.076.876.8International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
107844252212.593.446.7The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
107966292209.7178.959.6Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdottir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
108022092209.067.467.4Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
108122072207.078.778.7Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
108244142207.083.441.7Network biology: understanding the cell's functional organization. Albert-Laszlo Barabasi, Zoltan N OltvaiNat Rev Genet200414735121No
108344112205.593.947.0Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
108422052205.056.456.4Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
108522052205.082.882.8Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
108622042204.048.348.3Chemokines. B J RollinsBlood19979242519No
108722012201.060.960.9phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
108822012201.078.078.0Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
108921992199.059.159.1Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
109043962198.094.047.0Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
109121952195.051.351.3Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
109243882194.0118.759.4Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
109321932193.048.748.7Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
109465762192.0188.562.8Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
109565752191.7165.955.3GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
109643822191.0153.276.6ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
109721902190.093.693.6Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
109843782189.0147.373.7Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
109965652188.3118.639.5Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
110043762188.080.540.2The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
110121812181.046.446.4Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
110243512175.5132.366.2Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
110321742174.058.958.9Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
110421732173.085.185.1Perception of risk. P SlovicScience19873563507Yes
110521732173.051.651.6Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
110643462173.0165.983.0Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
110786892172.2281.470.3Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
110821722172.068.768.7The Gingival Index, the Plaque Index and the Retention Index Systems. H LoeJ Periodontol19675237684Yes
110943422171.0116.058.0EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
111021702170.065.065.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
111143362168.0103.151.5Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
111221672167.050.850.8Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
111321662166.041.541.5Protein modules and signalling networks. T PawsonNature19957531822No
111421652165.069.569.5Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
111586562164.0200.950.2Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
111643262163.082.341.1Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
111743262163.0170.185.0The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
111821612161.049.549.5Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
111921612161.066.266.2Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
112043182159.0101.150.5Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
112143132156.5189.494.7Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
112243132156.594.247.1Liver fibrosis. Ramon Bataller, David A BrennerJ Clin Invest200515690074No
112321562156.042.542.5Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
112421562156.066.866.8The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
112543092154.598.449.2Neuronal oscillations in cortical networks. Gyorgy Buzsaki, Andreas DraguhnScience200415218136No
112621542154.058.758.7Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
112721532153.030.530.5Sedimentation Studies Of The Size And Shape Of Dna. F W STUDIERJ Mol Biol196514290352Yes
112821522152.042.642.6Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
112943042152.0106.753.4Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
113086072151.8203.851.0Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
1131172102151.2481.760.2The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
113221512151.040.640.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
113321492149.049.749.7Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
113442972148.5104.252.1Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
113521472147.064.864.8Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
113664382146.0129.143.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
113721462146.00.00.0On respiratory impairment in cancer cells. O WARBURGScience195613351639Yes
113821462146.041.241.2Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
113921462146.00.00.0A new specific color reaction of hexuronic acids. Z DISCHEJ Biol Chem194720281638Yes
114042892144.5121.961.0Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
114142892144.5231.2115.6ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
114264302143.3145.848.6MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WuthrichJ Mol Graph19968744573Yes
114364292143.0204.568.2Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
114442862143.071.035.5A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H VENABLE, R COGGESHALLJ Cell Biol196514287192Yes
114521412141.054.654.6Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
114664152138.3207.369.1Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
114721382138.064.264.2The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
114842762138.0159.479.7Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
114964132137.7267.889.3Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
115042752137.535.417.7Genetic regulatory mechanisms in the synthesis of proteins. F JACOB, J MONODJ Mol Biol196113718526Yes
115142732136.5181.690.8The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
115221362136.041.941.9Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
115321352135.043.843.8Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
115421352135.041.041.0DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
115542692134.5123.361.6Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
115621342134.058.558.5Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
115742672133.5110.755.4The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
115885242131.0315.278.8The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerstromBr J Addict19911932883Yes
115963902130.0203.667.9Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
1160106452129.0330.266.0The hallmarks of aging. Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
116142552127.5121.660.8Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
116221262126.050.450.4Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
116321252125.044.144.1Mammalian G1 cyclins. C J SherrCell19938513492No
116421252125.042.942.9Molecular bases for circadian clocks. J C DunlapCell19999988221No
116542492124.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F BEERS, I W SIZERJ Biol Chem195214938361Yes
116621232123.044.644.6Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
116742442122.082.541.2Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
116863612120.3205.568.5Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
116921202120.034.334.3Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AMINOFFBiochem J196113860975Yes
117021172117.083.483.4A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
1171148192117.0320.245.7Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
117242342117.084.642.3'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
117321162116.080.680.6Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
117442312115.5155.978.0Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
117521142114.065.565.5Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
117642272113.582.241.1Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
117721122112.060.760.7The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
117821112111.049.349.3Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
117921102110.098.998.9Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
118063302110.0182.660.9Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
118142192109.5105.953.0Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
118221062106.064.864.8Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
118342052102.5117.258.6Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
118442032101.5119.259.6Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
1185147062100.9416.559.5AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
118621002100.047.247.2DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
118741992099.5132.566.2Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
118841992099.5178.689.3A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
118920992099.047.147.1The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
119041962098.0281.9140.9WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
119141942097.080.240.1The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
119220962096.040.540.5DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
119320962096.078.478.4Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
119441872093.5150.575.2The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
119520912091.073.073.0Selenium and human health. Margaret P RaymanLancet201222381456No
119683632090.8268.167.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
119720892089.040.240.2Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
119841782089.0148.174.0Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
119920892089.040.140.1Method For Assay Of Intestinal Disaccharidases. A DAHLQVISTAnal Biochem196414106916Yes
120020882088.050.350.3Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
120141762088.0140.570.2The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
1202146132087.6321.245.9Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
120320872087.056.756.7Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
1204166912086.4392.049.0Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
120520862086.074.274.2Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
120620862086.042.542.5TRP channels as cellular sensors. David E ClaphamNature200314654832No
120720852085.052.452.4The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
120820852085.039.539.5Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
120941652082.599.449.7Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
121041632081.5227.6113.8Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
121120812081.065.765.7Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
121220802080.059.359.3ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
121320792079.043.243.2The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
121441562078.0110.755.4New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
121520782078.038.438.4Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
121620772077.048.648.6Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
121720772077.00.00.0Cognitive maps in rats and men. E C TOLMANPsychol Rev194818870876Yes
121820762076.047.047.0Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
121920752075.039.039.0CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
122041482074.0145.672.8The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
122120732073.057.257.2Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
122220722072.036.336.3Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SKOUPhysiol Rev196514337569No
122320712071.042.342.3G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
122420712071.064.664.6Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
122520682068.063.263.2Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
122641332066.587.843.9ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
122720642064.051.751.7Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
122841252062.595.747.9Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
122941252062.5139.169.5The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683Yes
123041242062.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R DULBECCO, M VOGTJ Exp Med195413130792Yes
123141232061.585.542.8A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
123261842061.3229.076.3Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
123361812060.3197.265.7AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
123420592059.018.618.6The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W CLELANDBiochim Biophys Acta196314021667Yes
123520582058.051.451.4From sensation to cognition. M M MesulamBrain19989648540No
123620562056.046.046.0Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
123720552055.047.447.4Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
123820542054.084.184.1A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
123920532053.023.923.9Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LITTLEFIELDScience196414168277Yes
124041032051.588.744.4Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
124141022051.0100.050.0Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
124261512050.3206.668.9Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
124320502050.034.634.6ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
124420502050.0100.9100.9Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NEELAm J Hum Genet196213937884Yes
124520502050.046.446.4The genetics of ageing. Cynthia J KenyonNature201020336132No
124641002050.0126.363.1Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
124720482048.067.467.4The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
124840912045.5109.854.9Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
124920452045.058.758.7Protein oxidation and aging. E R StadtmanScience19921355616No
125040872043.5110.055.0Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
125140872043.5125.362.6Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
125240792039.589.945.0The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
125381562039.0223.155.8Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
125420382038.034.634.6Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
125520382038.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A SHOLLJ Anat195313117757Yes
125620372037.056.956.9Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
125720362036.055.455.4Introduction and General Overview of Cyclodextrin Chemistry. Jozsef SzejtliChem Rev199811848947Yes
125840712035.592.246.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
125940712035.578.339.1A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelieresJ Microsc200617210054Yes
1260183122034.7567.563.1The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
126140672033.5139.269.6Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
126240662033.0101.850.9Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
126340652032.597.848.9Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
126420322032.047.247.2Calcium signaling. D E ClaphamCell19957834745No
126520322032.052.752.7Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
126620312031.063.063.0Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
126720302030.051.851.8Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
126820302030.058.458.4Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
126940602030.0116.858.4LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
127020242024.036.836.8In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
127120242024.050.550.5Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
127220242024.083.883.8The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
127320242024.059.659.6Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
127420232023.052.652.6Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
127520222022.078.378.3Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
127620202020.088.588.5A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
127720202020.070.070.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
127820202020.041.641.6The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
127940342017.098.249.1Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
128020172017.050.450.4Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
128120162016.038.038.0Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
128220162016.038.938.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
128380612015.2186.746.7Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
128420142014.043.543.5Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
128520142014.042.742.7A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
128620142014.00.00.0Antigen-antibody reactions in gels. O OUCHTERLONYActa Pathol Microbiol Scand194918143039Yes
128740272013.585.342.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
128820132013.059.459.4Social relationships and health. Sheldon CohenAm Psychol200415554821No
128920132013.045.345.3The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
129020102010.041.041.0XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
129120102010.063.463.4Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
129260282009.3107.435.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
129320092009.039.739.7Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
129420092009.051.551.5What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
129540142007.086.543.2The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
129640112005.5157.578.8Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
129720052005.076.576.5Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
129820042004.043.743.7Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
129960102003.3151.750.6Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
130020032003.054.854.8The biology of interleukin-6. T KishimotoBlood19892473791No
130140062003.0121.560.8Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
130240052002.5101.750.9Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
130320022002.034.634.6Signaling--2000 and beyond. T HunterCell200010647936No
130420012001.043.343.3Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
130540002000.090.945.5Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
130639981999.077.438.7An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
130719981998.022.722.7A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
130839951997.597.949.0ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
1309139791997.0371.253.0BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
131019971997.071.071.0AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
131139931996.5107.753.9Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
131239911995.589.644.8PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schuttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
131339911995.5121.360.6Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
131459851995.0247.082.3Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graca RaposoNat Rev Mol Cell Biol201829339798No
131519941994.052.652.6Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
131619941994.074.074.0α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
131719931993.040.340.3Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
131819931993.051.551.5Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
131939841992.094.247.1Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
132019921992.043.743.7The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
132119911991.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
132279561989.0307.977.0A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
132339761988.0137.168.5The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
132439741987.096.448.2Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
132539741987.0116.758.4The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
132619871987.052.252.2The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
132719861986.059.059.0The inverse care law. J T HartLancet19714100731Yes
132819851985.059.059.0The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
132939701985.0114.457.2New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
133019851985.039.939.9Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
133139701985.0110.755.4The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
133299221984.4225.045.0Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
1333119061984.3338.656.4Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
133439671983.559.629.8Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R MORRISON, L M SMITHJ Lipid Res196414221106Yes
133519831983.050.850.8The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
133659431981.0170.856.9Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
1337118791979.8338.456.4New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
133839541977.0132.766.3Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
133919771977.039.139.1The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
134019771977.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R STEELEAnn N Y Acad Sci195913833973Yes
134139541977.0102.351.1Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
1342118611976.8269.845.0GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
134319761976.016.016.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
134459271975.7345.4115.1An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
134519751975.070.770.7Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
134619751975.041.441.4Exploring complex networks. S H StrogatzNature200111258382No
134739501975.094.547.2The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
134819731973.048.548.5High-speed scanning in human memory. S SternbergScience19665939936Yes
134919721972.038.738.7Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
135039441972.0106.253.1The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
135159161972.0258.586.2Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
135219701970.00.00.0On estimating the relation between blood group and disease. B WOOLFAnn Hum Genet195514388528Yes
135359071969.0194.164.7Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
135419691969.055.355.3The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
135519691969.055.855.8Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
135639371968.579.940.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
135719681968.057.657.6Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
135839361968.0122.261.1Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
135919681968.066.566.5Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
136078711967.8262.765.7Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
136119671967.048.148.1Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
136239331966.5126.163.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
136339321966.086.243.1Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
136458951965.0148.349.4Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
136519651965.044.844.8The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
136639291964.573.536.8Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
136719621962.055.755.7Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
136839241962.0173.086.5Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
136919601960.045.745.7Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
137039151957.5140.470.2Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
137119571957.063.363.3Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
137219571957.057.457.4Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
137319551955.061.861.8The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
137419551955.042.442.4Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
137519551955.056.956.9Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
137619541954.050.650.6Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
137719541954.069.369.3The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
137819531953.040.240.2The etiology of chondromalacia patellae. R E OUTERBRIDGEJ Bone Joint Surg Br196114038135Yes
137919521952.042.042.0Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
138019521952.051.551.5Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
138139031951.576.638.3A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
138278031950.8350.587.6Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
138319501950.070.870.8Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
138439001950.065.532.8Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
138519491949.077.977.9Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
138619491949.055.155.1Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
138738951947.584.442.2Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
138819471947.064.064.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
138919461946.042.642.6Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
139019451945.075.675.6Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
139119451945.054.054.0Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
139238901945.069.334.6Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
139319451945.045.745.7Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
139438881944.080.140.0Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
139558291943.0119.439.8Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
139619431943.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BOYDENJ Exp Med195114803635Yes
139777691942.2323.580.9An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
139838821941.0102.851.4Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
139938811940.588.044.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
140019401940.045.645.6The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
140119401940.040.940.9Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
140219391939.033.733.7The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
140338751937.587.143.5The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
140419371937.063.763.7Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
1405135571936.7473.667.7Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
140619361936.057.357.3The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
140738691934.5102.651.3Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
140819341934.053.353.3Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
140919341934.051.651.6Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141019331933.064.164.1Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
141119321932.061.761.7Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
141219321932.073.273.2Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
141319311931.046.746.7Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
141419311931.061.661.6Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
141519311931.041.441.4Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
141619301930.050.250.2DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
141738601930.0279.0139.5Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
141877161929.0187.346.8p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
141957851928.3151.850.6Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RohlMol Biol Evol199910331250Yes
1420134891927.0383.754.8The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, Lancet200718064739Yes
142157691923.0125.241.7Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
142238451922.5123.561.8miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
142338421921.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J VOGEL, D M BONNERJ Biol Chem195613278318Yes
142419201920.039.839.8The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
142519191919.039.839.8A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
142619191919.046.746.7DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
142719191919.050.850.8Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
142857541918.0117.239.1Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
142919171917.068.068.0Antibiotics in the aquatic environment--a review--part I. Klaus KummererChemosphere200919185900No
143019151915.046.446.4Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
143138291914.5101.850.9Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
143238281914.0127.563.8Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
143319131913.076.176.1Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
143419111911.054.854.8Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
143519091909.053.553.5In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
1436152711908.9487.560.9GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, BMJ200818436948Yes
143738161908.0140.370.2A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
143857241908.0285.995.3Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
143957231907.7337.8112.6Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
144057231907.7168.456.1Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
144138151907.584.842.4Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
144219061906.051.251.2A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
144357171905.7116.738.9A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
144438111905.5107.453.7How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
144538101905.0189.794.8Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
144619051905.055.455.4Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
144719041904.042.542.5Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
144819041904.043.743.7Tricine-SDS-PAGE. Hermann SchaggerNat Protoc200617406207Yes
144919021902.041.041.0The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
145038021901.088.344.1Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
145119001900.050.350.3Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
145219001900.00.00.0The oxidation of ribonuclease with performic acid. C H HIRSJ Biol Chem195613319283Yes
145338001900.0122.661.3Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
145419001900.0175.0175.0Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Brent R StockwellCell202235803244No
145575981899.5199.249.8Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
145618981898.087.587.5A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
145718981898.051.451.4Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
145818941894.037.437.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
145918941894.049.849.8Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
146018941894.075.475.4Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
146137871893.589.144.5The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
146294661893.2441.388.3ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
146375711892.8251.963.0Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
146456781892.7125.041.7A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
146518911891.037.537.5Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
146637801890.0112.356.1An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
146718901890.082.782.7Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
146818891889.061.461.4Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
146918881888.076.076.0Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
147018881888.019.719.7Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
147118871887.058.658.6The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
147275471886.8210.852.7The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
147337721886.076.738.4Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
147418861886.035.235.2Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
147537711885.585.442.7The Fas death factor. S Nagata, P GolsteinScience19957533326No
147694231884.6331.466.3UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
147737681884.077.338.6Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
147818831883.043.743.7The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
147918831883.037.337.3Points of control in inflammation. Carl NathanNature200212490957No
148018831883.036.736.7Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
148118831883.064.664.6The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
148237661883.0113.656.8Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
148337651882.5132.766.3Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
148437631881.599.349.6Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
148518811881.085.885.8Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
148637611880.5103.551.8CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
148718801880.036.336.3MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
148818801880.049.849.8The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
148918771877.053.953.9An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
149056291876.3139.246.4Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
149118761876.044.644.6Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
149218751875.033.833.8Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
149318751875.046.246.2The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
149493711874.2212.242.4Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
149574921873.0178.944.7Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
149618711871.033.633.6Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
149718711871.057.257.2The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
149818691869.035.935.9The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
149918691869.047.647.6Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
150037371868.5100.550.2Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
150118681868.070.470.4Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
150218671867.048.448.4Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
150337341867.077.438.7Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
150418671867.039.039.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
150518671867.033.633.6Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
150637331866.575.137.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
150737321866.0120.160.0Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
1508242461865.1902.869.4Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, Genet Med201525741868No
150937281864.0189.394.7Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
151037261863.0104.652.3Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
151118621862.057.757.7Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
151218621862.045.845.8Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151318611861.066.366.3Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
1514148861860.8416.052.0Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
151537191859.584.042.0Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
151618591859.043.043.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
151718591859.042.042.0The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
151818581858.052.152.1Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
151918581858.042.242.2Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
152037161858.077.638.8Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
152118561856.017.917.9A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A ROBINSONIEEE Trans Biomed Eng196314121113Yes
152218551855.044.144.1Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
152318551855.063.463.4The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
152455651855.0102.834.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
152518551855.036.636.6Protein homology detection by HMM-HMM comparison. Johannes SodingBioinformatics200515531603Yes
152637031851.585.342.6Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
152755541851.3142.647.5A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
152892521850.4235.847.2Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
152918501850.037.637.6Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
153018491849.041.141.1DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
153118491849.042.242.2Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
153218491849.041.841.8The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
153336971848.5142.571.2Assays of glutathione peroxidase. L Flohe, W A GunzlerMethods Enzymol19846727659Yes
153473931848.2340.285.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
153518471847.088.688.6DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
153618461846.054.054.0Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
153718461846.052.852.8A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
153818451845.041.941.9Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
153936881844.052.926.4Immunoassay of insulin with insulin-antibody precipitate. C N HALES, P J RANDLEBiochem J196313952078Yes
154018431843.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SIMPSONJ Neurol Neurosurg Psychiatry195713406590Yes
154136861843.095.747.9The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
154236851842.5131.465.7Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
154336851842.585.142.5Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
154418421842.050.450.4Protein denaturation. C TanfordAdv Protein Chem19684882248No
154536841842.094.747.4A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
154636831841.5113.756.9Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
154718411841.043.143.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
154818411841.050.150.1Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
154918401840.045.345.3Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
155018401840.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SKOUBiochim Biophys Acta195713412736Yes
155118401840.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
155218401840.080.280.2Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
155318381838.067.467.4Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
155418371837.067.367.3Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
155518351835.060.060.0Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
155618351835.044.044.0Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
155718351835.043.443.4Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
155855031834.3120.640.2Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
155918341834.059.459.4The crisis in antibiotic resistance. H C NeuScience19921509257No
1560110021833.7291.748.6A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
156136671833.5133.166.5The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
156218331833.048.648.6New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
156318331833.054.454.4Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
156418331833.046.946.9Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
156536651832.592.646.3Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
156654971832.3121.440.5A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
156773281832.0139.134.8Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
156818311831.054.954.9Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
156918301830.042.842.8Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
157018301830.054.254.2Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
157118301830.034.234.2Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
157273171829.2208.452.1Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
157336571828.5106.253.1The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
157454851828.3153.551.2Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallieres, C M. MorinSleep Med200111438246Yes
157554811827.0140.446.8The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
157618271827.041.141.1PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
157736531826.5116.558.2Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
157818261826.040.740.7A revolution in optical manipulation. David G GrierNature200312917694No
157991301826.0218.743.7Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
158018231823.038.238.2Perceptions of epigenetics. Adrian BirdNature200717522671Yes
158136451822.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T CAMPBELL, D W FISKEPsychol Bull195913634291Yes
158218221822.062.162.1Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
158318211821.036.336.3Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
158418211821.089.089.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S COHENJ Biol Chem196213880319Yes
158536401820.090.245.1Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
158636321816.074.637.3Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
158718151815.037.737.7Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
158836291814.5105.752.9An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
158936291814.5138.469.2MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
159018141814.062.762.7A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
159190691813.896.119.2Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFEJAMA196314044222Yes
159236261813.0134.367.2The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
159318121812.059.159.1Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
159418111811.037.337.3Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
159536211810.5103.851.9Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
159618091809.042.942.9The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
159736171808.5101.550.8Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
1598180841808.4563.656.4Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
159936161808.0126.863.4Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
160036111805.580.240.1The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
160136101805.0149.874.9Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
160236091804.586.143.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
160318041804.038.938.9The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
160454111803.7174.058.0A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
160518031803.019.019.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
160690141802.8327.565.5Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. J B Saunders, O G Aasland, T F Babor, J R de la Fuente, M GrantAddiction19938329970Yes
160718011801.043.543.5Why genes in pieces? W GilbertNature1978622185Yes
160872001800.0277.769.416S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
160918001800.00.00.0The measurement of volume changes in human limbs. R J WHITNEYJ Physiol195313085295Yes
161017991799.097.797.7Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
161135961798.088.844.4The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
161217981798.035.735.7Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
161317961796.057.257.2Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
161417961796.055.555.5Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
161553791793.0319.5106.5Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
161635851792.5162.681.3Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
161717921792.046.946.9THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
161817911791.040.840.8Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
161917911791.038.438.4Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
162017911791.063.963.9A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
162117901790.054.454.4Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
162217901790.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HESTRINJ Biol Chem194918133390Yes
162317891789.037.637.6AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
162435781789.0166.383.2Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
162517881788.049.149.1Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
162617881788.063.863.8Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287Yes
162771501787.5307.276.8A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
162835751787.573.736.9Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
162917871787.058.558.5Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
163017871787.058.958.9Serum albumin. T PetersAdv Protein Chem19853904348No
163117871787.063.563.5Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
163217871787.094.594.5Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
163335711785.5152.476.2A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
163417851785.047.147.1Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
163517851785.037.637.6An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
163617851785.045.745.7Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
163717841784.042.642.6External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
163817821782.052.852.8Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
163935641782.086.243.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
164017821782.063.563.5Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
164117811781.053.753.7Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
164235611780.588.344.1Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
164371221780.5266.566.6QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
164417801780.035.935.9An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
1645195751779.5486.444.2The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
164617791779.065.965.9Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
164735581779.090.445.2Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
164817791779.047.047.0Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
164917781778.077.677.6The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
165035561778.088.544.2Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
165117781778.064.364.3Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
165235541777.068.534.2The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
165317771777.041.241.2Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
165417771777.050.650.6Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
165535531776.5109.354.6Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
165617761776.049.449.4Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
165717751775.039.139.1Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
165853241774.7123.241.1Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck OrntoftCancer Res200415289330Yes
165917731773.046.546.5Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
166017731773.021.221.2Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
166135401770.080.640.3Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
166217691769.060.660.6Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
166317691769.033.333.3Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
166417691769.073.573.5Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
166535371768.572.736.4Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
166617681768.058.458.4Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
166753041768.0118.939.6Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
166853031767.7114.238.1An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
166935351767.543.921.9A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
167088371767.4394.178.8Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L SalzbergNat Biotechnol201931375807Yes
167117671767.033.633.6The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
167252981766.0163.354.4Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
167317651765.064.164.1Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
167435301765.080.340.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
167517651765.038.138.1Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
167670571764.2244.561.1FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
167717641764.047.247.2G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
167817641764.074.874.8Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
167917641764.00.00.0A new readability yardstick. R FLESCHJ Appl Psychol194818867058Yes
168088201764.0307.861.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, J Clin Epidemiol200919631508No
168117631763.038.838.8ATPase activity of myosin correlated with speed of muscle shortening. M BaranyJ Gen Physiol19674227924Yes
168235231761.5149.874.9A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
168317611761.059.459.4The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
168417611761.040.140.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
168535211760.593.046.5Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
168635211760.580.040.0Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
168770401760.0212.453.1The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
168835181759.099.349.6Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
168917581758.040.040.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
169017581758.038.438.4The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SudhofNature19957791897No
169135161758.085.242.6Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
1692105461757.7211.935.3Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
169317571757.048.648.6The in vitro micronucleus technique. M FenechMutat Res200011113469No
169435131756.5225.3112.7The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
169517561756.044.444.4The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
169617561756.00.00.0A personality scale of manifest anxiety. J A TAYLORJ Abnorm Psychol195313052352Yes
169717561756.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
169817551755.033.533.5Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
169987751755.0354.570.9BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
170035091754.588.344.1Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
170117531753.053.953.9Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
170217531753.045.845.8Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
170335051752.5111.455.7The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
170417511751.059.459.4Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
170517501750.074.174.1Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
170617501750.060.360.3The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
170717501750.038.338.3In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
170817491749.036.236.2The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
170934971748.593.846.9Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
171069941748.5136.034.0Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
171117481748.059.959.9The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
171217481748.041.841.8Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
171352441748.0111.537.2Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
171417481748.038.738.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
171517471747.038.738.7Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
171617471747.040.140.1Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
1717209581746.5624.452.0A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, Ann Intern Med200919414839Yes
171817461746.040.940.9Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
171917461746.031.831.8Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
172017461746.017.517.5The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
172134911745.5114.057.0Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
172234901745.071.335.6The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
172317451745.066.166.1Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
172434881744.097.348.6Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
172517431743.039.239.2Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
172617421742.062.762.7Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
172734841742.086.243.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
172834821741.0221.4110.7A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
172934821741.068.934.5Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
173017411741.0153.2153.2COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
173134801740.091.946.0Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
173217391739.068.568.5A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
1733173821738.2548.854.9The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
173469531738.2217.054.2SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Soren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
173517381738.041.341.3Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
1736104271737.8286.547.8Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
173734751737.5128.464.2Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
1738156311736.8473.752.6The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
173934711735.571.735.9A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FluggeAnal Biochem19846731838Yes
174017351735.056.056.0Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
174117351735.069.269.2Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
174217351735.037.637.6Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
174334701735.096.548.2Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
174417351735.00.00.0The general adaptation syndrome and the diseases of adaptation. H SELYEJ Clin Endocrinol Metab194621025115Yes
174534681734.082.041.0CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
174634671733.589.844.9Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
174752001733.3273.391.1Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
174817331733.062.162.1Cyclosporine. B D KahanN Engl J Med19892687689No
174934641732.0128.164.03D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
175017311731.052.352.3A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
175134621731.075.137.5Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
175251901730.0111.437.1Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
175317301730.057.957.9Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
175451891729.7202.467.5The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
175517291729.031.431.4Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
175617291729.0122.0122.0The changing landscape of atherosclerosis. Peter LibbyNature202133883728No
175717281728.073.273.2The micronucleus test. W SchmidMutat Res197548190Yes
175817281728.056.056.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
175917271727.045.245.2A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
176051791726.3120.240.1Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
176117261726.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RANKINScott Med J195713432835Yes
176217241724.031.331.3How eukaryotic transcriptional activators work. M PtashneNature19883050531No
176317241724.035.835.8Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
176417231723.033.433.4DNA in a material world. Nadrian C SeemanNature200312540916No
176517231723.030.730.7Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
176617231723.077.977.9ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
176734451722.5131.665.8Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
176834441722.070.035.0The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
176951651721.7230.476.8Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
177017211721.044.344.3Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
177117191719.065.865.8Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
177217181718.047.147.1The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
177334351717.582.841.4Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
177417171717.044.244.2Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
177534341717.093.846.9Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
177617171717.096.296.2A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
177768661716.5143.836.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
177817161716.041.941.9The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
177917161716.048.148.1The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
178034321716.085.242.6The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
178117141714.051.851.8Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
178217141714.00.00.0Notes on continuous stochastic phenomena. P A P MORANBiometrika195015420245Yes
178334281714.0198.399.2An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
178417131713.072.772.7When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
178517131713.069.069.0Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
178617121712.073.673.6Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
178734231711.572.936.5Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
178817111711.051.451.4The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
178917111711.069.769.7PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
179034201710.065.532.8The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
179117101710.055.555.5Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
179234191709.582.441.2The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
179334181709.049.724.9A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J KARNOVSKY, L ROOTSJ Histochem Cytochem196414187330Yes
179434171708.577.838.9Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
179517081708.085.685.6Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. Cynthia RudinNat Mach Intell201935603010Yes
179634111705.571.135.5Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
179717051705.054.454.4A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
179834081704.0196.398.2Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
179917031703.042.842.8The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
180017031703.045.545.5Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
180117031703.049.949.9Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
180234041702.0103.351.6Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
180334041702.080.340.1Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
180417021702.089.989.9Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
180551051701.7130.143.4Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
180617011701.083.683.6Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerstromAddict Behav1978735910Yes
180717011701.037.837.8Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
180834011700.566.433.2Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
180917001700.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
181033981699.0112.856.4Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
181116991699.032.932.9Hox genes in vertebrate development. R KrumlaufCell19947913880No
181216991699.035.335.3Neuronal calcium signaling. M J BerridgeNeuron19989697848No
181316981698.055.355.3Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
181450941698.096.932.3T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
181516981698.047.347.3Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
181616971697.062.662.6MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
181784841696.8300.260.0Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
181816961696.031.231.2Switching and signaling at the telomere. E H BlackburnCell200111572773No
181933921696.069.935.0Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
182016951695.040.140.1A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
182116951695.037.637.6Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
182250851695.0155.952.0SCANPY: large-scale single-cell gene expression data analysis. F Alexander Wolf, Philipp Angerer, Fabian J TheisGenome Biol201829409532Yes
182333891694.575.137.5Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
182433881694.0110.655.3Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
182516941694.040.140.1The molecular genetics of cancer. J M BishopScience19873541204No
182633881694.093.046.5Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
182733861693.078.839.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
182816931693.038.338.3NADPH oxidase: an update. B M BabiorBlood199910029572No
182916931693.00.00.0Cerebral blood flow and oxygen consumption in man. N A LASSENPhysiol Rev195913645234Yes
183016931693.045.145.1Surface plasmon resonance sensors for detection of chemical and biological species. Jiri HomolaChem Rev200818229953No
183116921692.041.141.1Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
183216921692.037.437.4Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
183316911691.044.844.8Integrins. E RuoslahtiJ Clin Invest19911985087No
183416901690.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GRAYJ Anat195913829103Yes
183516901690.029.329.3Plastic Embedding Mixtures For Use In Electron Microscopy. H H MOLLENHAUERStain Technol196414127791Yes
183616901690.035.335.3Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
1837101381689.7231.238.5Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
183833791689.5133.266.6Interpreting findings from Mendelian randomization using the MR-Egger method. Stephen Burgess, Simon G ThompsonEur J Epidemiol201728527048Yes
183916881688.052.952.9Metallothionein. D H HamerAnnu Rev Biochem19863527054No
184016881688.043.043.0Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
184133751687.591.545.8Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
184216871687.058.758.7Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
184333741687.083.141.5EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
184416861686.022.622.6RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
184516861686.045.045.0Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
184633721686.070.535.2Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
184716851685.083.083.0Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
184816851685.031.831.8Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
184916831683.048.948.9Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
185016831683.029.929.9CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
185133661683.071.035.5The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
185216821682.043.243.2Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
185316821682.073.473.4Mood and memory. G H BowerAm Psychol19817224324Yes
185416821682.033.633.6Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
185516821682.063.563.5Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
1856100871681.2347.157.9Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
185716811681.038.138.1The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
185816811681.014.014.0Chromatographic Separation Of Human Brain Gangliosides. L SVENNERHOLMJ Neurochem196314066623Yes
185916811681.038.238.2The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
186016801680.043.143.1Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
186133571678.598.449.2Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
186233551677.564.232.1NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
186316771677.058.258.2Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
186450311677.0109.036.3Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
186516771677.043.443.4BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
186616761676.032.032.0Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
186716761676.041.541.5Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
186833461673.093.246.6Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
186916721672.032.332.3Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
187033421671.072.336.1The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
187116701670.049.249.2Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
187216701670.049.849.8Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
1873100181669.7226.437.7Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O LotvallNat Cell Biol200717486113Yes
187416691669.048.248.2The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
187516691669.040.340.3Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
187616691669.036.636.6Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
187750061668.7357.7119.2Ferroptosis: mechanisms, biology and role in disease. Xuejun Jiang, Brent R Stockwell, Marcus ConradNat Rev Mol Cell Biol202133495651No
187866741668.5209.352.3cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Ali Punjani, John L Rubinstein, David J Fleet, Marcus A BrubakerNat Methods201728165473Yes
187916681668.058.758.7Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
188016681668.00.00.0Method for the determination of hexosamines in tissues. N F BOASJ Biol Chem195313117829Yes
188116661666.052.052.0Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
188216661666.041.641.6Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
188333321666.054.327.1The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T OMURA, R SATOJ Biol Chem196414209972Yes
188416661666.034.934.9Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
188533311665.594.147.0The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
188649921664.0137.045.7Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
188716641664.039.239.2Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
188833261663.060.330.1Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
188916631663.033.733.7Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
189033251662.5119.359.6The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
189116611661.049.049.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
189216611661.047.047.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
189316611661.039.239.2Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
189466411660.2155.638.9Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
189566401660.0152.138.0Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
189616601660.063.363.3A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
189716601660.037.337.3A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
189816601660.037.437.4Upconversion and anti-Stokes processes with f and d ions in solids. Francois AuzelChem Rev200414719973Yes
189982991659.8284.156.8Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
190033181659.085.642.8Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
190116591659.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KETYPharmacol Rev195114833874Yes
190233181659.069.434.7Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
190333181659.0125.963.0A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
190416581658.056.856.8Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
190533151657.583.141.5Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
190616571657.044.744.7Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
190733131656.571.235.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
190816561656.031.331.3The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
190933101655.097.348.6Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
191033091654.5105.152.5How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
191116541654.062.462.4Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
191233081654.0115.557.8Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
191333071653.580.740.4Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
191416531653.036.236.2Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323Yes
191549571652.3124.541.5Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
191699081651.3317.052.8Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
191749541651.3104.034.7Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
191816511651.053.253.2Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
191949531651.0118.439.5Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
192016511651.064.764.7An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
192116501650.036.736.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
192216501650.022.522.5Structural considerations in the interaction of DNA and acridines. L S LERMANJ Mol Biol196113761054Yes
192316501650.039.139.1Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
192416501650.067.867.8The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
192516491649.050.150.1The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
192616491649.031.431.4Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
192732961648.093.746.9Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
192816481648.068.068.0The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
192916471647.048.348.3Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
193032931646.567.333.6Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassagueCell200617110329No
193149391646.3133.444.5Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
193216461646.033.233.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
193316461646.047.147.1Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
193416461646.045.045.0Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
193532921646.074.337.1Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
193616451645.034.834.8Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
193716451645.041.341.3Aspergillus fumigatus and aspergillosis. J P LatgeClin Microbiol Rev199910194462No
193832901645.059.129.6The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
193916451645.052.752.7PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
194049341644.7163.054.3CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
194132881644.096.748.4Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
194232881644.091.946.0What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
194316441644.039.339.3The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
194432881644.066.033.0Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
194516431643.046.946.9Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
194616421642.028.628.6Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
194716421642.027.527.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
194816421642.030.230.2Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
194916421642.059.559.5Inflammation, metaflammation and immunometabolic disorders. Gokhan S HotamisligilNature201728179656No
195032831641.565.532.8Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
195116411641.044.944.9Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
195216411641.056.556.5Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
195316401640.071.971.9The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
195416401640.049.949.9The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
195532791639.577.438.7Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
195616391639.043.843.8Bioactive microbial metabolites. Janos BerdyJ Antibiot (Tokyo)200515813176No
195732761638.071.135.5NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195816371637.075.975.9Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
195949111637.0124.441.5How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
196016371637.029.729.7Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
196132731636.592.646.3Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
196216361636.051.051.0Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
196316361636.070.970.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
196416361636.030.230.2Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
196516351635.034.334.3From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
196616351635.0101.8101.8A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MATTINGLYJ Clin Pathol196214471419Yes
196716351635.043.043.0n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
1968130731634.1307.538.4Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, N Engl J Med200211832527Yes
196916341634.051.351.3Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
197016341634.031.431.4The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
197116331633.028.628.6Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
197216331633.030.130.1Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
197332651632.574.537.2A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
1974114271632.4360.451.5The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, J Clin Epidemiol200818313558Yes
197516321632.030.230.2Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
197616321632.037.037.0The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
197716321632.037.737.7Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
197816321632.038.938.9Fast and robust fixed-point algorithms for independent component analysis. A HyvarinenIEEE Trans Neural Netw199918252563Yes
197932621631.0182.491.2Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J MARMUR, P DOTYJ Mol Biol196214470099Yes
198032611630.576.738.4Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
198116301630.050.850.8Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
198232571628.596.348.1Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E Barlow, Pediatrics200718055651Yes
198316281628.058.258.2Cell damage in the brain: a speculative synthesis. B K SiesjoJ Cereb Blood Flow Metab19816276420No
198416281628.042.442.4Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
198516271627.035.735.7Thiazolidinediones. Hannele Yki-JarvinenN Engl J Med200415356308No
198648781626.0175.758.6Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
198716261626.0111.8111.8Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
198816261626.029.929.9Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
198916251625.045.645.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
199016251625.071.571.5Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
199116251625.034.634.6Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
199232501625.067.133.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
199364961624.0276.069.0NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
199432461623.065.532.8Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
199581141622.8345.369.1CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
199632451622.578.239.1Obesity. David W Haslam, W Philip T JamesLancet200516198769No
199716221622.040.440.4Molecular biology of prion diseases. S B PrusinerScience19911675487No
199816221622.047.447.4Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
199916221622.046.146.1The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinasScience19883059497No
200048651621.7135.545.2The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
200148651621.793.131.0The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jurg TschoppMol Cell200212191486Yes
200248651621.753.817.9Improved method for the determination of blood glutathione. E BEUTLER, O DURON, B M KELLYJ Lab Clin Med196313967893Yes
200332431621.591.745.9Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
200416211621.0196.3196.3Epidemiology of chronic kidney disease: an update 2022. Csaba P KovesdyKidney Int Suppl (2011)202235529086No
200532411620.593.746.9An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
200632401620.0194.297.1A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
200732401620.062.331.1Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
200816201620.029.229.2Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
200932391619.581.240.6Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
201016191619.026.226.2Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
201116191619.060.060.01,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
201280931618.6291.558.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Int J Surg201020171303No
201316181618.052.452.4Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
201432361618.063.531.8Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
201532341617.078.939.5Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
201616161616.034.334.3On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
201732321616.060.230.1Mutations affecting segment number and polarity in Drosophila. C Nusslein-Volhard, E WieschausNature19806776413Yes
201816161616.033.633.6The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
201916151615.00.00.0Discharge patterns and functional organization of mammalian retina. S W KUFFLERJ Neurophysiol195313035466Yes
202016151615.051.051.0The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
202116151615.084.184.1Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
202296891614.8276.046.0TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
202348431614.3115.338.4Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
202416141614.029.329.3How cells read TGF-beta signals. J MassagueNat Rev Mol Cell Biol200011252892No
202516131613.051.551.5Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
202616131613.056.256.2Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
202732261613.077.338.6Dali server: conservation mapping in 3D. Liisa Holm, Paivi RosenstromNucleic Acids Res201020457744Yes
202832261613.077.738.9Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
202916121612.028.928.9Altering the genome by homologous recombination. M R CapecchiScience19892660260No
203016121612.050.750.7SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
203148351611.7117.739.2Management of hepatocellular carcinoma. Jordi Bruix, Morris Sherman, Hepatology200516250051No
203232231611.582.541.2Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
203316111611.032.732.7Drug discovery: a historical perspective. J DrewsScience200010720314No
203416101610.063.063.0Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
203516101610.031.431.4RNA silencing in plants. David BaulcombeNature200415372043No
203616091609.032.932.9Sustainable hydrogen production. John A TurnerScience200415310892Yes
203732171608.588.144.0Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
203832161608.0121.160.5The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
203932151607.5111.055.5Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
204016071607.036.536.5Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
204132141607.057.228.6Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
204264281607.0210.152.5The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
204364271606.8207.151.8Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior PachterNat Biotechnol201627043002Yes
204432121606.091.445.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
204548181606.088.529.5Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
204632111605.5113.156.5Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
204716051605.049.149.1Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
204832091604.567.133.5Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
204932091604.561.030.5Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
205032091604.578.039.0Abdominal obesity and metabolic syndrome. Jean-Pierre Despres, Isabelle LemieuxNature200617167477No
205116041604.029.329.3The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
205216041604.019.419.4Dithiothreitol, A New Protective Reagent For Sh Groups. W W CLELANDBiochemistry196414192894Yes
2053160341603.4374.737.5Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
205416031603.049.749.7The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
205516031603.034.134.1Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
205616021602.039.539.5Tumor necrosis factor (TNF). L J OldScience19852413547Yes
205732031601.563.031.5The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
205816011601.034.034.0Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
2059112041600.6263.937.7Integrative genomics viewer. James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
206048001600.093.831.3Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
206116001600.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OUCHTERLONYActa Pathol Microbiol Scand195313079779Yes
206215991599.036.536.5VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
206331981599.077.438.7A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
206415991599.044.544.5Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
206531981599.079.039.5A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
206631981599.0104.852.4A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
206779881597.6153.230.6Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
206831951597.576.638.3Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
206915971597.031.331.3An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
207015971597.035.235.2Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
207131931596.5102.051.0Mendelian randomization: genetic anchors for causal inference in epidemiological studies. George Davey Smith, Gibran HemaniHum Mol Genet201425064373No
207231921596.063.331.6Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
207315961596.046.346.3The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
207447831594.3115.038.3The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
207515931593.048.248.2Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
207615921592.042.542.5Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
207715921592.032.932.9DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
207815921592.051.751.7The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FrohlichInt J Nanomedicine201223144561No
207931831591.560.230.1Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
208015911591.039.439.4The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
208115911591.041.441.4Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
208247731591.0120.540.2I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
208315901590.042.842.8The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
208415901590.045.445.4The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
208531781589.072.236.1Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
208615891589.033.233.2Far-field optical nanoscopy. Stefan W HellScience200717525330No
208715891589.047.447.4Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
208815881588.081.081.0The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
208915881588.037.637.6HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
209031751587.596.248.1Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
209115871587.046.946.9Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
209215861586.050.250.2The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
209315861586.035.235.2The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
209415861586.00.00.0The generalisation of student's problems when several different population variances are involved. B L WELCHBiometrika194720287819Yes
209515861586.040.740.7Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
2096126861585.8308.938.6Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
209763371584.2245.261.3Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Jack Bowden, George Davey Smith, Philip C Haycock, Stephen BurgessGenet Epidemiol201627061298Yes
209831681584.0100.650.3The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
209915841584.041.541.5Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
210015841584.00.00.0Nutrition needs of mammalian cells in tissue culture. H EAGLEScience195513255879Yes
210131681584.061.530.8Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
210215831583.031.431.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
210331661583.0100.650.3Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
210415831583.053.653.6Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
210547481582.7156.752.2Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
210647421580.7150.750.2Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graca Raposo, Clotilde TheryAnnu Rev Cell Dev Biol201425288114No
2107205471580.5514.639.6Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
210863211580.2154.538.6Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
210915801580.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HUMMELCan J Biochem Physiol195914405350Yes
211015801580.044.344.3Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
211115791579.052.552.5Biology of interleukin 1. C A DinarelloFASEB J19883277884No
211215791579.039.339.3Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
211331571578.566.033.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
211415781578.079.179.1Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
211515771577.064.864.8Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
211615771577.044.944.9Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
211763041576.0259.264.8Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
211863031575.8149.137.3Universal sample preparation method for proteome analysis. Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
211931501575.0185.993.0Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Helmut Sies, Dean P JonesNat Rev Mol Cell Biol202032231263No
212031491574.5340.9170.4Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Luke A McGuinness, Julian P T HigginsRes Synth Methods202132336025Yes
212115721572.058.958.9Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
212215721572.053.753.7The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
212315721572.042.542.5Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
212447151571.791.630.5Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
212515711571.038.538.5Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
212615711571.057.857.8What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhaSoc Sci Med200919520474Yes
212715711571.044.644.6Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
212831401570.079.839.9Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
212962791569.8118.929.7A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
213015691569.037.037.0Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
213131361568.095.647.8Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
213247031567.7141.147.0Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
213347011567.0262.387.4MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
213431311565.521.610.8Junctional complexes in various epithelia. M G FARQUHAR, G E PALADEJ Cell Biol196313944428Yes
213531301565.097.548.8The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
213631291564.588.644.3Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
213746921564.0128.342.8Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
213831281564.068.034.0Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
213915631563.043.643.6The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
214015631563.055.055.0Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
214162481562.0179.144.8Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
214231241562.038.619.3Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
214315611561.056.756.7Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
214415611561.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
214515611561.058.258.2Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
214615601560.042.542.5Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
214715591559.028.028.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
214815591559.041.341.3The pollution of the marine environment by plastic debris: a review. Jose G B DerraikMar Pollut Bull200212405208No
214915591559.031.331.3Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
215077911558.2267.853.6Salmon provides fast and bias-aware quantification of transcript expression. Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl KingsfordNat Methods201728263959Yes
215115581558.033.133.1The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
215231151557.5149.174.5Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
215315571557.036.336.3Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
215415561556.053.253.2Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
215515561556.059.759.7Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
215615561556.031.931.9Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
215731111555.560.430.2Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
215831101555.096.548.2Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
215915541554.040.540.5Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
216015541554.033.833.8Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
216146611553.7102.834.3Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
216231071553.599.449.7Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
216315531553.043.843.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
216415531553.048.848.8Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
216515531553.064.964.9Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
216646581552.7110.336.8Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
216715521552.032.632.6Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
216815511551.075.975.9Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
216931001550.0173.186.5Osteoarthritis. David J Hunter, Sita Bierma-ZeinstraLancet201931034380No
2170108451549.3227.232.5Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
217115491549.055.055.0Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
217215491549.018.318.3A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
217315491549.045.145.1The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
217415491549.068.568.5Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
217515491549.039.639.6Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
217615481548.092.192.1Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
217715481548.043.043.0Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
217815481548.046.046.0The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
217930951547.589.144.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
218061871546.8143.936.0CHARMM-GUI: a web-based graphical user interface for CHARMM. Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil ImJ Comput Chem200818351591No
218115461546.046.146.1Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
218215451545.046.246.2Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
218346331544.389.129.7A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
218415441544.032.532.5Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
218546311543.7159.353.1Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
218615431543.012.512.5The Relation Of Recombination To Mutational Advance. H J MULLERMutat Res196414195748Yes
218730851542.570.835.4New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
218815421542.029.429.4A New Weighting System For Mean Surface Temperature Of The Human Body. N L RAMANATHANJ Appl Physiol196414173555Yes
2189107931541.9348.949.8Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
219046251541.7155.351.8Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
219115411541.098.298.2The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
219230821541.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbruckGenetics194317247100Yes
219330811540.566.833.4How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
219446211540.396.732.2The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
219515401540.052.252.2Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
219615391539.029.929.9E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
219715391539.045.845.8Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
219815391539.033.433.4The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
219961531538.2272.868.2Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron DoNat Genet201829686387Yes
220015381538.037.537.5An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
220115371537.057.857.8Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
220215371537.033.933.9Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
220330741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G SCHMIDT, S J THANNHAUSERJ Biol Chem194521005717Yes
220415361536.045.745.7Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
220515361536.050.150.1Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
220615361536.035.435.4Proinflammatory cytokines. C A DinarelloChest200010936147No
220746061535.3109.336.4Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
220815341534.056.956.9Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
220915331533.033.533.5Molecular themes in oncogenesis. J M BishopCell19911988146No
221015331533.040.840.8Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
221115331533.050.450.4Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
221245991533.093.531.2TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
221315311531.021.321.3An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
221430611530.560.030.0Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
221545911530.3125.141.7The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
221615301530.050.250.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
221715301530.044.744.7Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
221815301530.043.643.6Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
221945861528.7104.734.9Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
222015281528.030.730.7Antigen-Antibody Crossed Electrophoresis. C B LAURELLAnal Biochem196514302464Yes
222130551527.5115.257.6Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958Yes
222215271527.038.138.1Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
222315271527.035.235.2Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
222461051526.2130.432.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
222530521526.090.145.0Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
222615261526.026.526.5Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
222715261526.040.940.9Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
222815261526.033.733.7Huntington's disease. Francis O WalkerLancet200717240289No
222945771525.7165.855.3Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
223045771525.7101.633.9Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
223130511525.587.343.6A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
223245761525.3141.447.1AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. G Paxinos, C R Watson, P C EmsonJ Neurosci Methods19806110810Yes
223315251525.044.844.8Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
223415251525.038.638.6Early signals in the mitogenic response. E RozengurtScience19863018928No
223515251525.048.048.0Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
223630491524.5103.551.8The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
223730491524.558.629.3Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
223815241524.037.437.4Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
223915241524.048.748.7AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
224015241524.039.639.6Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
224115231523.059.159.1The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
224215221522.027.027.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
224315221522.057.457.4Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
224415211521.044.844.8Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
224515211521.025.225.2Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FUXEActa Physiol Scand Suppl196514319769Yes
224630411520.584.942.5CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
224715201520.019.219.2Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
224815201520.042.742.7Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
224915191519.042.142.1Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
225045541518.097.532.5Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
225115181518.037.837.8Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
225230331516.577.939.0Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
225330331516.5236.1118.0Gut microbiota in human metabolic health and disease. Yong Fan, Oluf PedersenNat Rev Microbiol202132887946No
225415161516.039.739.7Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
225515161516.031.931.9Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
225615161516.036.236.2The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
225730311515.561.930.9The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
225815151515.042.642.6Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
225945441514.7261.287.1Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A WINTER, E A RISLEY, G W NUSSProc Soc Exp Biol Med196214001233Yes
226030281514.058.529.2Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
226115141514.022.122.1Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
226215141514.038.438.4The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
226330281514.0108.254.1Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
226430271513.592.946.5Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
226515131513.034.134.1Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
226630251512.599.049.5Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
226715121512.046.846.8Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
226890701511.7266.844.5The Molecular Signatures Database (MSigDB) hallmark gene set collection. Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo TamayoCell Syst201526771021Yes
226930221511.0100.450.2Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
227015111511.038.238.2Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
227130221511.071.035.5Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
227215101510.049.349.3Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
227315091509.040.540.5Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
227415091509.050.150.1Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
227515091509.033.733.7Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
227630161508.00.00.0Lactic dehydrogenase activity in blood. F WROBLEWSKI, J S LADUEProc Soc Exp Biol Med195513273400Yes
227730151507.568.134.0Emerging roles of caspase-3 in apoptosis. A G Porter, R U JanickeCell Death Differ199910200555No
227830151507.556.428.2Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
227915071507.034.534.5Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
228015071507.028.828.8The significance of responses of the genome to challenge. B McClintockScience198415739260No
228130111505.594.847.4Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BackhedNature201222972297No
228230101505.056.728.4Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
228315051505.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MOUNTCASTLEJ Neurophysiol195713439410Yes
228415051505.043.843.8The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
228515051505.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
228615051505.061.261.2Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
228730091504.597.848.9Nitric oxide synthases: regulation and function. Ulrich Forstermann, William C SessaEur Heart J201221890489No
228830091504.575.737.9Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
228945131504.3148.149.4Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
229015041504.044.944.9Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
229115041504.063.163.1The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
229215031503.052.052.0Lyme disease. A C SteereN Engl J Med19892668764No
229315031503.017.817.8The mechanism of muscular contraction. H E HuxleyScience19694181952No
229415031503.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
229515031503.038.638.6Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
229615021502.032.732.7Tumor suppressor genes. R A WeinbergScience19911659741No
229715021502.038.338.3The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
229815011501.036.936.9Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
229915011501.040.040.0The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
230030011500.598.049.0Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
230115001500.043.243.2Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
230215001500.08.08.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SPERRYProc Natl Acad Sci U S A196314077501Yes
230315001500.042.542.5Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
230429991499.569.734.9Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
230514991499.030.530.5The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
230659941498.5300.175.0Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E HoltPLoS Comput Biol201728594827Yes
230714971497.038.438.4Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
230814971497.050.350.3Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
230914971497.025.525.5The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
231029941497.082.741.4A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marcais, Carl KingsfordBioinformatics201121217122Yes
231114961496.053.453.4The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
231214951495.036.836.8Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
231314951495.051.551.5Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
231414941494.036.136.1Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
231514931493.072.272.2Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
231629851492.567.633.8Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
231714921492.033.833.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
231814921492.039.039.0The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
231914921492.040.940.9Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DomlingChem Rev200616402771No
232029811490.589.144.5DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
232144711490.345.915.3The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T DODGE, C MITCHELL, D J HANAHANArch Biochem Biophys196314028302Yes
232229801490.075.337.6Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
232314891489.039.239.2Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
232414891489.052.352.3Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
232514871487.040.440.4Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
232614871487.030.630.6Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
232714861486.034.834.8Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
232814861486.026.326.3Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
232914861486.033.233.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
233014861486.00.00.0An approximate distribution of estimates of variance components. F E SATTERTHWAITEBiometrics194620287815Yes
233159421485.5248.562.1A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
2332133651485.0409.545.5The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
233314851485.034.134.1The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
233414841484.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
233514841484.043.443.4The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
233629671483.576.838.4Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
233774161483.2171.134.2Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J BartonBioinformatics200919151095Yes
233814831483.043.043.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
233914831483.031.631.6Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
234029661483.099.649.8Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
234144481482.795.932.0OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
234214821482.038.838.8Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
234329631481.578.039.0Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
234429631481.581.740.9Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
234514811481.035.235.2The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
234614811481.054.754.7Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
234729601480.091.946.0The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
234814801480.053.453.4The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
234914801480.010.610.6Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HUXLEYJ Mol Biol196314064165Yes
235073981479.6266.853.4Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
235114791479.095.195.1The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
235229581479.096.148.0The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
235314791479.033.633.6PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
235429581479.067.833.9Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
235529571478.576.038.0The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
235629561478.0153.376.7Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
235714781478.030.830.8Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
235814781478.034.334.3Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NOWELLCancer Res196014427849Yes
235929541477.068.034.0The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
236029531476.563.531.8Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
236114761476.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H ROSENArch Biochem Biophys195713412116Yes
236244251475.0185.661.9Hepatocellular carcinoma. Alejandro Forner, Maria Reig, Jordi BruixLancet201829307467No
236329481474.0157.778.8The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G GRAY, V P WHITTAKERJ Anat196213901297Yes
236414741474.098.898.8A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
236529471473.597.648.8Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
236629471473.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
236714731473.043.643.6Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
236814731473.030.330.3Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
236929451472.578.039.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
237029451472.582.041.0The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
237114711471.061.461.4Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
237214701470.038.038.0Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
237329401470.054.227.1T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
237414701470.036.536.5Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
237514701470.038.238.2A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
237614701470.036.536.5The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
237729401470.0102.751.4Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
237814691469.047.747.7A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
237929381469.055.127.6Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
238014691469.031.531.5Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
238188101468.3313.552.2Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
238214681468.025.825.8The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
238314671467.044.844.8Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
238443971465.7131.443.8Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
238543961465.393.031.0Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
238643951465.094.631.5Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornoe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
238714651465.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
238814641464.032.732.7Simple methods for "staining with lead" at high pH in electron microscopy. M J KARNOVSKYJ Biophys Biochem Cytol196114454024Yes
238929281464.066.833.4Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
239029271463.554.727.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
239114631463.039.639.6A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
239214631463.057.757.7Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
239314631463.041.841.8Function and information content of DNA methylation. Dirk SchubelerNature201525592537No
2394102381462.6405.257.9Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
239543871462.392.430.8NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
239614621462.034.334.3Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
239729241462.057.528.8Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
239814621462.029.029.0Human natural killer cells. Michael A CaligiuriBlood200818650461No
239929241462.092.046.0MissForest--non-parametric missing value imputation for mixed-type data. Daniel J Stekhoven, Peter BuhlmannBioinformatics201222039212Yes
240029241462.0113.656.8Using Effect Size-or Why the P Value Is Not Enough. Gail M Sullivan, Richard FeinnJ Grad Med Educ201223997866Yes
240143841461.3150.550.2Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
240214611461.020.820.8Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
240329221461.085.943.0The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
240443831461.086.428.8The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
240514611461.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BUSHBiochem J195214915960Yes
240614611461.056.956.9Diagnostic and Statistical Manual of Mental Disorders (DSM). Dolores Elaine BattleCodas201324413388Yes
240714611461.045.945.9ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Tristan Ian CrollActa Crystallogr D Struct Biol201829872003Yes
240873031460.6273.554.7DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
240929211460.562.631.3The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
241029201460.085.442.7Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
241129181459.099.849.9Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
241229181459.076.038.0Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
241343761458.7109.036.3LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
241472911458.2204.740.9Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
241514581458.047.047.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
241614581458.034.734.7TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
241714581458.032.832.8Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
241843731457.789.329.8Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
241929151457.5105.752.9Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
242058291457.2206.051.5Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
242114571457.033.533.5Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
242214571457.085.185.1A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
242329141457.071.435.7The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
242429141457.062.931.4Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
242514571457.054.854.8The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
242614571457.081.781.7Head and Neck Cancer. Laura Q M ChowN Engl J Med202031893516No
242729131456.568.234.1The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
242829121456.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H CLARKE, J CASALSAm J Trop Med Hyg195813571577Yes
242943661455.3134.244.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
243014551455.029.129.1The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
243114551455.040.240.2Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
243214551455.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F ROSENBLATTPsychol Rev195813602029Yes
243314551455.042.242.2Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
243429091454.572.136.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
243514541454.035.635.6General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
243614541454.047.147.1Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
243758151453.8240.060.0Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
243829071453.5116.658.3Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
243929071453.584.842.4Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
244029071453.580.940.5Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluisio J D Barros, Vania N HirakataBMC Med Res Methodol200314567763Yes
244187211453.5297.349.6StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L SalzbergNat Biotechnol201525690850Yes
244214531453.041.441.4The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
244329061453.079.940.0Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
244414531453.031.331.3The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
244529061453.052.726.4Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
244614531453.027.627.6Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
244729041452.079.539.8A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
244814521452.039.739.7Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
244943561452.0156.952.3Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
245029021451.037.018.5Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A DAHLSTROEM, K FUXEActa Physiol Scand Suppl196414229500Yes
245129011450.50.00.0Virus interference. I. The interferon. A ISAACS, J LINDENMANNProc R Soc Lond B Biol Sci195713465720Yes
245214501450.034.934.9Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
245343501450.0115.038.3TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
245429001450.0118.859.4AMPK: guardian of metabolism and mitochondrial homeostasis. Sebastien Herzig, Reuben J ShawNat Rev Mol Cell Biol201828974774No
245528991449.578.239.1Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
245628991449.566.233.1Inflammation, stress, and diabetes. Kathryn E Wellen, Gokhan S HotamisligilJ Clin Invest200515864338No
245714491449.048.348.3Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
245814491449.040.940.9Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
245928961448.065.532.8Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
246014481448.031.031.0Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
2461231681448.0617.938.6New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
246228951447.570.435.2Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
246357881447.0153.638.4The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
246486791446.5213.335.6A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
246572321446.4155.031.0Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
246643391446.3203.567.8Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
246728901445.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J BLOOM, W W RICHARDSONBr J Cancer195713499785Yes
246828891444.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D DAVIS, E S MINGIOLIJ Bacteriol195015436457Yes
246928891444.571.235.6An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
247028891444.589.444.7CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. Jing Huang, Alexander D MacKerellJ Comput Chem201323832629Yes
247114441444.043.143.1Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
247243291443.086.528.8Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
247314431443.036.736.7T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
247428851442.5104.152.0The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
247514421442.026.626.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
247614421442.033.333.3Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
247728841442.059.429.7LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
247814421442.070.170.1SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
247943241441.3111.837.3Nitric oxide and peroxynitrite in health and disease. Pal Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
248014411441.037.037.0Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
248114411441.055.355.3The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
248228811440.599.749.9Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Christoph Hafemeister, Rahul SatijaGenome Biol201931870423Yes
248314401440.017.017.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
248428801440.071.335.6Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
248514401440.067.567.5The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
248628801440.070.435.2Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
248714401440.045.145.1How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
248814401440.035.535.5The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
248914401440.055.355.3How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
249028791439.570.135.0Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
249128791439.5174.287.1A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H ANTON, D F SAYREJ Pharmacol Exp Ther196214013351Yes
249214391439.00.00.0The critical incident technique. J C FLANAGANPsychol Bull195413177800Yes
249343171439.0108.436.1Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
249414391439.030.530.5Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
249514391439.085.285.2Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
249628751437.577.438.7Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
249714371437.054.254.2Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
249814371437.034.334.3Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
249914371437.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D POULIKNature195713493570Yes
250071821436.4359.771.9Standards for reporting qualitative research: a synthesis of recommendations. Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A CookAcad Med201424979285Yes
250114361436.031.231.2The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
250243081436.099.533.2Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
250314361436.033.033.0The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
250414351435.040.340.3Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
250514341434.038.438.4Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
250628681434.066.233.1C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
250714341434.029.629.6A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
250843011433.792.830.9Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
250914331433.058.558.5Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
251014331433.016.616.6Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WYMANAdv Protein Chem196414268785No
251114331433.032.832.8What is a support vector machine? William S NobleNat Biotechnol200617160063No
251214321432.046.146.1Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
251314321432.035.135.1Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
251414321432.031.831.8Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
251528631431.584.842.4bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
251614311431.050.350.3Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
251714311431.029.329.3Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
251814311431.012.812.8The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
251942921430.7139.746.6Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
252028601430.083.041.5Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
252114301430.033.033.0Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
252214301430.046.446.4Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
252385761429.3206.934.5An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
252414291429.038.938.9Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
252528581429.066.433.2Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
252614291429.050.550.5The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
252714291429.066.866.8Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Hae-Young KimRestor Dent Endod201323495371Yes
252814281428.036.436.4Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
252914271427.029.029.0Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
253014271427.026.926.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
253114271427.049.249.2The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
253228531426.577.438.7Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
253328531426.558.129.1The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
253414261426.028.028.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
253514251425.043.143.1Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
253628501425.066.733.4Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
253728501425.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L HODGKIN, B KATZJ Physiol194918128147Yes
253814251425.044.144.1The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
253928491424.581.140.5Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
254028481424.088.744.4Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
254114241424.027.927.9Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
254228471423.595.747.9A new scale of social desirability independent of psychopathology. D P CROWNE, D MARLOWEJ Consult Psychol196013813058Yes
254314231423.024.424.4The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
254414231423.040.340.3Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
254514231423.052.852.8How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
254614221422.036.936.9Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
254714221422.041.741.7The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
254828431421.567.733.9Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
254956851421.2191.848.0Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
255014211421.048.748.7Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
255128421421.069.434.7Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
255242631421.0131.143.7Mendelian randomization analysis with multiple genetic variants using summarized data. Stephen Burgess, Adam Butterworth, Simon G ThompsonGenet Epidemiol201324114802Yes
255356801420.0148.737.2AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
255442591419.7264.588.2Correlation Coefficients: Appropriate Use and Interpretation. Patrick Schober, Christa Boer, Lothar A SchwarteAnesth Analg201829481436No
255514191419.031.331.3Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
255614191419.039.439.4Endometriosis. Serdar E BulunN Engl J Med200919144942No
255728381419.082.941.5The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
255842561418.7117.139.0A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
255914181418.036.036.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
256014181418.033.233.2The basic science of gene therapy. R C MulliganScience19938493530No
256114181418.029.029.0Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
256228351417.554.627.3Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
256370861417.2249.749.9The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
256414171417.050.650.6Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
256514171417.025.225.2Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
256685021417.0219.936.6Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
256728341417.097.848.9Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
256814161416.035.435.4The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
256928311415.5106.053.0Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
257028311415.5114.357.1Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
257114151415.029.129.1Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
2572141441414.4520.152.0MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
257314141414.029.029.0HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
257414141414.031.131.1Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
257528281414.068.134.0The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
257614131413.031.931.9Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
257714131413.025.225.2c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
257828261413.069.034.5Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
257928251412.5106.753.4Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
258028251412.582.541.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
258128251412.5171.685.8Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
258214121412.041.341.3Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
258328241412.073.636.8New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
258428231411.598.649.3Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
258528231411.571.135.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
258628221411.064.032.0Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
258714111411.032.132.1A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
258828201410.042.321.1Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
258914101410.043.443.4The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
259014101410.025.925.9NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
259156391409.8142.735.7The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan Shaw, Lancet200516182882Yes
259228181409.081.640.8Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
259314091409.032.632.6Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
259414091409.047.747.7Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
259542231407.779.926.6Exosomes: composition, biogenesis and function. Clotilde Thery, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
259614071407.032.532.5Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
259728141407.094.847.4Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
259814071407.030.830.8Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
259914071407.035.235.2The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
260056241406.0140.735.2Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
260114061406.025.125.1ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
260214061406.049.449.4The non-canonical NF-κB pathway in immunity and inflammation. Shao-Cong SunNat Rev Immunol201728580957No
260370291405.8130.426.1Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mader, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260428111405.562.531.2Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
260528101405.0128.464.2Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
260614051405.034.234.2Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
260728081404.0142.471.2Depression. Gin S Malhi, J John MannLancet201830396512No
260842111403.783.827.9Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
260928071403.561.830.9Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
261042101403.395.831.9Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
261114031403.043.143.1Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
261242071402.393.731.2Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
261314021402.040.740.7Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
261414021402.021.221.2A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
261528031401.571.835.9miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
261698081401.1285.140.7Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
261714011401.039.039.0A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
261828021401.061.730.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
261927991399.586.343.1A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
262013991399.015.215.2Central dogma of molecular biology. F CrickNature19704913914No
262141961398.7105.835.3Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
262227971398.571.035.5Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
262313981398.022.222.2Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
262413981398.034.434.4Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
262513981398.038.238.2The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
262613981398.066.266.2The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
262713971397.027.927.9Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SudhofNature200818923512No
262827931396.561.830.9The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
262927931396.560.630.3An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
263027911395.581.640.8Microdetermination of long-chain fatty acids in plasma and tissues. V P DOLE, H MEINERTZJ Biol Chem196013817286Yes
263127901395.0101.150.5Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
263213951395.030.730.7Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
263313951395.040.840.8Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
263427901395.061.430.7Immunoassay of endogenous plasma insulin in man. R S YALOW, S A BERSONJ Clin Invest196013846364Yes
263527891394.559.729.9NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
263613941394.044.344.3Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
263713941394.029.629.6Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
263827871393.5120.360.1New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Anushka Dongre, Robert A WeinbergNat Rev Mol Cell Biol201930459476No
263913931393.026.226.2microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
264013931393.035.235.2Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
264113931393.032.232.2Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
2642167081392.3416.234.7Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, J Gerontol A Biol Sci Med Sci200111253156Yes
264369611392.2184.837.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
264413921392.060.360.3Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
264513921392.025.525.5Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
264641741391.390.830.3Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
264713911391.024.124.1Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
264813911391.028.328.3Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
264913911391.036.736.7Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
265013911391.043.043.0Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
265113901390.031.231.2The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
265227801390.083.241.6Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
265313901390.027.527.5The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
265455601390.0262.465.6The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
265555571389.2118.729.7Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
265613891389.072.772.7Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
265713891389.029.529.5Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
265813891389.029.129.1Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
265913891389.064.164.1Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
2660166591388.21148.595.7The REDCap consortium: Building an international community of software platform partners. Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, J Biomed Inform201931078660Yes
266141641388.0119.139.7Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
266213881388.032.432.4Hydrogen sulphide and its therapeutic potential. Csaba SzaboNat Rev Drug Discov200717948022No
266313871387.010.910.9Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
266427731386.555.327.6Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
266513861386.034.834.8Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
266613861386.031.131.1Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
266727711385.571.235.6A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
266827711385.50.00.0Construct validity in psychological tests. L J CRONBACH, P E MEEHLPsychol Bull195513245896Yes
266927711385.551.225.6STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
267013851385.023.923.9Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
267127701385.077.038.5Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
267227701385.0101.250.6Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
267327701385.084.542.2Liquid phase condensation in cell physiology and disease. Yongdae Shin, Clifford P BrangwynneScience201728935776No
267413841384.043.243.2Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
267527681384.054.827.4Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
267613841384.028.428.4Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
267713841384.036.136.1Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
267827671383.554.527.2Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
267913831383.040.440.4Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
268013821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SCHNEIDERJ Biol Chem194818886166Yes
268127631381.570.335.1A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
268227621381.096.348.1A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
268327621381.0164.582.2A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
268413811381.023.623.6SUMO: a history of modification. Ronald T HayMol Cell200515808504No
268582861381.0203.733.9Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat RoblesBioinformatics200516081474Yes
268655211380.2190.947.7MultiQC: summarize analysis results for multiple tools and samples in a single report. Philip Ewels, Mans Magnusson, Sverker Lundin, Max KallerBioinformatics201627312411Yes
268713801380.039.239.2Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
268813801380.036.636.6Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
268941341378.0146.848.9A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
269027551377.570.235.1Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WuthrichBiochem Biophys Res Commun19836307308Yes
269113771377.011.411.4Immunological function of the thymus. J F MILLERLancet196114474038Yes
269213771377.035.335.3Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
269313761376.032.332.3Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
269413761376.049.349.3Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
269513751375.041.941.9Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
269627491374.567.233.6Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
269754971374.2125.431.4The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
269813741374.00.00.0On the psychophysical law. S S STEVENSPsychol Rev195713441853Yes
269913741374.031.931.9Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
270013741374.027.327.3Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
270113741374.049.749.7A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
270213731373.043.643.6History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
270313731373.039.039.0Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
270413731373.030.430.4Optical microcavities. Kerry J VahalaNature200312917698Yes
270513731373.00.00.0The relation of the trail making test to organic brain damage. R M REITANJ Consult Psychol195513263471Yes
270613731373.022.822.8Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
270727461373.076.938.5Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
270827451372.573.036.5Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
270927451372.598.449.2AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
271027441372.054.327.1Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
271127431371.50.00.0The respiratory chain and oxidative phosphorylation. B CHANCE, G R WILLIAMSAdv Enzymol Relat Subj Biochem195613313307Yes
271213711371.047.047.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
271341101370.0120.040.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
271413701370.031.031.0Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
271513701370.033.133.1Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
271627391369.556.128.1Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
271741081369.399.633.2Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C Kearon, J Thromb Haemost200515842354Yes
271813691369.032.632.6Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
271927381369.053.726.9A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
272013691369.046.246.2Interleukin-1. C A DinarelloRev Infect Dis19846369481No
272113681368.027.327.3Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
272213681368.035.935.9Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
272382081368.0226.937.8Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
272427361368.090.445.2Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
272554691367.2105.526.4Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
272641011367.084.328.1Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
272713671367.035.335.3Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
272813671367.035.235.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
272913671367.083.683.6COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
273068341366.8210.242.0CD-HIT: accelerated for clustering the next-generation sequencing data. Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong LiBioinformatics201223060610Yes
273113661366.027.027.0Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
273213661366.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SMITHIESBiochem J195913638269Yes
273327321366.075.537.8Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
273413661366.045.145.1Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
273513651365.045.145.1Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
273613651365.033.733.7A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
273713651365.00.00.0The anterior approach for removal of ruptured cervical disks. R B CLOWARDJ Neurosurg195813599052Yes
273813651365.065.765.7Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Nicholas A MeanwellJ Med Chem201829400967No
273927291364.566.333.1Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
274013641364.046.746.7Multiple calcium channels and neuronal function. R J MillerScience19872432656No
274181831363.8285.747.6Second-generation PLINK: rising to the challenge of larger and richer datasets. Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J LeeGigascience201525722852Yes
274227271363.569.434.7Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
274313631363.023.223.2Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
274413631363.029.629.6The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
274513631363.035.935.9How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
274627261363.056.628.3Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
274713611361.038.038.0Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
274813611361.042.342.3The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
274913611361.044.444.4The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
275027201360.039.619.8Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
275113601360.041.241.2Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
275213601360.029.829.8Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
275313601360.00.00.0Comparing individual means in the analysis of variance. J W TUKEYBiometrics194918151955Yes
275454391359.8116.129.0A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
275527191359.579.539.8Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
275613591359.041.641.6Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
275713591359.046.946.9Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
275813591359.028.528.5Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
275927171358.572.236.1A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
276040751358.390.830.3Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
276113581358.028.528.5The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
276213581358.058.058.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
276327161358.046.923.4Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
276413581358.023.123.1The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
276513581358.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CAULFIELDJ Biophys Biochem Cytol195713475399Yes
276654301357.5124.231.1Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
276727151357.5103.952.0Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
276813571357.043.143.1An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
276913571357.035.635.6Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
277027131356.578.139.0Opportunities and challenges for a sustainable energy future. Steven Chu, Arun MajumdarNature201222895334No
277154251356.2170.942.7Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
277213561356.048.248.2The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
277313561356.063.463.4Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
277427121356.069.034.5Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
277513561356.043.143.1Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
277613561356.045.445.4Electrolytes and interphases in Li-ion batteries and beyond. Kang XuChem Rev201425351820Yes
277727111355.561.830.9NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
277854201355.0146.636.6GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
277940641354.7124.941.6MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
278027091354.561.130.6The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
278113541354.025.725.7Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
278227081354.052.426.2Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
278313541354.039.639.6Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
278440601353.349.516.5Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D SABATINI, K BENSCH, R J BARRNETTJ Cell Biol196313975866Yes
278513531353.035.335.3Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
278613531353.024.324.3Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
278713531353.032.732.7N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
2788135291352.9465.546.5The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
278940581352.7127.642.5Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
279027051352.5120.560.2Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
279181131352.2236.739.4Prodigal: prokaryotic gene recognition and translation initiation site identification. Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J HauserBMC Bioinformatics201020211023Yes
279213521352.034.134.1Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
279327041352.058.929.4A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
279413521352.057.857.8Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
279527031351.564.132.0Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
279613511351.033.533.5Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
279754041351.0119.329.8Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
279840521350.798.232.7Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
279954021350.5160.240.0Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
280027001350.0134.367.2A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
280127001350.068.334.1Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
280226991349.560.930.4Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
280353971349.2300.475.1Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
280413491349.023.223.2Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
280540471349.093.431.1Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
280640461348.799.433.1Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
280726971348.555.727.9Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
280826951347.5220.7110.3Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
280926951347.572.036.0The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
281026941347.057.428.7Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
281113471347.044.044.0Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
281213471347.066.166.1Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
281313471347.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WADDELLJ Lab Clin Med195613346201Yes
281413461346.016.916.9Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
281513461346.036.036.0Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
281613451345.035.535.5Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
281713451345.035.835.8The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
281813451345.063.063.0Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
281926891344.586.643.3Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
282013441344.034.734.7Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
282126851342.587.443.7Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
282213421342.046.846.8Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
282326821341.044.722.4Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
2824107251340.6259.432.4A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
282526811340.572.836.4What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
282640211340.3194.965.0Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
282713401340.063.163.1Cellular resistance to infection. G B MACKANESSJ Exp Med196214467923Yes
282813401340.059.659.6The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
282926791339.574.937.5Inflammatory mechanisms in obesity. Margaret F Gregor, Gokhan S HotamisligilAnnu Rev Immunol201121219177No
283053581339.5231.557.9Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GokerBMC Bioinformatics201323432962Yes
283140181339.383.827.9A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
283213391339.034.934.9The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
283313391339.051.751.7Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
283413391339.055.355.3Error in medicine. L L LeapeJAMA19947503827Yes
283526781339.065.432.7Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
283613391339.027.227.2Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
2837120451338.3290.232.2MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
283853531338.2146.436.6Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
283913381338.045.145.1The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
284013381338.024.624.6A modified procedure for lead staining of thin sections. G MILLONIGJ Biophys Biochem Cytol196114474176Yes
284126761338.084.642.3A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschopeJ Am Coll Cardiol201323684677No
284213381338.043.943.9Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamas RoszerMediators Inflamm201526089604No
284326741337.062.031.0Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
284413371337.032.032.0Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
284513371337.030.230.2Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
284613371337.052.652.6The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615Yes
284726731336.5148.174.0Sarcopenia. Alfonso J Cruz-Jentoft, Avan A SayerLancet201931171417No
284813361336.024.624.6Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
284913361336.032.432.4Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
285026701335.049.424.7New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
285126701335.079.839.9Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
285213351335.029.929.9Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
285313351335.043.643.6The frailty syndrome: definition and natural history. Qian-Li XueClin Geriatr Med201121093718No
285440041334.794.831.6Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
285513341334.050.750.7Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
285613341334.046.246.2Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
285713341334.027.727.7Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
285826681334.058.129.1Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
285913341334.050.050.0Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
286040001333.3120.540.2Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
286126661333.0100.050.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
286213331333.032.532.5Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
286326661333.073.636.8Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
286426661333.093.446.7Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde TheryCell201626967288No
286539991333.0211.070.3Improved metagenomic analysis with Kraken 2. Derrick E Wood, Jennifer Lu, Ben LangmeadGenome Biol201931779668Yes
286626651332.564.232.1Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
286713321332.029.829.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
286813321332.034.934.9Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
286913311331.033.433.4Supported membranes: scientific and practical applications. E SackmannScience19968539599No
287026621331.052.226.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
287113311331.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BERKSONBiometrics194621001024Yes
287226611330.578.339.1Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
287326611330.559.829.9Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
287453201330.0129.632.4Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
287513301330.024.724.7Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
287613301330.034.634.6The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
287713301330.026.926.9The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
287813301330.030.030.0Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
287953201330.0132.933.2Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
288026591329.550.425.2Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
288113291329.055.155.1A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
288213291329.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
288313291329.030.130.1Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
288453151328.8122.030.5Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar von Heijne, Soren BrunakJ Mol Biol200415223320Yes
288526561328.059.929.9Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
288613281328.022.622.6Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
288713281328.028.828.8Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
288826561328.056.928.4Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
288913281328.037.537.5Plant productivity and environment. J S BoyerScience198217808529Yes
289026551327.555.227.6The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
289113271327.056.456.4Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
289226541327.090.945.5Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
289313271327.00.00.0A simple objective technique for measuring flexibility in thinking. E A BERGJ Gen Psychol194818889466Yes
289413261326.035.635.6Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
289513261326.075.875.8Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. Janice M MorseQual Health Res201526184336Yes
289613261326.066.766.7Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Dimitrios TsikasAnal Biochem201727789233No
289739771325.791.930.6Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Ronnback, Elisabeth HanssonNat Rev Neurosci200616371949No
289826511325.567.333.6Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
289939751325.096.232.1The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
290013251325.036.136.1The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
290113251325.031.731.7Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
290213251325.035.035.0The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
290313241324.022.022.0Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
290426471323.564.932.5Interneurons of the hippocampus. T F Freund, G BuzsakiHippocampus19968915675No
290513231323.047.147.1The case for motivated reasoning. Z KundaPsychol Bull19902270237No
290626461323.045.822.9DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
290713231323.033.233.2Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
290826461323.073.336.6Accurate and robust brain image alignment using boundary-based registration. Douglas N Greve, Bruce FischlNeuroimage200919573611Yes
290939661322.0163.554.5Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
291026441322.077.538.8The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
291113221322.043.243.2The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
291266091321.8161.632.3Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
291326431321.568.234.1A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
291426431321.579.739.9Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
291513211321.032.232.2The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
291613211321.034.034.0The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
291713211321.00.00.0Intra-sexual selection in Drosophila. A J BATEMANHeredity (Edinb)194818103134Yes
291826411320.557.828.9Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
291926401320.040.420.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
292013201320.059.159.1Body Mass Index: Obesity, BMI, and Health: A Critical Review. Frank Q NuttallNutr Today201527340299Yes
292113201320.061.061.0Embracing the unknown: disentangling the complexities of the soil microbiome. Noah FiererNat Rev Microbiol201728824177No
292213191319.052.552.5Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
292326381319.059.629.8Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
292413191319.044.844.8Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
292539561318.7115.538.5The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
292626361318.083.141.5Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
292713181318.026.226.2Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
292813171317.031.131.1Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
292952681317.0135.233.8Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
293013171317.053.653.6Overview of the IL-1 family in innate inflammation and acquired immunity. Charles A DinarelloImmunol Rev201829247995No
293178991316.5224.537.4The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
293226331316.565.933.0Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
293313161316.037.237.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
293426321316.066.133.0Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
293526311315.546.623.3Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
293626301315.071.535.8Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
293726301315.023.811.9Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
293813151315.061.461.4New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
293913151315.037.837.8Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
294013151315.025.225.2Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
294139441314.7104.634.9Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Gunter Oberdorster, Eva Oberdorster, Jan OberdorsterEnviron Health Perspect200516002369No
294213141314.035.435.4The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
294326281314.0106.753.4Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
294426271313.543.621.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
294539401313.3105.635.2Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
294626251312.567.833.9Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
2947144341312.2394.735.9International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
294813121312.034.434.4Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
294913121312.027.427.4Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
295026241312.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A EDMONDSON, P E STEINERCancer195413160935Yes
295126231311.549.524.8Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
295213111311.067.467.4Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
295326221311.055.227.6Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
295413111311.023.123.1CD95's deadly mission in the immune system. P H KrammerNature200011048730No
295552421310.5107.326.8Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
295626211310.554.127.1Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
295739311310.3121.240.4Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
295813101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F SCHOLANDERJ Biol Chem194720281644Yes
295939271309.0173.157.7In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
296026181309.059.329.6Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
296113091309.039.539.5Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
296213091309.030.730.7Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
296326181309.061.330.6Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
296439261308.795.031.7Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
296526171308.563.031.5The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
296613081308.026.726.7The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
296726161308.0117.959.0An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Jesper L R Andersson, Stamatios N SotiropoulosNeuroimage201626481672Yes
296826151307.556.628.3Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
296926141307.050.125.1CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
297065351307.0180.136.0Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
297113071307.038.038.0Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
297226141307.0110.955.5Activation of apoptosis signalling pathways by reactive oxygen species. Maureen Redza-Dutordoir, Diana A Averill-BatesBiochim Biophys Acta201627646922No
297313061306.043.343.3Bee and wasp venoms. E HabermannScience19724113805No
297413061306.017.517.5The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
297513061306.031.031.0Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
297613061306.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FARRJ Infect Dis195813611294Yes
297713061306.028.628.6Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
297826121306.087.944.0Inflammasomes: mechanism of assembly, regulation and signalling. Petr Broz, Vishva M DixitNat Rev Immunol201627291964No
297926111305.551.025.5ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
298013051305.032.332.3Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
298126091304.577.238.6An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
298226091304.599.749.9Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
298339131304.390.830.3METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Goncalo R AbecasisBioinformatics201020616382Yes
298413041304.030.830.8Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
298526081304.044.922.4Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
298613031303.083.883.8The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
298713031303.034.734.7Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
298839091303.0132.144.0The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
298913031303.030.230.2Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
299026051302.532.416.2A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H VANDENDOOL, P D KRATZJ Chromatogr196314062605Yes
299139071302.3109.736.6HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
299213021302.028.828.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
299326041302.068.834.4Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
299426031301.583.641.8Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
299513011301.034.634.6Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
299613011301.032.632.6Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
299713011301.00.00.0Agammaglobulinemia. O C BRUTONPediatrics195214929630Yes
299813011301.026.826.8VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
299913011301.030.230.2Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
300013011301.041.841.8Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
300113011301.053.353.3The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
300226011300.580.040.0The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
300313001300.045.745.7The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
300425981299.052.826.4The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
300512991299.043.443.4Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
300612991299.026.926.9Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
300712991299.026.026.0The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
300812991299.028.728.7Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
300938971299.096.332.1Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
301064941298.8313.762.7Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
301177921298.7311.351.9Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark WymerHepatology201626707365No
301212981298.039.239.2Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
301325961298.0137.468.7Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R GUILLARD, J H RYTHERCan J Microbiol196213902807Yes
301412981298.028.728.7Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
301525961298.0115.857.9Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Florian R Greten, Sergei I GrivennikovImmunity201931315034No
301625951297.578.639.3A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
301712971297.046.246.2Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
301812971297.030.930.9Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
301912971297.033.633.6The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
302012971297.034.734.7Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
302125931296.573.436.7Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
302238891296.390.630.2Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
302312961296.00.00.0A production of amino acids under possible primitive earth conditions. S L MILLERScience195313056598Yes
302425911295.556.828.4Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
302512951295.042.142.1Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
302612951295.030.930.9Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
302712951295.032.232.2Drug delivery and targeting. R LangerNature19989579855No
302825901295.065.432.7BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
302912951295.038.138.1A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
303025891294.566.733.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
303112941294.032.132.1Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
303212941294.028.628.6Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
303325871293.548.024.0The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
303425871293.544.322.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
303525861293.095.047.5The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
303612931293.032.632.6Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
303712931293.024.324.3Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
303812931293.044.244.2Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjostromJ Intern Med201323163728No
303912921292.042.342.3Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
304012921292.030.130.1Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
304138761292.088.829.6Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
304212921292.033.633.6Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
304325831291.598.849.4A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
304425831291.562.031.0Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
304525821291.048.324.1Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
304638711290.395.831.9Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
304712901290.044.044.0Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
304825801290.049.424.7Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
304912901290.024.824.8Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
305025801290.058.929.4ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoit D'Autreaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
305125801290.0170.485.2The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
305212891289.029.429.4Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
305312891289.039.439.4Somatostatin. S ReichlinN Engl J Med19836139753No
305412891289.027.327.3S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
305525761288.089.945.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
305612881288.036.936.9Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BoyumScand J Clin Lab Invest Suppl19684179066Yes
305712881288.036.136.1Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
305812881288.025.025.0Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
305912881288.034.034.0The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
306025761288.0108.954.5Principal component analysis: a review and recent developments. Ian T Jolliffe, Jorge CadimaPhilos Trans A Math Phys Eng Sci201626953178No
306125741287.060.730.4Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
306212871287.014.314.3A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
306312871287.029.829.8Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
306425741287.082.341.1Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
306512871287.040.540.5Drug transport across the blood-brain barrier. William M PardridgeJ Cereb Blood Flow Metab201222929442No
306612861286.038.838.8Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
306712861286.029.429.4Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
306825721286.075.437.7Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
306925721286.065.532.8A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
307012861286.038.338.3Determining association constants from titration experiments in supramolecular chemistry. Pall ThordarsonChem Soc Rev201121125111Yes
307125711285.573.937.0Crosstalk of reactive oxygen species and NF-κB signaling. Michael J Morgan, Zheng-gang LiuCell Res201121187859No
307225711285.582.641.3Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
307338561285.3106.835.6Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681Yes
307412851285.058.758.7A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
307512851285.037.937.9Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
307638551285.0107.835.9Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
3077128441284.4310.731.1Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
307812831283.025.325.3Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
307925651282.513.56.8Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J TODARO, H GREENJ Cell Biol196313985244Yes
308025651282.565.232.6Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
308125641282.076.038.0Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
308225631281.559.229.6Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
308338441281.3175.158.4Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
308425621281.066.333.1Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundstrom, K NilssonInt J Cancer1976178611Yes
308525621281.067.333.6Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
308612811281.029.429.4Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
308725621281.051.525.8Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
308812811281.034.834.8Depression in the elderly. George S AlexopoulosLancet200515936426No
308976861281.0270.145.0ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos SimmerlingJ Chem Theory Comput201526574453Yes
309025611280.549.024.5Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
3091115231280.3279.431.0Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
309289621280.3254.236.3pROC: an open-source package for R and S+ to analyze and compare ROC curves. Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus MullerBMC Bioinformatics201121414208Yes
309312801280.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KALCKARJ Biol Chem194720285041Yes
309412801280.046.046.0Epidemiology and risk factors for IBD. Ashwin N AnanthakrishnanNat Rev Gastroenterol Hepatol201525732745No
309525591279.554.527.2The Polycomb complex PRC2 and its mark in life. Raphael Margueron, Danny ReinbergNature201121248841No
309612791279.030.230.2A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
309712791279.031.431.4Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
309812791279.00.00.0The antidiuretic hormone and the factors which determine its release. E B VERNEYProc R Soc Lond B Biol Sci194718918876Yes
309976731278.8169.728.3Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
310025571278.570.335.1Mitochondria: in sickness and in health. Jodi Nunnari, Anu SuomalainenCell201222424226No
310138351278.392.130.7Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
310251111277.8143.936.0Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
310325541277.057.328.6Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
310412771277.030.930.9The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
310512771277.039.239.2Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
310663811276.2295.159.0Using the framework method for the analysis of qualitative data in multi-disciplinary health research. Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi RedwoodBMC Med Res Methodol201324047204Yes
310712761276.027.627.6Brain tumors. L M DeAngelisN Engl J Med200111150363No
310812761276.026.826.8r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
310912761276.034.334.3Rethinking schizophrenia. Thomas R InselNature201021068826No
311038271275.7113.037.7Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
311112751275.061.161.1Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
311212751275.025.825.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
311312751275.026.526.5Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
311425491274.557.028.5Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
311525481274.050.725.4A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
311612741274.050.150.1The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
311712741274.031.631.6Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
311812741274.070.470.4The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A ROSEBull World Health Organ196213974778Yes
311925471273.565.032.5Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
312012731273.045.945.9The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
312125461273.053.726.9Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
312212731273.051.351.3Cystic fibrosis. J Stuart ElbornLancet201627140670No
312325451272.550.725.4TM-align: a protein structure alignment algorithm based on the TM-score. Yang Zhang, Jeffrey SkolnickNucleic Acids Res200515849316Yes
312425451272.569.134.5Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
312589061272.3222.531.8Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
312638171272.386.028.7Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
312712721272.038.738.7The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
312812721272.073.173.1Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WINTERNature196214007593Yes
312912721272.037.937.9Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
313025431271.561.830.9Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
313112711271.030.230.2Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
313225421271.077.939.0Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
313312711271.026.726.7Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
313412711271.027.827.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
313525421271.050.425.2NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
313612711271.040.540.5Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
313725411270.558.229.1Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
313825401270.080.440.2Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
313912701270.020.920.9Antigen receptor tail clue. M RethNature19892927501Yes
314012701270.036.036.0Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
3141139701270.0323.529.4New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
314212701270.026.726.7Human papillomavirus and cervical cancer. Eileen M BurdClin Microbiol Rev200312525422No
314312701270.025.225.2Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
314425381269.0101.450.7The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Naatanen, T PictonPsychophysiology19873615753Yes
314512691269.032.232.2Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
314612681268.033.733.7Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
314725361268.052.326.1Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
314812681268.046.346.3Substance P. B PernowPharmacol Rev19836196797No
314963371267.4238.647.7Frailty in elderly people. Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth RockwoodLancet201323395245No
315025341267.084.242.1A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
315112671267.032.132.1AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
315225331266.572.636.3Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
315312661266.022.222.2Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
315425321266.051.925.9Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
315525311265.566.933.5Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
315625311265.565.032.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
315725301265.077.338.6Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
315812641264.034.534.5Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
315925281264.048.124.1Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
316012641264.022.622.6Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
316150551263.8115.929.0Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
316237901263.3114.138.0PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
316325251262.557.628.8Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
316412621262.040.040.0Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
316512621262.048.248.2A simple method for determination of serum catalase activity and revision of reference range. L GothClin Chim Acta19912029780Yes
316612621262.025.725.7Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
316712621262.034.934.9High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
316812621262.030.330.3Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
316912621262.050.650.6Mediation Analysis: A Practitioner's Guide. Tyler J VanderWeeleAnnu Rev Public Health201626653405No
317025241262.0106.953.5The role of inflammation in depression: from evolutionary imperative to modern treatment target. Andrew H Miller, Charles L RaisonNat Rev Immunol201626711676No
317150461261.5131.432.9Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Madler, Ning LiScience200616456071No
317212611261.021.421.4Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
317312611261.036.036.0Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
317412611261.029.529.5Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
317512611261.020.420.4Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
317625221261.049.724.9Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
317725221261.069.334.6Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
317825211260.576.738.4Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
317912601260.027.927.9Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
318012601260.039.139.1Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
318112601260.024.524.5Searching for genetic determinants in the new millennium. N J RischNature200010866211No
318212601260.035.935.9Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
318325201260.065.232.6Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
318412591259.025.625.6Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
318512591259.032.032.0A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
318612591259.024.824.8Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
318725171258.5103.351.6Designing hydrogels for controlled drug delivery. Jianyu Li, David J MooneyNat Rev Mater201629657852Yes
318812581258.025.625.6SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
318912581258.026.926.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
319012581258.023.923.9A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
319125161258.057.028.5ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
319237731257.791.130.4The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
319325121256.091.445.7The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
319425121256.068.534.2Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
319512561256.031.331.3Apoptosis. J J CohenImmunol Today19938466628No
319612561256.032.032.0Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
319712561256.024.924.9Searching for intellectual turning points: progressive knowledge domain visualization. Chaomei ChenProc Natl Acad Sci U S A200414724295Yes
319837681256.087.829.3Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
319925121256.077.138.5Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
320025111255.560.830.4Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
320112551255.036.436.4Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
320212551255.025.225.2Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
320312551255.026.426.4How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
320412551255.033.233.2Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
3205100381254.8439.755.0Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K ChandaNat Commun201930944313Yes
320612541254.042.042.0Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
320712541254.00.00.0A modification of receptor theory. R P STEPHENSONBr J Pharmacol Chemother195613383117Yes
320812541254.026.326.3Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
320912531253.033.933.9Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
321012531253.060.560.5Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
321112531253.030.830.8Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
321212531253.033.333.3MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
321375171252.8161.827.0Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
321425051252.557.628.8DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
321525051252.597.048.5Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
321612521252.035.435.4A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
321712521252.024.524.5STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
321812521252.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MEDAWARBr J Exp Pathol194818865105Yes
321925041252.069.534.8Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
322012511251.022.822.8Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
322112511251.022.622.6Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
322212511251.031.531.5Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
322312511251.027.427.4Viruses in the sea. Curtis A SuttleNature200516163346No
322437531251.0105.335.1SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stephane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
322525011250.552.226.1Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
322612501250.044.344.3Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
322712501250.032.432.4Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
322812501250.046.046.0Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
322912491249.025.925.9The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
323024971248.548.324.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
323124971248.562.731.4Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
323212481248.024.624.6Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
323312481248.062.662.6Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
323412481248.029.129.1Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
323537431247.796.332.1Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
323624951247.566.133.0Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
323724951247.552.526.2Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
323812471247.053.853.8Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
323912471247.032.332.3Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
324012471247.030.130.1Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
324112461246.046.446.4A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
324224921246.064.032.0Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
324312461246.027.327.3Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
324424921246.048.124.1Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
324512461246.00.00.0Sequential tests for the detection of linkage. N E MORTONAm J Hum Genet195513258560Yes
324612451245.015.715.7The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
324712451245.045.045.0Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
324812451245.039.839.8Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
324912451245.028.628.6ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
325012441244.028.328.3Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
325112441244.030.630.6Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
325212441244.030.630.6An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
325387061243.7263.037.6Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
325424871243.560.930.4Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
325512431243.041.941.9How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
325612431243.036.936.9Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
325712431243.037.937.9The inflammatory response in myocardial injury, repair, and remodelling. Nikolaos G FrangogiannisNat Rev Cardiol201424663091No
325824841242.0118.259.1Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
325912421242.046.146.1Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
326012421242.022.422.4Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
326112421242.023.423.4Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
326237261242.0233.277.7How to perform a meta-analysis with R: a practical tutorial. Sara Balduzzi, Gerta Rucker, Guido SchwarzerEvid Based Ment Health201931563865Yes
326324831241.589.444.7Comparative Protein Structure Modeling Using MODELLER. Benjamin Webb, Andrej SaliCurr Protoc Bioinformatics201627322406Yes
326424831241.590.545.2Tumour heterogeneity and resistance to cancer therapies. Ibiayi Dagogo-Jack, Alice T ShawNat Rev Clin Oncol201829115304No
326512411241.015.415.4Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M VAN ROSSUMArch Int Pharmacodyn Ther196313996119Yes
326649631240.8259.664.9Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. Shaoqing Ren, Kaiming He, Ross Girshick, Jian SunIEEE Trans Pattern Anal Mach Intell201727295650Yes
326774451240.8275.445.9GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin ZhangNucleic Acids Res201728407145Yes
326862031240.6112.922.6The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
326924811240.572.136.0The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
327024811240.567.733.9Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
327112401240.034.834.8The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
327261981239.6191.538.3Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
327324791239.591.345.6Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
327474351239.2135.122.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
327524781239.067.533.8Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
327624781239.053.226.6The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N AMES, D T DUBINJ Biol Chem196013793161Yes
327712391239.023.123.1Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
327861921238.4165.833.2Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
327912381238.055.455.4Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
328012381238.036.536.5Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
328112381238.025.225.2Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
328212381238.039.339.3Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
328324751237.589.644.8Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
328412371237.036.936.9MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
328512371237.037.537.5Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
328612371237.036.036.0The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
328712371237.026.526.5Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
328812371237.021.221.2NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
328912371237.030.130.1Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
329012371237.035.035.0pegas: an R package for population genetics with an integrated-modular approach. Emmanuel ParadisBioinformatics201020080509Yes
329112371237.033.133.1Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
329212361236.033.433.4Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
329361791235.8204.740.9Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
329437071235.773.824.6Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
329524711235.539.319.6A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
329612351235.024.824.8Evolution of ageing. T B KirkwoodNature1977593350Yes
329712351235.026.826.8Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
329824691234.550.025.0Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
329912341234.025.325.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
330012341234.024.224.2The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. P StothardBiotechniques200010868275Yes
330112341234.033.233.2Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
330212341234.029.329.3Identifying and characterizing binding sites and assessing druggability. Thomas A HalgrenJ Chem Inf Model200919434839Yes
330324661233.083.841.9A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
330412331233.058.958.9The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
330512331233.027.327.3Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
330612331233.020.820.8Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
330712331233.029.129.1Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
330824651232.551.925.9Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
330924651232.566.233.1Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Marie Cargnello, Philippe P RouxMicrobiol Mol Biol Rev201121372320No
331012321232.052.752.7Review of the psychometric evidence of the perceived stress scale. Eun-Hyun LeeAsian Nurs Res (Korean Soc Nurs Sci)201225031113Yes
331124631231.594.347.1Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Michael A Gimbrone, Guillermo Garcia-CardenaCirc Res201626892962No
331212311231.025.725.7Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
331336911230.3127.842.6Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Dmitry B Zorov, Magdalena Juhaszova, Steven J SollottPhysiol Rev201424987008No
331412301230.033.933.9Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
331524601230.069.034.5Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
331612301230.031.731.7Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
331736891229.770.923.6SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
331812291229.057.257.2Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
331912291229.031.931.9Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
332024581229.081.840.9Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
332124581229.063.131.6Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
332212291229.031.231.2The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
332312291229.042.942.9Type 2 inflammation in asthma--present in most, absent in many. John V FahyNat Rev Immunol201525534623No
332436851228.3122.941.0Ecological momentary assessment. Saul Shiffman, Arthur A Stone, Michael R HuffordAnnu Rev Clin Psychol200818509902No
332573701228.3163.127.2Enzymatic assembly of DNA molecules up to several hundred kilobases. Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O SmithNat Methods200919363495Yes
332636851228.392.330.8Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
332712281228.028.428.4Growth factors and cancer. S A AaronsonScience19911659742No
332812281228.025.025.0MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
332912281228.028.928.9Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
333036841228.074.824.95-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
333112281228.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BUONOCOREJ Dent Res195513271655Yes
333224561228.080.840.4Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
333312281228.051.251.2Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Daniel J DruckerCell Metab201829617641No
333436831227.7143.047.7Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Antonio Ayala, Mario F Munoz, Sandro ArguellesOxid Med Cell Longev201424999379No
333524551227.567.833.9Regulation of type I interferon responses. Lionel B Ivashkiv, Laura T DonlinNat Rev Immunol201424362405No
333612271227.030.530.5Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
333712271227.033.633.6Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
333824541227.054.827.4The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
333924541227.057.028.5Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. In Suk Joung, Thomas E CheathamJ Phys Chem B200818593145Yes
334012271227.047.247.2Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
334124531226.553.626.8Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
334298121226.5298.537.3Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S MarksAm J Prev Med19989635069Yes
334336791226.3103.134.4A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
334412261226.023.723.7Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
334512261226.026.026.0Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
334624521226.048.624.3The mammalian unfolded protein response. Martin Schroder, Randal J KaufmanAnnu Rev Biochem200515952902No
334736781226.095.932.0FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Morgan N Price, Paramvir S Dehal, Adam P ArkinMol Biol Evol200919377059Yes
334812261226.041.441.4Human milk oligosaccharides: every baby needs a sugar mama. Lars BodeGlycobiology201222513036No
334912251225.022.122.1Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
335012241224.025.125.1Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
335112241224.023.623.6Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
335224471223.572.436.2Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
335324471223.587.944.0MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Martin Steinegger, Johannes SodingNat Biotechnol201729035372Yes
335436701223.3111.237.1Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
335512231223.030.330.3Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsakiNeuroscience19892687720No
335612231223.058.558.5ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
335724461223.057.728.9Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
335836681222.760.320.1A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, Rene Bernards, Reuven AgamiScience200211910072Yes
335912221222.025.725.7Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
336036661222.0101.934.0Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
336124431221.554.027.0Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
336224431221.564.032.0Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
336324421221.082.341.1The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
336424421221.071.535.8Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
336512211221.023.723.7Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
336612211221.022.522.5IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
336748821220.5139.234.8Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
336812201220.040.640.6The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
336912201220.028.228.2The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
337012201220.028.028.0Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
337112201220.00.00.0Voluntary strength and fatigue. P A MERTONJ Physiol195413152698Yes
337212201220.032.132.1What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
3373121951219.5390.639.1The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
337412191219.0108.7108.7The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
337512191219.073.873.8Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
337624371218.526.113.1The Aggregation Of Blood Platelets. G V BORN, M J CROSSJ Physiol196314056485Yes
337712181218.034.834.8The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. John DuncanTrends Cogn Sci201020171926No
337836531217.772.224.1Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
337936531217.793.431.1Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
338024351217.561.130.6Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
338112171217.032.532.5Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
338224341217.069.234.6The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
338312161216.029.029.0Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
338424321216.087.843.9Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
338512161216.024.324.3Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
338612161216.033.333.3ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
338724311215.552.326.1microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
338824301215.062.031.0Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
3389133611214.6245.522.3Model-based analysis of ChIP-Seq (MACS). Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley LiuGenome Biol200818798982Yes
339024291214.5190.895.4Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
339112141214.063.363.3A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
339212141214.048.348.3Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
339312141214.032.732.7Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
339424281214.068.434.2Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
339524271213.5104.752.4Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
339624271213.534.917.4High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
339736401213.3126.342.1Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
339812131213.029.029.0The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
339948521213.090.622.6Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
340012131213.022.522.5Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
340124251212.557.428.7The regulation of IL-10 production by immune cells. Margarida Saraiva, Anne O'GarraNat Rev Immunol201020154735No
340212121212.075.475.4Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
340324241212.064.132.0Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
340412121212.026.226.2Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
340512121212.030.230.2Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
340624241212.076.338.1Toll-like receptor signaling pathways. Takumi Kawasaki, Taro KawaiFront Immunol201425309543No
340712111211.027.927.9Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
340824221211.045.922.9Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
340912111211.031.631.6Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532Yes
341024211210.542.521.2Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
341136311210.380.226.7Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
341212101210.052.152.1Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
341312101210.035.935.9The mysteries of lipoprotein(a). G UtermannScience19892530631No
341412101210.050.250.2A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
341512101210.029.729.7The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
341624201210.050.425.2Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
341712101210.030.830.8Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
341824181209.0123.461.7The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
341936271209.081.427.1Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernan, B BrumbackEpidemiology200010955408Yes
342012081208.025.325.3Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
342112081208.053.353.3Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
342212071207.033.033.0What is synergy? M C BerenbaumPharmacol Rev19892692037No
342312071207.026.626.6The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
342412071207.038.438.4Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
342512071207.042.042.0Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
342624141207.059.029.5Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
342712071207.025.425.4The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
342824141207.051.925.9Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
342912071207.029.629.6Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
343012061206.037.837.8The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
343124121206.097.348.6Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
343212061206.041.341.3Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
343312061206.033.733.76-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
343412061206.017.417.4The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E HOPE-SIMPSONProc R Soc Med196514267505Yes
343512061206.032.232.2On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
343612061206.033.433.4Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Masabumi ShibuyaGenes Cancer201122866201Yes
343772351205.8171.428.6Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, Lancet200212493255Yes
343824111205.552.726.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
343924101205.087.743.9Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
344024101205.068.634.3Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
344112051205.018.518.5Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
344212051205.019.219.2Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
344312051205.029.629.6Optogenetics. Karl DeisserothNat Methods201121191368Yes
344460221204.4211.242.2Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
344536131204.3119.139.7Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
344612041204.049.049.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
344712041204.028.528.5Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" F D HaldanePhys Rev Lett198810038961Yes
344824081204.044.222.1Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
344924081204.074.337.1Infernal 1.1: 100-fold faster RNA homology searches. Eric P Nawrocki, Sean R EddyBioinformatics201324008419Yes
345024081204.091.245.6Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Jerome Galon, Daniela BruniNat Rev Drug Discov201930610226No
345124071203.543.621.8The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
345224071203.568.034.0Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
345324071203.598.649.3Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Douglas J Morrison, Tom PrestonGut Microbes201626963409No
345436101203.391.630.5Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
345512031203.021.321.3Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
345612031203.026.526.5The columnar organization of the neocortex. V B MountcastleBrain19979153131No
345712031203.032.732.7The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
345824061203.052.726.4Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794Yes
345912031203.022.922.9Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
346012031203.040.940.9Considerations in determining sample size for pilot studies. Melody A HertzogRes Nurs Health200818183564No
346136071202.3110.336.8The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
346212021202.029.729.7Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
346312021202.037.837.8Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
346436061202.0166.955.6Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
346512021202.020.420.4Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
346672111201.8243.640.6The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
346724031201.569.534.8Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
346860071201.4140.728.1Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
346912011201.036.636.6Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
347012011201.058.458.4Osseointegration and its experimental background. P I BranemarkJ Prosthet Dent19836352924No
347112011201.010.010.0A New Serum Type System In Man--The Lp System. K BERGActa Pathol Microbiol Scand196314064818Yes
347284041200.6543.077.6IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert LanfearMol Biol Evol202032011700Yes
347324011200.577.338.6Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
347436001200.085.628.5Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
347524001200.048.024.0Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
347612001200.030.330.3The quantum internet. H J KimbleNature200818563153Yes
347724001200.094.747.4Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. T J Cole, T LobsteinPediatr Obes201222715120Yes
347823981199.048.224.1Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
347911991199.029.229.2Overview of the immune response. David D ChaplinJ Allergy Clin Immunol201020176265No
3480107881198.7352.039.1A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
3481119811198.1263.326.3Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus SchultenJ Comput Chem200516222654Yes
348211981198.062.862.8The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
348335941198.071.723.9Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
348411981198.032.832.8On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
348523961198.056.528.2Interaction revisited: the difference between two estimates. Douglas G Altman, J Martin BlandBMJ200312543843No
348623961198.056.628.3Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
348711981198.037.237.2Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan St B T EvansAnnu Rev Psychol200818154502No
348847921198.0123.230.8Gene ontology analysis for RNA-seq: accounting for selection bias. Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia OshlackGenome Biol201020132535Yes
348911981198.044.544.5The angular gyrus: multiple functions and multiple subdivisions. Mohamed L SeghierNeuroscientist201322547530No
349011981198.040.140.1DREADDs for Neuroscientists. Bryan L RothNeuron201626889809No
349123951197.546.423.2Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
349223951197.549.624.8Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
349323951197.548.924.4Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
349435921197.3180.260.1Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
349523941197.0105.252.6Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
349611971197.028.328.3Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
349711971197.045.145.1Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
349811971197.039.439.4beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
349911971197.025.125.1G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
350011971197.034.734.7On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
350183781196.9160.122.9Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
350247871196.8106.526.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
350311961196.040.040.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
350411961196.033.333.3Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Rakesh K JainCancer Cell201425517747No
350523911195.591.845.9Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. N L Glass, G C DonaldsonAppl Environ Microbiol19957747954Yes
350647821195.5114.328.6Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
350711951195.036.436.4Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
350811951195.027.427.4Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
350923901195.055.927.9Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
351011951195.033.533.5Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
351135851195.0120.240.1Social relationships and mortality risk: a meta-analytic review. Julianne Holt-Lunstad, Timothy B Smith, J Bradley LaytonPLoS Med201020668659No
351271661194.3149.925.0Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
351311941194.044.044.0Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
351411941194.033.633.6Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
351511941194.020.920.9Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
351623881194.063.631.8Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
351723871193.551.825.9Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
351823861193.050.525.2Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
351911931193.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C CHANGNature195114882325Yes
352011931193.030.730.7Inflammation 2010: new adventures of an old flame. Ruslan MedzhitovCell201020303867No
352111931193.039.439.4What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
352211931193.031.831.8Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
352323851192.595.547.8Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
352423851192.547.823.9The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
352523851192.552.426.2Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
352611921192.034.034.0Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
352711921192.023.523.5The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DUNCOMBEClin Chim Acta196414122498Yes
352811921192.027.227.2Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
352923841192.050.125.1Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
353047681192.0121.530.4Mussel-inspired surface chemistry for multifunctional coatings. Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B MessersmithScience200717947576Yes
353111921192.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
353211921192.044.444.4Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). F BerenbaumOsteoarthritis Cartilage201323194896No
353323831191.537.518.8Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
353411911191.068.368.3Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
353511911191.011.411.4Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
353611911191.032.032.0Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
353711911191.022.022.0Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
353811911191.030.730.7A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
353923821191.077.538.8The gut microbiota--masters of host development and physiology. Felix Sommer, Fredrik BackhedNat Rev Microbiol201323435359No
354023821191.089.945.0The Human Intestinal Microbiome in Health and Disease. Susan V Lynch, Oluf PedersenN Engl J Med201627974040No
354135721190.7176.458.8Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Yan Zheng, Sylvia H Ley, Frank B HuNat Rev Endocrinol201829219149No
354223811190.5201.7100.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
354335711190.393.531.2A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
354411901190.022.122.1VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
354511901190.023.023.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B ASHWORTHPractitioner196414143329Yes
354611901190.031.031.0Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
354711901190.038.038.0Epidemiology of heart failure. Veronique L RogerCirc Res201323989710No
354823801190.087.443.7OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. David M Emms, Steven KellyGenome Biol201526243257Yes
354923801190.0101.850.9Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Luigi Ferrucci, Elisa FabbriNat Rev Cardiol201830065258No
355011891189.030.830.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
355123781189.074.837.4Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
355211891189.058.558.5Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Hector F Escobar-MorrealeNat Rev Endocrinol201829569621No
3553166311187.9350.125.0Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
355423751187.564.332.1Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
355523751187.573.136.5Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
355659361187.2190.838.2Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
355711871187.056.356.3The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
355847481187.0109.127.3Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
355911871187.044.044.0Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
356011871187.035.135.1Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
356111871187.027.027.0Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
356211871187.042.742.7Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Georgia SalantiRes Synth Methods201226062083Yes
356323721186.0110.755.4Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
356411861186.034.334.3Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
356523721186.039.819.9A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
356611861186.028.128.1Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. R ZahorecBratisl Lek Listy200111723675Yes
356711861186.026.426.4Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
356835581186.074.925.0Population structure and eigenanalysis. Nick Patterson, Alkes L Price, David ReichPLoS Genet200617194218Yes
356923721186.063.831.9Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
357011861186.053.953.9A decade of immune-checkpoint inhibitors in cancer therapy. Caroline RobertNat Commun202032732879Yes
357135571185.775.725.2Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
357259281185.6232.946.6KEGG: new perspectives on genomes, pathways, diseases and drugs. Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae MorishimaNucleic Acids Res201727899662Yes
357323711185.549.524.8Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
357411851185.038.838.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
357511851185.037.037.0Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
357611851185.034.834.8The mental health continuum: from languishing to flourishing in life. Corey L M KeyesJ Health Soc Behav200212096700Yes
357711851185.028.728.7Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
357811851185.027.127.1Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Andrey A ShabalinBioinformatics201222492648Yes
357923701185.081.040.5ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Tauno Metsalu, Jaak ViloNucleic Acids Res201525969447Yes
358011841184.039.139.1Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
358111841184.029.229.2Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
358211841184.023.223.2Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
358311841184.030.130.1Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
358435511183.796.432.1Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
358523671183.594.347.1A real-time QRS detection algorithm. J Pan, W J TompkinsIEEE Trans Biomed Eng19853997178Yes
358623671183.557.928.9Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
358723671183.551.125.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
358811831183.024.524.5Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
358911831183.029.229.2Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
359011831183.00.00.0The powerful placebo. H K BEECHERJ Am Med Assoc195513271123Yes
359111831183.032.132.1The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
359235481182.770.623.5Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
359323651182.542.821.4Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
359411821182.026.026.0Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
359511821182.034.634.6Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
359623631181.572.836.4Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
359723621181.064.432.2The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
359811811181.026.726.7Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
359911811181.030.630.6Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
360023611180.577.038.5Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
360111801180.036.836.8Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
360223601180.084.842.4The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
360311801180.052.852.8Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
360411801180.032.732.7Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. J C MorrisInt Psychogeriatr19979447441Yes
360511801180.021.321.3The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
360611801180.025.925.9Sjögren's syndrome. Robert I FoxLancet200516039337No
360711801180.028.228.2Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
360835401180.0106.235.4Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Irith Wiegand, Kai Hilpert, Robert E W HancockNat Protoc200818274517Yes
360911801180.024.224.2Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
361011801180.033.933.9Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BunzliChem Rev201020151630No
361111801180.035.635.6The Danish Cancer Registry. Marianne Lundkjaer GjerstorffScand J Public Health201121775350Yes
361211801180.045.645.6Vitamin D metabolism, mechanism of action, and clinical applications. Daniel D BikleChem Biol201424529992No
361311791179.053.053.0Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
361423581179.056.228.1The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
361535351178.389.930.0Fluorine in pharmaceuticals: looking beyond intuition. Klaus Muller, Christoph Faeh, Francois DiederichScience200717901324No
361611781178.030.630.6Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
361711781178.023.723.7Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
361811781178.030.130.1Neural stimulation and recording electrodes. Stuart F CoganAnnu Rev Biomed Eng200818429704No
361911781178.026.326.3Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
362011781178.043.743.7A polarizing question: do M1 and M2 microglia exist? Richard M RansohoffNat Neurosci201627459405No
362123551177.557.028.5Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Sophia Y Lunt, Matthew G Vander HeidenAnnu Rev Cell Dev Biol201121985671No
362211771177.034.334.3Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
362311771177.033.433.4Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
362411771177.025.725.7Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
362511771177.041.141.1Autonomic nervous system activity in emotion: a review. Sylvia D KreibigBiol Psychol201020371374No
362623531176.550.525.2Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
362723521176.058.729.4Cancer epigenetics: from mechanism to therapy. Mark A Dawson, Tony KouzaridesCell201222770212No
362835281176.0172.457.5Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Mojtaba Vaismoradi, Hannele Turunen, Terese BondasNurs Health Sci201323480423No
362923511175.561.030.5The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Maria M Mihaylova, Reuben J ShawNat Cell Biol201121892142No
363023491174.585.042.5Gut microbiota, metabolites and host immunity. Michelle G Rooks, Wendy S GarrettNat Rev Immunol201627231050No
363111741174.031.831.8Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
363235221174.0112.937.6The Danish National Patient Register. Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka ReboljScand J Public Health201121775347Yes
363311741174.032.232.2Cyclin-dependent kinases. Marcos MalumbresGenome Biol201425180339No
363435211173.7134.344.8The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris BoshoffNature201829364287No
363523471173.566.933.5Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
363623471173.543.421.7NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
363735201173.399.633.2Macrophage biology in development, homeostasis and disease. Thomas A Wynn, Ajay Chawla, Jeffrey W PollardNature201323619691No
363811731173.026.126.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
363911731173.011.611.6Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
364011731173.039.539.5Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
364111731173.033.733.7Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
364223461173.049.224.6Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
364311731173.057.557.5Resin composite--state of the art. Jack L FerracaneDent Mater201121093034No
364411721172.051.851.8Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
364511711171.024.124.1Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
364611711171.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B REXEDJ Comp Neurol195214946260Yes
364711711171.039.639.6The pain self-efficacy questionnaire: Taking pain into account. Michael K NicholasEur J Pain200716446108Yes
364811711171.028.728.7Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
364911711171.038.838.8The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Peter C AustinStat Med201424122911Yes
365035121170.7141.447.1Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
365111701170.034.934.9Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
365211701170.045.545.5Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Laura J JulianArthritis Care Res (Hoboken)201122588767No
365311701170.029.529.5The complex world of WNT receptor signalling. Christof NiehrsNat Rev Mol Cell Biol201223151663No
365423401170.096.448.2The Tumor Microenvironment Innately Modulates Cancer Progression. Dominique C Hinshaw, Lalita A ShevdeCancer Res201931350295No
365558461169.2113.522.7Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
365611691169.042.642.6Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
365711691169.026.226.2The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
365811691169.034.734.7Chronic stress, drug use, and vulnerability to addiction. Rajita SinhaAnn N Y Acad Sci200818991954No
365981701167.1553.079.0TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui XiaMol Plant202032585190Yes
366011671167.024.624.6Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
366111671167.031.231.2Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
366211671167.032.132.1Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
366335001166.780.426.8Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Vinuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
366446661166.5207.251.8An ecological perspective on health promotion programs. K R McLeroy, D Bibeau, A Steckler, K GlanzHealth Educ Q19883068205No
366511661166.021.621.6The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
366611661166.020.520.5DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
366711661166.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
366811661166.042.842.8Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. Walter S LealAnnu Rev Entomol201323020622No
366923311165.562.231.1The diversity and biogeography of soil bacterial communities. Noah Fierer, Robert B JacksonProc Natl Acad Sci U S A200616407148Yes
367058261165.2261.552.3VSEARCH: a versatile open source tool for metagenomics. Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic MahePeerJ201627781170Yes
367111651165.035.135.1Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
367211651165.031.431.4Leishmaniasis. B L HerwaldtLancet199910513726No
367311651165.033.833.8Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
367411651165.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BROWNBiochem J195514389222Yes
367511651165.030.830.8Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Barry HalliwellPlant Physiol200616760481Yes
367623301165.059.029.5Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
367711641164.020.620.6Biogenic amines and the states of sleep. M JouvetScience19694303225No
367811641164.026.526.5Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
367911641164.034.834.8Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
368011641164.039.039.0Constructive and unconstructive repetitive thought. Edward R WatkinsPsychol Bull200818298268No
368123271163.569.334.6Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
368223271163.546.923.4Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
368311631163.030.330.3Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
368423261163.079.439.7Superoxide dismutases: I. Occurrence in higher plants. C N Giannopolitis, S K RiesPlant Physiol197716659839Yes
368511631163.00.00.0Knee joint changes after meniscectomy. T J FAIRBANKJ Bone Joint Surg Br194818894618Yes
368611631163.032.232.2Normal bone anatomy and physiology. Bart ClarkeClin J Am Soc Nephrol200818988698No
368711631163.035.235.2Staphylococcus epidermidis--the 'accidental' pathogen. Michael OttoNat Rev Microbiol200919609257No
368811631163.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BULBRINGBr J Pharmacol Chemother194620999334Yes
368934891163.098.532.8AMPK: a nutrient and energy sensor that maintains energy homeostasis. D Grahame Hardie, Fiona A Ross, Simon A HawleyNat Rev Mol Cell Biol201222436748No
369023261163.058.929.4Molecular mechanisms of T cell co-stimulation and co-inhibition. Lieping Chen, Dallas B FliesNat Rev Immunol201323470321No
369134881162.7135.445.1Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
369211621162.029.629.6Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
369323231161.589.644.8Shared decision making--pinnacle of patient-centered care. Michael J Barry, Susan Edgman-LevitanN Engl J Med201222375967Yes
369423221161.066.833.4Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
369511611161.027.227.2Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
369611611161.024.224.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
369711611161.029.329.3Gibberellin metabolism and its regulation. Shinjiro YamaguchiAnnu Rev Plant Biol200818173378No
369834821160.768.522.8Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Juri Rappsilber, Matthias Mann, Yasushi IshihamaNat Protoc200717703201Yes
369923211160.550.125.1Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
370023211160.556.728.4Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
370123201160.061.230.6The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
370211601160.054.754.7The expanding regulatory mechanisms and cellular functions of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol202032366901No
370323181159.058.929.4Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
370411591159.021.221.2The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
370511591159.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VAGUEAm J Clin Nutr195613282851Yes
370611591159.033.733.7Graves' ophthalmopathy. Rebecca S BahnN Engl J Med201020181974No
370723181159.0120.460.2Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. Amy J H Kind, William R BuckinghamN Engl J Med201829949490Yes
370823171158.5131.665.8Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W BUTCHER, E W SUTHERLANDJ Biol Chem196213875173Yes
370911581158.037.437.4Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
371011581158.021.921.9Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
371123161158.055.727.9An improved general amino acid replacement matrix. Si Quang Le, Olivier GascuelMol Biol Evol200818367465Yes
371269461157.7178.129.7Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
371323141157.070.135.0Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
371411571157.028.128.1Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
371511571157.020.920.9Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
371611571157.032.032.0Cellular and molecular mechanisms of renal fibrosis. Youhua LiuNat Rev Nephrol201122009250No
371734701156.772.824.3A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
371823131156.549.124.6Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
371957821156.4164.132.8Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G AltmanPLoS Biol201020613859No
372034691156.383.727.9High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
3721185001156.2679.442.5SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A PevznerJ Comput Biol201222506599Yes
372211561156.019.219.2Evolution and tinkering. F JacobScience1977860134Yes
372311561156.030.930.9Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
372411561156.024.324.3RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
372511561156.033.533.5Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
372611561156.041.341.3Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
372723121156.050.625.3Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
372823121156.057.328.6Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NunezNat Rev Immunol201021088683No
372923111155.566.833.4Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
373023101155.076.938.5Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudasN Engl J Med19921307234Yes
373111551155.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VANEBr J Pharmacol Chemother195713460242Yes
373223091154.545.922.9Fcgamma receptors as regulators of immune responses. Falk Nimmerjahn, Jeffrey V RavetchNat Rev Immunol200818064051No
373346171154.2107.526.9C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
373411541154.021.921.9Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
373511541154.024.524.5Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
373611541154.027.627.6Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
373769211153.5174.129.0The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
373823071153.550.125.1Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Sharon R Browning, Brian L BrowningAm J Hum Genet200717924348Yes
3739126881153.5415.937.8A global reference for human genetic variation. , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R AbecasisNature201526432245Yes
374023061153.046.023.0A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
374123061153.053.226.6Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
374223061153.060.430.2Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
374323051152.556.428.2The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Laetitia Prut, Catherine BelzungEur J Pharmacol200312600700No
374434571152.3100.933.6Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
374511521152.022.922.9Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
374611521152.030.430.4A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
374711521152.033.233.2Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
374811521152.00.00.0A new microscopic principle. D GABORNature194818860291Yes
374923031151.548.524.2Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
375011511151.032.432.4Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
375111511151.023.923.9Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
375223021151.045.122.6Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
375323021151.085.542.8Epidemiology of adult fractures: A review. Charles M Court-Brown, Ben CaesarInjury200616814787No
375446011150.2173.443.4The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. L B Krupp, N G LaRocca, J Muir-Nash, A D SteinbergArch Neurol19892803071Yes
375523001150.046.723.4Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
375611501150.023.223.2Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
375711501150.021.821.8Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
375811501150.020.420.4Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
375911501150.020.220.2The development of neural stem cells. S TempleNature200111689956No
376011491149.044.944.9Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
376111491149.032.532.5Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
376211491149.042.142.1View through a window may influence recovery from surgery. R S UlrichScience19846143402Yes
376311491149.032.032.0DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
376411491149.023.823.8Stem cells in the central nervous system. R McKayScience19979082987No
376534471149.087.629.2Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
376611491149.028.528.5Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
376711491149.027.027.0Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
376822981149.056.828.4Monocyte recruitment during infection and inflammation. Chao Shi, Eric G PamerNat Rev Immunol201121984070No
376922971148.544.522.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
377057421148.4183.036.6A simulation study of the number of events per variable in logistic regression analysis. P Peduzzi, J Concato, E Kemper, T R Holford, A R FeinsteinJ Clin Epidemiol19968970487Yes
377111481148.034.334.3Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
377211481148.026.126.1Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
377322961148.072.936.5Positive psychology. An introduction. M E Seligman, M CsikszentmihalyiAm Psychol200011392865Yes
377422961148.041.120.6AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
377511481148.027.027.0Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
377645901147.5145.836.5The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
377722951147.586.943.5Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Marta Kutas, Kara D FedermeierAnnu Rev Psychol201120809790No
377834421147.3134.945.0Rheumatoid arthritis. Josef S Smolen, Daniel Aletaha, Iain B McInnesLancet201627156434No
377911471147.021.521.5Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
378011471147.021.721.7Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
378111471147.031.331.3Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
378211471147.024.224.2Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
378311471147.025.125.1What is principal component analysis? Markus RingnerNat Biotechnol200818327243Yes
378411471147.032.332.3Targeting the DNA Damage Response in Cancer. Mark J O'ConnorMol Cell201526590714No
378545861146.5109.427.4Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
378622921146.059.229.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
378711461146.033.033.0Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
378822921146.051.325.6Efficient behavior of small-world networks. V Latora, M MarchioriPhys Rev Lett200111690461Yes
378945841146.034.08.5The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLMELancet196313990765Yes
379011461146.028.828.8Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
379111461146.024.024.0Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
379234381146.076.625.5STATs in cancer inflammation and immunity: a leading role for STAT3. Hua Yu, Drew Pardoll, Richard JoveNat Rev Cancer200919851315No
379368741145.7186.131.0Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
379411451145.044.044.0Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
379511451145.037.837.8A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
379611451145.036.636.6Subjective well-being. The science of happiness and a proposal for a national index. E DienerAm Psychol200011392863Yes
379711451145.039.539.5Development of the practice environment scale of the Nursing Work Index. Eileen T LakeRes Nurs Health200212015780Yes
379811451145.029.429.4Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
379922901145.00.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C TRUELOVE, L J WITTSBr Med J195513260656Yes
380034351145.081.127.0Pathogenic Escherichia coli. James B Kaper, James P Nataro, Harry L MobleyNat Rev Microbiol200415040260No
380122901145.063.531.8Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
380222891144.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H USSING, K ZERAHNActa Physiol Scand195114868510Yes
380322891144.547.323.6Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Javier A Menendez, Ruth LupuNat Rev Cancer200717882277No
380434321144.090.930.3Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
380511441144.040.540.5Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
380611441144.043.843.8Reference methods for the assessment of physical characteristics of meat. K O HonikelMeat Sci199822060626Yes
380722871143.545.222.6A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
380811431143.043.643.6Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
380911431143.028.528.5Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
381011431143.031.931.9An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
381111431143.026.126.1BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
381211431143.031.231.2Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. A E BlackInt J Obes Relat Metab Disord200011033980Yes
381311431143.034.234.2Recommended effect size statistics for repeated measures designs. Roger BakemanBehav Res Methods200516405133Yes
381457141142.8196.039.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Open Med200921603045Yes
381534271142.3111.137.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
381622841142.091.445.7The aggression questionnaire. A H Buss, M PerryJ Pers Soc Psychol19921403624Yes
381711421142.033.833.8Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
381811421142.017.017.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EGEBERGThromb Diath Haemorrh196514347873Yes
381911421142.043.343.3A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
382022831141.563.031.5ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
382111411141.026.526.5Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
382234231141.0116.438.8The weirdest people in the world? Joseph Henrich, Steven J Heine, Ara NorenzayanBehav Brain Sci201020550733Yes
382311411141.041.441.4Surface-enhanced Raman spectroscopy: concepts and chemical applications. Sebastian SchluckerAngew Chem Int Ed Engl201424711218Yes
382411401140.034.434.4Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
382522801140.088.144.0Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
382611401140.020.520.5Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
382711401140.067.867.8Diffusion-in-gel methods for immunological analysis. II. O OUCHTERLONYProg Allergy196214482809Yes
382811401140.00.00.0The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. C D MurrayProc Natl Acad Sci U S A192616576980Yes
382911401140.044.644.6Root canal irrigants. Matthias ZehnderJ Endod200616631834No
383011401140.022.822.8Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
383111401140.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HOTCHKISSArch Biochem194818921848Yes
3832205041139.1485.827.0PHENIX: a comprehensive Python-based system for macromolecular structure solution. Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H ZwartActa Crystallogr D Biol Crystallogr201020124702Yes
383322781139.072.336.1Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
383411391139.023.623.6Complement. Second of two parts. M J WalportN Engl J Med200111297706No
383511391139.028.928.9Electrogenerated chemiluminescence and its biorelated applications. Wujian MiaoChem Rev200818505298No
383611391139.031.931.9Conceptual synthesis in community ecology. Mark VellendQ Rev Biol201020565040No
383722771138.585.242.6Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
383822771138.564.432.2Extended-spectrum beta-lactamases: a clinical update. David L Paterson, Robert A BonomoClin Microbiol Rev200516223952No
383934151138.3114.338.1The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Stefka Tyanova, Tikira Temu, Juergen CoxNat Protoc201627809316Yes
384011381138.025.925.9Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
384111381138.016.316.3Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PENNINGTONBiochem J196113734134Yes
384279611137.3135.619.4The human genome browser at UCSC. W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David HausslerGenome Res200212045153Yes
384334121137.3158.552.8The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Karen V Swanson, Meng Deng, Jenny P-Y TingNat Rev Immunol201931036962No
384445491137.297.524.4Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled ClaytonCurr Protoc Cell Biol200618228490Yes
384522741137.059.329.6Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassagueJ Biol Chem19863456347Yes
384611371137.040.040.0Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
384711371137.029.629.6Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
384811371137.025.925.9Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
384911371137.031.931.9Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
385022741137.055.527.8Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
385111371137.023.923.9Pyramidal neurons: dendritic structure and synaptic integration. Nelson SprustonNat Rev Neurosci200818270515No
385211371137.038.838.8Microbial life in the phyllosphere. Julia A VorholtNat Rev Microbiol201223154261No
385356831136.6150.130.0A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo PandolfiCell201121802130Yes
385445461136.5103.825.9SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
385522731136.5136.868.4Modified reagents for determination of urea and ammonia. A L CHANEY, E P MARBACHClin Chem196213878063Yes
385611361136.027.627.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
385711361136.024.924.9Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
385822721136.058.029.0Cu-catalyzed azide-alkyne cycloaddition. Morten Meldal, Christian Wenzel TornoeChem Rev200818698735No
385922721136.074.137.0Glycosylation in cancer: mechanisms and clinical implications. Salome S Pinho, Celso A ReisNat Rev Cancer201526289314No
386011351135.081.281.2Fibula free flap: a new method of mandible reconstruction. D A HidalgoPlast Reconstr Surg19892734406Yes
386111351135.018.518.5The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
386211351135.026.926.9Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
386311351135.020.920.9Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
386411351135.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
386511351135.00.00.0pA, a new scale for the measurement of drug antagonism. H O SCHILDBr J Pharmacol Chemother194720258355Yes
386611351135.059.659.6Cisplatin: The first metal based anticancer drug. Sumit GhoshBioorg Chem201931003078No
386722691134.587.944.0Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
386811341134.034.634.6Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
386934021134.093.131.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
387011341134.027.027.0The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. G HardinScience19685699198Yes
387122681134.041.020.5Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
387211341134.037.837.8Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Murray B IsmanAnnu Rev Entomol200616332203No
387322671133.5101.951.0Neurobiology of addiction: a neurocircuitry analysis. George F Koob, Nora D VolkowLancet Psychiatry201627475769No
387422671133.5113.356.6Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Laura M Doyle, Michael Zhuo WangCells201931311206No
387511331133.027.227.2The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
387611331133.025.725.7Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WurthnerChem Commun (Camb)200415263926Yes
387722651132.585.042.5Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
387833971132.364.421.5Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
387911321132.034.534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
388011321132.045.145.1Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Hannah R SnyderPsychol Bull201322642228No
388111321132.039.339.3T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. Shane CrottyImmunity201931117010No
388222631131.553.626.8T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
388322631131.570.335.1Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
388422631131.555.927.9A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
388511311131.069.369.3Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
388611311131.033.233.2Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
388722621131.052.326.1A note on quantifying follow-up in studies of failure time. M Schemper, T L SmithControl Clin Trials19968889347Yes
388811311131.027.427.4Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
388911311131.023.823.8The action potential in mammalian central neurons. Bruce P BeanNat Rev Neurosci200717514198No
389056531130.6199.940.0A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
389122611130.599.149.5Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
389222611130.552.926.4Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkBioinformatics200717050570Yes
389311301130.023.523.5Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
389411301130.056.356.3The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
389511301130.020.220.2Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
389611301130.042.642.6On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
389711301130.037.537.5A measure of anxiety symptoms among children. S H SpenceBehav Res Ther19989648330Yes
389811301130.022.522.5Alpha-synuclein and neurodegenerative diseases. M GoedertNat Rev Neurosci200111433374No
389911301130.027.027.0Omega-3 fatty acids in inflammation and autoimmune diseases. Artemis P SimopoulosJ Am Coll Nutr200212480795No
390011301130.00.00.0Motivation reconsidered: the concept of competence. R W WHITEPsychol Rev195913844397Yes
390111301130.00.00.0The stereotaxic method and radiosurgery of the brain. L LEKSELLActa Chir Scand195114914373Yes
390211301130.026.626.6Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
390333891129.7118.139.4IL-6 in inflammation, immunity, and disease. Toshio Tanaka, Masashi Narazaki, Tadamitsu KishimotoCold Spring Harb Perspect Biol201425190079No
390422591129.565.032.5Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. R J Ginsberg, L V RubinsteinAnn Thorac Surg19957677489Yes
390511291129.039.839.8Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
390611291129.028.628.6Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
390722581129.045.122.6RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
390811291129.028.528.5Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
390911291129.025.125.1Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
391011291129.031.231.2Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
391111291129.023.023.0The mitochondrial genome: structure, transcription, translation and replication. J W TaanmanBiochim Biophys Acta199910076021No
391211291129.035.735.7Biomedical photoacoustic imaging. Paul BeardInterface Focus201122866233Yes
391311291129.043.243.2Epithelial Mesenchymal Transition in Tumor Metastasis. Vivek MittalAnnu Rev Pathol201829414248No
391433851128.380.226.7In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Chun-Chi Liang, Ann Y Park, Jun-Lin GuanNat Protoc200717406593Yes
391511281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B STAVITSKYJ Immunol195413163409Yes
391633841128.072.524.2Mitochondria, oxidants, and aging. Robert S Balaban, Shino Nemoto, Toren FinkelCell200515734681No
391711281128.024.124.1The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
391811281128.032.032.0The social brain in adolescence. Sarah-Jayne BlakemoreNat Rev Neurosci200818354399No
391922551127.536.418.2Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
392011271127.027.927.9Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
392111271127.032.932.9Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
392211271127.026.926.9The role of acetylcholine in learning and memory. Michael E HasselmoCurr Opin Neurobiol200617011181No
392322541127.053.926.9The neural basis of decision making. Joshua I Gold, Michael N ShadlenAnnu Rev Neurosci200717600525No
392433811127.0122.740.9Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Michael A Postow, Robert Sidlow, Matthew D HellmannN Engl J Med201829320654No
392511261126.021.821.8Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
392611261126.020.320.3Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
392711261126.024.524.5Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
392811261126.019.119.15-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Judith K ChristmanOncogene200212154409No
392911251125.049.449.4Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
393011251125.026.626.6Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
393111251125.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DEESEJ Exp Psychol195913664879Yes
393222491124.548.724.4Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
393311241124.027.827.8The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
393411241124.040.740.7An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. F G HappeJ Autism Dev Disord19948040158Yes
393511241124.025.125.1Mucins in cancer: function, prognosis and therapy. Donald W KufeNat Rev Cancer200919935676No
393644961124.0198.849.7Random effects structure for confirmatory hypothesis testing: Keep it maximal. Dale J Barr, Roger Levy, Christoph Scheepers, Harry J TilyJ Mem Lang201324403724Yes
393711231123.041.441.4Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
393811231123.033.033.0Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
393911231123.021.221.2Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
394011231123.030.130.1Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
394144891122.2115.428.9Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
394211221122.029.629.6The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
394311221122.023.223.2ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
394411221122.024.024.0New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
394511221122.018.518.5Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
394611221122.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B REXEDJ Comp Neurol195413163236Yes
394733651121.7119.239.7Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
394822431121.595.147.5Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
394922431121.562.631.3Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
395022431121.564.632.3Genome-wide efficient mixed-model analysis for association studies. Xiang Zhou, Matthew StephensNat Genet201222706312Yes
395122431121.595.347.6Network analysis: an integrative approach to the structure of psychopathology. Denny Borsboom, Angelique O J CramerAnnu Rev Clin Psychol201323537483No
395222431121.580.440.2Ferroptosis: Death by Lipid Peroxidation. Wan Seok Yang, Brent R StockwellTrends Cell Biol201626653790No
395311211121.026.826.8Hybridization as an invasion of the genome. James MalletTrends Ecol Evol200516701374Yes
395444821120.584.421.1DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
395511201120.011.511.5Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. J J HopfieldProc Natl Acad Sci U S A19744530290Yes
395611201120.035.635.6Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
395711201120.023.023.0Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
395822401120.052.026.0The oxytocin receptor system: structure, function, and regulation. G Gimpl, F FahrenholzPhysiol Rev200111274341No
395911201120.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EASTERBROOKPsychol Rev195913658305Yes
396011201120.024.724.7The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
396111201120.024.824.8Pathogenesis of atherosclerosis. Erling FalkJ Am Coll Cardiol200616631513Yes
396211201120.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
396311201120.026.026.0Ab-initio simulations of materials using VASP: Density-functional theory and beyond. Jurgen HafnerJ Comput Chem200818623101Yes
396411201120.027.127.1Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Richard M CawthonNucleic Acids Res200919129229Yes
396511191119.055.655.6The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
396611191119.037.137.1Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
396711191119.025.325.3P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
396811191119.033.433.4The enteric nervous system and neurogastroenterology. John B FurnessNat Rev Gastroenterol Hepatol201222392290No
396911191119.045.745.7How Many Subjects Does It Take To Do A Regression Analysis. S B GreenMultivariate Behav Res199126776715Yes
397022361118.054.327.1Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
397111181118.036.536.5Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
397211181118.028.228.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
397322361118.026.513.2Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P GOLD, S O FREEDMANJ Exp Med196514270243Yes
397411181118.025.825.8The emotional brain, fear, and the amygdala. Joseph LeDouxCell Mol Neurobiol200314514027No
397511181118.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SPERRYJ Comp Physiol Psychol195014794830Yes
3976111791117.9393.539.4The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherPLoS Med200919621070No
397722351117.563.331.6Neural regulation of endocrine and autonomic stress responses. Yvonne M Ulrich-Lai, James P HermanNat Rev Neurosci200919469025No
397811171117.030.530.5Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
397911171117.036.836.8Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
398011171117.033.833.8Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
398122341117.046.623.3InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
398211171117.030.030.0Innate immunity of fish (overview). Bergljot MagnadottirFish Shellfish Immunol200615950491No
398311171117.020.620.6mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
398422331116.565.832.9A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
398522331116.532.416.2Microdroplet Assay Of Human Serum Cytotoxins. P I TERASAKI, J D MCCLELLANDNature196414248725Yes
398644661116.5140.535.1Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
398711161116.036.336.3Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
398811161116.027.027.0Biological effects of resveratrol. L FremontLife Sci200010680575No
398911161116.022.522.5The muscular dystrophies. Alan E H EmeryLancet200211879882No
399022321116.079.239.6Perceived discrimination and health: a meta-analytic review. Elizabeth A Pascoe, Laura Smart RichmanPsychol Bull200919586161Yes
399111161116.030.030.0Voltage-gated calcium channels. William A CatterallCold Spring Harb Perspect Biol201121746798No
399222311115.552.526.2Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie Beral, Lancet200312927427Yes
399322311115.580.440.2The blood-brain barrier. Richard Daneman, Alexandre PratCold Spring Harb Perspect Biol201525561720No
399411151115.013.313.3Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
399511151115.029.529.5Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
399611151115.021.621.6Automated NMR structure calculation with CYANA. Peter GuntertMethods Mol Biol200415318003Yes
399722301115.058.529.2DNA methylation: roles in mammalian development. Zachary D Smith, Alexander MeissnerNat Rev Genet201323400093No
399822281114.044.122.1In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KarreImmunol Today19902201309No
399911141114.025.725.7NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Weihai YingAntioxid Redox Signal200818020963No
400022271113.588.144.0Global estimates of visual impairment: 2010. Donatella Pascolini, Silvio Paolo MariottiBr J Ophthalmol201222133988Yes
400111131113.028.028.0Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
400222261113.0108.554.2Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
400322261113.069.534.8Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
400411131113.032.532.5Spontaneous dissection of the carotid and vertebral arteries. W I SchievinkN Engl J Med200111259724No
400522261113.046.523.2Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. P J Roberts, C J DerOncogene200717496923No
400622261113.053.426.7Inflammatory bowel disease. Clara Abraham, Judy H ChoN Engl J Med200919923578No
400722261113.0113.856.9Cytokine Storm. David C Fajgenbaum, Carl H JuneN Engl J Med202033264547No
400822241112.045.722.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
400911121112.031.631.6Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
4010144561112.0379.129.2The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , JAMA200312748199No
401111121112.028.128.1Descending pathways in motor control. Roger N LemonAnnu Rev Neurosci200818558853No
401244481112.0113.628.4REVIGO summarizes and visualizes long lists of gene ontology terms. Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav SmucPLoS One201121789182Yes
401344471111.8102.325.6The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
401433351111.7133.944.6A new method for detecting anaerobic threshold by gas exchange. W L Beaver, K Wasserman, B J WhippJ Appl Physiol (1985)19863087938Yes
401522231111.552.426.2The NF-kappaB family of transcription factors and its regulation. Andrea Oeckinghaus, Sankar GhoshCold Spring Harb Perspect Biol200920066092No
401611111111.023.223.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
401711111111.021.721.7Cytokine receptor signalling. J N IhleNature19957566171No
401811111111.025.525.5Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
401922211110.553.726.9The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
402022211110.561.330.6Flexible regression models with cubic splines. S Durrleman, R SimonStat Med19892657958Yes
402144411110.2113.128.3A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
402211101110.061.861.8The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
402311101110.022.122.1Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
402422201110.077.438.7Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
402511101110.022.422.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
402611101110.020.420.4Cytokines in cancer pathogenesis and cancer therapy. Glenn DranoffNat Rev Cancer200414708024No
402722201110.079.139.5NAFLD: a multisystem disease. Christopher D Byrne, Giovanni TargherJ Hepatol201525920090No
402833281109.3108.736.2Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
402911091109.039.139.1Perceptual selectivity for color and form. J TheeuwesPercept Psychophys19921620571No
403011091109.041.541.5Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
403144351108.8108.127.0An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
403222171108.554.327.1Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. D Rice, S BaroneEnviron Health Perspect200010852851No
403322171108.552.426.2CpG islands and the regulation of transcription. Aimee M Deaton, Adrian BirdGenes Dev201121576262No
403433251108.3109.636.5A new rating scale for Alzheimer's disease. W G Rosen, R C Mohs, K L DavisAm J Psychiatry19846496779Yes
403544331108.2159.439.9Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
403611081108.026.026.0A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
403722161108.056.328.1Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. L Pellerin, P J MagistrettiProc Natl Acad Sci U S A19947938003Yes
403811081108.022.922.9The molecular biology of coronaviruses. Paul S MastersAdv Virus Res200616877062No
403911081108.042.942.9Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. Peter J BarnesJ Allergy Clin Immunol201627373322No
404066471107.8148.824.8Alpha-synuclein in Lewy bodies. M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M GoedertNature19979278044Yes
404144301107.5118.129.5A role for mitochondria in NLRP3 inflammasome activation. Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg TschoppNature201121124315Yes
404222151107.5159.679.8TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Jan P Meier-Kolthoff, Markus GokerNat Commun201931097708Yes
404311071107.013.813.8The evolutionary advantage of recombination. J FelsensteinGenetics19744448362Yes
404411071107.032.032.0Image matching as a diffusion process: an analogy with Maxwell's demons. J P ThirionMed Image Anal19989873902Yes
404511071107.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TEALEBiochim Biophys Acta195913837237Yes
404611071107.034.834.8Vitamin D status: measurement, interpretation, and clinical application. Michael F HolickAnn Epidemiol200918329892No
404711071107.035.735.7Targeting metastasis. Patricia S SteegNat Rev Cancer201627009393No
404811071107.057.857.8COVID-19: immunopathology and its implications for therapy. Xuetao CaoNat Rev Immunol202032273594Yes
404922131106.564.832.4Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
405022131106.548.924.4How to interpret LC3 immunoblotting. Noboru Mizushima, Tamotsu YoshimoriAutophagy200717611390No
405122131106.553.626.8Recent developments in the MAFFT multiple sequence alignment program. Kazutaka Katoh, Hiroyuki TohBrief Bioinform200818372315Yes
405255311106.2115.123.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
405344251106.2152.838.2Development of recommendations for SEMG sensors and sensor placement procedures. H J Hermens, B Freriks, C Disselhorst-Klug, G RauJ Electromyogr Kinesiol200011018445Yes
405422121106.045.522.8An energy budget for signaling in the grey matter of the brain. D Attwell, S B LaughlinJ Cereb Blood Flow Metab200111598490No
405511061106.026.126.1Soil carbon sequestration impacts on global climate change and food security. R LalScience200415192216Yes
405622121106.060.030.0The spread of obesity in a large social network over 32 years. Nicholas A Christakis, James H FowlerN Engl J Med200717652652Yes
405744221105.5149.037.2Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
405822111105.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H COONS, M H KAPLANJ Exp Med195015395569Yes
405911051105.00.00.0Asymptomatic infections of the urinary tract. E H KASSTrans Assoc Am Physicians195613380946Yes
406022091104.548.624.3Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
406111041104.029.829.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
406211041104.021.021.0The evolutionary significance of cis-regulatory mutations. Gregory A WrayNat Rev Genet200717304246No
406322071103.571.635.8Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
406411031103.022.022.0Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
406511031103.021.621.6Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
406622061103.049.324.6Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
406711031103.021.521.5Unfolding the role of protein misfolding in neurodegenerative diseases. Claudio SotoNat Rev Neurosci200312511861No
406833091103.091.330.4Foreign body reaction to biomaterials. James M Anderson, Analiz Rodriguez, David T ChangSemin Immunol200818162407No
406911031103.030.930.9Lanthanide-based luminescent hybrid materials. Koen BinnemansChem Rev200919650663Yes
407011031103.036.136.1Supramolecular binding thermodynamics by dispersion-corrected density functional theory. Stefan GrimmeChemistry201222782805Yes
407133091103.0188.862.9Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
407222051102.545.122.6p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
407322051102.538.219.1Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
407466141102.3164.327.4Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
407511021102.023.723.7A cortical-hippocampal system for declarative memory. H EichenbaumNat Rev Neurosci200011252767No
407611021102.022.522.5Large-scale recording of neuronal ensembles. Gyorgy BuzsakiNat Neurosci200415114356No
407711021102.041.141.1Fiber and prebiotics: mechanisms and health benefits. Joanne SlavinNutrients201323609775No
407822031101.565.432.72,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
407922031101.563.331.6The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
408011011101.026.926.9Avidin. N M GreenAdv Protein Chem1975237414Yes
408111011101.045.145.1Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
408211011101.041.941.9The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
408322021101.082.141.0The structure of psychological well-being revisited. C D Ryff, C L KeyesJ Pers Soc Psychol19957473027Yes
408411011101.033.733.7The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
408511011101.024.124.1The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
408611011101.031.131.1Cytochrome p450 and chemical toxicology. F Peter GuengerichChem Res Toxicol200818052394No
408722011100.564.432.2Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
408811001100.020.620.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
408911001100.022.922.9Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
409011001100.031.431.4The broaden-and-build theory of positive emotions. Barbara L FredricksonPhilos Trans R Soc Lond B Biol Sci200415347528No
409121991099.50.00.0Micromethod for the direct determination of serum triglycerides. E VAN HANDEL, D B ZILVERSMITJ Lab Clin Med195713439279Yes
409210991099.023.823.8Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
409310991099.032.232.2The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. R CharonJAMA200111597295Yes
409410991099.024.624.6The primate basal ganglia: parallel and integrative networks. Suzanne N HaberJ Chem Neuroanat200314729134No
409521981099.054.527.2A general purpose model for the condensed phases of water: TIP4P/2005. J L F Abascal, C VegaJ Chem Phys200516392929Yes
409610991099.023.023.0The self-tuning neuron: synaptic scaling of excitatory synapses. Gina G TurrigianoCell200818984155No
409710991099.023.623.6Cells of origin in cancer. Jane E VisvaderNature201121248838No
409821981099.065.732.9The human microbiome: at the interface of health and disease. Ilseung Cho, Martin J BlaserNat Rev Genet201222411464No
409910991099.037.637.6Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. Gyorgy BuzsakiHippocampus201526135716No
410010991099.068.068.0Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. Cheng-Hsien LiBehav Res Methods201626174714Yes
410110981098.032.432.4Comparing evolvability and variability of quantitative traits. D HouleGenetics19921732160Yes
410210981098.019.019.0Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
410321961098.034.817.4Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
410410981098.034.934.9Mental illness and/or mental health? Investigating axioms of the complete state model of health. Corey L M KeyesJ Consult Clin Psychol200515982151Yes
410510981098.025.925.9Trypan blue exclusion test of cell viability. W StroberCurr Protoc Immunol200118432654Yes
410621961098.048.924.4Mechanisms of endocytosis. Gary J Doherty, Harvey T McMahonAnnu Rev Biochem200919317650No
410710981098.047.847.8Fibromyalgia: a clinical review. Daniel J ClauwJAMA201424737367No
410821951097.558.029.0The cerebellar cognitive affective syndrome. J D Schmahmann, J C ShermanBrain19989577385Yes
410910971097.018.818.8Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
411010971097.020.620.6Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
411110971097.025.525.5Area deprivation and widening inequalities in US mortality, 1969-1998. Gopal K SinghAm J Public Health200312835199Yes
411210971097.027.227.2Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Jill E ClarridgeClin Microbiol Rev200415489351No
411321941097.069.334.6Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Lance W Peterson, David ArtisNat Rev Immunol201424566914No
411410971097.034.334.3Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
411576781096.9680.197.2The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James RubinLancet202032112714No
411621931096.589.444.7Emotional processing of fear: exposure to corrective information. E B Foa, M J KozakPsychol Bull19862871574Yes
411721931096.547.523.8p21 in cancer: intricate networks and multiple activities. Tarek Abbas, Anindya DuttaNat Rev Cancer200919440234No
411843851096.2108.027.0Wound repair and regeneration. Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T LongakerNature200818480812No
411910961096.037.437.4A theory of visual attention. C BundesenPsychol Rev19902247540Yes
412021921096.068.134.0Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
412110961096.025.225.2Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
412210961096.020.120.1Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
412310961096.020.420.4The immune response of Drosophila. Jules A HoffmannNature200314603309No
412410961096.027.627.6Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Paul H YanceyJ Exp Biol200516043587No
412510961096.018.218.2The concept of synthetic lethality in the context of anticancer therapy. William G KaelinNat Rev Cancer200516110319No
412610961096.026.526.5Sleep-dependent memory consolidation. Robert StickgoldNature200516251952No
412743831095.8132.533.1Causal analysis approaches in Ingenuity Pathway Analysis. Andreas Kramer, Jeff Green, Jack Pollard, Stuart TugendreichBioinformatics201424336805Yes
412821911095.564.032.0Stool form scale as a useful guide to intestinal transit time. S J Lewis, K W HeatonScand J Gastroenterol19979299672Yes
412910951095.024.824.8Marine viruses and their biogeochemical and ecological effects. J A FuhrmanNature199910376593No
413010951095.011.611.6The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CRONEActa Physiol Scand196314078649Yes
413110951095.023.723.7Immunosuppressive drugs for kidney transplantation. Philip F HalloranN Engl J Med200415616206No
413210951095.029.229.2Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No

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