Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 4083 papers with ECcit ≥ 1077.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 61, September 2025
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 225850 | 225850.0 | 4688.0 | 4688.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 179425 | 179425.0 | 7085.7 | 7085.7 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 288031 | 72007.8 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 135473 | 67736.5 | 3321.1 | 1660.5 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 46499 | 46499.0 | 1378.0 | 1378.0 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 38363 | 38363.0 | 1234.0 | 1234.0 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64703 | 32351.5 | 1931.6 | 965.8 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30251 | 30251.0 | 823.4 | 823.4 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 29206 | 29206.0 | 678.2 | 678.2 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 10 | 29167 | 29167.0 | 918.2 | 918.2 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 28827 | 28827.0 | 624.3 | 624.3 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | False |
| 12 | 27312 | 27312.0 | 697.2 | 697.2 | A rating scale for depression. | M HAMILTON | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 26097 | 26097.0 | 591.2 | 591.2 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 25389 | 25389.0 | 791.1 | 791.1 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 46739 | 23369.5 | 1386.9 | 693.5 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | False |
| 16 | 69285 | 23095.0 | 2529.5 | 843.2 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 17 | 22602 | 22602.0 | 616.8 | 616.8 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 18 | 66311 | 22103.7 | 1642.3 | 547.4 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 19 | 21653 | 21653.0 | 733.8 | 733.8 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 41585 | 20792.5 | 1283.1 | 641.5 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 21 | 20428 | 20428.0 | 204.2 | 204.2 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J Cell Biol | 1963 | 13986422 | Yes |
| 22 | 20301 | 20301.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 23 | 59054 | 19684.7 | 2066.4 | 688.8 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 24 | 39265 | 19632.5 | 1606.4 | 803.2 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 25 | 19260 | 19260.0 | 759.9 | 759.9 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 26 | 37783 | 18891.5 | 1761.9 | 881.0 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 27 | 36870 | 18435.0 | 1111.6 | 555.8 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 28 | 55171 | 18390.3 | 1605.6 | 535.2 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 29 | 18238 | 18238.0 | 672.3 | 672.3 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 30 | 18124 | 18124.0 | 740.9 | 740.9 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 31 | 53614 | 17871.3 | 2029.4 | 676.5 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 32 | 34591 | 17295.5 | 847.3 | 423.6 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 33 | 17272 | 17272.0 | 427.8 | 427.8 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | False |
| 34 | 16768 | 16768.0 | 283.1 | 283.1 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J DAVIS | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 35 | 33493 | 16746.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 36 | 16513 | 16513.0 | 762.9 | 762.9 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 37 | 32844 | 16422.0 | 1297.9 | 649.0 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 38 | 16222 | 16222.0 | 449.7 | 449.7 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 39 | 16046 | 16046.0 | 389.1 | 389.1 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | False |
| 40 | 15937 | 15937.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem J | 1956 | 13293190 | Yes |
| 41 | 31668 | 15834.0 | 1177.7 | 588.9 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 42 | 15731 | 15731.0 | 605.7 | 605.7 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 43 | 46203 | 15401.0 | 1311.1 | 437.0 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 44 | 30756 | 15378.0 | 829.2 | 414.6 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 45 | 43094 | 14364.7 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J Biol Chem | 1957 | 13428781 | Yes |
| 46 | 13760 | 13760.0 | 520.4 | 520.4 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 47 | 41124 | 13708.0 | 1498.0 | 499.3 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 48 | 13670 | 13670.0 | 334.6 | 334.6 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 49 | 26987 | 13493.5 | 544.8 | 272.4 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 50 | 67076 | 13415.2 | 1917.2 | 383.4 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 51 | 26611 | 13305.5 | 708.6 | 354.3 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 52 | 13247 | 13247.0 | 601.9 | 601.9 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 53 | 13224 | 13224.0 | 404.4 | 404.4 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 54 | 13197 | 13197.0 | 440.7 | 440.7 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 55 | 26172 | 13086.0 | 1058.1 | 529.0 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 56 | 13078 | 13078.0 | 391.2 | 391.2 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 57 | 38964 | 12988.0 | 1352.9 | 451.0 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 58 | 25886 | 12943.0 | 934.3 | 467.1 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 59 | 12713 | 12713.0 | 147.1 | 147.1 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 60 | 12657 | 12657.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J Biol Chem | 1959 | 13641241 | Yes |
| 61 | 12394 | 12394.0 | 405.9 | 405.9 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 62 | 24785 | 12392.5 | 527.2 | 263.6 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 63 | 36963 | 12321.0 | 955.4 | 318.5 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 64 | 12081 | 12081.0 | 507.5 | 507.5 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 65 | 36234 | 12078.0 | 1160.0 | 386.7 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | False |
| 66 | 24082 | 12041.0 | 518.2 | 259.1 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 67 | 11914 | 11914.0 | 448.7 | 448.7 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 68 | 45848 | 11462.0 | 1286.2 | 321.6 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | False |
| 69 | 11031 | 11031.0 | 499.8 | 499.8 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 70 | 22059 | 11029.5 | 924.5 | 462.2 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 71 | 10848 | 10848.0 | 276.3 | 276.3 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 72 | 10813 | 10813.0 | 356.0 | 356.0 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 73 | 21557 | 10778.5 | 555.4 | 277.7 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 74 | 10590 | 10590.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 75 | 10372 | 10372.0 | 438.2 | 438.2 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 76 | 10303 | 10303.0 | 201.2 | 201.2 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 77 | 10228 | 10228.0 | 281.9 | 281.9 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | False |
| 78 | 10164 | 10164.0 | 287.6 | 287.6 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 79 | 40284 | 10071.0 | 1461.2 | 365.3 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 80 | 10003 | 10003.0 | 203.2 | 203.2 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 81 | 19814 | 9907.0 | 356.4 | 178.2 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 82 | 39607 | 9901.8 | 1268.7 | 317.2 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 83 | 9752 | 9752.0 | 272.3 | 272.3 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | False |
| 84 | 29195 | 9731.7 | 841.9 | 280.6 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 85 | 19376 | 9688.0 | 495.2 | 247.6 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 86 | 29053 | 9684.3 | 743.2 | 247.7 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 87 | 9683 | 9683.0 | 227.9 | 227.9 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 88 | 19364 | 9682.0 | 496.8 | 248.4 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 89 | 9602 | 9602.0 | 317.1 | 317.1 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | False |
| 90 | 9566 | 9566.0 | 246.9 | 246.9 | Canonical dynamics: Equilibrium phase-space distributions. | WG Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 91 | 9564 | 9564.0 | 242.0 | 242.0 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 92 | 9516 | 9516.0 | 377.1 | 377.1 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 93 | 9496 | 9496.0 | 250.4 | 250.4 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 94 | 18982 | 9491.0 | 390.1 | 195.1 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | False |
| 95 | 18894 | 9447.0 | 557.5 | 278.8 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 96 | 28169 | 9389.7 | 696.0 | 232.0 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 97 | 9315 | 9315.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 98 | 9254 | 9254.0 | 262.6 | 262.6 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 99 | 9200 | 9200.0 | 257.8 | 257.8 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | False |
| 100 | 9200 | 9200.0 | 234.6 | 234.6 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | False |
| 101 | 9155 | 9155.0 | 235.2 | 235.2 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 102 | 18306 | 9153.0 | 391.3 | 195.7 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 103 | 9081 | 9081.0 | 231.9 | 231.9 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | False |
| 104 | 18102 | 9051.0 | 415.9 | 207.9 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 105 | 26969 | 8989.7 | 1348.6 | 449.5 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 106 | 8939 | 8939.0 | 176.7 | 176.7 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 107 | 8825 | 8825.0 | 257.9 | 257.9 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 108 | 8823 | 8823.0 | 183.7 | 183.7 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | False |
| 109 | 8809 | 8809.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M HAMILTON | Br J Med Psychol | 1959 | 13638508 | Yes |
| 110 | 17406 | 8703.0 | 572.0 | 286.0 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 111 | 34500 | 8625.0 | 1108.5 | 277.1 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 112 | 8487 | 8487.0 | 387.5 | 387.5 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 113 | 16865 | 8432.5 | 389.4 | 194.7 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 114 | 25150 | 8383.3 | 745.9 | 248.6 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 115 | 16668 | 8334.0 | 372.1 | 186.1 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 116 | 8199 | 8199.0 | 221.4 | 221.4 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 117 | 8130 | 8130.0 | 195.3 | 195.3 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 118 | 16216 | 8108.0 | 988.9 | 494.4 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 119 | 16116 | 8058.0 | 387.3 | 193.7 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 120 | 8040 | 8040.0 | 195.2 | 195.2 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | False |
| 121 | 7991 | 7991.0 | 335.3 | 335.3 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 122 | 7944 | 7944.0 | 154.9 | 154.9 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | False |
| 123 | 7916 | 7916.0 | 218.1 | 218.1 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 124 | 7887 | 7887.0 | 163.8 | 163.8 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | False |
| 125 | 23640 | 7880.0 | 810.5 | 270.2 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 126 | 7868 | 7868.0 | 245.6 | 245.6 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 127 | 7860 | 7860.0 | 226.3 | 226.3 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 128 | 7848 | 7848.0 | 331.6 | 331.6 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 129 | 7808 | 7808.0 | 254.3 | 254.3 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 130 | 7798 | 7798.0 | 215.2 | 215.2 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | False |
| 131 | 7761 | 7761.0 | 268.6 | 268.6 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 132 | 23279 | 7759.7 | 902.3 | 300.8 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 133 | 7699 | 7699.0 | 218.4 | 218.4 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 134 | 7684 | 7684.0 | 229.1 | 229.1 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 135 | 7678 | 7678.0 | 220.1 | 220.1 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 136 | 15127 | 7563.5 | 414.2 | 207.1 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 137 | 52903 | 7557.6 | 1348.7 | 192.7 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | False |
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| 3623 | 2296 | 1148.0 | 58.3 | 29.1 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | False |
| 3624 | 2295 | 1147.5 | 59.0 | 29.5 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | False |
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| 3632 | 2292 | 1146.0 | 46.6 | 23.3 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3633 | 1146 | 1146.0 | 33.2 | 33.2 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
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| 3638 | 2291 | 1145.5 | 91.3 | 45.6 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jérôme Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | False |
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| 3643 | 1145 | 1145.0 | 43.2 | 43.2 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | False |
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| 3651 | 1143 | 1143.0 | 28.6 | 28.6 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
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| 3705 | 1135 | 1135.0 | 40.2 | 40.2 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | False |
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| 3709 | 2268 | 1134.0 | 72.3 | 36.1 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
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| 3720 | 3401 | 1133.7 | 174.5 | 58.2 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | False |
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| 3722 | 2267 | 1133.5 | 58.6 | 29.3 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | False |
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| 3762 | 1127 | 1127.0 | 20.1 | 20.1 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3763 | 1127 | 1127.0 | 33.1 | 33.1 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | False |
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| 3766 | 2252 | 1126.0 | 53.3 | 26.6 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3767 | 1126 | 1126.0 | 27.9 | 27.9 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | False |
| 3768 | 1126 | 1126.0 | 21.8 | 21.8 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | False |
| 3769 | 2252 | 1126.0 | 135.9 | 68.0 | Modified reagents for determination of urea and ammonia. | A L CHANEY, E P MARBACH | Clin Chem | 1962 | 13878063 | Yes |
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| 3771 | 1126 | 1126.0 | 26.5 | 26.5 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | False |
| 3772 | 1126 | 1126.0 | 24.3 | 24.3 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | False |
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| 3774 | 1125 | 1125.0 | 49.6 | 49.6 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | False |
| 3775 | 1125 | 1125.0 | 34.4 | 34.4 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | False |
| 3776 | 1125 | 1125.0 | 36.1 | 36.1 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
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| 3779 | 1125 | 1125.0 | 25.7 | 25.7 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
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| 3782 | 4497 | 1124.2 | 201.2 | 50.3 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | False |
| 3783 | 1124 | 1124.0 | 18.5 | 18.5 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
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| 3786 | 1124 | 1124.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
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| 3788 | 7862 | 1123.1 | 134.7 | 19.2 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3789 | 1123 | 1123.0 | 41.4 | 41.4 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
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| 3800 | 1121 | 1121.0 | 26.5 | 26.5 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3801 | 1121 | 1121.0 | 29.6 | 29.6 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
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| 3803 | 1121 | 1121.0 | 23.2 | 23.2 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
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| 3805 | 3363 | 1121.0 | 80.1 | 26.7 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | False |
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| 3831 | 2233 | 1116.5 | 76.7 | 38.4 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
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| 3843 | 2228 | 1114.0 | 32.4 | 16.2 | Microdroplet Assay Of Human Serum Cytotoxins. | P I TERASAKI, J D MCCLELLAND | Nature | 1964 | 14248725 | Yes |
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| 3855 | 1112 | 1112.0 | 28.2 | 28.2 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | False |
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| 3862 | 1111 | 1111.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W SPERRY | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
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| 3864 | 1111 | 1111.0 | 20.6 | 20.6 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | False |
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| 3868 | 2220 | 1110.0 | 94.8 | 47.4 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
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| 3879 | 1109 | 1109.0 | 37.1 | 37.1 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | False |
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| 4033 | 2170 | 1085.0 | 62.0 | 31.0 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | False |
| 4034 | 2169 | 1084.5 | 46.7 | 23.4 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | False |
| 4035 | 1084 | 1084.0 | 29.4 | 29.4 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | False |
| 4036 | 1084 | 1084.0 | 23.0 | 23.0 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
| 4037 | 1084 | 1084.0 | 29.5 | 29.5 | Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. | R Bonnet | Antimicrob Agents Chemother | 2004 | 14693512 | False |
| 4038 | 1084 | 1084.0 | 22.3 | 22.3 | Large-scale recording of neuronal ensembles. | György Buzsáki | Nat Neurosci | 2004 | 15114356 | False |
| 4039 | 1084 | 1084.0 | 0.0 | 0.0 | On the Absorption of Fluids from the Connective Tissue Spaces. | E H Starling | J Physiol | 1896 | 16992325 | Yes |
| 4040 | 1083 | 1083.0 | 27.1 | 27.1 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | False |
| 4041 | 1083 | 1083.0 | 23.8 | 23.8 | Immunosuppressive drugs for kidney transplantation. | Philip F Halloran | N Engl J Med | 2004 | 15616206 | False |
| 4042 | 3247 | 1082.3 | 194.3 | 64.8 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 4043 | 2164 | 1082.0 | 101.9 | 51.0 | Development, reliability, and validity of a dissociation scale. | E M Bernstein, F W Putnam | J Nerv Ment Dis | 1986 | 3783140 | Yes |
| 4044 | 1082 | 1082.0 | 24.3 | 24.3 | Pathogenesis of atherosclerosis. | Erling Falk | J Am Coll Cardiol | 2006 | 16631513 | Yes |
| 4045 | 1082 | 1082.0 | 25.6 | 25.6 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4046 | 2164 | 1082.0 | 63.4 | 31.7 | Genome-wide efficient mixed-model analysis for association studies. | Xiang Zhou, Matthew Stephens | Nat Genet | 2012 | 22706312 | Yes |
| 4047 | 2163 | 1081.5 | 45.0 | 22.5 | A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. | S Whelan, N Goldman | Mol Biol Evol | 2001 | 11319253 | Yes |
| 4048 | 5406 | 1081.2 | 139.8 | 28.0 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4049 | 1081 | 1081.0 | 28.6 | 28.6 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 4050 | 1081 | 1081.0 | 18.4 | 18.4 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
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| 4052 | 1080 | 1080.0 | 27.4 | 27.4 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
| 4053 | 1080 | 1080.0 | 29.0 | 29.0 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | False |
| 4054 | 1080 | 1080.0 | 27.1 | 27.1 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
| 4055 | 1080 | 1080.0 | 23.4 | 23.4 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | False |
| 4056 | 1080 | 1080.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
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| 4061 | 3237 | 1079.0 | 81.5 | 27.2 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
| 4062 | 1079 | 1079.0 | 29.6 | 29.6 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
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| 4064 | 3237 | 1079.0 | 76.6 | 25.5 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | False |
| 4065 | 1079 | 1079.0 | 21.9 | 21.9 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | False |
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| 4067 | 1079 | 1079.0 | 27.5 | 27.5 | Descending pathways in motor control. | Roger N Lemon | Annu Rev Neurosci | 2008 | 18558853 | False |
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| 4069 | 1079 | 1079.0 | 38.9 | 38.9 | T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. | Shane Crotty | Immunity | 2019 | 31117010 | False |
| 4070 | 1078 | 1078.0 | 32.9 | 32.9 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
| 4071 | 1078 | 1078.0 | 42.2 | 42.2 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
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| 4073 | 1078 | 1078.0 | 30.5 | 30.5 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
| 4074 | 1078 | 1078.0 | 14.1 | 14.1 | Relative and absolute strength of response as a function of frequency of reinforcement. | R J HERRNSTEIN | J Exp Anal Behav | 1961 | 13713775 | Yes |
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| 4076 | 1078 | 1078.0 | 20.1 | 20.1 | Tetraspanin functions and associated microdomains. | Martin E Hemler | Nat Rev Mol Cell Biol | 2005 | 16314869 | False |
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