Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	226215	226215.0	4709.5	4709.5	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	182776	182776.0	7214.7	7214.7	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	288308	72077.0	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL	J Biol Chem	1951	14907713	Yes
4	140183	70091.5	3424.0	1712.0	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	46740	46740.0	1371.0	1371.0	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	38956	38956.0	1253.6	1253.6	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	64778	32389.0	1930.8	965.4	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30270	30270.0	807.2	807.2	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	29963	29963.0	691.2	691.2	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
10	29671	29671.0	932.9	932.9	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
11	29019	29019.0	623.5	623.5	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
12	27898	27898.0	708.4	708.4	A rating scale for depression.	M HAMILTON	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
13	26554	26554.0	599.8	599.8	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
14	25766	25766.0	805.2	805.2	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
15	24165	24165.0	651.4	651.4	Projector augmented-wave method.	P E Blochl	Phys Rev B Condens Matter	1994	9976227	Yes
16	48256	24128.0	1408.3	704.1	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
17	70495	23498.3	2516.0	838.7	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
18	66449	22149.7	1634.7	544.9	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
19	22128	22128.0	748.4	748.4	Density-functional exchange-energy approximation with correct asymptotic behavior.	A D Becke	Phys Rev A Gen Phys	1988	9900728	Yes
20	66196	22065.3	2278.5	759.5	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
21	42040	21020.0	1296.0	648.0	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
22	20603	20603.0	0.0	0.0	Tissue sulfhydryl groups.	G L ELLMAN	Arch Biochem Biophys	1959	13650640	Yes
23	20493	20493.0	204.2	204.2	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S REYNOLDS	J Cell Biol	1963	13986422	Yes
24	20094	20094.0	776.0	776.0	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
25	40184	20092.0	1620.3	810.1	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
26	39564	19782.0	1174.9	587.5	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
27	58538	19512.7	1685.3	561.8	Generalized Gradient Approximation Made Simple.	J P Perdew, K Burke, M Ernzerhof	Phys Rev Lett	1996	10062328	Yes
28	38067	19033.5	1762.1	881.0	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
29	18545	18545.0	681.3	681.3	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
30	18494	18494.0	754.2	754.2	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
31	36600	18300.0	884.4	442.2	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
32	53643	17881.0	2014.4	671.5	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
33	17488	17488.0	785.0	785.0	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
34	17356	17356.0	427.7	427.7	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
35	33938	16969.0	1332.8	666.4	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
36	16773	16773.0	282.5	282.5	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J DAVIS	Ann N Y Acad Sci	1964	14240539	Yes
37	33533	16766.5	0.0	0.0	A rapid method of total lipid extraction and purification.	E G BLIGH, W J DYER	Can J Biochem Physiol	1959	13671378	Yes
38	32918	16459.0	878.3	439.1	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	G Kresse, J Furthmuller	Phys Rev B Condens Matter	1996	9984901	Yes
39	16375	16375.0	626.1	626.1	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
40	16229	16229.0	441.2	441.2	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
41	16211	16211.0	387.2	387.2	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
42	32402	16201.0	1199.3	599.6	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
43	15943	15943.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K BURTON	Biochem J	1956	13293190	Yes
44	46509	15503.0	1319.4	439.8	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
45	14921	14921.0	554.3	554.3	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
46	44708	14902.7	1596.7	532.2	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
47	43316	14438.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J FOLCH, M LEES, G H SLOANE STANLEY	J Biol Chem	1957	13428781	Yes
48	14151	14151.0	340.5	340.5	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
49	28261	14130.5	1004.3	502.1	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
50	14129	14129.0	465.1	465.1	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
51	27841	13920.5	738.4	369.2	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
52	27654	13827.0	552.5	276.2	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
53	68797	13759.4	1963.7	392.7	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
54	13705	13705.0	615.3	615.3	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
55	26966	13483.0	573.9	286.9	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
56	13450	13450.0	404.4	404.4	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
57	13406	13406.0	550.5	550.5	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
58	13348	13348.0	398.2	398.2	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
59	39937	13312.3	1382.0	460.7	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	C Lee, W Yang, R G Parr	Phys Rev B Condens Matter	1988	9944570	Yes
60	26504	13252.0	1064.1	532.0	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
61	39205	13068.3	1012.5	337.5	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
62	13034	13034.0	151.3	151.3	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
63	38334	12778.0	1209.8	403.3	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
64	12663	12663.0	413.7	413.7	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
65	12658	12658.0	0.0	0.0	Phosphorus assay in column chromatography.	G R BARTLETT	J Biol Chem	1959	13641241	Yes
66	12333	12333.0	460.8	460.8	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
67	47819	11954.8	1332.1	333.0	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
68	23849	11924.5	513.1	256.6	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
69	11911	11911.0	523.8	523.8	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
70	11234	11234.0	281.8	281.8	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
71	22401	11200.5	929.3	464.6	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
72	10859	10859.0	351.9	351.9	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
73	10837	10837.0	0.0	0.0	On the origin of cancer cells.	O WARBURG	Science	1956	13298683	Yes
74	21552	10776.0	554.8	277.4	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
75	31824	10608.0	910.7	303.6	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
76	21189	10594.5	617.9	308.9	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
77	10547	10547.0	441.3	441.3	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
78	10545	10545.0	285.2	285.2	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
79	41649	10412.2	1499.1	374.8	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
80	41601	10400.2	1325.4	331.4	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
81	10321	10321.0	292.6	292.6	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
82	10315	10315.0	196.1	196.1	Improvements in epoxy resin embedding methods.	J H LUFT	J Biophys Biochem Cytol	1961	13764136	Yes
83	30778	10259.3	775.9	258.6	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
84	10137	10137.0	204.4	204.4	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
85	10094	10094.0	235.5	235.5	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
86	20057	10028.5	508.5	254.2	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
87	10027	10027.0	257.7	257.7	Canonical dynamics: Equilibrium phase-space distributions.	W G Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
88	19820	9910.0	354.8	177.4	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
89	9906	9906.0	384.7	384.7	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
90	9874	9874.0	272.7	272.7	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
91	19667	9833.5	446.8	223.4	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
92	19560	9780.0	502.4	251.2	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
93	9669	9669.0	316.9	316.9	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
94	19277	9638.5	395.5	197.8	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
95	9616	9616.0	241.4	241.4	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
96	9597	9597.0	388.4	388.4	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
97	9595	9595.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
98	9555	9555.0	241.2	241.2	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
99	28622	9540.7	697.0	232.3	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
100	9538	9538.0	251.3	251.3	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
101	37463	9365.8	1196.8	299.2	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
102	18663	9331.5	393.6	196.8	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
103	18623	9311.5	427.2	213.6	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
104	9284	9284.0	238.4	238.4	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
105	18514	9257.0	602.4	301.2	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
106	9253	9253.0	260.9	260.9	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
107	9215	9215.0	257.4	257.4	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
108	18421	9210.5	1084.8	542.4	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
109	45859	9171.8	1688.9	337.8	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	PLoS Med	2009	19621072	No
110	27288	9096.0	1318.8	439.6	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
111	9095	9095.0	0.0	0.0	The assessment of anxiety states by rating.	M HAMILTON	Br J Med Psychol	1959	13638508	Yes
112	9094	9094.0	264.7	264.7	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
113	9063	9063.0	231.6	231.6	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
114	9025	9025.0	177.0	177.0	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
115	27014	9004.7	916.7	305.6	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
116	8832	8832.0	182.2	182.2	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
117	26292	8764.0	774.4	258.1	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
118	8733	8733.0	395.2	395.2	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
119	8527	8527.0	352.3	352.3	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
120	17047	8523.5	380.1	190.1	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
121	8361	8361.0	226.4	226.4	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
122	8218	8218.0	198.2	198.2	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	8156	8156.0	279.9	279.9	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
124	16301	8150.5	390.4	195.2	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
125	8143	8143.0	194.4	194.4	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
126	8128	8128.0	251.9	251.9	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
127	16145	8072.5	440.2	220.1	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
128	8045	8045.0	165.2	165.2	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
129	8015	8015.0	155.6	155.6	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
130	7945	7945.0	254.2	254.2	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
131	7938	7938.0	217.8	217.8	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
132	7923	7923.0	257.5	257.5	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	J P Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
133	7887	7887.0	226.2	226.2	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
134	15717	7858.5	412.7	206.3	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
135	7816	7816.0	198.6	198.6	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
136	15630	7815.0	397.9	198.9	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
137	7804	7804.0	215.0	215.0	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
138	7803	7803.0	232.3	232.3	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
139	23407	7802.3	904.8	301.6	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
140	7722	7722.0	219.1	219.1	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
141	7714	7714.0	220.9	220.9	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Boyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
142	15305	7652.5	512.4	256.2	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
143	53370	7624.3	1358.6	194.1	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
144	7413	7413.0	118.5	118.5	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
145	7247	7247.0	0.0	0.0	Index for rating diagnostic tests.	W J YOUDEN	Cancer	1950	15405679	Yes
146	14343	7171.5	774.6	387.3	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
147	7081	7081.0	191.2	191.2	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
148	7056	7056.0	209.1	209.1	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
149	7035	7035.0	116.9	116.9	A Self-Rating Depression Scale.	W W ZUNG	Arch Gen Psychiatry	1965	14221692	Yes
150	14030	7015.0	349.0	174.5	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Kohler, C Milstein	Nature	1975	1172191	Yes
151	6867	6867.0	183.1	183.1	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
152	6852	6852.0	133.0	133.0	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
153	6841	6841.0	155.8	155.8	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
154	6825	6825.0	233.1	233.1	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
155	40492	6748.7	1353.4	225.6	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
156	6746	6746.0	153.8	153.8	Inflammation, atherosclerosis, and coronary artery disease.	Goran K Hansson	N Engl J Med	2005	15843671	No
157	6745	6745.0	156.6	156.6	Inflammation and metabolic disorders.	Gokhan S Hotamisligil	Nature	2006	17167474	No
158	6730	6730.0	217.6	217.6	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
159	6717	6717.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L WARREN	J Biol Chem	1959	13672998	Yes
160	13429	6714.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N MANTEL, W HAENSZEL	J Natl Cancer Inst	1959	13655060	Yes
161	6714	6714.0	288.3	288.3	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
162	13415	6707.5	449.5	224.8	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
163	13381	6690.5	311.4	155.7	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
164	6657	6657.0	577.0	577.0	Hallmarks of Cancer: New Dimensions.	Douglas Hanahan	Cancer Discov	2022	35022204	No
165	19805	6601.7	553.8	184.6	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
166	6596	6596.0	168.9	168.9	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
167	19786	6595.3	976.9	325.6	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
168	6546	6546.0	169.2	169.2	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
169	6538	6538.0	150.4	150.4	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
170	13034	6517.0	515.0	257.5	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
171	6474	6474.0	148.3	148.3	Free radicals in the physiological control of cell function.	Wulf Droge	Physiol Rev	2002	11773609	No
172	6466	6466.0	137.6	137.6	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
173	6456	6456.0	135.9	135.9	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
174	6456	6456.0	144.4	144.4	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
175	25715	6428.8	731.8	182.9	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
176	6426	6426.0	117.4	117.4	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
177	6422	6422.0	129.0	129.0	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
178	6400	6400.0	204.2	204.2	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
179	6378	6378.0	172.1	172.1	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
180	12745	6372.5	343.2	171.6	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
181	12707	6353.5	483.5	241.8	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
182	18925	6308.3	578.0	192.7	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
183	6250	6250.0	141.1	141.1	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
184	12479	6239.5	266.0	133.0	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
185	6237	6237.0	78.9	78.9	The Environment And Disease: Association Or Causation?	A B HILL	Proc R Soc Med	1965	14283879	Yes
186	12471	6235.5	284.0	142.0	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
187	6234	6234.0	134.8	134.8	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
188	12369	6184.5	297.0	148.5	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
189	6157	6157.0	186.4	186.4	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
190	12285	6142.5	441.7	220.8	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
191	24417	6104.2	718.2	179.6	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
192	6092	6092.0	152.3	152.3	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
193	6050	6050.0	151.2	151.2	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
194	6044	6044.0	155.8	155.8	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
195	24042	6010.5	578.6	144.7	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
196	23955	5988.8	782.7	195.7	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
197	11964	5982.0	393.1	196.6	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
198	11942	5971.0	250.3	125.2	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jurgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
199	5954	5954.0	144.0	144.0	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
200	5944	5944.0	151.8	151.8	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
201	5898	5898.0	142.4	142.4	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
202	5881	5881.0	232.1	232.1	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
203	5871	5871.0	221.0	221.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
204	5866	5866.0	179.1	179.1	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
205	11716	5858.0	283.2	141.6	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
206	11686	5843.0	242.0	121.0	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
207	5813	5813.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D HARMAN	J Gerontol	1956	13332224	Yes
208	5812	5812.0	215.5	215.5	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
209	17435	5811.7	640.4	213.5	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
210	11553	5776.5	304.3	152.2	Ab initio molecular dynamics for liquid metals.	G Kresse, J Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
211	11473	5736.5	700.6	350.3	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
212	11470	5735.0	535.1	267.6	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
213	5730	5730.0	119.2	119.2	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
214	5728	5728.0	142.1	142.1	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
215	11455	5727.5	192.9	96.5	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T OMURA, R SATO	J Biol Chem	1964	14209971	Yes
216	5724	5724.0	95.8	95.8	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
217	11414	5707.0	0.0	0.0	A series of normal stages in the development of the chick embryo.	V HAMBURGER, H L HAMILTON	J Morphol	1951	24539719	Yes
218	5690	5690.0	248.9	248.9	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniel Lakens	Front Psychol	2013	24324449	No
219	17007	5669.0	656.2	218.7	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
220	16919	5639.7	661.4	220.5	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
221	5620	5620.0	164.9	164.9	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
222	5615	5615.0	89.3	89.3	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
223	11229	5614.5	255.5	127.8	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stephane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
224	11162	5581.0	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L HODGKIN, A F HUXLEY	J Physiol	1952	12991237	Yes
225	16732	5577.3	501.3	167.1	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
226	5568	5568.0	118.8	118.8	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
227	11093	5546.5	365.2	182.6	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
228	16588	5529.3	403.2	134.4	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
229	11012	5506.0	238.4	119.2	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
230	10932	5466.0	284.6	142.3	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
231	5441	5441.0	103.3	103.3	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
232	16318	5439.3	563.7	187.9	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
233	5436	5436.0	53.7	53.7	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P LAUREN	Acta Pathol Microbiol Scand	1965	14320675	Yes
234	5403	5403.0	136.0	136.0	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
235	10802	5401.0	299.6	149.8	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
236	10775	5387.5	228.3	114.2	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
237	5386	5386.0	128.4	128.4	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
238	5379	5379.0	104.7	104.7	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
239	26830	5366.0	719.5	143.9	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
240	10672	5336.0	252.0	126.0	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
241	5312	5312.0	160.3	160.3	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
242	5308	5308.0	134.6	134.6	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
243	10578	5289.0	180.7	90.3	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
244	10567	5283.5	168.1	84.0	Functional Evaluation: The Barthel Index.	F I MAHONEY, D W BARTHEL	Md State Med J	1965	14258950	Yes
245	5271	5271.0	151.5	151.5	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
246	21071	5267.8	653.6	163.4	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Lowe	Arch Intern Med	2006	16717171	Yes
247	10526	5263.0	368.4	184.2	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
248	5254	5254.0	125.8	125.8	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
249	5233	5233.0	188.6	188.6	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
250	15691	5230.3	508.6	169.5	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
251	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J SCHEIDEGGER	Int Arch Allergy Appl Immunol	1955	13262900	Yes
252	10417	5208.5	364.5	182.2	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
253	5206	5206.0	68.6	68.6	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
254	5162	5162.0	101.7	101.7	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
255	10295	5147.5	265.0	132.5	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
256	10274	5137.0	271.6	135.8	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schagger, G von Jagow	Anal Biochem	1987	2449095	Yes
257	5125	5125.0	144.2	144.2	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
258	5122	5122.0	188.5	188.5	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
259	25550	5110.0	1022.6	204.5	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
260	15317	5105.7	480.5	160.2	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
261	10206	5103.0	238.8	119.4	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
262	15288	5096.0	663.8	221.3	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
263	5085	5085.0	113.4	113.4	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
264	25337	5067.4	414.9	83.0	An inventory for measuring depression.	A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH	Arch Gen Psychiatry	1961	13688369	Yes
265	5056	5056.0	92.1	92.1	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
266	10024	5012.0	225.2	112.6	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
267	14999	4999.7	540.5	180.2	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
268	4982	4982.0	115.0	115.0	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
269	19924	4981.0	311.2	77.8	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE	Biochem Pharmacol	1961	13726518	Yes
270	9961	4980.5	363.3	181.7	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
271	9918	4959.0	247.6	123.8	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
272	4950	4950.0	122.9	122.9	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
273	34479	4925.6	744.2	106.3	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
274	4925	4925.0	133.5	133.5	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
275	9830	4915.0	398.2	199.1	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
276	4910	4910.0	156.2	156.2	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
277	4892	4892.0	97.2	97.2	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
278	9780	4890.0	348.6	174.3	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
279	9773	4886.5	231.0	115.5	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
280	14656	4885.3	392.8	130.9	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
281	9739	4869.5	371.6	185.8	The qualitative content analysis process.	Satu Elo, Helvi Kyngas	J Adv Nurs	2008	18352969	Yes
282	4867	4867.0	202.5	202.5	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
283	4845	4845.0	139.8	139.8	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
284	14528	4842.7	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G GORNALL, C J BARDAWILL, M M DAVID	J Biol Chem	1949	18110453	Yes
285	4837	4837.0	104.3	104.3	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
286	24183	4836.6	914.0	182.8	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
287	4829	4829.0	41.0	41.0	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L HAYFLICK	Exp Cell Res	1965	14315085	Yes
288	4815	4815.0	107.3	107.3	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
289	4814	4814.0	104.9	104.9	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
290	14439	4813.0	355.4	118.5	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
291	4805	4805.0	57.3	57.3	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M RODBELL	J Biol Chem	1964	14169133	Yes
292	14362	4787.3	310.6	103.5	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
293	4784	4784.0	104.4	104.4	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
294	9547	4773.5	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H KELLGREN, J S LAWRENCE	Ann Rheum Dis	1957	13498604	Yes
295	9527	4763.5	159.1	79.5	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
296	9526	4763.0	259.5	129.8	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
297	4759	4759.0	144.8	144.8	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
298	9471	4735.5	236.8	118.4	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
299	4714	4714.0	263.0	263.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V BORN	Nature	1962	13871375	Yes
300	4710	4710.0	94.1	94.1	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
301	4705	4705.0	155.9	155.9	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
302	9410	4705.0	294.1	147.1	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoc, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
303	9407	4703.5	230.2	115.1	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
304	9401	4700.5	136.3	68.2	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
305	4697	4697.0	96.3	96.3	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
306	4695	4695.0	174.8	174.8	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
307	4690	4690.0	49.1	49.1	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
308	4683	4683.0	127.1	127.1	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
309	4679	4679.0	129.2	129.2	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
310	18683	4670.8	519.7	129.9	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
311	4665	4665.0	120.4	120.4	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
312	4637	4637.0	165.0	165.0	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
313	9264	4632.0	203.2	101.6	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
314	4618	4618.0	91.1	91.1	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
315	9236	4618.0	264.9	132.4	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
316	13818	4606.0	501.6	167.2	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
317	4603	4603.0	104.6	104.6	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
318	13732	4577.3	470.9	157.0	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
319	4571	4571.0	114.8	114.8	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
320	9124	4562.0	241.6	120.8	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
321	18248	4562.0	807.3	201.8	fastp: an ultra-fast all-in-one FASTQ preprocessor.	Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu	Bioinformatics	2018	30423086	Yes
322	4556	4556.0	96.8	96.8	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
323	9099	4549.5	209.3	104.7	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
324	4549	4549.0	87.3	87.3	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
325	4547	4547.0	164.1	164.1	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
326	4542	4542.0	91.1	91.1	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
327	4539	4539.0	107.7	107.7	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
328	4521	4521.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B DE B WEIR	J Physiol	1949	15394301	Yes
329	4520	4520.0	135.6	135.6	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
330	4519	4519.0	84.5	84.5	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
331	4513	4513.0	113.7	113.7	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
332	4506	4506.0	112.8	112.8	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
333	9003	4501.5	210.4	105.2	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
334	26879	4479.8	866.0	144.3	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
335	4465	4465.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
336	4453	4453.0	91.5	91.5	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
337	8878	4439.0	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T LITCHFIELD, F WILCOXON	J Pharmacol Exp Ther	1949	18152921	Yes
338	4436	4436.0	107.2	107.2	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
339	26498	4416.3	911.1	151.8	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
340	4416	4416.0	102.4	102.4	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
341	4414	4414.0	112.9	112.9	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
342	4410	4410.0	125.5	125.5	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
343	22034	4406.8	1244.5	248.9	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
344	4401	4401.0	93.5	93.5	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
345	43938	4393.8	1063.4	106.3	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin,	Bioinformatics	2009	19505943	Yes
346	8772	4386.0	161.9	81.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
347	8745	4372.5	222.6	111.3	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
348	8734	4367.0	218.4	109.2	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
349	4361	4361.0	120.0	120.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
350	4355	4355.0	224.9	224.9	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
351	4346	4346.0	128.3	128.3	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
352	4342	4342.0	107.9	107.9	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
353	8673	4336.5	265.5	132.8	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
354	4336	4336.0	111.0	111.0	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
355	4329	4329.0	150.8	150.8	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
356	4324	4324.0	113.8	113.8	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
357	8633	4316.5	226.9	113.5	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
358	4305	4305.0	94.6	94.6	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
359	4304	4304.0	142.4	142.4	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
360	4302	4302.0	101.5	101.5	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
361	17200	4300.0	603.9	151.0	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
362	8579	4289.5	460.7	230.3	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M HUNTER, F C GREENWOOD	Nature	1962	14450081	Yes
363	4286	4286.0	171.5	171.5	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
364	4283	4283.0	87.6	87.6	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
365	4280	4280.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M ABERCROMBIE	Anat Rec	1946	21015608	Yes
366	4271	4271.0	112.6	112.6	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
367	4271	4271.0	74.6	74.6	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
368	8540	4270.0	180.9	90.5	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
369	4266	4266.0	121.1	121.1	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	D Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
370	4263	4263.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T NASH	Biochem J	1953	13105648	Yes
371	4258	4258.0	75.4	75.4	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
372	4255	4255.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H EAGLE	Science	1959	13675766	Yes
373	4248	4248.0	50.5	50.5	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
374	4245	4245.0	86.9	86.9	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
375	4240	4240.0	111.8	111.8	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
376	4237	4237.0	80.8	80.8	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
377	4232	4232.0	108.5	108.5	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
378	4230	4230.0	100.7	100.7	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
379	4226	4226.0	91.0	91.0	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
380	4222	4222.0	93.6	93.6	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
381	8428	4214.0	195.8	97.9	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
382	4211	4211.0	175.6	175.6	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
383	4211	4211.0	86.7	86.7	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
384	4208	4208.0	71.7	71.7	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
385	4205	4205.0	116.5	116.5	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
386	4201	4201.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P DOLE	J Clin Invest	1956	13286333	Yes
387	8394	4197.0	216.7	108.3	Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii.	Daniel E Voth, Robert A Heinzen	Cell Microbiol	2007	17381428	No
388	12586	4195.3	319.3	106.4	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
389	4189	4189.0	86.4	86.4	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
390	4166	4166.0	0.0	0.0	The determination of enzyme inhibitor constants.	M DIXON	Biochem J	1953	13093635	Yes
391	4158	4158.0	112.0	112.0	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
392	4153	4153.0	127.9	127.9	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
393	16579	4144.8	366.0	91.5	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
394	4141	4141.0	102.6	102.6	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
395	8277	4138.5	177.1	88.5	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
396	4124	4124.0	100.9	100.9	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
397	4111	4111.0	134.8	134.8	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
398	36962	4106.9	1102.2	122.5	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
399	28632	4090.3	973.2	139.0	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
400	8176	4088.0	201.2	100.6	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
401	8173	4086.5	195.4	97.7	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
402	4076	4076.0	106.4	106.4	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
403	4062	4062.0	145.1	145.1	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
404	12169	4056.3	284.0	94.7	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
405	4054	4054.0	91.0	91.0	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
406	12159	4053.0	380.5	126.8	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
407	12132	4044.0	324.4	108.1	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
408	4037	4037.0	116.2	116.2	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
409	16146	4036.5	647.4	161.8	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
410	8072	4036.0	152.1	76.0	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
411	8061	4030.5	151.7	75.8	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
412	4025	4025.0	102.9	102.9	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
413	4024	4024.0	82.2	82.2	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
414	4022	4022.0	82.2	82.2	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
415	4020	4020.0	106.8	106.8	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
416	7999	3999.5	260.4	130.2	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
417	3990	3990.0	93.7	93.7	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
418	3990	3990.0	87.3	87.3	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
419	3990	3990.0	113.5	113.5	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
420	3984	3984.0	127.7	127.7	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
421	3983	3983.0	118.7	118.7	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
422	35812	3979.1	758.5	84.3	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
423	7951	3975.5	212.3	106.2	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
424	3972	3972.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L WATSON	J Biophys Biochem Cytol	1958	13563554	Yes
425	3970	3970.0	94.6	94.6	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
426	3969	3969.0	119.5	119.5	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
427	11864	3954.7	1059.2	353.1	MEGA11: Molecular Evolutionary Genetics Analysis Version 11.	Koichiro Tamura, Glen Stecher, Sudhir Kumar	Mol Biol Evol	2021	33892491	Yes
428	3947	3947.0	96.1	96.1	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
429	7892	3946.0	429.0	214.5	The biology, function, and biomedical applications of exosomes.	Raghu Kalluri, Valerie S LeBleu	Science	2020	32029601	No
430	3928	3928.0	143.4	143.4	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
431	7850	3925.0	219.0	109.5	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
432	3924	3924.0	110.2	110.2	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
433	3922	3922.0	120.4	120.4	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
434	3918	3918.0	102.8	102.8	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
435	3915	3915.0	76.2	76.2	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
436	3915	3915.0	63.8	63.8	Disc Electrophoresis. I. Background And Theory.	L ORNSTEIN	Ann N Y Acad Sci	1964	14240533	Yes
437	3914	3914.0	177.5	177.5	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
438	3906	3906.0	118.8	118.8	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	Francois Rousset	Mol Ecol Resour	2008	21585727	Yes
439	3897	3897.0	99.3	99.3	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
440	3895	3895.0	99.9	99.9	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
441	7778	3889.0	179.1	89.5	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
442	3881	3881.0	89.2	89.2	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
443	3878	3878.0	125.8	125.8	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
444	15500	3875.0	859.1	214.8	Rayyan-a web and mobile app for systematic reviews.	Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid	Syst Rev	2016	27919275	Yes
445	3870	3870.0	91.1	91.1	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
446	7723	3861.5	229.2	114.6	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
447	3859	3859.0	89.7	89.7	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
448	3855	3855.0	122.1	122.1	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
449	3841	3841.0	121.1	121.1	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
450	7673	3836.5	238.4	119.2	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
451	3836	3836.0	102.1	102.1	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
452	3817	3817.0	98.4	98.4	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
453	3807	3807.0	91.7	91.7	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
454	7613	3806.5	277.6	138.8	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
455	7606	3803.0	180.6	90.3	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
456	3802	3802.0	89.8	89.8	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brunger	Nature	1992	18481394	Yes
457	3800	3800.0	77.3	77.3	TGF-beta signal transduction.	J Massague	Annu Rev Biochem	1998	9759503	No
458	3799	3799.0	79.3	79.3	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
459	7587	3793.5	388.8	194.4	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
460	7549	3774.5	164.1	82.0	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
461	3770	3770.0	167.5	167.5	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
462	3760	3760.0	189.7	189.7	High-performance medicine: the convergence of human and artificial intelligence.	Eric J Topol	Nat Med	2019	30617339	No
463	3759	3759.0	65.0	65.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
464	3753	3753.0	107.0	107.0	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
465	11240	3746.7	264.3	88.1	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
466	11184	3728.0	213.1	71.0	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
467	3725	3725.0	65.7	65.7	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
468	11154	3718.0	256.7	85.6	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
469	3715	3715.0	76.8	76.8	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
470	11127	3709.0	257.9	86.0	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
471	3705	3705.0	68.2	68.2	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
472	11109	3703.0	301.4	100.5	GSVA: gene set variation analysis for microarray and RNA-seq data.	Sonja Hanzelmann, Robert Castelo, Justin Guinney	BMC Bioinformatics	2013	23323831	Yes
473	3701	3701.0	101.6	101.6	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
474	3699	3699.0	126.2	126.2	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
475	3690	3690.0	118.4	118.4	The Danish Civil Registration System.	Carsten Bocker Pedersen	Scand J Public Health	2011	21775345	Yes
476	3681	3681.0	102.3	102.3	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
477	3677	3677.0	115.7	115.7	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
478	3675	3675.0	127.5	127.5	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
479	7342	3671.0	586.3	293.1	Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2021	33885785	Yes
480	3668	3668.0	81.7	81.7	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
481	3654	3654.0	135.0	135.0	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
482	40164	3651.3	818.7	74.4	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
483	3651	3651.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A MILLER	Psychol Rev	1956	13310704	Yes
484	7297	3648.5	170.2	85.1	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
485	7294	3647.0	129.4	64.7	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
486	18217	3643.4	650.0	130.0	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	Ann Intern Med	2009	19622511	No
487	7278	3639.0	359.7	179.8	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H HUBEL, T N WIESEL	J Physiol	1962	14449617	Yes
488	3639	3639.0	170.8	170.8	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
489	3630	3630.0	71.3	71.3	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
490	3628	3628.0	84.3	84.3	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
491	3627	3627.0	55.4	55.4	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
492	7241	3620.5	203.5	101.8	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
493	3617	3617.0	140.1	140.1	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
494	7227	3613.5	200.1	100.0	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
495	3612	3612.0	106.8	106.8	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
496	3610	3610.0	108.2	108.2	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
497	3609	3609.0	79.6	79.6	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
498	3603	3603.0	166.1	166.1	Toward understanding the origin and evolution of cellular organisms.	Minoru Kanehisa	Protein Sci	2019	31441146	No
499	7202	3601.0	138.3	69.2	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
500	3599	3599.0	142.3	142.3	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
501	3587	3587.0	67.1	67.1	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
502	3585	3585.0	85.9	85.9	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
503	3584	3584.0	92.0	92.0	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
504	3582	3582.0	76.8	76.8	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
505	7160	3580.0	207.1	103.5	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
506	3556	3556.0	86.0	86.0	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
507	3550	3550.0	110.7	110.7	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
508	3546	3546.0	150.3	150.3	Hepatocellular Carcinoma.	Augusto Villanueva	N Engl J Med	2019	30970190	No
509	7079	3539.5	145.2	72.6	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
510	7078	3539.0	196.6	98.3	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
511	7069	3534.5	133.7	66.8	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
512	7063	3531.5	211.4	105.7	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
513	17618	3523.6	611.5	122.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	BMJ	2009	19622551	No
514	3522	3522.0	57.0	57.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
515	3521	3521.0	94.8	94.8	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
516	3520	3520.0	77.7	77.7	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
517	17589	3517.8	493.5	98.7	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
518	3512	3512.0	51.3	51.3	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F WOESSNER	Arch Biochem Biophys	1961	13786180	Yes
519	3511	3511.0	83.6	83.6	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
520	7019	3509.5	162.0	81.0	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
521	3507	3507.0	87.9	87.9	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
522	3491	3491.0	69.8	69.8	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
523	3489	3489.0	57.4	57.4	Statistical estimations in enzyme kinetics.	G N WILKINSON	Biochem J	1961	13785321	Yes
524	6973	3486.5	173.8	86.9	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
525	27825	3478.1	592.7	74.1	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
526	6953	3476.5	182.6	91.3	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
527	3471	3471.0	94.5	94.5	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
528	3468	3468.0	82.8	82.8	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
529	3464	3464.0	65.5	65.5	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
530	6915	3457.5	143.7	71.8	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
531	3454	3454.0	178.8	178.8	Obesity: global epidemiology and pathogenesis.	Matthias Bluher	Nat Rev Endocrinol	2019	30814686	No
532	3453	3453.0	70.7	70.7	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
533	3450	3450.0	106.3	106.3	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
534	6898	3449.0	180.9	90.5	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
535	6885	3442.5	215.2	107.6	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
536	6879	3439.5	162.2	81.1	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
537	3432	3432.0	91.8	91.8	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
538	6862	3431.0	206.9	103.5	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
539	3429	3429.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W KAUZMANN	Adv Protein Chem	1959	14404936	Yes
540	10251	3417.0	285.1	95.0	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
541	6806	3403.0	219.0	109.5	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
542	3400	3400.0	68.8	68.8	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
543	6793	3396.5	170.2	85.1	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
544	6780	3390.0	211.9	106.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
545	6777	3388.5	161.9	81.0	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
546	3387	3387.0	99.4	99.4	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
547	6770	3385.0	186.3	93.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
548	10153	3384.3	98.3	32.8	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C GREENWOOD, W M HUNTER, J S GLOVER	Biochem J	1963	14097352	Yes
549	3384	3384.0	165.2	165.2	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
550	10152	3384.0	279.6	93.2	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
551	6766	3383.0	56.6	28.3	The serial cultivation of human diploid cell strains.	L HAYFLICK, P S MOORHEAD	Exp Cell Res	1961	13905658	Yes
552	3382	3382.0	75.9	75.9	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
553	3381	3381.0	113.4	113.4	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
554	3378	3378.0	78.2	78.2	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
555	20258	3376.3	951.3	158.5	DADA2: High-resolution sample inference from Illumina amplicon data.	Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes	Nat Methods	2016	27214047	Yes
556	6751	3375.5	271.4	135.7	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
557	3371	3371.0	107.2	107.2	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
558	3369	3369.0	68.5	68.5	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
559	10099	3366.3	480.4	160.1	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
560	3364	3364.0	76.5	76.5	Photoelectrochemical cells.	M Gratzel	Nature	2001	11713540	Yes
561	6710	3355.0	104.7	52.4	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
562	3350	3350.0	60.6	60.6	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
563	3350	3350.0	52.1	52.1	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L HORN	Psychometrika	1965	14306381	Yes
564	3349	3349.0	75.8	75.8	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
565	3344	3344.0	100.2	100.2	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
566	3343	3343.0	96.0	96.0	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
567	3338	3338.0	67.9	67.9	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
568	6669	3334.5	163.7	81.8	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
569	3332	3332.0	88.2	88.2	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
570	3322	3322.0	78.3	78.3	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
571	9927	3309.0	183.6	61.2	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
572	3308	3308.0	111.9	111.9	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
573	3307	3307.0	127.6	127.6	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
574	3306	3306.0	71.6	71.6	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
575	13220	3305.0	491.4	122.8	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
576	3303	3303.0	83.4	83.4	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
577	3300	3300.0	67.3	67.3	TGFbeta in Cancer.	Joan Massague	Cell	2008	18662538	No
578	9898	3299.3	415.5	138.5	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
579	3299	3299.0	46.1	46.1	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A YPHANTIS	Biochemistry	1964	14155091	Yes
580	6594	3297.0	304.6	152.3	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
581	6593	3296.5	163.1	81.5	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
582	3294	3294.0	75.1	75.1	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
583	3285	3285.0	87.8	87.8	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
584	3271	3271.0	107.3	107.3	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
585	3268	3268.0	69.3	69.3	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
586	3266	3266.0	107.9	107.9	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
587	3258	3258.0	66.3	66.3	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
588	3258	3258.0	72.4	72.4	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
589	3256	3256.0	110.8	110.8	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
590	3255	3255.0	66.1	66.1	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
591	3254	3254.0	99.0	99.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
592	3249	3249.0	92.9	92.9	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
593	3247	3247.0	63.8	63.8	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
594	12968	3242.0	298.9	74.7	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
595	3236	3236.0	59.3	59.3	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
596	3235	3235.0	27.0	27.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F LYON	Nature	1961	13764598	Yes
597	3235	3235.0	87.6	87.6	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
598	3229	3229.0	143.3	143.3	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
599	6446	3223.0	111.4	55.7	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
600	6440	3220.0	132.6	66.3	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
601	3214	3214.0	66.7	66.7	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
602	12850	3212.5	361.5	90.4	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
603	6412	3206.0	164.3	82.2	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
604	6403	3201.5	141.4	70.7	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
605	3200	3200.0	73.8	73.8	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
606	3195	3195.0	74.7	74.7	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
607	3189	3189.0	126.6	126.6	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
608	9567	3189.0	237.8	79.3	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
609	6369	3184.5	132.7	66.3	Emergence of scaling in random networks	A L Barabasi, R Albert	Science	1999	10521342	Yes
610	3184	3184.0	73.8	73.8	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
611	3182	3182.0	96.4	96.4	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
612	9531	3177.0	192.6	64.2	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
613	3173	3173.0	114.8	114.8	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
614	3172	3172.0	74.3	74.3	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
615	3171	3171.0	85.1	85.1	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
616	6339	3169.5	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S REITMAN, S FRANKEL	Am J Clin Pathol	1957	13458125	Yes
617	3166	3166.0	77.7	77.7	The transforming growth factor-beta family.	J Massague	Annu Rev Cell Biol	1990	2177343	No
618	6332	3166.0	134.4	67.2	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
619	3160	3160.0	68.6	68.6	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
620	6311	3155.5	148.7	74.3	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
621	3143	3143.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O OUCHTERLONY	Prog Allergy	1958	13578996	Yes
622	3140	3140.0	73.5	73.5	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
623	3131	3131.0	93.9	93.9	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
624	3129	3129.0	131.3	131.3	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
625	9380	3126.7	310.9	103.6	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
626	9309	3103.0	214.6	71.5	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
627	6198	3099.0	193.5	96.8	Extracellular vesicles: exosomes, microvesicles, and friends.	Graca Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
628	6191	3095.5	126.4	63.2	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
629	9281	3093.7	296.7	98.9	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
630	6187	3093.5	146.9	73.5	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
631	12371	3092.8	283.7	70.9	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
632	3072	3072.0	29.8	29.8	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P MITCHELL	Nature	1961	13771349	Yes
633	3068	3068.0	89.6	89.6	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
634	3067	3067.0	83.9	83.9	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
635	3067	3067.0	47.3	47.3	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S HAKOMORI	J Biochem	1964	14135466	Yes
636	9192	3064.0	201.0	67.0	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
637	3062	3062.0	70.3	70.3	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
638	3059	3059.0	130.2	130.2	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
639	3053	3053.0	57.6	57.6	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
640	3052	3052.0	95.0	95.0	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
641	6098	3049.0	187.5	93.8	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
642	3049	3049.0	93.8	93.8	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
643	3048	3048.0	74.3	74.3	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
644	3042	3042.0	0.0	0.0	The genetical structure of populations.	S WRIGHT	Ann Eugen	1951	24540312	Yes
645	3040	3040.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I SELDINGER	Acta Radiol (Stockh)	1953	13057644	Yes
646	3039	3039.0	55.1	55.1	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
647	6066	3033.0	235.1	117.5	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
648	3033	3033.0	66.3	66.3	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
649	6065	3032.5	170.8	85.4	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
650	9091	3030.3	175.3	58.4	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
651	3029	3029.0	84.5	84.5	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
652	3028	3028.0	133.0	133.0	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
653	3022	3022.0	58.8	58.8	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
654	6041	3020.5	174.4	87.2	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
655	3010	3010.0	0.0	0.0	A study of fixation for electron microscopy.	G E PALADE	J Exp Med	1952	14927794	Yes
656	3008	3008.0	70.6	70.6	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
657	3003	3003.0	57.7	57.7	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
658	5975	2987.5	196.1	98.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
659	2987	2987.0	74.9	74.9	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
660	5971	2985.5	177.5	88.8	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
661	5969	2984.5	200.9	100.5	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
662	5965	2982.5	181.1	90.5	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
663	5960	2980.0	124.7	62.4	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
664	2979	2979.0	91.3	91.3	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
665	2978	2978.0	61.4	61.4	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
666	2978	2978.0	79.4	79.4	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
667	2977	2977.0	116.1	116.1	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
668	2976	2976.0	73.5	73.5	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
669	8928	2976.0	194.6	64.9	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
670	2975	2975.0	51.9	51.9	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
671	2967	2967.0	76.7	76.7	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
672	2966	2966.0	96.0	96.0	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
673	2959	2959.0	87.6	87.6	Receiver operating characteristic curve in diagnostic test assessment.	Jayawant N Mandrekar	J Thorac Oncol	2010	20736804	No
674	2957	2957.0	44.6	44.6	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
675	2957	2957.0	69.5	69.5	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
676	2955	2955.0	59.2	59.2	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
677	17706	2951.0	379.6	63.3	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
678	8851	2950.3	241.7	80.6	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
679	8839	2946.3	349.7	116.6	Fast and sensitive protein alignment using DIAMOND.	Benjamin Buchfink, Chao Xie, Daniel H Huson	Nat Methods	2015	25402007	Yes
680	2939	2939.0	60.4	60.4	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
681	2938	2938.0	75.4	75.4	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
682	2938	2938.0	55.7	55.7	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
683	5873	2936.5	124.7	62.4	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
684	2936	2936.0	61.6	61.6	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
685	2934	2934.0	52.6	52.6	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
686	8799	2933.0	430.9	143.6	SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.	Antoine Daina, Olivier Michielin, Vincent Zoete	Sci Rep	2017	28256516	Yes
687	2932	2932.0	86.7	86.7	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
688	2928	2928.0	86.8	86.8	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
689	2928	2928.0	49.0	49.0	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
690	5848	2924.0	151.2	75.6	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	G Kresse, J Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
691	5843	2921.5	130.0	65.0	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
692	2921	2921.0	66.7	66.7	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
693	8740	2913.3	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J HAVEL, H A EDER, J H BRAGDON	J Clin Invest	1955	13252080	Yes
694	5826	2913.0	161.8	80.9	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
695	2908	2908.0	70.6	70.6	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
696	5815	2907.5	154.1	77.0	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
697	5809	2904.5	249.9	125.0	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
698	2903	2903.0	70.5	70.5	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
699	2899	2899.0	95.5	95.5	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
700	2897	2897.0	0.0	0.0	Notes on sugar determination.	M SMOGYI	J Biol Chem	1952	14938350	Yes
701	5791	2895.5	115.6	57.8	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
702	2895	2895.0	61.3	61.3	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
703	5780	2890.0	195.3	97.7	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
704	2889	2889.0	48.6	48.6	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A GEHAN	Biometrika	1965	14341275	Yes
705	5776	2888.0	174.1	87.0	Accurate and simple analytic representation of the electron-gas correlation energy.	J P Perdew, Y Wang	Phys Rev B Condens Matter	1992	10001404	Yes
706	2881	2881.0	83.6	83.6	Separation of leukocytes from blood and bone marrow. Introduction.	A Boyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
707	2881	2881.0	72.6	72.6	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
708	5758	2879.0	182.5	91.2	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
709	2879	2879.0	92.8	92.8	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
710	2877	2877.0	127.7	127.7	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
711	2877	2877.0	83.0	83.0	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
712	2876	2876.0	50.5	50.5	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
713	5750	2875.0	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D WATSON, F H CRICK	Nature	1953	13054692	Yes
714	8603	2867.7	225.1	75.0	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
715	2863	2863.0	66.1	66.1	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
716	2861	2861.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C SCHNEIDER	J Biol Chem	1945	21005736	Yes
717	2858	2858.0	66.6	66.6	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
718	8554	2851.3	246.9	82.3	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
719	2845	2845.0	64.6	64.6	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
720	2845	2845.0	57.1	57.1	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
721	2845	2845.0	0.0	0.0	A study of the adrenotropic receptors.	R P AHLQUIST	Am J Physiol	1948	18882199	Yes
722	5688	2844.0	174.7	87.3	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
723	2839	2839.0	96.6	96.6	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
724	11354	2838.5	265.0	66.2	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
725	2837	2837.0	112.3	112.3	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
726	5674	2837.0	136.2	68.1	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
727	2837	2837.0	109.0	109.0	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
728	5665	2832.5	202.6	101.3	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
729	2831	2831.0	146.7	146.7	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
730	8492	2830.7	216.4	72.1	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
731	2830	2830.0	111.1	111.1	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
732	5659	2829.5	158.9	79.5	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
733	5655	2827.5	109.9	55.0	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
734	2824	2824.0	64.2	64.2	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
735	2824	2824.0	67.2	67.2	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
736	8468	2822.7	243.8	81.3	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
737	5637	2818.5	132.8	66.4	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
738	2817	2817.0	71.3	71.3	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
739	5629	2814.5	134.4	67.2	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
740	2812	2812.0	99.3	99.3	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
741	2809	2809.0	102.7	102.7	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
742	8423	2807.7	334.5	111.5	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
743	5614	2807.0	313.5	156.8	A modified uronic acid carbazole reaction.	T BITTER, H M MUIR	Anal Biochem	1962	13971270	Yes
744	5612	2806.0	152.2	76.1	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
745	2806	2806.0	23.9	23.9	Satellite cell of skeletal muscle fibers.	A MAURO	J Biophys Biochem Cytol	1961	13768451	Yes
746	2805	2805.0	65.1	65.1	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
747	5602	2801.0	126.8	63.4	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
748	2800	2800.0	99.5	99.5	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
749	2797	2797.0	61.0	61.0	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
750	8388	2796.0	208.7	69.6	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
751	5587	2793.5	125.2	62.6	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
752	2790	2790.0	68.9	68.9	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
753	2790	2790.0	62.1	62.1	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
754	5580	2790.0	76.0	38.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G MARTIN, B N AMES	J Biol Chem	1961	13767412	Yes
755	11154	2788.5	318.7	79.7	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
756	2787	2787.0	61.5	61.5	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
757	11139	2784.8	293.3	73.3	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
758	5569	2784.5	109.2	54.6	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J SILNESS, H LOE	Acta Odontol Scand	1964	14158464	Yes
759	2784	2784.0	88.0	88.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
760	2784	2784.0	84.1	84.1	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
761	5565	2782.5	160.5	80.2	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
762	2782	2782.0	174.2	174.2	User's guide to correlation coefficients.	Haldun Akoglu	Turk J Emerg Med	2018	30191186	No
763	5562	2781.0	167.4	83.7	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
764	2779	2779.0	75.3	75.3	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
765	11109	2777.2	319.8	80.0	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
766	2777	2777.0	62.0	62.0	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
767	2777	2777.0	52.7	52.7	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
768	2777	2777.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
769	44359	2772.4	1343.6	84.0	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
770	2771	2771.0	60.2	60.2	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
771	2764	2764.0	68.2	68.2	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
772	5523	2761.5	218.6	109.3	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
773	2760	2760.0	65.9	65.9	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
774	5517	2758.5	133.8	66.9	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
775	5512	2756.0	172.6	86.3	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
776	2754	2754.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L SVENNERHOLM	Biochim Biophys Acta	1957	13436486	Yes
777	8256	2752.0	214.8	71.6	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni Gabaldon	Bioinformatics	2009	19505945	Yes
778	2752	2752.0	108.5	108.5	Deep learning in neural networks: an overview.	Jurgen Schmidhuber	Neural Netw	2015	25462637	No
779	5502	2751.0	144.1	72.0	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
780	5501	2750.5	138.0	69.0	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
781	2749	2749.0	50.5	50.5	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
782	8239	2746.3	195.6	65.2	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
783	2745	2745.0	59.0	59.0	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
784	5485	2742.5	119.7	59.9	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
785	5484	2742.0	107.6	53.8	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
786	5469	2734.5	109.6	54.8	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
787	5459	2729.5	103.4	51.7	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
788	2729	2729.0	74.4	74.4	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
789	5456	2728.0	234.8	117.4	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
790	2719	2719.0	55.2	55.2	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
791	2719	2719.0	56.4	56.4	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
792	5437	2718.5	174.5	87.2	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
793	8153	2717.7	174.6	58.2	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
794	5435	2717.5	131.7	65.8	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
795	2714	2714.0	56.4	56.4	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
796	2710	2710.0	65.2	65.2	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
797	5419	2709.5	157.2	78.6	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
798	2703	2703.0	73.0	73.0	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
799	5405	2702.5	158.0	79.0	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
800	10802	2700.5	226.4	56.6	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
801	2698	2698.0	74.7	74.7	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
802	2697	2697.0	82.6	82.6	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
803	2695	2695.0	51.0	51.0	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
804	5390	2695.0	112.6	56.3	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
805	2692	2692.0	109.7	109.7	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
806	2689	2689.0	63.5	63.5	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
807	5371	2685.5	172.6	86.3	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
808	5368	2684.0	72.5	36.2	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
809	8036	2678.7	194.8	64.9	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
810	2677	2677.0	61.6	61.6	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
811	2674	2674.0	70.4	70.4	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
812	10674	2668.5	264.6	66.2	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
813	2667	2667.0	76.7	76.7	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
814	2665	2665.0	65.9	65.9	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
815	2663	2663.0	133.6	133.6	The Global Epidemic of the Metabolic Syndrome.	Mohammad G Saklayen	Curr Hypertens Rep	2018	29480368	No
816	2660	2660.0	59.1	59.1	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
817	2659	2659.0	55.5	55.5	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
818	2658	2658.0	87.5	87.5	Working memory.	A Baddeley	Science	1992	1736359	No
819	5312	2656.0	127.2	63.6	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
820	2650	2650.0	57.2	57.2	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
821	2649	2649.0	72.4	72.4	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
822	2648	2648.0	108.2	108.2	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
823	2648	2648.0	73.2	73.2	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
824	2644	2644.0	76.7	76.7	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
825	5287	2643.5	137.9	69.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
826	10569	2642.2	223.3	55.8	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
827	2633	2633.0	116.2	116.2	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
828	2632	2632.0	70.7	70.7	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
829	5250	2625.0	160.9	80.5	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
830	2625	2625.0	62.4	62.4	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
831	5241	2620.5	116.3	58.1	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
832	5238	2619.0	0.0	0.0	Some quantitative uses of drug antagonists.	O ARUNLAKSHANA, H O SCHILD	Br J Pharmacol Chemother	1959	13651579	Yes
833	2618	2618.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
834	2615	2615.0	35.6	35.6	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
835	2615	2615.0	49.3	49.3	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
836	5224	2612.0	180.0	90.0	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
837	5218	2609.0	103.1	51.5	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
838	7826	2608.7	216.5	72.2	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
839	2604	2604.0	81.7	81.7	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
840	5207	2603.5	111.6	55.8	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
841	2597	2597.0	80.8	80.8	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
842	2595	2595.0	55.0	55.0	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
843	2590	2590.0	68.4	68.4	TGFβ signalling in context.	Joan Massague	Nat Rev Mol Cell Biol	2012	22992590	No
844	2587	2587.0	73.3	73.3	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
845	2586	2586.0	133.9	133.9	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
846	5169	2584.5	133.4	66.7	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
847	2582	2582.0	104.4	104.4	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
848	2579	2579.0	75.0	75.0	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
849	5155	2577.5	220.2	110.1	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
850	5155	2577.5	139.2	69.6	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
851	2570	2570.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R PORTER	Biochem J	1959	14434282	Yes
852	2569	2569.0	120.7	120.7	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
853	2569	2569.0	133.5	133.5	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
854	5137	2568.5	148.6	74.3	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
855	7689	2563.0	302.8	100.9	The behaviour change wheel: a new method for characterising and designing behaviour change interventions.	Susan Michie, Maartje M van Stralen, Robert West	Implement Sci	2011	21513547	No
856	2561	2561.0	82.8	82.8	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
857	12799	2559.8	288.1	57.6	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
858	2559	2559.0	77.2	77.2	A two process model of sleep regulation.	A A Borbely	Hum Neurobiol	1982	7185792	Yes
859	5116	2558.0	281.7	140.8	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
860	2558	2558.0	123.5	123.5	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S BOYDEN	J Exp Med	1962	13872176	Yes
861	2556	2556.0	80.6	80.6	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
862	5112	2556.0	71.4	35.7	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H LOE, J SILNESS	Acta Odontol Scand	1963	14121956	Yes
863	2552	2552.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O SMITHIES	Biochem J	1955	13276348	Yes
864	2550	2550.0	50.9	50.9	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
865	5099	2549.5	133.5	66.8	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
866	5093	2546.5	151.0	75.5	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
867	5091	2545.5	143.7	71.8	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
868	2544	2544.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M FITTS	J Exp Psychol	1954	13174710	Yes
869	5085	2542.5	122.0	61.0	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
870	2542	2542.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
871	5083	2541.5	164.2	82.1	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rossello-Mora	Proc Natl Acad Sci U S A	2009	19855009	Yes
872	2535	2535.0	63.5	63.5	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
873	5068	2534.0	131.3	65.7	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
874	5066	2533.0	135.5	67.8	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
875	2531	2531.0	60.5	60.5	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
876	2523	2523.0	61.5	61.5	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
877	2519	2519.0	70.4	70.4	Hazards of heavy metal contamination.	Lars Jarup	Br Med Bull	2003	14757716	No
878	5037	2518.5	162.6	81.3	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
879	5030	2515.0	96.2	48.1	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
880	2515	2515.0	51.1	51.1	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
881	2513	2513.0	44.3	44.3	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
882	2513	2513.0	77.4	77.4	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
883	2512	2512.0	96.4	96.4	Neutrophil extracellular traps in immunity and disease.	Venizelos Papayannopoulos	Nat Rev Immunol	2018	28990587	No
884	2511	2511.0	44.6	44.6	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
885	2510	2510.0	71.1	71.1	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
886	2507	2507.0	76.4	76.4	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
887	20018	2502.2	766.9	95.9	The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.	Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver Glockner	Nucleic Acids Res	2013	23193283	Yes
888	2499	2499.0	60.6	60.6	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
889	2497	2497.0	60.6	60.6	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
890	2497	2497.0	56.4	56.4	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
891	9983	2495.8	197.3	49.3	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
892	4991	2495.5	119.9	60.0	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
893	2495	2495.0	62.8	62.8	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
894	2493	2493.0	52.1	52.1	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
895	2491	2491.0	80.1	80.1	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
896	2488	2488.0	95.0	95.0	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
897	2487	2487.0	43.8	43.8	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
898	4973	2486.5	183.8	91.9	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
899	2484	2484.0	52.8	52.8	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
900	4965	2482.5	122.2	61.1	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
901	9926	2481.5	212.5	53.1	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
902	4960	2480.0	138.8	69.4	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
903	2476	2476.0	63.0	63.0	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
904	4952	2476.0	105.4	52.7	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
905	2475	2475.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S LENNOX	Virology	1955	13267987	Yes
906	2475	2475.0	58.4	58.4	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
907	4950	2475.0	172.3	86.2	Cancer immunotherapy using checkpoint blockade.	Antoni Ribas, Jedd D Wolchok	Science	2018	29567705	No
908	7422	2474.0	225.2	75.1	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
909	2474	2474.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G BERTANI	J Bacteriol	1951	14888646	Yes
910	4947	2473.5	93.4	46.7	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
911	7419	2473.0	156.6	52.2	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
912	2472	2472.0	114.3	114.3	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
913	2472	2472.0	28.1	28.1	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T HIGUCHI	J Pharm Sci	1963	14088963	Yes
914	4940	2470.0	106.7	53.4	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
915	2469	2469.0	64.9	64.9	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
916	9867	2466.8	459.4	114.8	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
917	4932	2466.0	95.4	47.7	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
918	2465	2465.0	47.5	47.5	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
919	2460	2460.0	58.8	58.8	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
920	2457	2457.0	74.9	74.9	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
921	2455	2455.0	53.1	53.1	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
922	4905	2452.5	113.0	56.5	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
923	4904	2452.0	142.9	71.5	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
924	2449	2449.0	62.9	62.9	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
925	2448	2448.0	62.4	62.4	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
926	7342	2447.3	259.5	86.5	Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.	Jack Bowden, George Davey Smith, Stephen Burgess	Int J Epidemiol	2015	26050253	Yes
927	2445	2445.0	54.0	54.0	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
928	2445	2445.0	65.0	65.0	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
929	2431	2431.0	128.9	128.9	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
930	2430	2430.0	67.5	67.5	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
931	4860	2430.0	108.9	54.5	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
932	2430	2430.0	105.5	105.5	International classification of sleep disorders-third edition: highlights and modifications.	Michael J Sateia	Chest	2014	25367475	No
933	4853	2426.5	174.2	87.1	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
934	4852	2426.0	127.1	63.5	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
935	4850	2425.0	135.9	68.0	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
936	2422	2422.0	51.9	51.9	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
937	2420	2420.0	55.8	55.8	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
938	2418	2418.0	49.0	49.0	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
939	4831	2415.5	175.4	87.7	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
940	2415	2415.0	63.0	63.0	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
941	4829	2414.5	97.4	48.7	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
942	2413	2413.0	0.0	0.0	Muscle structure and theories of contraction.	A F HUXLEY	Prog Biophys Biophys Chem	1957	13485191	Yes
943	7234	2411.3	211.9	70.6	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
944	2411	2411.0	80.6	80.6	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jobsis	Science	1977	929199	Yes
945	2411	2411.0	49.5	49.5	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
946	2411	2411.0	51.8	51.8	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
947	2410	2410.0	54.7	54.7	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
948	2409	2409.0	74.8	74.8	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
949	2409	2409.0	49.0	49.0	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
950	2407	2407.0	142.8	142.8	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
951	4812	2406.0	90.9	45.5	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massague	Cell	2003	12809600	No
952	7208	2402.7	205.1	68.4	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
953	4804	2402.0	210.1	105.0	Making sense of Cronbach's alpha.	Mohsen Tavakol, Reg Dennick	Int J Med Educ	2011	28029643	No
954	4804	2402.0	249.3	124.7	OrthoFinder: phylogenetic orthology inference for comparative genomics.	David M Emms, Steven Kelly	Genome Biol	2019	31727128	Yes
955	7204	2401.3	69.7	23.2	On The Nature Of Allosteric Transitions: A Plausible Model.	J MONOD, J WYMAN, J P CHANGEUX	J Mol Biol	1965	14343300	Yes
956	4799	2399.5	119.5	59.8	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
957	4796	2398.0	125.2	62.6	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
958	9590	2397.5	306.4	76.6	Common method biases in behavioral research: a critical review of the literature and recommended remedies.	Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff	J Appl Psychol	2003	14516251	No
959	4792	2396.0	132.9	66.5	Software survey: VOSviewer, a computer program for bibliometric mapping.	Nees Jan van Eck, Ludo Waltman	Scientometrics	2010	20585380	Yes
960	2394	2394.0	68.1	68.1	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
961	4785	2392.5	117.8	58.9	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
962	2388	2388.0	56.1	56.1	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
963	4770	2385.0	97.1	48.5	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
964	2383	2383.0	97.4	97.4	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
965	7146	2382.0	193.1	64.4	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
966	4760	2380.0	89.3	44.6	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
967	2380	2380.0	92.4	92.4	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
968	4755	2377.5	169.3	84.7	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
969	9509	2377.2	218.1	54.5	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
970	2376	2376.0	45.7	45.7	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
971	4745	2372.5	154.9	77.5	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
972	4736	2368.0	118.2	59.1	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
973	2366	2366.0	78.5	78.5	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
974	2363	2363.0	42.8	42.8	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
975	4724	2362.0	102.6	51.3	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
976	2356	2356.0	40.0	40.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
977	4712	2356.0	116.5	58.2	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
978	2353	2353.0	51.7	51.7	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
979	4705	2352.5	77.8	38.9	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
980	4701	2350.5	88.4	44.2	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
981	2350	2350.0	70.4	70.4	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
982	4697	2348.5	111.7	55.9	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
983	2348	2348.0	57.9	57.9	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
984	4695	2347.5	192.4	96.2	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
985	2346	2346.0	62.6	62.6	The episodic buffer: a new component of working memory?	A Baddeley	Trends Cogn Sci	2000	11058819	Yes
986	2346	2346.0	79.4	79.4	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
987	4690	2345.0	165.5	82.8	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
988	2343	2343.0	66.0	66.0	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
989	2342	2342.0	72.1	72.1	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
990	2342	2342.0	68.8	68.8	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
991	2341	2341.0	48.9	48.9	Theta oscillations in the hippocampus.	Gyorgy Buzsaki	Neuron	2002	11832222	No
992	2338	2338.0	55.9	55.9	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
993	2337	2337.0	52.3	52.3	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
994	2336	2336.0	43.3	43.3	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
995	4670	2335.0	102.3	51.1	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
996	4668	2334.0	76.7	38.4	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
997	2333	2333.0	57.5	57.5	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
998	4664	2332.0	115.0	57.5	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
999	6996	2332.0	140.9	47.0	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1000	2331	2331.0	84.2	84.2	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
1001	2328	2328.0	86.3	86.3	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
1002	4655	2327.5	192.1	96.0	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1003	4649	2324.5	146.0	73.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1004	2324	2324.0	71.7	71.7	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
1005	2323	2323.0	64.2	64.2	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
1006	2322	2322.0	67.9	67.9	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1007	2321	2321.0	61.6	61.6	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1008	4639	2319.5	127.6	63.8	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
1009	4634	2317.0	131.0	65.5	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1010	4633	2316.5	85.7	42.9	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1011	6947	2315.7	264.5	88.2	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
1012	4623	2311.5	91.3	45.6	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
1013	2308	2308.0	55.0	55.0	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1014	2308	2308.0	55.5	55.5	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1015	2308	2308.0	55.5	55.5	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
1016	4611	2305.5	68.9	34.5	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
1017	25359	2305.4	608.0	55.3	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1018	2301	2301.0	56.6	56.6	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
1019	4598	2299.0	109.4	54.7	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
1020	6894	2298.0	157.3	52.4	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1021	2297	2297.0	46.0	46.0	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1022	2297	2297.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H PENNES	J Appl Physiol	1948	18887578	Yes
1023	4589	2294.5	123.5	61.8	Extended-connectivity fingerprints.	David Rogers, Mathew Hahn	J Chem Inf Model	2010	20426451	Yes
1024	4588	2294.0	239.0	119.5	ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R.	Emmanuel Paradis, Klaus Schliep	Bioinformatics	2019	30016406	Yes
1025	2292	2292.0	69.3	69.3	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
1026	2292	2292.0	91.8	91.8	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
1027	2292	2292.0	56.9	56.9	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1028	2292	2292.0	74.5	74.5	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1029	2291	2291.0	68.7	68.7	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
1030	4581	2290.5	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B SCOVILLE, B MILNER	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
1031	2290	2290.0	49.3	49.3	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1032	2287	2287.0	56.7	56.7	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
1033	2287	2287.0	60.7	60.7	Hybrid porous solids: past, present, future.	Gerard Ferey	Chem Soc Rev	2008	18197340	Yes
1034	4572	2286.0	174.6	87.3	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
1035	4570	2285.0	110.1	55.0	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1036	2284	2284.0	75.9	75.9	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
1037	2284	2284.0	112.8	112.8	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1038	6847	2282.3	221.0	73.7	Complex heatmaps reveal patterns and correlations in multidimensional genomic data.	Zuguang Gu, Roland Eils, Matthias Schlesner	Bioinformatics	2016	27207943	Yes
1039	2282	2282.0	63.7	63.7	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1040	2281	2281.0	45.0	45.0	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
1041	2281	2281.0	65.5	65.5	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1042	4559	2279.5	121.8	60.9	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1043	2279	2279.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A CLAUSS	Acta Haematol	1957	13434757	Yes
1044	2279	2279.0	80.4	80.4	Macrophage Polarization.	Peter J Murray	Annu Rev Physiol	2017	27813830	No
1045	4553	2276.5	86.9	43.5	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1046	2276	2276.0	47.4	47.4	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
1047	2274	2274.0	51.7	51.7	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1048	2268	2268.0	53.0	53.0	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1049	2268	2268.0	50.1	50.1	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
1050	2268	2268.0	48.5	48.5	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1051	4531	2265.5	89.3	44.6	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
1052	2262	2262.0	62.3	62.3	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
1053	2260	2260.0	61.7	61.7	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
1054	2259	2259.0	139.5	139.5	Application of a microtechnique to viral serological investigations.	J L SEVER	J Immunol	1962	13910995	Yes
1055	2259	2259.0	96.0	96.0	Hydrogel: Preparation, characterization, and applications: A review.	Enas M Ahmed	J Adv Res	2015	25750745	No
1056	4508	2254.0	128.6	64.3	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
1057	4507	2253.5	38.5	19.2	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
1058	2252	2252.0	96.0	96.0	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1059	2251	2251.0	52.9	52.9	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
1060	6751	2250.3	182.2	60.7	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdottir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1061	13499	2249.8	297.8	49.6	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
1062	4498	2249.0	102.1	51.0	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
1063	6746	2248.7	209.3	69.8	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman,	Hepatology	2011	21374666	No
1064	4497	2248.5	94.5	47.2	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1065	2248	2248.0	48.6	48.6	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
1066	2247	2247.0	116.1	116.1	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
1067	4494	2247.0	164.3	82.2	Sex differences in immune responses.	Sabra L Klein, Katie L Flanagan	Nat Rev Immunol	2016	27546235	No
1068	2246	2246.0	71.7	71.7	Modeling Development and Disease with Organoids.	Hans Clevers	Cell	2016	27315476	No
1069	4491	2245.5	102.3	51.1	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
1070	2245	2245.0	57.8	57.8	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
1071	2244	2244.0	76.7	76.7	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
1072	2244	2244.0	54.1	54.1	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gokhan S Hotamisligil	Cell	2010	20303879	No
1073	2243	2243.0	60.8	60.8	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
1074	4486	2243.0	140.5	70.2	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
1075	2243	2243.0	54.8	54.8	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
1076	8966	2241.5	344.4	86.1	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramon Doallo, David Posada	Nat Methods	2012	22847109	Yes
1077	17918	2239.8	500.4	62.5	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
1078	2235	2235.0	65.9	65.9	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
1079	2229	2229.0	52.0	52.0	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
1080	2228	2228.0	110.5	110.5	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
1081	2226	2226.0	72.7	72.7	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
1082	4452	2226.0	118.8	59.4	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1083	4449	2224.5	97.8	48.9	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
1084	4448	2224.0	84.0	42.0	Network biology: understanding the cell's functional organization.	Albert-Laszlo Barabasi, Zoltan N Oltvai	Nat Rev Genet	2004	14735121	No
1085	4447	2223.5	98.7	49.4	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
1086	2223	2223.0	52.1	52.1	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
1087	2223	2223.0	76.7	76.7	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
1088	2223	2223.0	49.3	49.3	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1089	2221	2221.0	59.8	59.8	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1090	4437	2218.5	94.8	47.4	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1091	4437	2218.5	186.4	93.2	A simple practice guide for dose conversion between animals and human.	Anroop B Nair, Shery Jacob	J Basic Clin Pharm	2016	27057123	No
1092	2218	2218.0	91.6	91.6	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
1093	2218	2218.0	48.3	48.3	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
1094	4436	2218.0	164.9	82.5	Parkinson's disease.	Lorraine V Kalia, Anthony E Lang	Lancet	2015	25904081	No
1095	2212	2212.0	67.9	67.9	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1096	4424	2212.0	172.6	86.3	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
1097	2211	2211.0	78.6	78.6	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
1098	2209	2209.0	69.7	69.7	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Loe	J Periodontol	1967	5237684	Yes
1099	2209	2209.0	51.5	51.5	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1100	4417	2208.5	154.4	77.2	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1101	2208	2208.0	67.5	67.5	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
1102	2205	2205.0	56.6	56.6	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
1103	2205	2205.0	82.8	82.8	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
1104	2201	2201.0	48.6	48.6	Chemokines.	B J Rollins	Blood	1997	9242519	No
1105	2198	2198.0	86.0	86.0	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1106	6594	2198.0	189.2	63.1	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
1107	2197	2197.0	52.2	52.2	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1108	2197	2197.0	184.8	184.8	Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.	Brent R Stockwell	Cell	2022	35803244	No
1109	6588	2196.0	166.3	55.4	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1110	4386	2193.0	80.6	40.3	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
1111	4385	2192.5	147.0	73.5	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
1112	4375	2187.5	99.9	50.0	Neuronal oscillations in cortical networks.	Gyorgy Buzsaki, Andreas Draguhn	Science	2004	15218136	No
1113	10935	2187.0	339.2	67.8	The hallmarks of aging.	Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
1114	2184	2184.0	59.9	59.9	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1115	2183	2183.0	50.3	50.3	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1116	8729	2182.2	202.4	50.6	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1117	2182	2182.0	39.1	39.1	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
1118	4360	2180.0	132.4	66.2	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1119	2178	2178.0	59.5	59.5	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1120	2178	2178.0	58.7	58.7	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1121	8712	2178.0	206.4	51.6	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1122	2178	2178.0	50.9	50.9	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1123	4350	2175.0	82.8	41.4	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1124	2174	2174.0	46.2	46.2	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1125	8694	2173.5	282.0	70.5	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1126	15212	2173.1	429.5	61.4	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
1127	2173	2173.0	64.6	64.6	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
1128	4346	2173.0	103.4	51.7	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1129	4342	2171.0	189.1	94.5	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1130	2171	2171.0	81.1	81.1	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1131	4341	2170.5	94.7	47.4	Liver fibrosis.	Ramon Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1132	4340	2170.0	86.6	43.3	'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?	George Davey Smith, Shah Ebrahim	Int J Epidemiol	2003	12689998	No
1133	2169	2169.0	46.5	46.5	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
1134	2167	2167.0	66.4	66.4	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1135	2163	2163.0	41.4	41.4	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
1136	2162	2162.0	54.8	54.8	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1137	4323	2161.5	92.0	46.0	ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking.	Matthew D Wilkerson, D Neil Hayes	Bioinformatics	2010	20427518	Yes
1138	4320	2160.0	124.2	62.1	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1139	2159	2159.0	51.1	51.1	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1140	2159	2159.0	82.0	82.0	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
1141	4317	2158.5	101.4	50.7	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
1142	2158	2158.0	42.6	42.6	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
1143	4316	2158.0	35.8	17.9	Genetic regulatory mechanisms in the synthesis of proteins.	F JACOB, J MONOD	J Mol Biol	1961	13718526	Yes
1144	6473	2157.7	206.3	68.8	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1145	2157	2157.0	42.9	42.9	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
1146	2157	2157.0	40.7	40.7	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1147	4309	2154.5	104.8	52.4	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1148	2154	2154.0	0.0	0.0	On respiratory impairment in cancer cells.	O WARBURG	Science	1956	13351639	Yes
1149	2154	2154.0	74.6	74.6	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
1150	6462	2154.0	204.8	68.3	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1151	2153	2153.0	30.6	30.6	Sedimentation Studies Of The Size And Shape Of Dna.	F W STUDIER	J Mol Biol	1965	14290352	Yes
1152	2153	2153.0	66.4	66.4	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1153	2151	2151.0	44.2	44.2	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1154	2148	2148.0	42.1	42.1	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1155	2146	2146.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z DISCHE	J Biol Chem	1947	20281638	Yes
1156	6437	2145.7	129.5	43.2	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
1157	6432	2144.0	146.4	48.8	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wuthrich	J Mol Graph	1996	8744573	Yes
1158	4287	2143.5	122.1	61.0	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
1159	4286	2143.0	71.4	35.7	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H VENABLE, R COGGESHALL	J Cell Biol	1965	14287192	Yes
1160	2141	2141.0	43.1	43.1	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1161	2141	2141.0	40.9	40.9	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1162	4279	2139.5	143.2	71.6	The Emerging Hallmarks of Cancer Metabolism.	Natalya N Pavlova, Craig B Thompson	Cell Metab	2016	26771115	No
1163	6418	2139.3	267.4	89.1	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
1164	2139	2139.0	64.4	64.4	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
1165	4278	2139.0	120.8	60.4	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1166	4278	2139.0	274.1	137.1	WHO Declares COVID-19 a Pandemic.	Domenico Cucinotta, Maurizio Vanelli	Acta Biomed	2020	32191675	Yes
1167	2138	2138.0	64.4	64.4	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1168	4273	2136.5	110.8	55.4	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1169	4273	2136.5	181.8	90.9	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1170	8540	2135.0	316.5	79.1	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerstrom	Br J Addict	1991	1932883	Yes
1171	2134	2134.0	66.1	66.1	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1172	4267	2133.5	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F BEERS, I W SIZER	J Biol Chem	1952	14938361	Yes
1173	4267	2133.5	186.2	93.1	Sensitivity Analysis in Observational Research: Introducing the E-Value.	Tyler J VanderWeele, Peng Ding	Ann Intern Med	2017	28693043	Yes
1174	2133	2133.0	44.8	44.8	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1175	6392	2130.7	115.8	38.6	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
1176	4261	2130.5	118.8	59.4	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1177	14911	2130.1	322.7	46.1	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1178	4259	2129.5	225.0	112.5	Interactive Tree Of Life (iTOL) v4: recent updates and new developments.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2019	30931475	Yes
1179	4258	2129.0	153.2	76.6	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1180	4257	2128.5	150.5	75.2	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1181	6380	2126.7	212.2	70.7	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
1182	2125	2125.0	81.4	81.4	Machine Learning in Medicine.	Rahul C Deo	Circulation	2015	26572668	No
1183	6373	2124.3	205.8	68.6	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1184	4247	2123.5	105.6	52.8	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
1185	4246	2123.0	121.5	60.8	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
1186	2122	2122.0	98.7	98.7	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1187	2122	2122.0	44.1	44.1	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
1188	4243	2121.5	148.7	74.3	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
1189	2121	2121.0	34.4	34.4	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D AMINOFF	Biochem J	1961	13860975	Yes
1190	2118	2118.0	83.1	83.1	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
1191	4236	2118.0	121.5	60.8	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
1192	2115	2115.0	47.4	47.4	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1193	4227	2113.5	91.1	45.5	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
1194	4227	2113.5	82.3	41.1	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
1195	4222	2111.0	82.5	41.2	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
1196	2111	2111.0	49.3	49.3	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
1197	2110	2110.0	60.1	60.1	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
1198	2109	2109.0	40.8	40.8	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1199	2108	2108.0	47.4	47.4	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1200	6323	2107.7	182.4	60.8	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
1201	4215	2107.5	141.3	70.7	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	Yes
1202	2107	2107.0	0.0	0.0	Cognitive maps in rats and men.	E C TOLMAN	Psychol Rev	1948	18870876	Yes
1203	2106	2106.0	66.2	66.2	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1204	4208	2104.0	132.2	66.1	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1205	4206	2103.0	105.6	52.8	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
1206	4206	2103.0	80.4	40.2	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1207	2102	2102.0	74.6	74.6	AliView: a fast and lightweight alignment viewer and editor for large datasets.	Anders Larsson	Bioinformatics	2014	25095880	Yes
1208	2101	2101.0	40.6	40.6	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
1209	8403	2100.8	270.1	67.5	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1210	2099	2099.0	50.7	50.7	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1211	2098	2098.0	42.8	42.8	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1212	2097	2097.0	47.3	47.3	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1213	16774	2096.8	394.9	49.4	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1214	14676	2096.6	417.6	59.7	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke,	Lancet	2007	18064739	Yes
1215	4191	2095.5	101.7	50.9	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1216	2095	2095.0	74.6	74.6	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
1217	2095	2095.0	52.3	52.3	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1218	6284	2094.7	158.4	52.8	Fast model-based estimation of ancestry in unrelated individuals.	David H Alexander, John Novembre, Kenneth Lange	Genome Res	2009	19648217	Yes
1219	14658	2094.0	321.3	45.9	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1220	2093	2093.0	65.2	65.2	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1221	14649	2092.7	388.6	55.5	BLAST+: architecture and applications.	Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden	BMC Bioinformatics	2009	20003500	Yes
1222	2092	2092.0	57.7	57.7	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1223	4184	2092.0	128.2	64.1	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1224	4183	2091.5	288.5	144.2	Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.	David J Newman, Gordon M Cragg	J Nat Prod	2020	32162523	No
1225	4177	2088.5	100.0	50.0	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1226	8353	2088.2	373.2	93.3	Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range.	Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong	BMC Med Res Methodol	2014	25524443	Yes
1227	2088	2088.0	56.5	56.5	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
1228	2087	2087.0	39.9	39.9	Method For Assay Of Intestinal Disaccharidases.	A DAHLQVIST	Anal Biochem	1964	14106916	Yes
1229	6256	2085.3	254.7	84.9	Shedding light on the cell biology of extracellular vesicles.	Guillaume van Niel, Gisela D'Angelo, Graca Raposo	Nat Rev Mol Cell Biol	2018	29339798	No
1230	2084	2084.0	43.1	43.1	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1231	2083	2083.0	39.6	39.6	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1232	2083	2083.0	38.3	38.3	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1233	2083	2083.0	76.9	76.9	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
1234	2080	2080.0	49.1	49.1	Negative refraction makes a perfect lens	J B Pendry	Phys Rev Lett	2000	11041972	Yes
1235	4158	2079.0	110.7	55.4	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1236	2079	2079.0	59.3	59.3	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1237	4155	2077.5	79.5	39.8	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelieres	J Microsc	2006	17210054	Yes
1238	6226	2075.3	198.4	66.1	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1239	2075	2075.0	47.8	47.8	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
1240	2075	2075.0	52.3	52.3	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
1241	2073	2073.0	36.3	36.3	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C SKOU	Physiol Rev	1965	14337569	No
1242	2072	2072.0	57.9	57.9	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1243	2070	2070.0	51.9	51.9	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1244	2068	2068.0	42.3	42.3	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1245	4135	2067.5	89.3	44.6	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1246	2066	2066.0	39.9	39.9	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1247	2065	2065.0	63.1	63.1	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1248	2065	2065.0	53.2	53.2	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1249	4128	2064.0	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R DULBECCO, M VOGT	J Exp Med	1954	13130792	Yes
1250	4127	2063.5	110.2	55.1	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1251	2063	2063.0	46.5	46.5	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1252	6187	2062.3	228.8	76.3	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1253	4123	2061.5	96.0	48.0	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
1254	2061	2061.0	18.6	18.6	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W CLELAND	Biochim Biophys Acta	1963	14021667	Yes
1255	8243	2060.8	224.9	56.2	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1256	6172	2057.3	266.7	88.9	Radiomics: Images Are More than Pictures, They Are Data.	Robert J Gillies, Paul E Kinahan, Hedvig Hricak	Radiology	2016	26579733	Yes
1257	2056	2056.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A SHOLL	J Anat	1953	13117757	Yes
1258	2056	2056.0	98.5	98.5	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V NEEL	Am J Hum Genet	1962	13937884	Yes
1259	4111	2055.5	85.4	42.7	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1260	2055	2055.0	67.6	67.6	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1261	2054	2054.0	83.9	83.9	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1262	8214	2053.5	272.0	68.0	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
1263	2053	2053.0	34.7	34.7	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
1264	2053	2053.0	23.8	23.8	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W LITTLEFIELD	Science	1964	14168277	Yes
1265	2053	2053.0	52.6	52.6	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1266	2052	2052.0	46.1	46.1	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1267	2050	2050.0	63.5	63.5	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1268	4097	2048.5	125.2	62.6	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1269	2047	2047.0	58.8	58.8	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1270	2047	2047.0	59.1	59.1	Inhibited spontaneous emission in solid-state physics and electronics.	E Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1271	2046	2046.0	55.7	55.7	Introduction and General Overview of Cyclodextrin Chemistry.	Jozsef Szejtli	Chem Rev	1998	11848947	Yes
1272	4092	2046.0	100.2	50.1	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
1273	4090	2045.0	139.3	69.7	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1274	4090	2045.0	110.4	55.2	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1275	4087	2043.5	119.8	59.9	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
1276	18381	2042.3	568.5	63.2	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	, D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
1277	2042	2042.0	34.7	34.7	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1278	4083	2041.5	159.9	80.0	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1279	4081	2040.5	102.3	51.1	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	S Nie, S R Emory	Science	1997	9027306	Yes
1280	4081	2040.5	90.3	45.1	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1281	12241	2040.2	278.1	46.4	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
1282	2040	2040.0	51.9	51.9	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1283	2039	2039.0	64.1	64.1	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
1284	2038	2038.0	60.2	60.2	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1285	2038	2038.0	83.9	83.9	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1286	2038	2038.0	50.7	50.7	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1287	4075	2037.5	92.5	46.2	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1288	2037	2037.0	60.3	60.3	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1289	2036	2036.0	47.2	47.2	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1290	2036	2036.0	43.2	43.2	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1291	4069	2034.5	78.8	39.4	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
1292	4068	2034.0	123.5	61.8	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
1293	10164	2032.8	469.4	93.9	ModelFinder: fast model selection for accurate phylogenetic estimates.	Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin	Nat Methods	2017	28481363	Yes
1294	4064	2032.0	139.3	69.7	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1295	4062	2031.0	97.8	48.9	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1296	2031	2031.0	71.8	71.8	The global burden of IBD: from 2015 to 2025.	Gilaad G Kaplan	Nat Rev Gastroenterol Hepatol	2015	26323879	No
1297	4061	2030.5	103.3	51.6	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1298	6090	2030.0	299.0	99.7	Production, use, and fate of all plastics ever made.	Roland Geyer, Jenna R Jambeck, Kara Lavender Law	Sci Adv	2017	28776036	Yes
1299	2029	2029.0	38.2	38.2	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1300	2029	2029.0	53.2	53.2	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
1301	2028	2028.0	77.1	77.1	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1302	2028	2028.0	52.2	52.2	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1303	2027	2027.0	38.9	38.9	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1304	2025	2025.0	36.9	36.9	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
1305	2025	2025.0	50.6	50.6	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1306	2025	2025.0	76.2	76.2	Periodontitis: from microbial immune subversion to systemic inflammation.	George Hajishengallis	Nat Rev Immunol	2015	25534621	No
1307	4047	2023.5	91.8	45.9	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1308	2023	2023.0	52.6	52.6	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
1309	2023	2023.0	47.0	47.0	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
1310	2022	2022.0	59.1	59.1	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
1311	8078	2019.5	186.2	46.5	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1312	4037	2018.5	111.8	55.9	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1313	2018	2018.0	70.1	70.1	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1314	2016	2016.0	88.4	88.4	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1315	4032	2016.0	97.9	49.0	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1316	2014	2014.0	0.0	0.0	Antigen-antibody reactions in gels.	O OUCHTERLONY	Acta Pathol Microbiol Scand	1949	18143039	Yes
1317	4027	2013.5	85.6	42.8	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1318	2012	2012.0	41.5	41.5	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1319	2010	2010.0	38.1	38.1	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
1320	6030	2010.0	173.6	57.9	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
1321	2009	2009.0	39.7	39.7	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1322	2009	2009.0	45.0	45.0	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1323	2009	2009.0	43.3	43.3	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1324	2008	2008.0	41.1	41.1	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
1325	4015	2007.5	103.4	51.7	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1326	4014	2007.0	122.2	61.1	Efficient pseudopotentials for plane-wave calculations.	N Troullier, J L Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1327	6014	2004.7	352.4	117.5	Sample Size in Qualitative Interview Studies: Guided by Information Power.	Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora	Qual Health Res	2016	26613970	Yes
1328	12026	2004.3	341.6	56.9	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1329	4008	2004.0	86.7	43.4	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
1330	12020	2003.3	341.5	56.9	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1331	2003	2003.0	43.6	43.6	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1332	4006	2003.0	107.4	53.7	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1333	2001	2001.0	22.6	22.6	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1334	2000	2000.0	54.8	54.8	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1335	2000	2000.0	51.3	51.3	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1336	4000	2000.0	142.9	71.5	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
1337	3998	1999.0	94.2	47.1	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1338	1999	1999.0	59.7	59.7	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1339	1999	1999.0	51.8	51.8	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1340	15992	1999.0	510.4	63.8	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann,	BMJ	2008	18436948	Yes
1341	3997	1998.5	115.0	57.5	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1342	1997	1997.0	63.3	63.3	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1343	1996	1996.0	52.5	52.5	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1344	3991	1995.5	107.6	53.8	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1345	7977	1994.2	308.6	77.2	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1346	1993	1993.0	43.7	43.7	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1347	1993	1993.0	40.3	40.3	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
1348	1993	1993.0	34.6	34.6	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1349	1993	1993.0	56.3	56.3	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
1350	1992	1992.0	52.7	52.7	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1351	1992	1992.0	48.8	48.8	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1352	3982	1991.0	89.5	44.8	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schuttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1353	7963	1990.8	208.2	52.0	Image quality assessment: from error visibility to structural similarity.	Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli	IEEE Trans Image Process	2004	15376593	Yes
1354	1990	1990.0	41.8	41.8	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1355	1990	1990.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
1356	9949	1989.8	224.8	45.0	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1357	3978	1989.0	59.6	29.8	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R MORRISON, L M SMITH	J Lipid Res	1964	14221106	Yes
1358	1988	1988.0	40.1	40.1	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1359	1987	1987.0	16.0	16.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1360	5958	1986.0	330.2	110.1	An interactive web-based dashboard to track COVID-19 in real time.	Ensheng Dong, Hongru Du, Lauren Gardner	Lancet Infect Dis	2020	32087114	Yes
1361	5955	1985.0	121.3	40.4	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
1362	1984	1984.0	57.7	57.7	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1363	3965	1982.5	87.1	43.5	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1364	1982	1982.0	70.5	70.5	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1365	3964	1982.0	132.9	66.5	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1366	1980	1980.0	56.6	56.6	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1367	1979	1979.0	46.2	46.2	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1368	1978	1978.0	39.1	39.1	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1369	1978	1978.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R STEELE	Ann N Y Acad Sci	1959	13833973	Yes
1370	3955	1977.5	94.6	47.3	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1371	3955	1977.5	77.6	38.8	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
1372	1977	1977.0	38.7	38.7	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1373	1976	1976.0	48.6	48.6	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1374	3949	1974.5	85.5	42.8	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1375	1974	1974.0	55.3	55.3	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1376	1974	1974.0	76.6	76.6	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1377	5921	1973.7	149.0	49.7	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1378	5919	1973.0	194.9	65.0	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1379	1973	1973.0	0.0	0.0	On estimating the relation between blood group and disease.	B WOOLF	Ann Hum Genet	1955	14388528	Yes
1380	1972	1972.0	66.9	66.9	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1381	1971	1971.0	63.7	63.7	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1382	5912	1970.7	105.8	35.3	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1383	3941	1970.5	96.1	48.0	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1384	7879	1969.8	327.3	81.8	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1385	1969	1969.0	57.9	57.9	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1386	3936	1968.0	122.6	61.3	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1387	1968	1968.0	58.0	58.0	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
1388	1968	1968.0	77.8	77.8	Oxidative stress: a concept in redox biology and medicine.	Helmut Sies	Redox Biol	2015	25588755	No
1389	3934	1967.0	79.8	39.9	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1390	3932	1966.0	128.4	64.2	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
1391	3931	1965.5	144.1	72.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1392	1965	1965.0	55.6	55.6	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1393	1965	1965.0	40.6	40.6	The etiology of chondromalacia patellae.	R E OUTERBRIDGE	J Bone Joint Surg Br	1961	14038135	Yes
1394	9817	1963.4	424.6	84.9	Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype.	Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg	Nat Biotechnol	2019	31375807	Yes
1395	1963	1963.0	70.7	70.7	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1396	1963	1963.0	64.9	64.9	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1397	1961	1961.0	54.5	54.5	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1398	1960	1960.0	55.7	55.7	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1399	1960	1960.0	62.2	62.2	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1400	1960	1960.0	42.1	42.1	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1401	1960	1960.0	42.4	42.4	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1402	3920	1960.0	126.2	63.1	Elements of cancer immunity and the cancer-immune set point.	Daniel S Chen, Ira Mellman	Nature	2017	28102259	No
1403	1957	1957.0	45.9	45.9	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1404	1957	1957.0	44.6	44.6	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1405	1956	1956.0	57.2	57.2	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1406	3905	1952.5	137.1	68.5	Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.	Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon	Brain Connect	2012	22642651	Yes
1407	3905	1952.5	107.0	53.5	CTFFIND4: Fast and accurate defocus estimation from electron micrographs.	Alexis Rohou, Nikolaus Grigorieff	J Struct Biol	2015	26278980	Yes
1408	1952	1952.0	65.1	65.1	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1409	1951	1951.0	42.6	42.6	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1410	3902	1951.0	88.1	44.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1411	3902	1951.0	89.3	44.6	Decision curve analysis: a novel method for evaluating prediction models.	Andrew J Vickers, Elena B Elkin	Med Decis Making	2006	17099194	Yes
1412	1951	1951.0	94.5	94.5	Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead.	Cynthia Rudin	Nat Mach Intell	2019	35603010	Yes
1413	3901	1950.5	73.5	36.8	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1414	1950	1950.0	56.6	56.6	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1415	3899	1949.5	87.5	43.8	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1416	25341	1949.3	940.0	72.3	Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.	Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm,	Genet Med	2015	25741868	Yes
1417	1949	1949.0	77.8	77.8	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1418	1949	1949.0	45.8	45.8	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1419	1949	1949.0	41.0	41.0	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1420	1949	1949.0	92.1	92.1	DLS and zeta potential - What they are and what they are not?	Sourav Bhattacharjee	J Control Release	2016	27297779	No
1421	3897	1948.5	80.2	40.1	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1422	1948	1948.0	42.7	42.7	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1423	3895	1947.5	65.5	32.8	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1424	3895	1947.5	109.6	54.8	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
1425	1944	1944.0	51.9	51.9	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1426	5831	1943.7	119.1	39.7	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1427	3887	1943.5	102.9	51.5	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1428	3886	1943.0	69.3	34.6	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1429	1943	1943.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V BOYDEN	J Exp Med	1951	14803635	Yes
1430	1939	1939.0	53.6	53.6	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1431	13564	1937.7	472.8	67.5	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1432	1937	1937.0	63.6	63.6	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1433	3874	1937.0	102.7	51.4	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1434	1936	1936.0	76.8	76.8	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1435	1936	1936.0	33.8	33.8	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1436	5808	1936.0	152.7	50.9	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Rohl	Mol Biol Evol	1999	10331250	Yes
1437	3871	1935.5	102.8	51.4	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1438	1933	1933.0	50.3	50.3	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1439	1932	1932.0	61.1	61.1	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1440	1931	1931.0	46.7	46.7	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1441	1931	1931.0	51.3	51.3	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1442	1931	1931.0	68.2	68.2	Antibiotics in the aquatic environment--a review--part I.	Klaus Kummerer	Chemosphere	2009	19185900	No
1443	1929	1929.0	41.4	41.4	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1444	7705	1926.2	187.8	47.0	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1445	1925	1925.0	46.7	46.7	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1446	1925	1925.0	126.6	126.6	The changing landscape of atherosclerosis.	Peter Libby	Nature	2021	33883728	No
1447	3848	1924.0	194.6	97.3	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1448	1924	1924.0	52.0	52.0	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1449	5770	1923.3	125.4	41.8	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1450	1922	1922.0	77.6	77.6	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1451	1921	1921.0	42.1	42.1	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1452	5756	1918.7	169.1	56.4	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1453	3837	1918.5	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J VOGEL, D M BONNER	J Biol Chem	1956	13278318	Yes
1454	3835	1917.5	127.7	63.9	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1455	1917	1917.0	46.7	46.7	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1456	1917	1917.0	65.5	65.5	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1457	1917	1917.0	50.2	50.2	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
1458	1916	1916.0	39.5	39.5	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1459	7656	1914.0	213.3	53.3	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1460	3827	1913.5	114.8	57.4	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1461	1913	1913.0	50.6	50.6	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1462	5737	1912.3	117.2	39.1	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	J H Zhang, T D Chung, K R Oldenburg	J Biomol Screen	1999	10838414	Yes
1463	1911	1911.0	100.1	100.1	Information bias in health research: definition, pitfalls, and adjustment methods.	Alaa Althubaiti	J Multidiscip Healthc	2016	27217764	No
1464	1910	1910.0	53.5	53.5	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1465	1910	1910.0	34.7	34.7	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1466	3818	1909.0	84.9	42.5	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1467	5727	1909.0	160.0	53.3	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallieres, C M. Morin	Sleep Med	2001	11438246	Yes
1468	1908	1908.0	43.0	43.0	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
1469	5723	1907.7	343.4	114.5	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1470	5722	1907.3	383.2	127.7	Ferroptosis: mechanisms, biology and role in disease.	Xuejun Jiang, Brent R Stockwell, Marcus Conrad	Nat Rev Mol Cell Biol	2021	33495651	No
1471	1907	1907.0	51.4	51.4	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1472	3812	1906.0	100.2	50.1	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1473	3812	1906.0	88.4	44.2	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1474	3812	1906.0	121.9	61.0	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1475	1905	1905.0	41.1	41.1	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1476	1903	1903.0	19.9	19.9	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1477	1902	1902.0	64.5	64.5	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1478	1901	1901.0	87.6	87.6	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1479	1901	1901.0	43.4	43.4	Tricine-SDS-PAGE.	Hermann Schagger	Nat Protoc	2006	17406207	Yes
1480	1901	1901.0	50.4	50.4	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1481	1900	1900.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H HIRS	J Biol Chem	1956	13319283	Yes
1482	3798	1899.0	89.6	44.8	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1483	1899	1899.0	46.8	46.8	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1484	1896	1896.0	37.5	37.5	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1485	7581	1895.2	283.4	70.8	QUAST: quality assessment tool for genome assemblies.	Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler	Bioinformatics	2013	23422339	Yes
1486	1894	1894.0	37.5	37.5	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1487	3788	1894.0	87.2	43.6	Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.	Felix Krueger, Simon R Andrews	Bioinformatics	2011	21493656	Yes
1488	7572	1893.0	251.6	62.9	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1489	3786	1893.0	135.2	67.6	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1490	5678	1892.7	125.1	41.7	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1491	1892	1892.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1492	3783	1891.5	112.0	56.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1493	9451	1890.2	214.1	42.8	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1494	1890	1890.0	82.7	82.7	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1495	1889	1889.0	34.0	34.0	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1496	9445	1889.0	330.4	66.1	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1497	1888	1888.0	60.9	60.9	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1498	5664	1888.0	173.2	57.7	SCANPY: large-scale single-cell gene expression data analysis.	F Alexander Wolf, Philipp Angerer, Fabian J Theis	Genome Biol	2018	29409532	Yes
1499	1886	1886.0	58.8	58.8	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1500	1886	1886.0	44.6	44.6	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1501	1885	1885.0	47.8	47.8	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1502	1884	1884.0	36.6	36.6	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1503	3767	1883.5	77.5	38.8	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1504	1883	1883.0	43.6	43.6	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1505	3766	1883.0	76.6	38.3	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1506	1883	1883.0	53.9	53.9	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
1507	1883	1883.0	57.1	57.1	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1508	1882	1882.0	85.9	85.9	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1509	3762	1881.0	190.6	95.3	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1510	1881	1881.0	37.4	37.4	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1511	1880	1880.0	54.6	54.6	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1512	1880	1880.0	35.0	35.0	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1513	1877	1877.0	54.0	54.0	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1514	3753	1876.5	100.6	50.3	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1515	1875	1875.0	55.7	55.7	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
1516	1875	1875.0	36.1	36.1	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1517	1874	1874.0	33.7	33.7	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1518	1874	1874.0	42.2	42.2	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1519	7493	1873.2	179.6	44.9	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1520	1873	1873.0	46.2	46.2	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1521	5619	1873.0	144.5	48.2	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1522	1873	1873.0	38.9	38.9	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1523	1873	1873.0	44.2	44.2	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
1524	1872	1872.0	44.7	44.7	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1525	3743	1871.5	77.7	38.9	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1526	5614	1871.3	139.2	46.4	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1527	3742	1871.0	120.6	60.3	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1528	3741	1870.5	104.0	52.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1529	1870	1870.0	70.5	70.5	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1530	1870	1870.0	42.4	42.4	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1531	11218	1869.7	297.6	49.6	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
1532	1869	1869.0	38.8	38.8	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1533	1868	1868.0	66.2	66.2	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1534	1868	1868.0	37.9	37.9	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1535	1866	1866.0	42.4	42.4	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1536	1866	1866.0	80.9	80.9	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
1537	1866	1866.0	103.6	103.6	A network theory of mental disorders.	Denny Borsboom	World Psychiatry	2017	28127906	Yes
1538	1865	1865.0	43.0	43.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1539	1865	1865.0	65.9	65.9	Transcriptional architecture of the mammalian circadian clock.	Joseph S Takahashi	Nat Rev Genet	2017	27990019	No
1540	1864	1864.0	48.5	48.5	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1541	1864	1864.0	35.9	35.9	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1542	1864	1864.0	18.0	18.0	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A ROBINSON	IEEE Trans Biomed Eng	1963	14121113	Yes
1543	1863	1863.0	44.7	44.7	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1544	14895	1861.9	415.6	52.0	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1545	3722	1861.0	74.7	37.4	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1546	3721	1860.5	83.6	41.8	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1547	1859	1859.0	57.6	57.6	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1548	3718	1859.0	84.4	42.2	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1549	1859	1859.0	45.9	45.9	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1550	3716	1858.0	134.3	67.2	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1551	1858	1858.0	52.0	52.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1552	3715	1857.5	143.4	71.7	Assays of glutathione peroxidase.	L Flohe, W A Gunzler	Methods Enzymol	1984	6727659	Yes
1553	3715	1857.5	96.4	48.2	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1554	1857	1857.0	50.5	50.5	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1555	3711	1855.5	95.1	47.5	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1556	3710	1855.0	77.8	38.9	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1557	1854	1854.0	67.6	67.6	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1558	1854	1854.0	50.9	50.9	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
1559	1854	1854.0	55.4	55.4	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1560	5561	1853.7	103.3	34.4	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1561	1851	1851.0	36.5	36.5	Protein homology detection by HMM-HMM comparison.	Johannes Soding	Bioinformatics	2005	15531603	Yes
1562	7402	1850.5	345.0	86.2	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1563	1850	1850.0	62.8	62.8	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
1564	1850	1850.0	43.2	43.2	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1565	1849	1849.0	42.0	42.0	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1566	3698	1849.0	107.0	53.5	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
1567	9243	1848.6	235.5	47.1	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1568	3697	1848.5	118.2	59.1	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1569	1848	1848.0	41.2	41.2	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1570	1848	1848.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D SIMPSON	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1571	7391	1847.8	210.7	52.7	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1572	3694	1847.0	114.2	57.1	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1573	3692	1846.0	128.9	64.5	Cisplatin in cancer therapy: molecular mechanisms of action.	Shaloam Dasari, Paul Bernard Tchounwou	Eur J Pharmacol	2014	25058905	No
1574	3691	1845.5	209.3	104.7	An Overview of Heart Rate Variability Metrics and Norms.	Fred Shaffer, J P Ginsberg	Front Public Health	2017	29034226	No
1575	3688	1844.0	52.9	26.4	Immunoassay of insulin with insulin-antibody precipitate.	C N HALES, P J RANDLE	Biochem J	1963	13952078	Yes
1576	1844	1844.0	34.3	34.3	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1577	1844	1844.0	76.4	76.4	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
1578	3687	1843.5	105.3	52.6	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
1579	5530	1843.3	121.1	40.4	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1580	1843	1843.0	65.4	65.4	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
1581	1842	1842.0	49.9	49.9	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1582	1842	1842.0	41.5	41.5	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1583	1840	1840.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C SKOU	Biochim Biophys Acta	1957	13412736	Yes
1584	9195	1839.0	97.0	19.4	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE	JAMA	1963	14044222	Yes
1585	3677	1838.5	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T CAMPBELL, D W FISKE	Psychol Bull	1959	13634291	Yes
1586	1838	1838.0	67.4	67.4	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1587	1838	1838.0	199.9	199.9	Epidemiology of chronic kidney disease: an update 2022.	Csaba P Kovesdy	Kidney Int Suppl (2011)	2022	35529086	No
1588	1837	1837.0	46.9	46.9	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1589	5510	1836.7	141.6	47.2	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1590	3673	1836.5	93.0	46.5	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1591	1836	1836.0	54.6	54.6	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1592	1836	1836.0	40.8	40.8	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1593	9172	1834.4	219.2	43.8	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1594	1833	1833.0	59.5	59.5	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1595	7331	1832.8	139.2	34.8	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1596	1832	1832.0	59.7	59.7	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1597	3662	1831.0	106.8	53.4	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1598	7315	1828.8	230.2	57.5	cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination.	Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker	Nat Methods	2017	28165473	Yes
1599	1828	1828.0	48.5	48.5	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1600	1828	1828.0	42.8	42.8	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1601	1828	1828.0	37.9	37.9	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1602	1828	1828.0	0.0	0.0	A new readability yardstick.	R FLESCH	J Appl Psychol	1948	18867058	Yes
1603	9138	1827.6	330.7	66.1	Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II.	J B Saunders, O G Aasland, T F Babor, J R de la Fuente, M Grant	Addiction	1993	8329970	Yes
1604	1826	1826.0	76.4	76.4	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
1605	1826	1826.0	38.2	38.2	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1606	5477	1825.7	121.9	40.6	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1607	3651	1825.5	90.5	45.2	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1608	3650	1825.0	135.3	67.7	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1609	3648	1824.0	74.6	37.3	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1610	7292	1823.0	281.8	70.5	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1611	3646	1823.0	80.8	40.4	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1612	3646	1823.0	101.9	51.0	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
1613	1822	1822.0	86.6	86.6	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S COHEN	J Biol Chem	1962	13880319	Yes
1614	1822	1822.0	39.3	39.3	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
1615	1820	1820.0	36.4	36.4	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1616	7279	1819.8	251.6	62.9	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
1617	1818	1818.0	62.9	62.9	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1618	19997	1817.9	495.2	45.0	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
1619	1817	1817.0	44.0	44.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1620	1817	1817.0	37.3	37.3	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1621	9085	1817.0	365.5	73.1	BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.	Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov	Bioinformatics	2015	26059717	Yes
1622	1816	1816.0	64.4	64.4	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	Yes
1623	1814	1814.0	46.5	46.5	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1624	1814	1814.0	36.0	36.0	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1625	1813	1813.0	19.1	19.1	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1626	3626	1813.0	136.8	68.4	MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.	Rajesha Rupaimoole, Frank J Slack	Nat Rev Drug Discov	2017	28209991	No
1627	3626	1813.0	362.8	181.4	Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments.	Luke A McGuinness, Julian P T Higgins	Res Synth Methods	2021	32336025	Yes
1628	5437	1812.3	174.2	58.1	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1629	18122	1812.2	565.6	56.6	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1630	1811	1811.0	59.0	59.0	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1631	3621	1810.5	118.1	59.0	Role of the microbiota in immunity and inflammation.	Yasmine Belkaid, Timothy W Hand	Cell	2014	24679531	No
1632	3621	1810.5	141.4	70.7	Interpreting findings from Mendelian randomization using the MR-Egger method.	Stephen Burgess, Simon G Thompson	Eur J Epidemiol	2017	28527048	Yes
1633	1810	1810.0	44.4	44.4	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1634	1808	1808.0	58.7	58.7	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1635	1807	1807.0	64.3	64.3	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1636	7227	1806.8	316.2	79.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1637	1805	1805.0	42.8	42.8	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1638	3604	1802.0	86.3	43.1	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1639	1802	1802.0	64.8	64.8	Structure, Function, and Evolution of Coronavirus Spike Proteins.	Fang Li	Annu Rev Virol	2016	27578435	No
1640	1800	1800.0	97.3	97.3	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1641	3600	1800.0	74.4	37.2	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1642	1800	1800.0	78.4	78.4	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1643	3599	1799.5	69.6	34.8	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1644	3598	1799.0	89.1	44.5	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1645	1799	1799.0	47.4	47.4	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
1646	3597	1798.5	91.2	45.6	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1647	3597	1798.5	110.7	55.4	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
1648	1798	1798.0	53.3	53.3	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1649	1798	1798.0	0.0	0.0	The measurement of volume changes in human limbs.	R J WHITNEY	J Physiol	1953	13085295	Yes
1650	1798	1798.0	68.0	68.0	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
1651	1798	1798.0	92.0	92.0	Epidemiology of Prostate Cancer.	Prashanth Rawla	World J Oncol	2019	31068988	No
1652	1797	1797.0	57.6	57.6	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1653	1797	1797.0	38.6	38.6	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1654	1796	1796.0	47.0	47.0	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1655	1794	1794.0	37.7	37.7	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1656	3587	1793.5	161.6	80.8	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1657	3586	1793.0	100.7	50.4	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
1658	1791	1791.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S HESTRIN	J Biol Chem	1949	18133390	Yes
1659	1790	1790.0	40.9	40.9	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1660	1790	1790.0	54.4	54.4	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1661	1790	1790.0	21.5	21.5	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1662	1790	1790.0	55.2	55.2	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1663	3579	1789.5	152.8	76.4	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1664	1789	1789.0	80.0	80.0	ROS Are Good.	Ron Mittler	Trends Plant Sci	2017	27666517	No
1665	12517	1788.1	393.8	56.3	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke,	J Clin Epidemiol	2008	18313558	Yes
1666	1787	1787.0	58.9	58.9	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1667	1787	1787.0	37.5	37.5	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1668	1783	1783.0	59.4	59.4	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1669	1783	1783.0	47.1	47.1	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1670	1782	1782.0	65.6	65.6	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1671	5346	1782.0	123.6	41.2	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Orntoft	Cancer Res	2004	15289330	Yes
1672	1782	1782.0	42.3	42.3	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
1673	3563	1781.5	89.8	44.9	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
1674	3562	1781.0	88.4	44.2	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1675	3561	1780.5	146.4	73.2	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1676	1780	1780.0	64.5	64.5	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1677	1780	1780.0	41.3	41.3	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1678	3558	1779.0	81.0	40.5	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1679	1779	1779.0	53.4	53.4	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1680	3556	1778.0	88.1	44.0	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1681	3554	1777.0	86.1	43.0	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1682	3554	1777.0	80.8	40.4	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1683	5330	1776.7	115.0	38.3	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1684	21314	1776.2	632.2	52.7	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh,	Ann Intern Med	2009	19414839	Yes
1685	1776	1776.0	49.3	49.3	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1686	1776	1776.0	36.0	36.0	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1687	1776	1776.0	50.5	50.5	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1688	1776	1776.0	46.4	46.4	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
1689	1775	1775.0	33.8	33.8	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1690	1775	1775.0	60.0	60.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1691	3550	1775.0	163.5	81.8	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
1692	1774	1774.0	39.1	39.1	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1693	1774	1774.0	59.4	59.4	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
1694	1773	1773.0	33.7	33.7	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1695	1773	1773.0	38.4	38.4	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
1696	3545	1772.5	80.3	40.1	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
1697	1772	1772.0	40.5	40.5	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
1698	10623	1770.5	213.9	35.6	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1699	1770	1770.0	46.5	46.5	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1700	1770	1770.0	38.0	38.0	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1701	1770	1770.0	74.5	74.5	When to use the Bonferroni correction.	Richard A Armstrong	Ophthalmic Physiol Opt	2014	24697967	No
1702	5309	1769.7	163.9	54.6	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1703	1769	1769.0	33.3	33.3	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1704	1769	1769.0	70.9	70.9	Biological roles of glycans.	Ajit Varki	Glycobiology	2017	27558841	No
1705	1768	1768.0	58.4	58.4	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1706	15897	1766.3	481.5	53.5	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
1707	3532	1766.0	43.7	21.9	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1708	5298	1766.0	122.8	40.9	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
1709	5297	1765.7	118.0	39.3	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1710	3531	1765.5	72.8	36.4	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1711	3529	1764.5	111.8	55.9	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
1712	7057	1764.2	212.5	53.1	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1713	3528	1764.0	150.0	75.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1714	1764	1764.0	38.7	38.7	ATPase activity of myosin correlated with speed of muscle shortening.	M Barany	J Gen Physiol	1967	4227924	Yes
1715	1764	1764.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1716	3527	1763.5	229.9	115.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1717	1763	1763.0	40.2	40.2	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1718	1763	1763.0	47.1	47.1	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1719	1763	1763.0	36.5	36.5	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
1720	1761	1761.0	60.2	60.2	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1721	1761	1761.0	40.2	40.2	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1722	3521	1760.5	130.0	65.0	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
1723	3521	1760.5	93.1	46.5	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1724	1759	1759.0	48.5	48.5	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1725	1758	1758.0	54.1	54.1	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1726	1758	1758.0	0.0	0.0	A personality scale of manifest anxiety.	J A TAYLOR	J Abnorm Psychol	1953	13052352	Yes
1727	1756	1756.0	38.3	38.3	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Sudhof	Nature	1995	7791897	No
1728	1756	1756.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J RANKIN	Scott Med J	1957	13432835	Yes
1729	1756	1756.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P MORAN	Biometrika	1950	15420245	Yes
1730	3512	1756.0	97.5	48.8	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
1731	3510	1755.0	84.7	42.4	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1732	8774	1754.8	305.0	61.0	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	J Clin Epidemiol	2009	19631508	No
1733	3509	1754.5	93.2	46.6	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1734	1753	1753.0	40.8	40.8	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1735	1753	1753.0	45.8	45.8	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1736	3506	1753.0	128.6	64.3	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
1737	3504	1752.0	84.2	42.1	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
1738	3503	1751.5	92.3	46.1	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
1739	1751	1751.0	69.0	69.0	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1740	1751	1751.0	59.5	59.5	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1741	1751	1751.0	38.3	38.3	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1742	7003	1750.8	136.2	34.0	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1743	8754	1750.8	308.7	61.7	Fsl.	Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith	Neuroimage	2012	21979382	No
1744	1750	1750.0	42.0	42.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1745	1750	1750.0	60.4	60.4	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1746	8747	1749.4	297.0	59.4	Integrating single-cell transcriptomic data across different conditions, technologies, and species.	Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija	Nat Biotechnol	2018	29608179	Yes
1747	3498	1749.0	222.5	111.2	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1748	1749	1749.0	71.6	71.6	The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.	Costantino Iadecola	Neuron	2017	28957666	No
1749	1749	1749.0	146.8	146.8	COVID-19 and mental health: A review of the existing literature.	Ravi Philip Rajkumar	Asian J Psychiatr	2020	32302935	Yes
1750	3497	1748.5	133.3	66.7	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1751	1748	1748.0	74.2	74.2	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1752	1748	1748.0	38.8	38.8	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1753	1748	1748.0	38.6	38.6	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1754	8739	1747.8	370.6	74.1	CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes.	Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson	Genome Res	2015	25977477	Yes
1755	1747	1747.0	74.9	74.9	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
1756	3494	1747.0	75.8	37.9	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1757	3493	1746.5	71.3	35.6	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1758	3493	1746.5	97.1	48.5	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1759	1744	1744.0	55.6	55.6	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
1760	1742	1742.0	62.2	62.2	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1761	3484	1742.0	72.6	36.3	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
1762	10449	1741.5	286.6	47.8	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1763	3483	1741.5	95.3	47.6	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1764	3482	1741.0	86.4	43.2	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1765	1741	1741.0	51.0	51.0	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
1766	3482	1741.0	86.2	43.1	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
1767	5222	1740.7	111.4	37.1	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1768	1739	1739.0	39.1	39.1	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1769	5214	1738.0	271.8	90.6	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1770	1738	1738.0	17.5	17.5	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1771	1738	1738.0	47.4	47.4	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
1772	3474	1737.0	72.1	36.0	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flugge	Anal Biochem	1984	6731838	Yes
1773	1737	1737.0	69.2	69.2	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1774	1736	1736.0	31.9	31.9	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1775	1736	1736.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H SELYE	J Clin Endocrinol Metab	1946	21025115	Yes
1776	1735	1735.0	55.8	55.8	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1777	3470	1735.0	68.7	34.4	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1778	3469	1734.5	90.0	45.0	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1779	17327	1732.7	549.1	54.9	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1780	3465	1732.5	82.1	41.0	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1781	3465	1732.5	96.3	48.1	Molecular and cellular insights into T cell exhaustion.	E John Wherry, Makoto Kurachi	Nat Rev Immunol	2015	26205583	No
1782	1732	1732.0	52.4	52.4	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1783	1732	1732.0	65.1	65.1	Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.	Karimollah Hajian-Tilaki	Caspian J Intern Med	2013	24009950	No
1784	1732	1732.0	69.9	69.9	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
1785	5195	1731.7	202.1	67.4	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1786	6925	1731.2	215.0	53.8	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Soren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1787	1731	1731.0	62.3	62.3	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1788	1730	1730.0	31.4	31.4	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1789	1730	1730.0	44.6	44.6	BEDTools: The Swiss-Army Tool for Genome Feature Analysis.	Aaron R Quinlan	Curr Protoc Bioinformatics	2014	25199790	Yes
1790	3459	1729.5	66.7	33.4	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1791	1729	1729.0	31.6	31.6	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1792	1729	1729.0	71.0	71.0	The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health.	Lisa Bowleg	Am J Public Health	2012	22594719	Yes
1793	1728	1728.0	43.9	43.9	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1794	1728	1728.0	51.9	51.9	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
1795	5182	1727.3	111.7	37.2	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1796	1727	1727.0	48.4	48.4	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1797	3454	1727.0	129.4	64.7	The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities.	Samuel Genheden, Ulf Ryde	Expert Opin Drug Discov	2015	25835573	No
1798	1726	1726.0	66.2	66.2	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1799	1726	1726.0	44.4	44.4	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1800	1726	1726.0	36.0	36.0	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1801	1726	1726.0	30.7	30.7	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1802	1725	1725.0	55.9	55.9	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1803	3448	1724.0	198.3	99.2	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1804	1722	1722.0	72.9	72.9	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1805	3444	1722.0	70.2	35.1	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1806	3443	1721.5	73.5	36.8	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1807	5164	1721.3	230.3	76.8	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1808	1721	1721.0	55.8	55.8	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1809	3442	1721.0	84.6	42.3	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
1810	1720	1720.0	62.0	62.0	Inflammation, metaflammation and immunometabolic disorders.	Gokhan S Hotamisligil	Nature	2017	28179656	No
1811	3437	1718.5	78.0	39.0	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1812	1717	1717.0	51.9	51.9	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1813	1717	1717.0	44.3	44.3	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1814	1717	1717.0	45.9	45.9	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1815	1717	1717.0	33.2	33.2	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1816	1715	1715.0	38.1	38.1	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1817	1714	1714.0	41.8	41.8	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1818	6856	1714.0	288.6	72.2	NF-κB signaling in inflammation.	Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun	Signal Transduct Target Ther	2017	29158945	Yes
1819	3427	1713.5	104.0	52.0	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1820	3427	1713.5	122.2	61.1	The Warburg Effect: How Does it Benefit Cancer Cells?	Maria V Liberti, Jason W Locasale	Trends Biochem Sci	2016	26778478	No
1821	1712	1712.0	35.5	35.5	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1822	5136	1712.0	130.6	43.5	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1823	1711	1711.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A LASSEN	Physiol Rev	1959	13645234	Yes
1824	6842	1710.5	143.8	36.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1825	3419	1709.5	113.3	56.6	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
1826	3418	1709.0	129.2	64.6	A typology of reviews: an analysis of 14 review types and associated methodologies.	Maria J Grant, Andrew Booth	Health Info Libr J	2009	19490148	No
1827	1709	1709.0	62.7	62.7	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
1828	3417	1708.5	82.5	41.2	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1829	3414	1707.0	49.6	24.8	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J KARNOVSKY, L ROOTS	J Histochem Cytochem	1964	14187330	Yes
1830	1707	1707.0	35.5	35.5	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
1831	1707	1707.0	45.6	45.6	Surface plasmon resonance sensors for detection of chemical and biological species.	Jiri Homola	Chem Rev	2008	18229953	No
1832	3413	1706.5	71.2	35.6	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
1833	3413	1706.5	118.6	59.3	Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.	Roel Nusse, Hans Clevers	Cell	2017	28575679	No
1834	1705	1705.0	85.0	85.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerstrom	Addict Behav	1978	735910	Yes
1835	1705	1705.0	37.9	37.9	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1836	3410	1705.0	70.3	35.1	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1837	1705	1705.0	37.5	37.5	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1838	3409	1704.5	192.5	96.2	Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.	Helmut Sies, Dean P Jones	Nat Rev Mol Cell Biol	2020	32231263	No
1839	1704	1704.0	42.8	42.8	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1840	1702	1702.0	33.0	33.0	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1841	1702	1702.0	41.4	41.4	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1842	1702	1702.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1843	1702	1702.0	54.2	54.2	PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints.	Chun Wei Yap	J Comput Chem	2011	21425294	Yes
1844	1702	1702.0	64.0	64.0	Rhythms for Cognition: Communication through Coherence.	Pascal Fries	Neuron	2015	26447583	No
1845	3401	1700.5	79.8	39.9	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1846	1700	1700.0	55.3	55.3	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1847	3400	1700.0	66.4	33.2	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1848	3400	1700.0	95.9	48.0	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
1849	1700	1700.0	47.2	47.2	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
1850	5097	1699.0	97.5	32.5	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1851	3394	1697.0	71.3	35.6	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
1852	3393	1696.5	79.3	39.6	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1853	1696	1696.0	31.2	31.2	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1854	3390	1695.0	110.6	55.3	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1855	1695	1695.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G GRAY	J Anat	1959	13829103	Yes
1856	3389	1694.5	91.9	46.0	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1857	10165	1694.2	231.6	38.6	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1858	1694	1694.0	40.1	40.1	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1859	1694	1694.0	40.1	40.1	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1860	1694	1694.0	38.4	38.4	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1861	1694	1694.0	38.4	38.4	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1862	3386	1693.0	93.2	46.6	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1863	3386	1693.0	99.3	49.6	Unified approach for molecular dynamics and density-functional theory.	R Car, M Parrinello	Phys Rev Lett	1985	10032153	Yes
1864	3385	1692.5	73.2	36.6	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1865	1692	1692.0	32.0	32.0	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1866	1692	1692.0	29.0	29.0	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H MOLLENHAUER	Stain Technol	1964	14127791	Yes
1867	1692	1692.0	45.1	45.1	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1868	1691	1691.0	45.0	45.0	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1869	1691	1691.0	48.7	48.7	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
1870	1691	1691.0	49.1	49.1	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1871	1691	1691.0	43.1	43.1	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1872	1691	1691.0	41.7	41.7	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
1873	3382	1691.0	74.8	37.4	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1874	5072	1690.7	110.0	36.7	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M G Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1875	1689	1689.0	22.6	22.6	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1876	10130	1688.3	323.8	54.0	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
1877	1688	1688.0	83.1	83.1	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1878	1688	1688.0	53.1	53.1	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1879	1687	1687.0	73.6	73.6	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1880	5060	1686.7	136.2	45.4	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
1881	1686	1686.0	58.8	58.8	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1882	1686	1686.0	32.6	32.6	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1883	1686	1686.0	33.5	33.5	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1884	1686	1686.0	45.3	45.3	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
1885	3370	1685.0	107.3	53.6	Mendelian randomization: genetic anchors for causal inference in epidemiological studies.	George Davey Smith, Gibran Hemani	Hum Mol Genet	2014	25064373	No
1886	1685	1685.0	84.6	84.6	Cell death: a review of the major forms of apoptosis, necrosis and autophagy.	Mark S D'Arcy	Cell Biol Int	2019	30958602	No
1887	6738	1684.5	258.3	64.6	Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.	Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess	Genet Epidemiol	2016	27061298	Yes
1888	1683	1683.0	33.9	33.9	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
1889	10089	1681.5	227.9	38.0	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O Lotvall	Nat Cell Biol	2007	17486113	Yes
1890	1681	1681.0	43.3	43.3	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1891	1681	1681.0	38.2	38.2	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1892	1680	1680.0	49.9	49.9	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
1893	1679	1679.0	47.7	47.7	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
1894	1679	1679.0	42.9	42.9	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1895	1679	1679.0	14.1	14.1	Chromatographic Separation Of Human Brain Gangliosides.	L SVENNERHOLM	J Neurochem	1963	14066623	Yes
1896	1679	1679.0	36.7	36.7	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1897	10072	1678.7	348.6	58.1	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1898	1677	1677.0	49.3	49.3	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1899	1677	1677.0	76.6	76.6	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
1900	1675	1675.0	58.8	58.8	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1901	1674	1674.0	58.2	58.2	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1902	1674	1674.0	32.1	32.1	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1903	3347	1673.5	94.8	47.4	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
1904	1673	1673.0	40.4	40.4	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1905	1672	1672.0	65.0	65.0	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
1906	3344	1672.0	93.1	46.5	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
1907	5013	1671.0	180.5	60.2	Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.	C J Caspersen, K E Powell, G M Christenson	Public Health Rep	1985	3920711	Yes
1908	1671	1671.0	39.4	39.4	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
1909	1670	1670.0	37.5	37.5	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1910	1670	1670.0	52.0	52.0	Phenylpropanoid biosynthesis.	Thomas Vogt	Mol Plant	2010	20035037	No
1911	6678	1669.5	214.3	53.6	Near-optimal probabilistic RNA-seq quantification.	Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior Pachter	Nat Biotechnol	2016	27043002	Yes
1912	5008	1669.3	137.8	45.9	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1913	3338	1669.0	85.9	43.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1914	1669	1669.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F BOAS	J Biol Chem	1953	13117829	Yes
1915	3338	1669.0	180.8	90.4	Osteoarthritis.	David J Hunter, Sita Bierma-Zeinstra	Lancet	2019	31034380	No
1916	1668	1668.0	52.2	52.2	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1917	1667	1667.0	39.3	39.3	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1918	1666	1666.0	41.7	41.7	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1919	1666	1666.0	31.7	31.7	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1920	1666	1666.0	39.9	39.9	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvarinen	IEEE Trans Neural Netw	1999	18252563	Yes
1921	3331	1665.5	54.2	27.1	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T OMURA, R SATO	J Biol Chem	1964	14209972	Yes
1922	1664	1664.0	63.4	63.4	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1923	4992	1664.0	125.5	41.8	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
1924	1664	1664.0	37.5	37.5	Upconversion and anti-Stokes processes with f and d ions in solids.	Francois Auzel	Chem Rev	2004	14719973	Yes
1925	3328	1664.0	69.2	34.6	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1926	1664	1664.0	34.8	34.8	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1927	3327	1663.5	80.8	40.4	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
1928	4990	1663.3	104.9	35.0	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
1929	1663	1663.0	50.3	50.3	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
1930	3326	1663.0	105.6	52.8	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
1931	3323	1661.5	60.5	30.2	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1932	3321	1660.5	63.7	31.9	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1933	6642	1660.5	154.7	38.7	CHARMM-GUI: a web-based graphical user interface for CHARMM.	Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im	J Comput Chem	2008	18351591	No
1934	8301	1660.2	285.0	57.0	Salmon provides fast and bias-aware quantification of transcript expression.	Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford	Nat Methods	2017	28263959	Yes
1935	1660	1660.0	49.0	49.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1936	3320	1660.0	93.7	46.9	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
1937	1660	1660.0	61.2	61.2	1,500 scientists lift the lid on reproducibility.	Monya Baker	Nature	2016	27225100	No
1938	4978	1659.3	268.3	89.4	MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.	Kazutaka Katoh, John Rozewicki, Kazunori D Yamada	Brief Bioinform	2019	28968734	Yes
1939	1659	1659.0	46.9	46.9	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1940	1659	1659.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S KETY	Pharmacol Rev	1951	14833874	Yes
1941	3316	1658.0	71.3	35.6	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1942	3315	1657.5	82.8	41.4	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1943	6630	1657.5	151.5	37.9	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1944	1657	1657.0	56.7	56.7	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1945	1657	1657.0	31.2	31.2	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1946	4970	1656.7	119.0	39.7	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1947	4969	1656.3	163.8	54.6	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
1948	1656	1656.0	36.2	36.2	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	Yes
1949	1656	1656.0	36.9	36.9	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1950	1656	1656.0	44.0	44.0	Subcutaneous and visceral adipose tissue: structural and functional differences.	M Mohsen Ibrahim	Obes Rev	2010	19656312	No
1951	3312	1656.0	97.1	48.5	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1952	1656	1656.0	68.8	68.8	Sleep health: can we define it? Does it matter?	Daniel J Buysse	Sleep	2014	24470692	Yes
1953	6621	1655.2	154.4	38.6	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1954	3305	1652.5	240.5	120.2	Gut microbiota in human metabolic health and disease.	Yong Fan, Oluf Pedersen	Nat Rev Microbiol	2021	32887946	No
1955	1652	1652.0	50.2	50.2	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1956	1651	1651.0	53.2	53.2	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1957	3299	1649.5	59.2	29.6	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1958	4948	1649.3	125.5	41.8	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
1959	1649	1649.0	39.5	39.5	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1960	1648	1648.0	33.3	33.3	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1961	3295	1647.5	93.0	46.5	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
1962	3294	1647.0	65.8	32.9	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1963	1646	1646.0	56.7	56.7	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1964	1646	1646.0	45.0	45.0	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1965	1646	1646.0	22.5	22.5	Structural considerations in the interaction of DNA and acridines.	L S LERMAN	J Mol Biol	1961	13761054	Yes
1966	1646	1646.0	38.0	38.0	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1967	3292	1646.0	94.9	47.5	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
1968	3292	1646.0	66.9	33.5	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massague	Cell	2006	17110329	No
1969	1645	1645.0	47.8	47.8	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1970	3289	1644.5	97.0	48.5	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1971	3289	1644.5	77.7	38.9	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1972	3289	1644.5	74.0	37.0	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1973	3288	1644.0	75.3	37.6	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1974	1644	1644.0	43.9	43.9	Bioactive microbial metabolites.	Janos Berdy	J Antibiot (Tokyo)	2005	15813176	No
1975	1643	1643.0	48.2	48.2	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1976	1643	1643.0	38.9	38.9	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1977	1643	1643.0	41.4	41.4	Aspergillus fumigatus and aspergillosis.	J P Latge	Clin Microbiol Rev	1999	10194462	No
1978	1643	1643.0	55.4	55.4	Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis.	George S Bloom	JAMA Neurol	2014	24493463	No
1979	11498	1642.6	269.9	38.6	Integrative genomics viewer.	James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov	Nat Biotechnol	2011	21221095	Yes
1980	6570	1642.5	214.6	53.6	The chemistry and applications of metal-organic frameworks.	Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi	Science	2013	23990564	Yes
1981	1642	1642.0	30.3	30.3	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1982	6568	1642.0	286.7	71.7	Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.	Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do	Nat Genet	2018	29686387	Yes
1983	13134	1641.8	308.8	38.6	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan,	N Engl J Med	2002	11832527	Yes
1984	3283	1641.5	71.4	35.7	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1985	1641	1641.0	34.8	34.8	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1986	1641	1641.0	30.3	30.3	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1987	1641	1641.0	43.1	43.1	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1988	1640	1640.0	28.8	28.8	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1989	1639	1639.0	45.0	45.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1990	1639	1639.0	27.5	27.5	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1991	1639	1639.0	30.1	30.1	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1992	1638	1638.0	64.2	64.2	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
1993	1638	1638.0	34.5	34.5	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1994	1638	1638.0	56.6	56.6	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
1995	3276	1638.0	78.4	39.2	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
1996	1637	1637.0	51.0	51.0	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1997	1637	1637.0	71.9	71.9	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1998	3272	1636.0	65.7	32.9	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1999	1636	1636.0	29.7	29.7	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
2000	1635	1635.0	28.6	28.6	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
2001	3270	1635.0	103.8	51.9	Factors affecting wound healing.	S Guo, L A Dipietro	J Dent Res	2010	20139336	No
2002	1635	1635.0	45.7	45.7	Nanobodies: natural single-domain antibodies.	Serge Muyldermans	Annu Rev Biochem	2013	23495938	No
2003	4904	1634.7	93.9	31.3	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jurg Tschopp	Mol Cell	2002	12191486	Yes
2004	1634	1634.0	102.8	102.8	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D MATTINGLY	J Clin Pathol	1962	14471419	Yes
2005	3267	1633.5	76.7	38.4	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
2006	1633	1633.0	51.3	51.3	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2007	3265	1632.5	192.9	96.5	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
2008	3265	1632.5	65.9	33.0	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
2009	1632	1632.0	42.7	42.7	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
2010	1632	1632.0	29.4	29.4	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
2011	1632	1632.0	35.7	35.7	Thiazolidinediones.	Hannele Yki-Jarvinen	N Engl J Med	2004	15356308	No
2012	8157	1631.4	292.5	58.5	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	Int J Surg	2010	20171303	No
2013	3262	1631.0	181.1	90.5	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J MARMUR, P DOTY	J Mol Biol	1962	14470099	Yes
2014	1631	1631.0	31.3	31.3	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
2015	1630	1630.0	52.4	52.4	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
2016	4890	1630.0	136.4	45.5	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
2017	1630	1630.0	34.7	34.7	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
2018	4888	1629.3	54.1	18.0	Improved method for the determination of blood glutathione.	E BEUTLER, O DURON, B M KELLY	J Lab Clin Med	1963	13967893	Yes
2019	1629	1629.0	51.1	51.1	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
2020	1629	1629.0	42.4	42.4	Sarcopenia: origins and clinical relevance.	I H Rosenberg	J Nutr	1997	9164280	No
2021	1628	1628.0	45.7	45.7	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
2022	1628	1628.0	36.8	36.8	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
2023	1627	1627.0	112.9	112.9	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
2024	1627	1627.0	57.9	57.9	Cell damage in the brain: a speculative synthesis.	B K Siesjo	J Cereb Blood Flow Metab	1981	6276420	No
2025	3253	1626.5	63.7	31.9	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2026	3253	1626.5	150.7	75.3	Breast Cancer Treatment: A Review.	Adrienne G Waks, Eric P Winer	JAMA	2019	30667505	No
2027	1626	1626.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W KUFFLER	J Neurophysiol	1953	13035466	Yes
2028	3252	1626.0	81.4	40.7	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
2029	3250	1625.0	66.9	33.5	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
2030	1625	1625.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L WELCH	Biometrika	1947	20287819	Yes
2031	1624	1624.0	46.1	46.1	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinas	Science	1988	3059497	No
2032	1624	1624.0	71.3	71.3	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
2033	1624	1624.0	50.9	50.9	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2034	3248	1624.0	78.0	39.0	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
2035	1623	1623.0	47.3	47.3	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
2036	1623	1623.0	70.3	70.3	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
2037	3246	1623.0	80.2	40.1	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2038	1623	1623.0	48.3	48.3	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2039	3244	1622.0	62.6	31.3	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
2040	9727	1621.2	286.1	47.7	The Molecular Signatures Database (MSigDB) hallmark gene set collection.	Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo	Cell Syst	2015	26771021	Yes
2041	1621	1621.0	40.2	40.2	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2042	3242	1621.0	60.6	30.3	Mutations affecting segment number and polarity in Drosophila.	C Nusslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
2043	3242	1621.0	95.7	47.9	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow,	Pediatrics	2007	18055651	Yes
2044	1620	1620.0	29.8	29.8	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
2045	1620	1620.0	33.1	33.1	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
2046	3240	1620.0	78.1	39.0	Abdominal obesity and metabolic syndrome.	Jean-Pierre Despres, Isabelle Lemieux	Nature	2006	17167477	No
2047	1619	1619.0	34.2	34.2	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
2048	1619	1619.0	26.3	26.3	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
2049	1619	1619.0	31.6	31.6	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
2050	3237	1618.5	105.3	52.6	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2051	1618	1618.0	51.6	51.6	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
2052	1617	1617.0	29.5	29.5	How cells read TGF-beta signals.	J Massague	Nat Rev Mol Cell Biol	2000	11252892	No
2053	3233	1616.5	77.1	38.5	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2054	1616	1616.0	40.4	40.4	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
2055	4848	1616.0	115.3	38.4	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
2056	1616	1616.0	52.1	52.1	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Frohlich	Int J Nanomedicine	2012	23144561	No
2057	1615	1615.0	33.6	33.6	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
2058	3229	1614.5	78.9	39.5	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
2059	1614	1614.0	19.4	19.4	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W CLELAND	Biochemistry	1964	14192894	Yes
2060	3228	1614.0	76.9	38.5	Dali server: conservation mapping in 3D.	Liisa Holm, Paivi Rosenstrom	Nucleic Acids Res	2010	20457744	Yes
2061	1613	1613.0	32.9	32.9	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
2062	3226	1613.0	100.4	50.2	The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample.	Julie D Henry, John R Crawford	Br J Clin Psychol	2005	16004657	Yes
2063	4837	1612.3	153.5	51.2	Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.	Marina Colombo, Graca Raposo, Clotilde Thery	Annu Rev Cell Dev Biol	2014	25288114	No
2064	3224	1612.0	82.4	41.2	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2065	1612	1612.0	46.6	46.6	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2066	4835	1611.7	115.9	38.6	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2067	1611	1611.0	49.4	49.4	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
2068	1611	1611.0	49.9	49.9	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
2069	1611	1611.0	56.6	56.6	Microtiter dish biofilm formation assay.	George A O'Toole	J Vis Exp	2011	21307833	Yes
2070	3221	1610.5	88.4	44.2	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
2071	1610	1610.0	28.9	28.9	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
2072	1609	1609.0	34.2	34.2	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2073	3214	1607.0	57.3	28.6	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
2074	4821	1607.0	117.3	39.1	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman,	Hepatology	2005	16250051	No
2075	1607	1607.0	33.1	33.1	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2076	3213	1606.5	91.5	45.8	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
2077	3213	1606.5	63.3	31.6	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
2078	3212	1606.0	110.6	55.3	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
2079	3212	1606.0	112.9	56.5	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
2080	1606	1606.0	36.4	36.4	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
2081	1606	1606.0	50.0	50.0	ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps.	Tristan Ian Croll	Acta Crystallogr D Struct Biol	2018	29872003	Yes
2082	16056	1605.6	374.8	37.5	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
2083	3210	1605.0	61.1	30.6	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
2084	12840	1605.0	312.5	39.1	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2085	9628	1604.7	273.6	45.6	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
2086	3209	1604.5	88.7	44.4	A fast, lock-free approach for efficient parallel counting of occurrences of k-mers.	Guillaume Marcais, Carl Kingsford	Bioinformatics	2011	21217122	Yes
2087	1603	1603.0	29.1	29.1	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
2088	1603	1603.0	75.8	75.8	Non-alcoholic fatty liver disease - A global public health perspective.	Zobair M Younossi	J Hepatol	2019	30414863	No
2089	4805	1601.7	88.3	29.4	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
2090	1601	1601.0	44.6	44.6	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
2091	1601	1601.0	34.1	34.1	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
2092	3201	1600.5	67.0	33.5	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
2093	1600	1600.0	39.5	39.5	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
2094	1600	1600.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O OUCHTERLONY	Acta Pathol Microbiol Scand	1953	13079779	Yes
2095	1599	1599.0	31.4	31.4	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
2096	1599	1599.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H EAGLE	Science	1955	13255879	Yes
2097	1599	1599.0	47.6	47.6	Evaluating the quality of medical care. 1966.	Avedis Donabedian	Milbank Q	2005	16279964	No
2098	1599	1599.0	58.4	58.4	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylha	Soc Sci Med	2009	19520474	Yes
2099	4796	1598.7	94.3	31.4	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
2100	1598	1598.0	81.4	81.4	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2101	1598	1598.0	35.4	35.4	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
2102	3195	1597.5	77.4	38.7	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
2103	7987	1597.4	153.3	30.7	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
2104	6389	1597.2	262.1	65.5	Progressive statistics for studies in sports medicine and exercise science.	William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin	Med Sci Sports Exerc	2009	19092709	No
2105	6385	1596.2	150.4	37.6	Universal sample preparation method for proteome analysis.	Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2106	1596	1596.0	48.2	48.2	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
2107	1596	1596.0	45.7	45.7	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2108	3192	1596.0	113.7	56.9	Macrophages in Tissue Repair, Regeneration, and Fibrosis.	Thomas A Wynn, Kevin M Vannella	Immunity	2016	26982353	No
2109	4787	1595.7	92.6	30.9	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2110	3190	1595.0	72.5	36.2	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
2111	1595	1595.0	33.2	33.2	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
2112	1593	1593.0	36.4	36.4	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
2113	3186	1593.0	60.4	30.2	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
2114	1593	1593.0	37.5	37.5	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2115	1592	1592.0	50.2	50.2	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2116	1592	1592.0	39.6	39.6	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2117	1591	1591.0	42.8	42.8	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
2118	3182	1591.0	63.1	31.6	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
2119	6360	1590.0	314.4	78.6	Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads.	Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt	PLoS Comput Biol	2017	28594827	Yes
2120	11127	1589.6	358.5	51.2	Metagenomic biomarker discovery and explanation.	Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower	Genome Biol	2011	21702898	Yes
2121	1589	1589.0	54.4	54.4	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2122	1589	1589.0	37.6	37.6	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
2123	1589	1589.0	60.3	60.3	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2124	1588	1588.0	53.8	53.8	Glutathione synthesis.	Shelly C Lu	Biochim Biophys Acta	2013	22995213	No
2125	3176	1588.0	89.8	44.9	Tumor-associated macrophages: from mechanisms to therapy.	Roy Noy, Jeffrey W Pollard	Immunity	2014	25035953	No
2126	3175	1587.5	96.0	48.0	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
2127	1587	1587.0	31.5	31.5	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
2128	4758	1586.0	157.4	52.5	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
2129	1586	1586.0	29.6	29.6	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
2130	3171	1585.5	118.2	59.1	Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies.	Peter C Austin, Elizabeth A Stuart	Stat Med	2015	26238958	Yes
2131	4756	1585.3	119.8	39.9	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2132	1584	1584.0	45.0	45.0	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2133	20589	1583.8	514.9	39.6	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2134	1583	1583.0	41.1	41.1	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
2135	1583	1583.0	33.4	33.4	Measuring information transfer	T Schreiber	Phys Rev Lett	2000	10991308	Yes
2136	6332	1583.0	154.3	38.6	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2137	3165	1582.5	100.6	50.3	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
2138	1582	1582.0	47.0	47.0	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
2139	3162	1581.0	65.9	33.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
2140	1581	1581.0	78.8	78.8	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
2141	1581	1581.0	40.7	40.7	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2142	6321	1580.2	181.1	45.3	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2143	1580	1580.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C HUMMEL	Can J Biochem Physiol	1959	14405350	Yes
2144	1579	1579.0	52.6	52.6	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
2145	1579	1579.0	35.1	35.1	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
2146	1578	1578.0	64.5	64.5	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
2147	1578	1578.0	44.9	44.9	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
2148	4730	1576.7	128.9	43.0	The Patient Health Questionnaire-2: validity of a two-item depression screener.	Kurt Kroenke, Robert L Spitzer, Janet B W Williams	Med Care	2003	14583691	Yes
2149	3153	1576.5	97.5	48.8	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2150	3153	1576.5	61.1	30.6	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2151	3150	1575.0	99.1	49.5	MissForest--non-parametric missing value imputation for mixed-type data.	Daniel J Stekhoven, Peter Buhlmann	Bioinformatics	2012	22039212	Yes
2152	1574	1574.0	42.5	42.5	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
2153	1574	1574.0	41.1	41.1	Levels of racism: a theoretic framework and a gardener's tale.	C P Jones	Am J Public Health	2000	10936998	Yes
2154	3147	1573.5	95.5	47.8	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2155	4717	1572.3	111.2	37.1	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2156	1572	1572.0	46.9	46.9	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2157	6287	1571.8	119.0	29.8	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
2158	1571	1571.0	58.9	58.9	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
2159	1571	1571.0	43.9	43.9	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2160	4710	1570.0	162.0	54.0	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
2161	4708	1569.3	141.3	47.1	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2162	1569	1569.0	38.7	38.7	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
2163	1569	1569.0	57.2	57.2	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2164	3137	1568.5	100.7	50.4	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
2165	1568	1568.0	49.2	49.2	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2166	1568	1568.0	51.2	51.2	Density matrix formulation for quantum renormalization groups.	S R White	Phys Rev Lett	1992	10046608	Yes
2167	3136	1568.0	89.5	44.8	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2168	4704	1568.0	111.8	37.3	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2169	1568	1568.0	29.5	29.5	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L RAMANATHAN	J Appl Physiol	1964	14173555	Yes
2170	3135	1567.5	80.0	40.0	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
2171	3134	1567.0	21.8	10.9	Junctional complexes in various epithelia.	M G FARQUHAR, G E PALADE	J Cell Biol	1963	13944428	Yes
2172	1565	1565.0	59.4	59.4	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2173	1564	1564.0	35.3	35.3	Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology.	Christopher Paul Wild	Cancer Epidemiol Biomarkers Prev	2005	16103423	No
2174	4689	1563.0	128.4	42.8	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
2175	1563	1563.0	69.0	69.0	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2176	1563	1563.0	42.5	42.5	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2177	1563	1563.0	46.3	46.3	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2178	3124	1562.0	38.5	19.2	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
2179	4684	1561.3	286.2	95.4	Correlation Coefficients: Appropriate Use and Interpretation.	Patrick Schober, Christa Boer, Lothar A Schwarte	Anesth Analg	2018	29481436	No
2180	1560	1560.0	33.1	33.1	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2181	1560	1560.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
2182	1560	1560.0	38.9	38.9	Bacteroides: the good, the bad, and the nitty-gritty.	Hannah M Wexler	Clin Microbiol Rev	2007	17934076	No
2183	7798	1559.6	387.9	77.6	Standards for reporting qualitative research: a synthesis of recommendations.	Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook	Acad Med	2014	24979285	Yes
2184	1559	1559.0	52.9	52.9	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
2185	3118	1559.0	68.1	34.0	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
2186	1559	1559.0	41.5	41.5	The pollution of the marine environment by plastic debris: a review.	Jose G B Derraik	Mar Pollut Bull	2002	12405208	No
2187	9352	1558.7	318.2	53.0	StringTie enables improved reconstruction of a transcriptome from RNA-seq reads.	Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg	Nat Biotechnol	2015	25690850	Yes
2188	1558	1558.0	36.3	36.3	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
2189	3116	1558.0	60.7	30.4	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
2190	1558	1558.0	83.7	83.7	Head and Neck Cancer.	Laura Q M Chow	N Engl J Med	2020	31893516	No
2191	1557	1557.0	28.2	28.2	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
2192	1557	1557.0	33.7	33.7	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2193	1556	1556.0	32.5	32.5	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2194	3111	1555.5	89.2	44.6	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2195	1555	1555.0	31.1	31.1	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
2196	1554	1554.0	43.7	43.7	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
2197	10865	1552.1	227.6	32.5	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
2198	1552	1552.0	49.5	49.5	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2199	4654	1551.3	102.5	34.2	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
2200	1551	1551.0	98.5	98.5	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2201	1551	1551.0	12.6	12.6	The Relation Of Recombination To Mutational Advance.	H J MULLER	Mutat Res	1964	14195748	Yes
2202	1551	1551.0	34.1	34.1	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2203	1550	1550.0	93.7	93.7	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
2204	3100	1550.0	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbruck	Genetics	1943	17247100	Yes
2205	1550	1550.0	31.7	31.7	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2206	1550	1550.0	59.9	59.9	The Laboratory Rat: Relating Its Age With Human's.	Pallav Sengupta	Int J Prev Med	2013	23930179	Yes
2207	4648	1549.3	156.2	52.1	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2208	1549	1549.0	55.1	55.1	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
2209	1549	1549.0	44.7	44.7	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
2210	1547	1547.0	43.0	43.0	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
2211	1547	1547.0	35.8	35.8	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2212	1547	1547.0	39.5	39.5	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2213	1547	1547.0	62.5	62.5	Salience processing and insular cortical function and dysfunction.	Lucina Q Uddin	Nat Rev Neurosci	2015	25406711	No
2214	1546	1546.0	18.3	18.3	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
2215	3091	1545.5	100.3	50.1	Nitric oxide synthases: regulation and function.	Ulrich Forstermann, William C Sessa	Eur Heart J	2012	21890489	No
2216	1545	1545.0	45.6	45.6	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2217	1545	1545.0	45.5	45.5	Strong localization of photons in certain disordered dielectric superlattices.	S John	Phys Rev Lett	1987	10034761	Yes
2218	3089	1544.5	71.0	35.5	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
2219	4632	1544.0	89.1	29.7	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
2220	3088	1544.0	111.3	55.6	The content validity index: are you sure you know what's being reported? Critique and recommendations.	Denise F Polit, Cheryl Tatano Beck	Res Nurs Health	2006	16977646	Yes
2221	4631	1543.7	96.9	32.3	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
2222	1543	1543.0	27.7	27.7	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
2223	1543	1543.0	33.9	33.9	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2224	4628	1542.7	143.5	47.8	AChE-stained horizontal sections of the rat brain in stereotaxic coordinates.	G Paxinos, C R Watson, P C Emson	J Neurosci Methods	1980	6110810	Yes
2225	1542	1542.0	58.0	58.0	Minority stress and mental health in gay men.	I H Meyer	J Health Soc Behav	1995	7738327	Yes
2226	3084	1542.0	66.9	33.5	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
2227	1542	1542.0	42.8	42.8	Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE.	Louis B Rice	J Infect Dis	2008	18419525	No
2228	1542	1542.0	73.9	73.9	Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV.	Douglas A Drossman	Gastroenterology	2016	27144617	Yes
2229	3082	1541.0	104.5	52.2	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2230	1541	1541.0	33.3	33.3	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
2231	4621	1540.3	93.7	31.2	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
2232	1540	1540.0	71.3	71.3	Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis.	Hae-Young Kim	Restor Dent Endod	2013	23495371	Yes
2233	1539	1539.0	30.0	30.0	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
2234	1539	1539.0	45.8	45.8	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
2235	4615	1538.3	104.7	34.9	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2236	3075	1537.5	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G SCHMIDT, S J THANNHAUSER	J Biol Chem	1945	21005717	Yes
2237	3073	1536.5	78.8	39.4	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2238	3073	1536.5	124.4	62.2	AMPK: guardian of metabolism and mitochondrial homeostasis.	Sebastien Herzig, Reuben J Shaw	Nat Rev Mol Cell Biol	2018	28974774	No
2239	9218	1536.3	327.4	54.6	Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science.	Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery	Implement Sci	2009	19664226	Yes
2240	1536	1536.0	57.3	57.3	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
2241	1536	1536.0	32.4	32.4	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2242	3070	1535.0	118.5	59.2	Using Effect Size-or Why the P Value Is Not Enough.	Gail M Sullivan, Richard Feinn	J Grad Med Educ	2012	23997866	Yes
2243	1534	1534.0	56.6	56.6	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
2244	1534	1534.0	33.6	33.6	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
2245	1534	1534.0	50.3	50.3	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
2246	4602	1534.0	136.9	45.6	Evaluating the public health impact of health promotion interventions: the RE-AIM framework.	R E Glasgow, T M Vogt, S M Boles	Am J Public Health	1999	10474547	No
2247	1534	1534.0	37.6	37.6	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
2248	1534	1534.0	37.6	37.6	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2249	1534	1534.0	38.7	38.7	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2250	1533	1533.0	45.2	45.2	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2251	1533	1533.0	43.6	43.6	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2252	6131	1532.8	212.1	53.0	MultiQC: summarize analysis results for multiple tools and samples in a single report.	Philip Ewels, Mans Magnusson, Sverker Lundin, Max Kaller	Bioinformatics	2016	27312411	Yes
2253	3065	1532.5	99.6	49.8	Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.	John F Cryan, Timothy G Dinan	Nat Rev Neurosci	2012	22968153	No
2254	1532	1532.0	40.9	40.9	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
2255	1531	1531.0	50.4	50.4	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
2256	1531	1531.0	22.4	22.4	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2257	3062	1531.0	79.6	39.8	Verification of protein structures: patterns of nonbonded atomic interactions.	C Colovos, T O Yeates	Protein Sci	1993	8401235	Yes
2258	1531	1531.0	35.1	35.1	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2259	4592	1530.7	150.5	50.2	Job burnout.	C Maslach, W B Schaufeli, M P Leiter	Annu Rev Psychol	2001	11148311	Yes
2260	3061	1530.5	90.4	45.2	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
2261	1530	1530.0	27.1	27.1	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
2262	3060	1530.0	58.7	29.4	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2263	1530	1530.0	39.6	39.6	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2264	1529	1529.0	21.2	21.2	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
2265	1529	1529.0	42.8	42.8	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2266	1528	1528.0	30.7	30.7	Antigen-Antibody Crossed Electrophoresis.	C B LAURELL	Anal Biochem	1965	14302464	Yes
2267	4583	1527.7	164.9	55.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
2268	1527	1527.0	26.7	26.7	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
2269	4579	1526.3	140.5	46.8	Mendelian randomization analysis with multiple genetic variants using summarized data.	Stephen Burgess, Adam Butterworth, Simon G Thompson	Genet Epidemiol	2013	24114802	Yes
2270	6105	1526.2	130.7	32.7	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
2271	1526	1526.0	44.8	44.8	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
2272	1525	1525.0	38.6	38.6	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
2273	1524	1524.0	19.2	19.2	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
2274	1524	1524.0	36.3	36.3	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2275	3046	1523.0	68.8	34.4	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Janicke	Cell Death Differ	1999	10200555	No
2276	3045	1522.5	95.3	47.6	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Backhed	Nature	2012	22972297	No
2277	4566	1522.0	97.6	32.5	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
2278	1522	1522.0	47.8	47.8	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
2279	1522	1522.0	25.3	25.3	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K FUXE	Acta Physiol Scand Suppl	1965	14319769	Yes
2280	3044	1522.0	71.3	35.6	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2281	1522	1522.0	43.3	43.3	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2282	1522	1522.0	38.9	38.9	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
2283	1520	1520.0	40.8	40.8	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
2284	3039	1519.5	84.9	42.5	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2285	3039	1519.5	94.1	47.0	CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data.	Jing Huang, Alexander D MacKerell	J Comput Chem	2013	23832629	Yes
2286	3038	1519.0	93.1	46.5	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
2287	1519	1519.0	50.5	50.5	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2288	1519	1519.0	29.1	29.1	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2289	3038	1519.0	83.7	41.9	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2290	4556	1518.7	261.1	87.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A WINTER, E A RISLEY, G W NUSS	Proc Soc Exp Biol Med	1962	14001233	Yes
2291	7588	1517.6	174.6	34.9	Jalview Version 2--a multiple sequence alignment editor and analysis workbench.	Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J Barton	Bioinformatics	2009	19151095	Yes
2292	1517	1517.0	37.8	37.8	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
2293	1517	1517.0	62.6	62.6	Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review.	Dariush Mozaffarian	Circulation	2016	26746178	No
2294	1516	1516.0	39.7	39.7	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
2295	3032	1516.0	101.3	50.6	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
2296	1515	1515.0	42.7	42.7	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
2297	1515	1515.0	30.8	30.8	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2298	1515	1515.0	40.4	40.4	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2299	1514	1514.0	43.8	43.8	The Danish Register of Causes of Death.	Karin Helweg-Larsen	Scand J Public Health	2011	21775346	Yes
2300	3027	1513.5	58.5	29.2	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
2301	3026	1513.0	75.7	37.9	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2302	3025	1512.5	62.0	31.0	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2303	1512	1512.0	63.6	63.6	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2304	1512	1512.0	46.8	46.8	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
2305	1512	1512.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B MOUNTCASTLE	J Neurophysiol	1957	13439410	Yes
2306	3023	1511.5	98.2	49.1	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
2307	4534	1511.3	100.1	33.4	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2308	4534	1511.3	187.7	62.6	Hepatocellular carcinoma.	Alejandro Forner, Maria Reig, Jordi Bruix	Lancet	2018	29307467	No
2309	1511	1511.0	34.6	34.6	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
2310	1511	1511.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
2311	1509	1509.0	38.1	38.1	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2312	1509	1509.0	45.9	45.9	Photoplethysmography and its application in clinical physiological measurement.	John Allen	Physiol Meas	2007	17322588	No
2313	3017	1508.5	150.9	75.5	Depression.	Gin S Malhi, J John Mann	Lancet	2018	30396512	No
2314	1508	1508.0	45.0	45.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
2315	1508	1508.0	33.5	33.5	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
2316	3015	1507.5	89.9	45.0	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2317	1507	1507.0	37.0	37.0	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
2318	1507	1507.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
2319	3013	1506.5	57.0	28.5	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2320	3013	1506.5	101.1	50.5	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
2321	18073	1506.1	1209.9	100.8	The REDCap consortium: Building an international community of software platform partners.	Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda,	J Biomed Inform	2019	31078660	Yes
2322	1506	1506.0	48.9	48.9	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
2323	1506	1506.0	25.7	25.7	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2324	1506	1506.0	38.0	38.0	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2325	3011	1505.5	0.0	0.0	Lactic dehydrogenase activity in blood.	F WROBLEWSKI, J S LADUE	Proc Soc Exp Biol Med	1955	13273400	Yes
2326	1505	1505.0	57.6	57.6	How does sexual minority stigma "get under the skin"? A psychological mediation framework.	Mark L Hatzenbuehler	Psychol Bull	2009	19702379	No
2327	1504	1504.0	32.9	32.9	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
2328	1504	1504.0	8.0	8.0	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W SPERRY	Proc Natl Acad Sci U S A	1963	14077501	Yes
2329	1504	1504.0	40.6	40.6	A comprehensive definition for metabolic syndrome.	Paul L Huang	Dis Model Mech	2009	19407331	No
2330	3007	1503.5	69.6	34.8	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2331	3007	1503.5	67.9	34.0	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2332	1503	1503.0	51.8	51.8	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2333	1503	1503.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E SATTERTHWAITE	Biometrics	1946	20287815	Yes
2334	3003	1501.5	79.1	39.5	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2335	3002	1501.0	101.4	50.7	Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression.	Christoph Hafemeister, Rahul Satija	Genome Biol	2019	31870423	Yes
2336	1500	1500.0	53.8	53.8	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2337	1500	1500.0	17.8	17.8	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
2338	1500	1500.0	43.6	43.6	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2339	1499	1499.0	52.2	52.2	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
2340	2997	1498.5	104.7	52.4	Kraken: ultrafast metagenomic sequence classification using exact alignments.	Derrick E Wood, Steven L Salzberg	Genome Biol	2014	24580807	Yes
2341	1498	1498.0	40.2	40.2	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
2342	1498	1498.0	52.2	52.2	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2343	1497	1497.0	36.2	36.2	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
2344	1497	1497.0	43.3	43.3	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
2345	1497	1497.0	32.0	32.0	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2346	2992	1496.0	153.2	76.6	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2347	1496	1496.0	38.5	38.5	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
2348	1496	1496.0	40.8	40.8	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Domling	Chem Rev	2006	16402771	No
2349	1495	1495.0	36.3	36.3	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
2350	2990	1495.0	63.9	31.9	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2351	1494	1494.0	39.2	39.2	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2352	1493	1493.0	54.8	54.8	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2353	2986	1493.0	58.9	29.4	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
2354	7463	1492.6	268.3	53.7	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2355	2984	1492.0	75.2	37.6	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
2356	1492	1492.0	33.8	33.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2357	1492	1492.0	50.3	50.3	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
2358	1491	1491.0	43.1	43.1	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
2359	1491	1491.0	53.8	53.8	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2360	1491	1491.0	0.0	0.0	The perceptron: a probabilistic model for information storage and organization in the brain.	F ROSENBLATT	Psychol Rev	1958	13602029	Yes
2361	1491	1491.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
2362	7451	1490.2	279.9	56.0	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
2363	4470	1490.0	45.9	15.3	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T DODGE, C MITCHELL, D J HANAHAN	Arch Biochem Biophys	1963	14028302	Yes
2364	1489	1489.0	39.0	39.0	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
2365	1489	1489.0	39.2	39.2	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
2366	1489	1489.0	30.6	30.6	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
2367	1489	1489.0	34.1	34.1	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2368	1489	1489.0	55.7	55.7	The variable nature of cognitive control: a dual mechanisms framework.	Todd S Braver	Trends Cogn Sci	2012	22245618	Yes
2369	4466	1488.7	160.3	53.4	Principles of nanoparticle design for overcoming biological barriers to drug delivery.	Elvin Blanco, Haifa Shen, Mauro Ferrari	Nat Biotechnol	2015	26348965	Yes
2370	2977	1488.5	73.2	36.6	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
2371	1487	1487.0	35.4	35.4	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2372	1487	1487.0	33.3	33.3	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
2373	5947	1486.8	253.0	63.2	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
2374	2972	1486.0	92.7	46.4	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2375	1486	1486.0	26.2	26.2	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
2376	1486	1486.0	48.2	48.2	Enhancing the quality and credibility of qualitative analysis.	M Q Patton	Health Serv Res	1999	10591279	No
2377	1486	1486.0	51.0	51.0	Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls?	Fay B Horak	Age Ageing	2006	16926210	No
2378	1486	1486.0	58.3	58.3	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2379	1486	1486.0	57.9	57.9	Diagnostic and Statistical Manual of Mental Disorders (DSM).	Dolores Elaine Battle	Codas	2013	24413388	Yes
2380	1485	1485.0	40.5	40.5	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
2381	1484	1484.0	35.3	35.3	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2382	2967	1483.5	68.1	34.0	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
2383	1483	1483.0	95.4	95.4	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
2384	1483	1483.0	31.0	31.0	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2385	1483	1483.0	95.0	95.0	A Review of Coronavirus Disease-2019 (COVID-19).	Tanu Singhal	Indian J Pediatr	2020	32166607	No
2386	23717	1482.3	629.8	39.4	New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).	E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij	Eur J Cancer	2009	19097774	No
2387	1482	1482.0	47.9	47.9	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2388	1482	1482.0	36.8	36.8	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2389	2964	1482.0	64.1	32.0	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2390	2963	1481.5	96.2	48.1	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
2391	1481	1481.0	86.7	86.7	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2392	1481	1481.0	10.7	10.7	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E HUXLEY	J Mol Biol	1963	14064165	Yes
2393	10364	1480.6	408.5	58.4	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2394	2961	1480.5	82.6	41.3	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2395	13323	1480.3	410.6	45.6	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
2396	4441	1480.3	95.7	31.9	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2397	4441	1480.3	93.8	31.3	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2398	1479	1479.0	34.4	34.4	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C NOWELL	Cancer Res	1960	14427849	Yes
2399	2957	1478.5	55.3	27.6	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
2400	2957	1478.5	82.1	41.0	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluisio J D Barros, Vania N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2401	1478	1478.0	43.8	43.8	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2402	2956	1478.0	58.5	29.2	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2403	1478	1478.0	36.7	36.7	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2404	1478	1478.0	33.8	33.8	What is a support vector machine?	William S Noble	Nat Biotechnol	2006	17160063	No
2405	4432	1477.3	95.4	31.8	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornoe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2406	2954	1477.0	68.0	34.0	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2407	1477	1477.0	31.5	31.5	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
2408	1476	1476.0	33.6	33.6	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
2409	1476	1476.0	38.4	38.4	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2410	1476	1476.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H ROSEN	Arch Biochem Biophys	1957	13412116	Yes
2411	2951	1475.5	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
2412	2948	1474.0	155.5	77.8	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G GRAY, V P WHITTAKER	J Anat	1962	13901297	Yes
2413	4421	1473.7	110.3	36.8	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2414	2947	1473.5	97.6	48.8	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2415	1473	1473.0	30.4	30.4	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
2416	1473	1473.0	56.4	56.4	The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study.	Natalie A de Morton	Aust J Physiother	2009	19463084	Yes
2417	1473	1473.0	43.1	43.1	The collagen family.	Sylvie Ricard-Blum	Cold Spring Harb Perspect Biol	2011	21421911	No
2418	1473	1473.0	51.5	51.5	The non-canonical NF-κB pathway in immunity and inflammation.	Shao-Cong Sun	Nat Rev Immunol	2017	28580957	No
2419	2945	1472.5	55.2	27.6	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2420	1472	1472.0	37.8	37.8	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2421	1471	1471.0	47.8	47.8	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
2422	1471	1471.0	51.9	51.9	The evolving concept of health literacy.	Don Nutbeam	Soc Sci Med	2008	18952344	Yes
2423	2941	1470.5	77.8	38.9	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
2424	1470	1470.0	32.9	32.9	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2425	1469	1469.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
2426	1468	1468.0	41.5	41.5	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2427	2936	1468.0	76.5	38.2	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2428	2936	1468.0	71.8	35.9	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2429	1468	1468.0	40.1	40.1	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2430	4402	1467.3	87.3	29.1	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2431	1467	1467.0	36.2	36.2	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
2432	1467	1467.0	67.9	67.9	SARS-CoV-2 vaccines in development.	Florian Krammer	Nature	2020	32967006	No
2433	2933	1466.5	85.0	42.5	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2434	1466	1466.0	20.8	20.8	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2435	1466	1466.0	25.9	25.9	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2436	1466	1466.0	44.2	44.2	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
2437	2932	1466.0	54.6	27.3	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2438	1466	1466.0	29.1	29.1	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2439	2931	1465.5	54.3	27.1	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2440	1465	1465.0	42.4	42.4	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2441	4394	1464.7	150.8	50.3	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2442	2929	1464.5	66.5	33.2	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2443	1464	1464.0	32.7	32.7	Simple methods for "staining with lead" at high pH in electron microscopy.	M J KARNOVSKY	J Biophys Biochem Cytol	1961	14454024	Yes
2444	1464	1464.0	45.8	45.8	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2445	4390	1463.3	89.6	29.9	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2446	2924	1462.0	68.2	34.1	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2447	7309	1461.8	205.1	41.0	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2448	1461	1461.0	34.3	34.3	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
2449	1461	1461.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E BUSH	Biochem J	1952	14915960	Yes
2450	2921	1460.5	75.8	37.9	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
2451	2920	1460.0	99.7	49.9	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
2452	1460	1460.0	41.4	41.4	Function and information content of DNA methylation.	Dirk Schubeler	Nature	2015	25592537	No
2453	2919	1459.5	105.5	52.8	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2454	2919	1459.5	117.2	58.6	Organic Photoredox Catalysis.	Nathan A Romero, David A Nicewicz	Chem Rev	2016	27285582	Yes
2455	1459	1459.0	39.0	39.0	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2456	1459	1459.0	47.3	47.3	Myeloid-Derived Suppressor Cells.	Dmitry I Gabrilovich	Cancer Immunol Res	2017	28052991	No
2457	2918	1459.0	88.6	44.3	Liquid phase condensation in cell physiology and disease.	Yongdae Shin, Clifford P Brangwynne	Science	2017	28935776	No
2458	1458	1458.0	31.5	31.5	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2459	4374	1458.0	115.9	38.6	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2460	2915	1457.5	85.6	42.8	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2461	1457	1457.0	40.5	40.5	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2462	1457	1457.0	53.7	53.7	How neuroinflammation contributes to neurodegeneration.	Richard M Ransohoff	Science	2016	27540165	No
2463	1457	1457.0	82.3	82.3	Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.	Jonas F Ludvigsson	Acta Paediatr	2020	32202343	Yes
2464	2913	1456.5	72.0	36.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
2465	2912	1456.0	62.6	31.3	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2466	2911	1455.5	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H CLARKE, J CASALS	Am J Trop Med Hyg	1958	13571577	Yes
2467	1455	1455.0	29.1	29.1	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
2468	1455	1455.0	39.7	39.7	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
2469	1455	1455.0	37.0	37.0	T follicular helper cell differentiation, function, and roles in disease.	Shane Crotty	Immunity	2014	25367570	No
2470	2909	1454.5	69.5	34.8	Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.	R P Rao, D H Ballard	Nat Neurosci	1999	10195184	Yes
2471	2909	1454.5	66.3	33.1	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gokhan S Hotamisligil	J Clin Invest	2005	15864338	No
2472	1454	1454.0	33.4	33.4	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
2473	1454	1454.0	35.0	35.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2474	1454	1454.0	27.6	27.6	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2475	2908	1454.0	37.0	18.5	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A DAHLSTROEM, K FUXE	Acta Physiol Scand Suppl	1964	14229500	Yes
2476	2907	1453.5	80.1	40.0	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2477	2907	1453.5	121.2	60.6	New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.	Anushka Dongre, Robert A Weinberg	Nat Rev Mol Cell Biol	2019	30459476	No
2478	4359	1453.0	109.4	36.5	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2479	8717	1452.8	214.4	35.7	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2480	4357	1452.3	203.8	67.9	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2481	1452	1452.0	43.0	43.0	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2482	1452	1452.0	31.1	31.1	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2483	4356	1452.0	112.4	37.5	Nitric oxide and peroxynitrite in health and disease.	Pal Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2484	2903	1451.5	59.7	29.9	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2485	1451	1451.0	17.1	17.1	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2486	1451	1451.0	30.9	30.9	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2487	2902	1451.0	79.3	39.6	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
2488	2902	1451.0	0.0	0.0	Virus interference. I. The interferon.	A ISAACS, J LINDENMANN	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2489	1451	1451.0	33.4	33.4	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2490	1451	1451.0	49.8	49.8	The biology and function of exosomes in cancer.	Raghu Kalluri	J Clin Invest	2016	27035812	No
2491	4351	1450.3	132.8	44.3	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2492	2900	1450.0	70.3	35.1	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
2493	2900	1450.0	84.7	42.4	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2494	2900	1450.0	85.9	43.0	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
2495	14494	1449.4	531.5	53.1	MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space.	Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck	Syst Biol	2012	22357727	Yes
2496	2898	1449.0	116.0	58.0	Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species.	R Vilgalys, M Hester	J Bacteriol	1990	2376561	Yes
2497	1449	1449.0	35.7	35.7	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2498	1449	1449.0	48.3	48.3	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
2499	1449	1449.0	29.4	29.4	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
2500	5796	1449.0	203.7	50.9	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2501	2897	1448.5	66.9	33.5	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2502	2896	1448.0	71.6	35.8	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2503	1448	1448.0	0.0	0.0	The critical incident technique.	J C FLANAGAN	Psychol Bull	1954	13177800	Yes
2504	1448	1448.0	40.7	40.7	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2505	5791	1447.8	151.3	37.8	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.	Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan	Nat Cell Biol	2011	21258367	Yes
2506	2895	1447.5	65.4	32.7	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
2507	2895	1447.5	154.9	77.5	Sarcopenia.	Alfonso J Cruz-Jentoft, Avan A Sayer	Lancet	2019	31171417	No
2508	2894	1447.0	78.3	39.1	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2509	5787	1446.8	153.3	38.3	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
2510	5787	1446.8	236.9	59.2	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2511	2893	1446.5	52.6	26.3	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2512	2893	1446.5	77.7	38.9	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2513	2892	1446.0	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J BLOOM, W W RICHARDSON	Br J Cancer	1957	13499785	Yes
2514	2892	1446.0	55.8	27.9	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
2515	1445	1445.0	58.8	58.8	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2516	2890	1445.0	69.6	34.8	The ubiquitin code.	David Komander, Michael Rape	Annu Rev Biochem	2012	22524316	No
2517	7225	1445.0	222.1	44.4	CD-HIT: accelerated for clustering the next-generation sequencing data.	Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li	Bioinformatics	2012	23060610	Yes
2518	2889	1444.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D DAVIS, E S MINGIOLI	J Bacteriol	1950	15436457	Yes
2519	1444	1444.0	67.6	67.6	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2520	2887	1443.5	70.2	35.1	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2521	1443	1443.0	36.9	36.9	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
2522	1443	1443.0	54.4	54.4	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2523	1443	1443.0	30.5	30.5	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2524	8657	1442.8	208.6	34.8	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2525	1441	1441.0	50.5	50.5	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2526	1441	1441.0	34.4	34.4	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2527	2881	1440.5	175.1	87.5	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H ANTON, D F SAYRE	J Pharmacol Exp Ther	1962	14013351	Yes
2528	2880	1440.0	70.2	35.1	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2529	1440	1440.0	26.7	26.7	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
2530	2880	1440.0	58.6	29.3	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2531	1439	1439.0	29.6	29.6	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2532	1438	1438.0	40.4	40.4	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2533	1438	1438.0	39.8	39.8	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2534	2875	1437.5	66.6	33.3	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2535	4312	1437.3	93.1	31.0	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2536	1437	1437.0	31.9	31.9	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2537	1437	1437.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D POULIK	Nature	1957	13493570	Yes
2538	1437	1437.0	16.6	16.6	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J WYMAN	Adv Protein Chem	1964	14268785	No
2539	8619	1436.5	299.2	49.9	Second-generation PLINK: rising to the challenge of larger and richer datasets.	Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee	Gigascience	2015	25722852	Yes
2540	7182	1436.4	154.1	30.8	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
2541	1436	1436.0	35.3	35.3	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2542	17229	1435.8	429.0	35.8	Frailty in older adults: evidence for a phenotype.	L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie,	J Gerontol A Biol Sci Med Sci	2001	11253156	Yes
2543	1435	1435.0	33.7	33.7	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
2544	1435	1435.0	29.6	29.6	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2545	2867	1433.5	52.9	26.4	STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.	Hiroki Ishikawa, Glen N Barber	Nature	2008	18724357	Yes
2546	1433	1433.0	46.0	46.0	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
2547	2866	1433.0	106.7	53.4	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
2548	1433	1433.0	28.0	28.0	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2549	2866	1433.0	69.7	34.9	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2550	1433	1433.0	40.5	40.5	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2551	4298	1432.7	90.9	30.3	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
2552	4297	1432.3	99.2	33.1	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2553	8593	1432.2	250.2	41.7	Prodigal: prokaryotic gene recognition and translation initiation site identification.	Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser	BMC Bioinformatics	2010	20211023	Yes
2554	1432	1432.0	32.6	32.6	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
2555	1432	1432.0	45.5	45.5	Starting at the beginning: an introduction to coefficient alpha and internal consistency.	David L Streiner	J Pers Assess	2003	12584072	Yes
2556	1432	1432.0	32.9	32.9	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2557	2864	1432.0	78.9	39.5	Relaxing the rule of ten events per variable in logistic and Cox regression.	Eric Vittinghoff, Charles E McCulloch	Am J Epidemiol	2007	17182981	Yes
2558	1432	1432.0	12.9	12.9	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
2559	1432	1432.0	44.2	44.2	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2560	1432	1432.0	67.4	67.4	The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety.	Martins Ekor	Front Pharmacol	2014	24454289	No
2561	4294	1431.3	139.8	46.6	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2562	1431	1431.0	37.2	37.2	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2563	8584	1430.7	222.2	37.0	Genome engineering using the CRISPR-Cas9 system.	F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang	Nat Protoc	2013	24157548	Yes
2564	2861	1430.5	83.1	41.5	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2565	2859	1429.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L HODGKIN, B KATZ	J Physiol	1949	18128147	Yes
2566	1429	1429.0	41.7	41.7	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2567	1429	1429.0	28.0	28.0	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2568	2857	1428.5	95.7	47.9	A new scale of social desirability independent of psychopathology.	D P CROWNE, D MARLOWE	J Consult Psychol	1960	13813058	Yes
2569	2855	1427.5	77.7	38.9	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2570	2855	1427.5	81.2	40.6	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2571	1427	1427.0	33.1	33.1	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
2572	2853	1426.5	69.5	34.8	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2573	2853	1426.5	74.1	37.0	New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.	Jonathan B Baell, Georgina A Holloway	J Med Chem	2010	20131845	Yes
2574	1426	1426.0	29.3	29.3	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2575	5704	1426.0	191.3	47.8	Predicting effective microRNA target sites in mammalian mRNAs.	Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel	Elife	2015	26267216	Yes
2576	5702	1425.5	142.0	35.5	Organometal halide perovskites as visible-light sensitizers for photovoltaic cells.	Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka	J Am Chem Soc	2009	19366264	Yes
2577	1425	1425.0	41.4	41.4	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2578	2850	1425.0	172.8	86.4	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2579	1425	1425.0	15.5	15.5	Central dogma of molecular biology.	F Crick	Nature	1970	4913914	No
2580	1425	1425.0	48.9	48.9	Plasma perspective on strong field multiphoton ionization.	P B Corkum	Phys Rev Lett	1993	10054556	Yes
2581	1425	1425.0	26.8	26.8	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2582	2850	1425.0	66.6	33.3	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2583	1424	1424.0	35.5	35.5	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2584	2847	1423.5	88.8	44.4	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
2585	9963	1423.3	289.3	41.3	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
2586	1423	1423.0	31.4	31.4	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2587	2846	1423.0	64.6	32.3	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2588	1423	1423.0	25.3	25.3	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
2589	1423	1423.0	64.8	64.8	Patient reported outcome measures could help transform healthcare.	Nick Black	BMJ	2013	23358487	Yes
2590	1423	1423.0	67.6	67.6	Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.	Nicholas A Meanwell	J Med Chem	2018	29400967	No
2591	2845	1422.5	97.4	48.7	Unique features of long non-coding RNA biogenesis and function.	Jeffrey J Quinn, Howard Y Chang	Nat Rev Genet	2016	26666209	No
2592	2845	1422.5	83.2	41.6	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2593	1422	1422.0	31.2	31.2	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2594	1422	1422.0	38.8	38.8	The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.	R G Pertwee	Br J Pharmacol	2008	17828291	No
2595	1421	1421.0	24.4	24.4	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2596	5682	1420.5	143.0	35.8	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw,	Lancet	2005	16182882	Yes
2597	4261	1420.3	220.0	73.3	Improved metagenomic analysis with Kraken 2.	Derrick E Wood, Jennifer Lu, Ben Langmead	Genome Biol	2019	31779668	Yes
2598	1420	1420.0	32.7	32.7	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2599	2839	1419.5	107.1	53.5	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2600	2839	1419.5	62.6	31.3	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2601	2838	1419.0	82.5	41.2	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2602	1419	1419.0	36.1	36.1	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2603	1418	1418.0	70.1	70.1	Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges.	Dimitrios Tsikas	Anal Biochem	2017	27789233	No
2604	4252	1417.3	117.0	39.0	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2605	1417	1417.0	50.7	50.7	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
2606	1417	1417.0	25.1	25.1	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
2607	1417	1417.0	36.1	36.1	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2608	1417	1417.0	52.9	52.9	Likert scales, levels of measurement and the "laws" of statistics.	Geoff Norman	Adv Health Sci Educ Theory Pract	2010	20146096	Yes
2609	2833	1416.5	103.0	51.5	Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.	Ulrich M Zanger, Matthias Schwab	Pharmacol Ther	2013	23333322	No
2610	1416	1416.0	33.2	33.2	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2611	1416	1416.0	31.1	31.1	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2612	1415	1415.0	25.3	25.3	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2613	4245	1415.0	94.3	31.4	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2614	2829	1414.5	98.3	49.1	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2615	2829	1414.5	63.1	31.6	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2616	5658	1414.5	264.0	66.0	The Cambridge Structural Database.	Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward	Acta Crystallogr B Struct Sci Cryst Eng Mater	2016	27048719	Yes
2617	7071	1414.2	132.1	26.4	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mader, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2618	2828	1414.0	56.0	28.0	Learning the parts of objects by non-negative matrix factorization.	D D Lee, H S Seung	Nature	1999	10548103	Yes
2619	4242	1414.0	80.3	26.8	Exosomes: composition, biogenesis and function.	Clotilde Thery, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
2620	1414	1414.0	29.6	29.6	Simple model of spiking neurons.	E M Izhikevich	IEEE Trans Neural Netw	2003	18244602	Yes
2621	4241	1413.7	84.6	28.2	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2622	2826	1413.0	71.1	35.5	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2623	2826	1413.0	42.4	21.2	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2624	1413	1413.0	43.5	43.5	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2625	1413	1413.0	32.0	32.0	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2626	1413	1413.0	35.4	35.4	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2627	7062	1412.4	247.5	49.5	The Phyre2 web portal for protein modeling, prediction and analysis.	Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg	Nat Protoc	2015	25950237	Yes
2628	2824	1412.0	71.5	35.8	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2629	2824	1412.0	100.7	50.4	AKT/PKB Signaling: Navigating the Network.	Brendan D Manning, Alex Toker	Cell	2017	28431241	No
2630	4234	1411.3	85.0	28.3	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
2631	1411	1411.0	35.5	35.5	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2632	2821	1410.5	78.9	39.5	Mitochondrial fission, fusion, and stress.	Richard J Youle, Alexander M van der Bliek	Science	2012	22936770	No
2633	2820	1410.0	128.7	64.3	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2634	2820	1410.0	95.1	47.5	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2635	1410	1410.0	29.1	29.1	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2636	1410	1410.0	31.6	31.6	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2637	1410	1410.0	34.2	34.2	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2638	1410	1410.0	28.1	28.1	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Sudhof	Nature	2008	18923512	No
2639	2819	1409.5	82.8	41.4	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2640	2818	1409.0	0.0	0.0	Construct validity in psychological tests.	L J CRONBACH, P E MEEHL	Psychol Bull	1955	13245896	Yes
2641	1408	1408.0	21.3	21.3	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2642	1407	1407.0	32.5	32.5	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2643	1407	1407.0	28.8	28.8	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2644	4220	1406.7	106.4	35.5	Cognitive and emotional influences in anterior cingulate cortex.	G Bush, P Luu, M I Posner	Trends Cogn Sci	2000	10827444	Yes
2645	2813	1406.5	84.1	42.0	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2646	2813	1406.5	80.9	40.5	Opportunities and challenges for a sustainable energy future.	Steven Chu, Arun Majumdar	Nature	2012	22895334	No
2647	1406	1406.0	31.7	31.7	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2648	1406	1406.0	37.0	37.0	Core affect and the psychological construction of emotion.	James A Russell	Psychol Rev	2003	12529060	No
2649	4218	1406.0	96.1	32.0	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2650	2811	1405.5	74.8	37.4	Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis.	J A Sterne, M Egger	J Clin Epidemiol	2001	11576817	Yes
2651	2811	1405.5	61.6	30.8	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2652	1405	1405.0	73.3	73.3	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2653	2809	1404.5	92.5	46.2	Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.	Claudio Franceschi, Judith Campisi	J Gerontol A Biol Sci Med Sci	2014	24833586	No
2654	4212	1404.0	119.8	39.9	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
2655	1403	1403.0	46.8	46.8	Electrolytes and interphases in Li-ion batteries and beyond.	Kang Xu	Chem Rev	2014	25351820	Yes
2656	1402	1402.0	29.6	29.6	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2657	1402	1402.0	34.3	34.3	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2658	1402	1402.0	32.7	32.7	Hydrogen sulphide and its therapeutic potential.	Csaba Szabo	Nat Rev Drug Discov	2007	17948022	No
2659	1402	1402.0	36.7	36.7	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2660	1402	1402.0	43.3	43.3	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2661	1401	1401.0	39.1	39.1	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2662	1401	1401.0	40.9	40.9	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
2663	2800	1400.0	86.4	43.2	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2664	1400	1400.0	50.5	50.5	A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading.	Cathy J Price	Neuroimage	2012	22584224	No
2665	6996	1399.2	185.7	37.1	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2666	1399	1399.0	22.2	22.2	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2667	2797	1398.5	71.2	35.6	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2668	5593	1398.2	119.4	29.9	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2669	1398	1398.0	42.9	42.9	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2670	1398	1398.0	11.0	11.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2671	2796	1398.0	61.8	30.9	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2672	1397	1397.0	40.9	40.9	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2673	1397	1397.0	37.1	37.1	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2674	1397	1397.0	35.8	35.8	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2675	1396	1396.0	30.7	30.7	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2676	2792	1396.0	81.5	40.8	Microdetermination of long-chain fatty acids in plasma and tissues.	V P DOLE, H MEINERTZ	J Biol Chem	1960	13817286	Yes
2677	1396	1396.0	59.0	59.0	Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.	Helmut Sies	Redox Biol	2017	28110218	No
2678	5582	1395.5	150.3	37.6	GCTA: a tool for genome-wide complex trait analysis.	Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher	Am J Hum Genet	2011	21167468	Yes
2679	1395	1395.0	30.9	30.9	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2680	2790	1395.0	61.6	30.8	Immunoassay of endogenous plasma insulin in man.	R S YALOW, S A BERSON	J Clin Invest	1960	13846364	Yes
2681	1395	1395.0	25.6	25.6	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2682	1395	1395.0	45.2	45.2	The frailty syndrome: definition and natural history.	Qian-Li Xue	Clin Geriatr Med	2011	21093718	No
2683	1394	1394.0	45.9	45.9	Energy metabolism in the liver.	Liangyou Rui	Compr Physiol	2014	24692138	No
2684	2787	1393.5	100.6	50.3	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2685	1393	1393.0	28.3	28.3	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2686	2786	1393.0	59.8	29.9	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2687	1392	1392.0	49.6	49.6	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2688	1392	1392.0	26.2	26.2	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2689	4176	1392.0	101.0	33.7	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon,	J Thromb Haemost	2005	15842354	Yes
2690	2783	1391.5	81.3	40.6	Mechanisms of fibrosis: therapeutic translation for fibrotic disease.	Thomas A Wynn, Thirumalai R Ramalingam	Nat Med	2012	22772564	No
2691	1391	1391.0	29.6	29.6	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2692	1390	1390.0	61.2	61.2	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2693	1390	1390.0	32.3	32.3	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2694	1390	1390.0	34.9	34.9	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2695	1390	1390.0	79.2	79.2	Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry.	Janice M Morse	Qual Health Res	2015	26184336	Yes
2696	1390	1390.0	61.8	61.8	Body Mass Index: Obesity, BMI, and Health: A Critical Review.	Frank Q Nuttall	Nutr Today	2015	27340299	Yes
2697	4165	1388.3	86.0	28.7	Computer visualization of three-dimensional image data using IMOD.	J R Kremer, D N Mastronarde, J R McIntosh	J Struct Biol	1996	8742726	Yes
2698	1388	1388.0	43.4	43.4	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2699	1388	1388.0	0.0	0.0	Comparing individual means in the analysis of variance.	J W TUKEY	Biometrics	1949	18151955	Yes
2700	2776	1388.0	116.4	58.2	Principal component analysis: a review and recent developments.	Ian T Jolliffe, Jorge Cadima	Philos Trans A Math Phys Eng Sci	2016	26953178	No
2701	1387	1387.0	24.0	24.0	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2702	2774	1387.0	54.8	27.4	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2703	1387	1387.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M REITAN	J Consult Psychol	1955	13263471	Yes
2704	1387	1387.0	23.7	23.7	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2705	1386	1386.0	36.6	36.6	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2706	2772	1386.0	67.5	33.8	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2707	2770	1385.0	71.2	35.6	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
2708	1385	1385.0	39.1	39.1	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2709	1385	1385.0	27.4	27.4	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2710	1385	1385.0	31.9	31.9	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2711	4153	1384.3	147.7	49.2	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2712	4153	1384.3	90.1	30.0	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2713	2768	1384.0	165.1	82.5	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2714	2766	1383.0	76.8	38.4	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2715	1383	1383.0	31.2	31.2	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2716	1383	1383.0	55.6	55.6	Overview of the IL-1 family in innate inflammation and acquired immunity.	Charles A Dinarello	Immunol Rev	2018	29247995	No
2717	2765	1382.5	99.3	49.6	MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets.	Martin Steinegger, Johannes Soding	Nat Biotechnol	2017	29035372	Yes
2718	1382	1382.0	36.1	36.1	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2719	1382	1382.0	36.2	36.2	Atomic layer deposition: an overview.	Steven M George	Chem Rev	2010	19947596	Yes
2720	1382	1382.0	62.4	62.4	Embracing the unknown: disentangling the complexities of the soil microbiome.	Noah Fierer	Nat Rev Microbiol	2017	28824177	No
2721	1381	1381.0	0.0	0.0	On the psychophysical law.	S S STEVENS	Psychol Rev	1957	13441853	Yes
2722	1381	1381.0	11.5	11.5	Immunological function of the thymus.	J F MILLER	Lancet	1961	14474038	Yes
2723	1381	1381.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C SCHNEIDER	J Biol Chem	1948	18886166	Yes
2724	2761	1380.5	70.4	35.2	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
2725	2760	1380.0	96.4	48.2	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2726	1380	1380.0	28.3	28.3	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2727	1380	1380.0	32.1	32.1	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2728	4140	1380.0	99.9	33.3	Improved vectors and genome-wide libraries for CRISPR screening.	Neville E Sanjana, Ophir Shalem, Feng Zhang	Nat Methods	2014	25075903	Yes
2729	2759	1379.5	55.2	27.6	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2730	1379	1379.0	23.9	23.9	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
2731	2758	1379.0	70.3	35.1	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wuthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2732	2758	1379.0	118.9	59.5	Inflammation and Cancer: Triggers, Mechanisms, and Consequences.	Florian R Greten, Sergei I Grivennikov	Immunity	2019	31315034	No
2733	1378	1378.0	33.3	33.3	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2734	2755	1377.5	60.1	30.1	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
2735	1377	1377.0	47.8	47.8	Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.	K Tamura	Mol Biol Evol	1992	1630306	Yes
2736	1377	1377.0	39.1	39.1	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2737	1377	1377.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B CLOWARD	J Neurosurg	1958	13599052	Yes
2738	2754	1377.0	86.7	43.4	A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.	Walter J Paulus, Carsten Tschope	J Am Coll Cardiol	2013	23684677	No
2739	1377	1377.0	80.3	80.3	COVID-19 and African Americans.	Clyde W Yancy	JAMA	2020	32293639	Yes
2740	2752	1376.0	70.0	35.0	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2741	8256	1376.0	202.8	33.8	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2742	1375	1375.0	43.5	43.5	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2743	1375	1375.0	63.9	63.9	Systematic text condensation: a strategy for qualitative analysis.	Kirsti Malterud	Scand J Public Health	2012	23221918	Yes
2744	2749	1374.5	66.6	33.3	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2745	1374	1374.0	22.8	22.8	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2746	1374	1374.0	34.5	34.5	Time is brain--quantified.	Jeffrey L Saver	Stroke	2006	16339467	Yes
2747	1374	1374.0	44.9	44.9	Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms.	Tamas Roszer	Mediators Inflamm	2015	26089604	No
2748	9615	1373.6	597.9	85.4	IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era.	Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert Lanfear	Mol Biol Evol	2020	32011700	Yes
2749	1373	1373.0	48.2	48.2	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2750	1373	1373.0	42.0	42.0	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2751	1373	1373.0	27.3	27.3	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2752	1373	1373.0	35.4	35.4	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2753	8233	1372.2	227.3	37.9	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2754	1372	1372.0	32.8	32.8	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
2755	1372	1372.0	36.4	36.4	The stress response to trauma and surgery.	J P Desborough	Br J Anaesth	2000	10927999	No
2756	4115	1371.7	250.3	83.4	How to perform a meta-analysis with R: a practical tutorial.	Sara Balduzzi, Gerta Rucker, Guido Schwarzer	Evid Based Ment Health	2019	31563865	Yes
2757	2743	1371.5	54.2	27.1	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
2758	2743	1371.5	53.7	26.9	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
2759	2743	1371.5	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B CHANCE, G R WILLIAMS	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
2760	4113	1371.0	95.3	31.8	Prediction of total genetic value using genome-wide dense marker maps.	T H Meuwissen, B J Hayes, M E Goddard	Genetics	2001	11290733	Yes
2761	1371	1371.0	28.7	28.7	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2762	5484	1371.0	105.6	26.4	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2763	1371	1371.0	43.6	43.6	Mediators and mechanisms of change in psychotherapy research.	Alan E Kazdin	Annu Rev Clin Psychol	2007	17716046	No
2764	1371	1371.0	60.7	60.7	The new statistics: why and how.	Geoff Cumming	Psychol Sci	2014	24220629	Yes
2765	4110	1370.0	121.9	40.6	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2766	5480	1370.0	124.6	31.1	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2767	5477	1369.2	172.2	43.0	Validation of a combined comorbidity index.	M Charlson, T P Szatrowski, J Peterson, J Gold	J Clin Epidemiol	1994	7722560	Yes
2768	5477	1369.2	162.6	40.6	Epidemiology and causes of preterm birth.	Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero	Lancet	2008	18177778	No
2769	2738	1369.0	56.2	28.1	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
2770	1369	1369.0	46.2	46.2	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
2771	4107	1369.0	126.0	42.0	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2772	2737	1368.5	75.7	37.9	Accurate and robust brain image alignment using boundary-based registration.	Douglas N Greve, Bruce Fischl	Neuroimage	2009	19573611	Yes
2773	1368	1368.0	27.4	27.4	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
2774	2736	1368.0	73.0	36.5	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2775	2734	1367.0	39.9	19.9	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2776	1367	1367.0	33.8	33.8	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2777	5467	1366.8	116.7	29.2	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2778	1366	1366.0	38.2	38.2	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2779	1366	1366.0	45.1	45.1	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2780	1366	1366.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O SMITHIES	Biochem J	1959	13638269	Yes
2781	1366	1366.0	29.7	29.7	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2782	1366	1366.0	35.2	35.2	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2783	2732	1366.0	102.9	51.5	Functional Classification and Experimental Dissection of Long Noncoding RNAs.	Florian Kopp, Joshua T Mendell	Cell	2018	29373828	No
2784	2731	1365.5	88.5	44.2	Severe sepsis and septic shock.	Derek C Angus, Tom van der Poll	N Engl J Med	2013	23984731	No
2785	1364	1364.0	46.6	46.6	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2786	1364	1364.0	23.3	23.3	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2787	5455	1363.8	308.8	77.2	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
2788	5455	1363.8	234.5	58.6	Genome sequence-based species delimitation with confidence intervals and improved distance functions.	Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Goker	BMC Bioinformatics	2013	23432962	Yes
2789	13626	1362.6	467.1	46.7	The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.	Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher	BMJ	2009	19622552	No
2790	1362	1362.0	23.2	23.2	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2791	2724	1362.0	121.8	60.9	An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging.	Jesper L R Andersson, Stamatios N Sotiropoulos	Neuroimage	2016	26481672	Yes
2792	1362	1362.0	44.2	44.2	The biogenesis and emerging roles of circular RNAs.	Ling-Ling Chen	Nat Rev Mol Cell Biol	2016	26908011	Yes
2793	1361	1361.0	41.7	41.7	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2794	1361	1361.0	41.1	41.1	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2795	1361	1361.0	48.5	48.5	The case for motivated reasoning.	Z Kunda	Psychol Bull	1990	2270237	No
2796	1361	1361.0	57.9	57.9	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
2797	1361	1361.0	56.0	56.0	Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1.	Daniel J Drucker	Cell Metab	2018	29617641	No
2798	2721	1360.5	56.4	28.2	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2799	1360	1360.0	28.4	28.4	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2800	1360	1360.0	42.3	42.3	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2801	1360	1360.0	53.1	53.1	The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review.	Erik G Willcutt	Neurotherapeutics	2012	22976615	Yes
2802	2719	1359.5	120.5	60.2	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2803	5438	1359.5	124.3	31.1	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2804	2718	1359.0	72.1	36.0	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2805	1359	1359.0	43.2	43.2	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2806	1359	1359.0	36.4	36.4	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2807	2718	1359.0	47.2	23.6	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2808	2718	1359.0	52.6	26.3	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2809	2718	1359.0	81.8	40.9	Central sensitization: a generator of pain hypersensitivity by central neural plasticity.	Alban Latremoliere, Clifford J Woolf	J Pain	2009	19712899	No
2810	2717	1358.5	135.4	67.7	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2811	1358	1358.0	66.4	66.4	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2812	1358	1358.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B CAULFIELD	J Biophys Biochem Cytol	1957	13475399	Yes
2813	2715	1357.5	69.0	34.5	Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis).	S M Rogers, L Bernatchez	Mol Ecol	2005	15660930	Yes
2814	2715	1357.5	94.6	47.3	Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.	Mercedes Tkach, Clotilde Thery	Cell	2016	26967288	No
2815	1357	1357.0	26.9	26.9	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2816	2714	1357.0	74.6	37.3	Type 2 diabetes as an inflammatory disease.	Marc Y Donath, Steven E Shoelson	Nat Rev Immunol	2011	21233852	No
2817	1357	1357.0	44.3	44.3	The pathobiology of vascular dementia.	Costantino Iadecola	Neuron	2013	24267647	No
2818	1356	1356.0	34.2	34.2	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2819	1356	1356.0	63.5	63.5	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
2820	4068	1356.0	100.2	33.4	Atomic force microscope.	G Binnig, C F Quate, C Gerber	Phys Rev Lett	1986	10033323	Yes
2821	1356	1356.0	29.5	29.5	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2822	1356	1356.0	24.3	24.3	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2823	1356	1356.0	32.8	32.8	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2824	1356	1356.0	39.5	39.5	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2825	2711	1355.5	90.7	45.4	Inflammasomes: mechanism of assembly, regulation and signalling.	Petr Broz, Vishva M Dixit	Nat Rev Immunol	2016	27291964	No
2826	1355	1355.0	35.0	35.0	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
2827	1355	1355.0	46.0	46.0	Visual attention: the past 25 years.	Marisa Carrasco	Vision Res	2011	21549742	No
2828	5419	1354.8	119.5	29.9	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2829	2709	1354.5	220.4	110.2	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2830	2709	1354.5	57.5	28.8	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2831	1354	1354.0	35.4	35.4	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2832	1354	1354.0	33.5	33.5	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2833	4062	1354.0	49.7	16.6	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D SABATINI, K BENSCH, R J BARRNETT	J Cell Biol	1963	13975866	Yes
2834	1353	1353.0	48.3	48.3	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2835	1353	1353.0	25.8	25.8	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2836	2706	1353.0	64.1	32.0	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2837	2706	1353.0	59.1	29.6	Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission.	P van den Driessche, James Watmough	Math Biosci	2002	12387915	Yes
2838	1353	1353.0	53.6	53.6	Mediation Analysis: A Practitioner's Guide.	Tyler J VanderWeele	Annu Rev Public Health	2016	26653405	No
2839	2705	1352.5	60.6	30.3	Reducing the dimensionality of data with neural networks.	G E Hinton, R R Salakhutdinov	Science	2006	16873662	Yes
2840	4057	1352.3	126.7	42.2	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2841	12170	1352.2	292.1	32.5	MolProbity: all-atom structure validation for macromolecular crystallography.	Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson	Acta Crystallogr D Biol Crystallogr	2010	20057044	Yes
2842	2704	1352.0	61.1	30.6	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2843	1352	1352.0	35.3	35.3	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2844	2702	1351.0	68.3	34.1	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2845	1351	1351.0	35.8	35.8	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
2846	5404	1351.0	147.9	37.0	Biological identifications through DNA barcodes.	Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard	Proc Biol Sci	2003	12614582	Yes
2847	1350	1350.0	44.1	44.1	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2848	1350	1350.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J WADDELL	J Lab Clin Med	1956	13346201	Yes
2849	14846	1349.6	405.4	36.9	International physical activity questionnaire: 12-country reliability and validity.	Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja	Med Sci Sports Exerc	2003	12900694	Yes
2850	10797	1349.6	260.0	32.5	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
2851	2699	1349.5	60.8	30.4	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
2852	4048	1349.3	196.5	65.5	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
2853	1349	1349.0	17.0	17.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2854	2698	1349.0	73.1	36.5	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2855	1349	1349.0	30.4	30.4	Correlates of protection induced by vaccination.	Stanley A Plotkin	Clin Vaccine Immunol	2010	20463105	No
2856	2698	1349.0	113.6	56.8	Activation of apoptosis signalling pathways by reactive oxygen species.	Maureen Redza-Dutordoir, Diana A Averill-Bates	Biochim Biophys Acta	2016	27646922	No
2857	2697	1348.5	56.0	28.0	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2858	2697	1348.5	58.7	29.4	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2859	2696	1348.0	60.5	30.2	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2860	1348	1348.0	28.0	28.0	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2861	2696	1348.0	65.8	32.9	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2862	2695	1347.5	75.0	37.5	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gokhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
2863	1346	1346.0	27.3	27.3	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2864	2691	1345.5	86.4	43.2	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
2865	4035	1345.0	165.8	55.3	Measurement of health status. Ascertaining the minimal clinically important difference.	R Jaeschke, J Singer, G H Guyatt	Control Clin Trials	1989	2691207	Yes
2866	1345	1345.0	38.6	38.6	Cognitive and affective development in adolescence.	Laurence Steinberg	Trends Cogn Sci	2005	15668099	No
2867	4035	1345.0	93.1	31.0	METAL: fast and efficient meta-analysis of genomewide association scans.	Cristen J Willer, Yun Li, Goncalo R Abecasis	Bioinformatics	2010	20616382	Yes
2868	2689	1344.5	44.9	22.4	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2869	1344	1344.0	55.7	55.7	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2870	1344	1344.0	45.4	45.4	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2871	1344	1344.0	30.9	30.9	Immortal time bias in pharmaco-epidemiology.	Samy Suissa	Am J Epidemiol	2008	18056625	No
2872	10749	1343.6	455.7	57.0	Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.	Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda	Nat Commun	2019	30944313	Yes
2873	4030	1343.3	89.3	29.8	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2874	2686	1343.0	61.5	30.8	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
2875	8058	1343.0	228.7	38.1	The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis.	A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager	Cogn Psychol	2000	10945922	Yes
2876	1342	1342.0	51.6	51.6	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
2877	2683	1341.5	69.0	34.5	A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions.	Yan Zhao, Donald G Truhlar	J Chem Phys	2006	17129083	Yes
2878	1341	1341.0	35.5	35.5	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2879	1341	1341.0	32.3	32.3	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2880	2682	1341.0	78.4	39.2	The reward circuit: linking primate anatomy and human imaging.	Suzanne N Haber, Brian Knutson	Neuropsychopharmacology	2010	19812543	No
2881	4022	1340.7	95.2	31.7	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2882	1340	1340.0	46.5	46.5	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2883	1340	1340.0	30.1	30.1	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2884	1340	1340.0	42.4	42.4	Stochastic thermodynamics, fluctuation theorems and molecular machines.	Udo Seifert	Rep Prog Phys	2012	23168354	No
2885	4018	1339.3	120.8	40.3	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2886	4018	1339.3	92.6	30.9	Astrocyte-endothelial interactions at the blood-brain barrier.	N Joan Abbott, Lars Ronnback, Elisabeth Hansson	Nat Rev Neurosci	2006	16371949	No
2887	8036	1339.3	280.9	46.8	ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB.	James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling	J Chem Theory Comput	2015	26574453	Yes
2888	5357	1339.2	133.0	33.2	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2889	1339	1339.0	35.0	35.0	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2890	1339	1339.0	46.5	46.5	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
2891	1338	1338.0	54.9	54.9	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2892	1338	1338.0	30.1	30.1	Targeting DNA topoisomerase II in cancer chemotherapy.	John L Nitiss	Nat Rev Cancer	2009	19377506	No
2893	2675	1337.5	57.9	28.9	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2894	1337	1337.0	24.8	24.8	A modified procedure for lead staining of thin sections.	G MILLONIG	J Biophys Biochem Cytol	1961	14474176	Yes
2895	2674	1337.0	62.1	31.1	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2896	1337	1337.0	36.0	36.0	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
2897	1337	1337.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A BERG	J Gen Psychol	1948	18889466	Yes
2898	9354	1336.3	263.9	37.7	pROC: an open-source package for R and S+ to analyze and compare ROC curves.	Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus Muller	BMC Bioinformatics	2011	21414208	Yes
2899	6681	1336.2	306.9	61.4	Using the framework method for the analysis of qualitative data in multi-disciplinary health research.	Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood	BMC Med Res Methodol	2013	24047204	Yes
2900	2672	1336.0	79.3	39.6	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
2901	1336	1336.0	36.5	36.5	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2902	1336	1336.0	32.6	32.6	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2903	2672	1336.0	57.1	28.6	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2904	2672	1336.0	112.4	56.2	The role of inflammation in depression: from evolutionary imperative to modern treatment target.	Andrew H Miller, Charles L Raison	Nat Rev Immunol	2016	26711676	No
2905	2670	1335.0	49.5	24.8	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2906	1335	1335.0	24.5	24.5	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
2907	1335	1335.0	29.9	29.9	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2908	2670	1335.0	64.5	32.2	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2909	2670	1335.0	66.9	33.5	Humans integrate visual and haptic information in a statistically optimal fashion.	Marc O Ernst, Martin S Banks	Nature	2002	11807554	Yes
2910	1335	1335.0	26.9	26.9	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2911	1335	1335.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J BATEMAN	Heredity (Edinb)	1948	18103134	Yes
2912	2669	1334.5	100.3	50.1	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
2913	2669	1334.5	91.3	45.6	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2914	2669	1334.5	52.2	26.1	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2915	1334	1334.0	33.7	33.7	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2916	1334	1334.0	27.2	27.2	The advantages and disadvantages of being polyploid.	Luca Comai	Nat Rev Genet	2005	16304599	No
2917	1334	1334.0	30.0	30.0	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2918	2667	1333.5	79.7	39.9	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2919	1333	1333.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J BERKSON	Biometrics	1946	21001024	Yes
2920	1332	1332.0	56.0	56.0	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2921	1332	1332.0	50.7	50.7	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2922	1332	1332.0	31.8	31.8	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2923	1332	1332.0	328.9	328.9	A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn.	Tian Lu	J Chem Phys	2024	39189657	Yes
2924	3994	1331.3	111.6	37.2	HMMER web server: interactive sequence similarity searching.	Robert D Finn, Jody Clements, Sean R Eddy	Nucleic Acids Res	2011	21593126	Yes
2925	1331	1331.0	17.9	17.9	The nature and significance of platelet products in human plasma.	P Wolf	Br J Haematol	1967	6025241	Yes
2926	1331	1331.0	22.0	22.0	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2927	5320	1330.0	129.7	32.4	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2928	1330	1330.0	31.8	31.8	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
2929	1330	1330.0	34.6	34.6	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2930	1330	1330.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2931	1330	1330.0	37.8	37.8	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2932	2660	1330.0	76.3	38.1	Crosstalk of reactive oxygen species and NF-κB signaling.	Michael J Morgan, Zheng-gang Liu	Cell Res	2011	21187859	No
2933	2659	1329.5	50.5	25.2	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2934	1329	1329.0	60.8	60.8	Cellular resistance to infection.	G B MACKANESS	J Exp Med	1962	14467923	Yes
2935	1329	1329.0	35.0	35.0	The locus coeruleus and noradrenergic modulation of cognition.	Susan J Sara	Nat Rev Neurosci	2009	19190638	No
2936	5315	1328.8	122.0	30.5	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar von Heijne, Soren Brunak	J Mol Biol	2004	15223320	Yes
2937	1328	1328.0	32.3	32.3	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2938	2656	1328.0	73.0	36.5	Mitochondria: in sickness and in health.	Jodi Nunnari, Anu Suomalainen	Cell	2012	22424226	No
2939	2655	1327.5	67.3	33.6	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2940	5308	1327.0	136.4	34.1	Measurement of the elastic properties and intrinsic strength of monolayer graphene.	Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone	Science	2008	18635798	Yes
2941	7959	1326.5	315.0	52.5	Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.	Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark Wymer	Hepatology	2016	26707365	No
2942	2652	1326.0	55.1	27.6	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2943	6627	1325.4	162.0	32.4	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2944	1325	1325.0	52.9	52.9	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2945	2650	1325.0	59.8	29.9	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2946	1325	1325.0	26.5	26.5	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
2947	2650	1325.0	68.3	34.1	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2948	2649	1324.5	108.0	54.0	Designing hydrogels for controlled drug delivery.	Jianyu Li, David J Mooney	Nat Rev Mater	2016	29657852	Yes
2949	3973	1324.3	96.3	32.1	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2950	3973	1324.3	115.7	38.6	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2951	2647	1323.5	65.0	32.5	Interneurons of the hippocampus.	T F Freund, G Buzsaki	Hippocampus	1996	8915675	No
2952	2646	1323.0	40.1	20.1	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2953	2645	1322.5	72.1	36.0	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2954	2645	1322.5	45.8	22.9	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2955	2645	1322.5	84.5	42.2	Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.	Hirenkumar K Makadia, Steven J Siegel	Polymers (Basel)	2011	22577513	Yes
2956	1322	1322.0	28.8	28.8	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2957	6607	1321.4	182.1	36.4	Quantitative assessment of tactile allodynia in the rat paw.	S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh	J Neurosci Methods	1994	7990513	Yes
2958	3964	1321.3	104.2	34.7	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Gunter Oberdorster, Eva Oberdorster, Jan Oberdorster	Environ Health Perspect	2005	16002369	No
2959	1321	1321.0	24.7	24.7	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2960	1321	1321.0	34.0	34.0	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2961	3960	1320.0	95.4	31.8	Use and abuse of HOMA modeling.	Tara M Wallace, Jonathan C Levy, David R Matthews	Diabetes Care	2004	15161807	No
2962	2640	1320.0	66.2	33.1	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2963	1320	1320.0	25.2	25.2	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
2964	6598	1319.6	247.7	49.5	Frailty in elderly people.	Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood	Lancet	2013	23395245	No
2965	2639	1319.5	306.5	153.2	The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.	Karin E de Visser, Johanna A Joyce	Cancer Cell	2023	36917948	No
2966	1319	1319.0	68.9	68.9	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2967	1319	1319.0	26.0	26.0	Searching for intellectual turning points: progressive knowledge domain visualization.	Chaomei Chen	Proc Natl Acad Sci U S A	2004	14724295	Yes
2968	2637	1318.5	82.9	41.5	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2969	1318	1318.0	61.4	61.4	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2970	1318	1318.0	31.2	31.2	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2971	1318	1318.0	29.0	29.0	Transcriptional paradigms in mammalian mitochondrial biogenesis and function.	Richard C Scarpulla	Physiol Rev	2008	18391175	No
2972	1318	1318.0	41.5	41.5	Drug transport across the blood-brain barrier.	William M Pardridge	J Cereb Blood Flow Metab	2012	22929442	No
2973	2635	1317.5	32.6	16.3	A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography.	H VANDENDOOL, P D KRATZ	J Chromatogr	1963	14062605	Yes
2974	2635	1317.5	54.4	27.2	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2975	2633	1316.5	96.8	48.4	The Posttraumatic Growth Inventory: measuring the positive legacy of trauma.	R G Tedeschi, L G Calhoun	J Trauma Stress	1996	8827649	Yes
2976	2633	1316.5	74.3	37.1	Ischemia and reperfusion--from mechanism to translation.	Holger K Eltzschig, Tobias Eckle	Nat Med	2011	22064429	No
2977	1316	1316.0	84.7	84.7	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2978	2632	1316.0	107.1	53.5	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2979	3948	1316.0	133.7	44.6	The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting.	C Kirschbaum, K M Pirke, D H Hellhammer	Neuropsychobiology	1993	8255414	Yes
2980	2632	1316.0	52.3	26.1	TM-align: a protein structure alignment algorithm based on the TM-score.	Yang Zhang, Jeffrey Skolnick	Nucleic Acids Res	2005	15849316	Yes
2981	1316	1316.0	38.2	38.2	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2982	1316	1316.0	28.9	28.9	Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.	William C Aird	Circ Res	2007	17272818	No
2983	2630	1315.0	137.0	68.5	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R GUILLARD, J H RYTHER	Can J Microbiol	1962	13902807	Yes
2984	2630	1315.0	94.6	47.3	Tumour heterogeneity and resistance to cancer therapies.	Ibiayi Dagogo-Jack, Alice T Shaw	Nat Rev Clin Oncol	2018	29115304	No
2985	3944	1314.7	97.1	32.4	Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?	Dunyaporn Trachootham, Jerome Alexandre, Peng Huang	Nat Rev Drug Discov	2009	19478820	No
2986	2629	1314.5	99.7	49.9	Systematic review of the health benefits of physical activity and fitness in school-aged children and youth.	Ian Janssen, Allana G Leblanc	Int J Behav Nutr Phys Act	2010	20459784	Yes
2987	1314	1314.0	34.5	34.5	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2988	2628	1314.0	43.8	21.9	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2989	1314	1314.0	35.4	35.4	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2990	1314	1314.0	27.5	27.5	Human papillomavirus and cervical cancer.	Eileen M Burd	Clin Microbiol Rev	2003	12525422	No
2991	3941	1313.7	106.0	35.3	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2992	2627	1313.5	77.7	38.9	Self-management education: history, definition, outcomes, and mechanisms.	Kate R Lorig, Halsted Holman	Ann Behav Med	2003	12867348	No
2993	1313	1313.0	37.2	37.2	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2994	1313	1313.0	34.5	34.5	Autistic disturbances of affective contact.	L Kanner	Acta Paedopsychiatr	1968	4880460	Yes
2995	1313	1313.0	43.8	43.8	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2996	3938	1312.7	108.9	36.3	Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation.	Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich	Med Care	2003	12719681	Yes
2997	2624	1312.0	23.9	11.9	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2998	3936	1312.0	120.8	40.3	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
2999	2624	1312.0	46.4	23.2	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
3000	1312	1312.0	30.3	30.3	Molecular genetics of colorectal cancer.	Eric R Fearon	Annu Rev Pathol	2011	21090969	No
3001	3935	1311.7	172.8	57.6	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
3002	2623	1311.5	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A EDMONDSON, P E STEINER	Cancer	1954	13160935	Yes
3003	2622	1311.0	56.7	28.4	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
3004	1311	1311.0	28.7	28.7	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
3005	2622	1311.0	51.1	25.6	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
3006	6553	1310.6	315.5	63.1	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
3007	2621	1310.5	49.8	24.9	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
3008	5239	1309.8	270.4	67.6	Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks.	Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun	IEEE Trans Pattern Anal Mach Intell	2017	27295650	Yes
3009	2618	1309.0	59.3	29.6	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
3010	1309	1309.0	43.5	43.5	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
3011	1309	1309.0	29.7	29.7	Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.	S G Johnsen	Hormones	1970	5527187	Yes
3012	1309	1309.0	30.8	30.8	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
3013	2618	1309.0	63.0	31.5	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
3014	1309	1309.0	39.6	39.6	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
3015	1309	1309.0	27.0	27.0	VEGF as a key mediator of angiogenesis in cancer.	Peter Carmeliet	Oncology	2005	16301830	No
3016	1309	1309.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F SCHOLANDER	J Biol Chem	1947	20281644	Yes
3017	1308	1308.0	39.2	39.2	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
3018	1308	1308.0	27.4	27.4	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
3019	1308	1308.0	53.7	53.7	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
3020	3923	1307.7	82.5	27.5	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
3021	2615	1307.5	59.6	29.8	ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis.	Benoit D'Autreaux, Michel B Toledano	Nat Rev Mol Cell Biol	2007	17848967	No
3022	2614	1307.0	61.2	30.6	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
3023	1307	1307.0	34.0	34.0	Production and scavenging of reactive oxygen species in chloroplasts and their functions.	Kozi Asada	Plant Physiol	2006	16760493	Yes
3024	2613	1306.5	55.2	27.6	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
3025	2613	1306.5	57.2	28.6	Establishing, maintaining and modifying DNA methylation patterns in plants and animals.	Julie A Law, Steven E Jacobsen	Nat Rev Genet	2010	20142834	No
3026	2612	1306.0	77.4	38.7	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
3027	1306	1306.0	45.7	45.7	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
3028	1306	1306.0	34.8	34.8	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
3029	1306	1306.0	22.7	22.7	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
3030	1306	1306.0	24.1	24.1	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
3031	1306	1306.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L MILLER	Science	1953	13056598	Yes
3032	1306	1306.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S FARR	J Infect Dis	1958	13611294	Yes
3033	3918	1306.0	96.6	32.2	Matrix metalloproteinases: regulators of the tumor microenvironment.	Kai Kessenbrock, Vicki Plaks, Zena Werb	Cell	2010	20371345	No
3034	2611	1305.5	79.3	39.6	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
3035	1305	1305.0	29.5	29.5	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
3036	1305	1305.0	30.8	30.8	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
3037	1305	1305.0	30.9	30.9	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
3038	1305	1305.0	26.9	26.9	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
3039	1305	1305.0	32.2	32.2	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
3040	1305	1305.0	34.8	34.8	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
3041	7829	1304.8	172.8	28.8	Staging of brain pathology related to sporadic Parkinson's disease.	Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak	Neurobiol Aging	2003	12498954	Yes
3042	2609	1304.5	62.8	31.4	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
3043	2609	1304.5	80.3	40.1	The complexity of NF-κB signaling in inflammation and cancer.	Bastian Hoesel, Johannes A Schmid	Mol Cancer	2013	23915189	No
3044	1304	1304.0	32.6	32.6	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
3045	2607	1303.5	50.1	25.1	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
3046	2606	1303.0	83.0	41.5	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
3047	1303	1303.0	28.9	28.9	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
3048	1303	1303.0	35.4	35.4	Depression in the elderly.	George S Alexopoulos	Lancet	2005	15936426	No
3049	1303	1303.0	38.7	38.7	Determining association constants from titration experiments in supramolecular chemistry.	Pall Thordarson	Chem Soc Rev	2011	21125111	Yes
3050	1303	1303.0	39.6	39.6	The inflammatory response in myocardial injury, repair, and remodelling.	Nikolaos G Frangogiannis	Nat Rev Cardiol	2014	24663091	No
3051	2605	1302.5	76.3	38.1	Multiple significance tests: the Bonferroni method.	J M Bland, D G Altman	BMJ	1995	7833759	Yes
3052	1302	1302.0	30.3	30.3	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
3053	2604	1302.0	65.6	32.8	BODIPY dyes and their derivatives: syntheses and spectroscopic properties.	Aurore Loudet, Kevin Burgess	Chem Rev	2007	17924696	Yes
3054	1302	1302.0	38.3	38.3	A practical solution to the pervasive problems of p values.	Eric-Jan Wagenmakers	Psychon Bull Rev	2007	18087943	Yes
3055	1302	1302.0	51.9	51.9	Cystic fibrosis.	J Stuart Elborn	Lancet	2016	27140670	No
3056	2603	1301.5	99.4	49.7	A simple method to assess exercise behavior in the community.	G Godin, R J Shephard	Can J Appl Sport Sci	1985	4053261	Yes
3057	1301	1301.0	46.1	46.1	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
3058	2602	1301.0	68.7	34.4	Heterogeneous photocatalyst materials for water splitting.	Akihiko Kudo, Yugo Miseki	Chem Soc Rev	2009	19088977	Yes
3059	2601	1300.5	53.1	26.6	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
3060	2601	1300.5	44.8	22.4	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
3061	1300	1300.0	33.8	33.8	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
3062	1300	1300.0	0.0	0.0	Agammaglobulinemia.	O C BRUTON	Pediatrics	1952	14929630	Yes
3063	3899	1299.7	90.8	30.3	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
3064	1299	1299.0	25.9	25.9	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
3065	2597	1298.5	82.6	41.3	Efficacy of the Theory of Planned Behaviour: a meta-analytic review.	C J Armitage, M Conner	Br J Soc Psychol	2001	11795063	Yes
3066	1298	1298.0	44.1	44.1	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
3067	1298	1298.0	25.1	25.1	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
3068	1298	1298.0	28.7	28.7	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
3069	2596	1298.0	66.6	33.3	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
3070	1298	1298.0	24.8	24.8	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
3071	1298	1298.0	55.3	55.3	Review of the psychometric evidence of the perceived stress scale.	Eun-Hyun Lee	Asian Nurs Res (Korean Soc Nurs Sci)	2012	25031113	Yes
3072	1298	1298.0	46.4	46.4	Epidemiology and risk factors for IBD.	Ashwin N Ananthakrishnan	Nat Rev Gastroenterol Hepatol	2015	25732745	No
3073	1297	1297.0	30.8	30.8	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
3074	1297	1297.0	44.1	44.1	Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery.	L Sjostrom	J Intern Med	2013	23163728	No
3075	2593	1296.5	65.7	32.9	Mechanisms of mitophagy.	Richard J Youle, Derek P Narendra	Nat Rev Mol Cell Biol	2011	21179058	No
3076	1296	1296.0	39.5	39.5	Social support and health: a review of physiological processes potentially underlying links to disease outcomes.	Bert N Uchino	J Behav Med	2006	16758315	No
3077	1296	1296.0	24.3	24.3	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
3078	2592	1296.0	70.9	35.5	Are the dorsal and ventral hippocampus functionally distinct structures?	Michael S Fanselow, Hong-Wei Dong	Neuron	2010	20152109	No
3079	2592	1296.0	54.9	27.4	The Polycomb complex PRC2 and its mark in life.	Raphael Margueron, Danny Reinberg	Nature	2011	21248841	No
3080	1295	1295.0	59.2	59.2	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
3081	2590	1295.0	163.3	81.7	The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.	Hussin A Rothan, Siddappa N Byrareddy	J Autoimmun	2020	32113704	No
3082	12946	1294.6	312.6	31.3	Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.	M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz	Cytotherapy	2006	16923606	Yes
3083	2588	1294.0	49.5	24.8	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
3084	1294	1294.0	42.0	42.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
3085	1294	1294.0	31.0	31.0	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
3086	1294	1294.0	27.2	27.2	r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock.	Michael J Sanderson	Bioinformatics	2003	12538260	Yes
3087	3881	1293.7	176.2	58.7	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3088	3881	1293.7	87.2	29.1	Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis.	Sang-Dong Yoo, Young-Hee Cho, Jen Sheen	Nat Protoc	2007	17585298	Yes
3089	1293	1293.0	42.1	42.1	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
3090	1293	1293.0	32.3	32.3	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
3091	3879	1293.0	89.0	29.7	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
3092	2585	1292.5	48.0	24.0	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
3093	1292	1292.0	14.4	14.4	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
3094	1292	1292.0	31.7	31.7	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
3095	1292	1292.0	27.4	27.4	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
3096	2584	1292.0	48.3	24.1	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
3097	2584	1292.0	51.9	25.9	Protein aggregation and neurodegenerative disease.	Christopher A Ross, Michelle A Poirier	Nat Med	2004	15272267	No
3098	1292	1292.0	32.5	32.5	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
3099	1292	1292.0	41.0	41.0	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
3100	2584	1292.0	54.5	27.2	Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.	William G Kaelin, Peter J Ratcliffe	Mol Cell	2008	18498744	No
3101	2583	1291.5	65.7	32.9	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
3102	2583	1291.5	97.8	48.9	Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.	Michael A Gimbrone, Guillermo Garcia-Cardena	Circ Res	2016	26892962	No
3103	1291	1291.0	36.2	36.2	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
3104	2582	1291.0	44.5	22.2	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
3105	2581	1290.5	65.9	33.0	Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.	I Chopra, M Roberts	Microbiol Mol Biol Rev	2001	11381101	Yes
3106	3871	1290.3	107.8	35.9	Development and applications of CRISPR-Cas9 for genome engineering.	Patrick D Hsu, Eric S Lander, Feng Zhang	Cell	2014	24906146	No
3107	1290	1290.0	73.7	73.7	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D WINTER	Nature	1962	14007593	Yes
3108	3870	1290.0	133.5	44.5	Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.	Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott	Physiol Rev	2014	24987008	No
3109	2579	1289.5	109.3	54.6	Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.	Luigi Ferrucci, Elisa Fabbri	Nat Rev Cardiol	2018	30065258	No
3110	1289	1289.0	32.0	32.0	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
3111	1289	1289.0	37.9	37.9	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3112	2576	1288.0	89.2	44.6	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
3113	5152	1288.0	106.1	26.5	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
3114	1288	1288.0	27.0	27.0	Serine protease mechanism and specificity.	Lizbeth Hedstrom	Chem Rev	2002	12475199	No
3115	1288	1288.0	34.5	34.5	Rethinking schizophrenia.	Thomas R Insel	Nature	2010	21068826	No
3116	1287	1287.0	38.8	38.8	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
3117	2574	1287.0	60.6	30.3	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
3118	1287	1287.0	39.5	39.5	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
3119	1287	1287.0	30.5	30.5	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
3120	2574	1287.0	78.9	39.5	Antiseptics and disinfectants: activity, action, and resistance.	G McDonnell, A D Russell	Clin Microbiol Rev	1999	9880479	No
3121	1287	1287.0	50.3	50.3	The anatomy of stages of change.	A Bandura	Am J Health Promot	1997	10170438	No
3122	1287	1287.0	22.9	22.9	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
3123	2574	1287.0	59.4	29.7	Toxoplasmosis.	J G Montoya, O Liesenfeld	Lancet	2004	15194258	No
3124	1286	1286.0	36.7	36.7	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Boyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
3125	1286	1286.0	39.2	39.2	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
3126	3856	1285.3	115.8	38.6	PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations.	J W Varni, M Seid, P S Kurtin	Med Care	2001	11468499	Yes
3127	1285	1285.0	32.7	32.7	A theory of magnitude: common cortical metrics of time, space and quantity.	Vincent Walsh	Trends Cogn Sci	2003	14585444	Yes
3128	1284	1284.0	49.3	49.3	A simple method for determination of serum catalase activity and revision of reference range.	L Goth	Clin Chim Acta	1991	2029780	Yes
3129	1284	1284.0	29.5	29.5	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
3130	1284	1284.0	30.8	30.8	Ovarian cancer development and metastasis.	Ernst Lengyel	Am J Pathol	2010	20651229	Yes
3131	2568	1284.0	131.4	65.7	Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas.	Amy J H Kind, William R Buckingham	N Engl J Med	2018	29949490	Yes
3132	2567	1283.5	13.5	6.8	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J TODARO, H GREEN	J Cell Biol	1963	13985244	Yes
3133	2566	1283.0	57.5	28.8	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
3134	1283	1283.0	25.2	25.2	Understanding the odd science of aging.	Thomas B L Kirkwood	Cell	2005	15734677	No
3135	11547	1283.0	278.7	31.0	Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.	Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter	Nat Biotechnol	2010	20436464	Yes
3136	2565	1282.5	48.7	24.4	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
3137	1282	1282.0	46.3	46.3	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
3138	1282	1282.0	25.4	25.4	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
3139	2564	1282.0	59.0	29.5	Endometriosis.	Linda C Giudice, Lee C Kao	Lancet	2004	15541453	No
3140	2563	1281.5	50.8	25.4	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
3141	1281	1281.0	34.3	34.3	Transcranial magnetic stimulation: a primer.	Mark Hallett	Neuron	2007	17640522	No
3142	1281	1281.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B VERNEY	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
3143	1281	1281.0	30.3	30.3	Identifying and characterizing binding sites and assessing druggability.	Thomas A Halgren	J Chem Inf Model	2009	19434839	Yes
3144	2560	1280.0	78.5	39.2	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
3145	1280	1280.0	27.7	27.7	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
3146	1280	1280.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M KALCKAR	J Biol Chem	1947	20285041	Yes
3147	2560	1280.0	78.3	39.1	Prostaglandins and inflammation.	Emanuela Ricciotti, Garret A FitzGerald	Arterioscler Thromb Vasc Biol	2011	21508345	No
3148	3839	1279.7	148.2	49.4	Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.	Antonio Ayala, Mario F Munoz, Sandro Arguelles	Oxid Med Cell Longev	2014	24999379	No
3149	2559	1279.5	66.3	33.1	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundstrom, K Nilsson	Int J Cancer	1976	178611	Yes
3150	1279	1279.0	31.7	31.7	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
3151	1279	1279.0	30.6	30.6	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
3152	2557	1278.5	102.0	51.0	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Naatanen, T Picton	Psychophysiology	1987	3615753	Yes
3153	2556	1278.0	85.0	42.5	A simple index of Crohn's-disease activity.	R F Harvey, J M Bradshaw	Lancet	1980	6102236	Yes
3154	1278	1278.0	37.9	37.9	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
3155	8941	1277.3	223.2	31.9	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	, Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
3156	5108	1277.0	144.0	36.0	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
3157	1277	1277.0	26.2	26.2	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
3158	3829	1276.3	91.6	30.5	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
3159	3828	1276.0	113.1	37.7	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
3160	1276	1276.0	33.0	33.0	Philosophical conceptions of the self: implications for cognitive science.	Shaun Gallagher	Trends Cogn Sci	2000	10637618	Yes
3161	1276	1276.0	32.3	32.3	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
3162	2551	1275.5	52.0	26.0	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
3163	1275	1275.0	36.3	36.3	Pectin structure and biosynthesis.	Debra Mohnen	Curr Opin Plant Biol	2008	18486536	No
3164	2550	1275.0	78.9	39.5	Infernal 1.1: 100-fold faster RNA homology searches.	Eric P Nawrocki, Sean R Eddy	Bioinformatics	2013	24008419	Yes
3165	2549	1274.5	52.6	26.3	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
3166	2549	1274.5	50.8	25.4	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
3167	2549	1274.5	48.7	24.4	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
3168	2549	1274.5	50.2	25.1	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	Nahum Sonenberg, Alan G Hinnebusch	Cell	2009	19239892	No
3169	1274	1274.0	61.3	61.3	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
3170	1274	1274.0	69.7	69.7	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A ROSE	Bull World Health Organ	1962	13974778	Yes
3171	1274	1274.0	32.1	32.1	AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.	D Grahame Hardie	Genes Dev	2011	21937710	No
3172	2547	1273.5	80.9	40.5	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
3173	2547	1273.5	91.0	45.5	Comparative Protein Structure Modeling Using MODELLER.	Benjamin Webb, Andrej Sali	Curr Protoc Bioinformatics	2016	27322406	Yes
3174	1273	1273.0	22.0	22.0	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
3175	1273	1273.0	26.5	26.5	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
3176	1273	1273.0	46.8	46.8	Intention-to-treat concept: A review.	Sandeep K Gupta	Perspect Clin Res	2011	21897887	Yes
3177	2545	1272.5	66.6	33.3	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
3178	2544	1272.0	98.0	49.0	Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine.	G Atkinson, A M Nevill	Sports Med	1998	9820922	No
3179	1272	1272.0	27.7	27.7	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
3180	2544	1272.0	68.9	34.5	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
3181	3816	1272.0	98.8	32.9	FastTree: computing large minimum evolution trees with profiles instead of a distance matrix.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	Mol Biol Evol	2009	19377059	Yes
3182	3814	1271.3	127.0	42.3	Ecological momentary assessment.	Saul Shiffman, Arthur A Stone, Michael R Hufford	Annu Rev Clin Psychol	2008	18509902	No
3183	1271	1271.0	40.4	40.4	Agents that increase the permeability of the outer membrane.	M Vaara	Microbiol Rev	1992	1406489	No
3184	1271	1271.0	30.1	30.1	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
3185	1271	1271.0	36.1	36.1	pegas: an R package for population genetics with an integrated-modular approach.	Emmanuel Paradis	Bioinformatics	2010	20080509	Yes
3186	2541	1270.5	61.7	30.9	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
3187	2541	1270.5	65.6	32.8	Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.	Patrick S Ward, Craig B Thompson	Cancer Cell	2012	22439925	No
3188	1270	1270.0	22.3	22.3	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
3189	2539	1269.5	103.3	51.6	Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.	Douglas J Morrison, Tom Preston	Gut Microbes	2016	26963409	No
3190	10148	1268.5	309.4	38.7	Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.	V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks	Am J Prev Med	1998	9635069	Yes
3191	13954	1268.5	324.1	29.5	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
3192	2536	1268.0	57.0	28.5	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
3193	1268	1268.0	36.9	36.9	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
3194	1268	1268.0	33.6	33.6	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
3195	1268	1268.0	21.6	21.6	Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.	J O Holloszy	J Biol Chem	1967	4290225	Yes
3196	1268	1268.0	25.8	25.8	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
3197	1268	1268.0	29.6	29.6	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
3198	1268	1268.0	20.6	20.6	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
3199	1268	1268.0	32.2	32.2	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
3200	1268	1268.0	33.8	33.8	Serine, glycine and one-carbon units: cancer metabolism in full circle.	Jason W Locasale	Nat Rev Cancer	2013	23822983	No
3201	3803	1267.7	88.4	29.5	Mechanisms linking obesity to insulin resistance and type 2 diabetes.	Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider	Nature	2006	17167471	No
3202	5070	1267.5	116.6	29.1	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
3203	1267	1267.0	34.6	34.6	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
3204	1267	1267.0	46.3	46.3	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
3205	1267	1267.0	24.0	24.0	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
3206	1267	1267.0	27.6	27.6	Viruses in the sea.	Curtis A Suttle	Nature	2005	16163346	No
3207	1267	1267.0	34.4	34.4	Phosphoinositides: tiny lipids with giant impact on cell regulation.	Tamas Balla	Physiol Rev	2013	23899561	No
3208	1266	1266.0	35.9	35.9	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
3209	1266	1266.0	22.6	22.6	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
3210	2532	1266.0	57.2	28.6	ZINC--a free database of commercially available compounds for virtual screening.	John J Irwin, Brian K Shoichet	J Chem Inf Model	2005	15667143	Yes
3211	2531	1265.5	72.8	36.4	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
3212	2530	1265.0	66.7	33.4	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
3213	1265	1265.0	25.4	25.4	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
3214	1265	1265.0	130.8	130.8	Sample size determination and power analysis using the G*Power software.	Hyun Kang	J Educ Eval Health Prof	2021	34325496	No
3215	2529	1264.5	68.9	34.5	Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data.	Alexandre Tkatchenko, Matthias Scheffler	Phys Rev Lett	2009	19257665	Yes
3216	1264	1264.0	34.4	34.4	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
3217	2528	1264.0	57.8	28.9	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
3218	1264	1264.0	24.9	24.9	The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences.	P Stothard	Biotechniques	2000	10868275	Yes
3219	2527	1263.5	64.9	32.5	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
3220	1263	1263.0	46.7	46.7	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
3221	1263	1263.0	29.5	29.5	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
3222	2524	1262.0	76.6	38.3	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
3223	1262	1262.0	60.6	60.6	Self-discrepancy: a theory relating self and affect.	E T Higgins	Psychol Rev	1987	3615707	Yes
3224	1262	1262.0	28.6	28.6	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
3225	1262	1262.0	29.4	29.4	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
3226	1262	1262.0	54.3	54.3	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3227	1262	1262.0	39.0	39.0	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
3228	1262	1262.0	33.2	33.2	Neurophysiological and computational principles of cortical rhythms in cognition.	Xiao-Jing Wang	Physiol Rev	2010	20664082	No
3229	2524	1262.0	69.6	34.8	Regulation of type I interferon responses.	Lionel B Ivashkiv, Laura T Donlin	Nat Rev Immunol	2014	24362405	No
3230	1261	1261.0	24.6	24.6	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
3231	7566	1261.0	162.2	27.0	Principal components analysis corrects for stratification in genome-wide association studies.	Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich	Nat Genet	2006	16862161	Yes
3232	1261	1261.0	28.9	28.9	ImageJ for microscopy.	Tony J Collins	Biotechniques	2007	17936939	No
3233	1260	1260.0	25.7	25.7	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
3234	1260	1260.0	36.0	36.0	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
3235	1260	1260.0	54.8	54.8	A decade of immune-checkpoint inhibitors in cancer therapy.	Caroline Robert	Nat Commun	2020	32732879	Yes
3236	13854	1259.5	254.8	23.2	Model-based analysis of ChIP-Seq (MACS).	Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu	Genome Biol	2008	18798982	Yes
3237	1259	1259.0	25.0	25.0	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
3238	1259	1259.0	26.4	26.4	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
3239	1259	1259.0	34.7	34.7	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
3240	1259	1259.0	30.9	30.9	An introduction to data reduction: space-group determination, scaling and intensity statistics.	Philip R Evans	Acta Crystallogr D Biol Crystallogr	2011	21460446	Yes
3241	7550	1258.3	276.9	46.1	GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.	Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang	Nucleic Acids Res	2017	28407145	Yes
3242	1258	1258.0	35.5	35.5	A human model of gastric carcinogenesis.	P Correa	Cancer Res	1988	3288329	No
3243	2516	1258.0	61.0	30.5	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
3244	1258	1258.0	26.5	26.5	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
3245	1258	1258.0	25.5	25.5	Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.	Michael Forgac	Nat Rev Mol Cell Biol	2007	17912264	No
3246	2515	1257.5	67.3	33.6	Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.	Marie Cargnello, Philippe P Roux	Microbiol Mol Biol Rev	2011	21372320	No
3247	2515	1257.5	92.2	46.1	Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.	Jerome Galon, Daniela Bruni	Nat Rev Drug Discov	2019	30610226	No
3248	6286	1257.2	168.0	33.6	Biodiversity hotspots for conservation priorities.	N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J Kent	Nature	2000	10706275	Yes
3249	1257	1257.0	44.5	44.5	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
3250	1257	1257.0	22.7	22.7	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
3251	5028	1257.0	130.4	32.6	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Madler, Ning Li	Science	2006	16456071	No
3252	1257	1257.0	42.8	42.8	Considerations in determining sample size for pilot studies.	Melody A Hertzog	Res Nurs Health	2008	18183564	No
3253	2513	1256.5	68.6	34.3	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
3254	1256	1256.0	46.7	46.7	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
3255	2512	1256.0	91.3	45.6	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
3256	1256	1256.0	25.6	25.6	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
3257	1256	1256.0	31.4	31.4	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
3258	1256	1256.0	0.0	0.0	A modification of receptor theory.	R P STEPHENSON	Br J Pharmacol Chemother	1956	13383117	Yes
3259	1256	1256.0	41.9	41.9	Human milk oligosaccharides: every baby needs a sugar mama.	Lars Bode	Glycobiology	2012	22513036	No
3260	1255	1255.0	30.7	30.7	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
3261	1255	1255.0	42.0	42.0	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
3262	1255	1255.0	31.6	31.6	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
3263	2510	1255.0	58.2	29.1	Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations.	In Suk Joung, Thomas E Cheatham	J Phys Chem B	2008	18593145	Yes
3264	1255	1255.0	56.5	56.5	The expanding regulatory mechanisms and cellular functions of circular RNAs.	Ling-Ling Chen	Nat Rev Mol Cell Biol	2020	32366901	No
3265	2509	1254.5	69.5	34.8	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
3266	1254	1254.0	25.1	25.1	Evolution of ageing.	T B Kirkwood	Nature	1977	593350	Yes
3267	1254	1254.0	22.8	22.8	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
3268	1254	1254.0	26.8	26.8	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
3269	1254	1254.0	35.2	35.2	The role of rumination in depressive disorders and mixed anxiety/depressive symptoms.	S Nolen-Hoeksema	J Abnorm Psychol	2000	11016119	Yes
3270	1254	1254.0	33.0	33.0	What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models.	Michael A Babyak	Psychosom Med	2004	15184705	Yes
3271	1254	1254.0	30.7	30.7	Bile acids: regulation of synthesis.	John Y L Chiang	J Lipid Res	2009	19346330	No
3272	2507	1253.5	57.5	28.8	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
3273	3760	1253.3	90.4	30.1	The widespread regulation of microRNA biogenesis, function and decay.	Jacek Krol, Inga Loedige, Witold Filipowicz	Nat Rev Genet	2010	20661255	No
3274	1253	1253.0	62.6	62.6	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
3275	1253	1253.0	45.2	45.2	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
3276	1253	1253.0	32.4	32.4	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
3277	1253	1253.0	30.4	30.4	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
3278	1253	1253.0	0.0	0.0	Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.	P B MEDAWAR	Br J Exp Pathol	1948	18865105	Yes
3279	3759	1253.0	105.0	35.0	SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building.	Manolo Gouy, Stephane Guindon, Olivier Gascuel	Mol Biol Evol	2010	19854763	Yes
3280	3758	1252.7	76.3	25.4	5-fluorouracil: mechanisms of action and clinical strategies.	Daniel B Longley, D Paul Harkin, Patrick G Johnston	Nat Rev Cancer	2003	12724731	No
3281	2505	1252.5	73.0	36.5	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3282	1251	1251.0	22.5	22.5	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
3283	7505	1250.8	165.1	27.5	Enzymatic assembly of DNA molecules up to several hundred kilobases.	Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith	Nat Methods	2009	19363495	Yes
3284	8755	1250.7	265.6	37.9	Toxicity and response criteria of the Eastern Cooperative Oncology Group.	M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone	Am J Clin Oncol	1982	7165009	Yes
3285	2500	1250.0	118.8	59.4	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
3286	2500	1250.0	48.4	24.2	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
3287	1250	1250.0	15.7	15.7	The concept of immunological surveillance.	F M Burnet	Prog Exp Tumor Res	1970	4921480	No
3288	1250	1250.0	43.4	43.4	Type 2 inflammation in asthma--present in most, absent in many.	John V Fahy	Nat Rev Immunol	2015	25534623	No
3289	2499	1249.5	66.0	33.0	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
3290	2499	1249.5	48.2	24.1	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
3291	1249	1249.0	26.6	26.6	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
3292	1249	1249.0	25.9	25.9	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
3293	2498	1249.0	52.2	26.1	Deep tissue two-photon microscopy.	Fritjof Helmchen, Winfried Denk	Nat Methods	2005	16299478	No
3294	1248	1248.0	24.6	24.6	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
3295	1248	1248.0	30.1	30.1	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
3296	1248	1248.0	33.1	33.1	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
3297	2495	1247.5	62.7	31.4	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
3298	2495	1247.5	64.1	32.0	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
3299	1247	1247.0	60.5	60.5	Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.	Hector F Escobar-Morreale	Nat Rev Endocrinol	2018	29569621	No
3300	1246	1246.0	27.3	27.3	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
3301	1246	1246.0	0.0	0.0	Sequential tests for the detection of linkage.	N E MORTON	Am J Hum Genet	1955	13258560	Yes
3302	1246	1246.0	47.7	47.7	Bisphenol A and human health: a review of the literature.	Johanna R Rochester	Reprod Toxicol	2013	23994667	No
3303	2490	1245.0	91.5	45.8	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
3304	1245	1245.0	23.4	23.4	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
3305	3735	1245.0	95.6	31.9	Regulation of cancer cell metabolism.	Rob A Cairns, Isaac S Harris, Tak W Mak	Nat Rev Cancer	2011	21258394	No
3306	1245	1245.0	39.1	39.1	Globalization of diabetes: the role of diet, lifestyle, and genes.	Frank B Hu	Diabetes Care	2011	21617109	No
3307	6222	1244.4	113.2	22.6	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
3308	8710	1244.3	563.4	80.5	TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data.	Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia	Mol Plant	2020	32585190	Yes
3309	1244	1244.0	37.1	37.1	MOPAC: a semiempirical molecular orbital program.	J J Stewart	J Comput Aided Mol Des	1990	2197373	No
3310	1244	1244.0	29.3	29.3	Formation and function of the myofibroblast during tissue repair.	Boris Hinz	J Invest Dermatol	2007	17299435	No
3311	2487	1243.5	82.5	41.2	Consensus methods for medical and health services research.	J Jones, D Hunter	BMJ	1995	7640549	No
3312	1243	1243.0	37.0	37.0	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
3313	1242	1242.0	58.7	58.7	Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase.	Y Kono	Arch Biochem Biophys	1978	24422	Yes
3314	2484	1242.0	67.8	33.9	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
3315	1242	1242.0	59.3	59.3	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
3316	1242	1242.0	41.8	41.8	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
3317	2484	1242.0	60.9	30.4	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
3318	1242	1242.0	38.6	38.6	Dual-processing accounts of reasoning, judgment, and social cognition.	Jonathan St B T Evans	Annu Rev Psychol	2008	18154502	No
3319	1242	1242.0	33.9	33.9	ERK1/2 MAP kinases: structure, function, and regulation.	Robert Roskoski	Pharmacol Res	2012	22569528	No
3320	2483	1241.5	84.0	42.0	A formula to estimate the approximate surface area if height and weight be known. 1916.	D Du Bois, E F Du Bois	Nutrition	1989	2520314	No
3321	3724	1241.3	93.3	31.1	Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation.	Davis J McCarthy, Yunshun Chen, Gordon K Smyth	Nucleic Acids Res	2012	22287627	Yes
3322	1241	1241.0	36.1	36.1	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
3323	2482	1241.0	55.3	27.6	The host defense of Drosophila melanogaster.	Bruno Lemaitre, Jules Hoffmann	Annu Rev Immunol	2007	17201680	No
3324	1241	1241.0	41.1	41.1	DREADDs for Neuroscientists.	Bryan L Roth	Neuron	2016	26889809	No
3325	12405	1240.5	396.5	39.6	The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.	N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de Haes	J Natl Cancer Inst	1993	8433390	Yes
3326	1240	1240.0	55.3	55.3	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
3327	1240	1240.0	77.3	77.3	Root canal anatomy of the human permanent teeth.	F J Vertucci	Oral Surg Oral Med Oral Pathol	1984	6595621	Yes
3328	1240	1240.0	15.4	15.4	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M VAN ROSSUM	Arch Int Pharmacodyn Ther	1963	13996119	Yes
3329	1240	1240.0	21.3	21.3	NFAT proteins: key regulators of T-cell development and function.	Fernando Macian	Nat Rev Immunol	2005	15928679	No
3330	1239	1239.0	20.3	20.3	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
3331	2478	1239.0	53.2	26.6	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N AMES, D T DUBIN	J Biol Chem	1960	13793161	Yes
3332	3716	1238.7	71.4	23.8	SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.	Jay D Horton, Joseph L Goldstein, Michael S Brown	J Clin Invest	2002	11994399	No
3333	6193	1238.6	191.0	38.2	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
3334	7429	1238.2	135.3	22.6	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
3335	1238	1238.0	36.5	36.5	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
3336	1238	1238.0	37.6	37.6	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
3337	1238	1238.0	36.4	36.4	The mental health continuum: from languishing to flourishing in life.	Corey L M Keyes	J Health Soc Behav	2002	12096700	Yes
3338	1238	1238.0	29.1	29.1	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3339	2476	1238.0	70.2	35.1	The memory function of sleep.	Susanne Diekelmann, Jan Born	Nat Rev Neurosci	2010	20046194	No
3340	1238	1238.0	35.3	35.3	The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour.	John Duncan	Trends Cogn Sci	2010	20171926	No
3341	6187	1237.4	205.1	41.0	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
3342	3712	1237.3	180.5	60.2	Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.	Yan Zheng, Sylvia H Ley, Frank B Hu	Nat Rev Endocrinol	2018	29219149	No
3343	1237	1237.0	44.2	44.2	Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool.	Georgia Salanti	Res Synth Methods	2012	26062083	Yes
3344	2474	1237.0	184.8	92.4	Mental Health and the Covid-19 Pandemic.	Betty Pfefferbaum, Carol S North	N Engl J Med	2020	32283003	Yes
3345	2473	1236.5	89.8	44.9	Societal and individual determinants of medical care utilization in the United States.	R Andersen, J F Newman	Milbank Mem Fund Q Health Soc	1973	4198894	Yes
3346	2472	1236.0	39.3	19.6	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
3347	1236	1236.0	31.4	31.4	The quantum internet.	H J Kimble	Nature	2008	18563153	Yes
3348	1235	1235.0	39.5	39.5	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
3349	1234	1234.0	30.6	30.6	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsaki	Neuroscience	1989	2687720	No
3350	2468	1234.0	50.0	25.0	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
3351	1234	1234.0	31.6	31.6	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
3352	2468	1234.0	58.3	29.1	The regulation of IL-10 production by immune cells.	Margarida Saraiva, Anne O'Garra	Nat Rev Immunol	2010	20154735	No
3353	1233	1233.0	21.1	21.1	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
3354	1233	1233.0	23.0	23.0	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
3355	1233	1233.0	23.8	23.8	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
3356	2465	1232.5	63.3	31.6	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
3357	2465	1232.5	77.4	38.7	Toll-like receptor signaling pathways.	Takumi Kawasaki, Taro Kawai	Front Immunol	2014	25309543	No
3358	1232	1232.0	29.3	29.3	Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly"	F D Haldane	Phys Rev Lett	1988	10038961	Yes
3359	3696	1232.0	82.6	27.5	Marginal structural models and causal inference in epidemiology.	J M Robins, M A Hernan, B Brumback	Epidemiology	2000	10955408	Yes
3360	1232	1232.0	30.0	30.0	Optogenetics.	Karl Deisseroth	Nat Methods	2011	21191368	Yes
3361	2463	1231.5	64.6	32.3	Mechanisms of biofilm resistance to antimicrobial agents.	T F Mah, G A O'Toole	Trends Microbiol	2001	11166241	No
3362	1231	1231.0	26.8	26.8	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
3363	1231	1231.0	27.3	27.3	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
3364	1231	1231.0	31.3	31.3	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
3365	2462	1231.0	57.9	28.9	Sulforhodamine B colorimetric assay for cytotoxicity screening.	Vanicha Vichai, Kanyawim Kirtikara	Nat Protoc	2006	17406391	Yes
3366	3690	1230.0	103.3	34.4	A sensitive and reliable locomotor rating scale for open field testing in rats.	D M Basso, M S Beattie, J C Bresnahan	J Neurotrauma	1995	7783230	Yes
3367	1230	1230.0	24.2	24.2	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
3368	1230	1230.0	33.6	33.6	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
3369	1230	1230.0	32.9	32.9	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
3370	2460	1230.0	68.9	34.5	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
3371	1230	1230.0	29.8	29.8	Overview of the immune response.	David D Chaplin	J Allergy Clin Immunol	2010	20176265	No
3372	1229	1229.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G BUONOCORE	J Dent Res	1955	13271655	Yes
3373	2458	1229.0	51.9	25.9	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
3374	2458	1229.0	48.7	24.4	The mammalian unfolded protein response.	Martin Schroder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
3375	1229	1229.0	45.5	45.5	The angular gyrus: multiple functions and multiple subdivisions.	Mohamed L Seghier	Neuroscientist	2013	22547530	No
3376	2458	1229.0	92.1	46.0	The Human Intestinal Microbiome in Health and Disease.	Susan V Lynch, Oluf Pedersen	N Engl J Med	2016	27974040	No
3377	2457	1228.5	72.8	36.4	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
3378	1228	1228.0	33.8	33.8	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
3379	1228	1228.0	25.2	25.2	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
3380	2456	1228.0	51.7	25.9	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
3381	1228	1228.0	33.9	33.9	Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies.	Masabumi Shibuya	Genes Cancer	2011	22866201	Yes
3382	2455	1227.5	125.3	62.6	The Neck Disability Index: a study of reliability and validity.	H Vernon, S Mior	J Manipulative Physiol Ther	1991	1834753	Yes
3383	2454	1227.0	53.6	26.8	Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.	G K McMaster, G G Carmichael	Proc Natl Acad Sci U S A	1977	73185	Yes
3384	1227	1227.0	109.3	109.3	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
3385	1227	1227.0	25.2	25.2	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
3386	3681	1227.0	127.4	42.5	Neighborhoods and violent crime: a multilevel study of collective efficacy.	R J Sampson, S W Raudenbush, F Earls	Science	1997	9252316	Yes
3387	1227	1227.0	23.7	23.7	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
3388	3681	1227.0	138.5	46.2	The biology and management of non-small cell lung cancer.	Roy S Herbst, Daniel Morgensztern, Chris Boshoff	Nature	2018	29364287	No
3389	2453	1226.5	88.5	44.2	Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes.	I B Wilson, P D Cleary	JAMA	1995	7996652	Yes
3390	1226	1226.0	58.3	58.3	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
3391	1226	1226.0	27.2	27.2	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
3392	1226	1226.0	24.6	24.6	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
3393	1226	1226.0	0.0	0.0	Voluntary strength and fatigue.	P A MERTON	J Physiol	1954	13152698	Yes
3394	2450	1225.0	54.2	27.1	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
3395	1225	1225.0	32.0	32.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
3396	1225	1225.0	22.1	22.1	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
3397	1225	1225.0	25.9	25.9	Lithium batteries and cathode materials.	M Stanley Whittingham	Chem Rev	2004	15669156	Yes
3398	1225	1225.0	40.5	40.5	What Good Are Positive Emotions?	Barbara L Fredrickson	Rev Gen Psychol	1998	21850154	Yes
3399	4898	1224.5	140.0	35.0	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
3400	1224	1224.0	63.8	63.8	The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement.	M M Panjabi	J Spinal Disord	1992	1490034	Yes
3401	1224	1224.0	28.4	28.4	Growth factors and cancer.	S A Aaronson	Science	1991	1659742	No
3402	1224	1224.0	28.1	28.1	Intracellular protein topogenesis.	G Blobel	Proc Natl Acad Sci U S A	1980	6929499	Yes
3403	2448	1224.0	57.4	28.7	Interaction revisited: the difference between two estimates.	Douglas G Altman, J Martin Bland	BMJ	2003	12543843	No
3404	2448	1224.0	352.2	176.1	Sample sizes for saturation in qualitative research: A systematic review of empirical tests.	Monique Hennink, Bonnie N Kaiser	Soc Sci Med	2022	34785096	Yes
3405	2447	1223.5	71.8	35.9	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
3406	1223	1223.0	28.5	28.5	The epidemiologic transition. A theory of the epidemiology of population change.	A R Omran	Milbank Mem Fund Q	1971	5155251	Yes
3407	3668	1222.7	121.6	40.5	Social relationships and mortality risk: a meta-analytic review.	Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton	PLoS Med	2010	20668659	No
3408	2444	1222.0	82.6	41.3	The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.	G P Chrousos, P W Gold	JAMA	1992	1538563	No
3409	2444	1222.0	97.4	48.7	The Tumor Microenvironment Innately Modulates Cancer Progression.	Dominique C Hinshaw, Lalita A Shevde	Cancer Res	2019	31350295	No
3410	3665	1221.7	101.7	33.9	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
3411	1221	1221.0	25.7	25.7	Antigen-presenting function of the macrophage.	E R Unanue	Annu Rev Immunol	1984	6242349	No
3412	1221	1221.0	59.5	59.5	Osseointegration and its experimental background.	P I Branemark	J Prosthet Dent	1983	6352924	No
3413	1221	1221.0	74.1	74.1	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
3414	1221	1221.0	26.1	26.1	Dendritic cells: unique leukocyte populations which control the primary immune response.	D N Hart	Blood	1997	9345009	No
3415	1221	1221.0	31.1	31.1	Abiotic stress, the field environment and stress combination.	Ron Mittler	Trends Plant Sci	2006	16359910	No
3416	2442	1221.0	87.9	44.0	Gut microbiota, metabolites and host immunity.	Michelle G Rooks, Wendy S Garrett	Nat Rev Immunol	2016	27231050	No
3417	3662	1220.7	182.6	60.9	Relatives of the impaired elderly: correlates of feelings of burden.	S H Zarit, K E Reever, J Bach-Peterson	Gerontologist	1980	7203086	Yes
3418	1220	1220.0	40.5	40.5	The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.	N M Kaplan	Arch Intern Med	1989	2662932	No
3419	1220	1220.0	30.4	30.4	Endothelial-leukocyte adhesion molecules.	M P Bevilacqua	Annu Rev Immunol	1993	8476577	No
3420	1220	1220.0	29.1	29.1	Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill.	R Zahorec	Bratisl Lek Listy	2001	11723675	Yes
3421	2440	1220.0	52.3	26.1	microRNA functions.	Natascha Bushati, Stephen M Cohen	Annu Rev Cell Dev Biol	2007	17506695	No
3422	2438	1219.0	62.2	31.1	Fitness effects on the cognitive function of older adults: a meta-analytic study.	Stanley Colcombe, Arthur F Kramer	Psychol Sci	2003	12661673	Yes
3423	1218	1218.0	33.1	33.1	What is synergy?	M C Berenbaum	Pharmacol Rev	1989	2692037	No
3424	1218	1218.0	63.5	63.5	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
3425	1218	1218.0	27.0	27.0	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
3426	3654	1218.0	72.3	24.1	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
3427	2436	1218.0	26.2	13.1	The Aggregation Of Blood Platelets.	G V BORN, M J CROSS	J Physiol	1963	14056485	Yes
3428	3654	1218.0	110.3	36.8	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
3429	2435	1217.5	61.1	30.6	Localized surface plasmon resonance spectroscopy and sensing.	Katherine A Willets, Richard P Van Duyne	Annu Rev Phys Chem	2007	17067281	No
3430	3652	1217.3	60.0	20.0	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, Rene Bernards, Reuven Agami	Science	2002	11910072	Yes
3431	3652	1217.3	80.6	26.9	Obesity induces a phenotypic switch in adipose tissue macrophage polarization.	Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel	J Clin Invest	2007	17200717	Yes
3432	1217	1217.0	29.1	29.1	Bcl-2 initiates a new category of oncogenes: regulators of cell death.	S J Korsmeyer	Blood	1992	1498330	No
3433	1217	1217.0	42.4	42.4	Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators.	B A Hess	Phys Rev A Gen Phys	1986	9897114	Yes
3434	2434	1217.0	50.8	25.4	Finding and evaluating community structure in networks.	M E J Newman, M Girvan	Phys Rev E Stat Nonlin Soft Matter Phys	2004	14995526	Yes
3435	1217	1217.0	31.7	31.7	Cholinesterase inhibitors for Alzheimer's disease.	J Birks	Cochrane Database Syst Rev	2006	16437532	Yes
3436	2434	1217.0	68.3	34.1	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
3437	1217	1217.0	25.4	25.4	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
3438	6084	1216.8	212.4	42.5	Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.	Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen	Neuroimage	2012	22019881	Yes
3439	2432	1216.0	46.1	23.1	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
3440	2432	1216.0	79.0	39.5	The gut microbiota--masters of host development and physiology.	Felix Sommer, Fredrik Backhed	Nat Rev Microbiol	2013	23435359	No
3441	3647	1215.7	92.4	30.8	Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.	Robert G Hart, Lesly A Pearce, Maria I Aguilar	Ann Intern Med	2007	17577005	Yes
3442	1215	1215.0	32.8	32.8	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
3443	1215	1215.0	33.2	33.2	On the utility of P3 amplitude as a measure of processing capacity.	A Kok	Psychophysiology	2001	11352145	No
3444	1215	1215.0	23.0	23.0	Models, mechanisms and clinical evidence for cancer dormancy.	Julio A Aguirre-Ghiso	Nat Rev Cancer	2007	17957189	No
3445	1215	1215.0	27.8	27.8	Matrix eQTL: ultra fast eQTL analysis via large matrix operations.	Andrey A Shabalin	Bioinformatics	2012	22492648	Yes
3446	2429	1214.5	95.0	47.5	Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity.	T J Cole, T Lobstein	Pediatr Obes	2012	22715120	Yes
3447	1214	1214.0	35.8	35.8	The mysteries of lipoprotein(a).	G Utermann	Science	1989	2530631	No
3448	1214	1214.0	38.1	38.1	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
3449	1214	1214.0	48.4	48.4	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
3450	1214	1214.0	30.3	30.3	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
3451	1214	1214.0	29.0	29.0	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
3452	1214	1214.0	29.8	29.8	Seed Germination and Dormancy.	J. D. Bewley	Plant Cell	1997	12237375	Yes
3453	3641	1213.7	119.7	39.9	Stimuli-responsive nanocarriers for drug delivery.	Simona Mura, Julien Nicolas, Patrick Couvreur	Nat Mater	2013	24150417	No
3454	2427	1213.5	44.5	22.2	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
3455	4853	1213.2	213.8	53.5	An ecological perspective on health promotion programs.	K R McLeroy, D Bibeau, A Steckler, K Glanz	Health Educ Q	1988	3068205	No
3456	1213	1213.0	31.4	31.4	Principles of c-di-GMP signalling in bacteria.	Regine Hengge	Nat Rev Microbiol	2009	19287449	No
3457	1213	1213.0	46.5	46.5	Vitamin D metabolism, mechanism of action, and clinical applications.	Daniel D Bikle	Chem Biol	2014	24529992	No
3458	3638	1212.7	76.4	25.5	Population structure and eigenanalysis.	Nick Patterson, Alkes L Price, David Reich	PLoS Genet	2006	17194218	Yes
3459	2425	1212.5	98.0	49.0	Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.	L A Clark, D Watson	J Abnorm Psychol	1991	1918611	No
3460	2425	1212.5	34.9	17.4	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
3461	2425	1212.5	64.3	32.1	Leukocyte-endothelial adhesion molecules.	T M Carlos, J M Harlan	Blood	1994	7522621	No
3462	1212	1212.0	33.4	33.4	Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type.	J C Morris	Int Psychogeriatr	1997	9447441	Yes
3463	2424	1212.0	53.0	26.5	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	Yes
3464	1212	1212.0	17.5	17.5	The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis.	R E HOPE-SIMPSON	Proc R Soc Med	1965	14267505	Yes
3465	1212	1212.0	33.6	33.6	Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.	Rakesh K Jain	Cancer Cell	2014	25517747	No
3466	2424	1212.0	82.5	41.2	ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap.	Tauno Metsalu, Jaak Vilo	Nucleic Acids Res	2015	25969447	Yes
3467	2424	1212.0	79.2	39.6	Long Noncoding RNAs in Cancer Pathways.	Adam M Schmitt, Howard Y Chang	Cancer Cell	2016	27070700	No
3468	2423	1211.5	104.9	52.5	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
3469	1211	1211.0	52.3	52.3	Campylobacter enteritis: a "new" disease.	M B Skirrow	Br Med J	1977	871765	Yes
3470	3633	1211.0	167.5	55.8	Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG)	P L Hudak, P C Amadio, C Bombardier	Am J Ind Med	1996	8773720	Yes
3471	1211	1211.0	20.6	20.6	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
3472	1211	1211.0	0.0	0.0	Fertilizing capacity of spermatozoa deposited into the fallopian tubes.	M C CHANG	Nature	1951	14882325	Yes
3473	1211	1211.0	30.9	30.9	Neural stimulation and recording electrodes.	Stuart F Cogan	Annu Rev Biomed Eng	2008	18429704	No
3474	1211	1211.0	31.0	31.0	Inflammation 2010: new adventures of an old flame.	Ruslan Medzhitov	Cell	2010	20303867	No
3475	1211	1211.0	33.9	33.9	Periodontitis: a polymicrobial disruption of host homeostasis.	Richard P Darveau	Nat Rev Microbiol	2010	20514045	No
3476	7265	1210.8	172.0	28.7	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins,	Lancet	2002	12493255	Yes
3477	2421	1210.5	68.7	34.4	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
3478	2421	1210.5	48.8	24.4	The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000.	A Bairoch, R Apweiler	Nucleic Acids Res	2000	10592178	Yes
3479	2421	1210.5	52.1	26.1	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
3480	1210	1210.0	26.6	26.6	The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.	S J Collins	Blood	1987	3311197	No
3481	1210	1210.0	50.5	50.5	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
3482	6046	1209.2	235.0	47.0	KEGG: new perspectives on genomes, pathways, diseases and drugs.	Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima	Nucleic Acids Res	2017	27899662	Yes
3483	1209	1209.0	44.6	44.6	Beyond curriculum reform: confronting medicine's hidden curriculum.	F W Hafferty	Acad Med	1998	9580717	Yes
3484	1209	1209.0	29.8	29.8	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
3485	1209	1209.0	32.3	32.3	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
3486	1209	1209.0	76.2	76.2	Multicollinearity and misleading statistical results.	Jong Hae Kim	Korean J Anesthesiol	2019	31304696	Yes
3487	2417	1208.5	42.6	21.3	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
3488	1208	1208.0	38.3	38.3	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
3489	1208	1208.0	26.2	26.2	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
3490	1208	1208.0	25.0	25.0	Twilight zone of protein sequence alignments.	B Rost	Protein Eng	1999	10195279	Yes
3491	2416	1208.0	43.7	21.9	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3492	1208	1208.0	10.0	10.0	A New Serum Type System In Man--The Lp System.	K BERG	Acta Pathol Microbiol Scand	1963	14064818	Yes
3493	2416	1208.0	56.6	28.3	Quorum sensing: cell-to-cell communication in bacteria.	Christopher M Waters, Bonnie L Bassler	Annu Rev Cell Dev Biol	2005	16212498	No
3494	1208	1208.0	35.1	35.1	On the mechanisms of biocompatibility.	David F Williams	Biomaterials	2008	18440630	No
3495	1208	1208.0	32.1	32.1	Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.	Gregg L Semenza	Trends Pharmacol Sci	2012	22398146	No
3496	1208	1208.0	52.9	52.9	Using Bayes to get the most out of non-significant results.	Zoltan Dienes	Front Psychol	2014	25120503	Yes
3497	4831	1207.8	123.7	30.9	Gene ontology analysis for RNA-seq: accounting for selection bias.	Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack	Genome Biol	2010	20132535	Yes
3498	3622	1207.3	175.5	58.5	Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study.	Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas	Nurs Health Sci	2013	23480423	No
3499	1207	1207.0	44.8	44.8	Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).	F Berenbaum	Osteoarthritis Cartilage	2013	23194896	No
3500	3620	1206.7	91.7	30.6	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
3501	2413	1206.5	105.8	52.9	Problems and proposals for recording gingivitis and plaque.	J Ainamo, I Bay	Int Dent J	1975	1058834	Yes
3502	3619	1206.3	162.5	54.2	The NLRP3 inflammasome: molecular activation and regulation to therapeutics.	Karen V Swanson, Meng Deng, Jenny P-Y Ting	Nat Rev Immunol	2019	31036962	No
3503	1206	1206.0	33.4	33.4	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
3504	1206	1206.0	18.1	18.1	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
3505	1206	1206.0	27.8	27.8	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
3506	1206	1206.0	22.3	22.3	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
3507	2412	1206.0	67.9	34.0	Reactive oxygen species, cellular redox systems, and apoptosis.	Magdalena L Circu, Tak Yee Aw	Free Radic Biol Med	2010	20045723	No
3508	2411	1205.5	58.9	29.4	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
3509	2411	1205.5	82.6	41.3	Superoxide dismutases: I. Occurrence in higher plants.	C N Giannopolitis, S K Ries	Plant Physiol	1977	16659839	Yes
3510	2410	1205.0	87.0	43.5	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
3511	2410	1205.0	95.5	47.8	A real-time QRS detection algorithm.	J Pan, W J Tompkins	IEEE Trans Biomed Eng	1985	3997178	Yes
3512	1205	1205.0	41.2	41.2	Assay of intestinal disaccharidases.	A Dahlqvist	Anal Biochem	1968	5636962	Yes
3513	2410	1205.0	52.8	26.4	Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.	T Hunter, B M Sefton	Proc Natl Acad Sci U S A	1980	6246487	Yes
3514	1205	1205.0	19.3	19.3	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
3515	2409	1204.5	168.7	84.3	TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy.	Jan P Meier-Kolthoff, Markus Goker	Nat Commun	2019	31097708	Yes
3516	3613	1204.3	72.4	24.1	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
3517	1204	1204.0	32.8	32.8	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
3518	1204	1204.0	25.4	25.4	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
3519	1204	1204.0	44.2	44.2	Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes.	Walter S Leal	Annu Rev Entomol	2013	23020622	No
3520	2407	1203.5	75.4	37.7	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
3521	2407	1203.5	49.8	24.9	Roles of CHOP/GADD153 in endoplasmic reticulum stress.	S Oyadomari, M Mori	Cell Death Differ	2004	14685163	No
3522	2407	1203.5	116.1	58.0	Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis.	Laura M Doyle, Michael Zhuo Wang	Cells	2019	31311206	No
3523	3610	1203.3	109.7	36.6	The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.	G Blessed, B E Tomlinson, M Roth	Br J Psychiatry	1968	5662937	Yes
3524	3610	1203.3	108.3	36.1	Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.	Irith Wiegand, Kai Hilpert, Robert E W Hancock	Nat Protoc	2008	18274517	Yes
3525	7219	1203.2	242.2	40.4	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
3526	1203	1203.0	36.6	36.6	Biosynthesis and metabolism of endothelium-derived nitric oxide.	L J Ignarro	Annu Rev Pharmacol Toxicol	1990	2188578	No
3527	2406	1203.0	50.9	25.4	Regeneration beyond the glial scar.	Jerry Silver, Jared H Miller	Nat Rev Neurosci	2004	14735117	No
3528	6013	1202.6	190.9	38.2	A simulation study of the number of events per variable in logistic regression analysis.	P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein	J Clin Epidemiol	1996	8970487	Yes
3529	2405	1202.5	77.7	38.9	Quantitative determination of serum triglycerides by the use of enzymes.	G Bucolo, H David	Clin Chem	1973	4703655	Yes
3530	6012	1202.4	141.9	28.4	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
3531	6011	1202.2	267.7	53.5	VSEARCH: a versatile open source tool for metagenomics.	Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic Mahe	PeerJ	2016	27781170	Yes
3532	1202	1202.0	49.1	49.1	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
3533	1202	1202.0	29.7	29.7	Hereditary cancer, oncogenes, and antioncogenes.	A G Knudson	Cancer Res	1985	2983882	Yes
3534	1202	1202.0	44.1	44.1	Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error.	J T Daugirdas	J Am Soc Nephrol	1993	8305648	Yes
3535	1202	1202.0	32.6	32.6	The mechanisms of alloxan- and streptozotocin-induced diabetes.	S Lenzen	Diabetologia	2008	18087688	No
3536	7211	1201.8	151.0	25.2	Obesity is associated with macrophage accumulation in adipose tissue.	Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante	J Clin Invest	2003	14679176	Yes
3537	2403	1201.5	40.8	20.4	A synthetic oscillatory network of transcriptional regulators.	M B Elowitz, S Leibler	Nature	2000	10659856	Yes
3538	2402	1201.0	52.3	26.1	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3539	1201	1201.0	40.6	40.6	The pain self-efficacy questionnaire: Taking pain into account.	Michael K Nicholas	Eur J Pain	2007	16446108	Yes
3540	4804	1201.0	122.3	30.6	Mussel-inspired surface chemistry for multifunctional coatings.	Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith	Science	2007	17947576	Yes
3541	1200	1200.0	37.8	37.8	The pathogenesis of sepsis.	R C Bone	Ann Intern Med	1991	1872494	No
3542	1200	1200.0	24.6	24.6	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
3543	2400	1200.0	56.0	28.0	Adipocytokines: mediators linking adipose tissue, inflammation and immunity.	Herbert Tilg, Alexander R Moschen	Nat Rev Immunol	2006	16998510	No
3544	1200	1200.0	30.4	30.4	Neuronal gamma-band synchronization as a fundamental process in cortical computation.	Pascal Fries	Annu Rev Neurosci	2009	19400723	No
3545	1200	1200.0	26.1	26.1	Structure and signalling in the IL-17 receptor family.	Sarah L Gaffen	Nat Rev Immunol	2009	19575028	No
3546	3600	1200.0	101.9	34.0	Macrophage biology in development, homeostasis and disease.	Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard	Nature	2013	23619691	No
3547	4799	1199.8	114.6	28.6	Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.	Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon	Proc Natl Acad Sci U S A	2003	12506194	Yes
3548	4796	1199.0	107.0	26.8	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
3549	1199	1199.0	36.6	36.6	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
3550	1199	1199.0	22.3	22.3	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
3551	1199	1199.0	46.6	46.6	Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A).	Laura J Julian	Arthritis Care Res (Hoboken)	2011	22588767	No
3552	2398	1199.0	87.5	43.8	OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy.	David M Emms, Steven Kelly	Genome Biol	2015	26243257	Yes
3553	10787	1198.6	351.4	39.0	A novel potent vasoconstrictor peptide produced by vascular endothelial cells.	M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki	Nature	1988	2451132	Yes
3554	2397	1198.5	48.1	24.1	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
3555	2397	1198.5	64.4	32.2	Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.	Amit Etkin, Tor D Wager	Am J Psychiatry	2007	17898336	Yes
3556	2397	1198.5	106.9	53.5	Neurobiology of addiction: a neurocircuitry analysis.	George F Koob, Nora D Volkow	Lancet Psychiatry	2016	27475769	No
3557	1198	1198.0	39.4	39.4	beta-Lactamases in laboratory and clinical resistance.	D M Livermore	Clin Microbiol Rev	1995	8665470	No
3558	1198	1198.0	34.9	34.9	Social cognition and the brain: a meta-analysis.	Frank Van Overwalle	Hum Brain Mapp	2009	18381770	Yes
3559	1198	1198.0	24.4	24.4	Serine/threonine phosphatases: mechanism through structure.	Yigong Shi	Cell	2009	19879837	No
3560	3594	1198.0	138.9	46.3	Rheumatoid arthritis.	Josef S Smolen, Daniel Aletaha, Iain B McInnes	Lancet	2016	27156434	No
3561	2395	1197.5	101.4	50.7	Network analysis: an integrative approach to the structure of psychopathology.	Denny Borsboom, Angelique O J Cramer	Annu Rev Clin Psychol	2013	23537483	No
3562	11971	1197.1	262.6	26.3	Scalable molecular dynamics with NAMD.	James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus Schulten	J Comput Chem	2005	16222654	Yes
3563	1197	1197.0	56.7	56.7	The sociological study of stress.	L I Pearlin	J Health Soc Behav	1989	2674272	No
3564	1197	1197.0	32.3	32.3	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
3565	1197	1197.0	34.0	34.0	Social support and patient adherence to medical treatment: a meta-analysis.	M Robin DiMatteo	Health Psychol	2004	15008666	Yes
3566	1197	1197.0	35.7	35.7	The Danish Cancer Registry.	Marianne Lundkjaer Gjerstorff	Scand J Public Health	2011	21775350	Yes
3567	8378	1196.9	160.2	22.9	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
3568	2393	1196.5	61.7	30.9	The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.	Maria M Mihaylova, Reuben J Shaw	Nat Cell Biol	2011	21892142	No
3569	1196	1196.0	40.0	40.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
3570	1196	1196.0	28.3	28.3	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
3571	1196	1196.0	21.3	21.3	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
3572	1196	1196.0	45.3	45.3	Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.	H V Gelboin	Physiol Rev	1980	7001511	No
3573	1196	1196.0	29.4	29.4	Unequal treatment: confronting racial and ethnic disparities in health care.	Alan Nelson	J Natl Med Assoc	2002	12152921	No
3574	1196	1196.0	25.1	25.1	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
3575	1196	1196.0	41.4	41.4	Autonomic nervous system activity in emotion: a review.	Sylvia D Kreibig	Biol Psychol	2010	20371374	No
3576	1196	1196.0	32.6	32.6	Cyclin-dependent kinases.	Marcos Malumbres	Genome Biol	2014	25180339	No
3577	3585	1195.0	93.9	31.3	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
3578	1195	1195.0	28.8	28.8	Fibrinogen and fibrin structure and functions.	M W Mosesson	J Thromb Haemost	2005	16102057	No
3579	1195	1195.0	30.8	30.8	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
3580	1195	1195.0	23.4	23.4	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
3581	2388	1194.0	37.6	18.8	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
3582	1194	1194.0	20.9	20.9	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
3583	1194	1194.0	22.2	22.2	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
3584	1194	1194.0	22.0	22.0	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
3585	2388	1194.0	48.6	24.3	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
3586	2388	1194.0	59.5	29.8	Cancer epigenetics: from mechanism to therapy.	Mark A Dawson, Tony Kouzarides	Cell	2012	22770212	No
3587	2387	1193.5	202.4	101.2	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
3588	1193	1193.0	39.2	39.2	Spin trapping: ESR parameters of spin adducts.	G R Buettner	Free Radic Biol Med	1987	2826304	No
3589	1193	1193.0	27.4	27.4	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3590	2386	1193.0	52.2	26.1	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
3591	1193	1193.0	23.0	23.0	Preliminary Trial Of Carisoprodol In Multiple Sclerosis.	B ASHWORTH	Practitioner	1964	14143329	Yes
3592	1193	1193.0	27.2	27.2	Differential projections of the infralimbic and prelimbic cortex in the rat.	Robert P Vertes	Synapse	2004	14579424	Yes
3593	1193	1193.0	27.1	27.1	Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.	Thomas A Wynn	J Clin Invest	2007	17332879	No
3594	3577	1192.3	71.5	23.8	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
3595	1192	1192.0	68.0	68.0	Nontuberculous mycobacteria and associated diseases.	E Wolinsky	Am Rev Respir Dis	1979	369415	No
3596	2384	1192.0	95.4	47.7	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
3597	1192	1192.0	26.5	26.5	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
3598	3576	1192.0	91.0	30.3	Fluorine in pharmaceuticals: looking beyond intuition.	Klaus Muller, Christoph Faeh, Francois Diederich	Science	2007	17901324	No
3599	2384	1192.0	63.4	31.7	Strategies in the design of nanoparticles for therapeutic applications.	Robby A Petros, Joseph M DeSimone	Nat Rev Drug Discov	2010	20616808	No
3600	1192	1192.0	32.8	32.8	Cellular and molecular mechanisms of renal fibrosis.	Youhua Liu	Nat Rev Nephrol	2011	22009250	No
3601	2384	1192.0	73.2	36.6	Photoacoustic tomography: in vivo imaging from organelles to organs.	Lihong V Wang, Song Hu	Science	2012	22442475	No
3602	1191	1191.0	31.1	31.1	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
3603	1191	1191.0	34.1	34.1	Determinants of tumor blood flow: a review.	R K Jain	Cancer Res	1988	3282647	No
3604	1191	1191.0	11.6	11.6	Pathologic anatomy of the pancreas in juvenile diabetes mellitus.	W Gepts	Diabetes	1965	5318831	Yes
3605	1191	1191.0	29.4	29.4	Epidemiology of urinary tract infections: incidence, morbidity, and economic costs.	Betsy Foxman	Am J Med	2002	12113866	No
3606	2382	1191.0	64.4	32.2	Burden of major musculoskeletal conditions.	Anthony D Woolf, Bruce Pfleger	Bull World Health Organ	2003	14710506	No
3607	1191	1191.0	0.0	0.0	Histological demonstration of mucin after periodic acid.	J F A McMANUS	Nature	1946	20995486	Yes
3608	2382	1191.0	57.4	28.7	Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.	Sophia Y Lunt, Matthew G Vander Heiden	Annu Rev Cell Dev Biol	2011	21985671	No
3609	1191	1191.0	60.6	60.6	Cisplatin: The first metal based anticancer drug.	Sumit Ghosh	Bioorg Chem	2019	31003078	No
3610	1190	1190.0	0.0	0.0	The powerful placebo.	H K BEECHER	J Am Med Assoc	1955	13271123	Yes
3611	1190	1190.0	23.4	23.4	The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma.	W G DUNCOMBE	Clin Chim Acta	1964	14122498	Yes
3612	1190	1190.0	35.3	35.3	Chronic stress, drug use, and vulnerability to addiction.	Rajita Sinha	Ann N Y Acad Sci	2008	18991954	No
3613	1190	1190.0	40.0	40.0	T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.	Shane Crotty	Immunity	2019	31117010	No
3614	3568	1189.3	96.4	32.1	Spirometric reference values from a sample of the general U.S. population.	J L Hankinson, J R Odencrantz, K B Fedan	Am J Respir Crit Care Med	1999	9872837	Yes
3615	3568	1189.3	121.0	40.3	The weirdest people in the world?	Joseph Henrich, Steven J Heine, Ara Norenzayan	Behav Brain Sci	2010	20550733	Yes
3616	13080	1189.1	426.1	38.7	A global reference for human genetic variation.	, Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R Abecasis	Nature	2015	26432245	Yes
3617	2378	1189.0	56.5	28.2	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
3618	1189	1189.0	35.2	35.2	Lumbar disc disorders and low-back pain: socioeconomic factors and consequences.	Jeffrey N Katz	J Bone Joint Surg Am	2006	16595438	No
3619	1189	1189.0	27.5	27.5	Ab-initio simulations of materials using VASP: Density-functional theory and beyond.	Jurgen Hafner	J Comput Chem	2008	18623101	Yes
3620	2378	1189.0	51.2	25.6	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
3621	4755	1188.8	109.2	27.3	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
3622	1188	1188.0	34.4	34.4	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
3623	1188	1188.0	39.8	39.8	Constructive and unconstructive repetitive thought.	Edward R Watkins	Psychol Bull	2008	18298268	No
3624	3563	1187.7	118.1	39.4	The MaxQuant computational platform for mass spectrometry-based shotgun proteomics.	Stefka Tyanova, Tikira Temu, Juergen Cox	Nat Protoc	2016	27809316	Yes
3625	4748	1187.0	89.1	22.3	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
3626	2373	1186.5	85.0	42.5	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3627	2373	1186.5	88.3	44.1	Epidemiology of adult fractures: A review.	Charles M Court-Brown, Ben Caesar	Injury	2006	16814787	No
3628	2372	1186.0	110.7	55.4	Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.	J D Peuler, G A Johnson	Life Sci	1977	904439	Yes
3629	1186	1186.0	34.6	34.6	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
3630	1186	1186.0	26.1	26.1	Sjögren's syndrome.	Robert I Fox	Lancet	2005	16039337	No
3631	1186	1186.0	28.4	28.4	Pathogenesis of osteoporosis: concepts, conflicts, and prospects.	Lawrence G Raisz	J Clin Invest	2005	16322775	No
3632	1186	1186.0	34.0	34.0	Lanthanide luminescence for biomedical analyses and imaging.	Jean-Claude G Bunzli	Chem Rev	2010	20151630	No
3633	2372	1186.0	90.9	45.5	Shared decision making--pinnacle of patient-centered care.	Michael J Barry, Susan Edgman-Levitan	N Engl J Med	2012	22375967	Yes
3634	2372	1186.0	68.1	34.0	Long non-coding RNAs: new players in cell differentiation and development.	Alessandro Fatica, Irene Bozzoni	Nat Rev Genet	2014	24296535	No
3635	16603	1185.9	350.2	25.0	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
3636	3557	1185.7	75.6	25.2	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
3637	3557	1185.7	69.9	23.3	Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips.	Juri Rappsilber, Matthias Mann, Yasushi Ishihama	Nat Protoc	2007	17703201	Yes
3638	3557	1185.7	113.1	37.7	The Danish National Patient Register.	Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka Rebolj	Scand J Public Health	2011	21775347	Yes
3639	5927	1185.4	190.6	38.1	Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.	D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum	N Engl J Med	1989	2648148	No
3640	1185	1185.0	33.2	33.2	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
3641	1185	1185.0	30.7	30.7	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
3642	2370	1185.0	49.8	24.9	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
3643	1185	1185.0	57.8	57.8	Resin composite--state of the art.	Jack L Ferracane	Dent Mater	2011	21093034	No
3644	1184	1184.0	39.0	39.0	Interleukin-1 and the pathogenesis of the acute-phase response.	C A Dinarello	N Engl J Med	1984	6208485	No
3645	1184	1184.0	36.9	36.9	Predictors of postpartum depression: an update.	C T Beck	Nurs Res	2001	11570712	Yes
3646	1184	1184.0	21.3	21.3	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
3647	1184	1184.0	37.6	37.6	Epidemiology of heart failure.	Veronique L Roger	Circ Res	2013	23989710	No
3648	1184	1184.0	152.5	152.5	Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp.	Shifu Chen	Imeta	2023	38868435	Yes
3649	2367	1183.5	72.8	36.4	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
3650	2367	1183.5	63.0	31.5	The diversity and biogeography of soil bacterial communities.	Noah Fierer, Robert B Jackson	Proc Natl Acad Sci U S A	2006	16407148	Yes
3651	1183	1183.0	36.9	36.9	Molecular biology of steroid hormone synthesis.	W L Miller	Endocr Rev	1988	3061784	No
3652	1183	1183.0	53.0	53.0	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
3653	2366	1183.0	76.8	38.4	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
3654	1183	1183.0	25.9	25.9	What is principal component analysis?	Markus Ringner	Nat Biotechnol	2008	18327243	Yes
3655	1183	1183.0	40.1	40.1	Microbial life in the phyllosphere.	Julia A Vorholt	Nat Rev Microbiol	2012	23154261	No
3656	1183	1183.0	38.8	38.8	The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments.	Peter C Austin	Stat Med	2014	24122911	Yes
3657	5913	1182.6	166.3	33.3	Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research.	Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G Altman	PLoS Biol	2010	20613859	No
3658	2365	1182.5	45.8	22.9	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
3659	3547	1182.3	100.0	33.3	AMPK: a nutrient and energy sensor that maintains energy homeostasis.	D Grahame Hardie, Fiona A Ross, Simon A Hawley	Nat Rev Mol Cell Biol	2012	22436748	No
3660	1182	1182.0	52.9	52.9	Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder.	M Rutter	Br J Psychiatry	1985	3830321	Yes
3661	1182	1182.0	32.4	32.4	Normal bone anatomy and physiology.	Bart Clarke	Clin J Am Soc Nephrol	2008	18988698	No
3662	1182	1182.0	34.0	34.0	Graves' ophthalmopathy.	Rebecca S Bahn	N Engl J Med	2010	20181974	No
3663	18904	1181.5	692.3	43.3	SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.	Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner	J Comput Biol	2012	22506599	Yes
3664	2363	1181.5	59.7	29.9	Molecular mechanisms of T cell co-stimulation and co-inhibition.	Lieping Chen, Dallas B Flies	Nat Rev Immunol	2013	23470321	No
3665	3544	1181.3	70.8	23.6	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
3666	1181	1181.0	30.7	30.7	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3667	2362	1181.0	57.6	28.8	Antibacterial resistance worldwide: causes, challenges and responses.	Stuart B Levy, Bonnie Marshall	Nat Med	2004	15577930	No
3668	1181	1181.0	31.1	31.1	Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life.	Barry Halliwell	Plant Physiol	2006	16760481	Yes
3669	1181	1181.0	29.7	29.7	The complex world of WNT receptor signalling.	Christof Niehrs	Nat Rev Mol Cell Biol	2012	23151663	No
3670	2361	1180.5	64.9	32.5	The low-density lipoprotein pathway and its relation to atherosclerosis.	J L Goldstein, M S Brown	Annu Rev Biochem	1977	197883	No
3671	1180	1180.0	26.6	26.6	Hybridization of denatured RNA transferred or dotted nitrocellulose paper.	P S Thomas	Methods Enzymol	1983	6194404	Yes
3672	2360	1180.0	50.5	25.2	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
3673	1180	1180.0	26.3	26.3	Solid-state nanopores.	Cees Dekker	Nat Nanotechnol	2007	18654264	No
3674	1180	1180.0	45.2	45.2	Inflammatory mechanisms in patients with chronic obstructive pulmonary disease.	Peter J Barnes	J Allergy Clin Immunol	2016	27373322	No
3675	1180	1180.0	43.4	43.4	A polarizing question: do M1 and M2 microglia exist?	Richard M Ransohoff	Nat Neurosci	2016	27459405	No
3676	3539	1179.7	126.7	42.2	Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.	Michael A Postow, Robert Sidlow, Matthew D Hellmann	N Engl J Med	2018	29320654	No
3677	2359	1179.5	49.4	24.7	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
3678	1179	1179.0	43.2	43.2	View through a window may influence recovery from surgery.	R S Ulrich	Science	1984	6143402	Yes
3679	2358	1179.0	42.8	21.4	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
3680	2358	1179.0	46.8	23.4	Fcgamma receptors as regulators of immune responses.	Falk Nimmerjahn, Jeffrey V Ravetch	Nat Rev Immunol	2008	18064051	No
3681	1179	1179.0	90.5	90.5	Complex heatmap visualization.	Zuguang Gu	Imeta	2022	38868715	Yes
3682	2357	1178.5	84.2	42.1	Ferroptosis: Death by Lipid Peroxidation.	Wan Seok Yang, Brent R Stockwell	Trends Cell Biol	2016	26653790	No
3683	1178	1178.0	39.4	39.4	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
3684	1177	1177.0	33.9	33.9	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
3685	1177	1177.0	25.9	25.9	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
3686	1177	1177.0	23.7	23.7	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
3687	3531	1177.0	122.6	40.9	IL-6 in inflammation, immunity, and disease.	Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto	Cold Spring Harb Perspect Biol	2014	25190079	No
3688	1176	1176.0	33.8	33.8	Spatially heterogeneous dynamics in supercooled liquids.	M D Ediger	Annu Rev Phys Chem	2000	11031277	Yes
3689	1175	1175.0	42.0	42.0	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3690	1175	1175.0	26.3	26.3	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
3691	1175	1175.0	28.7	28.7	Redefining oxidative stress.	Dean P Jones	Antioxid Redox Signal	2006	16987039	No
3692	1175	1175.0	35.4	35.4	Staphylococcus epidermidis--the 'accidental' pathogen.	Michael Otto	Nat Rev Microbiol	2009	19609257	No
3693	2349	1174.5	67.1	33.5	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
3694	5872	1174.4	228.4	45.7	MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph.	Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah Lam	Bioinformatics	2015	25609793	Yes
3695	1174	1174.0	26.0	26.0	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
3696	1174	1174.0	0.0	0.0	The Stability of Broken Ends of Chromosomes in Zea Mays.	B McClintock	Genetics	1941	17247004	Yes
3697	1174	1174.0	71.9	71.9	Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares.	Cheng-Hsien Li	Behav Res Methods	2016	26174714	Yes
3698	2347	1173.5	49.2	24.6	Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.	Daniel J Hicklin, Lee M Ellis	J Clin Oncol	2005	15585754	No
3699	1173	1173.0	42.9	42.9	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
3700	1173	1173.0	31.9	31.9	Presynaptic regulation of catecholamine release.	S Z Langer	Biochem Pharmacol	1974	4617579	No
3701	1173	1173.0	11.6	11.6	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
3702	1173	1173.0	32.3	32.3	Regulation of immune responses by prostaglandin E2.	Pawel Kalinski	J Immunol	2012	22187483	No
3703	2345	1172.5	114.0	57.0	Cytokine Storm.	David C Fajgenbaum, Carl H June	N Engl J Med	2020	33264547	No
3704	1172	1172.0	51.8	51.8	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
3705	1172	1172.0	22.2	22.2	Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.	Mats G L Gustafsson	Proc Natl Acad Sci U S A	2005	16141335	Yes
3706	1172	1172.0	46.1	46.1	Root canal irrigants.	Matthias Zehnder	J Endod	2006	16631834	No
3707	1172	1172.0	29.5	29.5	Gibberellin metabolism and its regulation.	Shinjiro Yamaguchi	Annu Rev Plant Biol	2008	18173378	No
3708	3515	1171.7	143.8	47.9	Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.	A DeLean, P J Munson, D Rodbard	Am J Physiol	1978	686171	Yes
3709	2343	1171.5	58.8	29.4	Targeting hypoxia in cancer therapy.	William R Wilson, Michael P Hay	Nat Rev Cancer	2011	21606941	No
3710	2343	1171.5	67.3	33.6	Genome-wide efficient mixed-model analysis for association studies.	Xiang Zhou, Matthew Stephens	Nat Genet	2012	22706312	Yes
3711	2343	1171.5	75.9	38.0	Glycosylation in cancer: mechanisms and clinical implications.	Salome S Pinho, Celso A Reis	Nat Rev Cancer	2015	26289314	No
3712	2342	1171.0	47.2	23.6	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
3713	1171	1171.0	29.8	29.8	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3714	1171	1171.0	24.1	24.1	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
3715	1171	1171.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B REXED	J Comp Neurol	1952	14946260	Yes
3716	1171	1171.0	25.8	25.8	Pathogenesis of atherosclerosis.	Erling Falk	J Am Coll Cardiol	2006	16631513	Yes
3717	5854	1170.8	113.9	22.8	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
3718	2341	1170.5	50.5	25.2	Effect of pegylation on pharmaceuticals.	J Milton Harris, Robert B Chess	Nat Rev Drug Discov	2003	12612647	No
3719	1170	1170.0	19.5	19.5	Evolution and tinkering.	F Jacob	Science	1977	860134	Yes
3720	4680	1170.0	176.4	44.1	The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus.	L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg	Arch Neurol	1989	2803071	Yes
3721	1170	1170.0	35.2	35.2	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
3722	2340	1170.0	52.5	26.2	Efficient behavior of small-world networks.	V Latora, M Marchiori	Phys Rev Lett	2001	11690461	Yes
3723	2339	1169.5	69.7	34.9	Mental rotation of three-dimensional objects.	R N Shepard, J Metzler	Science	1971	5540314	Yes
3724	1169	1169.0	34.7	34.7	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
3725	2338	1169.0	61.6	30.8	The evolution of cooperation.	R Axelrod, W D Hamilton	Science	1981	7466396	Yes
3726	2338	1169.0	88.3	44.1	Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP).	Marta Kutas, Kara D Federmeier	Annu Rev Psychol	2011	20809790	No
3727	1169	1169.0	32.8	32.8	Targeting the DNA Damage Response in Cancer.	Mark J O'Connor	Mol Cell	2015	26590714	No
3728	1168	1168.0	30.5	30.5	Interval estimation for the difference between independent proportions: comparison of eleven methods.	R G Newcombe	Stat Med	1998	9595617	Yes
3729	1168	1168.0	31.2	31.2	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
3730	1168	1168.0	0.0	0.0	Knee joint changes after meniscectomy.	T J FAIRBANK	J Bone Joint Surg Br	1948	18894618	Yes
3731	3502	1167.3	80.6	26.9	Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.	A L Shapiro, E Vinuela, J V Maizel	Biochem Biophys Res Commun	1967	4861258	Yes
3732	1167	1167.0	45.7	45.7	Clinical experience with impedance audiometry.	J Jerger	Arch Otolaryngol	1970	5455571	Yes
3733	1167	1167.0	21.7	21.7	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
3734	2334	1167.0	57.6	28.8	Monocyte recruitment during infection and inflammation.	Chao Shi, Eric G Pamer	Nat Rev Immunol	2011	21984070	No
3735	2333	1166.5	56.8	28.4	The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.	Laetitia Prut, Catherine Belzung	Eur J Pharmacol	2003	12600700	No
3736	3499	1166.3	136.0	45.3	Concurrent and predictive validity of a self-reported measure of medication adherence.	D E Morisky, L W Green, D M Levine	Med Care	1986	3945130	Yes
3737	1165	1165.0	26.6	26.6	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
3738	1165	1165.0	40.2	40.2	Development of the practice environment scale of the Nursing Work Index.	Eileen T Lake	Res Nurs Health	2002	12015780	Yes
3739	1165	1165.0	0.0	0.0	A chemical method for the determination of oestriol, oestrone and oestradiol in human urine.	J B BROWN	Biochem J	1955	14389222	Yes
3740	2330	1165.0	56.7	28.4	Anemia of chronic disease.	Guenter Weiss, Lawrence T Goodnough	N Engl J Med	2005	15758012	No
3741	1164	1164.0	21.3	21.3	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
3742	4656	1164.0	108.3	27.1	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
3743	1164	1164.0	23.1	23.1	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
3744	3491	1163.7	77.4	25.8	STATs in cancer inflammation and immunity: a leading role for STAT3.	Hua Yu, Drew Pardoll, Richard Jove	Nat Rev Cancer	2009	19851315	No
3745	2327	1163.5	47.8	23.9	Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.	Javier A Menendez, Ruth Lupu	Nat Rev Cancer	2007	17882277	No
3746	2327	1163.5	57.5	28.8	Sterile inflammation: sensing and reacting to damage.	Grace Y Chen, Gabriel Nunez	Nat Rev Immunol	2010	21088683	No
3747	1163	1163.0	24.4	24.4	Molecular cloning and expression of glycogen synthase kinase-3/factor A.	J R Woodgett	EMBO J	1990	2164470	Yes
3748	1163	1163.0	20.4	20.4	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3749	1163	1163.0	34.8	34.8	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
3750	1163	1163.0	34.8	34.8	Recommended effect size statistics for repeated measures designs.	Roger Bakeman	Behav Res Methods	2005	16405133	Yes
3751	1163	1163.0	0.0	0.0	Observations on the isolated phrenic nerve diaphragm preparation of the rat.	E BULBRING	Br J Pharmacol Chemother	1946	20999334	Yes
3752	6977	1162.8	176.2	29.4	The capsaicin receptor: a heat-activated ion channel in the pain pathway.	M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius	Nature	1997	9349813	Yes
3753	5814	1162.8	283.2	56.6	UFBoot2: Improving the Ultrafast Bootstrap Approximation.	Diep Thi Hoang, Olga Chernomor, Arndt von Haeseler, Bui Quang Minh, Le Sy Vinh	Mol Biol Evol	2018	29077904	Yes
3754	2325	1162.5	51.1	25.6	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
3755	2325	1162.5	55.8	27.9	An improved general amino acid replacement matrix.	Si Quang Le, Olivier Gascuel	Mol Biol Evol	2008	18367465	Yes
3756	6973	1162.2	178.5	29.8	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
3757	1162	1162.0	20.4	20.4	Biogenic amines and the states of sleep.	M Jouvet	Science	1969	4303225	No
3758	1162	1162.0	27.2	27.2	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3759	1162	1162.0	0.0	0.0	The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease.	J VAGUE	Am J Clin Nutr	1956	13282851	Yes
3760	1162	1162.0	33.4	33.4	Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators.	Bruce S McEwen	Eur J Pharmacol	2008	18282566	No
3761	1162	1162.0	47.7	47.7	How Many Subjects Does It Take To Do A Regression Analysis.	S B Green	Multivariate Behav Res	1991	26776715	Yes
3762	1161	1161.0	24.2	24.2	Toward self-organization and complex matter.	Jean-Marie Lehn	Science	2002	11923524	Yes
3763	1161	1161.0	29.0	29.0	Physiology and immunology of the cholinergic antiinflammatory pathway.	Kevin J Tracey	J Clin Invest	2007	17273548	No
3764	1161	1161.0	32.3	32.3	Conceptual synthesis in community ecology.	Mark Vellend	Q Rev Biol	2010	20565040	No
3765	1161	1161.0	43.9	43.9	Epithelial Mesenchymal Transition in Tumor Metastasis.	Vivek Mittal	Annu Rev Pathol	2018	29414248	No
3766	2321	1160.5	77.2	38.6	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudas	N Engl J Med	1992	1307234	Yes
3767	3481	1160.3	82.3	27.4	Pathogenic Escherichia coli.	James B Kaper, James P Nataro, Harry L Mobley	Nat Rev Microbiol	2004	15040260	No
3768	1160	1160.0	31.3	31.3	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
3769	2320	1160.0	41.5	20.8	AP-1 as a regulator of cell life and death.	Eitan Shaulian, Michael Karin	Nat Cell Biol	2002	11988758	No
3770	1160	1160.0	24.5	24.5	Antimicrobial reactive oxygen and nitrogen species: concepts and controversies.	Ferric C Fang	Nat Rev Microbiol	2004	15378046	No
3771	3479	1159.7	101.8	33.9	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3772	2319	1159.5	66.2	33.1	Growth of a rat neuroblastoma cell line in serum-free supplemented medium.	J E Bottenstein, G H Sato	Proc Natl Acad Sci U S A	1979	284369	Yes
3773	2319	1159.5	47.0	23.5	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
3774	2319	1159.5	43.0	21.5	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
3775	1159	1159.0	36.9	36.9	Subjective well-being. The science of happiness and a proposal for a national index.	E Diener	Am Psychol	2000	11392863	Yes
3776	2318	1159.0	131.0	65.5	Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.	R W BUTCHER, E W SUTHERLAND	J Biol Chem	1962	13875173	Yes
3777	1159	1159.0	30.5	30.5	A perspective on judgment and choice: mapping bounded rationality.	Daniel Kahneman	Am Psychol	2003	14584987	No
3778	2318	1159.0	50.3	25.1	Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.	Sharon R Browning, Brian L Browning	Am J Hum Genet	2007	17924348	Yes
3779	5793	1158.6	197.8	39.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	Open Med	2009	21603045	Yes
3780	2317	1158.5	73.2	36.6	Positive psychology. An introduction.	M E Seligman, M Csikszentmihalyi	Am Psychol	2000	11392865	Yes
3781	1158	1158.0	31.0	31.0	Diseases of the mitochondrial DNA.	D C Wallace	Annu Rev Biochem	1992	1497308	No
3782	3474	1158.0	73.0	24.3	A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.	M Serrano, G J Hannon, D Beach	Nature	1993	8259215	Yes
3783	1158	1158.0	44.2	44.2	Gait changes in older adults: predictors of falls or indicators of fear.	B E Maki	J Am Geriatr Soc	1997	9063277	Yes
3784	1158	1158.0	37.4	37.4	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3785	1158	1158.0	24.6	24.6	Liver regeneration.	George K Michalopoulos	J Cell Physiol	2007	17559071	No
3786	1158	1158.0	0.0	0.0	A new microscopic principle.	D GABOR	Nature	1948	18860291	Yes
3787	4632	1158.0	203.8	51.0	Random effects structure for confirmatory hypothesis testing: Keep it maximal.	Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily	J Mem Lang	2013	24403724	Yes
3788	2314	1157.0	70.3	35.1	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
3789	1157	1157.0	21.0	21.0	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
3790	2314	1157.0	54.1	27.1	Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation.	Ivica Letunic, Peer Bork	Bioinformatics	2007	17050570	Yes
3791	1157	1157.0	24.3	24.3	The action potential in mammalian central neurons.	Bruce P Bean	Nat Rev Neurosci	2007	17514198	No
3792	1156	1156.0	24.3	24.3	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
3793	2312	1156.0	0.0	0.0	Cortisone in ulcerative colitis; final report on a therapeutic trial.	S C TRUELOVE, L J WITTS	Br Med J	1955	13260656	Yes
3794	1156	1156.0	33.1	33.1	The broaden-and-build theory of positive emotions.	Barbara L Fredrickson	Philos Trans R Soc Lond B Biol Sci	2004	15347528	No
3795	1156	1156.0	32.8	32.8	The social brain in adolescence.	Sarah-Jayne Blakemore	Nat Rev Neurosci	2008	18354399	No
3796	1156	1156.0	43.9	43.9	Reference methods for the assessment of physical characteristics of meat.	K O Honikel	Meat Sci	1998	22060626	Yes
3797	1156	1156.0	34.4	34.4	The enteric nervous system and neurogastroenterology.	John B Furness	Nat Rev Gastroenterol Hepatol	2012	22392290	No
3798	3467	1155.7	83.7	27.9	High resolution two-dimensional electrophoresis of basic as well as acidic proteins.	P Z O'Farrell, H M Goodman, P H O'Farrell	Cell	1977	23215	Yes
3799	2311	1155.5	45.4	22.7	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No
3800	1155	1155.0	41.1	41.1	Attention, similarity, and the identification-categorization relationship.	R M Nosofsky	J Exp Psychol Gen	1986	2937873	Yes
3801	1155	1155.0	28.1	28.1	Selective coronary arteriography. I. A percutaneous transfemoral technic.	M P Judkins	Radiology	1967	6048074	Yes
3802	2310	1155.0	66.9	33.5	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
3803	1155	1155.0	27.2	27.2	Looking into the functional architecture of the brain with diffusion MRI.	Denis Le Bihan	Nat Rev Neurosci	2003	12778119	No
3804	1155	1155.0	0.0	0.0	A sensitive method for the assay of 5-hydroxytryptamine.	J R VANE	Br J Pharmacol Chemother	1957	13460242	Yes
3805	1155	1155.0	32.4	32.4	Distracted and confused?: selective attention under load.	Nilli Lavie	Trends Cogn Sci	2005	15668100	No
3806	1155	1155.0	27.7	27.7	Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.	Christof M Niemeyer	Angew Chem Int Ed Engl	2001	29712109	No
3807	2309	1154.5	92.4	46.2	The aggression questionnaire.	A H Buss, M Perry	J Pers Soc Psychol	1992	1403624	Yes
3808	2308	1154.0	60.5	30.2	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
3809	1154	1154.0	23.3	23.3	Differentiation and proliferation of hematopoietic stem cells.	M Ogawa	Blood	1993	8499622	No
3810	2308	1154.0	58.8	29.4	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
3811	1154	1154.0	26.4	26.4	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	M M Tirion	Phys Rev Lett	1996	10063201	Yes
3812	1154	1154.0	24.0	24.0	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3813	1154	1154.0	41.5	41.5	Surface-enhanced Raman spectroscopy: concepts and chemical applications.	Sebastian Schlucker	Angew Chem Int Ed Engl	2014	24711218	Yes
3814	2308	1154.0	124.2	62.1	miRDB: an online database for prediction of functional microRNA targets.	Yuhao Chen, Xiaowei Wang	Nucleic Acids Res	2020	31504780	Yes
3815	2306	1153.0	53.4	26.7	Cellular uptake of the tat protein from human immunodeficiency virus.	A D Frankel, C O Pabo	Cell	1988	2849510	Yes
3816	1153	1153.0	33.4	33.4	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
3817	1153	1153.0	37.9	37.9	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
3818	1153	1153.0	38.3	38.3	Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world.	Murray B Isman	Annu Rev Entomol	2006	16332203	No
3819	6915	1152.5	187.3	31.2	Mild cognitive impairment: clinical characterization and outcome.	R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen	Arch Neurol	1999	10190820	Yes
3820	2305	1152.5	82.8	41.4	The blood-brain barrier.	Richard Daneman, Alexandre Prat	Cold Spring Harb Perspect Biol	2015	25561720	No
3821	1152	1152.0	24.0	24.0	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
3822	1152	1152.0	31.4	31.4	Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations.	A E Black	Int J Obes Relat Metab Disord	2000	11033980	Yes
3823	1152	1152.0	24.1	24.1	Pyramidal neurons: dendritic structure and synaptic integration.	Nelson Spruston	Nat Rev Neurosci	2008	18270515	No
3824	2302	1151.0	48.4	24.2	Plasminogen: purification from human plasma by affinity chromatography.	D G Deutsch, E T Mertz	Science	1970	5475635	Yes
3825	1151	1151.0	26.4	26.4	BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data.	O Gascuel	Mol Biol Evol	1997	9254330	Yes
3826	1151	1151.0	26.8	26.8	Area deprivation and widening inequalities in US mortality, 1969-1998.	Gopal K Singh	Am J Public Health	2003	12835199	Yes
3827	2302	1151.0	64.9	32.5	Extended-spectrum beta-lactamases: a clinical update.	David L Paterson, Robert A Bonomo	Clin Microbiol Rev	2005	16223952	No
3828	1151	1151.0	0.0	0.0	The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume.	C D Murray	Proc Natl Acad Sci U S A	1926	16576980	Yes
3829	1151	1151.0	27.4	27.4	The role of acetylcholine in learning and memory.	Michael E Hasselmo	Curr Opin Neurobiol	2006	17011181	No
3830	20715	1150.8	488.9	27.2	PHENIX: a comprehensive Python-based system for macromolecular structure solution.	Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart	Acta Crystallogr D Biol Crystallogr	2010	20124702	Yes
3831	13805	1150.4	408.2	34.0	Ferroptosis: an iron-dependent form of nonapoptotic cell death.	Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang, Barclay Morrison, Brent R Stockwell	Cell	2012	22632970	Yes
3832	4601	1150.2	98.2	24.6	Isolation and characterization of exosomes from cell culture supernatants and biological fluids.	Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled Clayton	Curr Protoc Cell Biol	2006	18228490	Yes
3833	2300	1150.0	86.4	43.2	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3834	1150	1150.0	32.5	32.5	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
3835	1150	1150.0	32.2	32.2	Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse.	S Irwin	Psychopharmacologia	1968	5679627	Yes
3836	3450	1150.0	82.8	27.6	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
3837	1150	1150.0	20.3	20.3	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
3838	1150	1150.0	27.0	27.0	Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.	Mark E Bouton	Biol Psychiatry	2002	12437938	No
3839	1150	1150.0	45.5	45.5	Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review.	Hannah R Snyder	Psychol Bull	2013	22642228	No
3840	2298	1149.0	46.7	23.4	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
3841	1149	1149.0	31.9	31.9	DNA topoisomerases.	M Gellert	Annu Rev Biochem	1981	6267993	No
3842	1149	1149.0	24.0	24.0	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
3843	1149	1149.0	240.0	240.0	ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns.	Malik Sallam	Healthcare (Basel)	2023	36981544	No
3844	4595	1148.8	34.2	8.6	The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.	P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLME	Lancet	1963	13990765	Yes
3845	3445	1148.3	87.5	29.2	Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.	M K Parmar, V Torri, L Stewart	Stat Med	1998	9921604	Yes
3846	2296	1148.0	44.5	22.2	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
3847	1148	1148.0	34.4	34.4	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
3848	2296	1148.0	59.4	29.7	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
3849	1148	1148.0	28.5	28.5	Glutathione and its role in cellular functions.	H Sies	Free Radic Biol Med	1999	10569624	No
3850	1148	1148.0	26.7	26.7	Metagenomics: application of genomics to uncultured microorganisms.	Jo Handelsman	Microbiol Mol Biol Rev	2004	15590779	No
3851	4590	1147.5	146.2	36.5	The cholinergic hypothesis of geriatric memory dysfunction.	R T Bartus, R L Dean, B Beer, A S Lippa	Science	1982	7046051	No
3852	2295	1147.5	58.6	29.3	Cu-catalyzed azide-alkyne cycloaddition.	Morten Meldal, Christian Wenzel Tornoe	Chem Rev	2008	18698735	No
3853	1147	1147.0	21.5	21.5	Structure of chromatin.	R D Kornberg	Annu Rev Biochem	1977	332067	No
3854	1147	1147.0	31.0	31.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
3855	1147	1147.0	37.9	37.9	A measure of anxiety symptoms among children.	S H Spence	Behav Res Ther	1998	9648330	Yes
3856	2293	1146.5	88.7	44.4	Hearing lips and seeing voices.	H McGurk, J MacDonald	Nature	1976	1012311	Yes
3857	2293	1146.5	45.5	22.8	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3858	2293	1146.5	163.6	81.8	Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?	Fangda Leng, Paul Edison	Nat Rev Neurol	2021	33318676	No
3859	3439	1146.3	81.4	27.1	In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.	Chun-Chi Liang, Ann Y Park, Jun-Lin Guan	Nat Protoc	2007	17406593	Yes
3860	1146	1146.0	20.5	20.5	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	R A Frye	Biochem Biophys Res Commun	2000	10873683	Yes
3861	2292	1146.0	41.4	20.7	Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method.	R Daniel Gietz, Robin A Woods	Methods Enzymol	2002	12073338	Yes
3862	1146	1146.0	29.7	29.7	Ion suppression in mass spectrometry.	Thomas M Annesley	Clin Chem	2003	12816898	No
3863	3436	1145.3	91.4	30.5	Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.	R Schreck, P Rieber, P A Baeuerle	EMBO J	1991	2065663	Yes
3864	1145	1145.0	18.6	18.6	The moulding of senescence by natural selection.	W D Hamilton	J Theor Biol	1966	6015424	Yes
3865	1145	1145.0	27.2	27.2	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
3866	1145	1145.0	32.9	32.9	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
3867	2290	1145.0	0.0	0.0	Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.	H H USSING, K ZERAHN	Acta Physiol Scand	1951	14868510	Yes
3868	1144	1144.0	43.5	43.5	Radioimmunological determination of human C-peptide in serum.	L G Heding	Diabetologia	1975	1239396	Yes
3869	1144	1144.0	20.6	20.6	Shrinkage necrosis: a distinct mode of cellular death.	J F Kerr	J Pathol	1971	4108566	Yes
3870	1144	1144.0	27.3	27.3	Omega-3 fatty acids in inflammation and autoimmune diseases.	Artemis P Simopoulos	J Am Coll Nutr	2002	12480795	No
3871	2288	1144.0	54.7	27.4	The neural basis of decision making.	Joshua I Gold, Michael N Shadlen	Annu Rev Neurosci	2007	17600525	No
3872	2287	1143.5	63.1	31.6	ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control.	Graham Noctor, Christine H. Foyer	Annu Rev Plant Physiol Plant Mol Biol	1998	15012235	Yes
3873	2287	1143.5	63.5	31.8	Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria.	Ivan Sondi, Branka Salopek-Sondi	J Colloid Interface Sci	2004	15158396	Yes
3874	2287	1143.5	113.5	56.8	The neuropathological diagnosis of Alzheimer's disease.	Michael A DeTure, Dennis W Dickson	Mol Neurodegener	2019	31375134	No
3875	1143	1143.0	34.8	34.8	Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice.	D L Coleman	Diabetologia	1978	350680	No
3876	1143	1143.0	31.9	31.9	An improved fluorometric assay for DNA.	R T Hinegardner	Anal Biochem	1971	5544593	Yes
3877	1143	1143.0	26.9	26.9	The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality.	G Hardin	Science	1968	5699198	Yes
3878	2286	1143.0	52.8	26.4	A note on quantifying follow-up in studies of failure time.	M Schemper, T L Smith	Control Clin Trials	1996	8889347	Yes
3879	1143	1143.0	26.1	26.1	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
3880	3428	1142.7	110.1	36.7	Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.	G M Wahl, M Stern, G R Stark	Proc Natl Acad Sci U S A	1979	291033	Yes
3881	7998	1142.6	136.1	19.4	The human genome browser at UCSC.	W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler	Genome Res	2002	12045153	Yes
3882	2285	1142.5	65.8	32.9	Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group.	R J Ginsberg, L V Rubinstein	Ann Thorac Surg	1995	7677489	Yes
3883	4569	1142.2	182.0	45.5	From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites.	Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik Backhed	Cell	2016	27259147	No
3884	1142	1142.0	28.5	28.5	Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.	I J Fidler	Cancer Res	1990	1698118	Yes
3885	1142	1142.0	17.0	17.0	Inherited Antithrombin Deficiency Causing Thrombophilia.	O EGEBERG	Thromb Diath Haemorrh	1965	14347873	Yes
3886	1142	1142.0	26.9	26.9	Soil carbon sequestration impacts on global climate change and food security.	R Lal	Science	2004	15192216	Yes
3887	2284	1142.0	55.7	27.9	Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.	Donald E Owens, Nicholas A Peppas	Int J Pharm	2006	16303268	No
3888	1142	1142.0	22.8	22.8	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
3889	1142	1142.0	28.9	28.9	Descending pathways in motor control.	Roger N Lemon	Annu Rev Neurosci	2008	18558853	No
3890	2284	1142.0	78.0	39.0	Loneliness matters: a theoretical and empirical review of consequences and mechanisms.	Louise C Hawkley, John T Cacioppo	Ann Behav Med	2010	20652462	No
3891	3425	1141.7	106.7	35.6	xCell: digitally portraying the tissue cellular heterogeneity landscape.	Dvir Aran, Zicheng Hu, Atul J Butte	Genome Biol	2017	29141660	Yes
3892	4565	1141.2	156.7	39.2	Development of recommendations for SEMG sensors and sensor placement procedures.	H J Hermens, B Freriks, C Disselhorst-Klug, G Rau	J Electromyogr Kinesiol	2000	11018445	Yes
3893	1141	1141.0	33.5	33.5	Unstable angina. A classification.	E Braunwald	Circulation	1989	2752565	Yes
3894	1141	1141.0	27.8	27.8	DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.	J F Ward	Prog Nucleic Acid Res Mol Biol	1988	3065826	No
3895	4564	1141.0	109.3	27.3	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
3896	1141	1141.0	29.3	29.3	Invited review: Aging and sarcopenia.	Timothy J Doherty	J Appl Physiol (1985)	2003	12970377	No
3897	1141	1141.0	68.1	68.1	Diffusion-in-gel methods for immunological analysis. II.	O OUCHTERLONY	Prog Allergy	1962	14482809	Yes
3898	1141	1141.0	28.9	28.9	Electrogenerated chemiluminescence and its biorelated applications.	Wujian Miao	Chem Rev	2008	18505298	No
3899	1141	1141.0	0.0	0.0	A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations.	R D HOTCHKISS	Arch Biochem	1948	18921848	Yes
3900	2281	1140.5	88.1	44.0	Glutathione reductase.	I Carlberg, B Mannervik	Methods Enzymol	1985	3003504	Yes
3901	1140	1140.0	81.9	81.9	Fibula free flap: a new method of mandible reconstruction.	D A Hidalgo	Plast Reconstr Surg	1989	2734406	Yes
3902	1140	1140.0	27.3	27.3	The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease.	David S Ludwig	JAMA	2002	11988062	No
3903	1140	1140.0	25.8	25.8	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Wurthner	Chem Commun (Camb)	2004	15263926	Yes
3904	5699	1139.8	150.2	30.0	A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?	Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi	Cell	2011	21802130	Yes
3905	2279	1139.5	72.3	36.1	Wine, alcohol, platelets, and the French paradox for coronary heart disease.	S Renaud, M de Lorgeril	Lancet	1992	1351198	Yes
3906	2279	1139.5	138.0	69.0	Modified reagents for determination of urea and ammonia.	A L CHANEY, E P MARBACH	Clin Chem	1962	13878063	Yes
3907	1139	1139.0	25.0	25.0	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
3908	1139	1139.0	16.3	16.3	Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase.	R J PENNINGTON	Biochem J	1961	13734134	Yes
3909	1139	1139.0	42.3	42.3	Fiber and prebiotics: mechanisms and health benefits.	Joanne Slavin	Nutrients	2013	23609775	No
3910	1138	1138.0	56.3	56.3	The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.	G A Ilizarov	Clin Orthop Relat Res	1989	2912628	Yes
3911	2276	1138.0	59.4	29.7	Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.	R A Ignotz, J Massague	J Biol Chem	1986	3456347	Yes
3912	1138	1138.0	11.7	11.7	Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.	J J Hopfield	Proc Natl Acad Sci U S A	1974	4530290	Yes
3913	4552	1138.0	104.1	26.0	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
3914	1138	1138.0	25.9	25.9	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
3915	1138	1138.0	33.3	33.3	The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust.	R Charon	JAMA	2001	11597295	Yes
3916	1138	1138.0	19.3	19.3	5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.	Judith K Christman	Oncogene	2002	12154409	No
3917	1138	1138.0	0.0	0.0	Motivation reconsidered: the concept of competence.	R W WHITE	Psychol Rev	1959	13844397	Yes
3918	5689	1137.8	201.0	40.2	A new clinical scale for the staging of dementia.	C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin	Br J Psychiatry	1982	7104545	Yes
3919	2275	1137.5	85.4	42.7	Visual search and stimulus similarity.	J Duncan, G W Humphreys	Psychol Rev	1989	2756067	Yes
3920	1137	1137.0	35.7	35.7	Biomedical photoacoustic imaging.	Paul Beard	Interface Focus	2011	22866233	Yes
3921	1137	1137.0	49.2	49.2	Psychedelics.	David E Nichols	Pharmacol Rev	2016	26841800	No
3922	2273	1136.5	80.3	40.1	Perceived discrimination and health: a meta-analytic review.	Elizabeth A Pascoe, Laura Smart Richman	Psychol Bull	2009	19586161	Yes
3923	2273	1136.5	80.5	40.2	NAFLD: a multisystem disease.	Christopher D Byrne, Giovanni Targher	J Hepatol	2015	25920090	No
3924	2272	1136.0	45.6	22.8	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
3925	1136	1136.0	39.9	39.9	Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.	W A Catterall	Annu Rev Pharmacol Toxicol	1980	6247957	No
3926	1136	1136.0	41.2	41.2	An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults.	F G Happe	J Autism Dev Disord	1994	8040158	Yes
3927	1136	1136.0	22.7	22.7	Alpha-synuclein and neurodegenerative diseases.	M Goedert	Nat Rev Neurosci	2001	11433374	No
3928	1136	1136.0	0.0	0.0	The stereotaxic method and radiosurgery of the brain.	L LEKSELL	Acta Chir Scand	1951	14914373	Yes
3929	1136	1136.0	36.0	36.0	Mental illness and/or mental health? Investigating axioms of the complete state model of health.	Corey L M Keyes	J Consult Clin Psychol	2005	15982151	Yes
3930	1136	1136.0	0.0	0.0	Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent.	D L Morris	Science	1948	17814729	Yes
3931	1136	1136.0	37.1	37.1	Supramolecular binding thermodynamics by dispersion-corrected density functional theory.	Stefan Grimme	Chemistry	2012	22782805	Yes
3932	2271	1135.5	64.0	32.0	Neural regulation of endocrine and autonomic stress responses.	Yvonne M Ulrich-Lai, James P Herman	Nat Rev Neurosci	2009	19469025	No
3933	1135	1135.0	21.5	21.5	Contingent genetic regulatory events in T lymphocyte activation.	G R Crabtree	Science	1989	2783497	Yes
3934	1135	1135.0	34.6	34.6	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
3935	1135	1135.0	25.2	25.2	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3936	1135	1135.0	31.4	31.4	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
3937	1135	1135.0	23.1	23.1	The mitochondrial genome: structure, transcription, translation and replication.	J W Taanman	Biochim Biophys Acta	1999	10076021	No
3938	1135	1135.0	72.2	72.2	Antimicrobial Resistance: Implications and Costs.	Porooshat Dadgostar	Infect Drug Resist	2019	31908502	No
3939	1134	1134.0	69.1	69.1	Cytoprotection by prostaglandins.	A Robert	Gastroenterology	1979	38173	Yes
3940	2268	1134.0	70.3	35.1	Polymyositis and dermatomyositis (second of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1089199	No
3941	1134	1134.0	33.3	33.3	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
3942	1134	1134.0	21.5	21.5	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
3943	1134	1134.0	26.1	26.1	NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences.	Weihai Ying	Antioxid Redox Signal	2008	18020963	No
3944	1134	1134.0	25.2	25.2	Mucins in cancer: function, prognosis and therapy.	Donald W Kufe	Nat Rev Cancer	2009	19935676	No
3945	3401	1133.7	72.8	24.3	Mitochondria, oxidants, and aging.	Robert S Balaban, Shino Nemoto, Toren Finkel	Cell	2005	15734681	No
3946	3400	1133.3	93.2	31.1	Cytochemical identification of monocytes and granulocytes.	L T Yam, C Y Li, W H Crosby	Am J Clin Pathol	1971	5549896	Yes
3947	2266	1133.0	53.4	26.7	T antigen is bound to a host protein in SV40-transformed cells.	D P Lane, L V Crawford	Nature	1979	218111	Yes
3948	1133	1133.0	0.0	0.0	On the prediction of occurrence of particular verbal intrusions in immediate recall.	J DEESE	J Exp Psychol	1959	13664879	Yes
3949	1133	1133.0	0.0	0.0	pA, a new scale for the measurement of drug antagonism.	H O SCHILD	Br J Pharmacol Chemother	1947	20258355	Yes
3950	2266	1133.0	71.3	35.6	Intestinal epithelial cells: regulators of barrier function and immune homeostasis.	Lance W Peterson, David Artis	Nat Rev Immunol	2014	24566914	No
3951	1133	1133.0	38.5	38.5	Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.	Gyorgy Buzsaki	Hippocampus	2015	26135716	No
3952	1132	1132.0	20.2	20.2	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
3953	2264	1132.0	99.1	49.5	Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.	J B Mulliken, J Glowacki	Plast Reconstr Surg	1982	7063565	Yes
3954	1132	1132.0	21.6	21.6	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
3955	2263	1131.5	55.8	27.9	A rating scale for extrapyramidal side effects.	G M Simpson, J W Angus	Acta Psychiatr Scand Suppl	1970	4917967	Yes
3956	4526	1131.5	120.3	30.1	A role for mitochondria in NLRP3 inflammasome activation.	Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg Tschopp	Nature	2011	21124315	Yes
3957	3394	1131.3	64.4	21.5	Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.	Paola Scaffidi, Tom Misteli, Marco E Bianchi	Nature	2002	12110890	Yes
3958	1131	1131.0	34.6	34.6	Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.	J E Oesterling	J Urol	1991	1707989	No
3959	1131	1131.0	43.0	43.0	On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture.	D Collen	Thromb Haemost	1980	6450468	No
3960	1131	1131.0	0.0	0.0	The effect of emotion on cue utilization and the organization of behavior.	J A EASTERBROOK	Psychol Rev	1959	13658305	Yes
3961	1131	1131.0	24.9	24.9	The neurobiology of consolidations, or, how stable is the engram?	Yadin Dudai	Annu Rev Psychol	2004	14744210	No
3962	1131	1131.0	30.4	30.4	Innate immunity of fish (overview).	Bergljot Magnadottir	Fish Shellfish Immunol	2006	15950491	No
3963	4524	1131.0	136.3	34.1	Causal analysis approaches in Ingenuity Pathway Analysis.	Andreas Kramer, Jeff Green, Jack Pollard, Stuart Tugendreich	Bioinformatics	2014	24336805	Yes
3964	1130	1130.0	40.0	40.0	Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases.	J N Wasserheit	Sex Transm Dis	1992	1595015	No
3965	1130	1130.0	30.3	30.3	Micellar nanocarriers: pharmaceutical perspectives.	V P Torchilin	Pharm Res	2007	17109211	No
3966	1130	1130.0	27.2	27.2	Telomere length measurement by a novel monochrome multiplex quantitative PCR method.	Richard M Cawthon	Nucleic Acids Res	2009	19129229	Yes
3967	1130	1130.0	30.1	30.1	Voltage-gated calcium channels.	William A Catterall	Cold Spring Harb Perspect Biol	2011	21746798	No
3968	2259	1129.5	45.1	22.6	RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.	M B Shapiro, P Senapathy	Nucleic Acids Res	1987	3658675	Yes
3969	2259	1129.5	46.5	23.2	An energy budget for signaling in the grey matter of the brain.	D Attwell, S B Laughlin	J Cereb Blood Flow Metab	2001	11598490	No
3970	1129	1129.0	28.4	28.4	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
3971	1129	1129.0	27.9	27.9	Sex-hormone-binding globulin.	D C Anderson	Clin Endocrinol (Oxf)	1974	4134992	No
3972	1129	1129.0	28.6	28.6	Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.	M M Weiser	J Biol Chem	1973	4698230	Yes
3973	2258	1129.0	52.4	26.2	The oxytocin receptor system: structure, function, and regulation.	G Gimpl, F Fahrenholz	Physiol Rev	2001	11274341	No
3974	2258	1129.0	53.0	26.5	The NF-kappaB family of transcription factors and its regulation.	Andrea Oeckinghaus, Sankar Ghosh	Cold Spring Harb Perspect Biol	2009	20066092	No
3975	1129	1129.0	42.6	42.6	A comprehensive review on metabolic syndrome.	Jaspinder Kaur	Cardiol Res Pract	2014	24711954	No
3976	1128	1128.0	27.3	27.3	Anti-inflammatory actions of glucocorticoids: molecular mechanisms.	P J Barnes	Clin Sci (Lond)	1998	9854452	No
3977	1128	1128.0	23.5	23.5	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
3978	1128	1128.0	24.1	24.1	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
3979	1128	1128.0	0.0	0.0	Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.	A B STAVITSKY	J Immunol	1954	13163409	Yes
3980	2256	1128.0	72.2	36.1	Required sample size to detect the mediated effect.	Matthew S Fritz, David P Mackinnon	Psychol Sci	2007	17444920	Yes
3981	4511	1127.8	85.3	21.3	DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.	M Okano, D W Bell, D A Haber, E Li	Cell	1999	10555141	Yes
3982	2255	1127.5	36.4	18.2	Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.	L M Siegel, K J Monty	Biochim Biophys Acta	1966	5329026	Yes
3983	1127	1127.0	32.9	32.9	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3984	1127	1127.0	34.1	34.1	Food reward: brain substrates of wanting and liking.	K C Berridge	Neurosci Biobehav Rev	1996	8622814	No
3985	2253	1126.5	52.9	26.4	Using RepeatMasker to identify repetitive elements in genomic sequences.	Maja Tarailo-Graovac, Nansheng Chen	Curr Protoc Bioinformatics	2009	19274634	Yes
3986	1126	1126.0	23.6	23.6	Mutator phenotype may be required for multistage carcinogenesis.	L A Loeb	Cancer Res	1991	2039987	No
3987	2252	1126.0	62.1	31.1	Flexible regression models with cubic splines.	S Durrleman, R Simon	Stat Med	1989	2657958	Yes
3988	1126	1126.0	27.8	27.8	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
3989	3377	1125.7	119.9	40.0	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3990	2251	1125.5	55.8	27.9	A general purpose model for the condensed phases of water: TIP4P/2005.	J L F Abascal, C Vega	J Chem Phys	2005	16392929	Yes
3991	1125	1125.0	49.4	49.4	Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.	S Z Langer	Br J Pharmacol	1977	20190	No
3992	1125	1125.0	39.8	39.8	Perceptual selectivity for color and form.	J Theeuwes	Percept Psychophys	1992	1620571	No
3993	1125	1125.0	35.9	35.9	Why people use health services.	I M Rosenstock	Milbank Mem Fund Q	1966	5967464	Yes
3994	1125	1125.0	36.6	36.6	Perceptual load as a necessary condition for selective attention.	N Lavie	J Exp Psychol Hum Percept Perform	1995	7790827	Yes
3995	1125	1125.0	20.4	20.4	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
3996	1125	1125.0	20.7	20.7	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
3997	1125	1125.0	31.6	31.6	Cytochrome p450 and chemical toxicology.	F Peter Guengerich	Chem Res Toxicol	2008	18052394	No
3998	1125	1125.0	47.8	47.8	Fibromyalgia: a clinical review.	Daniel J Clauw	JAMA	2014	24737367	No
3999	2249	1124.5	97.3	48.6	Severe psoriasis--oral therapy with a new retinoid.	T Fredriksson, U Pettersson	Dermatologica	1978	357213	Yes
4000	2248	1124.0	83.6	41.8	The structure of psychological well-being revisited.	C D Ryff, C L Keyes	J Pers Soc Psychol	1995	7473027	Yes
4001	1124	1124.0	26.6	26.6	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
4002	1124	1124.0	32.3	32.3	Image matching as a diffusion process: an analogy with Maxwell's demons.	J P Thirion	Med Image Anal	1998	9873902	Yes
4003	1124	1124.0	24.5	24.5	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
4004	2248	1124.0	47.0	23.5	InterProScan--an integration platform for the signature-recognition methods in InterPro.	E M Zdobnov, R Apweiler	Bioinformatics	2001	11590104	Yes
4005	1124	1124.0	25.9	25.9	The emotional brain, fear, and the amygdala.	Joseph LeDoux	Cell Mol Neurobiol	2003	14514027	No
4006	1124	1124.0	26.9	26.9	Hybridization as an invasion of the genome.	James Mallet	Trends Ecol Evol	2005	16701374	Yes
4007	1124	1124.0	23.9	23.9	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
4008	2248	1124.0	91.5	45.8	The social determinants of health: it's time to consider the causes of the causes.	Paula Braveman, Laura Gottlieb	Public Health Rep	2014	24385661	No
4009	1123	1123.0	41.4	41.4	Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.	A R Midgley	Endocrinology	1966	5950482	Yes
4010	2246	1123.0	48.7	24.4	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
4011	1123	1123.0	36.4	36.4	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
4012	1123	1123.0	21.8	21.8	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
4013	1123	1123.0	25.3	25.3	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
4014	2246	1123.0	62.2	31.1	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
4015	4489	1122.2	115.2	28.8	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
4016	1122	1122.0	55.4	55.4	The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.	J A Koufman	Laryngoscope	1991	1895864	No
4017	1122	1122.0	33.2	33.2	Cell surface interactions with extracellular materials.	K M Yamada	Annu Rev Biochem	1983	6351729	No
4018	1122	1122.0	21.3	21.3	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
4019	1122	1122.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B REXED	J Comp Neurol	1954	13163236	Yes
4020	1122	1122.0	0.0	0.0	Neural basis of the spontaneous optokinetic response produced by visual inversion.	R W SPERRY	J Comp Physiol Psychol	1950	14794830	Yes
4021	1122	1122.0	23.2	23.2	The molecular biology of coronaviruses.	Paul S Masters	Adv Virus Res	2006	16877062	No
4022	1122	1122.0	32.2	32.2	Outer membrane permeability and antibiotic resistance.	Anne H Delcour	Biochim Biophys Acta	2009	19100346	No
4023	1122	1122.0	26.3	26.3	Targeting cancer metabolism: a therapeutic window opens.	Matthew G Vander Heiden	Nat Rev Drug Discov	2011	21878982	No
4024	1122	1122.0	45.0	45.0	The epidemiology and impact of pain in osteoarthritis.	T Neogi	Osteoarthritis Cartilage	2013	23973124	Yes
4025	6729	1121.5	151.5	25.2	Alpha-synuclein in Lewy bodies.	M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert	Nature	1997	9278044	Yes
4026	2243	1121.5	65.5	32.8	Stool form scale as a useful guide to intestinal transit time.	S J Lewis, K W Heaton	Scand J Gastroenterol	1997	9299672	Yes
4027	2243	1121.5	60.8	30.4	Collagen structure and stability.	Matthew D Shoulders, Ronald T Raines	Annu Rev Biochem	2009	19344236	No
4028	1121	1121.0	29.6	29.6	The chromosomal basis of human neoplasia.	J J Yunis	Science	1983	6336310	Yes
4029	1121	1121.0	23.1	23.1	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
4030	1121	1121.0	32.7	32.7	Spontaneous dissection of the carotid and vertebral arteries.	W I Schievink	N Engl J Med	2001	11259724	No
4031	4482	1120.5	110.5	27.6	Wound repair and regeneration.	Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T Longaker	Nature	2008	18480812	No
4032	4482	1120.5	114.0	28.5	REVIGO summarizes and visualizes long lists of gene ontology terms.	Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav Smuc	PLoS One	2011	21789182	Yes
4033	1120	1120.0	18.5	18.5	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
4034	2240	1120.0	52.5	26.2	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral,	Lancet	2003	12927427	Yes
4035	1120	1120.0	27.7	27.7	Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases.	Jill E Clarridge	Clin Microbiol Rev	2004	15489351	No
4036	1120	1120.0	43.9	43.9	Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance.	Philip C Calder	Biochim Biophys Acta	2015	25149823	No
4037	2239	1119.5	66.0	33.0	A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250.	J J Sedmak, S E Grossberg	Anal Biochem	1977	68686	Yes
4038	3358	1119.3	92.7	30.9	Foreign body reaction to biomaterials.	James M Anderson, Analiz Rodriguez, David T Chang	Semin Immunol	2008	18162407	No
4039	2238	1119.0	53.5	26.8	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
4040	1119	1119.0	23.2	23.2	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
4041	2238	1119.0	53.3	26.6	Inflammatory bowel disease.	Clara Abraham, Judy H Cho	N Engl J Med	2009	19923578	No
4042	2237	1118.5	56.8	28.4	Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.	L Pellerin, P J Magistretti	Proc Natl Acad Sci U S A	1994	7938003	Yes
4043	2237	1118.5	59.1	29.6	The cerebellar cognitive affective syndrome.	J D Schmahmann, J C Sherman	Brain	1998	9577385	Yes
4044	2237	1118.5	26.5	13.2	Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques.	P GOLD, S O FREEDMAN	J Exp Med	1965	14270243	Yes
4045	3355	1118.3	140.8	46.9	Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.	Neil M Davies, Michael V Holmes, George Davey Smith	BMJ	2018	30002074	Yes
4046	3354	1118.0	134.5	44.8	A new method for detecting anaerobic threshold by gas exchange.	W L Beaver, K Wasserman, B J Whipp	J Appl Physiol (1985)	1986	3087938	Yes
4047	1118	1118.0	30.6	30.6	Transport of molecules in the tumor interstitium: a review.	R K Jain	Cancer Res	1987	3555767	No
4048	1118	1118.0	37.1	37.1	Chemoprevention of cancer.	L W Wattenberg	Cancer Res	1985	3880665	No
4049	1118	1118.0	27.1	27.1	Biological effects of resveratrol.	L Fremont	Life Sci	2000	10680575	No
4050	1118	1118.0	0.0	0.0	Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins.	R D Owen	Science	1945	17755278	Yes
4051	1117	1117.0	61.9	61.9	The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture.	J Cassel	Am J Epidemiol	1976	782233	No
4052	2234	1117.0	108.7	54.4	Optimism, coping, and health: assessment and implications of generalized outcome expectancies.	M F Scheier, C S Carver	Health Psychol	1985	4029106	Yes
4053	1117	1117.0	22.5	22.5	The muscular dystrophies.	Alan E H Emery	Lancet	2002	11879882	No
4054	2234	1117.0	32.2	16.1	Microdroplet Assay Of Human Serum Cytotoxins.	P I TERASAKI, J D MCCLELLAND	Nature	1964	14248725	Yes
4055	1117	1117.0	22.8	22.8	Large-scale recording of neuronal ensembles.	Gyorgy Buzsaki	Nat Neurosci	2004	15114356	No
4056	1117	1117.0	55.6	55.6	COVID-19: immunopathology and its implications for therapy.	Xuetao Cao	Nat Rev Immunol	2020	32273594	Yes
4057	4465	1116.2	139.6	34.9	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
4058	1116	1116.0	13.3	13.3	Studies on histones. 7. Preparative methods for histone fractions from calf thymus.	E W Johns	Biochem J	1964	5840387	Yes
4059	2231	1115.5	93.8	46.9	Biological Functions of Autophagy Genes: A Disease Perspective.	Beth Levine, Guido Kroemer	Cell	2019	30633901	No
4060	3346	1115.3	109.9	36.6	A new rating scale for Alzheimer's disease.	W G Rosen, R C Mohs, K L Davis	Am J Psychiatry	1984	6496779	Yes
4061	3346	1115.3	100.3	33.4	DNA methylation and its basic function.	Lisa D Moore, Thuc Le, Guoping Fan	Neuropsychopharmacology	2013	22781841	No
4062	1115	1115.0	45.7	45.7	Movement, posture and equilibrium: interaction and coordination.	J Massion	Prog Neurobiol	1992	1736324	No
4063	1115	1115.0	36.8	36.8	Lipid peroxidation and antioxidants as biomarkers of tissue damage.	J M Gutteridge	Clin Chem	1995	7497639	No
4064	1115	1115.0	29.6	29.6	Inhibition of return.	R M Klein	Trends Cogn Sci	2000	10740278	Yes
4065	2230	1115.0	54.7	27.4	Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.	D Rice, S Barone	Environ Health Perspect	2000	10852851	No
4066	2230	1115.0	49.2	24.6	How to interpret LC3 immunoblotting.	Noboru Mizushima, Tamotsu Yoshimori	Autophagy	2007	17611390	No
4067	1115	1115.0	34.9	34.9	Vitamin D status: measurement, interpretation, and clinical application.	Michael F Holick	Ann Epidemiol	2009	18329892	No
4068	1115	1115.0	23.3	23.3	The self-tuning neuron: synaptic scaling of excitatory synapses.	Gina G Turrigiano	Cell	2008	18984155	No
4069	2229	1114.5	46.4	23.2	Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.	P J Roberts, C J Der	Oncogene	2007	17496923	No
4070	2228	1114.0	69.5	34.8	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
4071	1114	1114.0	31.7	31.7	Microbial heavy-metal resistance.	D H Nies	Appl Microbiol Biotechnol	1999	10422221	No
4072	1114	1114.0	20.5	20.5	Cytokines in cancer pathogenesis and cancer therapy.	Glenn Dranoff	Nat Rev Cancer	2004	14708024	No
4073	1114	1114.0	21.6	21.6	Automated NMR structure calculation with CYANA.	Peter Guntert	Methods Mol Biol	2004	15318003	Yes
4074	1114	1114.0	26.9	26.9	Sleep-dependent memory consolidation.	Robert Stickgold	Nature	2005	16251952	No
4075	1114	1114.0	20.5	20.5	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
4076	1114	1114.0	21.0	21.0	The evolutionary significance of cis-regulatory mutations.	Gregory A Wray	Nat Rev Genet	2007	17304246	No
4077	2228	1114.0	45.2	22.6	GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor.	Sean Davis, Paul S Meltzer	Bioinformatics	2007	17496320	Yes
4078	2228	1114.0	58.4	29.2	DNA methylation: roles in mammalian development.	Zachary D Smith, Alexander Meissner	Nat Rev Genet	2013	23400093	No
4079	2227	1113.5	53.7	26.9	The regulation and function of c-fos and other immediate early genes in the nervous system.	M Sheng, M E Greenberg	Neuron	1990	1969743	No
4080	11133	1113.3	389.9	39.0	The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.	Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher	PLoS Med	2009	19621070	No
4081	1113	1113.0	28.1	28.1	Two distinct classes of carbohydrate-recognition domains in animal lectins.	K Drickamer	J Biol Chem	1988	3290208	No
4082	1113	1113.0	22.5	22.5	mRNA stability in mammalian cells.	J Ross	Microbiol Rev	1995	7565413	No
4083	1113	1113.0	24.0	24.0	A cortical-hippocampal system for declarative memory.	H Eichenbaum	Nat Rev Neurosci	2000	11252767	No
4084	2225	1112.5	77.4	38.7	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
4085	2225	1112.5	53.7	26.9	Recent developments in the MAFFT multiple sequence alignment program.	Kazutaka Katoh, Hiroyuki Toh	Brief Bioinform	2008	18372315	Yes
4086	1112	1112.0	13.9	13.9	The evolutionary advantage of recombination.	J Felsenstein	Genetics	1974	4448362	Yes
4087	1112	1112.0	28.1	28.1	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
4088	1112	1112.0	37.1	37.1	The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.	James A Imlay	Nat Rev Microbiol	2013	23712352	No
4089	2224	1112.0	85.3	42.6	Mechanism and medical implications of mammalian autophagy.	Ivan Dikic, Zvulun Elazar	Nat Rev Mol Cell Biol	2018	29618831	No
4090	14450	1111.5	377.7	29.1	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, ,	JAMA	2003	12748199	No
4091	4446	1111.5	120.4	30.1	voom: Precision weights unlock linear model analysis tools for RNA-seq read counts.	Charity W Law, Yunshun Chen, Wei Shi, Gordon K Smyth	Genome Biol	2014	24485249	Yes
4092	1111	1111.0	51.0	51.0	Psychophysical scaling with applications in physical work and the perception of exertion.	G Borg	Scand J Work Environ Health	1990	2345867	Yes
4093	1111	1111.0	41.6	41.6	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
4094	1111	1111.0	32.6	32.6	The Delphi technique: myths and realities.	Catherine Powell	J Adv Nurs	2003	12581103	No
4095	1111	1111.0	27.9	27.9	Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses.	Paul H Yancey	J Exp Biol	2005	16043587	No
4096	1111	1111.0	47.5	47.5	Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review.	Franziska Reiss	Soc Sci Med	2013	23746605	Yes
4097	1110	1110.0	37.9	37.9	A theory of visual attention.	C Bundesen	Psychol Rev	1990	2247540	Yes
4098	1110	1110.0	23.2	23.2	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
4099	1110	1110.0	21.6	21.6	Unfolding the role of protein misfolding in neurodegenerative diseases.	Claudio Soto	Nat Rev Neurosci	2003	12511861	No
4100	1110	1110.0	41.6	41.6	Cancer-related fatigue--mechanisms, risk factors, and treatments.	Julienne E Bower	Nat Rev Clin Oncol	2014	25113839	No
4101	2220	1110.0	79.9	40.0	Mechanisms of hepatic stellate cell activation.	Takuma Tsuchida, Scott L Friedman	Nat Rev Gastroenterol Hepatol	2017	28487545	No
4102	4439	1109.8	149.5	37.4	Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.	S Pellow, P Chopin, S E File, M Briley	J Neurosci Methods	1985	2864480	Yes
4103	9987	1109.7	305.9	34.0	Robust enumeration of cell subsets from tissue expression profiles.	Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A Alizadeh	Nat Methods	2015	25822800	Yes
4104	2219	1109.5	68.4	34.2	Shaping functional architecture by oscillatory alpha activity: gating by inhibition.	Ole Jensen, Ali Mazaheri	Front Hum Neurosci	2010	21119777	Yes
4105	2219	1109.5	52.2	26.1	CpG islands and the regulation of transcription.	Aimee M Deaton, Adrian Bird	Genes Dev	2011	21576262	No
4106	4437	1109.2	102.1	25.5	The epidemiology of sepsis in the United States from 1979 through 2000.	Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss	N Engl J Med	2003	12700374	Yes
4107	4437	1109.2	108.0	27.0	An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.	Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette	Neuroimage	2003	12880848	Yes
4108	1109	1109.0	22.3	22.3	Primary response genes induced by growth factors and tumor promoters.	H R Herschman	Annu Rev Biochem	1991	1883198	No
4109	1109	1109.0	25.7	25.7	Selectins and their ligands: current concepts and controversies.	G S Kansas	Blood	1996	8896391	No
4110	1109	1109.0	27.3	27.3	Forests and climate change: forcings, feedbacks, and the climate benefits of forests.	Gordon B Bonan	Science	2008	18556546	No
4111	2218	1109.0	49.1	24.6	Mechanisms of endocytosis.	Gary J Doherty, Harvey T McMahon	Annu Rev Biochem	2009	19317650	No
4112	2217	1108.5	45.6	22.8	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
4113	7759	1108.4	654.5	93.5	The psychological impact of quarantine and how to reduce it: rapid review of the evidence.	Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin	Lancet	2020	32112714	No
4114	3325	1108.3	108.4	36.1	Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.	M Hamberg, J Svensson, B Samuelsson	Proc Natl Acad Sci U S A	1975	1059088	Yes
4115	1108	1108.0	32.5	32.5	Comparing evolvability and variability of quantitative traits.	D Houle	Genetics	1992	1732160	Yes
4116	1108	1108.0	25.9	25.9	A kinetic photometric method for serum gamma-glutamyl transpeptidase.	G Szasz	Clin Chem	1969	5773262	Yes
4117	2216	1108.0	47.5	23.8	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
4118	1108	1108.0	0.0	0.0	Asymptomatic infections of the urinary tract.	E H KASS	Trans Assoc Am Physicians	1956	13380946	Yes
4119	2216	1108.0	59.9	29.9	The spread of obesity in a large social network over 32 years.	Nicholas A Christakis, James H Fowler	N Engl J Med	2007	17652652	Yes
4120	1108	1108.0	35.0	35.0	Designing cell-compatible hydrogels for biomedical applications.	Dror Seliktar	Science	2012	22654050	No
4121	4429	1107.2	113.1	28.3	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
4122	4428	1107.0	158.8	39.7	Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.	K F Schulz, I Chalmers, R J Hayes, D G Altman	JAMA	1995	7823387	Yes
4123	1107	1107.0	0.0	0.0	Cleavage of the haem-protein link by acid methylethylketone.	F W TEALE	Biochim Biophys Acta	1959	13837237	Yes
4124	2214	1107.0	64.9	32.5	Exploring the brain network: a review on resting-state fMRI functional connectivity.	Martijn P van den Heuvel, Hilleke E Hulshoff Pol	Eur Neuropsychopharmacol	2010	20471808	No
4125	2214	1107.0	87.1	43.5	Global estimates of visual impairment: 2010.	Donatella Pascolini, Silvio Paolo Mariotti	Br J Ophthalmol	2012	22133988	Yes
4126	1107	1107.0	33.6	33.6	Molecular pathogenesis and mechanisms of thyroid cancer.	Mingzhao Xing	Nat Rev Cancer	2013	23429735	No
4127	6640	1106.7	164.7	27.4	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
4128	2213	1106.5	64.9	32.5	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
4129	2213	1106.5	66.0	33.0	The human microbiome: at the interface of health and disease.	Ilseung Cho, Martin J Blaser	Nat Rev Genet	2012	22411464	No
4130	2212	1106.0	72.0	36.0	Population growth makes waves in the distribution of pairwise genetic differences.	A R Rogers, H Harpending	Mol Biol Evol	1992	1316531	Yes
4131	2212	1106.0	0.0	0.0	Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.	A H COONS, M H KAPLAN	J Exp Med	1950	15395569	Yes
4132	2212	1106.0	76.6	38.3	Coronaviruses: an overview of their replication and pathogenesis.	Anthony R Fehr, Stanley Perlman	Methods Mol Biol	2015	25720466	No
4133	2211	1105.5	89.9	45.0	Emotional processing of fear: exposure to corrective information.	E B Foa, M J Kozak	Psychol Bull	1986	2871574	Yes
4134	2211	1105.5	38.3	19.1	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
4135	5527	1105.4	115.3	23.1	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.	J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge	Cell	1993	8242751	Yes
4136	1105	1105.0	29.8	29.8	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
4137	2210	1105.0	48.7	24.4	Cell cycle control and cancer.	L H Hartwell, M B Kastan	Science	1994	7997877	No
4138	1105	1105.0	23.0	23.0	Ligand-targeted therapeutics in anticancer therapy.	Theresa M Allen	Nat Rev Cancer	2002	12360278	No
4139	1105	1105.0	23.0	23.0	Evolution of the neocortex: a perspective from developmental biology.	Pasko Rakic	Nat Rev Neurosci	2009	19763105	No
4140	2209	1104.5	65.7	32.9	2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.	A Poland, J C Knutson	Annu Rev Pharmacol Toxicol	1982	6282188	No
4141	2208	1104.0	43.9	21.9	In search of the 'missing self': MHC molecules and NK cell recognition.	H G Ljunggren, K Karre	Immunol Today	1990	2201309	No
4142	1104	1104.0	18.3	18.3	The concept of synthetic lethality in the context of anticancer therapy.	William G Kaelin	Nat Rev Cancer	2005	16110319	No
4143	1104	1104.0	44.7	44.7	The theory of planned behaviour: reactions and reflections.	Icek Ajzen	Psychol Health	2011	21929476	No
4144	1103	1103.0	21.7	21.7	Coiled coils: new structures and new functions.	A Lupas	Trends Biochem Sci	1996	8918191	No
4145	2206	1103.0	54.0	27.0	Adjusting for multiple testing--when and how?	R Bender, S Lange	J Clin Epidemiol	2001	11297884	No
4146	2206	1103.0	47.6	23.8	p21 in cancer: intricate networks and multiple activities.	Tarek Abbas, Anindya Dutta	Nat Rev Cancer	2009	19440234	No
4147	1103	1103.0	35.3	35.3	Targeting metastasis.	Patricia S Steeg	Nat Rev Cancer	2016	27009393	No
4148	2205	1102.5	103.5	51.8	Development, reliability, and validity of a dissociation scale.	E M Bernstein, F W Putnam	J Nerv Ment Dis	1986	3783140	Yes
4149	2205	1102.5	56.1	28.1	How should meta-regression analyses be undertaken and interpreted?	Simon G Thompson, Julian P T Higgins	Stat Med	2002	12111920	Yes
4150	2205	1102.5	46.6	23.3	Glycosylation in cellular mechanisms of health and disease.	Kazuaki Ohtsubo, Jamey D Marth	Cell	2006	16959566	No
4151	2205	1102.5	52.3	26.1	Clonal evolution in cancer.	Mel Greaves, Carlo C Maley	Nature	2012	22258609	No
4152	2205	1102.5	94.8	47.4	Introduction to the human gut microbiota.	Elizabeth Thursby, Nathalie Juge	Biochem J	2017	28512250	No
4153	1102	1102.0	18.9	18.9	Protein denaturation. C. Theoretical models for the mechanism of denaturation.	C Tanford	Adv Protein Chem	1970	4912353	No
4154	1102	1102.0	22.1	22.1	Time-dependent processes in memory storage.	J L McGaugh	Science	1966	5917768	Yes
4155	2204	1102.0	45.2	22.6	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
4156	1102	1102.0	25.0	25.0	Marine viruses and their biogeochemical and ecological effects.	J A Fuhrman	Nature	1999	10376593	No
4157	3306	1102.0	79.9	26.6	Stress and the brain: from adaptation to disease.	E Ron de Kloet, Marian Joels, Florian Holsboer	Nat Rev Neurosci	2005	15891777	No
4158	2203	1101.5	61.5	30.8	Systematic optimization of long-range corrected hybrid density functionals.	Jeng-Da Chai, Martin Head-Gordon	J Chem Phys	2008	18315032	Yes
4159	2203	1101.5	69.6	34.8	The economy of brain network organization.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2012	22498897	No
4160	1101	1101.0	41.9	41.9	The role of endothelium in the responses of vascular smooth muscle to drugs.	R F Furchgott	Annu Rev Pharmacol Toxicol	1984	6203480	No
4161	1101	1101.0	21.5	21.5	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
4162	1101	1101.0	33.8	33.8	The oxidation hypothesis of atherosclerosis.	J L Witztum	Lancet	1994	7916078	No
4163	1101	1101.0	24.7	24.7	The primate basal ganglia: parallel and integrative networks.	Suzanne N Haber	J Chem Neuroanat	2003	14729134	No
4164	1101	1101.0	29.2	29.2	Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.	John W Newcomer	CNS Drugs	2005	15998156	No
4165	2202	1101.0	57.3	28.6	The use of the elevated plus maze as an assay of anxiety-related behavior in rodents.	Alicia A Walf, Cheryl A Frye	Nat Protoc	2007	17406592	Yes
4166	1101	1101.0	26.0	26.0	Trypan blue exclusion test of cell viability.	W Strober	Curr Protoc Immunol	2001	18432654	Yes
4167	1101	1101.0	34.5	34.5	Isolation By Distance In Equilibrium And Non-Equilibrium Populations.	Montgomery Slatkin	Evolution	1993	28568097	Yes
4168	2201	1100.5	64.4	32.2	Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.	C N Hales, D J Barker	Diabetologia	1992	1644236	No
4169	2201	1100.5	49.3	24.6	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
4170	1100	1100.0	32.6	32.6	Topography of cognition: parallel distributed networks in primate association cortex.	P S Goldman-Rakic	Annu Rev Neurosci	1988	3284439	No
4171	1100	1100.0	25.2	25.2	Biochemistry and genetics of von Willebrand factor.	J E Sadler	Annu Rev Biochem	1998	9759493	No
4172	1100	1100.0	30.7	30.7	Lanthanide-based luminescent hybrid materials.	Koen Binnemans	Chem Rev	2009	19650663	Yes
4173	1100	1100.0	36.0	36.0	Chemistry and biochemistry of dietary polyphenols.	Rong Tsao	Nutrients	2010	22254006	No
4174	1100	1100.0	34.7	34.7	Measures of Diagnostic Accuracy: Basic Definitions.	Ana-Maria Simundic	EJIFCC	2009	27683318	Yes
4175	2199	1099.5	84.1	42.0	Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes.	N L Glass, G C Donaldson	Appl Environ Microbiol	1995	7747954	Yes
4176	2199	1099.5	0.0	0.0	Micromethod for the direct determination of serum triglycerides.	E VAN HANDEL, D B ZILVERSMIT	J Lab Clin Med	1957	13439279	Yes
4177	1099	1099.0	20.6	20.6	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
4178	1099	1099.0	29.6	29.6	Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.	R Bonnet	Antimicrob Agents Chemother	2004	14693512	No
4179	2198	1099.0	49.2	24.6	Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.	Turk Rhen, John A Cidlowski	N Engl J Med	2005	16236742	No
4180	1099	1099.0	26.0	26.0	Papillomaviruses in the causation of human cancers - a brief historical account.	Harald zur Hausen	Virology	2009	19135222	No
4181	2197	1098.5	42.0	21.0	Phosphoinositides in cell regulation and membrane dynamics.	Gilbert Di Paolo, Pietro De Camilli	Nature	2006	17035995	No
4182	1098	1098.0	18.9	18.9	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
4183	1098	1098.0	23.4	23.4	Cells of origin in cancer.	Jane E Visvader	Nature	2011	21248838	No
4184	1098	1098.0	32.0	32.0	α-Synuclein in Parkinson's disease.	Leonidas Stefanis	Cold Spring Harb Perspect Med	2012	22355802	No
4185	2196	1098.0	71.3	35.6	Microbial interactions: from networks to models.	Karoline Faust, Jeroen Raes	Nat Rev Microbiol	2012	22796884	No
4186	2196	1098.0	72.4	36.2	Fundamentals of cancer metabolism.	Ralph J DeBerardinis, Navdeep S Chandel	Sci Adv	2016	27386546	No
4187	14268	1097.5	828.8	63.8	SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.	Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Kruger, Tanja Herrler, Sandra Erichsen, Tobias S Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche, Marcel A Muller, Christian Drosten, Stefan Pohlmann	Cell	2020	32142651	Yes
4188	1097	1097.0	26.8	26.8	Avidin.	N M Green	Adv Protein Chem	1975	237414	Yes
4189	1097	1097.0	20.6	20.6	Luciferase reporter gene vectors for analysis of promoters and enhancers.	S K Nordeen	Biotechniques	1988	2908509	Yes
4190	1097	1097.0	20.5	20.5	The immune response of Drosophila.	Jules A Hoffmann	Nature	2003	14603309	No
4191	1097	1097.0	23.8	23.8	Immunosuppressive drugs for kidney transplantation.	Philip F Halloran	N Engl J Med	2004	15616206	No

_{Unicorn Papers}

Top ‱ cited papers from PUBMED

Volume 68, April 2026