Unicorn Papers
, literally meaning "for (every) myriad (ten thousand)"
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 226310 | 226310.0 | 4717.2 | 4717.2 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 182366 | 182366.0 | 7200.6 | 7200.6 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 288266 | 72066.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 139224 | 69612.0 | 3388.2 | 1694.1 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 46751 | 46751.0 | 1369.1 | 1369.1 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 38865 | 38865.0 | 1247.4 | 1247.4 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64769 | 32384.5 | 1931.2 | 965.6 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30268 | 30268.0 | 809.8 | 809.8 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 29875 | 29875.0 | 688.4 | 688.4 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 10 | 29592 | 29592.0 | 929.0 | 929.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 29129 | 29129.0 | 625.3 | 625.3 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 12 | 27703 | 27703.0 | 702.8 | 702.8 | A rating scale for depression. | M HAMILTON | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 26555 | 26555.0 | 597.8 | 597.8 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 25727 | 25727.0 | 801.3 | 801.3 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 48087 | 24043.5 | 1402.4 | 701.2 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 16 | 23656 | 23656.0 | 635.1 | 635.1 | Projector augmented-wave method. | P E Blochl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 17 | 70179 | 23393.0 | 2506.9 | 835.6 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 18 | 66443 | 22147.7 | 1632.5 | 544.2 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 19 | 22010 | 22010.0 | 742.9 | 742.9 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 63624 | 21208.0 | 2181.9 | 727.3 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 21 | 42017 | 21008.5 | 1294.6 | 647.3 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 22 | 20557 | 20557.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 23 | 20485 | 20485.0 | 203.9 | 203.9 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J Cell Biol | 1963 | 13986422 | Yes |
| 24 | 19964 | 19964.0 | 770.8 | 770.8 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 25 | 39912 | 19956.0 | 1610.9 | 805.5 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 26 | 38785 | 19392.5 | 1150.1 | 575.0 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 27 | 57429 | 19143.0 | 1645.6 | 548.5 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 28 | 38044 | 19022.0 | 1763.6 | 881.8 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 29 | 18520 | 18520.0 | 679.2 | 679.2 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 30 | 18420 | 18420.0 | 750.4 | 750.4 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 31 | 36031 | 18015.5 | 870.7 | 435.4 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 32 | 53672 | 17890.7 | 2029.8 | 676.6 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 33 | 17370 | 17370.0 | 427.5 | 427.5 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 34 | 17226 | 17226.0 | 773.0 | 773.0 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 35 | 33618 | 16809.0 | 1320.3 | 660.1 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 36 | 16775 | 16775.0 | 283.0 | 283.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J DAVIS | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 37 | 33473 | 16736.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 38 | 16251 | 16251.0 | 620.6 | 620.6 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 39 | 16237 | 16237.0 | 388.5 | 388.5 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 40 | 16227 | 16227.0 | 442.5 | 442.5 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 41 | 32260 | 16130.0 | 1194.3 | 597.1 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 42 | 32198 | 16099.0 | 854.3 | 427.1 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmuller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 43 | 15939 | 15939.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem J | 1956 | 13293190 | Yes |
| 44 | 46528 | 15509.3 | 1317.2 | 439.1 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 45 | 14544 | 14544.0 | 540.7 | 540.7 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 46 | 43596 | 14532.0 | 1553.8 | 517.9 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 47 | 43267 | 14422.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J Biol Chem | 1957 | 13428781 | Yes |
| 48 | 14041 | 14041.0 | 338.4 | 338.4 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 49 | 13854 | 13854.0 | 456.8 | 456.8 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 50 | 27555 | 13777.5 | 729.8 | 364.9 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 51 | 27513 | 13756.5 | 549.3 | 274.6 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 52 | 27448 | 13724.0 | 973.5 | 486.8 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 53 | 68420 | 13684.0 | 1950.4 | 390.1 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 54 | 13563 | 13563.0 | 609.1 | 609.1 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 55 | 13497 | 13497.0 | 406.2 | 406.2 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 56 | 13311 | 13311.0 | 396.7 | 396.7 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 57 | 39716 | 13238.7 | 1371.2 | 457.1 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 58 | 26448 | 13224.0 | 1063.1 | 531.5 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 59 | 26261 | 13130.5 | 555.1 | 277.6 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 60 | 12983 | 12983.0 | 150.3 | 150.3 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 61 | 12930 | 12930.0 | 530.3 | 530.3 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 62 | 38489 | 12829.7 | 989.7 | 329.9 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 63 | 12661 | 12661.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J Biol Chem | 1959 | 13641241 | Yes |
| 64 | 12609 | 12609.0 | 410.7 | 410.7 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 65 | 37801 | 12600.3 | 1191.4 | 397.1 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 66 | 12217 | 12217.0 | 456.5 | 456.5 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 67 | 23931 | 11965.5 | 512.2 | 256.1 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 68 | 47332 | 11833.0 | 1317.8 | 329.4 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 69 | 11658 | 11658.0 | 512.5 | 512.5 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 70 | 22306 | 11153.0 | 926.2 | 463.1 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 71 | 11148 | 11148.0 | 279.7 | 279.7 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 72 | 10875 | 10875.0 | 352.3 | 352.3 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 73 | 10817 | 10817.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 74 | 21563 | 10781.5 | 555.5 | 277.8 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 75 | 10524 | 10524.0 | 441.8 | 441.8 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 76 | 10506 | 10506.0 | 283.8 | 283.8 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 77 | 41315 | 10328.8 | 1491.5 | 372.9 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 78 | 10313 | 10313.0 | 196.4 | 196.4 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 79 | 10299 | 10299.0 | 291.0 | 291.0 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 80 | 30861 | 10287.0 | 881.9 | 294.0 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 81 | 40983 | 10245.8 | 1306.1 | 326.5 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 82 | 20440 | 10220.0 | 596.0 | 298.0 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 83 | 10119 | 10119.0 | 203.8 | 203.8 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 84 | 30325 | 10108.3 | 764.4 | 254.8 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 85 | 9992 | 9992.0 | 232.9 | 232.9 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 86 | 19917 | 9958.5 | 504.2 | 252.1 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 87 | 19821 | 9910.5 | 356.5 | 178.2 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 88 | 9872 | 9872.0 | 253.1 | 253.1 | Canonical dynamics: Equilibrium phase-space distributions. | WG Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 89 | 9871 | 9871.0 | 272.5 | 272.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 90 | 9856 | 9856.0 | 382.1 | 382.1 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 91 | 19528 | 9764.0 | 500.1 | 250.1 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 92 | 9657 | 9657.0 | 316.7 | 316.7 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 93 | 9655 | 9655.0 | 242.5 | 242.5 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 94 | 19256 | 9628.0 | 392.6 | 196.3 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 95 | 19155 | 9577.5 | 434.4 | 217.2 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 96 | 28666 | 9555.3 | 698.8 | 232.9 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 97 | 9533 | 9533.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 98 | 9530 | 9530.0 | 251.2 | 251.2 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 99 | 9515 | 9515.0 | 240.1 | 240.1 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 100 | 18626 | 9313.0 | 393.4 | 196.7 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 101 | 9296 | 9296.0 | 237.6 | 237.6 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 102 | 9254 | 9254.0 | 261.0 | 261.0 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 103 | 9216 | 9216.0 | 257.4 | 257.4 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 104 | 27588 | 9196.0 | 1337.7 | 445.9 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 105 | 45911 | 9182.2 | 1689.0 | 337.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | PLoS Med | 2009 | 19621072 | No |
| 106 | 36447 | 9111.8 | 1160.7 | 290.2 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 107 | 9095 | 9095.0 | 231.6 | 231.6 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 108 | 18150 | 9075.0 | 590.5 | 295.2 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 109 | 9039 | 9039.0 | 177.1 | 177.1 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 110 | 18029 | 9014.5 | 412.2 | 206.1 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 111 | 9013 | 9013.0 | 261.7 | 261.7 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 112 | 8993 | 8993.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M HAMILTON | Br J Med Psychol | 1959 | 13638508 | Yes |
| 113 | 8979 | 8979.0 | 363.2 | 363.2 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 114 | 8883 | 8883.0 | 183.3 | 183.3 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 115 | 17595 | 8797.5 | 1040.4 | 520.2 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 116 | 26001 | 8667.0 | 764.9 | 255.0 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 117 | 8665 | 8665.0 | 393.3 | 393.3 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 118 | 25755 | 8585.0 | 872.4 | 290.8 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 119 | 16961 | 8480.5 | 376.9 | 188.4 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 120 | 8334 | 8334.0 | 225.4 | 225.4 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 121 | 8272 | 8272.0 | 343.0 | 343.0 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 122 | 8182 | 8182.0 | 197.2 | 197.2 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 123 | 16328 | 8164.0 | 390.4 | 195.2 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 124 | 8148 | 8148.0 | 195.7 | 195.7 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 125 | 8078 | 8078.0 | 250.0 | 250.0 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 126 | 8016 | 8016.0 | 155.3 | 155.3 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 127 | 8012 | 8012.0 | 164.7 | 164.7 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 128 | 8006 | 8006.0 | 275.4 | 275.4 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 129 | 7936 | 7936.0 | 218.1 | 218.1 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 130 | 7906 | 7906.0 | 256.2 | 256.2 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 131 | 15811 | 7905.5 | 430.4 | 215.2 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 132 | 7885 | 7885.0 | 225.7 | 225.7 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 133 | 7807 | 7807.0 | 214.6 | 214.6 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 134 | 23405 | 7801.7 | 904.0 | 301.3 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 135 | 7792 | 7792.0 | 231.7 | 231.7 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 136 | 7759 | 7759.0 | 249.3 | 249.3 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 137 | 7738 | 7738.0 | 221.8 | 221.8 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 138 | 7724 | 7724.0 | 218.6 | 218.6 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 139 | 15429 | 7714.5 | 405.0 | 202.5 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 140 | 7693 | 7693.0 | 195.7 | 195.7 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 141 | 53375 | 7625.0 | 1354.2 | 193.5 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 142 | 15214 | 7607.0 | 386.5 | 193.2 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 143 | 7408 | 7408.0 | 119.0 | 119.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 144 | 14487 | 7243.5 | 484.2 | 242.1 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 145 | 7190 | 7190.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J YOUDEN | Cancer | 1950 | 15405679 | Yes |
| 146 | 14254 | 7127.0 | 777.1 | 388.6 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 147 | 7090 | 7090.0 | 191.0 | 191.0 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 148 | 14027 | 7013.5 | 349.1 | 174.6 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Kohler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 149 | 6960 | 6960.0 | 115.5 | 115.5 | A Self-Rating Depression Scale. | W W ZUNG | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 150 | 6877 | 6877.0 | 203.6 | 203.6 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 151 | 6869 | 6869.0 | 183.1 | 183.1 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 152 | 6850 | 6850.0 | 132.4 | 132.4 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 153 | 6836 | 6836.0 | 155.0 | 155.0 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 154 | 6742 | 6742.0 | 217.3 | 217.3 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 155 | 6728 | 6728.0 | 153.5 | 153.5 | Inflammation, atherosclerosis, and coronary artery disease. | Goran K Hansson | N Engl J Med | 2005 | 15843671 | No |
| 156 | 6714 | 6714.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L WARREN | J Biol Chem | 1959 | 13672998 | Yes |
| 157 | 13423 | 6711.5 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N MANTEL, W HAENSZEL | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 158 | 13357 | 6678.5 | 303.2 | 151.6 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 159 | 13334 | 6667.0 | 447.6 | 223.8 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 160 | 6661 | 6661.0 | 154.9 | 154.9 | Inflammation and metabolic disorders. | Gokhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 161 | 6613 | 6613.0 | 168.9 | 168.9 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 162 | 19813 | 6604.3 | 552.5 | 184.2 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 163 | 6579 | 6579.0 | 169.7 | 169.7 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 164 | 19716 | 6572.0 | 981.1 | 327.0 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 165 | 39364 | 6560.7 | 1315.6 | 219.3 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 166 | 6543 | 6543.0 | 223.4 | 223.4 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 167 | 6521 | 6521.0 | 149.6 | 149.6 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 168 | 13014 | 6507.0 | 516.2 | 258.1 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 169 | 6486 | 6486.0 | 278.7 | 278.7 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 170 | 6475 | 6475.0 | 148.0 | 148.0 | Free radicals in the physiological control of cell function. | Wulf Droge | Physiol Rev | 2002 | 11773609 | No |
| 171 | 6459 | 6459.0 | 137.3 | 137.3 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 172 | 6456 | 6456.0 | 135.3 | 135.3 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 173 | 6423 | 6423.0 | 129.0 | 129.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 174 | 6412 | 6412.0 | 116.9 | 116.9 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 175 | 6340 | 6340.0 | 170.9 | 170.9 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 176 | 12646 | 6323.0 | 339.4 | 169.7 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
| 177 | 6321 | 6321.0 | 202.5 | 202.5 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 178 | 6306 | 6306.0 | 140.5 | 140.5 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 179 | 6249 | 6249.0 | 140.5 | 140.5 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 180 | 12433 | 6216.5 | 263.9 | 131.9 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 181 | 6206 | 6206.0 | 134.0 | 134.0 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 182 | 12410 | 6205.0 | 282.1 | 141.1 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 183 | 6195 | 6195.0 | 78.1 | 78.1 | The Environment And Disease: Association Or Causation? | A B HILL | Proc R Soc Med | 1965 | 14283879 | Yes |
| 184 | 12386 | 6193.0 | 296.4 | 148.2 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 185 | 6163 | 6163.0 | 570.0 | 570.0 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | No |
| 186 | 24594 | 6148.5 | 697.1 | 174.3 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 187 | 12284 | 6142.0 | 445.0 | 222.5 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 188 | 12283 | 6141.5 | 466.5 | 233.2 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 189 | 6127 | 6127.0 | 185.4 | 185.4 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 190 | 6093 | 6093.0 | 152.6 | 152.6 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
| 191 | 6089 | 6089.0 | 146.6 | 146.6 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 192 | 6063 | 6063.0 | 151.2 | 151.2 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 193 | 18135 | 6045.0 | 551.9 | 184.0 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 194 | 23973 | 5993.2 | 789.2 | 197.3 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 195 | 5987 | 5987.0 | 154.4 | 154.4 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
| 196 | 11938 | 5969.0 | 392.2 | 196.1 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 197 | 23712 | 5928.0 | 697.0 | 174.2 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 198 | 23702 | 5925.5 | 571.0 | 142.8 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 199 | 11839 | 5919.5 | 248.2 | 124.1 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jurgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 200 | 5907 | 5907.0 | 150.6 | 150.6 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
| 201 | 5883 | 5883.0 | 141.9 | 141.9 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 202 | 11752 | 5876.0 | 284.5 | 142.2 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 203 | 5868 | 5868.0 | 178.8 | 178.8 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 204 | 5865 | 5865.0 | 230.8 | 230.8 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 205 | 11682 | 5841.0 | 241.1 | 120.5 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 206 | 5823 | 5823.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D HARMAN | J Gerontol | 1956 | 13332224 | Yes |
| 207 | 5789 | 5789.0 | 214.8 | 214.8 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 208 | 17322 | 5774.0 | 636.6 | 212.2 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 209 | 5760 | 5760.0 | 216.7 | 216.7 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 210 | 11489 | 5744.5 | 247.2 | 123.6 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 211 | 5740 | 5740.0 | 142.2 | 142.2 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 212 | 5726 | 5726.0 | 119.2 | 119.2 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 213 | 11452 | 5726.0 | 193.3 | 96.7 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T OMURA, R SATO | J Biol Chem | 1964 | 14209971 | Yes |
| 214 | 11429 | 5714.5 | 722.2 | 361.1 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 215 | 11417 | 5708.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V HAMBURGER, H L HAMILTON | J Morphol | 1951 | 24539719 | Yes |
| 216 | 5705 | 5705.0 | 95.4 | 95.4 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 217 | 11382 | 5691.0 | 535.0 | 267.5 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 218 | 11349 | 5674.5 | 298.0 | 149.0 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 219 | 11264 | 5632.0 | 256.0 | 128.0 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stephane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 220 | 5620 | 5620.0 | 89.8 | 89.8 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 221 | 5599 | 5599.0 | 118.7 | 118.7 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 222 | 16786 | 5595.3 | 648.0 | 216.0 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 223 | 5594 | 5594.0 | 164.0 | 164.0 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 224 | 16751 | 5583.7 | 501.5 | 167.2 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 225 | 11110 | 5555.0 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L HODGKIN, A F HUXLEY | J Physiol | 1952 | 12991237 | Yes |
| 226 | 16664 | 5554.7 | 650.3 | 216.8 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 227 | 16587 | 5529.0 | 402.3 | 134.1 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 228 | 10962 | 5481.0 | 361.2 | 180.6 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 229 | 5474 | 5474.0 | 239.2 | 239.2 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniel Lakens | Front Psychol | 2013 | 24324449 | No |
| 230 | 10934 | 5467.0 | 284.8 | 142.4 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 231 | 5447 | 5447.0 | 103.2 | 103.2 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
| 232 | 5423 | 5423.0 | 53.3 | 53.3 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P LAUREN | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 233 | 10819 | 5409.5 | 299.9 | 149.9 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 234 | 5394 | 5394.0 | 135.5 | 135.5 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 235 | 26881 | 5376.2 | 719.4 | 143.9 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 236 | 5374 | 5374.0 | 127.8 | 127.8 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
| 237 | 10739 | 5369.5 | 227.3 | 113.7 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 238 | 5366 | 5366.0 | 104.4 | 104.4 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
| 239 | 5346 | 5346.0 | 127.3 | 127.3 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
| 240 | 10666 | 5333.0 | 251.2 | 125.6 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 241 | 5309 | 5309.0 | 134.8 | 134.8 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 242 | 15926 | 5308.7 | 548.9 | 183.0 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 243 | 5272 | 5272.0 | 151.5 | 151.5 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 244 | 10513 | 5256.5 | 180.8 | 90.4 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 245 | 5236 | 5236.0 | 188.7 | 188.7 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
| 246 | 5233 | 5233.0 | 157.7 | 157.7 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 247 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J SCHEIDEGGER | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 248 | 10434 | 5217.0 | 165.8 | 82.9 | Functional Evaluation: The Barthel Index. | F I MAHONEY, D W BARTHEL | Md State Med J | 1965 | 14258950 | Yes |
| 249 | 10417 | 5208.5 | 364.3 | 182.2 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 250 | 5204 | 5204.0 | 68.4 | 68.4 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 251 | 15576 | 5192.0 | 504.7 | 168.2 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 252 | 5177 | 5177.0 | 101.5 | 101.5 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 253 | 25818 | 5163.6 | 1035.2 | 207.0 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 254 | 10310 | 5155.0 | 360.2 | 180.1 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 255 | 10284 | 5142.0 | 271.9 | 135.9 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schagger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 256 | 10277 | 5138.5 | 264.4 | 132.2 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 257 | 5130 | 5130.0 | 188.1 | 188.1 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 258 | 5106 | 5106.0 | 144.1 | 144.1 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 259 | 10194 | 5097.0 | 238.3 | 119.2 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 260 | 5095 | 5095.0 | 113.7 | 113.7 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 261 | 15220 | 5073.3 | 477.9 | 159.3 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 262 | 15196 | 5065.3 | 659.6 | 219.9 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 263 | 20232 | 5058.0 | 626.4 | 156.6 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Lowe | Arch Intern Med | 2006 | 16717171 | Yes |
| 264 | 25274 | 5054.8 | 413.3 | 82.7 | An inventory for measuring depression. | A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 265 | 5043 | 5043.0 | 91.7 | 91.7 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
| 266 | 14997 | 4999.0 | 540.3 | 180.1 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 267 | 9972 | 4986.0 | 223.6 | 111.8 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 268 | 19847 | 4961.8 | 309.0 | 77.2 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 269 | 4949 | 4949.0 | 123.3 | 123.3 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 270 | 4939 | 4939.0 | 114.1 | 114.1 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 271 | 9843 | 4921.5 | 358.3 | 179.2 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 272 | 4912 | 4912.0 | 156.0 | 156.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 273 | 9785 | 4892.5 | 348.6 | 174.3 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 274 | 4891 | 4891.0 | 97.3 | 97.3 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
| 275 | 14657 | 4885.7 | 392.6 | 130.9 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 276 | 34191 | 4884.4 | 736.5 | 105.2 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 277 | 4863 | 4863.0 | 203.3 | 203.3 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 278 | 9724 | 4862.0 | 229.7 | 114.8 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 279 | 9700 | 4850.0 | 392.4 | 196.2 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 280 | 4847 | 4847.0 | 104.2 | 104.2 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
| 281 | 14515 | 4838.3 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G GORNALL, C J BARDAWILL, M M DAVID | J Biol Chem | 1949 | 18110453 | Yes |
| 282 | 4822 | 4822.0 | 107.4 | 107.4 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
| 283 | 4815 | 4815.0 | 40.6 | 40.6 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L HAYFLICK | Exp Cell Res | 1965 | 14315085 | Yes |
| 284 | 14443 | 4814.3 | 355.7 | 118.6 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 285 | 4812 | 4812.0 | 104.4 | 104.4 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 286 | 9618 | 4809.0 | 239.4 | 119.7 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 287 | 4806 | 4806.0 | 57.5 | 57.5 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M RODBELL | J Biol Chem | 1964 | 14169133 | Yes |
| 288 | 14384 | 4794.7 | 309.4 | 103.1 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 289 | 4794 | 4794.0 | 104.3 | 104.3 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
| 290 | 4789 | 4789.0 | 130.2 | 130.2 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 291 | 9530 | 4765.0 | 155.3 | 77.7 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 292 | 9522 | 4761.0 | 362.7 | 181.3 | The qualitative content analysis process. | Satu Elo, Helvi Kyngas | J Adv Nurs | 2008 | 18352969 | Yes |
| 293 | 4760 | 4760.0 | 94.8 | 94.8 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
| 294 | 9481 | 4740.5 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H KELLGREN, J S LAWRENCE | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 295 | 9469 | 4734.5 | 236.7 | 118.3 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 296 | 23612 | 4722.4 | 892.2 | 178.4 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 297 | 4714 | 4714.0 | 265.2 | 265.2 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V BORN | Nature | 1962 | 13871375 | Yes |
| 298 | 4711 | 4711.0 | 135.6 | 135.6 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 299 | 4707 | 4707.0 | 155.8 | 155.8 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
| 300 | 4707 | 4707.0 | 143.6 | 143.6 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 301 | 9398 | 4699.0 | 136.5 | 68.2 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 302 | 9378 | 4689.0 | 255.3 | 127.7 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 303 | 4681 | 4681.0 | 49.0 | 49.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 304 | 4678 | 4678.0 | 129.5 | 129.5 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 305 | 18705 | 4676.2 | 519.8 | 129.9 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 306 | 9335 | 4667.5 | 229.2 | 114.6 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 307 | 4667 | 4667.0 | 173.2 | 173.2 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 308 | 4666 | 4666.0 | 95.9 | 95.9 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 309 | 4661 | 4661.0 | 120.4 | 120.4 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 310 | 9284 | 4642.0 | 202.6 | 101.3 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 311 | 9261 | 4630.5 | 289.5 | 144.8 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoc, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 312 | 4629 | 4629.0 | 165.2 | 165.2 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 313 | 4626 | 4626.0 | 91.5 | 91.5 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 314 | 4608 | 4608.0 | 104.3 | 104.3 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 315 | 9210 | 4605.0 | 263.8 | 131.9 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 316 | 4586 | 4586.0 | 124.6 | 124.6 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 317 | 13740 | 4580.0 | 469.6 | 156.5 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
| 318 | 13709 | 4569.7 | 498.1 | 166.0 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 319 | 9128 | 4564.0 | 241.7 | 120.8 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 320 | 4553 | 4553.0 | 96.8 | 96.8 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
| 321 | 9101 | 4550.5 | 208.2 | 104.1 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 322 | 4541 | 4541.0 | 86.8 | 86.8 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 323 | 4539 | 4539.0 | 163.7 | 163.7 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 324 | 4533 | 4533.0 | 90.9 | 90.9 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 325 | 4530 | 4530.0 | 84.5 | 84.5 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 326 | 4486 | 4486.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B DE B WEIR | J Physiol | 1949 | 15394301 | Yes |
| 327 | 4481 | 4481.0 | 134.6 | 134.6 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
| 328 | 4476 | 4476.0 | 106.0 | 106.0 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 329 | 4472 | 4472.0 | 112.1 | 112.1 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 330 | 26794 | 4465.7 | 863.6 | 143.9 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 331 | 4463 | 4463.0 | 112.3 | 112.3 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 332 | 8924 | 4462.0 | 208.7 | 104.3 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 333 | 4442 | 4442.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 334 | 8880 | 4440.0 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T LITCHFIELD, F WILCOXON | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 335 | 4437 | 4437.0 | 107.3 | 107.3 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 336 | 4432 | 4432.0 | 111.4 | 111.4 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 337 | 26550 | 4425.0 | 913.1 | 152.2 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 338 | 4422 | 4422.0 | 91.3 | 91.3 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 339 | 4415 | 4415.0 | 101.9 | 101.9 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 340 | 4415 | 4415.0 | 112.6 | 112.6 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
| 341 | 4407 | 4407.0 | 93.1 | 93.1 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 342 | 8771 | 4385.5 | 162.0 | 81.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 343 | 4355 | 4355.0 | 221.4 | 221.4 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 344 | 8702 | 4351.0 | 266.5 | 133.2 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 345 | 4351 | 4351.0 | 119.2 | 119.2 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 346 | 4348 | 4348.0 | 111.2 | 111.2 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 347 | 21730 | 4346.0 | 1234.8 | 247.0 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 348 | 4341 | 4341.0 | 128.2 | 128.2 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 349 | 8682 | 4341.0 | 220.2 | 110.1 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 350 | 43241 | 4324.1 | 1046.2 | 104.6 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, | Bioinformatics | 2009 | 19505943 | Yes |
| 351 | 4322 | 4322.0 | 106.9 | 106.9 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
| 352 | 8641 | 4320.5 | 215.4 | 107.7 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
| 353 | 8615 | 4307.5 | 226.2 | 113.1 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 354 | 4302 | 4302.0 | 113.2 | 113.2 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
| 355 | 4295 | 4295.0 | 93.9 | 93.9 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 356 | 8585 | 4292.5 | 466.6 | 233.3 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M HUNTER, F C GREENWOOD | Nature | 1962 | 14450081 | Yes |
| 357 | 4283 | 4283.0 | 87.6 | 87.6 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 358 | 4280 | 4280.0 | 91.6 | 91.6 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 359 | 4279 | 4279.0 | 142.0 | 142.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 360 | 4277 | 4277.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M ABERCROMBIE | Anat Rec | 1946 | 21015608 | Yes |
| 361 | 4274 | 4274.0 | 112.7 | 112.7 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 362 | 4272 | 4272.0 | 171.6 | 171.6 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 363 | 4272 | 4272.0 | 75.4 | 75.4 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 364 | 4264 | 4264.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T NASH | Biochem J | 1953 | 13105648 | Yes |
| 365 | 4250 | 4250.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H EAGLE | Science | 1959 | 13675766 | Yes |
| 366 | 4249 | 4249.0 | 120.6 | 120.6 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 367 | 4247 | 4247.0 | 100.0 | 100.0 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 368 | 4246 | 4246.0 | 72.3 | 72.3 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 369 | 4242 | 4242.0 | 86.5 | 86.5 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
| 370 | 4241 | 4241.0 | 50.3 | 50.3 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 371 | 4240 | 4240.0 | 108.4 | 108.4 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 372 | 4235 | 4235.0 | 80.6 | 80.6 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
| 373 | 4230 | 4230.0 | 100.8 | 100.8 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 374 | 4223 | 4223.0 | 120.0 | 120.0 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
| 375 | 4222 | 4222.0 | 93.7 | 93.7 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 376 | 4221 | 4221.0 | 111.1 | 111.1 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 377 | 8438 | 4219.0 | 178.9 | 89.5 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 378 | 4205 | 4205.0 | 175.1 | 175.1 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 379 | 4202 | 4202.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P DOLE | J Clin Invest | 1956 | 13286333 | Yes |
| 380 | 8401 | 4200.5 | 217.0 | 108.5 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | No |
| 381 | 4199 | 4199.0 | 86.4 | 86.4 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 382 | 12579 | 4193.0 | 318.7 | 106.2 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 383 | 4183 | 4183.0 | 145.8 | 145.8 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
| 384 | 4179 | 4179.0 | 86.0 | 86.0 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 385 | 16690 | 4172.5 | 739.4 | 184.8 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 386 | 4168 | 4168.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M DIXON | Biochem J | 1953 | 13093635 | Yes |
| 387 | 8335 | 4167.5 | 193.6 | 96.8 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 388 | 4158 | 4158.0 | 111.7 | 111.7 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 389 | 4150 | 4150.0 | 127.9 | 127.9 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
| 390 | 4145 | 4145.0 | 114.7 | 114.7 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
| 391 | 16578 | 4144.5 | 366.9 | 91.7 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 392 | 16567 | 4141.8 | 580.9 | 145.2 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 393 | 8280 | 4140.0 | 177.1 | 88.5 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 394 | 4126 | 4126.0 | 102.0 | 102.0 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
| 395 | 4124 | 4124.0 | 100.6 | 100.6 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 396 | 4122 | 4122.0 | 70.2 | 70.2 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 397 | 4081 | 4081.0 | 133.8 | 133.8 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 398 | 8159 | 4079.5 | 195.3 | 97.7 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
| 399 | 4078 | 4078.0 | 106.4 | 106.4 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 400 | 4067 | 4067.0 | 91.5 | 91.5 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
| 401 | 8087 | 4043.5 | 198.1 | 99.0 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
| 402 | 12115 | 4038.3 | 322.9 | 107.6 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
| 403 | 8064 | 4032.0 | 151.6 | 75.8 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 404 | 4030 | 4030.0 | 82.0 | 82.0 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 405 | 4029 | 4029.0 | 103.0 | 103.0 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 406 | 8057 | 4028.5 | 151.6 | 75.8 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 407 | 4022 | 4022.0 | 106.8 | 106.8 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
| 408 | 12064 | 4021.3 | 281.9 | 94.0 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 409 | 4006 | 4006.0 | 82.0 | 82.0 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
| 410 | 4006 | 4006.0 | 114.9 | 114.9 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 411 | 4004 | 4004.0 | 127.8 | 127.8 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
| 412 | 8008 | 4004.0 | 261.0 | 130.5 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 413 | 3995 | 3995.0 | 87.2 | 87.2 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 414 | 3993 | 3993.0 | 143.1 | 143.1 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 415 | 35783 | 3975.9 | 1060.9 | 117.9 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 416 | 7949 | 3974.5 | 212.1 | 106.0 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 417 | 3972 | 3972.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L WATSON | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 418 | 3970 | 3970.0 | 113.0 | 113.0 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 419 | 3970 | 3970.0 | 94.7 | 94.7 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
| 420 | 27656 | 3950.9 | 937.8 | 134.0 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 421 | 3939 | 3939.0 | 92.3 | 92.3 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 422 | 3932 | 3932.0 | 119.5 | 119.5 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | Francois Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 423 | 7850 | 3925.0 | 218.9 | 109.5 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 424 | 3925 | 3925.0 | 118.3 | 118.3 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 425 | 3923 | 3923.0 | 120.2 | 120.2 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
| 426 | 3923 | 3923.0 | 116.9 | 116.9 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 427 | 3917 | 3917.0 | 64.0 | 64.0 | Disc Electrophoresis. I. Background And Theory. | L ORNSTEIN | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 428 | 3914 | 3914.0 | 143.2 | 143.2 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 429 | 3912 | 3912.0 | 102.9 | 102.9 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 430 | 11733 | 3911.0 | 367.1 | 122.4 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 431 | 3910 | 3910.0 | 76.0 | 76.0 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 432 | 3907 | 3907.0 | 173.9 | 173.9 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 433 | 3907 | 3907.0 | 94.8 | 94.8 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
| 434 | 15616 | 3904.0 | 625.5 | 156.4 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 435 | 35105 | 3900.6 | 741.4 | 82.4 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 436 | 3899 | 3899.0 | 109.6 | 109.6 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
| 437 | 3895 | 3895.0 | 90.4 | 90.4 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 438 | 3885 | 3885.0 | 125.8 | 125.8 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
| 439 | 3882 | 3882.0 | 90.9 | 90.9 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
| 440 | 3880 | 3880.0 | 88.7 | 88.7 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 441 | 3874 | 3874.0 | 98.7 | 98.7 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 442 | 3840 | 3840.0 | 122.3 | 122.3 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 443 | 7671 | 3835.5 | 176.7 | 88.3 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 444 | 3834 | 3834.0 | 102.3 | 102.3 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 445 | 3833 | 3833.0 | 98.4 | 98.4 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 446 | 3832 | 3832.0 | 98.9 | 98.9 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
| 447 | 3817 | 3817.0 | 77.4 | 77.4 | TGF-beta signal transduction. | J Massague | Annu Rev Biochem | 1998 | 9759503 | No |
| 448 | 7632 | 3816.0 | 180.9 | 90.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 449 | 3813 | 3813.0 | 120.9 | 120.9 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 450 | 7621 | 3810.5 | 226.1 | 113.0 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 451 | 3803 | 3803.0 | 89.6 | 89.6 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brunger | Nature | 1992 | 18481394 | Yes |
| 452 | 3798 | 3798.0 | 79.3 | 79.3 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 453 | 7572 | 3786.0 | 163.6 | 81.8 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 454 | 3782 | 3782.0 | 91.3 | 91.3 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 455 | 7556 | 3778.0 | 380.0 | 190.0 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 456 | 3758 | 3758.0 | 65.1 | 65.1 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 457 | 3753 | 3753.0 | 107.2 | 107.2 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 458 | 3751 | 3751.0 | 66.1 | 66.1 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 459 | 11231 | 3743.7 | 213.8 | 71.3 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 460 | 3743 | 3743.0 | 166.4 | 166.4 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 461 | 11221 | 3740.3 | 258.6 | 86.2 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 462 | 7452 | 3726.0 | 232.0 | 116.0 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 463 | 3720 | 3720.0 | 76.7 | 76.7 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 464 | 7429 | 3714.5 | 270.8 | 135.4 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 465 | 3705 | 3705.0 | 101.7 | 101.7 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 466 | 3704 | 3704.0 | 68.4 | 68.4 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 467 | 7381 | 3690.5 | 413.5 | 206.8 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | No |
| 468 | 18376 | 3675.2 | 655.9 | 131.2 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Ann Intern Med | 2009 | 19622511 | No |
| 469 | 3670 | 3670.0 | 118.2 | 118.2 | The Danish Civil Registration System. | Carsten Bocker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 470 | 10989 | 3663.0 | 1034.4 | 344.8 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 471 | 3659 | 3659.0 | 115.6 | 115.6 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 472 | 10977 | 3659.0 | 254.6 | 84.9 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 473 | 3656 | 3656.0 | 81.3 | 81.3 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
| 474 | 7291 | 3645.5 | 128.7 | 64.3 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 475 | 3644 | 3644.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A MILLER | Psychol Rev | 1956 | 13310704 | Yes |
| 476 | 10906 | 3635.3 | 256.6 | 85.5 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 477 | 3635 | 3635.0 | 71.1 | 71.1 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 478 | 3635 | 3635.0 | 126.1 | 126.1 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 479 | 7269 | 3634.5 | 169.5 | 84.8 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 480 | 3634 | 3634.0 | 166.9 | 166.9 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 481 | 3631 | 3631.0 | 84.0 | 84.0 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 482 | 7254 | 3627.0 | 366.4 | 183.2 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H HUBEL, T N WIESEL | J Physiol | 1962 | 14449617 | Yes |
| 483 | 3626 | 3626.0 | 79.9 | 79.9 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
| 484 | 3625 | 3625.0 | 100.7 | 100.7 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 485 | 7241 | 3620.5 | 203.4 | 101.7 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 486 | 3619 | 3619.0 | 133.4 | 133.4 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
| 487 | 3618 | 3618.0 | 123.3 | 123.3 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
| 488 | 3617 | 3617.0 | 53.8 | 53.8 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 489 | 3611 | 3611.0 | 108.2 | 108.2 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
| 490 | 3611 | 3611.0 | 139.8 | 139.8 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 491 | 3610 | 3610.0 | 106.5 | 106.5 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 492 | 3603 | 3603.0 | 67.0 | 67.0 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 493 | 7197 | 3598.5 | 208.7 | 104.3 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
| 494 | 3594 | 3594.0 | 91.8 | 91.8 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
| 495 | 7188 | 3594.0 | 137.9 | 69.0 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 496 | 7178 | 3589.0 | 199.1 | 99.5 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
| 497 | 3587 | 3587.0 | 85.8 | 85.8 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 498 | 39393 | 3581.2 | 800.9 | 72.8 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 499 | 14324 | 3581.0 | 796.5 | 199.1 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 500 | 3578 | 3578.0 | 76.4 | 76.4 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
| 501 | 3555 | 3555.0 | 85.8 | 85.8 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
| 502 | 7077 | 3538.5 | 144.9 | 72.5 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 503 | 17647 | 3529.4 | 612.6 | 122.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | BMJ | 2009 | 19622551 | No |
| 504 | 3529 | 3529.0 | 109.7 | 109.7 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
| 505 | 3526 | 3526.0 | 57.0 | 57.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 506 | 10576 | 3525.3 | 284.9 | 95.0 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hanzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 507 | 7049 | 3524.5 | 132.8 | 66.4 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
| 508 | 3524 | 3524.0 | 139.0 | 139.0 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 509 | 3519 | 3519.0 | 51.2 | 51.2 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F WOESSNER | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 510 | 17594 | 3518.8 | 493.9 | 98.8 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 511 | 3516 | 3516.0 | 94.4 | 94.4 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 512 | 7023 | 3511.5 | 209.5 | 104.8 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 513 | 3509 | 3509.0 | 77.3 | 77.3 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
| 514 | 3506 | 3506.0 | 87.4 | 87.4 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 515 | 6990 | 3495.0 | 161.1 | 80.5 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
| 516 | 3488 | 3488.0 | 69.6 | 69.6 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 517 | 3485 | 3485.0 | 57.5 | 57.5 | Statistical estimations in enzyme kinetics. | G N WILKINSON | Biochem J | 1961 | 13785321 | Yes |
| 518 | 3484 | 3484.0 | 80.0 | 80.0 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
| 519 | 6968 | 3484.0 | 183.3 | 91.7 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 520 | 6954 | 3477.0 | 583.8 | 291.9 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 521 | 3476 | 3476.0 | 94.6 | 94.6 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 522 | 3474 | 3474.0 | 82.7 | 82.7 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
| 523 | 6948 | 3474.0 | 192.6 | 96.3 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 524 | 3474 | 3474.0 | 150.1 | 150.1 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
| 525 | 6928 | 3464.0 | 181.6 | 90.8 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 526 | 3463 | 3463.0 | 82.4 | 82.4 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 527 | 6926 | 3463.0 | 143.1 | 71.5 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 528 | 3459 | 3459.0 | 65.4 | 65.4 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
| 529 | 3452 | 3452.0 | 76.9 | 76.9 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
| 530 | 6901 | 3450.5 | 172.0 | 86.0 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
| 531 | 6879 | 3439.5 | 171.4 | 85.7 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
| 532 | 6878 | 3439.0 | 162.3 | 81.2 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 533 | 3435 | 3435.0 | 91.7 | 91.7 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 534 | 27479 | 3434.9 | 582.3 | 72.8 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 535 | 3434 | 3434.0 | 70.2 | 70.2 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 536 | 3427 | 3427.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W KAUZMANN | Adv Protein Chem | 1959 | 14404936 | Yes |
| 537 | 6849 | 3424.5 | 213.5 | 106.8 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 538 | 6836 | 3418.0 | 205.1 | 102.5 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 539 | 3403 | 3403.0 | 68.8 | 68.8 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 540 | 3403 | 3403.0 | 160.3 | 160.3 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | No |
| 541 | 6778 | 3389.0 | 211.9 | 106.0 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 542 | 10157 | 3385.7 | 98.2 | 32.7 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C GREENWOOD, W M HUNTER, J S GLOVER | Biochem J | 1963 | 14097352 | Yes |
| 543 | 3385 | 3385.0 | 113.3 | 113.3 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 544 | 6769 | 3384.5 | 218.4 | 109.2 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 545 | 6766 | 3383.0 | 161.3 | 80.7 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 546 | 10145 | 3381.7 | 278.9 | 93.0 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 547 | 3376 | 3376.0 | 76.4 | 76.4 | Photoelectrochemical cells. | M Gratzel | Nature | 2001 | 11713540 | Yes |
| 548 | 6751 | 3375.5 | 271.8 | 135.9 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 549 | 6740 | 3370.0 | 185.2 | 92.6 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 550 | 3369 | 3369.0 | 68.5 | 68.5 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
| 551 | 3366 | 3366.0 | 107.3 | 107.3 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 552 | 3362 | 3362.0 | 173.9 | 173.9 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | No |
| 553 | 6710 | 3355.0 | 55.9 | 27.9 | The serial cultivation of human diploid cell strains. | L HAYFLICK, P S MOORHEAD | Exp Cell Res | 1961 | 13905658 | Yes |
| 554 | 3354 | 3354.0 | 100.4 | 100.4 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
| 555 | 3354 | 3354.0 | 60.2 | 60.2 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 556 | 10053 | 3351.0 | 280.0 | 93.3 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 557 | 3340 | 3340.0 | 95.7 | 95.7 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 558 | 3338 | 3338.0 | 67.9 | 67.9 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 559 | 6670 | 3335.0 | 103.6 | 51.8 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 560 | 3329 | 3329.0 | 87.9 | 87.9 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
| 561 | 9970 | 3323.3 | 475.0 | 158.3 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
| 562 | 3323 | 3323.0 | 75.2 | 75.2 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 563 | 3319 | 3319.0 | 51.6 | 51.6 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L HORN | Psychometrika | 1965 | 14306381 | Yes |
| 564 | 3317 | 3317.0 | 175.2 | 175.2 | Obesity: global epidemiology and pathogenesis. | Matthias Bluher | Nat Rev Endocrinol | 2019 | 30814686 | No |
| 565 | 3314 | 3314.0 | 78.1 | 78.1 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 566 | 6621 | 3310.5 | 162.7 | 81.3 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 567 | 3309 | 3309.0 | 101.8 | 101.8 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 568 | 3307 | 3307.0 | 83.6 | 83.6 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 569 | 9901 | 3300.3 | 182.5 | 60.8 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 570 | 3299 | 3299.0 | 46.2 | 46.2 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A YPHANTIS | Biochemistry | 1964 | 14155091 | Yes |
| 571 | 13181 | 3295.2 | 491.1 | 122.8 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 572 | 3295 | 3295.0 | 69.6 | 69.6 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 573 | 3290 | 3290.0 | 111.2 | 111.2 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 574 | 3288 | 3288.0 | 64.1 | 64.1 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 575 | 3287 | 3287.0 | 74.8 | 74.8 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
| 576 | 6570 | 3285.0 | 162.4 | 81.2 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 577 | 3283 | 3283.0 | 126.4 | 126.4 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 578 | 3283 | 3283.0 | 71.1 | 71.1 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 579 | 3280 | 3280.0 | 66.8 | 66.8 | TGFbeta in Cancer. | Joan Massague | Cell | 2008 | 18662538 | No |
| 580 | 3264 | 3264.0 | 95.8 | 95.8 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
| 581 | 3262 | 3262.0 | 66.2 | 66.2 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 582 | 3260 | 3260.0 | 159.6 | 159.6 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 583 | 6516 | 3258.0 | 133.7 | 66.8 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
| 584 | 9770 | 3256.7 | 410.8 | 136.9 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 585 | 3256 | 3256.0 | 87.0 | 87.0 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
| 586 | 13004 | 3251.0 | 298.0 | 74.5 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 587 | 3250 | 3250.0 | 66.1 | 66.1 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
| 588 | 3247 | 3247.0 | 93.1 | 93.1 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
| 589 | 3238 | 3238.0 | 59.1 | 59.1 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 590 | 3233 | 3233.0 | 110.6 | 110.6 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 591 | 3232 | 3232.0 | 26.9 | 26.9 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F LYON | Nature | 1961 | 13764598 | Yes |
| 592 | 6455 | 3227.5 | 298.7 | 149.3 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 593 | 6435 | 3217.5 | 110.3 | 55.1 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 594 | 3216 | 3216.0 | 142.9 | 142.9 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 595 | 3216 | 3216.0 | 66.2 | 66.2 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
| 596 | 3216 | 3216.0 | 71.3 | 71.3 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
| 597 | 19295 | 3215.8 | 905.5 | 150.9 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 598 | 12827 | 3206.8 | 360.4 | 90.1 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 599 | 3204 | 3204.0 | 105.9 | 105.9 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 600 | 3201 | 3201.0 | 73.7 | 73.7 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 601 | 6397 | 3198.5 | 140.8 | 70.4 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 602 | 3196 | 3196.0 | 86.4 | 86.4 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
| 603 | 3193 | 3193.0 | 85.9 | 85.9 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
| 604 | 9565 | 3188.3 | 193.5 | 64.5 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 605 | 3184 | 3184.0 | 126.4 | 126.4 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 606 | 3178 | 3178.0 | 73.4 | 73.4 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 607 | 6355 | 3177.5 | 135.2 | 67.6 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
| 608 | 6353 | 3176.5 | 162.8 | 81.4 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 609 | 3176 | 3176.0 | 96.3 | 96.3 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 610 | 3176 | 3176.0 | 104.8 | 104.8 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
| 611 | 3172 | 3172.0 | 74.3 | 74.3 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 612 | 3172 | 3172.0 | 68.9 | 68.9 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
| 613 | 3168 | 3168.0 | 77.7 | 77.7 | The transforming growth factor-beta family. | J Massague | Annu Rev Cell Biol | 1990 | 2177343 | No |
| 614 | 6334 | 3167.0 | 131.8 | 65.9 | Emergence of scaling in random networks | A L Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 615 | 6329 | 3164.5 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S REITMAN, S FRANKEL | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 616 | 6327 | 3163.5 | 148.6 | 74.3 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 617 | 3142 | 3142.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O OUCHTERLONY | Prog Allergy | 1958 | 13578996 | Yes |
| 618 | 9400 | 3133.3 | 233.7 | 77.9 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 619 | 9377 | 3125.7 | 310.9 | 103.6 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 620 | 3125 | 3125.0 | 73.4 | 73.4 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 621 | 3120 | 3120.0 | 93.4 | 93.4 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 622 | 3119 | 3119.0 | 113.0 | 113.0 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 623 | 3108 | 3108.0 | 72.5 | 72.5 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 624 | 9305 | 3101.7 | 297.7 | 99.2 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 625 | 9305 | 3101.7 | 214.1 | 71.4 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 626 | 6197 | 3098.5 | 125.8 | 62.9 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 627 | 3095 | 3095.0 | 93.6 | 93.6 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 628 | 12363 | 3090.8 | 283.6 | 70.9 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 629 | 9265 | 3088.3 | 203.2 | 67.7 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 630 | 3083 | 3083.0 | 59.6 | 59.6 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
| 631 | 6159 | 3079.5 | 192.0 | 96.0 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graca Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
| 632 | 6137 | 3068.5 | 145.5 | 72.8 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 633 | 3066 | 3066.0 | 84.6 | 84.6 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 634 | 3066 | 3066.0 | 70.0 | 70.0 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 635 | 3063 | 3063.0 | 47.5 | 47.5 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S HAKOMORI | J Biochem | 1964 | 14135466 | Yes |
| 636 | 3058 | 3058.0 | 29.6 | 29.6 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P MITCHELL | Nature | 1961 | 13771349 | Yes |
| 637 | 3050 | 3050.0 | 94.8 | 94.8 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 638 | 6097 | 3048.5 | 187.9 | 94.0 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 639 | 3044 | 3044.0 | 74.1 | 74.1 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
| 640 | 3043 | 3043.0 | 54.9 | 54.9 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 641 | 3040 | 3040.0 | 129.1 | 129.1 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 642 | 9114 | 3038.0 | 174.9 | 58.3 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 643 | 3037 | 3037.0 | 89.0 | 89.0 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
| 644 | 3037 | 3037.0 | 127.3 | 127.3 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
| 645 | 3036 | 3036.0 | 55.9 | 55.9 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 646 | 3033 | 3033.0 | 0.0 | 0.0 | The genetical structure of populations. | S WRIGHT | Ann Eugen | 1951 | 24540312 | Yes |
| 647 | 3032 | 3032.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I SELDINGER | Acta Radiol (Stockh) | 1953 | 13057644 | Yes |
| 648 | 3031 | 3031.0 | 66.2 | 66.2 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 649 | 6059 | 3029.5 | 234.9 | 117.5 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 650 | 3012 | 3012.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E PALADE | J Exp Med | 1952 | 14927794 | Yes |
| 651 | 3009 | 3009.0 | 70.5 | 70.5 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 652 | 3004 | 3004.0 | 131.8 | 131.8 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 653 | 3003 | 3003.0 | 56.6 | 56.6 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
| 654 | 2996 | 2996.0 | 57.4 | 57.4 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
| 655 | 2994 | 2994.0 | 67.9 | 67.9 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
| 656 | 2992 | 2992.0 | 83.6 | 83.6 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
| 657 | 2992 | 2992.0 | 92.0 | 92.0 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 658 | 8951 | 2983.7 | 195.1 | 65.0 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 659 | 5965 | 2982.5 | 124.9 | 62.5 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 660 | 2980 | 2980.0 | 91.0 | 91.0 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
| 661 | 5957 | 2978.5 | 180.2 | 90.1 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 662 | 5954 | 2977.0 | 177.1 | 88.5 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
| 663 | 5953 | 2976.5 | 171.0 | 85.5 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
| 664 | 5952 | 2976.0 | 195.6 | 97.8 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 665 | 2976 | 2976.0 | 61.4 | 61.4 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 666 | 2975 | 2975.0 | 51.8 | 51.8 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 667 | 2973 | 2973.0 | 73.1 | 73.1 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 668 | 5944 | 2972.0 | 200.6 | 100.3 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 669 | 5925 | 2962.5 | 166.3 | 83.2 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 670 | 8881 | 2960.3 | 241.7 | 80.6 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 671 | 2959 | 2959.0 | 73.0 | 73.0 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 672 | 2955 | 2955.0 | 61.9 | 61.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
| 673 | 2951 | 2951.0 | 44.3 | 44.3 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
| 674 | 5893 | 2946.5 | 125.3 | 62.6 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
| 675 | 2945 | 2945.0 | 57.9 | 57.9 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 676 | 2943 | 2943.0 | 60.4 | 60.4 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 677 | 2939 | 2939.0 | 75.9 | 75.9 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 678 | 17632 | 2938.7 | 378.3 | 63.1 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 679 | 2935 | 2935.0 | 52.4 | 52.4 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 680 | 2934 | 2934.0 | 68.8 | 68.8 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
| 681 | 5866 | 2933.0 | 130.6 | 65.3 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 682 | 2930 | 2930.0 | 48.8 | 48.8 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
| 683 | 2928 | 2928.0 | 86.8 | 86.8 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 684 | 2927 | 2927.0 | 73.8 | 73.8 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 685 | 2920 | 2920.0 | 87.1 | 87.1 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
| 686 | 2918 | 2918.0 | 77.7 | 77.7 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
| 687 | 8742 | 2914.0 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J HAVEL, H A EDER, J H BRAGDON | J Clin Invest | 1955 | 13252080 | Yes |
| 688 | 5826 | 2913.0 | 161.6 | 80.8 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 689 | 2911 | 2911.0 | 70.7 | 70.7 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 690 | 5814 | 2907.0 | 249.6 | 124.8 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 691 | 2904 | 2904.0 | 94.0 | 94.0 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
| 692 | 5805 | 2902.5 | 154.2 | 77.1 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
| 693 | 2899 | 2899.0 | 95.3 | 95.3 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 694 | 2895 | 2895.0 | 0.0 | 0.0 | Notes on sugar determination. | M SMOGYI | J Biol Chem | 1952 | 14938350 | Yes |
| 695 | 5783 | 2891.5 | 115.3 | 57.6 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 696 | 2890 | 2890.0 | 60.9 | 60.9 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 697 | 2890 | 2890.0 | 48.9 | 48.9 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A GEHAN | Biometrika | 1965 | 14341275 | Yes |
| 698 | 2887 | 2887.0 | 128.4 | 128.4 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 699 | 5771 | 2885.5 | 195.3 | 97.7 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 700 | 2883 | 2883.0 | 112.6 | 112.6 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 701 | 2882 | 2882.0 | 83.4 | 83.4 | Separation of leukocytes from blood and bone marrow. Introduction. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 702 | 5756 | 2878.0 | 173.0 | 86.5 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 703 | 5752 | 2876.0 | 111.1 | 55.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
| 704 | 2874 | 2874.0 | 50.5 | 50.5 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 705 | 5744 | 2872.0 | 148.0 | 74.0 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 706 | 2871 | 2871.0 | 72.3 | 72.3 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
| 707 | 2865 | 2865.0 | 92.5 | 92.5 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 708 | 2864 | 2864.0 | 82.6 | 82.6 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 709 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C SCHNEIDER | J Biol Chem | 1945 | 21005736 | Yes |
| 710 | 5710 | 2855.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D WATSON, F H CRICK | Nature | 1953 | 13054692 | Yes |
| 711 | 8556 | 2852.0 | 246.9 | 82.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 712 | 8551 | 2850.3 | 223.5 | 74.5 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 713 | 2847 | 2847.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P AHLQUIST | Am J Physiol | 1948 | 18882199 | Yes |
| 714 | 2842 | 2842.0 | 69.0 | 69.0 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
| 715 | 2839 | 2839.0 | 96.5 | 96.5 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 716 | 5674 | 2837.0 | 203.1 | 101.5 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 717 | 5674 | 2837.0 | 173.6 | 86.8 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 718 | 2837 | 2837.0 | 84.1 | 84.1 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | No |
| 719 | 8511 | 2837.0 | 335.9 | 112.0 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 720 | 2833 | 2833.0 | 64.1 | 64.1 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 721 | 2830 | 2830.0 | 110.9 | 110.9 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 722 | 2830 | 2830.0 | 56.7 | 56.7 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 723 | 2830 | 2830.0 | 65.3 | 65.3 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 724 | 5656 | 2828.0 | 158.8 | 79.4 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 725 | 5653 | 2826.5 | 179.5 | 89.8 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
| 726 | 2825 | 2825.0 | 64.0 | 64.0 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 727 | 5645 | 2822.5 | 135.2 | 67.6 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 728 | 2822 | 2822.0 | 111.7 | 111.7 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 729 | 2822 | 2822.0 | 65.4 | 65.4 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 730 | 5641 | 2820.5 | 134.0 | 67.0 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 731 | 5629 | 2814.5 | 132.5 | 66.2 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 732 | 5619 | 2809.5 | 125.4 | 62.7 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 733 | 2809 | 2809.0 | 65.5 | 65.5 | P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 734 | 5610 | 2805.0 | 152.0 | 76.0 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 735 | 5610 | 2805.0 | 315.5 | 157.8 | A modified uronic acid carbazole reaction. | T BITTER, H M MUIR | Anal Biochem | 1962 | 13971270 | Yes |
| 736 | 11214 | 2803.5 | 260.8 | 65.2 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
| 737 | 8393 | 2797.7 | 213.5 | 71.2 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 738 | 2797 | 2797.0 | 52.8 | 52.8 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 739 | 2797 | 2797.0 | 60.9 | 60.9 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
| 740 | 11188 | 2797.0 | 320.3 | 80.1 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 741 | 2796 | 2796.0 | 23.7 | 23.7 | Satellite cell of skeletal muscle fibers. | A MAURO | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 742 | 2794 | 2794.0 | 66.4 | 66.4 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
| 743 | 2791 | 2791.0 | 145.1 | 145.1 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 744 | 2790 | 2790.0 | 61.8 | 61.8 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
| 745 | 5580 | 2790.0 | 76.0 | 38.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G MARTIN, B N AMES | J Biol Chem | 1961 | 13767412 | Yes |
| 746 | 2790 | 2790.0 | 107.6 | 107.6 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
| 747 | 2789 | 2789.0 | 102.3 | 102.3 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 748 | 2786 | 2786.0 | 61.3 | 61.3 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 749 | 5571 | 2785.5 | 167.5 | 83.8 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
| 750 | 2785 | 2785.0 | 87.8 | 87.8 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 751 | 11134 | 2783.5 | 293.0 | 73.2 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 752 | 11131 | 2782.8 | 321.4 | 80.3 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 753 | 8345 | 2781.7 | 207.7 | 69.2 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 754 | 2779 | 2779.0 | 98.1 | 98.1 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 755 | 2778 | 2778.0 | 61.7 | 61.7 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 756 | 5555 | 2777.5 | 159.9 | 80.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 757 | 2777 | 2777.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 758 | 2775 | 2775.0 | 60.3 | 60.3 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 759 | 2772 | 2772.0 | 75.2 | 75.2 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 760 | 2772 | 2772.0 | 68.2 | 68.2 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 761 | 5533 | 2766.5 | 109.1 | 54.5 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J SILNESS, H LOE | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 762 | 2761 | 2761.0 | 70.0 | 70.0 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
| 763 | 5522 | 2761.0 | 124.9 | 62.5 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 764 | 8283 | 2761.0 | 407.3 | 135.8 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 765 | 8280 | 2760.0 | 238.1 | 79.4 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 766 | 2759 | 2759.0 | 65.7 | 65.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
| 767 | 5510 | 2755.0 | 217.5 | 108.8 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 768 | 2753 | 2753.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L SVENNERHOLM | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 769 | 2753 | 2753.0 | 108.4 | 108.4 | Deep learning in neural networks: an overview. | Jurgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
| 770 | 5483 | 2741.5 | 107.8 | 53.9 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 771 | 8219 | 2739.7 | 195.3 | 65.1 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
| 772 | 5477 | 2738.5 | 109.7 | 54.9 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
| 773 | 5470 | 2735.0 | 142.8 | 71.4 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 774 | 5465 | 2732.5 | 137.0 | 68.5 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 775 | 2732 | 2732.0 | 50.2 | 50.2 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
| 776 | 5461 | 2730.5 | 119.1 | 59.5 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
| 777 | 2729 | 2729.0 | 74.0 | 74.0 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
| 778 | 2726 | 2726.0 | 55.2 | 55.2 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 779 | 2722 | 2722.0 | 56.6 | 56.6 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
| 780 | 5442 | 2721.0 | 102.7 | 51.4 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
| 781 | 2718 | 2718.0 | 82.2 | 82.2 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 782 | 8151 | 2717.0 | 174.3 | 58.1 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 783 | 5434 | 2717.0 | 131.8 | 65.9 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 784 | 8143 | 2714.3 | 324.6 | 108.2 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 785 | 2714 | 2714.0 | 58.1 | 58.1 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
| 786 | 2714 | 2714.0 | 51.3 | 51.3 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
| 787 | 5426 | 2713.0 | 233.3 | 116.7 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 788 | 43385 | 2711.6 | 1312.3 | 82.0 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 789 | 2710 | 2710.0 | 66.8 | 66.8 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
| 790 | 10839 | 2709.8 | 226.1 | 56.5 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 791 | 2703 | 2703.0 | 82.8 | 82.8 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 792 | 2702 | 2702.0 | 95.9 | 95.9 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 793 | 5401 | 2700.5 | 130.7 | 65.3 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 794 | 2697 | 2697.0 | 50.5 | 50.5 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
| 795 | 5387 | 2693.5 | 156.1 | 78.0 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 796 | 2693 | 2693.0 | 74.4 | 74.4 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 797 | 2692 | 2692.0 | 63.5 | 63.5 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
| 798 | 2692 | 2692.0 | 64.7 | 64.7 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 799 | 5368 | 2684.0 | 172.5 | 86.2 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
| 800 | 2684 | 2684.0 | 61.6 | 61.6 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
| 801 | 2684 | 2684.0 | 55.9 | 55.9 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
| 802 | 8037 | 2679.0 | 194.5 | 64.8 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 803 | 5353 | 2676.5 | 72.4 | 36.2 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 804 | 5353 | 2676.5 | 167.3 | 83.7 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 805 | 2671 | 2671.0 | 77.2 | 77.2 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 806 | 5338 | 2669.0 | 111.6 | 55.8 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 807 | 2668 | 2668.0 | 70.3 | 70.3 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 808 | 5330 | 2665.0 | 170.9 | 85.5 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 809 | 2662 | 2662.0 | 66.0 | 66.0 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 810 | 2660 | 2660.0 | 59.2 | 59.2 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 811 | 2659 | 2659.0 | 72.8 | 72.8 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 812 | 2658 | 2658.0 | 55.4 | 55.4 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 813 | 10620 | 2655.0 | 263.6 | 65.9 | GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 814 | 2652 | 2652.0 | 106.4 | 106.4 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 815 | 5295 | 2647.5 | 126.7 | 63.4 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
| 816 | 5294 | 2647.0 | 138.3 | 69.2 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 817 | 2642 | 2642.0 | 166.6 | 166.6 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | No |
| 818 | 2635 | 2635.0 | 107.5 | 107.5 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
| 819 | 2633 | 2633.0 | 86.6 | 86.6 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 820 | 5260 | 2630.0 | 153.8 | 76.9 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 821 | 2629 | 2629.0 | 70.9 | 70.9 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
| 822 | 2625 | 2625.0 | 56.7 | 56.7 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 823 | 7873 | 2624.3 | 204.5 | 68.2 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni Gabaldon | Bioinformatics | 2009 | 19505945 | Yes |
| 824 | 5248 | 2624.0 | 116.5 | 58.2 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 825 | 5243 | 2621.5 | 160.6 | 80.3 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
| 826 | 5242 | 2621.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O ARUNLAKSHANA, H O SCHILD | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 827 | 2621 | 2621.0 | 75.8 | 75.8 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 828 | 2616 | 2616.0 | 115.9 | 115.9 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 829 | 2615 | 2615.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 830 | 5227 | 2613.5 | 180.0 | 90.0 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 831 | 2613 | 2613.0 | 35.4 | 35.4 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 832 | 2607 | 2607.0 | 72.1 | 72.1 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 833 | 5209 | 2604.5 | 102.2 | 51.1 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 834 | 2603 | 2603.0 | 55.1 | 55.1 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 835 | 5201 | 2600.5 | 111.5 | 55.8 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
| 836 | 2598 | 2598.0 | 80.5 | 80.5 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 837 | 7790 | 2596.7 | 215.3 | 71.8 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 838 | 2595 | 2595.0 | 61.6 | 61.6 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 839 | 2593 | 2593.0 | 81.3 | 81.3 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
| 840 | 2592 | 2592.0 | 131.1 | 131.1 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | No |
| 841 | 2585 | 2585.0 | 73.2 | 73.2 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 842 | 10338 | 2584.5 | 217.8 | 54.5 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 843 | 2582 | 2582.0 | 69.1 | 69.1 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 844 | 2580 | 2580.0 | 61.3 | 61.3 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 845 | 5145 | 2572.5 | 139.1 | 69.5 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 846 | 2571 | 2571.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R PORTER | Biochem J | 1959 | 14434282 | Yes |
| 847 | 2570 | 2570.0 | 74.8 | 74.8 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 848 | 2569 | 2569.0 | 103.8 | 103.8 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 849 | 2569 | 2569.0 | 120.5 | 120.5 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
| 850 | 5130 | 2565.0 | 218.8 | 109.4 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 851 | 2564 | 2564.0 | 67.5 | 67.5 | TGFβ signalling in context. | Joan Massague | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
| 852 | 5119 | 2559.5 | 277.1 | 138.6 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 853 | 5116 | 2558.0 | 147.7 | 73.8 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 854 | 2558 | 2558.0 | 126.6 | 126.6 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S BOYDEN | J Exp Med | 1962 | 13872176 | Yes |
| 855 | 2556 | 2556.0 | 76.9 | 76.9 | A two process model of sleep regulation. | A A Borbely | Hum Neurobiol | 1982 | 7185792 | Yes |
| 856 | 2551 | 2551.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O SMITHIES | Biochem J | 1955 | 13276348 | Yes |
| 857 | 5102 | 2551.0 | 131.8 | 65.9 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 858 | 2548 | 2548.0 | 50.8 | 50.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 859 | 5087 | 2543.5 | 143.4 | 71.7 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 860 | 5083 | 2541.5 | 70.9 | 35.5 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H LOE, J SILNESS | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 861 | 5081 | 2540.5 | 133.0 | 66.5 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
| 862 | 2540 | 2540.0 | 80.3 | 80.3 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 863 | 5079 | 2539.5 | 121.7 | 60.9 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 864 | 2538 | 2538.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 865 | 2535 | 2535.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M FITTS | J Exp Psychol | 1954 | 13174710 | Yes |
| 866 | 2532 | 2532.0 | 82.9 | 82.9 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 867 | 5064 | 2532.0 | 149.8 | 74.9 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
| 868 | 5049 | 2524.5 | 130.7 | 65.3 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 869 | 5041 | 2520.5 | 162.5 | 81.2 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rossello-Mora | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 870 | 2519 | 2519.0 | 76.6 | 76.6 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
| 871 | 5038 | 2519.0 | 96.1 | 48.0 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
| 872 | 2519 | 2519.0 | 44.1 | 44.1 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
| 873 | 12570 | 2514.0 | 282.7 | 56.5 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 874 | 2513 | 2513.0 | 62.9 | 62.9 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 875 | 2513 | 2513.0 | 70.1 | 70.1 | Hazards of heavy metal contamination. | Lars Jarup | Br Med Bull | 2003 | 14757716 | No |
| 876 | 2513 | 2513.0 | 56.9 | 56.9 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
| 877 | 2512 | 2512.0 | 61.2 | 61.2 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 878 | 2512 | 2512.0 | 131.3 | 131.3 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
| 879 | 2510 | 2510.0 | 50.8 | 50.8 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 880 | 5013 | 2506.5 | 161.9 | 81.0 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 881 | 2503 | 2503.0 | 44.3 | 44.3 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
| 882 | 5001 | 2500.5 | 133.2 | 66.6 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
| 883 | 2495 | 2495.0 | 129.8 | 129.8 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 884 | 2494 | 2494.0 | 76.9 | 76.9 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
| 885 | 4985 | 2492.5 | 180.9 | 90.5 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 886 | 2492 | 2492.0 | 52.1 | 52.1 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
| 887 | 2492 | 2492.0 | 70.8 | 70.8 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 888 | 2491 | 2491.0 | 52.6 | 52.6 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
| 889 | 2490 | 2490.0 | 62.6 | 62.6 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 890 | 2488 | 2488.0 | 95.1 | 95.1 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 891 | 4972 | 2486.0 | 119.2 | 59.6 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 892 | 2485 | 2485.0 | 59.9 | 59.9 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
| 893 | 2484 | 2484.0 | 43.8 | 43.8 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 894 | 4963 | 2481.5 | 93.5 | 46.8 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
| 895 | 2476 | 2476.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S LENNOX | Virology | 1955 | 13267987 | Yes |
| 896 | 2475 | 2475.0 | 112.1 | 112.1 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 897 | 7424 | 2474.7 | 156.5 | 52.2 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
| 898 | 4949 | 2474.5 | 95.1 | 47.5 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
| 899 | 9897 | 2474.2 | 211.2 | 52.8 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 900 | 9885 | 2471.2 | 195.1 | 48.8 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 901 | 4940 | 2470.0 | 105.1 | 52.5 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 902 | 4938 | 2469.0 | 121.3 | 60.6 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
| 903 | 2469 | 2469.0 | 59.9 | 59.9 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
| 904 | 2467 | 2467.0 | 79.3 | 79.3 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 905 | 2465 | 2465.0 | 53.2 | 53.2 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 906 | 2465 | 2465.0 | 28.1 | 28.1 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T HIGUCHI | J Pharm Sci | 1963 | 14088963 | Yes |
| 907 | 2464 | 2464.0 | 47.3 | 47.3 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 908 | 2462 | 2462.0 | 58.8 | 58.8 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 909 | 2461 | 2461.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G BERTANI | J Bacteriol | 1951 | 14888646 | Yes |
| 910 | 2455 | 2455.0 | 64.4 | 64.4 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
| 911 | 2455 | 2455.0 | 62.4 | 62.4 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
| 912 | 2451 | 2451.0 | 65.0 | 65.0 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 913 | 4899 | 2449.5 | 105.9 | 53.0 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
| 914 | 2447 | 2447.0 | 53.8 | 53.8 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 915 | 2447 | 2447.0 | 62.9 | 62.9 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 916 | 7340 | 2446.7 | 222.9 | 74.3 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 917 | 7337 | 2445.7 | 289.1 | 96.4 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
| 918 | 2444 | 2444.0 | 57.8 | 57.8 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 919 | 4885 | 2442.5 | 136.3 | 68.2 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
| 920 | 2441 | 2441.0 | 62.1 | 62.1 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 921 | 4877 | 2438.5 | 112.6 | 56.3 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 922 | 2437 | 2437.0 | 74.6 | 74.6 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 923 | 2435 | 2435.0 | 67.7 | 67.7 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 924 | 4863 | 2431.5 | 109.2 | 54.6 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
| 925 | 4859 | 2429.5 | 175.0 | 87.5 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 926 | 19434 | 2429.2 | 743.3 | 92.9 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver Glockner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 927 | 4851 | 2425.5 | 169.4 | 84.7 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
| 928 | 2425 | 2425.0 | 51.9 | 51.9 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 929 | 4844 | 2422.0 | 126.5 | 63.2 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 930 | 9685 | 2421.2 | 451.2 | 112.8 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 931 | 2421 | 2421.0 | 49.1 | 49.1 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
| 932 | 2419 | 2419.0 | 55.8 | 55.8 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 933 | 2419 | 2419.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F HUXLEY | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 934 | 4836 | 2418.0 | 97.3 | 48.6 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
| 935 | 2417 | 2417.0 | 54.7 | 54.7 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
| 936 | 2417 | 2417.0 | 49.5 | 49.5 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
| 937 | 2412 | 2412.0 | 80.4 | 80.4 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jobsis | Science | 1977 | 929199 | Yes |
| 938 | 2412 | 2412.0 | 128.5 | 128.5 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 939 | 4821 | 2410.5 | 134.5 | 67.2 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
| 940 | 2410 | 2410.0 | 62.7 | 62.7 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 941 | 4818 | 2409.0 | 90.9 | 45.5 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massague | Cell | 2003 | 12809600 | No |
| 942 | 4817 | 2408.5 | 175.4 | 87.7 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
| 943 | 2405 | 2405.0 | 74.6 | 74.6 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 944 | 7199 | 2399.7 | 69.4 | 23.1 | On The Nature Of Allosteric Transitions: A Plausible Model. | J MONOD, J WYMAN, J P CHANGEUX | J Mol Biol | 1965 | 14343300 | Yes |
| 945 | 2399 | 2399.0 | 48.2 | 48.2 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 946 | 4796 | 2398.0 | 124.7 | 62.4 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 947 | 4793 | 2396.5 | 117.9 | 59.0 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
| 948 | 2394 | 2394.0 | 92.2 | 92.2 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | No |
| 949 | 4782 | 2391.0 | 139.1 | 69.5 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 950 | 2390 | 2390.0 | 56.1 | 56.1 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
| 951 | 7164 | 2388.0 | 203.6 | 67.9 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
| 952 | 4771 | 2385.5 | 118.9 | 59.5 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 953 | 4765 | 2382.5 | 103.0 | 51.5 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 954 | 2382 | 2382.0 | 141.4 | 141.4 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 955 | 2382 | 2382.0 | 97.8 | 97.8 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 956 | 7141 | 2380.3 | 193.0 | 64.3 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 957 | 4757 | 2378.5 | 89.1 | 44.5 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 958 | 4748 | 2374.0 | 96.4 | 48.2 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 959 | 9479 | 2369.8 | 217.7 | 54.4 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 960 | 7109 | 2369.7 | 208.2 | 69.4 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 961 | 2368 | 2368.0 | 45.5 | 45.5 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 962 | 2366 | 2366.0 | 78.6 | 78.6 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 963 | 2364 | 2364.0 | 50.7 | 50.7 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 964 | 2359 | 2359.0 | 42.8 | 42.8 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | No |
| 965 | 2357 | 2357.0 | 40.1 | 40.1 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 966 | 2355 | 2355.0 | 91.3 | 91.3 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 967 | 2354 | 2354.0 | 57.8 | 57.8 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 968 | 7058 | 2352.7 | 249.8 | 83.3 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 969 | 4704 | 2352.0 | 117.6 | 58.8 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 970 | 2351 | 2351.0 | 51.7 | 51.7 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
| 971 | 4700 | 2350.0 | 77.4 | 38.7 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 972 | 4695 | 2347.5 | 116.0 | 58.0 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 973 | 2346 | 2346.0 | 68.8 | 68.8 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
| 974 | 4690 | 2345.0 | 88.1 | 44.0 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 975 | 2342 | 2342.0 | 56.1 | 56.1 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
| 976 | 2341 | 2341.0 | 65.7 | 65.7 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 977 | 2341 | 2341.0 | 43.0 | 43.0 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 978 | 4679 | 2339.5 | 153.2 | 76.6 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
| 979 | 4679 | 2339.5 | 245.5 | 122.8 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 980 | 4671 | 2335.5 | 102.2 | 51.1 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 981 | 4669 | 2334.5 | 191.8 | 95.9 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 982 | 2334 | 2334.0 | 52.4 | 52.4 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 983 | 2334 | 2334.0 | 72.0 | 72.0 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
| 984 | 4665 | 2332.5 | 110.7 | 55.4 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 985 | 4664 | 2332.0 | 114.9 | 57.5 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 986 | 2332 | 2332.0 | 84.0 | 84.0 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 987 | 2331 | 2331.0 | 62.2 | 62.2 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 988 | 2330 | 2330.0 | 101.5 | 101.5 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | No |
| 989 | 2329 | 2329.0 | 66.6 | 66.6 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 990 | 2327 | 2327.0 | 48.6 | 48.6 | Theta oscillations in the hippocampus. | Gyorgy Buzsaki | Neuron | 2002 | 11832222 | No |
| 991 | 2326 | 2326.0 | 71.7 | 71.7 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
| 992 | 2325 | 2325.0 | 64.4 | 64.4 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
| 993 | 4648 | 2324.0 | 76.8 | 38.4 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 994 | 2321 | 2321.0 | 56.9 | 56.9 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
| 995 | 2320 | 2320.0 | 85.9 | 85.9 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 996 | 6960 | 2320.0 | 139.4 | 46.5 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 997 | 2320 | 2320.0 | 56.1 | 56.1 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
| 998 | 4638 | 2319.0 | 164.8 | 82.4 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
| 999 | 4637 | 2318.5 | 128.0 | 64.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 1000 | 2313 | 2313.0 | 69.3 | 69.3 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 1001 | 4614 | 2307.0 | 88.9 | 44.5 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 1002 | 6919 | 2306.3 | 265.6 | 88.5 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 1003 | 4609 | 2304.5 | 69.2 | 34.6 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 1004 | 4609 | 2304.5 | 162.7 | 81.3 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
| 1005 | 2304 | 2304.0 | 49.4 | 49.4 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
| 1006 | 2302 | 2302.0 | 56.5 | 56.5 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
| 1007 | 4603 | 2301.5 | 190.2 | 95.1 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1008 | 4603 | 2301.5 | 201.4 | 100.7 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
| 1009 | 4598 | 2299.0 | 144.6 | 72.3 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 1010 | 4597 | 2298.5 | 109.3 | 54.6 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 1011 | 2297 | 2297.0 | 61.0 | 61.0 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1012 | 2296 | 2296.0 | 47.6 | 47.6 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
| 1013 | 6888 | 2296.0 | 157.1 | 52.4 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1014 | 4590 | 2295.0 | 84.8 | 42.4 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1015 | 4587 | 2293.5 | 110.4 | 55.2 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
| 1016 | 2293 | 2293.0 | 92.0 | 92.0 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
| 1017 | 4583 | 2291.5 | 129.2 | 64.6 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 1018 | 2291 | 2291.0 | 69.3 | 69.3 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 1019 | 2290 | 2290.0 | 68.7 | 68.7 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 1020 | 2290 | 2290.0 | 54.3 | 54.3 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1021 | 2290 | 2290.0 | 67.0 | 67.0 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 1022 | 2289 | 2289.0 | 77.7 | 77.7 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 1023 | 4569 | 2284.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B SCOVILLE, B MILNER | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1024 | 2284 | 2284.0 | 75.7 | 75.7 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
| 1025 | 2284 | 2284.0 | 45.2 | 45.2 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 1026 | 2284 | 2284.0 | 55.0 | 55.0 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1027 | 2284 | 2284.0 | 60.6 | 60.6 | Hybrid porous solids: past, present, future. | Gerard Ferey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 1028 | 2284 | 2284.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H PENNES | J Appl Physiol | 1948 | 18887578 | Yes |
| 1029 | 2283 | 2283.0 | 56.7 | 56.7 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1030 | 2281 | 2281.0 | 56.5 | 56.5 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
| 1031 | 9124 | 2281.0 | 291.1 | 72.8 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
| 1032 | 4557 | 2278.5 | 126.0 | 63.0 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 1033 | 25052 | 2277.5 | 600.7 | 54.6 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1034 | 2277 | 2277.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A CLAUSS | Acta Haematol | 1957 | 13434757 | Yes |
| 1035 | 4552 | 2276.0 | 86.7 | 43.4 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 1036 | 4545 | 2272.5 | 121.4 | 60.7 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1037 | 2270 | 2270.0 | 50.1 | 50.1 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 1038 | 2269 | 2269.0 | 63.4 | 63.4 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
| 1039 | 2268 | 2268.0 | 51.4 | 51.4 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
| 1040 | 4532 | 2266.0 | 89.2 | 44.6 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 1041 | 2264 | 2264.0 | 73.6 | 73.6 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 1042 | 2263 | 2263.0 | 48.3 | 48.3 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
| 1043 | 2261 | 2261.0 | 61.6 | 61.6 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
| 1044 | 2260 | 2260.0 | 111.4 | 111.4 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 1045 | 2259 | 2259.0 | 138.4 | 138.4 | Application of a microtechnique to viral serological investigations. | J L SEVER | J Immunol | 1962 | 13910995 | Yes |
| 1046 | 2259 | 2259.0 | 45.5 | 45.5 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 1047 | 2256 | 2256.0 | 52.8 | 52.8 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
| 1048 | 4508 | 2254.0 | 38.2 | 19.1 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 1049 | 4507 | 2253.5 | 128.5 | 64.2 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 1050 | 6760 | 2253.3 | 210.0 | 70.0 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman, | Hepatology | 2011 | 21374666 | No |
| 1051 | 2253 | 2253.0 | 52.9 | 52.9 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
| 1052 | 2251 | 2251.0 | 47.9 | 47.9 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 1053 | 2251 | 2251.0 | 64.7 | 64.7 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
| 1054 | 4499 | 2249.5 | 102.3 | 51.1 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 1055 | 2248 | 2248.0 | 57.6 | 57.6 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 1056 | 2247 | 2247.0 | 60.9 | 60.9 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 1057 | 2246 | 2246.0 | 116.0 | 116.0 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 1058 | 2246 | 2246.0 | 54.9 | 54.9 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 1059 | 4492 | 2246.0 | 102.6 | 51.3 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 1060 | 2245 | 2245.0 | 76.7 | 76.7 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 1061 | 2244 | 2244.0 | 95.7 | 95.7 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1062 | 2243 | 2243.0 | 48.7 | 48.7 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 1063 | 2242 | 2242.0 | 49.0 | 49.0 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
| 1064 | 13438 | 2239.7 | 296.0 | 49.3 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1065 | 2238 | 2238.0 | 52.2 | 52.2 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1066 | 4475 | 2237.5 | 98.9 | 49.5 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 1067 | 2237 | 2237.0 | 54.1 | 54.1 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gokhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1068 | 4471 | 2235.5 | 140.0 | 70.0 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
| 1069 | 2235 | 2235.0 | 65.6 | 65.6 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 1070 | 8936 | 2234.0 | 343.6 | 85.9 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramon Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1071 | 2230 | 2230.0 | 111.5 | 111.5 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
| 1072 | 4457 | 2228.5 | 93.8 | 46.9 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1073 | 2228 | 2228.0 | 52.2 | 52.2 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 1074 | 6679 | 2226.3 | 179.7 | 59.9 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdottir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1075 | 4452 | 2226.0 | 97.9 | 49.0 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
| 1076 | 2226 | 2226.0 | 78.2 | 78.2 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | No |
| 1077 | 4449 | 2224.5 | 120.1 | 60.0 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 1078 | 2222 | 2222.0 | 72.3 | 72.3 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1079 | 2220 | 2220.0 | 61.2 | 61.2 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 1080 | 2220 | 2220.0 | 94.3 | 94.3 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
| 1081 | 2219 | 2219.0 | 76.9 | 76.9 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 1082 | 2219 | 2219.0 | 39.6 | 39.6 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
| 1083 | 2216 | 2216.0 | 91.6 | 91.6 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1084 | 4432 | 2216.0 | 94.1 | 47.0 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1085 | 4428 | 2214.0 | 83.7 | 41.9 | Network biology: understanding the cell's functional organization. | Albert-Laszlo Barabasi, Zoltan N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
| 1086 | 2211 | 2211.0 | 78.7 | 78.7 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1087 | 2210 | 2210.0 | 59.3 | 59.3 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1088 | 2209 | 2209.0 | 67.5 | 67.5 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 1089 | 4412 | 2206.0 | 167.9 | 84.0 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 1090 | 2205 | 2205.0 | 56.4 | 56.4 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 1091 | 2205 | 2205.0 | 82.8 | 82.8 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
| 1092 | 4408 | 2204.0 | 154.2 | 77.1 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1093 | 2204 | 2204.0 | 48.2 | 48.2 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 1094 | 2202 | 2202.0 | 48.8 | 48.8 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
| 1095 | 2202 | 2202.0 | 51.3 | 51.3 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
| 1096 | 4400 | 2200.0 | 94.2 | 47.1 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 1097 | 6584 | 2194.7 | 188.8 | 62.9 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1098 | 6583 | 2194.3 | 166.2 | 55.4 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1099 | 6582 | 2194.0 | 118.8 | 39.6 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1100 | 4386 | 2193.0 | 80.4 | 40.2 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
| 1101 | 4383 | 2191.5 | 233.5 | 116.8 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 1102 | 2191 | 2191.0 | 69.7 | 69.7 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
| 1103 | 4381 | 2190.5 | 147.4 | 73.7 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1104 | 4379 | 2189.5 | 116.9 | 58.5 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | No |
| 1105 | 2189 | 2189.0 | 46.5 | 46.5 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
| 1106 | 2187 | 2187.0 | 69.0 | 69.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Loe | J Periodontol | 1967 | 5237684 | Yes |
| 1107 | 2185 | 2185.0 | 51.9 | 51.9 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1108 | 17458 | 2182.2 | 487.5 | 60.9 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1109 | 2182 | 2182.0 | 85.4 | 85.4 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1110 | 4363 | 2181.5 | 132.4 | 66.2 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
| 1111 | 2180 | 2180.0 | 66.6 | 66.6 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1112 | 6540 | 2180.0 | 210.3 | 70.1 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 1113 | 8718 | 2179.5 | 282.1 | 70.5 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1114 | 4358 | 2179.0 | 170.1 | 85.0 | The amyloid hypothesis of Alzheimer's disease at 25Â years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
| 1115 | 2176 | 2176.0 | 58.8 | 58.8 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
| 1116 | 8703 | 2175.8 | 201.6 | 50.4 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1117 | 4346 | 2173.0 | 103.3 | 51.6 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1118 | 2172 | 2172.0 | 50.8 | 50.8 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 1119 | 2170 | 2170.0 | 64.7 | 64.7 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1120 | 4339 | 2169.5 | 82.5 | 41.2 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
| 1121 | 4339 | 2169.5 | 98.9 | 49.5 | Neuronal oscillations in cortical networks. | Gyorgy Buzsaki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1122 | 2169 | 2169.0 | 59.1 | 59.1 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
| 1123 | 4337 | 2168.5 | 160.8 | 80.4 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
| 1124 | 2167 | 2167.0 | 41.5 | 41.5 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 1125 | 4330 | 2165.0 | 190.0 | 95.0 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1126 | 4330 | 2165.0 | 94.5 | 47.2 | Liver fibrosis. | Ramon Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
| 1127 | 2164 | 2164.0 | 49.5 | 49.5 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
| 1128 | 8648 | 2162.0 | 204.5 | 51.1 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1129 | 2161 | 2161.0 | 66.6 | 66.6 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
| 1130 | 4319 | 2159.5 | 101.1 | 50.5 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
| 1131 | 2159 | 2159.0 | 42.5 | 42.5 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
| 1132 | 2157 | 2157.0 | 49.7 | 49.7 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1133 | 2155 | 2155.0 | 40.6 | 40.6 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
| 1134 | 2154 | 2154.0 | 42.7 | 42.7 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 1135 | 2154 | 2154.0 | 58.9 | 58.9 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
| 1136 | 4306 | 2153.0 | 106.7 | 53.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
| 1137 | 2153 | 2153.0 | 30.5 | 30.5 | Sedimentation Studies Of The Size And Shape Of Dna. | F W STUDIER | J Mol Biol | 1965 | 14290352 | Yes |
| 1138 | 4304 | 2152.0 | 104.3 | 52.1 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
| 1139 | 2151 | 2151.0 | 64.7 | 64.7 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1140 | 2151 | 2151.0 | 54.7 | 54.7 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
| 1141 | 10754 | 2150.8 | 332.5 | 66.5 | The hallmarks of aging. | Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
| 1142 | 2150 | 2150.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O WARBURG | Science | 1956 | 13351639 | Yes |
| 1143 | 6449 | 2149.7 | 205.2 | 68.4 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1144 | 4295 | 2147.5 | 123.7 | 61.9 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1145 | 4294 | 2147.0 | 121.9 | 61.0 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
| 1146 | 6439 | 2146.3 | 129.1 | 43.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1147 | 2146 | 2146.0 | 41.2 | 41.2 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
| 1148 | 2146 | 2146.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z DISCHE | J Biol Chem | 1947 | 20281638 | Yes |
| 1149 | 4292 | 2146.0 | 157.0 | 78.5 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | No |
| 1150 | 6436 | 2145.3 | 145.9 | 48.6 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wuthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1151 | 2144 | 2144.0 | 44.0 | 44.0 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1152 | 4288 | 2144.0 | 35.5 | 17.8 | Genetic regulatory mechanisms in the synthesis of proteins. | F JACOB, J MONOD | J Mol Biol | 1961 | 13718526 | Yes |
| 1153 | 6430 | 2143.3 | 204.0 | 68.0 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
| 1154 | 4286 | 2143.0 | 71.0 | 35.5 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H VENABLE, R COGGESHALL | J Cell Biol | 1965 | 14287192 | Yes |
| 1155 | 4280 | 2140.0 | 180.7 | 90.3 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | No |
| 1156 | 2139 | 2139.0 | 41.0 | 41.0 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
| 1157 | 6416 | 2138.7 | 266.9 | 89.0 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1158 | 4277 | 2138.5 | 181.7 | 90.8 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1159 | 2138 | 2138.0 | 64.2 | 64.2 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1160 | 2138 | 2138.0 | 41.8 | 41.8 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
| 1161 | 2137 | 2137.0 | 50.5 | 50.5 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1162 | 8544 | 2136.0 | 315.8 | 79.0 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerstrom | Br J Addict | 1991 | 1932883 | Yes |
| 1163 | 4272 | 2136.0 | 110.8 | 55.4 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
| 1164 | 4272 | 2136.0 | 85.2 | 42.6 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
| 1165 | 2134 | 2134.0 | 81.0 | 81.0 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 1166 | 2132 | 2132.0 | 44.7 | 44.7 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
| 1167 | 2130 | 2130.0 | 42.9 | 42.9 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 1168 | 4257 | 2128.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F BEERS, I W SIZER | J Biol Chem | 1952 | 14938361 | Yes |
| 1169 | 2128 | 2128.0 | 65.3 | 65.3 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1170 | 4255 | 2127.5 | 121.7 | 60.9 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 1171 | 2126 | 2126.0 | 65.7 | 65.7 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1172 | 2125 | 2125.0 | 44.1 | 44.1 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 1173 | 4250 | 2125.0 | 82.4 | 41.2 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 1174 | 14871 | 2124.4 | 419.6 | 59.9 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1175 | 14870 | 2124.3 | 320.8 | 45.8 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1176 | 6372 | 2124.0 | 205.6 | 68.5 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
| 1177 | 2121 | 2121.0 | 34.3 | 34.3 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D AMINOFF | Biochem J | 1961 | 13860975 | Yes |
| 1178 | 2119 | 2119.0 | 83.5 | 83.5 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 1179 | 4237 | 2118.5 | 119.5 | 59.8 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 1180 | 2118 | 2118.0 | 98.6 | 98.6 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1181 | 4232 | 2116.0 | 82.3 | 41.1 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1182 | 2116 | 2116.0 | 78.9 | 78.9 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 1183 | 4229 | 2114.5 | 117.8 | 58.9 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1184 | 2113 | 2113.0 | 73.4 | 73.4 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
| 1185 | 4226 | 2113.0 | 141.3 | 70.7 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
| 1186 | 2112 | 2112.0 | 60.4 | 60.4 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
| 1187 | 4223 | 2111.5 | 105.9 | 53.0 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1188 | 2111 | 2111.0 | 49.3 | 49.3 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1189 | 2111 | 2111.0 | 47.2 | 47.2 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
| 1190 | 6331 | 2110.3 | 182.3 | 60.8 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1191 | 4220 | 2110.0 | 132.6 | 66.3 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
| 1192 | 4219 | 2109.5 | 279.7 | 139.8 | WHO Declares COVID-19 a Pandemic. | Domenico Cucinotta, Maurizio Vanelli | Acta Biomed | 2020 | 32191675 | Yes |
| 1193 | 4215 | 2107.5 | 151.4 | 75.7 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1194 | 4213 | 2106.5 | 149.1 | 74.5 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1195 | 2105 | 2105.0 | 40.6 | 40.6 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
| 1196 | 2104 | 2104.0 | 47.2 | 47.2 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
| 1197 | 4207 | 2103.5 | 80.4 | 40.2 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
| 1198 | 4194 | 2097.0 | 89.0 | 44.5 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1199 | 4194 | 2097.0 | 226.6 | 113.3 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1200 | 8385 | 2096.2 | 268.6 | 67.2 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1201 | 14663 | 2094.7 | 321.8 | 46.0 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1202 | 2094 | 2094.0 | 50.4 | 50.4 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
| 1203 | 16752 | 2094.0 | 392.8 | 49.1 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1204 | 4188 | 2094.0 | 146.6 | 73.3 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1205 | 2094 | 2094.0 | 65.9 | 65.9 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 1206 | 2093 | 2093.0 | 40.2 | 40.2 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
| 1207 | 2093 | 2093.0 | 74.5 | 74.5 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1208 | 2093 | 2093.0 | 42.5 | 42.5 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 1209 | 2089 | 2089.0 | 56.5 | 56.5 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
| 1210 | 2089 | 2089.0 | 40.1 | 40.1 | Method For Assay Of Intestinal Disaccharidases. | A DAHLQVIST | Anal Biochem | 1964 | 14106916 | Yes |
| 1211 | 2089 | 2089.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C TOLMAN | Psychol Rev | 1948 | 18870876 | Yes |
| 1212 | 2088 | 2088.0 | 43.2 | 43.2 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
| 1213 | 4175 | 2087.5 | 99.6 | 49.8 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1214 | 2087 | 2087.0 | 52.5 | 52.5 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
| 1215 | 2087 | 2087.0 | 47.1 | 47.1 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1216 | 2086 | 2086.0 | 39.4 | 39.4 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
| 1217 | 2085 | 2085.0 | 38.5 | 38.5 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
| 1218 | 2082 | 2082.0 | 48.7 | 48.7 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1219 | 2080 | 2080.0 | 59.3 | 59.3 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1220 | 2079 | 2079.0 | 64.8 | 64.8 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1221 | 4157 | 2078.5 | 110.7 | 55.4 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 1222 | 6235 | 2078.3 | 208.7 | 69.6 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1223 | 2076 | 2076.0 | 57.2 | 57.2 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
| 1224 | 2076 | 2076.0 | 38.9 | 38.9 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
| 1225 | 4151 | 2075.5 | 139.9 | 70.0 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | Yes |
| 1226 | 2072 | 2072.0 | 36.3 | 36.3 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C SKOU | Physiol Rev | 1965 | 14337569 | No |
| 1227 | 2071 | 2071.0 | 42.3 | 42.3 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 1228 | 2071 | 2071.0 | 63.3 | 63.3 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1229 | 2068 | 2068.0 | 51.7 | 51.7 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
| 1230 | 2066 | 2066.0 | 51.5 | 51.5 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1231 | 4132 | 2066.0 | 100.4 | 50.2 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
| 1232 | 6195 | 2065.0 | 229.4 | 76.5 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1233 | 6191 | 2063.7 | 197.5 | 65.8 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
| 1234 | 4127 | 2063.5 | 126.7 | 63.4 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 1235 | 4126 | 2063.0 | 95.7 | 47.9 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1236 | 2063 | 2063.0 | 46.2 | 46.2 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
| 1237 | 4125 | 2062.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R DULBECCO, M VOGT | J Exp Med | 1954 | 13130792 | Yes |
| 1238 | 4124 | 2062.0 | 85.6 | 42.8 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1239 | 2061 | 2061.0 | 46.5 | 46.5 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1240 | 4120 | 2060.0 | 88.9 | 44.5 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1241 | 2060 | 2060.0 | 18.6 | 18.6 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W CLELAND | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1242 | 4116 | 2058.0 | 109.9 | 55.0 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1243 | 2058 | 2058.0 | 79.2 | 79.2 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | No |
| 1244 | 2056 | 2056.0 | 47.4 | 47.4 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 1245 | 2055 | 2055.0 | 34.6 | 34.6 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
| 1246 | 4109 | 2054.5 | 117.8 | 58.9 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1247 | 2054 | 2054.0 | 84.1 | 84.1 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1248 | 2054 | 2054.0 | 101.1 | 101.1 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V NEEL | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1249 | 2053 | 2053.0 | 23.9 | 23.9 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W LITTLEFIELD | Science | 1964 | 14168277 | Yes |
| 1250 | 8209 | 2052.2 | 224.5 | 56.1 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1251 | 2051 | 2051.0 | 67.5 | 67.5 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1252 | 4100 | 2050.0 | 78.7 | 39.4 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelieres | J Microsc | 2006 | 17210054 | Yes |
| 1253 | 4099 | 2049.5 | 125.4 | 62.7 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1254 | 4093 | 2046.5 | 110.1 | 55.0 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1255 | 2046 | 2046.0 | 58.7 | 58.7 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 1256 | 2046 | 2046.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A SHOLL | J Anat | 1953 | 13117757 | Yes |
| 1257 | 2046 | 2046.0 | 53.0 | 53.0 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1258 | 2044 | 2044.0 | 57.1 | 57.1 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1259 | 2044 | 2044.0 | 55.5 | 55.5 | Introduction and General Overview of Cyclodextrin Chemistry. | Jozsef Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1260 | 2044 | 2044.0 | 34.7 | 34.7 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
| 1261 | 4084 | 2042.0 | 90.0 | 45.0 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
| 1262 | 18342 | 2038.0 | 567.3 | 63.0 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
| 1263 | 4074 | 2037.0 | 139.3 | 69.7 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1264 | 4074 | 2037.0 | 92.1 | 46.0 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1265 | 4073 | 2036.5 | 101.9 | 51.0 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1266 | 2036 | 2036.0 | 84.3 | 84.3 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1267 | 2036 | 2036.0 | 58.4 | 58.4 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1268 | 2035 | 2035.0 | 63.1 | 63.1 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1269 | 2034 | 2034.0 | 51.8 | 51.8 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
| 1270 | 2034 | 2034.0 | 72.0 | 72.0 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1271 | 4065 | 2032.5 | 97.7 | 48.9 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1272 | 2032 | 2032.0 | 47.2 | 47.2 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 1273 | 6095 | 2031.7 | 153.5 | 51.2 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1274 | 14200 | 2028.6 | 376.2 | 53.7 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1275 | 2026 | 2026.0 | 50.6 | 50.6 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1276 | 2026 | 2026.0 | 59.8 | 59.8 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1277 | 2025 | 2025.0 | 36.8 | 36.8 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1278 | 2025 | 2025.0 | 50.4 | 50.4 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
| 1279 | 6075 | 2025.0 | 248.5 | 82.8 | Shedding light on the cell biology of extracellular vesicles. | Guillaume van Niel, Gisela D'Angelo, Graca Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | No |
| 1280 | 2024 | 2024.0 | 59.4 | 59.4 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
| 1281 | 2023 | 2023.0 | 51.4 | 51.4 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1282 | 2023 | 2023.0 | 41.5 | 41.5 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 1283 | 2023 | 2023.0 | 63.5 | 63.5 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
| 1284 | 2021 | 2021.0 | 88.5 | 88.5 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1285 | 2021 | 2021.0 | 51.8 | 51.8 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1286 | 8083 | 2020.8 | 186.7 | 46.7 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1287 | 2020 | 2020.0 | 70.0 | 70.0 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
| 1288 | 4038 | 2019.0 | 158.6 | 79.3 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1289 | 4038 | 2019.0 | 98.1 | 49.0 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 1290 | 2019 | 2019.0 | 45.3 | 45.3 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1291 | 2019 | 2019.0 | 38.9 | 38.9 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 1292 | 2018 | 2018.0 | 42.8 | 42.8 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1293 | 2018 | 2018.0 | 37.9 | 37.9 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 1294 | 4036 | 2018.0 | 98.8 | 49.4 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1295 | 4033 | 2016.5 | 78.0 | 39.0 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1296 | 6043 | 2014.3 | 107.5 | 35.8 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1297 | 2014 | 2014.0 | 43.5 | 43.5 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
| 1298 | 4028 | 2014.0 | 85.3 | 42.6 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 1299 | 2014 | 2014.0 | 39.7 | 39.7 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
| 1300 | 2014 | 2014.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1301 | 2013 | 2013.0 | 76.7 | 76.7 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1302 | 4025 | 2012.5 | 102.1 | 51.0 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1303 | 4024 | 2012.0 | 91.3 | 45.6 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 1304 | 4023 | 2011.5 | 176.0 | 88.0 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 1305 | 2011 | 2011.0 | 41.0 | 41.0 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1306 | 2011 | 2011.0 | 74.4 | 74.4 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
| 1307 | 4020 | 2010.0 | 86.6 | 43.3 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1308 | 4015 | 2007.5 | 121.5 | 60.8 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
| 1309 | 4013 | 2006.5 | 121.6 | 60.8 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1310 | 2006 | 2006.0 | 43.6 | 43.6 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1311 | 4011 | 2005.5 | 117.5 | 58.8 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1312 | 4007 | 2003.5 | 138.1 | 69.0 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1313 | 2003 | 2003.0 | 54.8 | 54.8 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1314 | 2003 | 2003.0 | 34.6 | 34.6 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 1315 | 2003 | 2003.0 | 43.3 | 43.3 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
| 1316 | 2002 | 2002.0 | 22.7 | 22.7 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1317 | 2002 | 2002.0 | 51.7 | 51.7 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1318 | 4003 | 2001.5 | 111.0 | 55.5 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
| 1319 | 5998 | 1999.3 | 260.4 | 86.8 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1320 | 3996 | 1998.0 | 107.8 | 53.9 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
| 1321 | 3995 | 1997.5 | 89.7 | 44.9 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schuttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1322 | 11982 | 1997.0 | 272.1 | 45.4 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1323 | 1996 | 1996.0 | 59.1 | 59.1 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1324 | 1996 | 1996.0 | 52.4 | 52.4 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
| 1325 | 7982 | 1995.5 | 308.6 | 77.2 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1326 | 3990 | 1995.0 | 93.9 | 47.0 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1327 | 7978 | 1994.5 | 266.0 | 66.5 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
| 1328 | 11965 | 1994.2 | 340.1 | 56.7 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1329 | 1994 | 1994.0 | 52.6 | 52.6 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
| 1330 | 1994 | 1994.0 | 40.4 | 40.4 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 1331 | 5980 | 1993.3 | 171.7 | 57.2 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 1332 | 11959 | 1993.2 | 339.3 | 56.6 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1333 | 3986 | 1993.0 | 112.1 | 56.0 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1334 | 1992 | 1992.0 | 43.7 | 43.7 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1335 | 1992 | 1992.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1336 | 9959 | 1991.8 | 225.3 | 45.1 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1337 | 3983 | 1991.5 | 102.6 | 51.3 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
| 1338 | 1990 | 1990.0 | 59.1 | 59.1 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1339 | 1990 | 1990.0 | 51.0 | 51.0 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
| 1340 | 1988 | 1988.0 | 39.9 | 39.9 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1341 | 7951 | 1987.8 | 355.6 | 88.9 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 1342 | 3975 | 1987.5 | 96.4 | 48.2 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
| 1343 | 1986 | 1986.0 | 41.6 | 41.6 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1344 | 1986 | 1986.0 | 56.0 | 56.0 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
| 1345 | 3969 | 1984.5 | 59.6 | 29.8 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R MORRISON, L M SMITH | J Lipid Res | 1964 | 14221106 | Yes |
| 1346 | 1983 | 1983.0 | 16.0 | 16.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1347 | 3966 | 1983.0 | 106.4 | 53.2 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1348 | 3962 | 1981.0 | 132.9 | 66.5 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
| 1349 | 1981 | 1981.0 | 48.4 | 48.4 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
| 1350 | 1980 | 1980.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R STEELE | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1351 | 5940 | 1980.0 | 340.7 | 113.6 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
| 1352 | 1979 | 1979.0 | 70.8 | 70.8 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
| 1353 | 1979 | 1979.0 | 39.0 | 39.0 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
| 1354 | 3956 | 1978.0 | 94.5 | 47.2 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 1355 | 1975 | 1975.0 | 48.6 | 48.6 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1356 | 3948 | 1974.0 | 141.0 | 70.5 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1357 | 1974 | 1974.0 | 69.7 | 69.7 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | No |
| 1358 | 1974 | 1974.0 | 177.5 | 177.5 | Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. | Brent R Stockwell | Cell | 2022 | 35803244 | No |
| 1359 | 1973 | 1973.0 | 66.7 | 66.7 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1360 | 1972 | 1972.0 | 38.7 | 38.7 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1361 | 13804 | 1972.0 | 392.2 | 56.0 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | Lancet | 2007 | 18064739 | Yes |
| 1362 | 3943 | 1971.5 | 79.9 | 40.0 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
| 1363 | 5914 | 1971.3 | 194.2 | 64.7 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1364 | 1971 | 1971.0 | 55.2 | 55.2 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
| 1365 | 1971 | 1971.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B WOOLF | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1366 | 1971 | 1971.0 | 45.9 | 45.9 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
| 1367 | 3941 | 1970.5 | 86.3 | 43.1 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1368 | 3941 | 1970.5 | 122.3 | 61.1 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
| 1369 | 5911 | 1970.3 | 148.7 | 49.6 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1370 | 1970 | 1970.0 | 51.8 | 51.8 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 1371 | 3937 | 1968.5 | 73.6 | 36.8 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
| 1372 | 1968 | 1968.0 | 57.6 | 57.6 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
| 1373 | 1968 | 1968.0 | 50.9 | 50.9 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
| 1374 | 3934 | 1967.0 | 126.2 | 63.1 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1375 | 1967 | 1967.0 | 44.7 | 44.7 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1376 | 1966 | 1966.0 | 57.0 | 57.0 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 1377 | 3930 | 1965.0 | 77.1 | 38.5 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1378 | 1965 | 1965.0 | 62.0 | 62.0 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1379 | 1963 | 1963.0 | 63.4 | 63.4 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
| 1380 | 1962 | 1962.0 | 55.7 | 55.7 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
| 1381 | 3923 | 1961.5 | 279.0 | 139.5 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | No |
| 1382 | 1961 | 1961.0 | 42.5 | 42.5 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
| 1383 | 1961 | 1961.0 | 73.9 | 73.9 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | No |
| 1384 | 1960 | 1960.0 | 76.1 | 76.1 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1385 | 1960 | 1960.0 | 40.3 | 40.3 | The etiology of chondromalacia patellae. | R E OUTERBRIDGE | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1386 | 1959 | 1959.0 | 57.4 | 57.4 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1387 | 3916 | 1958.0 | 84.7 | 42.4 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1388 | 1956 | 1956.0 | 55.3 | 55.3 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1389 | 1955 | 1955.0 | 70.6 | 70.6 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1390 | 1955 | 1955.0 | 42.0 | 42.0 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
| 1391 | 7805 | 1951.2 | 324.6 | 81.2 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1392 | 1951 | 1951.0 | 54.2 | 54.2 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
| 1393 | 1950 | 1950.0 | 64.1 | 64.1 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
| 1394 | 3900 | 1950.0 | 65.5 | 32.8 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1395 | 1950 | 1950.0 | 64.5 | 64.5 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1396 | 1950 | 1950.0 | 57.5 | 57.5 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | No |
| 1397 | 1949 | 1949.0 | 77.9 | 77.9 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
| 1398 | 3897 | 1948.5 | 69.3 | 34.6 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 1399 | 3896 | 1948.0 | 102.8 | 51.4 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
| 1400 | 1946 | 1946.0 | 42.6 | 42.6 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1401 | 3892 | 1946.0 | 88.2 | 44.1 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1402 | 1946 | 1946.0 | 45.7 | 45.7 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
| 1403 | 3891 | 1945.5 | 80.2 | 40.1 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1404 | 1945 | 1945.0 | 45.6 | 45.6 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1405 | 1945 | 1945.0 | 40.9 | 40.9 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1406 | 3889 | 1944.5 | 87.3 | 43.6 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
| 1407 | 1944 | 1944.0 | 61.9 | 61.9 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1408 | 1943 | 1943.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V BOYDEN | J Exp Med | 1951 | 14803635 | Yes |
| 1409 | 5828 | 1942.7 | 119.4 | 39.8 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1410 | 13594 | 1942.0 | 474.3 | 67.8 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1411 | 1942 | 1942.0 | 33.7 | 33.7 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
| 1412 | 5824 | 1941.3 | 287.5 | 95.8 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 1413 | 1939 | 1939.0 | 53.5 | 53.5 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
| 1414 | 1939 | 1939.0 | 51.5 | 51.5 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
| 1415 | 1938 | 1938.0 | 63.6 | 63.6 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1416 | 5814 | 1938.0 | 118.3 | 39.4 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1417 | 3871 | 1935.5 | 102.6 | 51.3 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1418 | 5806 | 1935.3 | 152.4 | 50.8 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Rohl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1419 | 1934 | 1934.0 | 46.8 | 46.8 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
| 1420 | 15472 | 1934.0 | 493.0 | 61.6 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, | BMJ | 2008 | 18436948 | Yes |
| 1421 | 1932 | 1932.0 | 61.7 | 61.7 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1422 | 1932 | 1932.0 | 41.4 | 41.4 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
| 1423 | 9656 | 1931.2 | 446.3 | 89.3 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 1424 | 1930 | 1930.0 | 50.2 | 50.2 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
| 1425 | 7718 | 1929.5 | 187.3 | 46.8 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1426 | 1929 | 1929.0 | 55.1 | 55.1 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
| 1427 | 7713 | 1928.2 | 202.0 | 50.5 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 1428 | 3856 | 1928.0 | 102.3 | 51.1 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
| 1429 | 1927 | 1927.0 | 68.0 | 68.0 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kummerer | Chemosphere | 2009 | 19185900 | No |
| 1430 | 1927 | 1927.0 | 39.8 | 39.8 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
| 1431 | 3854 | 1927.0 | 123.3 | 61.6 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1432 | 5780 | 1926.7 | 125.2 | 41.7 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1433 | 3850 | 1925.0 | 141.5 | 70.8 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1434 | 1925 | 1925.0 | 55.9 | 55.9 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 1435 | 1924 | 1924.0 | 50.9 | 50.9 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1436 | 3847 | 1923.5 | 123.3 | 61.6 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | No |
| 1437 | 3843 | 1921.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J VOGEL, D M BONNER | J Biol Chem | 1956 | 13278318 | Yes |
| 1438 | 1921 | 1921.0 | 76.3 | 76.3 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1439 | 3842 | 1921.0 | 107.8 | 53.9 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1440 | 1920 | 1920.0 | 39.7 | 39.7 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1441 | 1919 | 1919.0 | 46.7 | 46.7 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
| 1442 | 1918 | 1918.0 | 46.5 | 46.5 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1443 | 3833 | 1916.5 | 127.5 | 63.8 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1444 | 1916 | 1916.0 | 75.8 | 75.8 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | No |
| 1445 | 5742 | 1914.0 | 169.2 | 56.4 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1446 | 3826 | 1913.0 | 190.3 | 95.2 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1447 | 3826 | 1913.0 | 104.8 | 52.4 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 1448 | 5733 | 1911.0 | 116.9 | 39.0 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1449 | 1910 | 1910.0 | 42.1 | 42.1 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1450 | 1909 | 1909.0 | 53.5 | 53.5 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1451 | 1909 | 1909.0 | 51.3 | 51.3 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1452 | 3817 | 1908.5 | 84.7 | 42.4 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1453 | 1908 | 1908.0 | 51.5 | 51.5 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1454 | 5723 | 1907.7 | 337.8 | 112.6 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1455 | 3815 | 1907.5 | 88.5 | 44.2 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
| 1456 | 1906 | 1906.0 | 43.6 | 43.6 | Tricine-SDS-PAGE. | Hermann Schagger | Nat Protoc | 2006 | 17406207 | Yes |
| 1457 | 3812 | 1906.0 | 134.0 | 67.0 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 1458 | 1905 | 1905.0 | 41.0 | 41.0 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
| 1459 | 1905 | 1905.0 | 50.3 | 50.3 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1460 | 1900 | 1900.0 | 87.5 | 87.5 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1461 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H HIRS | J Biol Chem | 1956 | 13319283 | Yes |
| 1462 | 1897 | 1897.0 | 37.5 | 37.5 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1463 | 3793 | 1896.5 | 114.1 | 57.0 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1464 | 1896 | 1896.0 | 76.3 | 76.3 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1465 | 7584 | 1896.0 | 211.5 | 52.9 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1466 | 1895 | 1895.0 | 37.4 | 37.4 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
| 1467 | 1895 | 1895.0 | 49.8 | 49.8 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1468 | 9473 | 1894.6 | 331.9 | 66.4 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1469 | 1894 | 1894.0 | 19.8 | 19.8 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1470 | 7576 | 1894.0 | 251.8 | 63.0 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1471 | 3788 | 1894.0 | 89.1 | 44.5 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1472 | 5680 | 1893.3 | 124.9 | 41.6 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1473 | 1893 | 1893.0 | 37.5 | 37.5 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1474 | 1892 | 1892.0 | 58.8 | 58.8 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
| 1475 | 1892 | 1892.0 | 50.1 | 50.1 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1476 | 3782 | 1891.0 | 99.5 | 49.8 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
| 1477 | 24579 | 1890.7 | 910.8 | 70.1 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. | Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, | Genet Med | 2015 | 25741868 | No |
| 1478 | 3781 | 1890.5 | 112.2 | 56.1 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1479 | 1890 | 1890.0 | 82.6 | 82.6 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
| 1480 | 1889 | 1889.0 | 61.4 | 61.4 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1481 | 3778 | 1889.0 | 76.7 | 38.4 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1482 | 1889 | 1889.0 | 35.1 | 35.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
| 1483 | 1888 | 1888.0 | 64.7 | 64.7 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1484 | 3773 | 1886.5 | 77.4 | 38.7 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1485 | 3772 | 1886.0 | 85.3 | 42.6 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1486 | 1885 | 1885.0 | 33.9 | 33.9 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1487 | 1885 | 1885.0 | 46.4 | 46.4 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
| 1488 | 1885 | 1885.0 | 36.7 | 36.7 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
| 1489 | 1885 | 1885.0 | 44.7 | 44.7 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
| 1490 | 1883 | 1883.0 | 85.9 | 85.9 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
| 1491 | 1883 | 1883.0 | 43.6 | 43.6 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
| 1492 | 1883 | 1883.0 | 36.3 | 36.3 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
| 1493 | 9411 | 1882.2 | 212.8 | 42.6 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1494 | 1880 | 1880.0 | 57.2 | 57.2 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
| 1495 | 3759 | 1879.5 | 86.4 | 43.2 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1496 | 1878 | 1878.0 | 53.8 | 53.8 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
| 1497 | 5632 | 1877.3 | 139.3 | 46.4 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1498 | 1876 | 1876.0 | 42.3 | 42.3 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 1499 | 1876 | 1876.0 | 89.3 | 89.3 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | No |
| 1500 | 1875 | 1875.0 | 33.6 | 33.6 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
| 1501 | 1875 | 1875.0 | 39.1 | 39.1 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
| 1502 | 7499 | 1874.8 | 178.9 | 44.7 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1503 | 1874 | 1874.0 | 47.5 | 47.5 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
| 1504 | 1874 | 1874.0 | 33.7 | 33.7 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
| 1505 | 3747 | 1873.5 | 100.5 | 50.2 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
| 1506 | 3745 | 1872.5 | 189.9 | 95.0 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1507 | 1871 | 1871.0 | 63.9 | 63.9 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 1508 | 3742 | 1871.0 | 77.5 | 38.8 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1509 | 1871 | 1871.0 | 35.9 | 35.9 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
| 1510 | 1870 | 1870.0 | 70.5 | 70.5 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1511 | 3740 | 1870.0 | 75.1 | 37.5 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
| 1512 | 3738 | 1869.0 | 120.3 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1513 | 3738 | 1869.0 | 104.3 | 52.1 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1514 | 1868 | 1868.0 | 48.4 | 48.4 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
| 1515 | 1867 | 1867.0 | 45.9 | 45.9 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1516 | 3730 | 1865.0 | 84.1 | 42.0 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1517 | 1864 | 1864.0 | 42.1 | 42.1 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
| 1518 | 1863 | 1863.0 | 57.7 | 57.7 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1519 | 1863 | 1863.0 | 42.4 | 42.4 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1520 | 1862 | 1862.0 | 43.0 | 43.0 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1521 | 1862 | 1862.0 | 66.3 | 66.3 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1522 | 14892 | 1861.5 | 415.7 | 52.0 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1523 | 3720 | 1860.0 | 85.6 | 42.8 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 1524 | 5578 | 1859.3 | 143.2 | 47.7 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1525 | 1859 | 1859.0 | 44.2 | 44.2 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1526 | 3718 | 1859.0 | 132.6 | 66.3 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1527 | 1859 | 1859.0 | 36.6 | 36.6 | Protein homology detection by HMM-HMM comparison. | Johannes Soding | Bioinformatics | 2005 | 15531603 | Yes |
| 1528 | 1859 | 1859.0 | 42.4 | 42.4 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1529 | 1858 | 1858.0 | 52.1 | 52.1 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1530 | 1858 | 1858.0 | 17.9 | 17.9 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A ROBINSON | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1531 | 3716 | 1858.0 | 77.5 | 38.8 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1532 | 5573 | 1857.7 | 155.6 | 51.9 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallieres, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
| 1533 | 5571 | 1857.0 | 102.8 | 34.3 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1534 | 1856 | 1856.0 | 54.1 | 54.1 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1535 | 1856 | 1856.0 | 37.6 | 37.6 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
| 1536 | 1856 | 1856.0 | 53.1 | 53.1 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1537 | 1856 | 1856.0 | 80.7 | 80.7 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1538 | 3710 | 1855.0 | 142.8 | 71.4 | Assays of glutathione peroxidase. | L Flohe, W A Gunzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1539 | 5558 | 1852.7 | 328.1 | 109.4 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 1540 | 9263 | 1852.6 | 235.9 | 47.2 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1541 | 1851 | 1851.0 | 41.1 | 41.1 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
| 1542 | 3700 | 1850.0 | 95.9 | 48.0 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
| 1543 | 1850 | 1850.0 | 50.2 | 50.2 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1544 | 7398 | 1849.5 | 340.0 | 85.0 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1545 | 1849 | 1849.0 | 54.7 | 54.7 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1546 | 1849 | 1849.0 | 45.5 | 45.5 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 1547 | 1849 | 1849.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1548 | 11089 | 1848.2 | 293.1 | 48.9 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1549 | 1848 | 1848.0 | 41.9 | 41.9 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
| 1550 | 3696 | 1848.0 | 94.7 | 47.4 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 1551 | 3691 | 1845.5 | 113.8 | 56.9 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1552 | 1844 | 1844.0 | 44.2 | 44.2 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1553 | 1844 | 1844.0 | 43.1 | 43.1 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1554 | 1844 | 1844.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D SIMPSON | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1555 | 3688 | 1844.0 | 52.9 | 26.4 | Immunoassay of insulin with insulin-antibody precipitate. | C N HALES, P J RANDLE | Biochem J | 1963 | 13952078 | Yes |
| 1556 | 1843 | 1843.0 | 67.5 | 67.5 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1557 | 1843 | 1843.0 | 43.6 | 43.6 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
| 1558 | 1843 | 1843.0 | 55.1 | 55.1 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1559 | 1842 | 1842.0 | 50.1 | 50.1 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
| 1560 | 1842 | 1842.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C SKOU | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1561 | 3683 | 1841.5 | 106.5 | 53.2 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
| 1562 | 3678 | 1839.0 | 133.3 | 66.7 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1563 | 5515 | 1838.3 | 120.6 | 40.2 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1564 | 1838 | 1838.0 | 60.0 | 60.0 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
| 1565 | 1838 | 1838.0 | 67.4 | 67.4 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
| 1566 | 1837 | 1837.0 | 46.9 | 46.9 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1567 | 3673 | 1836.5 | 92.7 | 46.4 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1568 | 7344 | 1836.0 | 209.1 | 52.3 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1569 | 1836 | 1836.0 | 34.2 | 34.2 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1570 | 3671 | 1835.5 | 117.1 | 58.5 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
| 1571 | 7341 | 1835.2 | 138.9 | 34.7 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1572 | 1835 | 1835.0 | 54.5 | 54.5 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1573 | 1835 | 1835.0 | 62.6 | 62.6 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 1574 | 1834 | 1834.0 | 59.4 | 59.4 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1575 | 5500 | 1833.3 | 140.7 | 46.9 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1576 | 1833 | 1833.0 | 48.6 | 48.6 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1577 | 1833 | 1833.0 | 40.8 | 40.8 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1578 | 5497 | 1832.3 | 118.6 | 39.5 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1579 | 1832 | 1832.0 | 42.7 | 42.7 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
| 1580 | 9159 | 1831.8 | 219.2 | 43.8 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1581 | 1831 | 1831.0 | 41.1 | 41.1 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1582 | 1829 | 1829.0 | 38.3 | 38.3 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1583 | 3656 | 1828.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T CAMPBELL, D W FISKE | Psychol Bull | 1959 | 13634291 | Yes |
| 1584 | 3656 | 1828.0 | 127.7 | 63.9 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | No |
| 1585 | 3656 | 1828.0 | 138.5 | 69.2 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
| 1586 | 3647 | 1823.5 | 90.2 | 45.1 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1587 | 1823 | 1823.0 | 89.0 | 89.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S COHEN | J Biol Chem | 1962 | 13880319 | Yes |
| 1588 | 1823 | 1823.0 | 37.8 | 37.8 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
| 1589 | 1823 | 1823.0 | 95.8 | 95.8 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | No |
| 1590 | 3645 | 1822.5 | 104.3 | 52.1 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
| 1591 | 9112 | 1822.4 | 96.5 | 19.3 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE | JAMA | 1963 | 14044222 | Yes |
| 1592 | 3644 | 1822.0 | 74.7 | 37.4 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
| 1593 | 3643 | 1821.5 | 106.0 | 53.0 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1594 | 1821 | 1821.0 | 36.3 | 36.3 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
| 1595 | 3642 | 1821.0 | 101.6 | 50.8 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
| 1596 | 7275 | 1818.8 | 271.2 | 67.8 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 1597 | 3636 | 1818.0 | 134.7 | 67.3 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1598 | 9083 | 1816.6 | 400.8 | 80.2 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 1599 | 1816 | 1816.0 | 62.8 | 62.8 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
| 1600 | 1814 | 1814.0 | 39.1 | 39.1 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1601 | 1814 | 1814.0 | 37.3 | 37.3 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
| 1602 | 1812 | 1812.0 | 59.1 | 59.1 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1603 | 9056 | 1811.2 | 328.8 | 65.8 | Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. | J B Saunders, O G Aasland, T F Babor, J R de la Fuente, M Grant | Addiction | 1993 | 8329970 | Yes |
| 1604 | 3622 | 1811.0 | 80.3 | 40.1 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
| 1605 | 3621 | 1810.5 | 149.2 | 74.6 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1606 | 18102 | 1810.2 | 564.2 | 56.4 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1607 | 1810 | 1810.0 | 43.0 | 43.0 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1608 | 7238 | 1809.5 | 278.6 | 69.7 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1609 | 1809 | 1809.0 | 19.0 | 19.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1610 | 1808 | 1808.0 | 64.0 | 64.0 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | No |
| 1611 | 5421 | 1807.0 | 174.4 | 58.1 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1612 | 1807 | 1807.0 | 64.4 | 64.4 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1613 | 1806 | 1806.0 | 49.6 | 49.6 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 1614 | 3609 | 1804.5 | 86.1 | 43.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1615 | 1804 | 1804.0 | 43.6 | 43.6 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1616 | 1804 | 1804.0 | 35.8 | 35.8 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
| 1617 | 1800 | 1800.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J WHITNEY | J Physiol | 1953 | 13085295 | Yes |
| 1618 | 1799 | 1799.0 | 97.7 | 97.7 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1619 | 1799 | 1799.0 | 57.3 | 57.3 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
| 1620 | 3598 | 1799.0 | 88.8 | 44.4 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
| 1621 | 3593 | 1796.5 | 165.7 | 82.8 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
| 1622 | 19757 | 1796.1 | 489.8 | 44.5 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1623 | 1796 | 1796.0 | 63.7 | 63.7 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1624 | 1796 | 1796.0 | 55.3 | 55.3 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1625 | 1795 | 1795.0 | 58.6 | 58.6 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1626 | 1795 | 1795.0 | 37.7 | 37.7 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
| 1627 | 3589 | 1794.5 | 74.0 | 37.0 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1628 | 1794 | 1794.0 | 46.9 | 46.9 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1629 | 7175 | 1793.8 | 308.2 | 77.0 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1630 | 3586 | 1793.0 | 162.6 | 81.3 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1631 | 1793 | 1793.0 | 38.4 | 38.4 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
| 1632 | 1793 | 1793.0 | 63.7 | 63.7 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | Yes |
| 1633 | 1792 | 1792.0 | 40.9 | 40.9 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
| 1634 | 1792 | 1792.0 | 45.9 | 45.9 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1635 | 1792 | 1792.0 | 74.2 | 74.2 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
| 1636 | 1791 | 1791.0 | 42.6 | 42.6 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1637 | 1790 | 1790.0 | 54.4 | 54.4 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1638 | 1790 | 1790.0 | 37.6 | 37.6 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1639 | 1790 | 1790.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S HESTRIN | J Biol Chem | 1949 | 18133390 | Yes |
| 1640 | 3579 | 1789.5 | 152.6 | 76.3 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1641 | 1789 | 1789.0 | 53.8 | 53.8 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
| 1642 | 1789 | 1789.0 | 47.1 | 47.1 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
| 1643 | 3575 | 1787.5 | 68.9 | 34.5 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1644 | 1787 | 1787.0 | 59.0 | 59.0 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
| 1645 | 1787 | 1787.0 | 52.9 | 52.9 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1646 | 3574 | 1787.0 | 90.7 | 45.4 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1647 | 1787 | 1787.0 | 64.1 | 64.1 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
| 1648 | 1786 | 1786.0 | 47.1 | 47.1 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
| 1649 | 3572 | 1786.0 | 109.5 | 54.8 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1650 | 1785 | 1785.0 | 0.0 | 0.0 | A new readability yardstick. | R FLESCH | J Appl Psychol | 1948 | 18867058 | Yes |
| 1651 | 3566 | 1783.0 | 86.2 | 43.1 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
| 1652 | 5348 | 1782.7 | 123.6 | 41.2 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Orntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1653 | 7130 | 1782.5 | 246.2 | 61.5 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 1654 | 1782 | 1782.0 | 77.8 | 77.8 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1655 | 1782 | 1782.0 | 75.3 | 75.3 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1656 | 1782 | 1782.0 | 50.7 | 50.7 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1657 | 3564 | 1782.0 | 88.4 | 44.2 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
| 1658 | 3562 | 1781.0 | 86.4 | 43.2 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1659 | 1780 | 1780.0 | 35.8 | 35.8 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1660 | 8896 | 1779.2 | 357.5 | 71.5 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 1661 | 1779 | 1779.0 | 65.9 | 65.9 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1662 | 1779 | 1779.0 | 41.2 | 41.2 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1663 | 1778 | 1778.0 | 49.5 | 49.5 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1664 | 1777 | 1777.0 | 21.3 | 21.3 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1665 | 1776 | 1776.0 | 123.1 | 123.1 | The changing landscape of atherosclerosis. | Peter Libby | Nature | 2021 | 33883728 | No |
| 1666 | 1775 | 1775.0 | 39.1 | 39.1 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1667 | 3547 | 1773.5 | 80.7 | 40.4 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
| 1668 | 1773 | 1773.0 | 46.4 | 46.4 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
| 1669 | 1773 | 1773.0 | 87.7 | 87.7 | Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. | Cynthia Rudin | Nat Mach Intell | 2019 | 35603010 | Yes |
| 1670 | 5318 | 1772.7 | 118.8 | 39.6 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1671 | 1772 | 1772.0 | 64.3 | 64.3 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1672 | 3544 | 1772.0 | 115.3 | 57.6 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | No |
| 1673 | 1771 | 1771.0 | 59.2 | 59.2 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1674 | 3542 | 1771.0 | 72.7 | 36.4 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1675 | 3542 | 1771.0 | 80.4 | 40.2 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
| 1676 | 1771 | 1771.0 | 38.2 | 38.2 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1677 | 5312 | 1770.7 | 114.4 | 38.1 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1678 | 3541 | 1770.5 | 99.7 | 49.9 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
| 1679 | 1770 | 1770.0 | 58.4 | 58.4 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
| 1680 | 1770 | 1770.0 | 33.2 | 33.2 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1681 | 1769 | 1769.0 | 33.6 | 33.6 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
| 1682 | 8845 | 1769.0 | 307.6 | 61.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | J Clin Epidemiol | 2009 | 19631508 | No |
| 1683 | 5303 | 1767.7 | 162.9 | 54.3 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
| 1684 | 3535 | 1767.5 | 43.9 | 21.9 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1685 | 1767 | 1767.0 | 59.6 | 59.6 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1686 | 3532 | 1766.0 | 88.8 | 44.4 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1687 | 3530 | 1765.0 | 150.0 | 75.0 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1688 | 3530 | 1765.0 | 80.0 | 40.0 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 1689 | 1764 | 1764.0 | 47.2 | 47.2 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1690 | 1764 | 1764.0 | 46.0 | 46.0 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 1691 | 1763 | 1763.0 | 38.8 | 38.8 | ATPase activity of myosin correlated with speed of muscle shortening. | M Barany | J Gen Physiol | 1967 | 4227924 | Yes |
| 1692 | 7052 | 1763.0 | 212.7 | 53.2 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1693 | 3525 | 1762.5 | 93.1 | 46.5 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1694 | 10575 | 1762.5 | 212.1 | 35.4 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1695 | 1761 | 1761.0 | 40.2 | 40.2 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
| 1696 | 1761 | 1761.0 | 33.6 | 33.6 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1697 | 1761 | 1761.0 | 40.0 | 40.0 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1698 | 3521 | 1760.5 | 111.4 | 55.7 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 1699 | 21113 | 1759.4 | 627.4 | 52.3 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, | Ann Intern Med | 2009 | 19414839 | Yes |
| 1700 | 3518 | 1759.0 | 225.5 | 112.8 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1701 | 1759 | 1759.0 | 48.7 | 48.7 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
| 1702 | 1759 | 1759.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1703 | 3518 | 1759.0 | 85.1 | 42.5 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1704 | 1758 | 1758.0 | 60.1 | 60.1 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1705 | 1758 | 1758.0 | 17.6 | 17.6 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1706 | 1758 | 1758.0 | 38.3 | 38.3 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Sudhof | Nature | 1995 | 7791897 | No |
| 1707 | 1758 | 1758.0 | 36.3 | 36.3 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
| 1708 | 1757 | 1757.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A TAYLOR | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1709 | 1757 | 1757.0 | 66.4 | 66.4 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 1710 | 1756 | 1756.0 | 44.3 | 44.3 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
| 1711 | 1756 | 1756.0 | 97.7 | 97.7 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 1712 | 1754 | 1754.0 | 53.9 | 53.9 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
| 1713 | 1753 | 1753.0 | 38.4 | 38.4 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1714 | 1753 | 1753.0 | 37.9 | 37.9 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 1715 | 1753 | 1753.0 | 40.2 | 40.2 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
| 1716 | 3505 | 1752.5 | 97.4 | 48.7 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1717 | 1752 | 1752.0 | 59.5 | 59.5 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1718 | 5254 | 1751.3 | 111.7 | 37.2 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1719 | 1751 | 1751.0 | 74.1 | 74.1 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
| 1720 | 1751 | 1751.0 | 38.7 | 38.7 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1721 | 3501 | 1750.5 | 93.4 | 46.7 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1722 | 3501 | 1750.5 | 92.2 | 46.1 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 1723 | 1750 | 1750.0 | 41.8 | 41.8 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1724 | 1750 | 1750.0 | 60.2 | 60.2 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1725 | 3500 | 1750.0 | 128.7 | 64.3 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 1726 | 5248 | 1749.3 | 160.0 | 53.3 | SCANPY: large-scale single-cell gene expression data analysis. | F Alexander Wolf, Philipp Angerer, Fabian J Theis | Genome Biol | 2018 | 29409532 | Yes |
| 1727 | 6997 | 1749.2 | 136.0 | 34.0 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1728 | 15733 | 1748.1 | 476.6 | 53.0 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 1729 | 3495 | 1747.5 | 71.3 | 35.6 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1730 | 1747 | 1747.0 | 40.9 | 40.9 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1731 | 3494 | 1747.0 | 129.0 | 64.5 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1732 | 1747 | 1747.0 | 38.7 | 38.7 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
| 1733 | 1747 | 1747.0 | 41.4 | 41.4 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 1734 | 1746 | 1746.0 | 31.8 | 31.8 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1735 | 1746 | 1746.0 | 58.4 | 58.4 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 1736 | 3491 | 1745.5 | 68.9 | 34.5 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1737 | 3491 | 1745.5 | 96.8 | 48.4 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1738 | 1745 | 1745.0 | 151.0 | 151.0 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
| 1739 | 1744 | 1744.0 | 39.2 | 39.2 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
| 1740 | 3488 | 1744.0 | 221.5 | 110.8 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1741 | 3485 | 1742.5 | 86.1 | 43.0 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1742 | 3485 | 1742.5 | 199.6 | 99.8 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | No |
| 1743 | 6969 | 1742.2 | 216.8 | 54.2 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Soren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1744 | 1742 | 1742.0 | 62.7 | 62.7 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1745 | 1741 | 1741.0 | 68.6 | 68.6 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1746 | 10443 | 1740.5 | 286.8 | 47.8 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1747 | 17403 | 1740.3 | 549.2 | 54.9 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1748 | 1740 | 1740.0 | 73.3 | 73.3 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | No |
| 1749 | 3479 | 1739.5 | 75.3 | 37.6 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
| 1750 | 5217 | 1739.0 | 120.8 | 40.3 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
| 1751 | 1738 | 1738.0 | 45.5 | 45.5 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1752 | 3475 | 1737.5 | 71.7 | 35.9 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flugge | Anal Biochem | 1984 | 6731838 | Yes |
| 1753 | 3475 | 1737.5 | 82.1 | 41.0 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1754 | 5212 | 1737.3 | 273.9 | 91.3 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1755 | 1737 | 1737.0 | 69.4 | 69.4 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | No |
| 1756 | 1737 | 1737.0 | 77.8 | 77.8 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | No |
| 1757 | 1736 | 1736.0 | 55.9 | 55.9 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1758 | 1736 | 1736.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P MORAN | Biometrika | 1950 | 15420245 | Yes |
| 1759 | 1735 | 1735.0 | 69.2 | 69.2 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1760 | 1735 | 1735.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H SELYE | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1761 | 3469 | 1734.5 | 89.8 | 44.9 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
| 1762 | 1734 | 1734.0 | 62.1 | 62.1 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
| 1763 | 1734 | 1734.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J RANKIN | Scott Med J | 1957 | 13432835 | Yes |
| 1764 | 1733 | 1733.0 | 52.3 | 52.3 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1765 | 5196 | 1732.0 | 202.7 | 67.6 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1766 | 1732 | 1732.0 | 31.4 | 31.4 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
| 1767 | 5191 | 1730.3 | 111.4 | 37.1 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1768 | 3460 | 1730.0 | 83.3 | 41.6 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 1769 | 3459 | 1729.5 | 132.1 | 66.0 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1770 | 1729 | 1729.0 | 73.0 | 73.0 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1771 | 1728 | 1728.0 | 56.0 | 56.0 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1772 | 1728 | 1728.0 | 47.3 | 47.3 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 1773 | 1728 | 1728.0 | 69.9 | 69.9 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 1774 | 1728 | 1728.0 | 90.3 | 90.3 | Epidemiology of Prostate Cancer. | Prashanth Rawla | World J Oncol | 2019 | 31068988 | No |
| 1775 | 1727 | 1727.0 | 35.8 | 35.8 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
| 1776 | 1727 | 1727.0 | 30.7 | 30.7 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
| 1777 | 3454 | 1727.0 | 85.5 | 42.8 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
| 1778 | 3453 | 1726.5 | 70.1 | 35.0 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
| 1779 | 1726 | 1726.0 | 74.2 | 74.2 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 1780 | 1726 | 1726.0 | 33.4 | 33.4 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1781 | 1724 | 1724.0 | 31.3 | 31.3 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1782 | 3448 | 1724.0 | 135.1 | 67.5 | Interpreting findings from Mendelian randomization using the MR-Egger method. | Stephen Burgess, Simon G Thompson | Eur J Epidemiol | 2017 | 28527048 | Yes |
| 1783 | 1723 | 1723.0 | 44.3 | 44.3 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
| 1784 | 3446 | 1723.0 | 94.1 | 47.0 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1785 | 1722 | 1722.0 | 65.9 | 65.9 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
| 1786 | 5166 | 1722.0 | 230.3 | 76.8 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1787 | 5165 | 1721.7 | 362.1 | 120.7 | Ferroptosis: mechanisms, biology and role in disease. | Xuejun Jiang, Brent R Stockwell, Marcus Conrad | Nat Rev Mol Cell Biol | 2021 | 33495651 | No |
| 1788 | 6881 | 1720.2 | 214.9 | 53.7 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 1789 | 1719 | 1719.0 | 48.1 | 48.1 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
| 1790 | 3438 | 1719.0 | 65.8 | 32.9 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1791 | 8591 | 1718.2 | 303.2 | 60.6 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | No |
| 1792 | 1718 | 1718.0 | 50.2 | 50.2 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
| 1793 | 6868 | 1717.0 | 140.6 | 35.1 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1794 | 1717 | 1717.0 | 44.2 | 44.2 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
| 1795 | 3434 | 1717.0 | 71.4 | 35.7 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 1796 | 1716 | 1716.0 | 41.9 | 41.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1797 | 3431 | 1715.5 | 73.0 | 36.5 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
| 1798 | 1715 | 1715.0 | 55.7 | 55.7 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 1799 | 1715 | 1715.0 | 51.5 | 51.5 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1800 | 1715 | 1715.0 | 54.5 | 54.5 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1801 | 1714 | 1714.0 | 51.8 | 51.8 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1802 | 3426 | 1713.0 | 77.9 | 39.0 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1803 | 3420 | 1710.0 | 80.6 | 40.3 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1804 | 3419 | 1709.5 | 49.7 | 24.9 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J KARNOVSKY, L ROOTS | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1805 | 3418 | 1709.0 | 196.9 | 98.5 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1806 | 1708 | 1708.0 | 38.0 | 38.0 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
| 1807 | 5123 | 1707.7 | 130.6 | 43.5 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1808 | 1707 | 1707.0 | 45.5 | 45.5 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
| 1809 | 1707 | 1707.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A LASSEN | Physiol Rev | 1959 | 13645234 | Yes |
| 1810 | 1707 | 1707.0 | 62.7 | 62.7 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1811 | 3413 | 1706.5 | 113.1 | 56.5 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 1812 | 3413 | 1706.5 | 103.5 | 51.8 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
| 1813 | 1705 | 1705.0 | 45.4 | 45.4 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jiri Homola | Chem Rev | 2008 | 18229953 | No |
| 1814 | 3408 | 1704.0 | 66.4 | 33.2 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
| 1815 | 3407 | 1703.5 | 80.2 | 40.1 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1816 | 1703 | 1703.0 | 42.8 | 42.8 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
| 1817 | 1703 | 1703.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1818 | 1702 | 1702.0 | 83.6 | 83.6 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerstrom | Addict Behav | 1978 | 735910 | Yes |
| 1819 | 1702 | 1702.0 | 35.3 | 35.3 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1820 | 1702 | 1702.0 | 35.4 | 35.4 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
| 1821 | 3403 | 1701.5 | 83.6 | 41.8 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 1822 | 1701 | 1701.0 | 32.9 | 32.9 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1823 | 1701 | 1701.0 | 47.2 | 47.2 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
| 1824 | 1701 | 1701.0 | 63.9 | 63.9 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | No |
| 1825 | 5102 | 1700.7 | 97.0 | 32.3 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1826 | 1700 | 1700.0 | 55.3 | 55.3 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1827 | 1700 | 1700.0 | 37.6 | 37.6 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
| 1828 | 3399 | 1699.5 | 69.9 | 35.0 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1829 | 3395 | 1697.5 | 75.0 | 37.5 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1830 | 1697 | 1697.0 | 31.1 | 31.1 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1831 | 1697 | 1697.0 | 37.4 | 37.4 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
| 1832 | 1697 | 1697.0 | 43.7 | 43.7 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 1833 | 3393 | 1696.5 | 71.4 | 35.7 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
| 1834 | 1695 | 1695.0 | 40.1 | 40.1 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1835 | 3389 | 1694.5 | 78.8 | 39.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
| 1836 | 3389 | 1694.5 | 110.6 | 55.3 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
| 1837 | 3389 | 1694.5 | 93.0 | 46.5 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
| 1838 | 1694 | 1694.0 | 40.1 | 40.1 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 1839 | 1694 | 1694.0 | 41.2 | 41.2 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1840 | 3388 | 1694.0 | 94.1 | 47.0 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | No |
| 1841 | 8470 | 1694.0 | 288.0 | 57.6 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 1842 | 1693 | 1693.0 | 38.2 | 38.2 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1843 | 1693 | 1693.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G GRAY | J Anat | 1959 | 13829103 | Yes |
| 1844 | 3386 | 1693.0 | 70.6 | 35.3 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
| 1845 | 10156 | 1692.7 | 231.4 | 38.6 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1846 | 1692 | 1692.0 | 38.5 | 38.5 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
| 1847 | 1691 | 1691.0 | 44.8 | 44.8 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
| 1848 | 1690 | 1690.0 | 83.1 | 83.1 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1849 | 1690 | 1690.0 | 22.6 | 22.6 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1850 | 1690 | 1690.0 | 29.3 | 29.3 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H MOLLENHAUER | Stain Technol | 1964 | 14127791 | Yes |
| 1851 | 3379 | 1689.5 | 91.5 | 45.8 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
| 1852 | 1689 | 1689.0 | 31.8 | 31.8 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
| 1853 | 1688 | 1688.0 | 52.9 | 52.9 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
| 1854 | 1688 | 1688.0 | 43.0 | 43.0 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1855 | 1688 | 1688.0 | 45.0 | 45.0 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1856 | 1687 | 1687.0 | 58.7 | 58.7 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
| 1857 | 1687 | 1687.0 | 33.6 | 33.6 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
| 1858 | 5060 | 1686.7 | 109.3 | 36.4 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M G Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1859 | 1685 | 1685.0 | 48.9 | 48.9 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1860 | 10105 | 1684.2 | 347.8 | 58.0 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1861 | 1684 | 1684.0 | 43.2 | 43.2 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1862 | 3368 | 1684.0 | 98.6 | 49.3 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1863 | 1684 | 1684.0 | 29.8 | 29.8 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
| 1864 | 3366 | 1683.0 | 120.0 | 60.0 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | No |
| 1865 | 1682 | 1682.0 | 73.4 | 73.4 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1866 | 1682 | 1682.0 | 41.6 | 41.6 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
| 1867 | 1681 | 1681.0 | 38.1 | 38.1 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
| 1868 | 1681 | 1681.0 | 14.0 | 14.0 | Chromatographic Separation Of Human Brain Gangliosides. | L SVENNERHOLM | J Neurochem | 1963 | 14066623 | Yes |
| 1869 | 1680 | 1680.0 | 43.1 | 43.1 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
| 1870 | 3360 | 1680.0 | 64.2 | 32.1 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
| 1871 | 1679 | 1679.0 | 48.5 | 48.5 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 1872 | 1678 | 1678.0 | 68.6 | 68.6 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 1873 | 3355 | 1677.5 | 116.4 | 58.2 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | No |
| 1874 | 1677 | 1677.0 | 58.2 | 58.2 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
| 1875 | 3353 | 1676.5 | 72.4 | 36.2 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
| 1876 | 1676 | 1676.0 | 32.0 | 32.0 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1877 | 1676 | 1676.0 | 32.3 | 32.3 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1878 | 10056 | 1676.0 | 226.9 | 37.8 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O Lotvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 1879 | 3352 | 1676.0 | 126.6 | 63.3 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | No |
| 1880 | 1676 | 1676.0 | 49.8 | 49.8 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
| 1881 | 1675 | 1675.0 | 68.6 | 68.6 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | No |
| 1882 | 1674 | 1674.0 | 49.3 | 49.3 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
| 1883 | 1674 | 1674.0 | 40.3 | 40.3 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
| 1884 | 1674 | 1674.0 | 36.6 | 36.6 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
| 1885 | 3346 | 1673.0 | 94.4 | 47.2 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
| 1886 | 1673 | 1673.0 | 39.4 | 39.4 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
| 1887 | 11710 | 1672.9 | 368.5 | 52.6 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | J Clin Epidemiol | 2008 | 18313558 | Yes |
| 1888 | 1672 | 1672.0 | 53.2 | 53.2 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 1889 | 1671 | 1671.0 | 44.9 | 44.9 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 1890 | 1671 | 1671.0 | 197.1 | 197.1 | Epidemiology of chronic kidney disease: an update 2022. | Csaba P Kovesdy | Kidney Int Suppl (2011) | 2022 | 35529086 | No |
| 1891 | 1670 | 1670.0 | 33.7 | 33.7 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
| 1892 | 1670 | 1670.0 | 62.7 | 62.7 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | No |
| 1893 | 1669 | 1669.0 | 58.7 | 58.7 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1894 | 1669 | 1669.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F BOAS | J Biol Chem | 1953 | 13117829 | Yes |
| 1895 | 5006 | 1668.7 | 137.5 | 45.8 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1896 | 1668 | 1668.0 | 41.7 | 41.7 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1897 | 1668 | 1668.0 | 34.9 | 34.9 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
| 1898 | 1667 | 1667.0 | 52.0 | 52.0 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1899 | 1667 | 1667.0 | 60.1 | 60.1 | Inflammation, metaflammation and immunometabolic disorders. | Gokhan S Hotamisligil | Nature | 2017 | 28179656 | No |
| 1900 | 3332 | 1666.0 | 54.3 | 27.1 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T OMURA, R SATO | J Biol Chem | 1964 | 14209972 | Yes |
| 1901 | 9992 | 1665.3 | 319.5 | 53.2 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 1902 | 1665 | 1665.0 | 37.5 | 37.5 | Upconversion and anti-Stokes processes with f and d ions in solids. | Francois Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1903 | 1664 | 1664.0 | 63.4 | 63.4 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1904 | 1664 | 1664.0 | 37.3 | 37.3 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
| 1905 | 6656 | 1664.0 | 155.5 | 38.9 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1906 | 3326 | 1663.0 | 60.3 | 30.1 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1907 | 3325 | 1662.5 | 85.6 | 42.8 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1908 | 3325 | 1662.5 | 69.5 | 34.8 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
| 1909 | 1662 | 1662.0 | 39.1 | 39.1 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 1910 | 4984 | 1661.3 | 134.3 | 44.8 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 1911 | 1661 | 1661.0 | 49.0 | 49.0 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1912 | 1661 | 1661.0 | 47.0 | 47.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1913 | 1661 | 1661.0 | 65.2 | 65.2 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 1914 | 1660 | 1660.0 | 31.3 | 31.3 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1915 | 3319 | 1659.5 | 105.2 | 52.6 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 1916 | 3319 | 1659.5 | 80.8 | 40.4 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 1917 | 1659 | 1659.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S KETY | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1918 | 6635 | 1658.8 | 151.8 | 38.0 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1919 | 8292 | 1658.4 | 351.0 | 70.2 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 1920 | 1658 | 1658.0 | 56.8 | 56.8 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
| 1921 | 3316 | 1658.0 | 71.3 | 35.6 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1922 | 4974 | 1658.0 | 124.8 | 41.6 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1923 | 3316 | 1658.0 | 97.3 | 48.6 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
| 1924 | 3315 | 1657.5 | 83.0 | 41.5 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1925 | 1657 | 1657.0 | 36.2 | 36.2 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | Yes |
| 1926 | 4971 | 1657.0 | 104.2 | 34.7 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 1927 | 3313 | 1656.5 | 93.8 | 46.9 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 1928 | 4969 | 1656.3 | 118.6 | 39.5 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1929 | 1656 | 1656.0 | 47.4 | 47.4 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
| 1930 | 1654 | 1654.0 | 39.1 | 39.1 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1931 | 1653 | 1653.0 | 53.2 | 53.2 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1932 | 1653 | 1653.0 | 31.4 | 31.4 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
| 1933 | 1652 | 1652.0 | 36.7 | 36.7 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1934 | 4956 | 1652.0 | 163.3 | 54.4 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 1935 | 3303 | 1651.5 | 92.3 | 46.1 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1936 | 1651 | 1651.0 | 50.1 | 50.1 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
| 1937 | 1651 | 1651.0 | 22.5 | 22.5 | Structural considerations in the interaction of DNA and acridines. | L S LERMAN | J Mol Biol | 1961 | 13761054 | Yes |
| 1938 | 3301 | 1650.5 | 67.3 | 33.6 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massague | Cell | 2006 | 17110329 | No |
| 1939 | 6599 | 1649.8 | 278.0 | 69.5 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 1940 | 1649 | 1649.0 | 41.4 | 41.4 | Aspergillus fumigatus and aspergillosis. | J P Latge | Clin Microbiol Rev | 1999 | 10194462 | No |
| 1941 | 1649 | 1649.0 | 76.1 | 76.1 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1942 | 3298 | 1649.0 | 74.3 | 37.1 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
| 1943 | 1648 | 1648.0 | 50.1 | 50.1 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 1944 | 1648 | 1648.0 | 39.4 | 39.4 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 1945 | 1648 | 1648.0 | 51.3 | 51.3 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | No |
| 1946 | 1647 | 1647.0 | 48.3 | 48.3 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
| 1947 | 3293 | 1646.5 | 66.0 | 33.0 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
| 1948 | 3293 | 1646.5 | 65.7 | 32.9 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1949 | 1646 | 1646.0 | 33.2 | 33.2 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
| 1950 | 1646 | 1646.0 | 45.0 | 45.0 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 1951 | 1646 | 1646.0 | 30.2 | 30.2 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
| 1952 | 3291 | 1645.5 | 59.0 | 29.5 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
| 1953 | 1645 | 1645.0 | 34.8 | 34.8 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
| 1954 | 3289 | 1644.5 | 96.7 | 48.4 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 1955 | 3289 | 1644.5 | 71.3 | 35.6 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
| 1956 | 3288 | 1644.0 | 92.9 | 46.5 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 1957 | 1643 | 1643.0 | 46.9 | 46.9 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
| 1958 | 1643 | 1643.0 | 56.6 | 56.6 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
| 1959 | 3286 | 1643.0 | 77.5 | 38.8 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 1960 | 1643 | 1643.0 | 27.5 | 27.5 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
| 1961 | 1643 | 1643.0 | 43.8 | 43.8 | Bioactive microbial metabolites. | Janos Berdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
| 1962 | 1642 | 1642.0 | 71.9 | 71.9 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
| 1963 | 4926 | 1642.0 | 124.7 | 41.6 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
| 1964 | 1642 | 1642.0 | 28.6 | 28.6 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 1965 | 1642 | 1642.0 | 84.5 | 84.5 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | No |
| 1966 | 1641 | 1641.0 | 44.9 | 44.9 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 1967 | 1641 | 1641.0 | 29.8 | 29.8 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
| 1968 | 1641 | 1641.0 | 39.1 | 39.1 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvarinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 1969 | 3281 | 1640.5 | 348.0 | 174.0 | Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. | Luke A McGuinness, Julian P T Higgins | Res Synth Methods | 2021 | 32336025 | Yes |
| 1970 | 4921 | 1640.3 | 177.4 | 59.1 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 1971 | 1640 | 1640.0 | 34.3 | 34.3 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 1972 | 1640 | 1640.0 | 30.3 | 30.3 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 1973 | 13111 | 1638.9 | 308.1 | 38.5 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, | N Engl J Med | 2002 | 11832527 | Yes |
| 1974 | 1638 | 1638.0 | 70.9 | 70.9 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1975 | 1638 | 1638.0 | 31.5 | 31.5 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1976 | 3274 | 1637.0 | 74.7 | 37.4 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1977 | 1637 | 1637.0 | 51.0 | 51.0 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
| 1978 | 1637 | 1637.0 | 43.0 | 43.0 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
| 1979 | 1636 | 1636.0 | 51.3 | 51.3 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
| 1980 | 1636 | 1636.0 | 37.0 | 37.0 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
| 1981 | 3271 | 1635.5 | 122.5 | 61.2 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | No |
| 1982 | 1635 | 1635.0 | 101.8 | 101.8 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D MATTINGLY | J Clin Pathol | 1962 | 14471419 | Yes |
| 1983 | 1635 | 1635.0 | 37.7 | 37.7 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
| 1984 | 1634 | 1634.0 | 30.2 | 30.2 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
| 1985 | 1633 | 1633.0 | 28.6 | 28.6 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 1986 | 3266 | 1633.0 | 92.3 | 46.1 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 1987 | 1633 | 1633.0 | 30.1 | 30.1 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 1988 | 1633 | 1633.0 | 60.1 | 60.1 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | No |
| 1989 | 3264 | 1632.0 | 76.6 | 38.3 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1990 | 1632 | 1632.0 | 42.5 | 42.5 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1991 | 3263 | 1631.5 | 182.6 | 91.3 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J MARMUR, P DOTY | J Mol Biol | 1962 | 14470099 | Yes |
| 1992 | 3261 | 1630.5 | 96.3 | 48.1 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow, | Pediatrics | 2007 | 18055651 | Yes |
| 1993 | 1630 | 1630.0 | 34.6 | 34.6 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
| 1994 | 4890 | 1630.0 | 93.3 | 31.1 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jurg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 1995 | 3260 | 1630.0 | 94.0 | 47.0 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 1996 | 3257 | 1628.5 | 65.6 | 32.8 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 1997 | 8142 | 1628.4 | 292.6 | 58.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Int J Surg | 2010 | 20171303 | No |
| 1998 | 1628 | 1628.0 | 58.2 | 58.2 | Cell damage in the brain: a speculative synthesis. | B K Siesjo | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
| 1999 | 1628 | 1628.0 | 35.7 | 35.7 | Thiazolidinediones. | Hannele Yki-Jarvinen | N Engl J Med | 2004 | 15356308 | No |
| 2000 | 6511 | 1627.8 | 208.5 | 52.1 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 2001 | 1627 | 1627.0 | 45.6 | 45.6 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 2002 | 1627 | 1627.0 | 111.8 | 111.8 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 2003 | 1627 | 1627.0 | 29.9 | 29.9 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
| 2004 | 4881 | 1627.0 | 53.9 | 18.0 | Improved method for the determination of blood glutathione. | E BEUTLER, O DURON, B M KELLY | J Lab Clin Med | 1963 | 13967893 | Yes |
| 2005 | 3254 | 1627.0 | 67.1 | 33.5 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
| 2006 | 1626 | 1626.0 | 71.6 | 71.6 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 2007 | 3252 | 1626.0 | 78.2 | 39.1 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 2008 | 3252 | 1626.0 | 63.7 | 31.9 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 2009 | 3252 | 1626.0 | 103.6 | 51.8 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | No |
| 2010 | 4876 | 1625.3 | 135.7 | 45.2 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 2011 | 1625 | 1625.0 | 29.3 | 29.3 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 2012 | 3248 | 1624.0 | 194.2 | 97.1 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 2013 | 3248 | 1624.0 | 81.3 | 40.6 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 2014 | 1623 | 1623.0 | 46.1 | 46.1 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinas | Science | 1988 | 3059497 | No |
| 2015 | 1623 | 1623.0 | 51.0 | 51.0 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2016 | 1623 | 1623.0 | 51.0 | 51.0 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2017 | 3245 | 1622.5 | 77.8 | 38.9 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 2018 | 1622 | 1622.0 | 52.6 | 52.6 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 2019 | 1622 | 1622.0 | 40.4 | 40.4 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 2020 | 1622 | 1622.0 | 47.3 | 47.3 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
| 2021 | 3243 | 1621.5 | 62.3 | 31.1 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 2022 | 6483 | 1620.8 | 211.0 | 52.8 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 2023 | 3239 | 1619.5 | 60.3 | 30.1 | Mutations affecting segment number and polarity in Drosophila. | C Nusslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 2024 | 9715 | 1619.2 | 275.6 | 45.9 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 2025 | 3238 | 1619.0 | 78.9 | 39.5 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
| 2026 | 1619 | 1619.0 | 26.1 | 26.1 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
| 2027 | 1619 | 1619.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W KUFFLER | J Neurophysiol | 1953 | 13035466 | Yes |
| 2028 | 6473 | 1618.2 | 249.0 | 62.2 | Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. | Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess | Genet Epidemiol | 2016 | 27061298 | Yes |
| 2029 | 1618 | 1618.0 | 56.3 | 56.3 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2030 | 3236 | 1618.0 | 82.6 | 41.3 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
| 2031 | 1617 | 1617.0 | 51.3 | 51.3 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
| 2032 | 1617 | 1617.0 | 63.3 | 63.3 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2033 | 1616 | 1616.0 | 34.3 | 34.3 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 2034 | 1616 | 1616.0 | 33.5 | 33.5 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
| 2035 | 1616 | 1616.0 | 32.7 | 32.7 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 2036 | 3231 | 1615.5 | 77.2 | 38.6 | Dali server: conservation mapping in 3D. | Liisa Holm, Paivi Rosenstrom | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 2037 | 11307 | 1615.3 | 265.5 | 37.9 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 2038 | 1615 | 1615.0 | 29.3 | 29.3 | How cells read TGF-beta signals. | J Massague | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
| 2039 | 4845 | 1615.0 | 115.2 | 38.4 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 2040 | 1615 | 1615.0 | 32.9 | 32.9 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 2041 | 1613 | 1613.0 | 28.9 | 28.9 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 2042 | 4837 | 1612.3 | 117.6 | 39.2 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman, | Hepatology | 2005 | 16250051 | No |
| 2043 | 1612 | 1612.0 | 31.4 | 31.4 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 2044 | 1611 | 1611.0 | 42.9 | 42.9 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | No |
| 2045 | 1610 | 1610.0 | 19.5 | 19.5 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W CLELAND | Biochemistry | 1964 | 14192894 | Yes |
| 2046 | 3219 | 1609.5 | 78.1 | 39.0 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Despres, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 2047 | 3218 | 1609.0 | 111.1 | 55.5 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 2048 | 3218 | 1609.0 | 79.4 | 39.7 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2049 | 3218 | 1609.0 | 57.2 | 28.6 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 2050 | 4826 | 1608.7 | 88.4 | 29.5 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 2051 | 3217 | 1608.5 | 88.1 | 44.0 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
| 2052 | 3215 | 1607.5 | 104.7 | 52.4 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2053 | 1607 | 1607.0 | 36.4 | 36.4 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
| 2054 | 1607 | 1607.0 | 49.2 | 49.2 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 2055 | 1607 | 1607.0 | 34.1 | 34.1 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
| 2056 | 3213 | 1606.5 | 91.4 | 45.7 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 2057 | 16061 | 1606.1 | 374.8 | 37.5 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 2058 | 1606 | 1606.0 | 41.8 | 41.8 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
| 2059 | 1606 | 1606.0 | 34.1 | 34.1 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 2060 | 3212 | 1606.0 | 76.7 | 38.4 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2061 | 1606 | 1606.0 | 54.2 | 54.2 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | No |
| 2062 | 3211 | 1605.5 | 113.1 | 56.5 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 2063 | 1605 | 1605.0 | 29.3 | 29.3 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
| 2064 | 3210 | 1605.0 | 67.1 | 33.5 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
| 2065 | 3210 | 1605.0 | 60.9 | 30.4 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 2066 | 3210 | 1605.0 | 63.1 | 31.6 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
| 2067 | 1605 | 1605.0 | 46.4 | 46.4 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
| 2068 | 1604 | 1604.0 | 49.7 | 49.7 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
| 2069 | 3207 | 1603.5 | 186.8 | 93.4 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. | Helmut Sies, Dean P Jones | Nat Rev Mol Cell Biol | 2020 | 32231263 | No |
| 2070 | 1603 | 1603.0 | 33.1 | 33.1 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
| 2071 | 4806 | 1602.0 | 93.9 | 31.3 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 2072 | 1602 | 1602.0 | 39.5 | 39.5 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 2073 | 1601 | 1601.0 | 39.7 | 39.7 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2074 | 1601 | 1601.0 | 35.3 | 35.3 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
| 2075 | 1601 | 1601.0 | 44.5 | 44.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 2076 | 1601 | 1601.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 2077 | 1601 | 1601.0 | 47.6 | 47.6 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 2078 | 1600 | 1600.0 | 36.5 | 36.5 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
| 2079 | 1600 | 1600.0 | 51.8 | 51.8 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Frohlich | Int J Nanomedicine | 2012 | 23144561 | No |
| 2080 | 4799 | 1599.7 | 115.2 | 38.4 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2081 | 7998 | 1599.6 | 153.2 | 30.6 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 2082 | 3198 | 1599.0 | 77.4 | 38.7 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 2083 | 3198 | 1599.0 | 63.4 | 31.7 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
| 2084 | 1598 | 1598.0 | 31.3 | 31.3 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
| 2085 | 3196 | 1598.0 | 101.3 | 50.6 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | No |
| 2086 | 1598 | 1598.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L WELCH | Biometrika | 1947 | 20287819 | Yes |
| 2087 | 4789 | 1596.3 | 263.9 | 88.0 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 2088 | 1596 | 1596.0 | 81.3 | 81.3 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2089 | 1596 | 1596.0 | 45.5 | 45.5 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
| 2090 | 1596 | 1596.0 | 44.6 | 44.6 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | No |
| 2091 | 4783 | 1594.3 | 151.4 | 50.5 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graca Raposo, Clotilde Thery | Annu Rev Cell Dev Biol | 2014 | 25288114 | No |
| 2092 | 12754 | 1594.2 | 310.0 | 38.8 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2093 | 1594 | 1594.0 | 33.2 | 33.2 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 2094 | 4780 | 1593.3 | 120.3 | 40.1 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2095 | 1593 | 1593.0 | 48.2 | 48.2 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 2096 | 3186 | 1593.0 | 72.2 | 36.1 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
| 2097 | 3185 | 1592.5 | 60.2 | 30.1 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 2098 | 1592 | 1592.0 | 40.7 | 40.7 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 2099 | 1592 | 1592.0 | 66.3 | 66.3 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 2100 | 1590 | 1590.0 | 37.6 | 37.6 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 2101 | 1590 | 1590.0 | 42.7 | 42.7 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
| 2102 | 6355 | 1588.8 | 155.0 | 38.8 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2103 | 7942 | 1588.4 | 271.4 | 54.3 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 2104 | 3176 | 1588.0 | 96.1 | 48.0 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 2105 | 1588 | 1588.0 | 50.0 | 50.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2106 | 3176 | 1588.0 | 61.5 | 30.8 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
| 2107 | 6349 | 1587.2 | 149.7 | 37.4 | Universal sample preparation method for proteome analysis. | Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2108 | 1587 | 1587.0 | 46.9 | 46.9 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2109 | 6348 | 1587.0 | 260.0 | 65.0 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
| 2110 | 1586 | 1586.0 | 41.2 | 41.2 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 2111 | 1586 | 1586.0 | 35.1 | 35.1 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
| 2112 | 1586 | 1586.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H EAGLE | Science | 1955 | 13255879 | Yes |
| 2113 | 3170 | 1585.0 | 100.7 | 50.4 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
| 2114 | 20605 | 1585.0 | 515.2 | 39.6 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2115 | 4754 | 1584.7 | 156.9 | 52.3 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
| 2116 | 1584 | 1584.0 | 39.4 | 39.4 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 2117 | 1583 | 1583.0 | 31.4 | 31.4 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 2118 | 1582 | 1582.0 | 58.0 | 58.0 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylha | Soc Sci Med | 2009 | 19520474 | Yes |
| 2119 | 3163 | 1581.5 | 174.6 | 87.3 | Osteoarthritis. | David J Hunter, Sita Bierma-Zeinstra | Lancet | 2019 | 31034380 | No |
| 2120 | 4744 | 1581.3 | 92.0 | 30.7 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2121 | 1580 | 1580.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C HUMMEL | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 2122 | 6319 | 1579.8 | 146.7 | 36.7 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | No |
| 2123 | 3158 | 1579.0 | 66.0 | 33.0 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2124 | 1579 | 1579.0 | 79.2 | 79.2 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 2125 | 1579 | 1579.0 | 52.5 | 52.5 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
| 2126 | 1577 | 1577.0 | 64.8 | 64.8 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
| 2127 | 1577 | 1577.0 | 52.7 | 52.7 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2128 | 1577 | 1577.0 | 44.9 | 44.9 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
| 2129 | 1577 | 1577.0 | 44.6 | 44.6 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2130 | 3153 | 1576.5 | 98.0 | 49.0 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 2131 | 3152 | 1576.0 | 95.9 | 48.0 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
| 2132 | 1576 | 1576.0 | 55.3 | 55.3 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 2133 | 3151 | 1575.5 | 148.9 | 74.5 | Breast Cancer Treatment: A Review. | Adrienne G Waks, Eric P Winer | JAMA | 2019 | 30667505 | No |
| 2134 | 3149 | 1574.5 | 88.9 | 44.5 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | No |
| 2135 | 6298 | 1574.5 | 277.2 | 69.3 | Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do | Nat Genet | 2018 | 29686387 | Yes |
| 2136 | 1574 | 1574.0 | 37.1 | 37.1 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
| 2137 | 6293 | 1573.2 | 119.0 | 29.8 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2138 | 1573 | 1573.0 | 42.5 | 42.5 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
| 2139 | 1572 | 1572.0 | 58.9 | 58.9 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 2140 | 1572 | 1572.0 | 38.5 | 38.5 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
| 2141 | 3144 | 1572.0 | 79.9 | 40.0 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 2142 | 1572 | 1572.0 | 58.5 | 58.5 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2143 | 4714 | 1571.3 | 141.2 | 47.1 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2144 | 6283 | 1570.8 | 179.8 | 45.0 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2145 | 1570 | 1570.0 | 76.0 | 76.0 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | No |
| 2146 | 3136 | 1568.0 | 21.7 | 10.8 | Junctional complexes in various epithelia. | M G FARQUHAR, G E PALADE | J Cell Biol | 1963 | 13944428 | Yes |
| 2147 | 3132 | 1566.0 | 68.1 | 34.0 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 2148 | 1566 | 1566.0 | 41.5 | 41.5 | The pollution of the marine environment by plastic debris: a review. | Jose G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
| 2149 | 1565 | 1565.0 | 43.6 | 43.6 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2150 | 1565 | 1565.0 | 32.8 | 32.8 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2151 | 1565 | 1565.0 | 42.6 | 42.6 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
| 2152 | 4694 | 1564.7 | 128.2 | 42.7 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
| 2153 | 1564 | 1564.0 | 40.7 | 40.7 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2154 | 1563 | 1563.0 | 56.9 | 56.9 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2155 | 4688 | 1562.7 | 110.5 | 36.8 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 2156 | 3125 | 1562.5 | 38.6 | 19.3 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 2157 | 3124 | 1562.0 | 97.0 | 48.5 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
| 2158 | 3124 | 1562.0 | 60.5 | 30.2 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
| 2159 | 1562 | 1562.0 | 31.3 | 31.3 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
| 2160 | 1561 | 1561.0 | 36.4 | 36.4 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 2161 | 1560 | 1560.0 | 59.7 | 59.7 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2162 | 3120 | 1560.0 | 99.8 | 49.9 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 2163 | 1560 | 1560.0 | 49.0 | 49.0 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2164 | 1560 | 1560.0 | 28.0 | 28.0 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
| 2165 | 1560 | 1560.0 | 33.1 | 33.1 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2166 | 1560 | 1560.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 2167 | 10915 | 1559.3 | 351.8 | 50.3 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 2168 | 1559 | 1559.0 | 46.4 | 46.4 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | No |
| 2169 | 1558 | 1558.0 | 31.9 | 31.9 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
| 2170 | 1558 | 1558.0 | 46.2 | 46.2 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
| 2171 | 1558 | 1558.0 | 52.6 | 52.6 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | No |
| 2172 | 1557 | 1557.0 | 53.3 | 53.3 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
| 2173 | 4671 | 1557.0 | 160.1 | 53.4 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | No |
| 2174 | 1556 | 1556.0 | 33.8 | 33.8 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2175 | 1555 | 1555.0 | 68.6 | 68.6 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2176 | 4662 | 1554.0 | 102.8 | 34.3 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 2177 | 1554 | 1554.0 | 32.6 | 32.6 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 2178 | 1554 | 1554.0 | 46.4 | 46.4 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2179 | 1553 | 1553.0 | 43.8 | 43.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
| 2180 | 10871 | 1553.0 | 227.1 | 32.4 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2181 | 1552 | 1552.0 | 29.6 | 29.6 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L RAMANATHAN | J Appl Physiol | 1964 | 14173555 | Yes |
| 2182 | 3104 | 1552.0 | 89.2 | 44.6 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 2183 | 1551 | 1551.0 | 39.6 | 39.6 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
| 2184 | 1550 | 1550.0 | 55.0 | 55.0 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
| 2185 | 3099 | 1549.5 | 116.2 | 58.1 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | Yes |
| 2186 | 1549 | 1549.0 | 92.1 | 92.1 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2187 | 1549 | 1549.0 | 18.3 | 18.3 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2188 | 1549 | 1549.0 | 44.9 | 44.9 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 2189 | 4646 | 1548.7 | 126.5 | 42.2 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2190 | 4645 | 1548.3 | 155.8 | 51.9 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2191 | 1548 | 1548.0 | 43.0 | 43.0 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 2192 | 1548 | 1548.0 | 12.5 | 12.5 | The Relation Of Recombination To Mutational Advance. | H J MULLER | Mutat Res | 1964 | 14195748 | Yes |
| 2193 | 1547 | 1547.0 | 50.4 | 50.4 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2194 | 4638 | 1546.0 | 109.9 | 36.6 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2195 | 1546 | 1546.0 | 34.0 | 34.0 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
| 2196 | 3089 | 1544.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbruck | Genetics | 1943 | 17247100 | Yes |
| 2197 | 4633 | 1544.3 | 89.1 | 29.7 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 2198 | 3088 | 1544.0 | 236.1 | 118.0 | Gut microbiota in human metabolic health and disease. | Yong Fan, Oluf Pedersen | Nat Rev Microbiol | 2021 | 32887946 | No |
| 2199 | 3087 | 1543.5 | 70.9 | 35.5 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 2200 | 1543 | 1543.0 | 33.4 | 33.4 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
| 2201 | 9256 | 1542.7 | 271.4 | 45.2 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 2202 | 4626 | 1542.0 | 96.8 | 32.3 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 2203 | 1542 | 1542.0 | 98.3 | 98.3 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2204 | 3083 | 1541.5 | 66.7 | 33.4 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
| 2205 | 1541 | 1541.0 | 37.6 | 37.6 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2206 | 1540 | 1540.0 | 35.5 | 35.5 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2207 | 3080 | 1540.0 | 109.3 | 54.6 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | No |
| 2208 | 1539 | 1539.0 | 29.9 | 29.9 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2209 | 1539 | 1539.0 | 45.8 | 45.8 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
| 2210 | 1539 | 1539.0 | 45.7 | 45.7 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2211 | 3078 | 1539.0 | 88.1 | 44.0 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2212 | 1538 | 1538.0 | 38.3 | 38.3 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | No |
| 2213 | 1537 | 1537.0 | 57.8 | 57.8 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2214 | 1537 | 1537.0 | 33.8 | 33.8 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2215 | 3074 | 1537.0 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G SCHMIDT, S J THANNHAUSER | J Biol Chem | 1945 | 21005717 | Yes |
| 2216 | 4610 | 1536.7 | 93.6 | 31.2 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 2217 | 3073 | 1536.5 | 84.5 | 42.2 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marcais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 2218 | 4609 | 1536.3 | 104.7 | 34.9 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
| 2219 | 1536 | 1536.0 | 43.7 | 43.7 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2220 | 1536 | 1536.0 | 59.4 | 59.4 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2221 | 1535 | 1535.0 | 56.9 | 56.9 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2222 | 1534 | 1534.0 | 44.7 | 44.7 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2223 | 3067 | 1533.5 | 60.0 | 30.0 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 2224 | 1533 | 1533.0 | 33.5 | 33.5 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 2225 | 1533 | 1533.0 | 40.8 | 40.8 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
| 2226 | 1533 | 1533.0 | 50.3 | 50.3 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2227 | 1533 | 1533.0 | 48.8 | 48.8 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
| 2228 | 3063 | 1531.5 | 103.8 | 51.9 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2229 | 1531 | 1531.0 | 21.3 | 21.3 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2230 | 1531 | 1531.0 | 37.6 | 37.6 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2231 | 1531 | 1531.0 | 42.4 | 42.4 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | No |
| 2232 | 3061 | 1530.5 | 58.8 | 29.4 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
| 2233 | 1530 | 1530.0 | 50.2 | 50.2 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2234 | 1530 | 1530.0 | 57.4 | 57.4 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2235 | 1530 | 1530.0 | 35.1 | 35.1 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 2236 | 3059 | 1529.5 | 90.2 | 45.1 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2237 | 4587 | 1529.0 | 101.6 | 33.9 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
| 2238 | 1529 | 1529.0 | 39.7 | 39.7 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2239 | 6115 | 1528.8 | 303.6 | 75.9 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 2240 | 1528 | 1528.0 | 26.5 | 26.5 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
| 2241 | 1528 | 1528.0 | 30.7 | 30.7 | Antigen-Antibody Crossed Electrophoresis. | C B LAURELL | Anal Biochem | 1965 | 14302464 | Yes |
| 2242 | 1528 | 1528.0 | 34.4 | 34.4 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | No |
| 2243 | 4583 | 1527.7 | 166.0 | 55.3 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2244 | 6109 | 1527.2 | 130.4 | 32.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2245 | 4581 | 1527.0 | 141.6 | 47.2 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2246 | 1527 | 1527.0 | 48.0 | 48.0 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 2247 | 1526 | 1526.0 | 44.8 | 44.8 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2248 | 1526 | 1526.0 | 40.9 | 40.9 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
| 2249 | 1525 | 1525.0 | 38.6 | 38.6 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 2250 | 1525 | 1525.0 | 44.9 | 44.9 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2251 | 3050 | 1525.0 | 85.0 | 42.5 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2252 | 1524 | 1524.0 | 42.7 | 42.7 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
| 2253 | 1523 | 1523.0 | 27.0 | 27.0 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2254 | 1523 | 1523.0 | 19.2 | 19.2 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2255 | 1523 | 1523.0 | 32.1 | 32.1 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
| 2256 | 3044 | 1522.0 | 78.0 | 39.0 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
| 2257 | 1521 | 1521.0 | 22.2 | 22.2 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2258 | 1521 | 1521.0 | 25.2 | 25.2 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K FUXE | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2259 | 1520 | 1520.0 | 38.9 | 38.9 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
| 2260 | 3039 | 1519.5 | 98.5 | 49.2 | Nitric oxide synthases: regulation and function. | Ulrich Forstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | No |
| 2261 | 4558 | 1519.3 | 97.4 | 32.5 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2262 | 1519 | 1519.0 | 38.3 | 38.3 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
| 2263 | 1519 | 1519.0 | 36.2 | 36.2 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
| 2264 | 1518 | 1518.0 | 37.8 | 37.8 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 2265 | 3036 | 1518.0 | 68.5 | 34.2 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Janicke | Cell Death Differ | 1999 | 10200555 | No |
| 2266 | 3035 | 1517.5 | 61.9 | 30.9 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 2267 | 4552 | 1517.3 | 261.5 | 87.2 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A WINTER, E A RISLEY, G W NUSS | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2268 | 1517 | 1517.0 | 50.5 | 50.5 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2269 | 1516 | 1516.0 | 39.7 | 39.7 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2270 | 3032 | 1516.0 | 92.9 | 46.5 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
| 2271 | 1516 | 1516.0 | 41.7 | 41.7 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2272 | 1516 | 1516.0 | 38.4 | 38.4 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2273 | 3032 | 1516.0 | 71.1 | 35.5 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
| 2274 | 3031 | 1515.5 | 95.2 | 47.6 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Backhed | Nature | 2012 | 22972297 | No |
| 2275 | 1515 | 1515.0 | 61.2 | 61.2 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | No |
| 2276 | 3028 | 1514.0 | 58.5 | 29.2 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 2277 | 1514 | 1514.0 | 46.8 | 46.8 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
| 2278 | 4542 | 1514.0 | 148.8 | 49.6 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2279 | 3028 | 1514.0 | 98.6 | 49.3 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | No |
| 2280 | 3026 | 1513.0 | 98.9 | 49.5 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2281 | 3026 | 1513.0 | 100.4 | 50.2 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2282 | 3024 | 1512.0 | 56.4 | 28.2 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 2283 | 1511 | 1511.0 | 28.9 | 28.9 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 2284 | 1511 | 1511.0 | 72.5 | 72.5 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2285 | 1510 | 1510.0 | 49.3 | 49.3 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
| 2286 | 1510 | 1510.0 | 63.3 | 63.3 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2287 | 1510 | 1510.0 | 33.5 | 33.5 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2288 | 3020 | 1510.0 | 75.7 | 37.9 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 2289 | 3019 | 1509.5 | 56.8 | 28.4 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 2290 | 1509 | 1509.0 | 40.4 | 40.4 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
| 2291 | 1509 | 1509.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B MOUNTCASTLE | J Neurophysiol | 1957 | 13439410 | Yes |
| 2292 | 1509 | 1509.0 | 40.2 | 40.2 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
| 2293 | 1508 | 1508.0 | 34.4 | 34.4 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
| 2294 | 3016 | 1508.0 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F WROBLEWSKI, J S LADUE | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2295 | 1507 | 1507.0 | 44.9 | 44.9 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
| 2296 | 1507 | 1507.0 | 42.7 | 42.7 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2297 | 1506 | 1506.0 | 30.6 | 30.6 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
| 2298 | 1506 | 1506.0 | 38.3 | 38.3 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 2299 | 1506 | 1506.0 | 43.8 | 43.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 2300 | 1505 | 1505.0 | 17.9 | 17.9 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 2301 | 1505 | 1505.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2302 | 1504 | 1504.0 | 36.9 | 36.9 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
| 2303 | 1503 | 1503.0 | 52.0 | 52.0 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
| 2304 | 1503 | 1503.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2305 | 3005 | 1502.5 | 69.6 | 34.8 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2306 | 1502 | 1502.0 | 32.7 | 32.7 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 2307 | 1502 | 1502.0 | 25.5 | 25.5 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
| 2308 | 1502 | 1502.0 | 8.0 | 8.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W SPERRY | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2309 | 1502 | 1502.0 | 43.7 | 43.7 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2310 | 1501 | 1501.0 | 43.2 | 43.2 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
| 2311 | 1500 | 1500.0 | 46.8 | 46.8 | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. | Tristan Ian Croll | Acta Crystallogr D Struct Biol | 2018 | 29872003 | Yes |
| 2312 | 2999 | 1499.5 | 77.6 | 38.8 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 2313 | 2998 | 1499.0 | 67.7 | 33.9 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
| 2314 | 2997 | 1498.5 | 89.4 | 44.7 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2315 | 1498 | 1498.0 | 53.5 | 53.5 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2316 | 1498 | 1498.0 | 50.3 | 50.3 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2317 | 7486 | 1497.2 | 172.3 | 34.5 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2318 | 1497 | 1497.0 | 38.4 | 38.4 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
| 2319 | 1497 | 1497.0 | 36.6 | 36.6 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2320 | 1497 | 1497.0 | 51.4 | 51.4 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2321 | 1496 | 1496.0 | 52.5 | 52.5 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2322 | 1495 | 1495.0 | 36.0 | 36.0 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
| 2323 | 1495 | 1495.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E SATTERTHWAITE | Biometrics | 1946 | 20287815 | Yes |
| 2324 | 2990 | 1495.0 | 82.3 | 41.1 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
| 2325 | 1494 | 1494.0 | 40.8 | 40.8 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Domling | Chem Rev | 2006 | 16402771 | No |
| 2326 | 2987 | 1493.5 | 75.4 | 37.7 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2327 | 2985 | 1492.5 | 78.5 | 39.2 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
| 2328 | 1492 | 1492.0 | 33.8 | 33.8 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 2329 | 1492 | 1492.0 | 39.0 | 39.0 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 2330 | 2984 | 1492.0 | 93.7 | 46.9 | MissForest--non-parametric missing value imputation for mixed-type data. | Daniel J Stekhoven, Peter Buhlmann | Bioinformatics | 2012 | 22039212 | Yes |
| 2331 | 2983 | 1491.5 | 99.8 | 49.9 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
| 2332 | 1491 | 1491.0 | 39.2 | 39.2 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 2333 | 1491 | 1491.0 | 54.8 | 54.8 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2334 | 4472 | 1490.7 | 133.3 | 44.4 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | No |
| 2335 | 4472 | 1490.7 | 45.9 | 15.3 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T DODGE, C MITCHELL, D J HANAHAN | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2336 | 8942 | 1490.3 | 317.2 | 52.9 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2337 | 4471 | 1490.3 | 186.0 | 62.0 | Hepatocellular carcinoma. | Alejandro Forner, Maria Reig, Jordi Bruix | Lancet | 2018 | 29307467 | No |
| 2338 | 1488 | 1488.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2339 | 1488 | 1488.0 | 34.1 | 34.1 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
| 2340 | 2976 | 1488.0 | 115.1 | 57.5 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 2341 | 1487 | 1487.0 | 40.4 | 40.4 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
| 2342 | 1487 | 1487.0 | 30.5 | 30.5 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
| 2343 | 4460 | 1486.7 | 96.0 | 32.0 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2344 | 1486 | 1486.0 | 34.8 | 34.8 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2345 | 5944 | 1486.0 | 248.6 | 62.1 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2346 | 1486 | 1486.0 | 43.0 | 43.0 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
| 2347 | 1486 | 1486.0 | 26.3 | 26.3 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2348 | 1486 | 1486.0 | 33.2 | 33.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2349 | 1486 | 1486.0 | 38.9 | 38.9 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2350 | 13372 | 1485.8 | 409.9 | 45.5 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2351 | 7426 | 1485.2 | 267.2 | 53.4 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2352 | 1485 | 1485.0 | 31.6 | 31.6 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
| 2353 | 2969 | 1484.5 | 92.2 | 46.1 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
| 2354 | 2969 | 1484.5 | 103.4 | 51.7 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2355 | 1484 | 1484.0 | 35.3 | 35.3 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2356 | 1484 | 1484.0 | 53.5 | 53.5 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2357 | 1484 | 1484.0 | 31.8 | 31.8 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
| 2358 | 2966 | 1483.0 | 153.9 | 77.0 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2359 | 2966 | 1483.0 | 63.6 | 31.8 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
| 2360 | 1483 | 1483.0 | 61.5 | 61.5 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | No |
| 2361 | 8894 | 1482.3 | 301.9 | 50.3 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 2362 | 1482 | 1482.0 | 95.1 | 95.1 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2363 | 1482 | 1482.0 | 10.7 | 10.7 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E HUXLEY | J Mol Biol | 1963 | 14064165 | Yes |
| 2364 | 2962 | 1481.0 | 96.2 | 48.1 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2365 | 1481 | 1481.0 | 30.8 | 30.8 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2366 | 2962 | 1481.0 | 67.9 | 34.0 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
| 2367 | 1480 | 1480.0 | 33.6 | 33.6 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 2368 | 2959 | 1479.5 | 120.4 | 60.2 | AMPK: guardian of metabolism and mitochondrial homeostasis. | Sebastien Herzig, Reuben J Shaw | Nat Rev Mol Cell Biol | 2018 | 28974774 | No |
| 2369 | 2958 | 1479.0 | 76.0 | 38.0 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
| 2370 | 1479 | 1479.0 | 81.9 | 81.9 | Head and Neck Cancer. | Laura Q M Chow | N Engl J Med | 2020 | 31893516 | No |
| 2371 | 2956 | 1478.0 | 67.9 | 34.0 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
| 2372 | 1478 | 1478.0 | 34.3 | 34.3 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C NOWELL | Cancer Res | 1960 | 14427849 | Yes |
| 2373 | 2955 | 1477.5 | 82.1 | 41.0 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2374 | 1477 | 1477.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H ROSEN | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2375 | 1477 | 1477.0 | 36.6 | 36.6 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
| 2376 | 1477 | 1477.0 | 97.7 | 97.7 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
| 2377 | 1476 | 1476.0 | 43.6 | 43.6 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2378 | 1475 | 1475.0 | 45.0 | 45.0 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | No |
| 2379 | 2950 | 1475.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2380 | 1475 | 1475.0 | 57.3 | 57.3 | Diagnostic and Statistical Manual of Mental Disorders (DSM). | Dolores Elaine Battle | Codas | 2013 | 24413388 | Yes |
| 2381 | 2949 | 1474.5 | 97.7 | 48.9 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2382 | 2948 | 1474.0 | 54.2 | 27.1 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 2383 | 1474 | 1474.0 | 29.7 | 29.7 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2384 | 1474 | 1474.0 | 38.3 | 38.3 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2385 | 2948 | 1474.0 | 157.8 | 78.9 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G GRAY, V P WHITTAKER | J Anat | 1962 | 13901297 | Yes |
| 2386 | 2948 | 1474.0 | 105.9 | 53.0 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 2387 | 1474 | 1474.0 | 39.7 | 39.7 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | No |
| 2388 | 1474 | 1474.0 | 57.8 | 57.8 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
| 2389 | 1473 | 1473.0 | 36.5 | 36.5 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
| 2390 | 1473 | 1473.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F ROSENBLATT | Psychol Rev | 1958 | 13602029 | Yes |
| 2391 | 2946 | 1473.0 | 55.2 | 27.6 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
| 2392 | 1473 | 1473.0 | 55.3 | 55.3 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2393 | 2945 | 1472.5 | 78.0 | 39.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2394 | 7362 | 1472.4 | 275.7 | 55.1 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2395 | 4416 | 1472.0 | 93.3 | 31.1 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2396 | 1472 | 1472.0 | 29.1 | 29.1 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2397 | 7358 | 1471.6 | 366.7 | 73.3 | Standards for reporting qualitative research: a synthesis of recommendations. | Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook | Acad Med | 2014 | 24979285 | Yes |
| 2398 | 1471 | 1471.0 | 38.0 | 38.0 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2399 | 2941 | 1470.5 | 57.9 | 28.9 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2400 | 4411 | 1470.3 | 94.7 | 31.6 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornoe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2401 | 1470 | 1470.0 | 47.8 | 47.8 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2402 | 1470 | 1470.0 | 34.9 | 34.9 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
| 2403 | 2940 | 1470.0 | 90.7 | 45.4 | CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. | Jing Huang, Alexander D MacKerell | J Comput Chem | 2013 | 23832629 | Yes |
| 2404 | 10284 | 1469.1 | 406.4 | 58.1 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2405 | 1469 | 1469.0 | 25.8 | 25.8 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
| 2406 | 2937 | 1468.5 | 66.8 | 33.4 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
| 2407 | 2937 | 1468.5 | 100.4 | 50.2 | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. | Christoph Hafemeister, Rahul Satija | Genome Biol | 2019 | 31870423 | Yes |
| 2408 | 1467 | 1467.0 | 47.3 | 47.3 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2409 | 1467 | 1467.0 | 85.6 | 85.6 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2410 | 2934 | 1467.0 | 76.3 | 38.1 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2411 | 1467 | 1467.0 | 41.7 | 41.7 | Function and information content of DNA methylation. | Dirk Schubeler | Nature | 2015 | 25592537 | No |
| 2412 | 2933 | 1466.5 | 63.2 | 31.6 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2413 | 4398 | 1466.0 | 109.4 | 36.5 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2414 | 4397 | 1465.7 | 157.6 | 52.5 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 2415 | 2931 | 1465.5 | 117.6 | 58.8 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2416 | 2931 | 1465.5 | 54.6 | 27.3 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 2417 | 1465 | 1465.0 | 47.5 | 47.5 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | No |
| 2418 | 1465 | 1465.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2419 | 4394 | 1464.7 | 86.6 | 28.9 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
| 2420 | 4393 | 1464.3 | 150.6 | 50.2 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2421 | 4392 | 1464.0 | 92.4 | 30.8 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
| 2422 | 1464 | 1464.0 | 32.7 | 32.7 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J KARNOVSKY | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2423 | 1463 | 1463.0 | 20.9 | 20.9 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2424 | 1463 | 1463.0 | 34.3 | 34.3 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2425 | 2926 | 1463.0 | 85.2 | 42.6 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2426 | 1463 | 1463.0 | 39.9 | 39.9 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2427 | 1463 | 1463.0 | 68.1 | 68.1 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 2428 | 2925 | 1462.5 | 105.7 | 52.9 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
| 2429 | 2924 | 1462.0 | 71.5 | 35.8 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2430 | 2924 | 1462.0 | 81.3 | 40.6 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluisio J D Barros, Vania N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2431 | 1462 | 1462.0 | 32.8 | 32.8 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
| 2432 | 2923 | 1461.5 | 62.6 | 31.3 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
| 2433 | 2923 | 1461.5 | 68.4 | 34.2 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 2434 | 2922 | 1461.0 | 85.8 | 42.9 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
| 2435 | 1461 | 1461.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E BUSH | Biochem J | 1952 | 14915960 | Yes |
| 2436 | 7305 | 1461.0 | 204.7 | 40.9 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2437 | 23376 | 1461.0 | 621.4 | 38.8 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | No |
| 2438 | 5844 | 1461.0 | 205.9 | 51.5 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2439 | 4381 | 1460.3 | 89.3 | 29.8 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
| 2440 | 4379 | 1459.7 | 269.5 | 89.8 | Correlation Coefficients: Appropriate Use and Interpretation. | Patrick Schober, Christa Boer, Lothar A Schwarte | Anesth Analg | 2018 | 29481436 | No |
| 2441 | 2918 | 1459.0 | 99.8 | 49.9 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2442 | 1459 | 1459.0 | 31.4 | 31.4 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
| 2443 | 2918 | 1459.0 | 71.7 | 35.9 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
| 2444 | 1459 | 1459.0 | 42.2 | 42.2 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2445 | 1458 | 1458.0 | 55.7 | 55.7 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | No |
| 2446 | 4373 | 1457.7 | 134.1 | 44.7 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2447 | 1457 | 1457.0 | 33.5 | 33.5 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
| 2448 | 1457 | 1457.0 | 27.6 | 27.6 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
| 2449 | 2913 | 1456.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H CLARKE, J CASALS | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2450 | 1456 | 1456.0 | 40.2 | 40.2 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2451 | 1456 | 1456.0 | 41.4 | 41.4 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2452 | 2911 | 1455.5 | 84.8 | 42.4 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2453 | 5822 | 1455.5 | 239.2 | 59.8 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 2454 | 2910 | 1455.0 | 72.2 | 36.1 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2455 | 1455 | 1455.0 | 35.7 | 35.7 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2456 | 1455 | 1455.0 | 29.1 | 29.1 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
| 2457 | 2910 | 1455.0 | 80.0 | 40.0 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2458 | 1455 | 1455.0 | 55.7 | 55.7 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A de Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 2459 | 4363 | 1454.3 | 133.8 | 44.6 | Mendelian randomization analysis with multiple genetic variants using summarized data. | Stephen Burgess, Adam Butterworth, Simon G Thompson | Genet Epidemiol | 2013 | 24114802 | Yes |
| 2460 | 4362 | 1454.0 | 115.3 | 38.4 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2461 | 2908 | 1454.0 | 52.6 | 26.3 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 2462 | 2906 | 1453.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A ISAACS, J LINDENMANN | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2463 | 2906 | 1453.0 | 37.0 | 18.5 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A DAHLSTROEM, K FUXE | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2464 | 1453 | 1453.0 | 40.8 | 40.8 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2465 | 2904 | 1452.0 | 79.5 | 39.8 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2466 | 2904 | 1452.0 | 66.2 | 33.1 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gokhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
| 2467 | 1451 | 1451.0 | 31.0 | 31.0 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2468 | 8703 | 1450.5 | 213.5 | 35.6 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2469 | 1450 | 1450.0 | 34.9 | 34.9 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2470 | 1450 | 1450.0 | 36.7 | 36.7 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | No |
| 2471 | 2899 | 1449.5 | 78.2 | 39.1 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
| 2472 | 1449 | 1449.0 | 48.3 | 48.3 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2473 | 1449 | 1449.0 | 33.2 | 33.2 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | No |
| 2474 | 1449 | 1449.0 | 35.7 | 35.7 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
| 2475 | 1449 | 1449.0 | 69.5 | 69.5 | SARS-CoV-2 vaccines in development. | Florian Krammer | Nature | 2020 | 32967006 | No |
| 2476 | 4345 | 1448.3 | 108.8 | 36.3 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
| 2477 | 2896 | 1448.0 | 70.3 | 35.1 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2478 | 2896 | 1448.0 | 65.5 | 32.8 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2479 | 1448 | 1448.0 | 43.1 | 43.1 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2480 | 1448 | 1448.0 | 33.4 | 33.4 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
| 2481 | 4342 | 1447.3 | 203.7 | 67.9 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2482 | 5788 | 1447.0 | 153.6 | 38.4 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2483 | 1447 | 1447.0 | 30.7 | 30.7 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
| 2484 | 7233 | 1446.6 | 155.0 | 31.0 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2485 | 1446 | 1446.0 | 0.0 | 0.0 | The critical incident technique. | J C FLANAGAN | Psychol Bull | 1954 | 13177800 | Yes |
| 2486 | 2891 | 1445.5 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J BLOOM, W W RICHARDSON | Br J Cancer | 1957 | 13499785 | Yes |
| 2487 | 2891 | 1445.5 | 59.4 | 29.7 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 2488 | 1445 | 1445.0 | 17.1 | 17.1 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2489 | 2890 | 1445.0 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D DAVIS, E S MINGIOLI | J Bacteriol | 1950 | 15436457 | Yes |
| 2490 | 1445 | 1445.0 | 45.2 | 45.2 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2491 | 4335 | 1445.0 | 112.0 | 37.3 | Nitric oxide and peroxynitrite in health and disease. | Pal Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
| 2492 | 4333 | 1444.3 | 86.5 | 28.8 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
| 2493 | 1444 | 1444.0 | 84.4 | 84.4 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
| 2494 | 2887 | 1443.5 | 85.3 | 42.6 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2495 | 1443 | 1443.0 | 36.9 | 36.9 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 2496 | 1443 | 1443.0 | 67.4 | 67.4 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2497 | 1443 | 1443.0 | 26.6 | 26.6 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
| 2498 | 2886 | 1443.0 | 70.1 | 35.0 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2499 | 2884 | 1442.0 | 71.4 | 35.7 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2500 | 1442 | 1442.0 | 46.5 | 46.5 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | No |
| 2501 | 2882 | 1441.0 | 77.4 | 38.7 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
| 2502 | 2881 | 1440.5 | 70.1 | 35.0 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2503 | 1440 | 1440.0 | 30.9 | 30.9 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2504 | 1440 | 1440.0 | 38.5 | 38.5 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2505 | 2880 | 1440.0 | 66.4 | 33.2 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
| 2506 | 2880 | 1440.0 | 174.2 | 87.1 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H ANTON, D F SAYRE | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2507 | 1439 | 1439.0 | 29.2 | 29.2 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2508 | 1439 | 1439.0 | 54.3 | 54.3 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2509 | 1439 | 1439.0 | 34.4 | 34.4 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
| 2510 | 1439 | 1439.0 | 31.9 | 31.9 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2511 | 1439 | 1439.0 | 50.7 | 50.7 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2512 | 4316 | 1438.7 | 93.0 | 31.0 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
| 2513 | 1438 | 1438.0 | 50.4 | 50.4 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2514 | 8626 | 1437.7 | 207.8 | 34.6 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2515 | 4312 | 1437.3 | 99.5 | 33.2 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2516 | 1437 | 1437.0 | 35.2 | 35.2 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2517 | 1437 | 1437.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D POULIK | Nature | 1957 | 13493570 | Yes |
| 2518 | 1437 | 1437.0 | 29.6 | 29.6 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2519 | 1437 | 1437.0 | 39.1 | 39.1 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2520 | 1436 | 1436.0 | 40.3 | 40.3 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
| 2521 | 1436 | 1436.0 | 16.7 | 16.7 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J WYMAN | Adv Protein Chem | 1964 | 14268785 | No |
| 2522 | 1436 | 1436.0 | 32.9 | 32.9 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2523 | 1435 | 1435.0 | 58.6 | 58.6 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2524 | 1435 | 1435.0 | 49.1 | 49.1 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | No |
| 2525 | 1434 | 1434.0 | 49.1 | 49.1 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | No |
| 2526 | 1433 | 1433.0 | 29.3 | 29.3 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2527 | 2866 | 1433.0 | 68.2 | 34.1 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2528 | 1433 | 1433.0 | 43.3 | 43.3 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2529 | 1433 | 1433.0 | 12.9 | 12.9 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2530 | 1433 | 1433.0 | 44.2 | 44.2 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2531 | 2865 | 1432.5 | 66.4 | 33.2 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
| 2532 | 5729 | 1432.2 | 192.2 | 48.0 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2533 | 1432 | 1432.0 | 46.1 | 46.1 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2534 | 1432 | 1432.0 | 36.4 | 36.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2535 | 1432 | 1432.0 | 52.8 | 52.8 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | No |
| 2536 | 5727 | 1431.8 | 149.5 | 37.4 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2537 | 4293 | 1431.0 | 139.7 | 46.6 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2538 | 2862 | 1431.0 | 83.0 | 41.5 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
| 2539 | 1431 | 1431.0 | 26.9 | 26.9 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
| 2540 | 2862 | 1431.0 | 114.7 | 57.4 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 2541 | 1430 | 1430.0 | 33.0 | 33.0 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 2542 | 1430 | 1430.0 | 28.0 | 28.0 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2543 | 2860 | 1430.0 | 58.1 | 29.1 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2544 | 1430 | 1430.0 | 49.9 | 49.9 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | No |
| 2545 | 2860 | 1430.0 | 143.8 | 71.9 | Depression. | Gin S Malhi, J John Mann | Lancet | 2018 | 30396512 | No |
| 2546 | 2857 | 1428.5 | 81.3 | 40.6 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2547 | 1428 | 1428.0 | 28.0 | 28.0 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 2548 | 1428 | 1428.0 | 40.4 | 40.4 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
| 2549 | 14278 | 1427.8 | 523.6 | 52.4 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 2550 | 2855 | 1427.5 | 77.4 | 38.7 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
| 2551 | 8564 | 1427.3 | 220.9 | 36.8 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2552 | 1427 | 1427.0 | 37.0 | 37.0 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
| 2553 | 2854 | 1427.0 | 54.9 | 27.4 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
| 2554 | 2854 | 1427.0 | 66.7 | 33.4 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
| 2555 | 2854 | 1427.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L HODGKIN, B KATZ | J Physiol | 1949 | 18128147 | Yes |
| 2556 | 1427 | 1427.0 | 41.7 | 41.7 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | No |
| 2557 | 2852 | 1426.0 | 68.6 | 34.3 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | No |
| 2558 | 2851 | 1425.5 | 95.9 | 48.0 | A new scale of social desirability independent of psychopathology. | D P CROWNE, D MARLOWE | J Consult Psychol | 1960 | 13813058 | Yes |
| 2559 | 2850 | 1425.0 | 69.4 | 34.7 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
| 2560 | 2849 | 1424.5 | 88.7 | 44.4 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2561 | 1424 | 1424.0 | 24.3 | 24.3 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
| 2562 | 2847 | 1423.5 | 74.0 | 37.0 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 2563 | 2846 | 1423.0 | 83.1 | 41.5 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2564 | 7114 | 1422.8 | 249.3 | 49.9 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2565 | 2844 | 1422.0 | 106.4 | 53.2 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2566 | 1422 | 1422.0 | 31.4 | 31.4 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
| 2567 | 1422 | 1422.0 | 32.3 | 32.3 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2568 | 4266 | 1422.0 | 117.2 | 39.1 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2569 | 1422 | 1422.0 | 39.4 | 39.4 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
| 2570 | 5685 | 1421.2 | 195.2 | 48.8 | MultiQC: summarize analysis results for multiple tools and samples in a single report. | Philip Ewels, Mans Magnusson, Sverker Lundin, Max Kaller | Bioinformatics | 2016 | 27312411 | Yes |
| 2571 | 1421 | 1421.0 | 41.5 | 41.5 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
| 2572 | 2842 | 1421.0 | 97.4 | 48.7 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | No |
| 2573 | 1420 | 1420.0 | 36.1 | 36.1 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2574 | 2839 | 1419.5 | 107.1 | 53.5 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2575 | 17031 | 1419.2 | 1163.0 | 96.9 | The REDCap consortium: Building an international community of software platform partners. | Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, | J Biomed Inform | 2019 | 31078660 | Yes |
| 2576 | 1419 | 1419.0 | 25.3 | 25.3 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
| 2577 | 1419 | 1419.0 | 28.9 | 28.9 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
| 2578 | 1419 | 1419.0 | 35.4 | 35.4 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2579 | 2836 | 1418.0 | 172.1 | 86.0 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2580 | 1418 | 1418.0 | 33.2 | 33.2 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 2581 | 1418 | 1418.0 | 66.8 | 66.8 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | No |
| 2582 | 1417 | 1417.0 | 50.6 | 50.6 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
| 2583 | 1417 | 1417.0 | 24.6 | 24.6 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2584 | 1417 | 1417.0 | 31.1 | 31.1 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
| 2585 | 2834 | 1417.0 | 69.1 | 34.5 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2586 | 2831 | 1415.5 | 64.1 | 32.0 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
| 2587 | 2830 | 1415.0 | 82.5 | 41.2 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2588 | 1415 | 1415.0 | 31.9 | 31.9 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
| 2589 | 1415 | 1415.0 | 47.9 | 47.9 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2590 | 1415 | 1415.0 | 29.0 | 29.0 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
| 2591 | 1415 | 1415.0 | 29.1 | 29.1 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
| 2592 | 5660 | 1415.0 | 142.9 | 35.7 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw, | Lancet | 2005 | 16182882 | Yes |
| 2593 | 1414 | 1414.0 | 43.5 | 43.5 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2594 | 4242 | 1414.0 | 80.1 | 26.7 | Exosomes: composition, biogenesis and function. | Clotilde Thery, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
| 2595 | 5656 | 1414.0 | 141.2 | 35.3 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2596 | 2826 | 1413.0 | 98.7 | 49.4 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2597 | 1413 | 1413.0 | 30.9 | 30.9 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
| 2598 | 1412 | 1412.0 | 35.2 | 35.2 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
| 2599 | 2823 | 1411.5 | 71.1 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2600 | 1411 | 1411.0 | 44.8 | 44.8 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 2601 | 1411 | 1411.0 | 34.2 | 34.2 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2602 | 1411 | 1411.0 | 25.1 | 25.1 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
| 2603 | 2821 | 1410.5 | 42.3 | 21.1 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2604 | 2820 | 1410.0 | 95.1 | 47.5 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
| 2605 | 1410 | 1410.0 | 15.3 | 15.3 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | No |
| 2606 | 1410 | 1410.0 | 25.8 | 25.8 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
| 2607 | 7048 | 1409.6 | 130.7 | 26.1 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mader, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2608 | 2819 | 1409.5 | 81.6 | 40.8 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
| 2609 | 1409 | 1409.0 | 32.6 | 32.6 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
| 2610 | 1409 | 1409.0 | 38.4 | 38.4 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | No |
| 2611 | 2818 | 1409.0 | 120.1 | 60.0 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | No |
| 2612 | 2817 | 1408.5 | 62.6 | 31.3 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2613 | 16896 | 1408.0 | 420.4 | 35.0 | Frailty in older adults: evidence for a phenotype. | L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, | J Gerontol A Biol Sci Med Sci | 2001 | 11253156 | Yes |
| 2614 | 2816 | 1408.0 | 61.8 | 30.9 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
| 2615 | 4223 | 1407.7 | 93.9 | 31.3 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2616 | 2815 | 1407.5 | 128.5 | 64.2 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2617 | 9852 | 1407.4 | 286.2 | 40.9 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2618 | 1407 | 1407.0 | 32.5 | 32.5 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2619 | 2813 | 1406.5 | 85.3 | 42.6 | Liquid phase condensation in cell physiology and disease. | Yongdae Shin, Clifford P Brangwynne | Science | 2017 | 28935776 | No |
| 2620 | 1406 | 1406.0 | 40.7 | 40.7 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
| 2621 | 4218 | 1406.0 | 83.9 | 28.0 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
| 2622 | 1406 | 1406.0 | 64.6 | 64.6 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 2623 | 4217 | 1405.7 | 95.9 | 32.0 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2624 | 2811 | 1405.5 | 71.1 | 35.5 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2625 | 1405 | 1405.0 | 20.7 | 20.7 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2626 | 1405 | 1405.0 | 28.0 | 28.0 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Sudhof | Nature | 2008 | 18923512 | No |
| 2627 | 2809 | 1404.5 | 62.1 | 31.1 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2628 | 1404 | 1404.0 | 43.1 | 43.1 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
| 2629 | 2808 | 1404.0 | 51.8 | 25.9 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 2630 | 2807 | 1403.5 | 71.7 | 35.9 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2631 | 4209 | 1403.0 | 106.0 | 35.3 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2632 | 1402 | 1402.0 | 39.0 | 39.0 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2633 | 2803 | 1401.5 | 86.4 | 43.2 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2634 | 1401 | 1401.0 | 22.1 | 22.1 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 2635 | 2802 | 1401.0 | 61.7 | 30.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2636 | 1401 | 1401.0 | 34.4 | 34.4 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
| 2637 | 1400 | 1400.0 | 31.4 | 31.4 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
| 2638 | 2798 | 1399.0 | 101.7 | 50.9 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | No |
| 2639 | 1398 | 1398.0 | 73.1 | 73.1 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2640 | 1398 | 1398.0 | 29.6 | 29.6 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
| 2641 | 1398 | 1398.0 | 35.2 | 35.2 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
| 2642 | 4193 | 1397.7 | 119.4 | 39.8 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 2643 | 5589 | 1397.2 | 261.5 | 65.4 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 2644 | 2794 | 1397.0 | 60.6 | 30.3 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2645 | 2794 | 1397.0 | 83.3 | 41.6 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 2646 | 1397 | 1397.0 | 29.2 | 29.2 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 2647 | 1396 | 1396.0 | 40.8 | 40.8 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
| 2648 | 2792 | 1396.0 | 61.4 | 30.7 | Immunoassay of endogenous plasma insulin in man. | R S YALOW, S A BERSON | J Clin Invest | 1960 | 13846364 | Yes |
| 2649 | 1396 | 1396.0 | 43.1 | 43.1 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
| 2650 | 2791 | 1395.5 | 81.6 | 40.8 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P DOLE, H MEINERTZ | J Biol Chem | 1960 | 13817286 | Yes |
| 2651 | 2791 | 1395.5 | 59.7 | 29.9 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2652 | 6976 | 1395.2 | 181.1 | 36.2 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2653 | 2790 | 1395.0 | 101.2 | 50.6 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
| 2654 | 1395 | 1395.0 | 30.7 | 30.7 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
| 2655 | 1395 | 1395.0 | 26.2 | 26.2 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2656 | 1395 | 1395.0 | 36.6 | 36.6 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
| 2657 | 2788 | 1394.0 | 55.0 | 27.5 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 2658 | 1394 | 1394.0 | 25.6 | 25.6 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
| 2659 | 1394 | 1394.0 | 32.5 | 32.5 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabo | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2660 | 1394 | 1394.0 | 28.3 | 28.3 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 2661 | 4181 | 1393.7 | 90.9 | 30.3 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
| 2662 | 5574 | 1393.5 | 118.9 | 29.7 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2663 | 2787 | 1393.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J CRONBACH, P E MEEHL | Psychol Bull | 1955 | 13245896 | Yes |
| 2664 | 1393 | 1393.0 | 31.1 | 31.1 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
| 2665 | 1393 | 1393.0 | 32.1 | 32.1 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2666 | 1393 | 1393.0 | 40.6 | 40.6 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
| 2667 | 1392 | 1392.0 | 60.3 | 60.3 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2668 | 1392 | 1392.0 | 24.1 | 24.1 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
| 2669 | 6957 | 1391.4 | 213.4 | 42.7 | CD-HIT: accelerated for clustering the next-generation sequencing data. | Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li | Bioinformatics | 2012 | 23060610 | Yes |
| 2670 | 1391 | 1391.0 | 29.6 | 29.6 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
| 2671 | 1391 | 1391.0 | 27.5 | 27.5 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
| 2672 | 1390 | 1390.0 | 11.0 | 11.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2673 | 2779 | 1389.5 | 98.9 | 49.5 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | No |
| 2674 | 2776 | 1388.0 | 55.3 | 27.6 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
| 2675 | 8324 | 1387.3 | 289.2 | 48.2 | Second-generation PLINK: rising to the challenge of larger and richer datasets. | Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee | Gigascience | 2015 | 25722852 | Yes |
| 2676 | 2774 | 1387.0 | 165.1 | 82.5 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2677 | 1387 | 1387.0 | 34.8 | 34.8 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2678 | 1387 | 1387.0 | 23.7 | 23.7 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
| 2679 | 1387 | 1387.0 | 36.8 | 36.8 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 2680 | 2773 | 1386.5 | 54.6 | 27.3 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2681 | 2773 | 1386.5 | 77.4 | 38.7 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M van der Bliek | Science | 2012 | 22936770 | No |
| 2682 | 1386 | 1386.0 | 28.4 | 28.4 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2683 | 1386 | 1386.0 | 36.1 | 36.1 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
| 2684 | 1386 | 1386.0 | 39.1 | 39.1 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2685 | 2772 | 1386.0 | 76.5 | 38.2 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 2686 | 2771 | 1385.5 | 71.2 | 35.6 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2687 | 2771 | 1385.5 | 77.0 | 38.5 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2688 | 2771 | 1385.5 | 73.5 | 36.8 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 2689 | 1385 | 1385.0 | 43.2 | 43.2 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2690 | 1385 | 1385.0 | 23.9 | 23.9 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2691 | 2769 | 1384.5 | 91.2 | 45.6 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | No |
| 2692 | 1384 | 1384.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M REITAN | J Consult Psychol | 1955 | 13263471 | Yes |
| 2693 | 1384 | 1384.0 | 50.0 | 50.0 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | No |
| 2694 | 1384 | 1384.0 | 45.5 | 45.5 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | No |
| 2695 | 1383 | 1383.0 | 49.6 | 49.6 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2696 | 8298 | 1383.0 | 203.7 | 33.9 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2697 | 1383 | 1383.0 | 35.4 | 35.4 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
| 2698 | 2764 | 1382.0 | 96.4 | 48.2 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2699 | 1382 | 1382.0 | 36.3 | 36.3 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | No |
| 2700 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C SCHNEIDER | J Biol Chem | 1948 | 18886166 | Yes |
| 2701 | 2763 | 1381.5 | 70.3 | 35.1 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2702 | 2762 | 1381.0 | 67.4 | 33.7 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2703 | 1381 | 1381.0 | 27.4 | 27.4 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
| 2704 | 4143 | 1381.0 | 216.2 | 72.1 | Improved metagenomic analysis with Kraken 2. | Derrick E Wood, Jennifer Lu, Ben Langmead | Genome Biol | 2019 | 31779668 | Yes |
| 2705 | 1380 | 1380.0 | 30.5 | 30.5 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2706 | 4139 | 1379.7 | 147.0 | 49.0 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2707 | 1379 | 1379.0 | 32.3 | 32.3 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2708 | 1379 | 1379.0 | 11.4 | 11.4 | Immunological function of the thymus. | J F MILLER | Lancet | 1961 | 14474038 | Yes |
| 2709 | 1379 | 1379.0 | 32.0 | 32.0 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
| 2710 | 1379 | 1379.0 | 65.8 | 65.8 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. | Nicholas A Meanwell | J Med Chem | 2018 | 29400967 | No |
| 2711 | 8273 | 1378.8 | 240.9 | 40.1 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 2712 | 4135 | 1378.3 | 85.0 | 28.3 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2713 | 4134 | 1378.0 | 100.2 | 33.4 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon, | J Thromb Haemost | 2005 | 15842354 | Yes |
| 2714 | 2755 | 1377.5 | 70.2 | 35.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wuthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2715 | 1377 | 1377.0 | 39.1 | 39.1 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2716 | 1377 | 1377.0 | 42.0 | 42.0 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2717 | 1377 | 1377.0 | 31.1 | 31.1 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
| 2718 | 1377 | 1377.0 | 33.3 | 33.3 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
| 2719 | 1376 | 1376.0 | 22.9 | 22.9 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
| 2720 | 1376 | 1376.0 | 45.9 | 45.9 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 2721 | 5501 | 1375.2 | 125.3 | 31.3 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2722 | 1375 | 1375.0 | 0.0 | 0.0 | On the psychophysical law. | S S STEVENS | Psychol Rev | 1957 | 13441853 | Yes |
| 2723 | 1374 | 1374.0 | 43.6 | 43.6 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
| 2724 | 2747 | 1373.5 | 80.2 | 40.1 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | No |
| 2725 | 1373 | 1373.0 | 47.1 | 47.1 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2726 | 2745 | 1372.5 | 54.2 | 27.1 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2727 | 1372 | 1372.0 | 32.7 | 32.7 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2728 | 2744 | 1372.0 | 150.2 | 75.1 | Sarcopenia. | Alfonso J Cruz-Jentoft, Avan A Sayer | Lancet | 2019 | 31171417 | No |
| 2729 | 2743 | 1371.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B CHANCE, G R WILLIAMS | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2730 | 5486 | 1371.5 | 105.7 | 26.4 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2731 | 2743 | 1371.5 | 78.8 | 39.4 | Opportunities and challenges for a sustainable energy future. | Steven Chu, Arun Majumdar | Nature | 2012 | 22895334 | No |
| 2732 | 8228 | 1371.3 | 227.0 | 37.8 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
| 2733 | 4113 | 1371.0 | 120.1 | 40.0 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2734 | 1371 | 1371.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W TUKEY | Biometrics | 1949 | 18151955 | Yes |
| 2735 | 1370 | 1370.0 | 35.8 | 35.8 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 2736 | 5479 | 1369.8 | 147.8 | 37.0 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 2737 | 2739 | 1369.5 | 53.7 | 26.9 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2738 | 2739 | 1369.5 | 56.2 | 28.1 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2739 | 1369 | 1369.0 | 46.2 | 46.2 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
| 2740 | 2738 | 1369.0 | 69.6 | 34.8 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2741 | 1369 | 1369.0 | 35.3 | 35.3 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
| 2742 | 1369 | 1369.0 | 36.0 | 36.0 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2743 | 2738 | 1369.0 | 66.4 | 33.2 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
| 2744 | 1369 | 1369.0 | 35.2 | 35.2 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
| 2745 | 1368 | 1368.0 | 27.3 | 27.3 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
| 2746 | 1368 | 1368.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B CLOWARD | J Neurosurg | 1958 | 13599052 | Yes |
| 2747 | 1368 | 1368.0 | 29.7 | 29.7 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2748 | 1368 | 1368.0 | 82.5 | 82.5 | COVID-19 and African Americans. | Clyde W Yancy | JAMA | 2020 | 32293639 | Yes |
| 2749 | 1367 | 1367.0 | 38.0 | 38.0 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 2750 | 1366 | 1366.0 | 47.2 | 47.2 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2751 | 1366 | 1366.0 | 27.0 | 27.0 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2752 | 1366 | 1366.0 | 33.7 | 33.7 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 2753 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O SMITHIES | Biochem J | 1959 | 13638269 | Yes |
| 2754 | 1366 | 1366.0 | 44.3 | 44.3 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 2755 | 1365 | 1365.0 | 45.1 | 45.1 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
| 2756 | 2729 | 1364.5 | 39.8 | 19.9 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2757 | 1364 | 1364.0 | 46.7 | 46.7 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2758 | 1364 | 1364.0 | 23.2 | 23.2 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2759 | 5456 | 1364.0 | 172.0 | 43.0 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2760 | 2728 | 1364.0 | 56.5 | 28.2 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
| 2761 | 2728 | 1364.0 | 103.5 | 51.8 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | No |
| 2762 | 5454 | 1363.5 | 116.1 | 29.0 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2763 | 1363 | 1363.0 | 29.7 | 29.7 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2764 | 4089 | 1363.0 | 98.7 | 32.9 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 2765 | 1363 | 1363.0 | 57.8 | 57.8 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | No |
| 2766 | 1362 | 1362.0 | 42.4 | 42.4 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
| 2767 | 1362 | 1362.0 | 28.5 | 28.5 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
| 2768 | 1361 | 1361.0 | 41.2 | 41.2 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
| 2769 | 2722 | 1361.0 | 52.5 | 26.2 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
| 2770 | 1361 | 1361.0 | 23.1 | 23.1 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 2771 | 4083 | 1361.0 | 90.7 | 30.2 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 2772 | 5443 | 1360.8 | 161.2 | 40.3 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | No |
| 2773 | 4081 | 1360.3 | 125.3 | 41.8 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2774 | 1360 | 1360.0 | 41.6 | 41.6 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
| 2775 | 2720 | 1360.0 | 72.1 | 36.0 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2776 | 1360 | 1360.0 | 57.8 | 57.8 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2777 | 1360 | 1360.0 | 43.2 | 43.2 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | No |
| 2778 | 2719 | 1359.5 | 46.9 | 23.4 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
| 2779 | 2719 | 1359.5 | 69.1 | 34.5 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2780 | 13593 | 1359.3 | 466.1 | 46.6 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | BMJ | 2009 | 19622552 | No |
| 2781 | 1359 | 1359.0 | 48.3 | 48.3 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
| 2782 | 1359 | 1359.0 | 28.5 | 28.5 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2783 | 5436 | 1359.0 | 124.3 | 31.1 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2784 | 1359 | 1359.0 | 39.6 | 39.6 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
| 2785 | 1359 | 1359.0 | 63.4 | 63.4 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 2786 | 4076 | 1358.7 | 127.8 | 42.6 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2787 | 1358 | 1358.0 | 43.1 | 43.1 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2788 | 4074 | 1358.0 | 93.9 | 31.3 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 2789 | 1358 | 1358.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B CAULFIELD | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2790 | 1357 | 1357.0 | 24.3 | 24.3 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 2791 | 1356 | 1356.0 | 63.4 | 63.4 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 2792 | 1356 | 1356.0 | 44.1 | 44.1 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | No |
| 2793 | 2711 | 1355.5 | 61.8 | 30.9 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 2794 | 2710 | 1355.0 | 120.7 | 60.4 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2795 | 2710 | 1355.0 | 61.1 | 30.6 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 2796 | 5420 | 1355.0 | 119.5 | 29.9 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2797 | 1355 | 1355.0 | 32.7 | 32.7 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2798 | 1355 | 1355.0 | 50.8 | 50.8 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 2799 | 5418 | 1354.5 | 301.5 | 75.4 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2800 | 2709 | 1354.5 | 134.8 | 67.4 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2801 | 2709 | 1354.5 | 64.1 | 32.0 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
| 2802 | 1354 | 1354.0 | 34.2 | 34.2 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
| 2803 | 1354 | 1354.0 | 25.7 | 25.7 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2804 | 1354 | 1354.0 | 44.2 | 44.2 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamas Roszer | Mediators Inflamm | 2015 | 26089604 | No |
| 2805 | 2707 | 1353.5 | 87.7 | 43.9 | Severe sepsis and septic shock. | Derek C Angus, Tom van der Poll | N Engl J Med | 2013 | 23984731 | No |
| 2806 | 4060 | 1353.3 | 49.5 | 16.5 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D SABATINI, K BENSCH, R J BARRNETT | J Cell Biol | 1963 | 13975866 | Yes |
| 2807 | 1353 | 1353.0 | 35.3 | 35.3 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
| 2808 | 1353 | 1353.0 | 33.5 | 33.5 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
| 2809 | 2706 | 1353.0 | 72.2 | 36.1 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
| 2810 | 1352 | 1352.0 | 23.3 | 23.3 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 2811 | 4056 | 1352.0 | 99.6 | 33.2 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2812 | 1352 | 1352.0 | 36.2 | 36.2 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
| 2813 | 2704 | 1352.0 | 58.8 | 29.4 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2814 | 2703 | 1351.5 | 85.4 | 42.7 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschope | J Am Coll Cardiol | 2013 | 23684677 | No |
| 2815 | 2702 | 1351.0 | 221.0 | 110.5 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2816 | 1351 | 1351.0 | 35.9 | 35.9 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | No |
| 2817 | 2701 | 1350.5 | 68.3 | 34.1 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
| 2818 | 5402 | 1350.5 | 232.5 | 58.1 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Goker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 2819 | 2700 | 1350.0 | 60.8 | 30.4 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2820 | 1350 | 1350.0 | 66.2 | 66.2 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2821 | 2700 | 1350.0 | 55.7 | 27.9 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 2822 | 1349 | 1349.0 | 16.9 | 16.9 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 2823 | 1349 | 1349.0 | 34.8 | 34.8 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2824 | 1349 | 1349.0 | 52.9 | 52.9 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | Yes |
| 2825 | 1349 | 1349.0 | 76.3 | 76.3 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 2826 | 2697 | 1348.5 | 57.4 | 28.7 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2827 | 1348 | 1348.0 | 44.0 | 44.0 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
| 2828 | 1348 | 1348.0 | 59.6 | 59.6 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 2829 | 1348 | 1348.0 | 67.1 | 67.1 | Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. | Dimitrios Tsikas | Anal Biochem | 2017 | 27789233 | No |
| 2830 | 12131 | 1347.9 | 291.5 | 32.4 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2831 | 1347 | 1347.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J WADDELL | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2832 | 5384 | 1346.0 | 147.0 | 36.8 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 2833 | 10765 | 1345.6 | 259.7 | 32.5 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2834 | 2691 | 1345.5 | 72.9 | 36.5 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
| 2835 | 2691 | 1345.5 | 75.0 | 37.5 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gokhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
| 2836 | 4035 | 1345.0 | 195.6 | 65.2 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2837 | 1345 | 1345.0 | 35.5 | 35.5 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
| 2838 | 1345 | 1345.0 | 30.3 | 30.3 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | No |
| 2839 | 2689 | 1344.5 | 86.5 | 43.2 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2840 | 1344 | 1344.0 | 59.8 | 59.8 | Body Mass Index: Obesity, BMI, and Health: A Critical Review. | Frank Q Nuttall | Nutr Today | 2015 | 27340299 | Yes |
| 2841 | 1343 | 1343.0 | 51.7 | 51.7 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2842 | 1343 | 1343.0 | 32.5 | 32.5 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2843 | 1343 | 1343.0 | 43.8 | 43.8 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | No |
| 2844 | 2685 | 1342.5 | 44.7 | 22.4 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
| 2845 | 2685 | 1342.5 | 65.5 | 32.8 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 2846 | 2685 | 1342.5 | 60.3 | 30.1 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 2847 | 1342 | 1342.0 | 46.8 | 46.8 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2848 | 1342 | 1342.0 | 27.2 | 27.2 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
| 2849 | 2683 | 1341.5 | 73.8 | 36.9 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | No |
| 2850 | 4023 | 1341.0 | 83.8 | 27.9 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 2851 | 2682 | 1341.0 | 62.1 | 31.1 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2852 | 1341 | 1341.0 | 54.2 | 54.2 | Overview of the IL-1 family in innate inflammation and acquired immunity. | Charles A Dinarello | Immunol Rev | 2018 | 29247995 | No |
| 2853 | 1340 | 1340.0 | 27.7 | 27.7 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2854 | 1340 | 1340.0 | 63.2 | 63.2 | Cellular resistance to infection. | G B MACKANESS | J Exp Med | 1962 | 14467923 | Yes |
| 2855 | 2680 | 1340.0 | 93.2 | 46.6 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Thery | Cell | 2016 | 26967288 | No |
| 2856 | 2679 | 1339.5 | 74.0 | 37.0 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 2857 | 1339 | 1339.0 | 34.9 | 34.9 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2858 | 1339 | 1339.0 | 45.2 | 45.2 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
| 2859 | 1339 | 1339.0 | 55.2 | 55.2 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2860 | 4014 | 1338.0 | 120.7 | 40.2 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2861 | 1338 | 1338.0 | 24.6 | 24.6 | A modified procedure for lead staining of thin sections. | G MILLONIG | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2862 | 1338 | 1338.0 | 32.0 | 32.0 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2863 | 1337 | 1337.0 | 55.5 | 55.5 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2864 | 1337 | 1337.0 | 32.6 | 32.6 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2865 | 1337 | 1337.0 | 29.9 | 29.9 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2866 | 2673 | 1336.5 | 58.0 | 29.0 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
| 2867 | 4009 | 1336.3 | 94.8 | 31.6 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2868 | 1336 | 1336.0 | 24.6 | 24.6 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
| 2869 | 1336 | 1336.0 | 46.2 | 46.2 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 2870 | 1336 | 1336.0 | 33.5 | 33.5 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 2871 | 1336 | 1336.0 | 34.9 | 34.9 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
| 2872 | 1336 | 1336.0 | 30.2 | 30.2 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | No |
| 2873 | 5343 | 1335.8 | 133.2 | 33.3 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2874 | 1335 | 1335.0 | 47.5 | 47.5 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | No |
| 2875 | 2670 | 1335.0 | 49.5 | 24.8 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2876 | 2670 | 1335.0 | 79.5 | 39.8 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2877 | 1335 | 1335.0 | 33.5 | 33.5 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2878 | 1335 | 1335.0 | 35.3 | 35.3 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2879 | 2670 | 1335.0 | 57.1 | 28.6 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2880 | 2669 | 1334.5 | 64.3 | 32.1 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2881 | 2669 | 1334.5 | 52.2 | 26.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
| 2882 | 1334 | 1334.0 | 50.7 | 50.7 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
| 2883 | 1334 | 1334.0 | 61.1 | 61.1 | Embracing the unknown: disentangling the complexities of the soil microbiome. | Noah Fierer | Nat Rev Microbiol | 2017 | 28824177 | No |
| 2884 | 2667 | 1333.5 | 100.1 | 50.0 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2885 | 2666 | 1333.0 | 50.5 | 25.2 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2886 | 1333 | 1333.0 | 34.6 | 34.6 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
| 2887 | 1333 | 1333.0 | 30.0 | 30.0 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2888 | 1333 | 1333.0 | 37.7 | 37.7 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2889 | 3997 | 1332.3 | 92.2 | 30.7 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Ronnback, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | No |
| 2890 | 2664 | 1332.0 | 78.4 | 39.2 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
| 2891 | 1332 | 1332.0 | 24.7 | 24.7 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2892 | 1332 | 1332.0 | 29.8 | 29.8 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 2893 | 2664 | 1332.0 | 58.2 | 29.1 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P van den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 2894 | 1332 | 1332.0 | 45.1 | 45.1 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | No |
| 2895 | 2663 | 1331.5 | 80.1 | 40.0 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | No |
| 2896 | 1331 | 1331.0 | 56.0 | 56.0 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2897 | 1331 | 1331.0 | 22.7 | 22.7 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 2898 | 1331 | 1331.0 | 26.9 | 26.9 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 2899 | 1331 | 1331.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A BERG | J Gen Psychol | 1948 | 18889466 | Yes |
| 2900 | 2662 | 1331.0 | 77.9 | 39.0 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | No |
| 2901 | 1331 | 1331.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J BERKSON | Biometrics | 1946 | 21001024 | Yes |
| 2902 | 5320 | 1330.0 | 129.6 | 32.4 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 2903 | 1330 | 1330.0 | 31.7 | 31.7 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2904 | 1330 | 1330.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2905 | 5319 | 1329.8 | 121.9 | 30.5 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar von Heijne, Soren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2906 | 2659 | 1329.5 | 91.1 | 45.5 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2907 | 2659 | 1329.5 | 55.2 | 27.6 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2908 | 2658 | 1329.0 | 59.9 | 29.9 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 2909 | 1329 | 1329.0 | 36.2 | 36.2 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2910 | 1329 | 1329.0 | 28.8 | 28.8 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
| 2911 | 2658 | 1329.0 | 67.4 | 33.7 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2912 | 2658 | 1329.0 | 68.4 | 34.2 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 2913 | 3983 | 1327.7 | 164.2 | 54.7 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 2914 | 2655 | 1327.5 | 45.9 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2915 | 1327 | 1327.0 | 21.9 | 21.9 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2916 | 1327 | 1327.0 | 35.6 | 35.6 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
| 2917 | 7958 | 1326.3 | 226.0 | 37.7 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 2918 | 1326 | 1326.0 | 38.1 | 38.1 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | No |
| 2919 | 1326 | 1326.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J BATEMAN | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2920 | 3977 | 1325.7 | 96.2 | 32.1 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 2921 | 14580 | 1325.5 | 398.3 | 36.2 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 2922 | 2650 | 1325.0 | 66.2 | 33.1 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2923 | 1325 | 1325.0 | 26.4 | 26.4 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
| 2924 | 2649 | 1324.5 | 64.9 | 32.5 | Interneurons of the hippocampus. | T F Freund, G Buzsaki | Hippocampus | 1996 | 8915675 | No |
| 2925 | 1324 | 1324.0 | 32.3 | 32.3 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
| 2926 | 2648 | 1324.0 | 59.7 | 29.9 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
| 2927 | 6619 | 1323.8 | 161.6 | 32.3 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 2928 | 2647 | 1323.5 | 116.7 | 58.4 | Inflammation and Cancer: Triggers, Mechanisms, and Consequences. | Florian R Greten, Sergei I Grivennikov | Immunity | 2019 | 31315034 | No |
| 2929 | 2646 | 1323.0 | 118.5 | 59.2 | An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. | Jesper L R Andersson, Stamatios N Sotiropoulos | Neuroimage | 2016 | 26481672 | Yes |
| 2930 | 3967 | 1322.3 | 115.7 | 38.6 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
| 2931 | 1322 | 1322.0 | 34.0 | 34.0 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
| 2932 | 1322 | 1322.0 | 30.6 | 30.6 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | No |
| 2933 | 2643 | 1321.5 | 111.3 | 55.6 | Activation of apoptosis signalling pathways by reactive oxygen species. | Maureen Redza-Dutordoir, Diana A Averill-Bates | Biochim Biophys Acta | 2016 | 27646922 | No |
| 2934 | 5285 | 1321.2 | 135.4 | 33.9 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 2935 | 1321 | 1321.0 | 52.6 | 52.6 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2936 | 2642 | 1321.0 | 40.4 | 20.2 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 2937 | 1321 | 1321.0 | 26.9 | 26.9 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | No |
| 2938 | 2640 | 1320.0 | 71.7 | 35.9 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2939 | 1320 | 1320.0 | 61.6 | 61.6 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 2940 | 2640 | 1320.0 | 83.1 | 41.5 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
| 2941 | 3959 | 1319.7 | 104.1 | 34.7 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Gunter Oberdorster, Eva Oberdorster, Jan Oberdorster | Environ Health Perspect | 2005 | 16002369 | No |
| 2942 | 2639 | 1319.5 | 88.1 | 44.0 | Inflammasomes: mechanism of assembly, regulation and signalling. | Petr Broz, Vishva M Dixit | Nat Rev Immunol | 2016 | 27291964 | No |
| 2943 | 2637 | 1318.5 | 68.0 | 34.0 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
| 2944 | 2636 | 1318.0 | 66.1 | 33.0 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
| 2945 | 1318 | 1318.0 | 25.2 | 25.2 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2946 | 3954 | 1318.0 | 91.6 | 30.5 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Goncalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 2947 | 2634 | 1317.0 | 106.9 | 53.5 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2948 | 1317 | 1317.0 | 31.1 | 31.1 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 2949 | 3951 | 1317.0 | 95.4 | 31.8 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 2950 | 3951 | 1317.0 | 110.5 | 36.8 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 2951 | 1316 | 1316.0 | 37.2 | 37.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 2952 | 2632 | 1316.0 | 23.9 | 11.9 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 2953 | 1316 | 1316.0 | 41.9 | 41.9 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | No |
| 2954 | 2631 | 1315.5 | 46.5 | 23.2 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
| 2955 | 3944 | 1314.7 | 105.7 | 35.2 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2956 | 2629 | 1314.5 | 43.6 | 21.8 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 2957 | 6572 | 1314.4 | 181.0 | 36.2 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 2958 | 1314 | 1314.0 | 35.4 | 35.4 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 2959 | 5255 | 1313.8 | 107.4 | 26.9 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
| 2960 | 1313 | 1313.0 | 67.4 | 67.4 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2961 | 1313 | 1313.0 | 17.5 | 17.5 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 2962 | 1313 | 1313.0 | 27.4 | 27.4 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 2963 | 2626 | 1313.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A EDMONDSON, P E STEINER | Cancer | 1954 | 13160935 | Yes |
| 2964 | 2626 | 1313.0 | 54.2 | 27.1 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
| 2965 | 3938 | 1312.7 | 121.4 | 40.5 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 2966 | 3937 | 1312.3 | 173.3 | 57.8 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2967 | 1312 | 1312.0 | 34.4 | 34.4 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
| 2968 | 1312 | 1312.0 | 23.1 | 23.1 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 2969 | 1312 | 1312.0 | 38.1 | 38.1 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
| 2970 | 2624 | 1312.0 | 100.0 | 50.0 | Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. | Ian Janssen, Allana G Leblanc | Int J Behav Nutr Phys Act | 2010 | 20459784 | Yes |
| 2971 | 2623 | 1311.5 | 49.5 | 24.8 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 2972 | 2622 | 1311.0 | 55.1 | 27.6 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
| 2973 | 2622 | 1311.0 | 56.7 | 28.4 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 2974 | 1311 | 1311.0 | 32.4 | 32.4 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 2975 | 2621 | 1310.5 | 61.3 | 30.6 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 2976 | 2621 | 1310.5 | 32.5 | 16.2 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H VANDENDOOL, P D KRATZ | J Chromatogr | 1963 | 14062605 | Yes |
| 2977 | 7861 | 1310.2 | 311.7 | 51.9 | Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. | Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark Wymer | Hepatology | 2016 | 26707365 | No |
| 2978 | 1310 | 1310.0 | 30.9 | 30.9 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 2979 | 1310 | 1310.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F SCHOLANDER | J Biol Chem | 1947 | 20281644 | Yes |
| 2980 | 2619 | 1309.5 | 63.0 | 31.5 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
| 2981 | 2618 | 1309.0 | 59.3 | 29.6 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2982 | 1309 | 1309.0 | 34.6 | 34.6 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 2983 | 1309 | 1309.0 | 39.4 | 39.4 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
| 2984 | 1309 | 1309.0 | 30.7 | 30.7 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
| 2985 | 1309 | 1309.0 | 27.0 | 27.0 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | No |
| 2986 | 2618 | 1309.0 | 110.0 | 55.0 | Principal component analysis: a review and recent developments. | Ian T Jolliffe, Jorge Cadima | Philos Trans A Math Phys Eng Sci | 2016 | 26953178 | No |
| 2987 | 2617 | 1308.5 | 51.0 | 25.5 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
| 2988 | 1308 | 1308.0 | 45.9 | 45.9 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2989 | 3924 | 1308.0 | 132.6 | 44.2 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 2990 | 1308 | 1308.0 | 31.0 | 31.0 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
| 2991 | 1308 | 1308.0 | 30.3 | 30.3 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 2992 | 2615 | 1307.5 | 50.1 | 25.1 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 2993 | 1307 | 1307.0 | 43.3 | 43.3 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 2994 | 1307 | 1307.0 | 28.6 | 28.6 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 2995 | 2614 | 1307.0 | 80.1 | 40.0 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | No |
| 2996 | 2612 | 1306.0 | 77.2 | 38.6 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 2997 | 1306 | 1306.0 | 34.7 | 34.7 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
| 2998 | 2612 | 1306.0 | 44.9 | 22.4 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
| 2999 | 1306 | 1306.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S FARR | J Infect Dis | 1958 | 13611294 | Yes |
| 3000 | 2612 | 1306.0 | 68.7 | 34.4 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3001 | 3917 | 1305.7 | 96.5 | 32.2 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | No |
| 3002 | 1305 | 1305.0 | 28.8 | 28.8 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 3003 | 1305 | 1305.0 | 83.8 | 83.8 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 3004 | 2610 | 1305.0 | 79.0 | 39.5 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 3005 | 2608 | 1304.0 | 138.1 | 69.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R GUILLARD, J H RYTHER | Can J Microbiol | 1962 | 13902807 | Yes |
| 3006 | 1304 | 1304.0 | 34.8 | 34.8 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
| 3007 | 1304 | 1304.0 | 28.8 | 28.8 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | No |
| 3008 | 1304 | 1304.0 | 53.4 | 53.4 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3009 | 2607 | 1303.5 | 73.6 | 36.8 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | No |
| 3010 | 6517 | 1303.4 | 314.5 | 62.9 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 3011 | 1303 | 1303.0 | 32.6 | 32.6 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 3012 | 1303 | 1303.0 | 26.9 | 26.9 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
| 3013 | 1303 | 1303.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L MILLER | Science | 1953 | 13056598 | Yes |
| 3014 | 1303 | 1303.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C BRUTON | Pediatrics | 1952 | 14929630 | Yes |
| 3015 | 1302 | 1302.0 | 46.4 | 46.4 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 3016 | 1302 | 1302.0 | 43.5 | 43.5 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
| 3017 | 1302 | 1302.0 | 28.8 | 28.8 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | No |
| 3018 | 2603 | 1301.5 | 83.6 | 41.8 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
| 3019 | 2603 | 1301.5 | 65.6 | 32.8 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 3020 | 2603 | 1301.5 | 83.3 | 41.6 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 3021 | 2602 | 1301.0 | 95.5 | 47.8 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 3022 | 1301 | 1301.0 | 39.3 | 39.3 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 3023 | 1300 | 1300.0 | 33.6 | 33.6 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
| 3024 | 2600 | 1300.0 | 52.8 | 26.4 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 3025 | 1300 | 1300.0 | 34.2 | 34.2 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | No |
| 3026 | 1300 | 1300.0 | 38.6 | 38.6 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 3027 | 1300 | 1300.0 | 40.8 | 40.8 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | No |
| 3028 | 2599 | 1299.5 | 56.8 | 28.4 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | No |
| 3029 | 9096 | 1299.4 | 256.8 | 36.7 | pROC: an open-source package for R and S+ to analyze and compare ROC curves. | Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus Muller | BMC Bioinformatics | 2011 | 21414208 | Yes |
| 3030 | 2598 | 1299.0 | 62.3 | 31.1 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
| 3031 | 3897 | 1299.0 | 90.7 | 30.2 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 3032 | 1299 | 1299.0 | 26.0 | 26.0 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 3033 | 1299 | 1299.0 | 38.1 | 38.1 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 3034 | 1299 | 1299.0 | 24.4 | 24.4 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
| 3035 | 7792 | 1298.7 | 272.2 | 45.4 | ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. | James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling | J Chem Theory Comput | 2015 | 26574453 | Yes |
| 3036 | 2597 | 1298.5 | 74.4 | 37.2 | Crosstalk of reactive oxygen species and NF-κB signaling. | Michael J Morgan, Zheng-gang Liu | Cell Res | 2011 | 21187859 | No |
| 3037 | 1298 | 1298.0 | 28.7 | 28.7 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
| 3038 | 6486 | 1297.2 | 298.6 | 59.7 | Using the framework method for the analysis of qualitative data in multi-disciplinary health research. | Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood | BMC Med Res Methodol | 2013 | 24047204 | Yes |
| 3039 | 1297 | 1297.0 | 30.9 | 30.9 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
| 3040 | 1297 | 1297.0 | 42.1 | 42.1 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 3041 | 1297 | 1297.0 | 30.9 | 30.9 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 3042 | 2594 | 1297.0 | 66.7 | 33.4 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 3043 | 1297 | 1297.0 | 33.7 | 33.7 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3044 | 1297 | 1297.0 | 44.1 | 44.1 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjostrom | J Intern Med | 2013 | 23163728 | No |
| 3045 | 2592 | 1296.0 | 44.3 | 22.1 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 3046 | 3887 | 1295.7 | 96.0 | 32.0 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | No |
| 3047 | 2591 | 1295.5 | 76.6 | 38.3 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | No |
| 3048 | 2590 | 1295.0 | 99.2 | 49.6 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3049 | 1295 | 1295.0 | 32.1 | 32.1 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 3050 | 2590 | 1295.0 | 47.9 | 23.9 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 3051 | 1295 | 1295.0 | 30.1 | 30.1 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 3052 | 1295 | 1295.0 | 32.6 | 32.6 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
| 3053 | 2590 | 1295.0 | 59.0 | 29.5 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoit D'Autreaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | No |
| 3054 | 1294 | 1294.0 | 44.1 | 44.1 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 3055 | 1294 | 1294.0 | 29.6 | 29.6 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
| 3056 | 1294 | 1294.0 | 32.1 | 32.1 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 3057 | 1294 | 1294.0 | 24.8 | 24.8 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
| 3058 | 3880 | 1293.3 | 88.8 | 29.6 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 3059 | 1293 | 1293.0 | 29.5 | 29.5 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 3060 | 2586 | 1293.0 | 48.3 | 24.1 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
| 3061 | 1293 | 1293.0 | 46.2 | 46.2 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | No |
| 3062 | 2585 | 1292.5 | 65.5 | 32.8 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | No |
| 3063 | 3877 | 1292.3 | 107.2 | 35.7 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | Yes |
| 3064 | 2584 | 1292.0 | 49.4 | 24.7 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 3065 | 1292 | 1292.0 | 42.2 | 42.2 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 3066 | 1292 | 1292.0 | 50.8 | 50.8 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | No |
| 3067 | 1292 | 1292.0 | 27.3 | 27.3 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
| 3068 | 1292 | 1292.0 | 25.0 | 25.0 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
| 3069 | 12913 | 1291.3 | 311.8 | 31.2 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3070 | 2582 | 1291.0 | 75.7 | 37.9 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3071 | 2582 | 1291.0 | 82.4 | 41.2 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3072 | 1291 | 1291.0 | 51.5 | 51.5 | Mediation Analysis: A Practitioner's Guide. | Tyler J VanderWeele | Annu Rev Public Health | 2016 | 26653405 | No |
| 3073 | 3872 | 1290.7 | 107.8 | 35.9 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | No |
| 3074 | 2581 | 1290.5 | 168.2 | 84.1 | The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. | Hussin A Rothan, Siddappa N Byrareddy | J Autoimmun | 2020 | 32113704 | No |
| 3075 | 1290 | 1290.0 | 58.8 | 58.8 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 3076 | 1290 | 1290.0 | 37.9 | 37.9 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3077 | 1289 | 1289.0 | 14.3 | 14.3 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 3078 | 1289 | 1289.0 | 39.4 | 39.4 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
| 3079 | 1289 | 1289.0 | 36.1 | 36.1 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
| 3080 | 2578 | 1289.0 | 51.3 | 25.6 | TM-align: a protein structure alignment algorithm based on the TM-score. | Yang Zhang, Jeffrey Skolnick | Nucleic Acids Res | 2005 | 15849316 | Yes |
| 3081 | 1289 | 1289.0 | 35.0 | 35.0 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | No |
| 3082 | 7730 | 1288.3 | 170.5 | 28.4 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3083 | 2576 | 1288.0 | 89.9 | 45.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
| 3084 | 1288 | 1288.0 | 36.8 | 36.8 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 3085 | 2576 | 1288.0 | 70.7 | 35.4 | Mitochondria: in sickness and in health. | Jodi Nunnari, Anu Suomalainen | Cell | 2012 | 22424226 | No |
| 3086 | 2575 | 1287.5 | 59.4 | 29.7 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | No |
| 3087 | 2575 | 1287.5 | 65.5 | 32.8 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
| 3088 | 2575 | 1287.5 | 54.6 | 27.3 | The Polycomb complex PRC2 and its mark in life. | Raphael Margueron, Danny Reinberg | Nature | 2011 | 21248841 | No |
| 3089 | 2574 | 1287.0 | 60.7 | 30.4 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 3090 | 1287 | 1287.0 | 29.8 | 29.8 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
| 3091 | 3860 | 1286.7 | 175.8 | 58.6 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3092 | 1286 | 1286.0 | 38.8 | 38.8 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 3093 | 11570 | 1285.6 | 279.8 | 31.1 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3094 | 1285 | 1285.0 | 29.5 | 29.5 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
| 3095 | 2570 | 1285.0 | 51.5 | 25.8 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
| 3096 | 1285 | 1285.0 | 51.4 | 51.4 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | No |
| 3097 | 1284 | 1284.0 | 25.3 | 25.3 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 3098 | 1284 | 1284.0 | 31.5 | 31.5 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
| 3099 | 1284 | 1284.0 | 39.3 | 39.3 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | No |
| 3100 | 6419 | 1283.8 | 241.0 | 48.2 | Frailty in elderly people. | Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood | Lancet | 2013 | 23395245 | No |
| 3101 | 2566 | 1283.0 | 13.5 | 6.8 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J TODARO, H GREEN | J Cell Biol | 1963 | 13985244 | Yes |
| 3102 | 1283 | 1283.0 | 34.4 | 34.4 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | No |
| 3103 | 3847 | 1282.3 | 86.6 | 28.9 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3104 | 1282 | 1282.0 | 26.9 | 26.9 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3105 | 2563 | 1281.5 | 66.3 | 33.1 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundstrom, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 3106 | 2563 | 1281.5 | 48.9 | 24.4 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 3107 | 3844 | 1281.3 | 92.1 | 30.7 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3108 | 2562 | 1281.0 | 67.3 | 33.6 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
| 3109 | 1281 | 1281.0 | 30.3 | 30.3 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3110 | 1281 | 1281.0 | 26.9 | 26.9 | Human papillomavirus and cervical cancer. | Eileen M Burd | Clin Microbiol Rev | 2003 | 12525422 | No |
| 3111 | 2561 | 1280.5 | 78.5 | 39.2 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | No |
| 3112 | 2561 | 1280.5 | 57.4 | 28.7 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
| 3113 | 1280 | 1280.0 | 38.9 | 38.9 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
| 3114 | 1280 | 1280.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B VERNEY | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 3115 | 1280 | 1280.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M KALCKAR | J Biol Chem | 1947 | 20285041 | Yes |
| 3116 | 2559 | 1279.5 | 104.3 | 52.1 | Designing hydrogels for controlled drug delivery. | Jianyu Li, David J Mooney | Nat Rev Mater | 2016 | 29657852 | Yes |
| 3117 | 1279 | 1279.0 | 27.6 | 27.6 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
| 3118 | 2558 | 1279.0 | 107.7 | 53.9 | The role of inflammation in depression: from evolutionary imperative to modern treatment target. | Andrew H Miller, Charles L Raison | Nat Rev Immunol | 2016 | 26711676 | No |
| 3119 | 5114 | 1278.5 | 143.8 | 36.0 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 3120 | 10227 | 1278.4 | 442.9 | 55.4 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. | Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda | Nat Commun | 2019 | 30944313 | Yes |
| 3121 | 1278 | 1278.0 | 73.3 | 73.3 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D WINTER | Nature | 1962 | 14007593 | Yes |
| 3122 | 1278 | 1278.0 | 30.8 | 30.8 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 3123 | 2556 | 1278.0 | 53.9 | 26.9 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | No |
| 3124 | 2555 | 1277.5 | 65.1 | 32.5 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3125 | 1277 | 1277.0 | 26.7 | 26.7 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | No |
| 3126 | 3829 | 1276.3 | 112.9 | 37.6 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
| 3127 | 1276 | 1276.0 | 46.0 | 46.0 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 3128 | 1276 | 1276.0 | 26.5 | 26.5 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 3129 | 2552 | 1276.0 | 69.0 | 34.5 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3130 | 1276 | 1276.0 | 40.6 | 40.6 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3131 | 8929 | 1275.6 | 223.1 | 31.9 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
| 3132 | 2551 | 1275.5 | 49.6 | 24.8 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 3133 | 2551 | 1275.5 | 58.4 | 29.2 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | No |
| 3134 | 2550 | 1275.0 | 57.0 | 28.5 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 3135 | 1275 | 1275.0 | 61.1 | 61.1 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
| 3136 | 1275 | 1275.0 | 25.7 | 25.7 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
| 3137 | 1275 | 1275.0 | 25.3 | 25.3 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
| 3138 | 1275 | 1275.0 | 37.8 | 37.8 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 3139 | 2549 | 1274.5 | 50.4 | 25.2 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
| 3140 | 1274 | 1274.0 | 31.5 | 31.5 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
| 3141 | 1274 | 1274.0 | 70.4 | 70.4 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A ROSE | Bull World Health Organ | 1962 | 13974778 | Yes |
| 3142 | 1274 | 1274.0 | 25.1 | 25.1 | Searching for intellectual turning points: progressive knowledge domain visualization. | Chaomei Chen | Proc Natl Acad Sci U S A | 2004 | 14724295 | Yes |
| 3143 | 1274 | 1274.0 | 27.8 | 27.8 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
| 3144 | 2548 | 1274.0 | 69.8 | 34.9 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | No |
| 3145 | 1274 | 1274.0 | 32.2 | 32.2 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | No |
| 3146 | 2547 | 1273.5 | 90.9 | 45.5 | MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. | Martin Steinegger, Johannes Soding | Nat Biotechnol | 2017 | 29035372 | Yes |
| 3147 | 2546 | 1273.0 | 101.7 | 50.9 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Naatanen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3148 | 1273 | 1273.0 | 36.0 | 36.0 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
| 3149 | 3818 | 1272.7 | 114.8 | 38.3 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3150 | 2545 | 1272.5 | 84.6 | 42.3 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3151 | 2544 | 1272.0 | 61.7 | 30.9 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
| 3152 | 1272 | 1272.0 | 32.2 | 32.2 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 3153 | 1272 | 1272.0 | 52.6 | 52.6 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. | Daniel J Drucker | Cell Metab | 2018 | 29617641 | No |
| 3154 | 2543 | 1271.5 | 52.3 | 26.1 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3155 | 2543 | 1271.5 | 52.0 | 26.0 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 3156 | 2542 | 1271.0 | 80.5 | 40.2 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3157 | 1271 | 1271.0 | 30.2 | 30.2 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
| 3158 | 1271 | 1271.0 | 20.9 | 20.9 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 3159 | 3812 | 1270.7 | 236.1 | 78.7 | How to perform a meta-analysis with R: a practical tutorial. | Sara Balduzzi, Gerta Rucker, Guido Schwarzer | Evid Based Ment Health | 2019 | 31563865 | Yes |
| 3160 | 13976 | 1270.5 | 323.4 | 29.4 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
| 3161 | 2540 | 1270.0 | 77.6 | 38.8 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3162 | 1270 | 1270.0 | 30.4 | 30.4 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3163 | 2538 | 1269.0 | 48.3 | 24.1 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3164 | 1269 | 1269.0 | 25.0 | 25.0 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | No |
| 3165 | 1269 | 1269.0 | 38.6 | 38.6 | The inflammatory response in myocardial injury, repair, and remodelling. | Nikolaos G Frangogiannis | Nat Rev Cardiol | 2014 | 24663091 | No |
| 3166 | 1268 | 1268.0 | 48.4 | 48.4 | A simple method for determination of serum catalase activity and revision of reference range. | L Goth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3167 | 1268 | 1268.0 | 33.7 | 33.7 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
| 3168 | 1268 | 1268.0 | 46.3 | 46.3 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
| 3169 | 1268 | 1268.0 | 46.6 | 46.6 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3170 | 1267 | 1267.0 | 22.2 | 22.2 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 3171 | 2533 | 1266.5 | 72.6 | 36.3 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
| 3172 | 2533 | 1266.5 | 65.0 | 32.5 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 3173 | 2533 | 1266.5 | 49.8 | 24.9 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 3174 | 2533 | 1266.5 | 77.4 | 38.7 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | No |
| 3175 | 1266 | 1266.0 | 40.1 | 40.1 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
| 3176 | 5064 | 1266.0 | 116.1 | 29.0 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3177 | 1266 | 1266.0 | 25.7 | 25.7 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
| 3178 | 1266 | 1266.0 | 36.0 | 36.0 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | No |
| 3179 | 2532 | 1266.0 | 91.6 | 45.8 | Tumour heterogeneity and resistance to cancer therapies. | Ibiayi Dagogo-Jack, Alice T Shaw | Nat Rev Clin Oncol | 2018 | 29115304 | No |
| 3180 | 2531 | 1265.5 | 66.9 | 33.5 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 3181 | 1265 | 1265.0 | 22.5 | 22.5 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 3182 | 5059 | 1264.8 | 131.2 | 32.8 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Madler, Ning Li | Science | 2006 | 16456071 | No |
| 3183 | 2529 | 1264.5 | 65.3 | 32.6 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | No |
| 3184 | 1264 | 1264.0 | 34.5 | 34.5 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
| 3185 | 1264 | 1264.0 | 21.4 | 21.4 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 3186 | 1264 | 1264.0 | 24.0 | 24.0 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3187 | 1264 | 1264.0 | 32.1 | 32.1 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3188 | 2527 | 1263.5 | 57.6 | 28.8 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
| 3189 | 1263 | 1263.0 | 29.5 | 29.5 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
| 3190 | 3788 | 1262.7 | 88.2 | 29.4 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | No |
| 3191 | 1262 | 1262.0 | 25.7 | 25.7 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
| 3192 | 1262 | 1262.0 | 20.4 | 20.4 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
| 3193 | 1262 | 1262.0 | 34.8 | 34.8 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
| 3194 | 3785 | 1261.7 | 91.2 | 30.4 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | No |
| 3195 | 1261 | 1261.0 | 36.5 | 36.5 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
| 3196 | 1261 | 1261.0 | 39.0 | 39.0 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
| 3197 | 1261 | 1261.0 | 35.9 | 35.9 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
| 3198 | 2522 | 1261.0 | 57.0 | 28.5 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3199 | 2521 | 1260.5 | 76.7 | 38.4 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 3200 | 1260 | 1260.0 | 27.9 | 27.9 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
| 3201 | 1260 | 1260.0 | 24.5 | 24.5 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 3202 | 5038 | 1259.5 | 260.9 | 65.2 | Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. | Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun | IEEE Trans Pattern Anal Mach Intell | 2017 | 27295650 | Yes |
| 3203 | 1259 | 1259.0 | 26.9 | 26.9 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 3204 | 2518 | 1259.0 | 97.6 | 48.8 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | No |
| 3205 | 1259 | 1259.0 | 26.5 | 26.5 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
| 3206 | 1259 | 1259.0 | 33.2 | 33.2 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | No |
| 3207 | 7551 | 1258.5 | 162.3 | 27.1 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3208 | 1258 | 1258.0 | 25.6 | 25.6 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 3209 | 2516 | 1258.0 | 60.9 | 30.4 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
| 3210 | 1258 | 1258.0 | 32.0 | 32.0 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3211 | 1258 | 1258.0 | 27.4 | 27.4 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | No |
| 3212 | 1257 | 1257.0 | 34.0 | 34.0 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3213 | 1257 | 1257.0 | 35.5 | 35.5 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
| 3214 | 1257 | 1257.0 | 0.0 | 0.0 | A modification of receptor theory. | R P STEPHENSON | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 3215 | 1257 | 1257.0 | 26.3 | 26.3 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 3216 | 3770 | 1256.7 | 105.5 | 35.2 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stephane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3217 | 2513 | 1256.5 | 68.5 | 34.2 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 3218 | 1256 | 1256.0 | 60.6 | 60.6 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3219 | 2512 | 1256.0 | 91.5 | 45.8 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 3220 | 1256 | 1256.0 | 31.3 | 31.3 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
| 3221 | 1256 | 1256.0 | 25.2 | 25.2 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
| 3222 | 1255 | 1255.0 | 30.8 | 30.8 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
| 3223 | 1255 | 1255.0 | 32.4 | 32.4 | Philosophical conceptions of the self: implications for cognitive science. | I Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3224 | 2510 | 1255.0 | 69.6 | 34.8 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3225 | 2509 | 1254.5 | 52.3 | 26.1 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | No |
| 3226 | 1254 | 1254.0 | 42.0 | 42.0 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
| 3227 | 1254 | 1254.0 | 33.2 | 33.2 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
| 3228 | 2507 | 1253.5 | 89.6 | 44.8 | Comparative Protein Structure Modeling Using MODELLER. | Benjamin Webb, Andrej Sali | Curr Protoc Bioinformatics | 2016 | 27322406 | Yes |
| 3229 | 2506 | 1253.0 | 57.6 | 28.8 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 3230 | 1253 | 1253.0 | 26.0 | 26.0 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
| 3231 | 1253 | 1253.0 | 29.2 | 29.2 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
| 3232 | 1253 | 1253.0 | 31.6 | 31.6 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3233 | 1253 | 1253.0 | 33.6 | 33.6 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | No |
| 3234 | 1253 | 1253.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B MEDAWAR | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3235 | 7516 | 1252.7 | 276.0 | 46.0 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3236 | 1252 | 1252.0 | 44.4 | 44.4 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 3237 | 1252 | 1252.0 | 24.5 | 24.5 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 3238 | 1252 | 1252.0 | 28.7 | 28.7 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | No |
| 3239 | 1252 | 1252.0 | 29.6 | 29.6 | Identifying and characterizing binding sites and assessing druggability. | Thomas A Halgren | J Chem Inf Model | 2009 | 19434839 | Yes |
| 3240 | 2502 | 1251.0 | 48.4 | 24.2 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 3241 | 1251 | 1251.0 | 22.8 | 22.8 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 3242 | 1251 | 1251.0 | 46.3 | 46.3 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
| 3243 | 1251 | 1251.0 | 32.4 | 32.4 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
| 3244 | 1251 | 1251.0 | 22.5 | 22.5 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 3245 | 3753 | 1251.0 | 96.2 | 32.1 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | No |
| 3246 | 1251 | 1251.0 | 53.4 | 53.4 | Review of the psychometric evidence of the perceived stress scale. | Eun-Hyun Lee | Asian Nurs Res (Korean Soc Nurs Sci) | 2012 | 25031113 | Yes |
| 3247 | 3752 | 1250.7 | 129.3 | 43.1 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. | Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott | Physiol Rev | 2014 | 24987008 | No |
| 3248 | 2501 | 1250.5 | 95.1 | 47.5 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. | Michael A Gimbrone, Guillermo Garcia-Cardena | Circ Res | 2016 | 26892962 | No |
| 3249 | 1250 | 1250.0 | 39.9 | 39.9 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 3250 | 1249 | 1249.0 | 15.7 | 15.7 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
| 3251 | 1249 | 1249.0 | 28.4 | 28.4 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3252 | 1249 | 1249.0 | 62.6 | 62.6 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3253 | 2498 | 1249.0 | 62.7 | 31.4 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 3254 | 1249 | 1249.0 | 53.9 | 53.9 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3255 | 1249 | 1249.0 | 33.7 | 33.7 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | No |
| 3256 | 2497 | 1248.5 | 67.9 | 34.0 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3257 | 2496 | 1248.0 | 66.0 | 33.0 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 3258 | 1248 | 1248.0 | 46.5 | 46.5 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 3259 | 1248 | 1248.0 | 24.6 | 24.6 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
| 3260 | 2496 | 1248.0 | 64.1 | 32.0 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3261 | 2496 | 1248.0 | 48.0 | 24.0 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 3262 | 1248 | 1248.0 | 37.0 | 37.0 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
| 3263 | 1248 | 1248.0 | 30.1 | 30.1 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
| 3264 | 1248 | 1248.0 | 30.6 | 30.6 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | No |
| 3265 | 1248 | 1248.0 | 35.3 | 35.3 | pegas: an R package for population genetics with an integrated-modular approach. | Emmanuel Paradis | Bioinformatics | 2010 | 20080509 | Yes |
| 3266 | 1248 | 1248.0 | 30.6 | 30.6 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3267 | 8736 | 1248.0 | 558.0 | 79.7 | IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. | Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert Lanfear | Mol Biol Evol | 2020 | 32011700 | Yes |
| 3268 | 2495 | 1247.5 | 52.4 | 26.2 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
| 3269 | 8726 | 1246.6 | 264.3 | 37.8 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3270 | 2492 | 1246.0 | 118.4 | 59.2 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 3271 | 1246 | 1246.0 | 45.0 | 45.0 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
| 3272 | 1246 | 1246.0 | 27.3 | 27.3 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
| 3273 | 6230 | 1246.0 | 166.7 | 33.3 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3274 | 1246 | 1246.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E MORTON | Am J Hum Genet | 1955 | 13258560 | Yes |
| 3275 | 1246 | 1246.0 | 22.4 | 22.4 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
| 3276 | 1246 | 1246.0 | 23.5 | 23.5 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
| 3277 | 1246 | 1246.0 | 30.2 | 30.2 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
| 3278 | 1246 | 1246.0 | 25.3 | 25.3 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | No |
| 3279 | 1246 | 1246.0 | 33.2 | 33.2 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | No |
| 3280 | 3736 | 1245.3 | 97.0 | 32.3 | FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | Mol Biol Evol | 2009 | 19377059 | Yes |
| 3281 | 6223 | 1244.6 | 113.0 | 22.6 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 3282 | 2488 | 1244.0 | 60.9 | 30.4 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
| 3283 | 2488 | 1244.0 | 72.3 | 36.1 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3284 | 1244 | 1244.0 | 24.4 | 24.4 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3285 | 1244 | 1244.0 | 35.0 | 35.0 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3286 | 3731 | 1243.7 | 124.0 | 41.3 | Ecological momentary assessment. | Saul Shiffman, Arthur A Stone, Michael R Hufford | Annu Rev Clin Psychol | 2008 | 18509902 | No |
| 3287 | 3730 | 1243.3 | 144.1 | 48.0 | Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. | Antonio Ayala, Mario F Munoz, Sandro Arguelles | Oxid Med Cell Longev | 2014 | 24999379 | No |
| 3288 | 1243 | 1243.0 | 41.9 | 41.9 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
| 3289 | 1242 | 1242.0 | 24.8 | 24.8 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3290 | 1242 | 1242.0 | 21.3 | 21.3 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat Rev Immunol | 2005 | 15928679 | No |
| 3291 | 1242 | 1242.0 | 39.2 | 39.2 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | No |
| 3292 | 2482 | 1241.0 | 91.4 | 45.7 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3293 | 1241 | 1241.0 | 26.6 | 26.6 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3294 | 1241 | 1241.0 | 15.4 | 15.4 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M VAN ROSSUM | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 3295 | 6203 | 1240.6 | 191.4 | 38.3 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 3296 | 2481 | 1240.5 | 67.6 | 33.8 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3297 | 2481 | 1240.5 | 66.4 | 33.2 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. | Marie Cargnello, Philippe P Roux | Microbiol Mol Biol Rev | 2011 | 21372320 | No |
| 3298 | 9923 | 1240.4 | 301.7 | 37.7 | Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. | V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks | Am J Prev Med | 1998 | 9635069 | Yes |
| 3299 | 1240 | 1240.0 | 37.0 | 37.0 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
| 3300 | 2480 | 1240.0 | 88.2 | 44.1 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3301 | 1240 | 1240.0 | 36.0 | 36.0 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3302 | 1240 | 1240.0 | 23.1 | 23.1 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 3303 | 7439 | 1239.8 | 134.9 | 22.5 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3304 | 1239 | 1239.0 | 55.4 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 3305 | 6195 | 1239.0 | 205.2 | 41.0 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3306 | 2478 | 1239.0 | 53.2 | 26.6 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N AMES, D T DUBIN | J Biol Chem | 1960 | 13793161 | Yes |
| 3307 | 1239 | 1239.0 | 47.5 | 47.5 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | No |
| 3308 | 1238 | 1238.0 | 36.5 | 36.5 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 3309 | 1238 | 1238.0 | 37.6 | 37.6 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 3310 | 1238 | 1238.0 | 41.6 | 41.6 | Human milk oligosaccharides: every baby needs a sugar mama. | Lars Bode | Glycobiology | 2012 | 22513036 | No |
| 3311 | 3713 | 1237.7 | 73.8 | 24.6 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
| 3312 | 7426 | 1237.7 | 163.8 | 27.3 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3313 | 2475 | 1237.5 | 57.4 | 28.7 | Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. | In Suk Joung, Thomas E Cheatham | J Phys Chem B | 2008 | 18593145 | Yes |
| 3314 | 1237 | 1237.0 | 57.3 | 57.3 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3315 | 2474 | 1237.0 | 84.1 | 42.0 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | No |
| 3316 | 1237 | 1237.0 | 26.8 | 26.8 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 3317 | 1237 | 1237.0 | 29.2 | 29.2 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | No |
| 3318 | 2474 | 1237.0 | 68.0 | 34.0 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | No |
| 3319 | 1237 | 1237.0 | 43.0 | 43.0 | Type 2 inflammation in asthma--present in most, absent in many. | John V Fahy | Nat Rev Immunol | 2015 | 25534623 | No |
| 3320 | 1236 | 1236.0 | 20.9 | 20.9 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 3321 | 2471 | 1235.5 | 39.3 | 19.6 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 3322 | 2471 | 1235.5 | 49.9 | 24.9 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 3323 | 1235 | 1235.0 | 58.6 | 58.6 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3324 | 1235 | 1235.0 | 25.2 | 25.2 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
| 3325 | 3705 | 1235.0 | 75.1 | 25.0 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | No |
| 3326 | 2469 | 1234.5 | 82.2 | 41.1 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | No |
| 3327 | 1234 | 1234.0 | 27.3 | 27.3 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
| 3328 | 3701 | 1233.7 | 92.5 | 30.8 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3329 | 2467 | 1233.5 | 69.0 | 34.5 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
| 3330 | 2466 | 1233.0 | 51.8 | 25.9 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
| 3331 | 3697 | 1232.3 | 70.9 | 23.6 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | No |
| 3332 | 1232 | 1232.0 | 31.3 | 31.3 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
| 3333 | 2464 | 1232.0 | 54.9 | 27.4 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | No |
| 3334 | 2463 | 1231.5 | 63.2 | 31.6 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 3335 | 1231 | 1231.0 | 25.7 | 25.7 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
| 3336 | 1231 | 1231.0 | 28.9 | 28.9 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3337 | 1231 | 1231.0 | 32.3 | 32.3 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3338 | 1231 | 1231.0 | 23.8 | 23.8 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
| 3339 | 1231 | 1231.0 | 35.1 | 35.1 | The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. | John Duncan | Trends Cogn Sci | 2010 | 20171926 | No |
| 3340 | 2462 | 1231.0 | 80.5 | 40.2 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | No |
| 3341 | 2461 | 1230.5 | 48.8 | 24.4 | The mammalian unfolded protein response. | Martin Schroder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
| 3342 | 13532 | 1230.2 | 248.4 | 22.6 | Model-based analysis of ChIP-Seq (MACS). | Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu | Genome Biol | 2008 | 18798982 | Yes |
| 3343 | 1230 | 1230.0 | 33.9 | 33.9 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 3344 | 3690 | 1230.0 | 103.3 | 34.4 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3345 | 1230 | 1230.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G BUONOCORE | J Dent Res | 1955 | 13271655 | Yes |
| 3346 | 1230 | 1230.0 | 31.6 | 31.6 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3347 | 2459 | 1229.5 | 75.7 | 37.9 | Infernal 1.1: 100-fold faster RNA homology searches. | Eric P Nawrocki, Sean R Eddy | Bioinformatics | 2013 | 24008419 | Yes |
| 3348 | 1229 | 1229.0 | 31.2 | 31.2 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 3349 | 2458 | 1229.0 | 64.3 | 32.1 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | No |
| 3350 | 1228 | 1228.0 | 28.4 | 28.4 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
| 3351 | 1228 | 1228.0 | 25.0 | 25.0 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 3352 | 2454 | 1227.0 | 53.6 | 26.8 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 3353 | 1227 | 1227.0 | 30.4 | 30.4 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsaki | Neuroscience | 1989 | 2687720 | No |
| 3354 | 1227 | 1227.0 | 30.5 | 30.5 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
| 3355 | 1227 | 1227.0 | 33.5 | 33.5 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
| 3356 | 1227 | 1227.0 | 23.6 | 23.6 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
| 3357 | 1227 | 1227.0 | 26.0 | 26.0 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3358 | 2453 | 1226.5 | 57.8 | 28.9 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3359 | 12264 | 1226.4 | 392.3 | 39.2 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3360 | 3677 | 1225.7 | 111.1 | 37.0 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 3361 | 1225 | 1225.0 | 58.3 | 58.3 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 3362 | 1225 | 1225.0 | 22.1 | 22.1 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 3363 | 1225 | 1225.0 | 25.1 | 25.1 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
| 3364 | 2450 | 1225.0 | 72.4 | 36.2 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3365 | 2448 | 1224.0 | 54.1 | 27.1 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3366 | 1224 | 1224.0 | 108.8 | 108.8 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3367 | 1224 | 1224.0 | 32.6 | 32.6 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
| 3368 | 1224 | 1224.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A MERTON | J Physiol | 1954 | 13152698 | Yes |
| 3369 | 1224 | 1224.0 | 41.5 | 41.5 | Considerations in determining sample size for pilot studies. | Melody A Hertzog | Res Nurs Health | 2008 | 18183564 | No |
| 3370 | 2448 | 1224.0 | 69.5 | 34.8 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | No |
| 3371 | 1223 | 1223.0 | 25.7 | 25.7 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 3372 | 1223 | 1223.0 | 33.4 | 33.4 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | No |
| 3373 | 2446 | 1223.0 | 99.6 | 49.8 | Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. | Douglas J Morrison, Tom Preston | Gut Microbes | 2016 | 26963409 | No |
| 3374 | 3668 | 1222.7 | 101.9 | 34.0 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3375 | 3668 | 1222.7 | 60.1 | 20.0 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, Rene Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3376 | 2444 | 1222.0 | 71.6 | 35.8 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 3377 | 1222 | 1222.0 | 28.3 | 28.3 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3378 | 4887 | 1221.8 | 139.4 | 34.9 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3379 | 2443 | 1221.5 | 82.3 | 41.1 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
| 3380 | 1221 | 1221.0 | 23.7 | 23.7 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
| 3381 | 1221 | 1221.0 | 24.4 | 24.4 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
| 3382 | 1221 | 1221.0 | 22.5 | 22.5 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
| 3383 | 2442 | 1221.0 | 61.2 | 30.6 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | No |
| 3384 | 2442 | 1221.0 | 188.9 | 94.5 | Mental Health and the Covid-19 Pandemic. | Betty Pfefferbaum, Carol S North | N Engl J Med | 2020 | 32283003 | Yes |
| 3385 | 3662 | 1220.7 | 93.0 | 31.0 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3386 | 2441 | 1220.5 | 76.4 | 38.2 | Toll-like receptor signaling pathways. | Takumi Kawasaki, Taro Kawai | Front Immunol | 2014 | 25309543 | No |
| 3387 | 1220 | 1220.0 | 40.6 | 40.6 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
| 3388 | 1220 | 1220.0 | 74.0 | 74.0 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3389 | 1220 | 1220.0 | 28.0 | 28.0 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3390 | 2440 | 1220.0 | 88.0 | 44.0 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3391 | 2440 | 1220.0 | 57.6 | 28.8 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | No |
| 3392 | 3657 | 1219.0 | 126.8 | 42.3 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3393 | 3656 | 1218.7 | 72.1 | 24.0 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3394 | 2437 | 1218.5 | 26.1 | 13.1 | The Aggregation Of Blood Platelets. | G V BORN, M J CROSS | J Physiol | 1963 | 14056485 | Yes |
| 3395 | 2437 | 1218.5 | 52.3 | 26.1 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | No |
| 3396 | 1218 | 1218.0 | 31.0 | 31.0 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | No |
| 3397 | 2435 | 1217.5 | 62.1 | 31.1 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3398 | 2435 | 1217.5 | 68.4 | 34.2 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3399 | 3651 | 1217.0 | 81.9 | 27.3 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernan, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3400 | 2434 | 1217.0 | 91.0 | 45.5 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jerome Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | No |
| 3401 | 2433 | 1216.5 | 50.7 | 25.4 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3402 | 1216 | 1216.0 | 29.0 | 29.0 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
| 3403 | 2432 | 1216.0 | 123.9 | 62.0 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3404 | 1216 | 1216.0 | 63.4 | 63.4 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3405 | 1216 | 1216.0 | 75.7 | 75.7 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3406 | 1216 | 1216.0 | 22.5 | 22.5 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
| 3407 | 1216 | 1216.0 | 31.7 | 31.7 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | Yes |
| 3408 | 2431 | 1215.5 | 104.8 | 52.4 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3409 | 3646 | 1215.3 | 80.4 | 26.8 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3410 | 1215 | 1215.0 | 48.3 | 48.3 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
| 3411 | 1215 | 1215.0 | 29.0 | 29.0 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 3412 | 1215 | 1215.0 | 53.4 | 53.4 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3413 | 4859 | 1214.8 | 90.5 | 22.6 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3414 | 2429 | 1214.5 | 103.3 | 51.6 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. | Luigi Ferrucci, Elisa Fabbri | Nat Rev Cardiol | 2018 | 30065258 | No |
| 3415 | 1214 | 1214.0 | 32.7 | 32.7 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
| 3416 | 1214 | 1214.0 | 30.2 | 30.2 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 3417 | 1214 | 1214.0 | 29.7 | 29.7 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3418 | 1214 | 1214.0 | 33.5 | 33.5 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. | Masabumi Shibuya | Genes Cancer | 2011 | 22866201 | Yes |
| 3419 | 2427 | 1213.5 | 34.9 | 17.4 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3420 | 2427 | 1213.5 | 45.9 | 22.9 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
| 3421 | 1213 | 1213.0 | 26.3 | 26.3 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 3422 | 2426 | 1213.0 | 42.5 | 21.2 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
| 3423 | 1213 | 1213.0 | 29.7 | 29.7 | Seed Germination and Dormancy. | J. D. Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3424 | 1213 | 1213.0 | 54.4 | 54.4 | A decade of immune-checkpoint inhibitors in cancer therapy. | Caroline Robert | Nat Commun | 2020 | 32732879 | Yes |
| 3425 | 2425 | 1212.5 | 64.1 | 32.0 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 3426 | 1212 | 1212.0 | 35.9 | 35.9 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
| 3427 | 1212 | 1212.0 | 26.7 | 26.7 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 3428 | 1212 | 1212.0 | 28.7 | 28.7 | Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" | F D Haldane | Phys Rev Lett | 1988 | 10038961 | Yes |
| 3429 | 1212 | 1212.0 | 29.8 | 29.8 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 3430 | 1212 | 1212.0 | 25.3 | 25.3 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 3431 | 6059 | 1211.8 | 211.9 | 42.4 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3432 | 1211 | 1211.0 | 27.9 | 27.9 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
| 3433 | 1211 | 1211.0 | 44.8 | 44.8 | The angular gyrus: multiple functions and multiple subdivisions. | Mohamed L Seghier | Neuroscientist | 2013 | 22547530 | No |
| 3434 | 1210 | 1210.0 | 52.1 | 52.1 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3435 | 1210 | 1210.0 | 33.0 | 33.0 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
| 3436 | 1210 | 1210.0 | 50.2 | 50.2 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3437 | 1210 | 1210.0 | 42.1 | 42.1 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3438 | 2420 | 1210.0 | 52.0 | 26.0 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3439 | 1210 | 1210.0 | 30.5 | 30.5 | The quantum internet. | H J Kimble | Nature | 2008 | 18563153 | Yes |
| 3440 | 2418 | 1209.0 | 68.1 | 34.0 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | No |
| 3441 | 2418 | 1209.0 | 95.1 | 47.5 | Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. | T J Cole, T Lobstein | Pediatr Obes | 2012 | 22715120 | Yes |
| 3442 | 3627 | 1209.0 | 119.0 | 39.7 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | No |
| 3443 | 1209 | 1209.0 | 40.2 | 40.2 | DREADDs for Neuroscientists. | Bryan L Roth | Neuron | 2016 | 26889809 | No |
| 3444 | 2417 | 1208.5 | 97.4 | 48.7 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3445 | 7251 | 1208.5 | 171.6 | 28.6 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, | Lancet | 2002 | 12493255 | Yes |
| 3446 | 1208 | 1208.0 | 17.4 | 17.4 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E HOPE-SIMPSON | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3447 | 1208 | 1208.0 | 32.2 | 32.2 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3448 | 1208 | 1208.0 | 22.9 | 22.9 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | No |
| 3449 | 3624 | 1208.0 | 177.4 | 59.1 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | No |
| 3450 | 2415 | 1207.5 | 68.7 | 34.4 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3451 | 1207 | 1207.0 | 63.2 | 63.2 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3452 | 1207 | 1207.0 | 37.8 | 37.8 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
| 3453 | 1207 | 1207.0 | 26.6 | 26.6 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
| 3454 | 1207 | 1207.0 | 38.0 | 38.0 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3455 | 1207 | 1207.0 | 38.4 | 38.4 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
| 3456 | 1207 | 1207.0 | 58.8 | 58.8 | Osseointegration and its experimental background. | P I Branemark | J Prosthet Dent | 1983 | 6352924 | No |
| 3457 | 3621 | 1207.0 | 167.3 | 55.8 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3458 | 2414 | 1207.0 | 58.9 | 29.4 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3459 | 1207 | 1207.0 | 25.4 | 25.4 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3460 | 2413 | 1206.5 | 52.8 | 26.4 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3461 | 2413 | 1206.5 | 44.2 | 22.1 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
| 3462 | 1206 | 1206.0 | 41.2 | 41.2 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3463 | 1206 | 1206.0 | 33.6 | 33.6 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3464 | 2412 | 1206.0 | 43.5 | 21.8 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3465 | 2412 | 1206.0 | 52.7 | 26.4 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | Yes |
| 3466 | 1206 | 1206.0 | 29.2 | 29.2 | Overview of the immune response. | David D Chaplin | J Allergy Clin Immunol | 2010 | 20176265 | No |
| 3467 | 3618 | 1206.0 | 121.1 | 40.4 | Social relationships and mortality risk: a meta-analytic review. | Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton | PLoS Med | 2010 | 20668659 | No |
| 3468 | 2410 | 1205.0 | 87.7 | 43.9 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3469 | 1205 | 1205.0 | 18.5 | 18.5 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3470 | 3615 | 1205.0 | 180.1 | 60.0 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3471 | 1205 | 1205.0 | 20.4 | 20.4 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
| 3472 | 1205 | 1205.0 | 19.1 | 19.1 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
| 3473 | 2410 | 1205.0 | 56.7 | 28.4 | Interaction revisited: the difference between two estimates. | Douglas G Altman, J Martin Bland | BMJ | 2003 | 12543843 | No |
| 3474 | 1205 | 1205.0 | 37.4 | 37.4 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan St B T Evans | Annu Rev Psychol | 2008 | 18154502 | No |
| 3475 | 4820 | 1205.0 | 123.7 | 30.9 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3476 | 1205 | 1205.0 | 43.1 | 43.1 | Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. | Georgia Salanti | Res Synth Methods | 2012 | 26062083 | Yes |
| 3477 | 1205 | 1205.0 | 58.7 | 58.7 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. | Hector F Escobar-Morreale | Nat Rev Endocrinol | 2018 | 29569621 | No |
| 3478 | 3613 | 1204.3 | 91.6 | 30.5 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3479 | 1204 | 1204.0 | 49.0 | 49.0 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
| 3480 | 1204 | 1204.0 | 32.7 | 32.7 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
| 3481 | 1204 | 1204.0 | 33.3 | 33.3 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | No |
| 3482 | 7222 | 1203.7 | 243.9 | 40.6 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3483 | 2407 | 1203.5 | 105.0 | 52.5 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3484 | 3610 | 1203.3 | 110.0 | 36.7 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3485 | 1203 | 1203.0 | 21.3 | 21.3 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3486 | 1203 | 1203.0 | 10.0 | 10.0 | A New Serum Type System In Man--The Lp System. | K BERG | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3487 | 1203 | 1203.0 | 33.6 | 33.6 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | No |
| 3488 | 2406 | 1203.0 | 69.3 | 34.6 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | No |
| 3489 | 2405 | 1202.5 | 48.2 | 24.1 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3490 | 2405 | 1202.5 | 56.6 | 28.3 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | No |
| 3491 | 6011 | 1202.2 | 140.9 | 28.2 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3492 | 1202 | 1202.0 | 29.7 | 29.7 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3493 | 1202 | 1202.0 | 28.5 | 28.5 | Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. | R Zahorec | Bratisl Lek Listy | 2001 | 11723675 | Yes |
| 3494 | 1202 | 1202.0 | 39.7 | 39.7 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3495 | 12016 | 1201.6 | 263.6 | 26.4 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3496 | 2403 | 1201.5 | 90.0 | 45.0 | The Human Intestinal Microbiome in Health and Disease. | Susan V Lynch, Oluf Pedersen | N Engl J Med | 2016 | 27974040 | No |
| 3497 | 1201 | 1201.0 | 36.6 | 36.6 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
| 3498 | 2402 | 1201.0 | 75.5 | 37.8 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3499 | 2402 | 1201.0 | 92.2 | 46.1 | Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. | N L Glass, G C Donaldson | Appl Environ Microbiol | 1995 | 7747954 | Yes |
| 3500 | 1201 | 1201.0 | 32.8 | 32.8 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3501 | 2402 | 1201.0 | 48.0 | 24.0 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 3502 | 2402 | 1201.0 | 77.8 | 38.9 | The gut microbiota--masters of host development and physiology. | Felix Sommer, Fredrik Backhed | Nat Rev Microbiol | 2013 | 23435359 | No |
| 3503 | 3601 | 1200.3 | 85.6 | 28.5 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 3504 | 2400 | 1200.0 | 48.2 | 24.1 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 3505 | 1200 | 1200.0 | 35.2 | 35.2 | The mental health continuum: from languishing to flourishing in life. | Corey L M Keyes | J Health Soc Behav | 2002 | 12096700 | Yes |
| 3506 | 2400 | 1200.0 | 49.6 | 24.8 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
| 3507 | 1200 | 1200.0 | 25.1 | 25.1 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
| 3508 | 1200 | 1200.0 | 34.7 | 34.7 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | No |
| 3509 | 2400 | 1200.0 | 87.6 | 43.8 | OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. | David M Emms, Steven Kelly | Genome Biol | 2015 | 26243257 | Yes |
| 3510 | 4798 | 1199.5 | 114.5 | 28.6 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3511 | 2399 | 1199.5 | 56.0 | 28.0 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | No |
| 3512 | 2399 | 1199.5 | 81.6 | 40.8 | ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. | Tauno Metsalu, Jaak Vilo | Nucleic Acids Res | 2015 | 25969447 | Yes |
| 3513 | 1199 | 1199.0 | 31.9 | 31.9 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | No |
| 3514 | 1199 | 1199.0 | 44.5 | 44.5 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | No |
| 3515 | 10789 | 1198.8 | 352.1 | 39.1 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3516 | 2397 | 1198.5 | 46.4 | 23.2 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3517 | 2397 | 1198.5 | 48.8 | 24.4 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 3518 | 3595 | 1198.3 | 71.6 | 23.9 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
| 3519 | 8387 | 1198.1 | 160.0 | 22.9 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3520 | 1198 | 1198.0 | 45.1 | 45.1 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
| 3521 | 1198 | 1198.0 | 36.5 | 36.5 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
| 3522 | 1198 | 1198.0 | 39.4 | 39.4 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
| 3523 | 1198 | 1198.0 | 30.7 | 30.7 | Inflammation 2010: new adventures of an old flame. | Ruslan Medzhitov | Cell | 2010 | 20303867 | No |
| 3524 | 4791 | 1197.8 | 106.7 | 26.7 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3525 | 7187 | 1197.8 | 150.2 | 25.0 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3526 | 4789 | 1197.2 | 121.7 | 30.4 | Mussel-inspired surface chemistry for multifunctional coatings. | Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith | Science | 2007 | 17947576 | Yes |
| 3527 | 1197 | 1197.0 | 39.9 | 39.9 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3528 | 1197 | 1197.0 | 28.3 | 28.3 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3529 | 1197 | 1197.0 | 44.4 | 44.4 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3530 | 2394 | 1197.0 | 51.9 | 25.9 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
| 3531 | 1197 | 1197.0 | 20.9 | 20.9 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3532 | 1197 | 1197.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C CHANG | Nature | 1951 | 14882325 | Yes |
| 3533 | 5984 | 1196.8 | 233.2 | 46.6 | KEGG: new perspectives on genomes, pathways, diseases and drugs. | Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima | Nucleic Acids Res | 2017 | 27899662 | Yes |
| 3534 | 2393 | 1196.5 | 75.1 | 37.5 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
| 3535 | 2393 | 1196.5 | 63.6 | 31.8 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | No |
| 3536 | 1196 | 1196.0 | 32.2 | 32.2 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
| 3537 | 1196 | 1196.0 | 27.4 | 27.4 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
| 3538 | 1196 | 1196.0 | 27.2 | 27.2 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3539 | 1196 | 1196.0 | 30.8 | 30.8 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
| 3540 | 1196 | 1196.0 | 31.0 | 31.0 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | No |
| 3541 | 1195 | 1195.0 | 44.1 | 44.1 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3542 | 2390 | 1195.0 | 50.6 | 25.3 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
| 3543 | 1195 | 1195.0 | 38.1 | 38.1 | Epidemiology of heart failure. | Veronique L Roger | Circ Res | 2013 | 23989710 | No |
| 3544 | 3583 | 1194.3 | 75.3 | 25.1 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3545 | 1194 | 1194.0 | 56.5 | 56.5 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | No |
| 3546 | 1194 | 1194.0 | 33.6 | 33.6 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 3547 | 2388 | 1194.0 | 52.3 | 26.1 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3548 | 1194 | 1194.0 | 27.3 | 27.3 | Matrix eQTL: ultra fast eQTL analysis via large matrix operations. | Andrey A Shabalin | Bioinformatics | 2012 | 22492648 | Yes |
| 3549 | 1194 | 1194.0 | 45.9 | 45.9 | Vitamin D metabolism, mechanism of action, and clinical applications. | Daniel D Bikle | Chem Biol | 2014 | 24529992 | No |
| 3550 | 2386 | 1193.0 | 37.5 | 18.8 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3551 | 1193 | 1193.0 | 11.5 | 11.5 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3552 | 1193 | 1193.0 | 32.4 | 32.4 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | No |
| 3553 | 2386 | 1193.0 | 85.8 | 42.9 | Gut microbiota, metabolites and host immunity. | Michelle G Rooks, Wendy S Garrett | Nat Rev Immunol | 2016 | 27231050 | No |
| 3554 | 3578 | 1192.7 | 93.6 | 31.2 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3555 | 2385 | 1192.5 | 95.6 | 47.8 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3556 | 2385 | 1192.5 | 73.2 | 36.6 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | No |
| 3557 | 2385 | 1192.5 | 123.2 | 61.6 | Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. | Amy J H Kind, William R Buckingham | N Engl J Med | 2018 | 29949490 | Yes |
| 3558 | 1192 | 1192.0 | 34.0 | 34.0 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
| 3559 | 1192 | 1192.0 | 33.0 | 33.0 | Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. | J C Morris | Int Psychogeriatr | 1997 | 9447441 | Yes |
| 3560 | 1192 | 1192.0 | 22.1 | 22.1 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
| 3561 | 1192 | 1192.0 | 23.5 | 23.5 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G DUNCOMBE | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3562 | 2384 | 1192.0 | 50.0 | 25.0 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
| 3563 | 1192 | 1192.0 | 30.3 | 30.3 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | No |
| 3564 | 1192 | 1192.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3565 | 3576 | 1192.0 | 174.0 | 58.0 | Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. | Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas | Nurs Health Sci | 2013 | 23480423 | No |
| 3566 | 2383 | 1191.5 | 201.9 | 101.0 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3567 | 2383 | 1191.5 | 39.9 | 19.9 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3568 | 1191 | 1191.0 | 68.3 | 68.3 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
| 3569 | 1191 | 1191.0 | 30.9 | 30.9 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 3570 | 1191 | 1191.0 | 22.0 | 22.0 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
| 3571 | 1191 | 1191.0 | 23.0 | 23.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B ASHWORTH | Practitioner | 1964 | 14143329 | Yes |
| 3572 | 2382 | 1191.0 | 64.4 | 32.2 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | No |
| 3573 | 1191 | 1191.0 | 26.5 | 26.5 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
| 3574 | 1191 | 1191.0 | 40.2 | 40.2 | The pain self-efficacy questionnaire: Taking pain into account. | Michael K Nicholas | Eur J Pain | 2007 | 16446108 | Yes |
| 3575 | 1191 | 1191.0 | 35.2 | 35.2 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | No |
| 3576 | 1191 | 1191.0 | 27.0 | 27.0 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | No |
| 3577 | 2381 | 1190.5 | 63.9 | 31.9 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3578 | 3569 | 1189.7 | 106.8 | 35.6 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. | Irith Wiegand, Kai Hilpert, Robert E W Hancock | Nat Protoc | 2008 | 18274517 | Yes |
| 3579 | 3568 | 1189.3 | 134.9 | 45.0 | The biology and management of non-small cell lung cancer. | Roy S Herbst, Daniel Morgensztern, Chris Boshoff | Nature | 2018 | 29364287 | No |
| 3580 | 1189 | 1189.0 | 28.8 | 28.8 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | No |
| 3581 | 1189 | 1189.0 | 23.3 | 23.3 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
| 3582 | 1189 | 1189.0 | 24.3 | 24.3 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | No |
| 3583 | 4754 | 1188.5 | 109.0 | 27.2 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3584 | 2377 | 1188.5 | 96.8 | 48.4 | The Tumor Microenvironment Innately Modulates Cancer Progression. | Dominique C Hinshaw, Lalita A Shevde | Cancer Res | 2019 | 31350295 | No |
| 3585 | 16634 | 1188.1 | 349.6 | 25.0 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3586 | 2376 | 1188.0 | 94.6 | 47.3 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3587 | 1188 | 1188.0 | 24.6 | 24.6 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3588 | 1188 | 1188.0 | 55.2 | 55.2 | The expanding regulatory mechanisms and cellular functions of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2020 | 32366901 | No |
| 3589 | 2375 | 1187.5 | 49.5 | 24.8 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
| 3590 | 5937 | 1187.4 | 190.8 | 38.2 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
| 3591 | 3561 | 1187.0 | 96.6 | 32.2 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3592 | 1187 | 1187.0 | 37.0 | 37.0 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3593 | 1187 | 1187.0 | 29.2 | 29.2 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | No |
| 3594 | 1187 | 1187.0 | 34.6 | 34.6 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3595 | 1187 | 1187.0 | 32.4 | 32.4 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | No |
| 3596 | 2373 | 1186.5 | 57.9 | 28.9 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | No |
| 3597 | 2372 | 1186.0 | 110.7 | 55.4 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3598 | 1186 | 1186.0 | 39.1 | 39.1 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
| 3599 | 1186 | 1186.0 | 34.3 | 34.3 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
| 3600 | 1186 | 1186.0 | 29.2 | 29.2 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | No |
| 3601 | 1186 | 1186.0 | 26.1 | 26.1 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | No |
| 3602 | 1186 | 1186.0 | 28.3 | 28.3 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | No |
| 3603 | 2372 | 1186.0 | 51.2 | 25.6 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3604 | 1186 | 1186.0 | 41.3 | 41.3 | Autonomic nervous system activity in emotion: a review. | Sylvia D Kreibig | Biol Psychol | 2010 | 20371374 | No |
| 3605 | 3557 | 1185.7 | 75.6 | 25.2 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 3606 | 8297 | 1185.3 | 553.6 | 79.1 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. | Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia | Mol Plant | 2020 | 32585190 | Yes |
| 3607 | 1185 | 1185.0 | 38.8 | 38.8 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
| 3608 | 1185 | 1185.0 | 30.7 | 30.7 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3609 | 1185 | 1185.0 | 0.0 | 0.0 | The powerful placebo. | H K BEECHER | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3610 | 1185 | 1185.0 | 33.6 | 33.6 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3611 | 1185 | 1185.0 | 30.2 | 30.2 | Neural stimulation and recording electrodes. | Stuart F Cogan | Annu Rev Biomed Eng | 2008 | 18429704 | No |
| 3612 | 1185 | 1185.0 | 25.7 | 25.7 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | No |
| 3613 | 2369 | 1184.5 | 56.4 | 28.2 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
| 3614 | 3553 | 1184.3 | 90.2 | 30.1 | Fluorine in pharmaceuticals: looking beyond intuition. | Klaus Muller, Christoph Faeh, Francois Diederich | Science | 2007 | 17901324 | No |
| 3615 | 1184 | 1184.0 | 26.0 | 26.0 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3616 | 2368 | 1184.0 | 61.2 | 30.6 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. | Maria M Mihaylova, Reuben J Shaw | Nat Cell Biol | 2011 | 21892142 | No |
| 3617 | 1184 | 1184.0 | 43.5 | 43.5 | A polarizing question: do M1 and M2 microglia exist? | Richard M Ransohoff | Nat Neurosci | 2016 | 27459405 | No |
| 3618 | 3551 | 1183.7 | 70.7 | 23.6 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3619 | 3551 | 1183.7 | 100.0 | 33.3 | Macrophage biology in development, homeostasis and disease. | Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard | Nature | 2013 | 23619691 | No |
| 3620 | 2367 | 1183.5 | 76.8 | 38.4 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
| 3621 | 2367 | 1183.5 | 57.1 | 28.6 | Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. | Sophia Y Lunt, Matthew G Vander Heiden | Annu Rev Cell Dev Biol | 2011 | 21985671 | No |
| 3622 | 1183 | 1183.0 | 35.5 | 35.5 | The Danish Cancer Registry. | Marianne Lundkjaer Gjerstorff | Scand J Public Health | 2011 | 21775350 | Yes |
| 3623 | 2365 | 1182.5 | 72.8 | 36.4 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
| 3624 | 2365 | 1182.5 | 85.0 | 42.5 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3625 | 2365 | 1182.5 | 42.7 | 21.4 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3626 | 2365 | 1182.5 | 58.8 | 29.4 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | No |
| 3627 | 4729 | 1182.2 | 209.6 | 52.4 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | No |
| 3628 | 1182 | 1182.0 | 52.9 | 52.9 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3629 | 1182 | 1182.0 | 21.3 | 21.3 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
| 3630 | 1182 | 1182.0 | 45.8 | 45.8 | Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). | Laura J Julian | Arthritis Care Res (Hoboken) | 2011 | 22588767 | No |
| 3631 | 3545 | 1181.7 | 113.2 | 37.7 | The Danish National Patient Register. | Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka Rebolj | Scand J Public Health | 2011 | 21775347 | Yes |
| 3632 | 2362 | 1181.0 | 64.4 | 32.2 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
| 3633 | 1181 | 1181.0 | 36.8 | 36.8 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
| 3634 | 1181 | 1181.0 | 53.0 | 53.0 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3635 | 1181 | 1181.0 | 30.7 | 30.7 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3636 | 1181 | 1181.0 | 26.7 | 26.7 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3637 | 1181 | 1181.0 | 26.3 | 26.3 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3638 | 1181 | 1181.0 | 33.8 | 33.8 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bunzli | Chem Rev | 2010 | 20151630 | No |
| 3639 | 5901 | 1180.2 | 262.9 | 52.6 | VSEARCH: a versatile open source tool for metagenomics. | Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic Mahe | PeerJ | 2016 | 27781170 | Yes |
| 3640 | 1180 | 1180.0 | 34.3 | 34.3 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
| 3641 | 1180 | 1180.0 | 23.7 | 23.7 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3642 | 1180 | 1180.0 | 43.2 | 43.2 | Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. | Walter S Leal | Annu Rev Entomol | 2013 | 23020622 | No |
| 3643 | 2358 | 1179.0 | 50.5 | 25.2 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
| 3644 | 1179 | 1179.0 | 38.9 | 38.9 | The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. | Peter C Austin | Stat Med | 2014 | 24122911 | Yes |
| 3645 | 1178 | 1178.0 | 39.4 | 39.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3646 | 1178 | 1178.0 | 57.4 | 57.4 | Resin composite--state of the art. | Jack L Ferracane | Dent Mater | 2011 | 21093034 | No |
| 3647 | 1178 | 1178.0 | 29.6 | 29.6 | The complex world of WNT receptor signalling. | Christof Niehrs | Nat Rev Mol Cell Biol | 2012 | 23151663 | No |
| 3648 | 2355 | 1177.5 | 80.4 | 40.2 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
| 3649 | 2351 | 1175.5 | 49.2 | 24.6 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3650 | 1175 | 1175.0 | 26.1 | 26.1 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
| 3651 | 1175 | 1175.0 | 11.6 | 11.6 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3652 | 1175 | 1175.0 | 34.8 | 34.8 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | No |
| 3653 | 1174 | 1174.0 | 31.7 | 31.7 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
| 3654 | 2348 | 1174.0 | 66.9 | 33.5 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
| 3655 | 2348 | 1174.0 | 43.3 | 21.6 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
| 3656 | 1174 | 1174.0 | 24.1 | 24.1 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
| 3657 | 1174 | 1174.0 | 32.3 | 32.3 | Cellular and molecular mechanisms of renal fibrosis. | Youhua Liu | Nat Rev Nephrol | 2011 | 22009250 | No |
| 3658 | 1173 | 1173.0 | 33.7 | 33.7 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 3659 | 1173 | 1173.0 | 26.2 | 26.2 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 3660 | 5865 | 1173.0 | 113.7 | 22.7 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3661 | 1173 | 1173.0 | 28.7 | 28.7 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | No |
| 3662 | 2346 | 1173.0 | 59.1 | 29.6 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | No |
| 3663 | 3517 | 1172.3 | 99.1 | 33.0 | AMPK: a nutrient and energy sensor that maintains energy homeostasis. | D Grahame Hardie, Fiona A Ross, Simon A Hawley | Nat Rev Mol Cell Biol | 2012 | 22436748 | No |
| 3664 | 1172 | 1172.0 | 51.8 | 51.8 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3665 | 2343 | 1171.5 | 62.5 | 31.2 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3666 | 3513 | 1171.0 | 141.4 | 47.1 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3667 | 1171 | 1171.0 | 34.9 | 34.9 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
| 3668 | 1171 | 1171.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B REXED | J Comp Neurol | 1952 | 14946260 | Yes |
| 3669 | 1171 | 1171.0 | 30.8 | 30.8 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3670 | 3513 | 1171.0 | 69.1 | 23.0 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. | Juri Rappsilber, Matthias Mann, Yasushi Ishihama | Nat Protoc | 2007 | 17703201 | Yes |
| 3671 | 1171 | 1171.0 | 39.1 | 39.1 | Constructive and unconstructive repetitive thought. | Edward R Watkins | Psychol Bull | 2008 | 18298268 | No |
| 3672 | 2342 | 1171.0 | 59.1 | 29.6 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | No |
| 3673 | 1170 | 1170.0 | 42.7 | 42.7 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
| 3674 | 1170 | 1170.0 | 32.3 | 32.3 | Normal bone anatomy and physiology. | Bart Clarke | Clin J Am Soc Nephrol | 2008 | 18988698 | No |
| 3675 | 1170 | 1170.0 | 33.9 | 33.9 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | No |
| 3676 | 1169 | 1169.0 | 33.9 | 33.9 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3677 | 1169 | 1169.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3678 | 1168 | 1168.0 | 31.2 | 31.2 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 3679 | 1168 | 1168.0 | 21.6 | 21.6 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
| 3680 | 1168 | 1168.0 | 29.4 | 29.4 | Gibberellin metabolism and its regulation. | Shinjiro Yamaguchi | Annu Rev Plant Biol | 2008 | 18173378 | No |
| 3681 | 2336 | 1168.0 | 89.7 | 44.9 | Shared decision making--pinnacle of patient-centered care. | Michael J Barry, Susan Edgman-Levitan | N Engl J Med | 2012 | 22375967 | Yes |
| 3682 | 18683 | 1167.7 | 684.0 | 42.8 | SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. | Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner | J Comput Biol | 2012 | 22506599 | Yes |
| 3683 | 2335 | 1167.5 | 50.3 | 25.1 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | No |
| 3684 | 1167 | 1167.0 | 24.5 | 24.5 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3685 | 1167 | 1167.0 | 35.1 | 35.1 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 3686 | 1167 | 1167.0 | 29.6 | 29.6 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
| 3687 | 2334 | 1167.0 | 56.9 | 28.4 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | No |
| 3688 | 1167 | 1167.0 | 32.0 | 32.0 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | No |
| 3689 | 12835 | 1166.8 | 418.8 | 38.1 | A global reference for human genetic variation. | , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R Abecasis | Nature | 2015 | 26432245 | Yes |
| 3690 | 3500 | 1166.7 | 80.4 | 26.8 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Vinuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3691 | 3498 | 1166.0 | 135.9 | 45.3 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3692 | 1166 | 1166.0 | 26.6 | 26.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
| 3693 | 1166 | 1166.0 | 20.4 | 20.4 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3694 | 1166 | 1166.0 | 35.2 | 35.2 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | No |
| 3695 | 5829 | 1165.8 | 164.8 | 33.0 | Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. | Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G Altman | PLoS Biol | 2010 | 20613859 | No |
| 3696 | 2331 | 1165.5 | 46.9 | 23.4 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3697 | 1165 | 1165.0 | 31.4 | 31.4 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 3698 | 1165 | 1165.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B BROWN | Biochem J | 1955 | 14389222 | Yes |
| 3699 | 1165 | 1165.0 | 34.8 | 34.8 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3700 | 2329 | 1164.5 | 69.4 | 34.7 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3701 | 1164 | 1164.0 | 20.6 | 20.6 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
| 3702 | 1164 | 1164.0 | 30.4 | 30.4 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3703 | 2328 | 1164.0 | 55.8 | 27.9 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3704 | 1164 | 1164.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J FAIRBANK | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3705 | 2327 | 1163.5 | 61.4 | 30.7 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3706 | 1163 | 1163.0 | 41.6 | 41.6 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3707 | 1163 | 1163.0 | 27.2 | 27.2 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3708 | 1163 | 1163.0 | 24.2 | 24.2 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3709 | 1163 | 1163.0 | 22.1 | 22.1 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3710 | 1163 | 1163.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E BULBRING | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3711 | 3488 | 1162.7 | 135.5 | 45.2 | Rheumatoid arthritis. | Josef S Smolen, Daniel Aletaha, Iain B McInnes | Lancet | 2016 | 27156434 | No |
| 3712 | 5810 | 1162.0 | 184.8 | 37.0 | A simulation study of the number of events per variable in logistic regression analysis. | P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein | J Clin Epidemiol | 1996 | 8970487 | Yes |
| 3713 | 1162 | 1162.0 | 32.6 | 32.6 | Targeting the DNA Damage Response in Cancer. | Mark J O'Connor | Mol Cell | 2015 | 26590714 | No |
| 3714 | 2322 | 1161.0 | 66.8 | 33.4 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3715 | 1161 | 1161.0 | 19.3 | 19.3 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3716 | 1161 | 1161.0 | 25.3 | 25.3 | What is principal component analysis? | Markus Ringner | Nat Biotechnol | 2008 | 18327243 | Yes |
| 3717 | 6963 | 1160.5 | 178.4 | 29.7 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3718 | 2321 | 1160.5 | 86.0 | 43.0 | Epidemiology of adult fractures: A review. | Charles M Court-Brown, Ben Caesar | Injury | 2006 | 16814787 | No |
| 3719 | 1160 | 1160.0 | 21.2 | 21.2 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
| 3720 | 1160 | 1160.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J VAGUE | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3721 | 2320 | 1160.0 | 46.0 | 23.0 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | No |
| 3722 | 2320 | 1160.0 | 57.4 | 28.7 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nunez | Nat Rev Immunol | 2010 | 21088683 | No |
| 3723 | 2319 | 1159.5 | 58.9 | 29.4 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
| 3724 | 2319 | 1159.5 | 56.6 | 28.3 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | Laetitia Prut, Catherine Belzung | Eur J Pharmacol | 2003 | 12600700 | No |
| 3725 | 2318 | 1159.0 | 50.7 | 25.4 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 3726 | 1159 | 1159.0 | 30.6 | 30.6 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | No |
| 3727 | 1159 | 1159.0 | 24.6 | 24.6 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | No |
| 3728 | 4634 | 1158.5 | 174.7 | 43.7 | The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. | L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg | Arch Neurol | 1989 | 2803071 | Yes |
| 3729 | 2317 | 1158.5 | 131.7 | 65.8 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W BUTCHER, E W SUTHERLAND | J Biol Chem | 1962 | 13875173 | Yes |
| 3730 | 2317 | 1158.5 | 57.1 | 28.6 | Monocyte recruitment during infection and inflammation. | Chao Shi, Eric G Pamer | Nat Rev Immunol | 2011 | 21984070 | No |
| 3731 | 4633 | 1158.2 | 107.7 | 26.9 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3732 | 1158 | 1158.0 | 42.3 | 42.3 | View through a window may influence recovery from surgery. | R S Ulrich | Science | 1984 | 6143402 | Yes |
| 3733 | 1158 | 1158.0 | 37.4 | 37.4 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 3734 | 1158 | 1158.0 | 39.4 | 39.4 | Microbial life in the phyllosphere. | Julia A Vorholt | Nat Rev Microbiol | 2012 | 23154261 | No |
| 3735 | 2315 | 1157.5 | 70.1 | 35.0 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
| 3736 | 3472 | 1157.3 | 72.8 | 24.3 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3737 | 6944 | 1157.3 | 174.6 | 29.1 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3738 | 2314 | 1157.0 | 77.0 | 38.5 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudas | N Engl J Med | 1992 | 1307234 | Yes |
| 3739 | 1157 | 1157.0 | 28.1 | 28.1 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3740 | 1157 | 1157.0 | 20.9 | 20.9 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
| 3741 | 1157 | 1157.0 | 33.2 | 33.2 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | No |
| 3742 | 2313 | 1156.5 | 49.1 | 24.6 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | No |
| 3743 | 2313 | 1156.5 | 87.3 | 43.6 | Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). | Marta Kutas, Kara D Federmeier | Annu Rev Psychol | 2011 | 20809790 | No |
| 3744 | 3469 | 1156.3 | 83.7 | 27.9 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3745 | 1156 | 1156.0 | 30.9 | 30.9 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
| 3746 | 1156 | 1156.0 | 24.3 | 24.3 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3747 | 1156 | 1156.0 | 33.5 | 33.5 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
| 3748 | 2311 | 1155.5 | 66.8 | 33.4 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
| 3749 | 2311 | 1155.5 | 50.1 | 25.1 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3750 | 2310 | 1155.0 | 53.3 | 26.6 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3751 | 1155 | 1155.0 | 45.1 | 45.1 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3752 | 2310 | 1155.0 | 51.6 | 25.8 | Efficient behavior of small-world networks. | V Latora, M Marchiori | Phys Rev Lett | 2001 | 11690461 | Yes |
| 3753 | 1155 | 1155.0 | 27.1 | 27.1 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | No |
| 3754 | 1155 | 1155.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R VANE | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3755 | 1155 | 1155.0 | 21.9 | 21.9 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 3756 | 1155 | 1155.0 | 0.0 | 0.0 | A new microscopic principle. | D GABOR | Nature | 1948 | 18860291 | Yes |
| 3757 | 1155 | 1155.0 | 27.6 | 27.6 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
| 3758 | 3465 | 1155.0 | 159.0 | 53.0 | The NLRP3 inflammasome: molecular activation and regulation to therapeutics. | Karen V Swanson, Meng Deng, Jenny P-Y Ting | Nat Rev Immunol | 2019 | 31036962 | No |
| 3759 | 3463 | 1154.3 | 101.1 | 33.7 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3760 | 2308 | 1154.0 | 60.5 | 30.2 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3761 | 1154 | 1154.0 | 23.9 | 23.9 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3762 | 2308 | 1154.0 | 45.2 | 22.6 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
| 3763 | 2308 | 1154.0 | 73.3 | 36.6 | Positive psychology. An introduction. | M E Seligman, M Csikszentmihalyi | Am Psychol | 2000 | 11392865 | Yes |
| 3764 | 1154 | 1154.0 | 22.9 | 22.9 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
| 3765 | 3462 | 1154.0 | 117.5 | 39.2 | The weirdest people in the world? | Joseph Henrich, Steven J Heine, Ara Norenzayan | Behav Brain Sci | 2010 | 20550733 | Yes |
| 3766 | 2306 | 1153.0 | 46.0 | 23.0 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 3767 | 2306 | 1153.0 | 47.5 | 23.8 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. | Javier A Menendez, Ruth Lupu | Nat Rev Cancer | 2007 | 17882277 | No |
| 3768 | 2306 | 1153.0 | 113.8 | 56.9 | Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. | Laura M Doyle, Michael Zhuo Wang | Cells | 2019 | 31311206 | No |
| 3769 | 2305 | 1152.5 | 41.1 | 20.6 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | No |
| 3770 | 2305 | 1152.5 | 102.8 | 51.4 | Neurobiology of addiction: a neurocircuitry analysis. | George F Koob, Nora D Volkow | Lancet Psychiatry | 2016 | 27475769 | No |
| 3771 | 1152 | 1152.0 | 32.5 | 32.5 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
| 3772 | 1152 | 1152.0 | 28.6 | 28.6 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
| 3773 | 1152 | 1152.0 | 38.0 | 38.0 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
| 3774 | 1152 | 1152.0 | 34.4 | 34.4 | Recommended effect size statistics for repeated measures designs. | Roger Bakeman | Behav Res Methods | 2005 | 16405133 | Yes |
| 3775 | 1152 | 1152.0 | 45.0 | 45.0 | Root canal irrigants. | Matthias Zehnder | J Endod | 2006 | 16631834 | No |
| 3776 | 3456 | 1152.0 | 114.7 | 38.2 | The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. | Stefka Tyanova, Tikira Temu, Juergen Cox | Nat Protoc | 2016 | 27809316 | Yes |
| 3777 | 1152 | 1152.0 | 39.6 | 39.6 | T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. | Shane Crotty | Immunity | 2019 | 31117010 | No |
| 3778 | 2303 | 1151.5 | 48.5 | 24.2 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3779 | 3454 | 1151.3 | 87.6 | 29.2 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3780 | 2302 | 1151.0 | 46.7 | 23.4 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3781 | 1151 | 1151.0 | 23.2 | 23.2 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
| 3782 | 1151 | 1151.0 | 20.5 | 20.5 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3783 | 1151 | 1151.0 | 28.9 | 28.9 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | No |
| 3784 | 1151 | 1151.0 | 44.1 | 44.1 | Reference methods for the assessment of physical characteristics of meat. | K O Honikel | Meat Sci | 1998 | 22060626 | Yes |
| 3785 | 1150 | 1150.0 | 32.3 | 32.3 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3786 | 1150 | 1150.0 | 23.8 | 23.8 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 3787 | 1150 | 1150.0 | 21.7 | 21.7 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
| 3788 | 1150 | 1150.0 | 26.2 | 26.2 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3789 | 1150 | 1150.0 | 20.1 | 20.1 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 3790 | 1150 | 1150.0 | 39.7 | 39.7 | Development of the practice environment scale of the Nursing Work Index. | Eileen T Lake | Res Nurs Health | 2002 | 12015780 | Yes |
| 3791 | 1150 | 1150.0 | 24.2 | 24.2 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | No |
| 3792 | 3450 | 1150.0 | 76.7 | 25.6 | STATs in cancer inflammation and immunity: a leading role for STAT3. | Hua Yu, Drew Pardoll, Richard Jove | Nat Rev Cancer | 2009 | 19851315 | No |
| 3793 | 1150 | 1150.0 | 32.2 | 32.2 | Conceptual synthesis in community ecology. | Mark Vellend | Q Rev Biol | 2010 | 20565040 | No |
| 3794 | 2300 | 1150.0 | 74.7 | 37.4 | Glycosylation in cancer: mechanisms and clinical implications. | Salome S Pinho, Celso A Reis | Nat Rev Cancer | 2015 | 26289314 | No |
| 3795 | 1150 | 1150.0 | 59.7 | 59.7 | Cisplatin: The first metal based anticancer drug. | Sumit Ghosh | Bioorg Chem | 2019 | 31003078 | No |
| 3796 | 5747 | 1149.4 | 196.5 | 39.3 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Open Med | 2009 | 21603045 | Yes |
| 3797 | 3448 | 1149.3 | 81.3 | 27.1 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | No |
| 3798 | 1149 | 1149.0 | 40.7 | 40.7 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3799 | 1149 | 1149.0 | 32.0 | 32.0 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
| 3800 | 1149 | 1149.0 | 36.7 | 36.7 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
| 3801 | 1149 | 1149.0 | 27.0 | 27.0 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | No |
| 3802 | 1149 | 1149.0 | 41.5 | 41.5 | Surface-enhanced Raman spectroscopy: concepts and chemical applications. | Sebastian Schlucker | Angew Chem Int Ed Engl | 2014 | 24711218 | Yes |
| 3803 | 2297 | 1148.5 | 44.4 | 22.2 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 3804 | 2297 | 1148.5 | 91.8 | 45.9 | The aggression questionnaire. | A H Buss, M Perry | J Pers Soc Psychol | 1992 | 1403624 | Yes |
| 3805 | 4594 | 1148.5 | 146.0 | 36.5 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
| 3806 | 1148 | 1148.0 | 34.3 | 34.3 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3807 | 1148 | 1148.0 | 44.1 | 44.1 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3808 | 1148 | 1148.0 | 31.3 | 31.3 | Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. | A E Black | Int J Obes Relat Metab Disord | 2000 | 11033980 | Yes |
| 3809 | 6887 | 1147.8 | 186.5 | 31.1 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3810 | 4590 | 1147.5 | 109.4 | 27.4 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 3811 | 4589 | 1147.2 | 34.1 | 8.5 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLME | Lancet | 1963 | 13990765 | Yes |
| 3812 | 1147 | 1147.0 | 21.5 | 21.5 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
| 3813 | 1147 | 1147.0 | 21.7 | 21.7 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 3814 | 1147 | 1147.0 | 31.1 | 31.1 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3815 | 2294 | 1147.0 | 59.2 | 29.6 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 3816 | 1147 | 1147.0 | 29.5 | 29.5 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | No |
| 3817 | 1147 | 1147.0 | 24.0 | 24.0 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 3818 | 20643 | 1146.8 | 487.8 | 27.1 | PHENIX: a comprehensive Python-based system for macromolecular structure solution. | Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart | Acta Crystallogr D Biol Crystallogr | 2010 | 20124702 | Yes |
| 3819 | 2293 | 1146.5 | 45.3 | 22.6 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
| 3820 | 2293 | 1146.5 | 63.5 | 31.8 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3821 | 1146 | 1146.0 | 33.0 | 33.0 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3822 | 2292 | 1146.0 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C TRUELOVE, L J WITTS | Br Med J | 1955 | 13260656 | Yes |
| 3823 | 1146 | 1146.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
| 3824 | 3437 | 1145.7 | 123.6 | 41.2 | Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. | Michael A Postow, Robert Sidlow, Matthew D Hellmann | N Engl J Med | 2018 | 29320654 | No |
| 3825 | 2291 | 1145.5 | 63.2 | 31.6 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H. Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3826 | 3435 | 1145.0 | 90.9 | 30.3 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3827 | 1145 | 1145.0 | 26.1 | 26.1 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3828 | 1145 | 1145.0 | 26.6 | 26.6 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | No |
| 3829 | 1145 | 1145.0 | 24.0 | 24.0 | Pyramidal neurons: dendritic structure and synaptic integration. | Nelson Spruston | Nat Rev Neurosci | 2008 | 18270515 | No |
| 3830 | 2289 | 1144.5 | 88.4 | 44.2 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3831 | 2289 | 1144.5 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H USSING, K ZERAHN | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3832 | 2289 | 1144.5 | 58.3 | 29.1 | Cu-catalyzed azide-alkyne cycloaddition. | Morten Meldal, Christian Wenzel Tornoe | Chem Rev | 2008 | 18698735 | No |
| 3833 | 4577 | 1144.2 | 97.9 | 24.5 | Isolation and characterization of exosomes from cell culture supernatants and biological fluids. | Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled Clayton | Curr Protoc Cell Biol | 2006 | 18228490 | Yes |
| 3834 | 3431 | 1143.7 | 119.0 | 39.7 | IL-6 in inflammation, immunity, and disease. | Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto | Cold Spring Harb Perspect Biol | 2014 | 25190079 | No |
| 3835 | 2287 | 1143.5 | 64.5 | 32.2 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | No |
| 3836 | 2287 | 1143.5 | 53.5 | 26.8 | Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Bioinformatics | 2007 | 17050570 | Yes |
| 3837 | 2287 | 1143.5 | 97.0 | 48.5 | Network analysis: an integrative approach to the structure of psychopathology. | Denny Borsboom, Angelique O J Cramer | Annu Rev Clin Psychol | 2013 | 23537483 | No |
| 3838 | 1143 | 1143.0 | 43.5 | 43.5 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3839 | 1143 | 1143.0 | 28.5 | 28.5 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 3840 | 1143 | 1143.0 | 20.5 | 20.5 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 3841 | 1143 | 1143.0 | 31.9 | 31.9 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 3842 | 1143 | 1143.0 | 43.2 | 43.2 | A comprehensive review on metabolic syndrome. | Jaspinder Kaur | Cardiol Res Pract | 2014 | 24711954 | No |
| 3843 | 3427 | 1142.3 | 111.1 | 37.0 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 3844 | 1142 | 1142.0 | 33.8 | 33.8 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3845 | 2284 | 1142.0 | 85.5 | 42.8 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3846 | 1142 | 1142.0 | 17.0 | 17.0 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O EGEBERG | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3847 | 5710 | 1142.0 | 150.3 | 30.1 | A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi | Cell | 2011 | 21802130 | Yes |
| 3848 | 2283 | 1141.5 | 289.4 | 144.7 | The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. | Karin E de Visser, Johanna A Joyce | Cancer Cell | 2023 | 36917948 | No |
| 3849 | 7990 | 1141.4 | 135.8 | 19.4 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3850 | 1141 | 1141.0 | 22.8 | 22.8 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 3851 | 1141 | 1141.0 | 28.9 | 28.9 | Electrogenerated chemiluminescence and its biorelated applications. | Wujian Miao | Chem Rev | 2008 | 18505298 | No |
| 3852 | 1141 | 1141.0 | 125.2 | 125.2 | Sample size determination and power analysis using the G*Power software. | Hyun Kang | J Educ Eval Health Prof | 2021 | 34325496 | No |
| 3853 | 2281 | 1140.5 | 55.6 | 27.8 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | No |
| 3854 | 1140 | 1140.0 | 34.4 | 34.4 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
| 3855 | 2280 | 1140.0 | 72.3 | 36.1 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3856 | 1140 | 1140.0 | 23.6 | 23.6 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
| 3857 | 1140 | 1140.0 | 29.6 | 29.6 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3858 | 1140 | 1140.0 | 67.9 | 67.9 | Diffusion-in-gel methods for immunological analysis. II. | O OUCHTERLONY | Prog Allergy | 1962 | 14482809 | Yes |
| 3859 | 1140 | 1140.0 | 26.0 | 26.0 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3860 | 1140 | 1140.0 | 31.9 | 31.9 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | No |
| 3861 | 1140 | 1140.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D HOTCHKISS | Arch Biochem | 1948 | 18921848 | Yes |
| 3862 | 1140 | 1140.0 | 45.1 | 45.1 | Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. | Hannah R Snyder | Psychol Bull | 2013 | 22642228 | No |
| 3863 | 1140 | 1140.0 | 43.2 | 43.2 | Epithelial Mesenchymal Transition in Tumor Metastasis. | Vivek Mittal | Annu Rev Pathol | 2018 | 29414248 | No |
| 3864 | 1139 | 1139.0 | 18.6 | 18.6 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3865 | 1139 | 1139.0 | 27.2 | 27.2 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | No |
| 3866 | 1139 | 1139.0 | 16.3 | 16.3 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J PENNINGTON | Biochem J | 1961 | 13734134 | Yes |
| 3867 | 1139 | 1139.0 | 37.7 | 37.7 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | No |
| 3868 | 1139 | 1139.0 | 23.9 | 23.9 | The action potential in mammalian central neurons. | Bruce P Bean | Nat Rev Neurosci | 2007 | 17514198 | No |
| 3869 | 2277 | 1138.5 | 137.1 | 68.5 | Modified reagents for determination of urea and ammonia. | A L CHANEY, E P MARBACH | Clin Chem | 1962 | 13878063 | Yes |
| 3870 | 2276 | 1138.0 | 88.1 | 44.0 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3871 | 1138 | 1138.0 | 27.6 | 27.6 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | No |
| 3872 | 1138 | 1138.0 | 26.9 | 26.9 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3873 | 1138 | 1138.0 | 27.0 | 27.0 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3874 | 1138 | 1138.0 | 25.9 | 25.9 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 3875 | 1138 | 1138.0 | 25.1 | 25.1 | Pathogenesis of atherosclerosis. | Erling Falk | J Am Coll Cardiol | 2006 | 16631513 | Yes |
| 3876 | 1138 | 1138.0 | 32.3 | 32.3 | The social brain in adolescence. | Sarah-Jayne Blakemore | Nat Rev Neurosci | 2008 | 18354399 | No |
| 3877 | 1138 | 1138.0 | 26.3 | 26.3 | Ab-initio simulations of materials using VASP: Density-functional theory and beyond. | Jurgen Hafner | J Comput Chem | 2008 | 18623101 | Yes |
| 3878 | 2275 | 1137.5 | 41.0 | 20.5 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3879 | 1137 | 1137.0 | 81.3 | 81.3 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3880 | 2274 | 1137.0 | 85.3 | 42.6 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3881 | 2274 | 1137.0 | 59.3 | 29.6 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massague | J Biol Chem | 1986 | 3456347 | Yes |
| 3882 | 1137 | 1137.0 | 39.9 | 39.9 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
| 3883 | 1137 | 1137.0 | 24.9 | 24.9 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 3884 | 2274 | 1137.0 | 65.5 | 32.8 | Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. | R J Ginsberg, L V Rubinstein | Ann Thorac Surg | 1995 | 7677489 | Yes |
| 3885 | 4548 | 1137.0 | 103.8 | 25.9 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 3886 | 1137 | 1137.0 | 23.1 | 23.1 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | No |
| 3887 | 2272 | 1136.0 | 52.6 | 26.3 | A note on quantifying follow-up in studies of failure time. | M Schemper, T L Smith | Control Clin Trials | 1996 | 8889347 | Yes |
| 3888 | 1136 | 1136.0 | 25.7 | 25.7 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Wurthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3889 | 2272 | 1136.0 | 54.2 | 27.1 | The neural basis of decision making. | Joshua I Gold, Michael N Shadlen | Annu Rev Neurosci | 2007 | 17600525 | No |
| 3890 | 1136 | 1136.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3891 | 3407 | 1135.7 | 64.4 | 21.5 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3892 | 2271 | 1135.5 | 70.4 | 35.2 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | No |
| 3893 | 2271 | 1135.5 | 80.8 | 40.4 | Ferroptosis: Death by Lipid Peroxidation. | Wan Seok Yang, Brent R Stockwell | Trends Cell Biol | 2016 | 26653790 | No |
| 3894 | 4541 | 1135.2 | 199.9 | 50.0 | Random effects structure for confirmatory hypothesis testing: Keep it maximal. | Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily | J Mem Lang | 2013 | 24403724 | Yes |
| 3895 | 1135 | 1135.0 | 34.6 | 34.6 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 3896 | 1135 | 1135.0 | 20.9 | 20.9 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
| 3897 | 3405 | 1135.0 | 80.5 | 26.8 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. | Chun-Chi Liang, Ann Y Park, Jun-Lin Guan | Nat Protoc | 2007 | 17406593 | Yes |
| 3898 | 1135 | 1135.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O SCHILD | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 3899 | 1135 | 1135.0 | 46.4 | 46.4 | How Many Subjects Does It Take To Do A Regression Analysis. | S B Green | Multivariate Behav Res | 1991 | 26776715 | Yes |
| 3900 | 3402 | 1134.0 | 93.1 | 31.0 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 3901 | 1134 | 1134.0 | 37.7 | 37.7 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
| 3902 | 1134 | 1134.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L LEKSELL | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3903 | 1134 | 1134.0 | 25.2 | 25.2 | Mucins in cancer: function, prognosis and therapy. | Donald W Kufe | Nat Rev Cancer | 2009 | 19935676 | No |
| 3904 | 1134 | 1134.0 | 35.7 | 35.7 | Biomedical photoacoustic imaging. | Paul Beard | Interface Focus | 2011 | 22866233 | Yes |
| 3905 | 5668 | 1133.6 | 200.0 | 40.0 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3906 | 2267 | 1133.5 | 65.1 | 32.5 | Genome-wide efficient mixed-model analysis for association studies. | Xiang Zhou, Matthew Stephens | Nat Genet | 2012 | 22706312 | Yes |
| 3907 | 2266 | 1133.0 | 99.4 | 49.7 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3908 | 1133 | 1133.0 | 22.6 | 22.6 | Alpha-synuclein and neurodegenerative diseases. | M Goedert | Nat Rev Neurosci | 2001 | 11433374 | No |
| 3909 | 1133 | 1133.0 | 27.0 | 27.0 | Omega-3 fatty acids in inflammation and autoimmune diseases. | Artemis P Simopoulos | J Am Coll Nutr | 2002 | 12480795 | No |
| 3910 | 1133 | 1133.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W WHITE | Psychol Rev | 1959 | 13844397 | Yes |
| 3911 | 2265 | 1132.5 | 53.6 | 26.8 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3912 | 2265 | 1132.5 | 55.9 | 27.9 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 3913 | 1132 | 1132.0 | 34.5 | 34.5 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
| 3914 | 1132 | 1132.0 | 55.7 | 55.7 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3915 | 1132 | 1132.0 | 20.2 | 20.2 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3916 | 1132 | 1132.0 | 25.2 | 25.2 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3917 | 1132 | 1132.0 | 27.4 | 27.4 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
| 3918 | 1131 | 1131.0 | 69.3 | 69.3 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 3919 | 1131 | 1131.0 | 33.2 | 33.2 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 3920 | 1131 | 1131.0 | 19.1 | 19.1 | 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. | Judith K Christman | Oncogene | 2002 | 12154409 | No |
| 3921 | 1131 | 1131.0 | 27.0 | 27.0 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | No |
| 3922 | 3392 | 1130.7 | 72.5 | 24.2 | Mitochondria, oxidants, and aging. | Robert S Balaban, Shino Nemoto, Toren Finkel | Cell | 2005 | 15734681 | No |
| 3923 | 1130 | 1130.0 | 39.8 | 39.8 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 3924 | 1130 | 1130.0 | 23.5 | 23.5 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
| 3925 | 2260 | 1130.0 | 45.1 | 22.6 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 3926 | 1130 | 1130.0 | 42.6 | 42.6 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
| 3927 | 1130 | 1130.0 | 31.3 | 31.3 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 3928 | 1130 | 1130.0 | 24.1 | 24.1 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
| 3929 | 1130 | 1130.0 | 26.5 | 26.5 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | No |
| 3930 | 2259 | 1129.5 | 81.0 | 40.5 | The blood-brain barrier. | Richard Daneman, Alexandre Prat | Cold Spring Harb Perspect Biol | 2015 | 25561720 | No |
| 3931 | 2259 | 1129.5 | 161.0 | 80.5 | TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. | Jan P Meier-Kolthoff, Markus Goker | Nat Commun | 2019 | 31097708 | Yes |
| 3932 | 1129 | 1129.0 | 28.6 | 28.6 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 3933 | 1129 | 1129.0 | 32.2 | 32.2 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 3934 | 1129 | 1129.0 | 27.9 | 27.9 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 3935 | 1129 | 1129.0 | 43.3 | 43.3 | Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. | Peter J Barnes | J Allergy Clin Immunol | 2016 | 27373322 | No |
| 3936 | 1128 | 1128.0 | 11.5 | 11.5 | Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. | J J Hopfield | Proc Natl Acad Sci U S A | 1974 | 4530290 | Yes |
| 3937 | 1128 | 1128.0 | 20.3 | 20.3 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
| 3938 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B STAVITSKY | J Immunol | 1954 | 13163409 | Yes |
| 3939 | 1128 | 1128.0 | 30.1 | 30.1 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | No |
| 3940 | 2256 | 1128.0 | 63.6 | 31.8 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | No |
| 3941 | 1128 | 1128.0 | 33.6 | 33.6 | The enteric nervous system and neurogastroenterology. | John B Furness | Nat Rev Gastroenterol Hepatol | 2012 | 22392290 | No |
| 3942 | 2256 | 1128.0 | 113.6 | 56.8 | Cytokine Storm. | David C Fajgenbaum, Carl H June | N Engl J Med | 2020 | 33264547 | No |
| 3943 | 2255 | 1127.5 | 36.4 | 18.2 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 3944 | 1127 | 1127.0 | 27.9 | 27.9 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
| 3945 | 1127 | 1127.0 | 24.5 | 24.5 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 3946 | 2254 | 1127.0 | 79.5 | 39.8 | Perceived discrimination and health: a meta-analytic review. | Elizabeth A Pascoe, Laura Smart Richman | Psychol Bull | 2009 | 19586161 | Yes |
| 3947 | 1126 | 1126.0 | 26.6 | 26.6 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 3948 | 1126 | 1126.0 | 21.7 | 21.7 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
| 3949 | 1126 | 1126.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J DEESE | J Exp Psychol | 1959 | 13664879 | Yes |
| 3950 | 1126 | 1126.0 | 24.8 | 24.8 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | No |
| 3951 | 1126 | 1126.0 | 26.9 | 26.9 | Hybridization as an invasion of the genome. | James Mallet | Trends Ecol Evol | 2005 | 16701374 | Yes |
| 3952 | 1126 | 1126.0 | 27.2 | 27.2 | Telomere length measurement by a novel monochrome multiplex quantitative PCR method. | Richard M Cawthon | Nucleic Acids Res | 2009 | 19129229 | Yes |
| 3953 | 2251 | 1125.5 | 48.7 | 24.4 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 3954 | 1125 | 1125.0 | 49.4 | 49.4 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
| 3955 | 1125 | 1125.0 | 40.8 | 40.8 | An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. | F G Happe | J Autism Dev Disord | 1994 | 8040158 | Yes |
| 3956 | 2249 | 1124.5 | 95.4 | 47.7 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 3957 | 1124 | 1124.0 | 27.8 | 27.8 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
| 3958 | 1124 | 1124.0 | 33.9 | 33.9 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 3959 | 1124 | 1124.0 | 21.2 | 21.2 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
| 3960 | 2248 | 1124.0 | 52.1 | 26.1 | The oxytocin receptor system: structure, function, and regulation. | G Gimpl, F Fahrenholz | Physiol Rev | 2001 | 11274341 | No |
| 3961 | 3371 | 1123.7 | 119.1 | 39.7 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 3962 | 11231 | 1123.1 | 393.8 | 39.4 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | PLoS Med | 2009 | 19621070 | No |
| 3963 | 1123 | 1123.0 | 55.5 | 55.5 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
| 3964 | 1123 | 1123.0 | 41.4 | 41.4 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 3965 | 1123 | 1123.0 | 33.0 | 33.0 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
| 3966 | 1123 | 1123.0 | 36.6 | 36.6 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3967 | 4492 | 1123.0 | 84.5 | 21.1 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3968 | 1123 | 1123.0 | 24.0 | 24.0 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 3969 | 1123 | 1123.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A EASTERBROOK | Psychol Rev | 1959 | 13658305 | Yes |
| 3970 | 1123 | 1123.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W SPERRY | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 3971 | 1123 | 1123.0 | 30.1 | 30.1 | Innate immunity of fish (overview). | Bergljot Magnadottir | Fish Shellfish Immunol | 2006 | 15950491 | No |
| 3972 | 1123 | 1123.0 | 28.4 | 28.4 | Descending pathways in motor control. | Roger N Lemon | Annu Rev Neurosci | 2008 | 18558853 | No |
| 3973 | 2246 | 1123.0 | 62.4 | 31.2 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 3974 | 4490 | 1122.5 | 115.3 | 28.8 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 3975 | 1122 | 1122.0 | 39.6 | 39.6 | Perceptual selectivity for color and form. | J Theeuwes | Percept Psychophys | 1992 | 1620571 | No |
| 3976 | 1122 | 1122.0 | 35.6 | 35.6 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 3977 | 1122 | 1122.0 | 29.6 | 29.6 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 3978 | 1122 | 1122.0 | 23.2 | 23.2 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 3979 | 1122 | 1122.0 | 23.0 | 23.0 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 3980 | 1122 | 1122.0 | 18.5 | 18.5 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 3981 | 1122 | 1122.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B REXED | J Comp Neurol | 1954 | 13163236 | Yes |
| 3982 | 1122 | 1122.0 | 25.8 | 25.8 | NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. | Weihai Ying | Antioxid Redox Signal | 2008 | 18020963 | No |
| 3983 | 1122 | 1122.0 | 30.0 | 30.0 | Voltage-gated calcium channels. | William A Catterall | Cold Spring Harb Perspect Biol | 2011 | 21746798 | No |
| 3984 | 1122 | 1122.0 | 68.9 | 68.9 | Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. | Cheng-Hsien Li | Behav Res Methods | 2016 | 26174714 | Yes |
| 3985 | 1121 | 1121.0 | 36.4 | 36.4 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 3986 | 2242 | 1121.0 | 46.7 | 23.4 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 3987 | 1121 | 1121.0 | 25.8 | 25.8 | The emotional brain, fear, and the amygdala. | Joseph LeDoux | Cell Mol Neurobiol | 2003 | 14514027 | No |
| 3988 | 2241 | 1120.5 | 52.6 | 26.3 | The NF-kappaB family of transcription factors and its regulation. | Andrea Oeckinghaus, Sankar Ghosh | Cold Spring Harb Perspect Biol | 2009 | 20066092 | No |
| 3989 | 1120 | 1120.0 | 25.3 | 25.3 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
| 3990 | 1120 | 1120.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 3991 | 1119 | 1119.0 | 30.5 | 30.5 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
| 3992 | 1119 | 1119.0 | 37.1 | 37.1 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
| 3993 | 2238 | 1119.0 | 58.5 | 29.2 | DNA methylation: roles in mammalian development. | Zachary D Smith, Alexander Meissner | Nat Rev Genet | 2013 | 23400093 | No |
| 3994 | 2237 | 1118.5 | 26.4 | 13.2 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P GOLD, S O FREEDMAN | J Exp Med | 1965 | 14270243 | Yes |
| 3995 | 2237 | 1118.5 | 79.4 | 39.7 | NAFLD: a multisystem disease. | Christopher D Byrne, Giovanni Targher | J Hepatol | 2015 | 25920090 | No |
| 3996 | 2236 | 1118.0 | 53.9 | 26.9 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 3997 | 1118 | 1118.0 | 28.2 | 28.2 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
| 3998 | 1118 | 1118.0 | 31.7 | 31.7 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | No |
| 3999 | 1118 | 1118.0 | 27.0 | 27.0 | Biological effects of resveratrol. | L Fremont | Life Sci | 2000 | 10680575 | No |
| 4000 | 1118 | 1118.0 | 21.7 | 21.7 | Automated NMR structure calculation with CYANA. | Peter Guntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 4001 | 1118 | 1118.0 | 20.6 | 20.6 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
| 4002 | 2236 | 1118.0 | 53.5 | 26.8 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | No |
| 4003 | 4471 | 1117.8 | 154.4 | 38.6 | Development of recommendations for SEMG sensors and sensor placement procedures. | H J Hermens, B Freriks, C Disselhorst-Klug, G Rau | J Electromyogr Kinesiol | 2000 | 11018445 | Yes |
| 4004 | 2235 | 1117.5 | 52.4 | 26.2 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral, | Lancet | 2003 | 12927427 | Yes |
| 4005 | 4470 | 1117.5 | 113.7 | 28.4 | REVIGO summarizes and visualizes long lists of gene ontology terms. | Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav Smuc | PLoS One | 2011 | 21789182 | Yes |
| 4006 | 1117 | 1117.0 | 32.6 | 32.6 | Spontaneous dissection of the carotid and vertebral arteries. | W I Schievink | N Engl J Med | 2001 | 11259724 | No |
| 4007 | 2234 | 1117.0 | 32.2 | 16.1 | Microdroplet Assay Of Human Serum Cytotoxins. | P I TERASAKI, J D MCCLELLAND | Nature | 1964 | 14248725 | Yes |
| 4008 | 2234 | 1117.0 | 88.1 | 44.0 | Global estimates of visual impairment: 2010. | Donatella Pascolini, Silvio Paolo Mariotti | Br J Ophthalmol | 2012 | 22133988 | Yes |
| 4009 | 4467 | 1116.8 | 140.3 | 35.1 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 4010 | 2233 | 1116.5 | 65.8 | 32.9 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 4011 | 2233 | 1116.5 | 108.8 | 54.4 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 4012 | 3349 | 1116.3 | 188.5 | 62.8 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 4013 | 1116 | 1116.0 | 36.8 | 36.8 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
| 4014 | 1116 | 1116.0 | 29.5 | 29.5 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 4015 | 1116 | 1116.0 | 22.5 | 22.5 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | No |
| 4016 | 1116 | 1116.0 | 26.3 | 26.3 | Soil carbon sequestration impacts on global climate change and food security. | R Lal | Science | 2004 | 15192216 | Yes |
| 4017 | 1116 | 1116.0 | 31.9 | 31.9 | The broaden-and-build theory of positive emotions. | Barbara L Fredrickson | Philos Trans R Soc Lond B Biol Sci | 2004 | 15347528 | No |
| 4018 | 2231 | 1115.5 | 46.5 | 23.2 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | No |
| 4019 | 2230 | 1115.0 | 44.0 | 22.0 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Karre | Immunol Today | 1990 | 2201309 | No |
| 4020 | 3345 | 1115.0 | 134.1 | 44.7 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 4021 | 1115 | 1115.0 | 13.3 | 13.3 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 4022 | 1115 | 1115.0 | 20.4 | 20.4 | Cytokines in cancer pathogenesis and cancer therapy. | Glenn Dranoff | Nat Rev Cancer | 2004 | 14708024 | No |
| 4023 | 1115 | 1115.0 | 35.0 | 35.0 | Vitamin D status: measurement, interpretation, and clinical application. | Michael F Holick | Ann Epidemiol | 2009 | 18329892 | No |
| 4024 | 4458 | 1114.5 | 118.5 | 29.6 | A role for mitochondria in NLRP3 inflammasome activation. | Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg Tschopp | Nature | 2011 | 21124315 | Yes |
| 4025 | 2228 | 1114.0 | 56.5 | 28.2 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. | L Pellerin, P J Magistretti | Proc Natl Acad Sci U S A | 1994 | 7938003 | Yes |
| 4026 | 1114 | 1114.0 | 32.1 | 32.1 | Image matching as a diffusion process: an analogy with Maxwell's demons. | J P Thirion | Med Image Anal | 1998 | 9873902 | Yes |
| 4027 | 6682 | 1113.7 | 149.5 | 24.9 | Alpha-synuclein in Lewy bodies. | M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert | Nature | 1997 | 9278044 | Yes |
| 4028 | 2227 | 1113.5 | 61.5 | 30.8 | Flexible regression models with cubic splines. | S Durrleman, R Simon | Stat Med | 1989 | 2657958 | Yes |
| 4029 | 2227 | 1113.5 | 45.7 | 22.9 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 4030 | 4453 | 1113.2 | 113.3 | 28.3 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 4031 | 14470 | 1113.1 | 378.9 | 29.1 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , | JAMA | 2003 | 12748199 | No |
| 4032 | 1113 | 1113.0 | 28.0 | 28.0 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
| 4033 | 2226 | 1113.0 | 69.5 | 34.8 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
| 4034 | 2226 | 1113.0 | 52.5 | 26.2 | CpG islands and the regulation of transcription. | Aimee M Deaton, Adrian Bird | Genes Dev | 2011 | 21576262 | No |
| 4035 | 1113 | 1113.0 | 36.3 | 36.3 | Supramolecular binding thermodynamics by dispersion-corrected density functional theory. | Stefan Grimme | Chemistry | 2012 | 22782805 | Yes |
| 4036 | 1113 | 1113.0 | 41.4 | 41.4 | Fiber and prebiotics: mechanisms and health benefits. | Joanne Slavin | Nutrients | 2013 | 23609775 | No |
| 4037 | 1113 | 1113.0 | 37.9 | 37.9 | Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. | Gyorgy Buzsaki | Hippocampus | 2015 | 26135716 | No |
| 4038 | 1113 | 1113.0 | 35.6 | 35.6 | Targeting metastasis. | Patricia S Steeg | Nat Rev Cancer | 2016 | 27009393 | No |
| 4039 | 4450 | 1112.5 | 102.2 | 25.6 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 4040 | 2225 | 1112.5 | 49.1 | 24.6 | How to interpret LC3 immunoblotting. | Noboru Mizushima, Tamotsu Yoshimori | Autophagy | 2007 | 17611390 | No |
| 4041 | 1112 | 1112.0 | 23.2 | 23.2 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 4042 | 2224 | 1112.0 | 54.4 | 27.2 | Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. | D Rice, S Barone | Environ Health Perspect | 2000 | 10852851 | No |
| 4043 | 4447 | 1111.8 | 108.2 | 27.1 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 4044 | 3335 | 1111.7 | 109.9 | 36.6 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 4045 | 1111 | 1111.0 | 22.2 | 22.2 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | No |
| 4046 | 2222 | 1111.0 | 53.6 | 26.8 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 4047 | 1111 | 1111.0 | 13.8 | 13.8 | The evolutionary advantage of recombination. | J Felsenstein | Genetics | 1974 | 4448362 | Yes |
| 4048 | 1111 | 1111.0 | 41.5 | 41.5 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
| 4049 | 1111 | 1111.0 | 21.7 | 21.7 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | No |
| 4050 | 1111 | 1111.0 | 25.5 | 25.5 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
| 4051 | 1111 | 1111.0 | 32.4 | 32.4 | The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. | R Charon | JAMA | 2001 | 11597295 | Yes |
| 4052 | 2222 | 1111.0 | 45.6 | 22.8 | An energy budget for signaling in the grey matter of the brain. | D Attwell, S B Laughlin | J Cereb Blood Flow Metab | 2001 | 11598490 | No |
| 4053 | 2222 | 1111.0 | 53.7 | 26.9 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief Bioinform | 2008 | 18372315 | Yes |
| 4054 | 2221 | 1110.5 | 77.4 | 38.7 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
| 4055 | 2221 | 1110.5 | 82.7 | 41.4 | The structure of psychological well-being revisited. | C D Ryff, C L Keyes | J Pers Soc Psychol | 1995 | 7473027 | Yes |
| 4056 | 2221 | 1110.5 | 60.1 | 30.1 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N Engl J Med | 2007 | 17652652 | Yes |
| 4057 | 4442 | 1110.5 | 133.8 | 33.5 | Causal analysis approaches in Ingenuity Pathway Analysis. | Andreas Kramer, Jeff Green, Jack Pollard, Stuart Tugendreich | Bioinformatics | 2014 | 24336805 | Yes |
| 4058 | 1110 | 1110.0 | 61.8 | 61.8 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
| 4059 | 1110 | 1110.0 | 22.4 | 22.4 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
| 4060 | 1110 | 1110.0 | 21.6 | 21.6 | Unfolding the role of protein misfolding in neurodegenerative diseases. | Claudio Soto | Nat Rev Neurosci | 2003 | 12511861 | No |
| 4061 | 1110 | 1110.0 | 25.9 | 25.9 | Area deprivation and widening inequalities in US mortality, 1969-1998. | Gopal K Singh | Am J Public Health | 2003 | 12835199 | Yes |
| 4062 | 1110 | 1110.0 | 21.0 | 21.0 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat Rev Genet | 2007 | 17304246 | No |
| 4063 | 2220 | 1110.0 | 69.8 | 34.9 | Intestinal epithelial cells: regulators of barrier function and immune homeostasis. | Lance W Peterson, David Artis | Nat Rev Immunol | 2014 | 24566914 | No |
| 4064 | 1110 | 1110.0 | 57.1 | 57.1 | COVID-19: immunopathology and its implications for therapy. | Xuetao Cao | Nat Rev Immunol | 2020 | 32273594 | Yes |
| 4065 | 4439 | 1109.8 | 159.4 | 39.9 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 4066 | 5549 | 1109.8 | 271.6 | 54.3 | UFBoot2: Improving the Ultrafast Bootstrap Approximation. | Diep Thi Hoang, Olga Chernomor, Arndt von Haeseler, Bui Quang Minh, Le Sy Vinh | Mol Biol Evol | 2018 | 29077904 | Yes |
| 4067 | 3329 | 1109.7 | 108.5 | 36.2 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 4068 | 2219 | 1109.5 | 54.9 | 27.4 | A general purpose model for the condensed phases of water: TIP4P/2005. | J L F Abascal, C Vega | J Chem Phys | 2005 | 16392929 | Yes |
| 4069 | 1109 | 1109.0 | 25.8 | 25.8 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 4070 | 1109 | 1109.0 | 35.2 | 35.2 | Mental illness and/or mental health? Investigating axioms of the complete state model of health. | Corey L M Keyes | J Consult Clin Psychol | 2005 | 15982151 | Yes |
| 4071 | 1109 | 1109.0 | 22.9 | 22.9 | The molecular biology of coronaviruses. | Paul S Masters | Adv Virus Res | 2006 | 16877062 | No |
| 4072 | 1109 | 1109.0 | 31.2 | 31.2 | Cytochrome p450 and chemical toxicology. | F Peter Guengerich | Chem Res Toxicol | 2008 | 18052394 | No |
| 4073 | 3327 | 1109.0 | 91.6 | 30.5 | Foreign body reaction to biomaterials. | James M Anderson, Analiz Rodriguez, David T Chang | Semin Immunol | 2008 | 18162407 | No |
| 4074 | 2217 | 1108.5 | 64.9 | 32.5 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 4075 | 4432 | 1108.0 | 149.1 | 37.3 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 4076 | 1108 | 1108.0 | 44.6 | 44.6 | The epidemiology and impact of pain in osteoarthritis. | T Neogi | Osteoarthritis Cartilage | 2013 | 23973124 | Yes |
| 4077 | 2215 | 1107.5 | 64.7 | 32.4 | Stool form scale as a useful guide to intestinal transit time. | S J Lewis, K W Heaton | Scand J Gastroenterol | 1997 | 9299672 | Yes |
| 4078 | 1107 | 1107.0 | 45.3 | 45.3 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | No |
| 4079 | 1107 | 1107.0 | 23.8 | 23.8 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat Rev Neurosci | 2000 | 11252767 | No |
| 4080 | 1107 | 1107.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W TEALE | Biochim Biophys Acta | 1959 | 13837237 | Yes |
| 4081 | 1107 | 1107.0 | 22.6 | 22.6 | Large-scale recording of neuronal ensembles. | Gyorgy Buzsaki | Nat Neurosci | 2004 | 15114356 | No |
| 4082 | 1107 | 1107.0 | 23.2 | 23.2 | The self-tuning neuron: synaptic scaling of excitatory synapses. | Gina G Turrigiano | Cell | 2008 | 18984155 | No |
| 4083 | 5534 | 1106.8 | 115.1 | 23.0 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
| 4084 | 1106 | 1106.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H KASS | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 4085 | 1106 | 1106.0 | 48.0 | 48.0 | Fibromyalgia: a clinical review. | Daniel J Clauw | JAMA | 2014 | 24737367 | No |
| 4086 | 2211 | 1105.5 | 71.7 | 35.9 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 4087 | 2211 | 1105.5 | 38.2 | 19.1 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 4088 | 2211 | 1105.5 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H COONS, M H KAPLAN | J Exp Med | 1950 | 15395569 | Yes |
| 4089 | 2210 | 1105.0 | 48.6 | 24.3 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | No |
| 4090 | 1105 | 1105.0 | 24.7 | 24.7 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | No |
| 4091 | 1105 | 1105.0 | 30.8 | 30.8 | Lanthanide-based luminescent hybrid materials. | Koen Binnemans | Chem Rev | 2009 | 19650663 | Yes |
| 4092 | 2209 | 1104.5 | 58.3 | 29.1 | The cerebellar cognitive affective syndrome. | J D Schmahmann, J C Sherman | Brain | 1998 | 9577385 | Yes |
| 4093 | 4418 | 1104.5 | 175.8 | 44.0 | From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. | Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik Backhed | Cell | 2016 | 27259147 | No |
| 4094 | 1104 | 1104.0 | 29.8 | 29.8 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | No |
| 4095 | 1104 | 1104.0 | 27.3 | 27.3 | Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. | Jill E Clarridge | Clin Microbiol Rev | 2004 | 15489351 | No |
| 4096 | 6623 | 1103.8 | 164.4 | 27.4 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 4097 | 2207 | 1103.5 | 49.0 | 24.5 | Mechanisms of endocytosis. | Gary J Doherty, Harvey T McMahon | Annu Rev Biochem | 2009 | 19317650 | No |
| 4098 | 1103 | 1103.0 | 32.6 | 32.6 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 4099 | 1103 | 1103.0 | 22.0 | 22.0 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 4100 | 1103 | 1103.0 | 21.6 | 21.6 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | No |
| 4101 | 2206 | 1103.0 | 49.2 | 24.6 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | No |
| 4102 | 1103 | 1103.0 | 32.4 | 32.4 | The Delphi technique: myths and realities. | Catherine Powell | J Adv Nurs | 2003 | 12581103 | No |
| 4103 | 1103 | 1103.0 | 31.7 | 31.7 | Outer membrane permeability and antibiotic resistance. | Anne H Delcour | Biochim Biophys Acta | 2009 | 19100346 | No |
| 4104 | 1103 | 1103.0 | 23.5 | 23.5 | Cells of origin in cancer. | Jane E Visvader | Nature | 2011 | 21248838 | No |
| 4105 | 2205 | 1102.5 | 63.3 | 31.6 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | No |
| 4106 | 2205 | 1102.5 | 45.1 | 22.6 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | No |
| 4107 | 2205 | 1102.5 | 47.6 | 23.8 | p21 in cancer: intricate networks and multiple activities. | Tarek Abbas, Anindya Dutta | Nat Rev Cancer | 2009 | 19440234 | No |
| 4108 | 2204 | 1102.0 | 64.4 | 32.2 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
| 4109 | 2204 | 1102.0 | 65.5 | 32.8 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | No |
| 4110 | 1102 | 1102.0 | 22.9 | 22.9 | Ligand-targeted therapeutics in anticancer therapy. | Theresa M Allen | Nat Rev Cancer | 2002 | 12360278 | No |
| 4111 | 1102 | 1102.0 | 23.0 | 23.0 | Evolution of the neocortex: a perspective from developmental biology. | Pasko Rakic | Nat Rev Neurosci | 2009 | 19763105 | No |
| 4112 | 2204 | 1102.0 | 75.6 | 37.8 | Loneliness matters: a theoretical and empirical review of consequences and mechanisms. | Louise C Hawkley, John T Cacioppo | Ann Behav Med | 2010 | 20652462 | No |
| 4113 | 2204 | 1102.0 | 65.8 | 32.9 | The human microbiome: at the interface of health and disease. | Ilseung Cho, Martin J Blaser | Nat Rev Genet | 2012 | 22411464 | No |
| 4114 | 4407 | 1101.8 | 108.4 | 27.1 | Wound repair and regeneration. | Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T Longaker | Nature | 2008 | 18480812 | No |
| 4115 | 1101 | 1101.0 | 26.9 | 26.9 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
| 4116 | 1101 | 1101.0 | 37.6 | 37.6 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 4117 | 1101 | 1101.0 | 20.6 | 20.6 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
| 4118 | 1101 | 1101.0 | 41.9 | 41.9 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | No |
| 4119 | 1101 | 1101.0 | 33.7 | 33.7 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | No |
| 4120 | 1101 | 1101.0 | 24.1 | 24.1 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | No |
| 4121 | 1101 | 1101.0 | 24.9 | 24.9 | Marine viruses and their biogeochemical and ecological effects. | J A Fuhrman | Nature | 1999 | 10376593 | No |
| 4122 | 1101 | 1101.0 | 33.3 | 33.3 | Molecular pathogenesis and mechanisms of thyroid cancer. | Mingzhao Xing | Nat Rev Cancer | 2013 | 23429735 | No |
| 4123 | 2202 | 1101.0 | 122.0 | 61.0 | miRDB: an online database for prediction of functional microRNA targets. | Yuhao Chen, Xiaowei Wang | Nucleic Acids Res | 2020 | 31504780 | Yes |
| 4124 | 5504 | 1100.8 | 213.3 | 42.7 | MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. | Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah Lam | Bioinformatics | 2015 | 25609793 | Yes |
| 4125 | 3302 | 1100.7 | 102.3 | 34.1 | xCell: digitally portraying the tissue cellular heterogeneity landscape. | Dvir Aran, Zicheng Hu, Atul J Butte | Genome Biol | 2017 | 29141660 | Yes |
| 4126 | 2201 | 1100.5 | 89.4 | 44.7 | Emotional processing of fear: exposure to corrective information. | E B Foa, M J Kozak | Psychol Bull | 1986 | 2871574 | Yes |
| 4127 | 7703 | 1100.4 | 671.6 | 95.9 | The psychological impact of quarantine and how to reduce it: rapid review of the evidence. | Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin | Lancet | 2020 | 32112714 | No |
| 4128 | 1100 | 1100.0 | 20.5 | 20.5 | The immune response of Drosophila. | Jules A Hoffmann | Nature | 2003 | 14603309 | No |
| 4129 | 1100 | 1100.0 | 27.7 | 27.7 | Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. | Paul H Yancey | J Exp Biol | 2005 | 16043587 | No |
| 4130 | 1100 | 1100.0 | 34.4 | 34.4 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 4131 | 2199 | 1099.5 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E VAN HANDEL, D B ZILVERSMIT | J Lab Clin Med | 1957 | 13439279 | Yes |
| 4132 | 1099 | 1099.0 | 18.9 | 18.9 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | No |
| 4133 | 1099 | 1099.0 | 25.2 | 25.2 | Biochemistry and genetics of von Willebrand factor. | J E Sadler | Annu Rev Biochem | 1998 | 9759493 | No |
| 4134 | 1099 | 1099.0 | 23.8 | 23.8 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | No |
| 4135 | 1099 | 1099.0 | 18.2 | 18.2 | The concept of synthetic lethality in the context of anticancer therapy. | William G Kaelin | Nat Rev Cancer | 2005 | 16110319 | No |
| 4136 | 1099 | 1099.0 | 26.5 | 26.5 | Sleep-dependent memory consolidation. | Robert Stickgold | Nature | 2005 | 16251952 | No |
| 4137 | 1099 | 1099.0 | 25.9 | 25.9 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4138 | 2198 | 1099.0 | 76.0 | 38.0 | Coronaviruses: an overview of their replication and pathogenesis. | Anthony R Fehr, Stanley Perlman | Methods Mol Biol | 2015 | 25720466 | No |
| 4139 | 2198 | 1099.0 | 85.1 | 42.5 | Mechanism and medical implications of mammalian autophagy. | Ivan Dikic, Zvulun Elazar | Nat Rev Mol Cell Biol | 2018 | 29618831 | No |
| 4140 | 2197 | 1098.5 | 59.6 | 29.8 | Collagen structure and stability. | Matthew D Shoulders, Ronald T Raines | Annu Rev Biochem | 2009 | 19344236 | No |
| 4141 | 1098 | 1098.0 | 18.8 | 18.8 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
| 4142 | 2196 | 1098.0 | 34.8 | 17.4 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | No |
| 4143 | 2195 | 1097.5 | 57.2 | 28.6 | Reactive oxygen species in cancer. | Geou-Yarh Liou, Peter Storz | Free Radic Res | 2010 | 20370557 | No |
| 4144 | 5487 | 1097.4 | 139.9 | 28.0 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4145 | 1097 | 1097.0 | 20.6 | 20.6 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
| 4146 | 1097 | 1097.0 | 20.1 | 20.1 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | No |
| 4147 | 1097 | 1097.0 | 34.6 | 34.6 | Designing cell-compatible hydrogels for biomedical applications. | Dror Seliktar | Science | 2012 | 22654050 | No |
| 4148 | 2193 | 1096.5 | 68.1 | 34.0 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | No |
Download as CSV