Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 4127 papers with ECcit ≥ 1090.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 63, November 2025

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1226138226138.04714.34714.3Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2181008181008.07370.37370.3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328817772044.20.00.0Protein measurement with the Folin phenol reagent. O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALLJ Biol Chem195114907713Yes
413745868729.03359.21679.6Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54663246632.01372.51372.5A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63863838638.01241.41241.4Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76474232371.01931.0965.5Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83026330263.0810.7810.7Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92952429524.0682.2682.2MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
102938529385.0924.1924.1The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
112898928989.0624.6624.6MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
122751327513.0699.3699.3A rating scale for depression. M HAMILTONJ Neurol Neurosurg Psychiatry196014399272Yes
132633826338.0595.2595.2A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142541525415.0791.4791.4Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
154745123725.51393.5696.8Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
166978323261.02503.3834.4"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
172314923149.0623.6623.6Projector augmented-wave method. P E BlochlPhys Rev B Condens Matter19949976227Yes
186638822129.31632.7544.2DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
192182321823.0738.2738.2Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
204181020905.01289.3644.6The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
216139920466.32124.2708.1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
222045920459.0204.1204.1The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S REYNOLDSJ Cell Biol196313986422Yes
232043920439.00.00.0Tissue sulfhydryl groups. G L ELLMANArch Biochem Biophys195913650640Yes
243965519827.51605.7802.9The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
251959219592.0763.9763.9RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
263792118960.51761.8880.9Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
273782818914.01129.6564.8Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
285634518781.71620.2540.1Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
291838318383.0674.6674.6A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
301828218282.0745.7745.7A power primer. J CohenPsychol Bull199219565683Yes
315365117883.72029.4676.5Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
323534017670.0859.3429.6Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
331732317323.0427.7427.7Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
341690516905.0768.5768.5Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
351677316773.0283.1283.1Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DAVISAnn N Y Acad Sci196414240539Yes
363349416747.00.00.0A rapid method of total lipid extraction and purification. E G BLIGH, W J DYERCan J Biochem Physiol195913671378Yes
373323016615.01307.9654.0The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
381622616226.0443.0443.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
391614316143.0389.0389.0MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
401601116011.0612.6612.6Catalase in vitro. H AebiMethods Enzymol19846727660Yes
413197015985.01184.8592.4Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
421593615936.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BURTONBiochem J195613293190Yes
433150215751.0838.5419.2Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmullerPhys Rev B Condens Matter19969984901Yes
444638715462.31315.3438.4CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
454321014403.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J FOLCH, M LEES, G H SLOANE STANLEYJ Biol Chem195713428781Yes
461419614196.0532.5532.5Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
474240414134.71527.0509.0Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
481387313873.0336.2336.2Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
492724813624.0546.2273.1Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
502712013560.0720.1360.1Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
516779713559.41934.6386.9Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
521353713537.0448.6448.6Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
531341713417.0604.7604.7Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
541336313363.0404.7404.7Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
552666713333.5953.8476.9MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
561321213212.0394.4394.4The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
572635713178.51060.9530.5The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
583931913106.31360.1453.4Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
591283712837.0148.7148.7The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
602549512747.5540.1270.1KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
611265912659.00.00.0Phosphorus assay in column chromatography. G R BARTLETTJ Biol Chem195913641241Yes
623774312581.0972.4324.1VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
631251612516.0518.9518.9Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
641251112511.0408.6408.6Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
653706012353.31176.2392.1NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
661205612056.0451.5451.5A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
672402112010.5515.2257.6Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
684663011657.51301.6325.4Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
691137211372.0506.6506.6SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
702220311101.5925.3462.6The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
711099510995.0277.6277.6Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
721084710847.0354.4354.4Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
732156310781.5555.7277.9A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
741071610716.00.00.0On the origin of cancer cells. O WARBURGScience195613298683Yes
751046010460.0439.7439.7Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
761038310383.0282.6282.6The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
771031010310.0201.1201.1Improvements in epoxy resin embedding methods. J H LUFTJ Biophys Biochem Cytol196113764136Yes
781023610236.0289.6289.6Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
794085610214.01476.4369.1A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
804032810082.01287.7321.9Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
811007110071.0203.6203.6Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
823005610018.7862.9287.6The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
83198169908.0356.3178.2The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
84296949898.0752.5250.8edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
85197319865.5578.1289.1AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
8698319831.0230.1230.1PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
87196469823.0499.6249.8Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
8898189818.0272.5272.5Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
89194629731.0498.8249.4A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
9097199719.0380.6380.6UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
9197149714.0249.7249.7Canonical dynamics: Equilibrium phase-space distributions. WG HooverPhys Rev A Gen Phys19859895674Yes
9296399639.0316.8316.8Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
9396149614.0242.4242.4RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
94191119555.5390.8195.4The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
9595149514.0250.9250.9Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
96284069468.7697.2232.4Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9794279427.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
9893639363.0237.3237.3Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
99186529326.0424.9212.4BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
10092549254.0261.0261.0Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
101184849242.0392.4196.2Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10292159215.0236.1236.1Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
10392109210.0257.7257.7The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
104273109103.31344.1448.0MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
10590909090.0231.9231.9Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
106452559051.01676.5335.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, PLoS Med200919621072No
10789918991.0176.7176.7Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
10889208920.0259.5259.5AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
10988978897.00.00.0The assessment of anxiety states by rating. M HAMILTONBr J Med Psychol195913638508Yes
110177908895.0581.3290.6Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
111355178879.21136.4284.1G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
11288498849.0183.2183.2The functions of animal microRNAs. Victor AmbrosNature200415372042No
113174718735.5401.2200.6WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
11485808580.0389.9389.9Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
115255908530.0754.8251.6Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
11684788478.0348.4348.4Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
117169218460.51016.0508.0A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
118168328416.0374.8187.4Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11982718271.0223.5223.5Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
120247128237.3842.6280.9Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
12181398139.0195.2195.2Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
122162258112.5388.7194.3MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
12381098109.0196.1196.1Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12481088108.0339.3339.3Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
12579847984.0154.8154.8Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
12679837983.0247.9247.9The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
12779527952.0164.2164.2Chromatin modifications and their function. Tony KouzaridesCell200717320507No
12879257925.0218.3218.3"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
12979017901.0272.6272.6The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
13078737873.0225.4225.4A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
13178557855.0255.0255.0Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
13278057805.0214.7214.7The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
133233477782.3902.5300.8Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
13477547754.0230.8230.8The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
135154767738.0422.2211.1EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
13677337733.0221.5221.5Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BoyumScand J Clin Lab Invest Suppl19684179068Yes
13777167716.0218.4218.4Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
138531767596.61351.9193.1Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
13975787578.0245.5245.5An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
14075737573.0193.3193.3A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
141150597529.5398.2199.1RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
14273997399.0119.2119.2A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
143147947397.0377.4188.7Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
14470897089.0191.2191.2TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
145141647082.0772.6386.3Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14670777077.00.00.0Index for rating diagnostic tests. W J YOUDENCancer195015405679Yes
147140047002.0349.1174.6Continuous cultures of fused cells secreting antibody of predefined specificity. G Kohler, C MilsteinNature19751172191Yes
148138566928.0467.5233.8Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
14968796879.0114.7114.7A Self-Rating Depression Scale. W W ZUNGArch Gen Psychiatry196514221692Yes
15068626862.0182.8182.8The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
15168106810.0132.1132.1Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
15267486748.0153.1153.1Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
15367176717.0216.7216.7Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
15467166716.0199.6199.6Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
15567136713.00.00.0The thiobarbituric acid assay of sialic acids. L WARRENJ Biol Chem195913672998Yes
156133866693.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N MANTEL, W HAENSZELJ Natl Cancer Inst195913655060Yes
15766916691.0153.2153.2Inflammation, atherosclerosis, and coronary artery disease. Goran K HanssonN Engl J Med200515843671No
158133236661.5310.1155.1Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
159132336616.5444.8222.4The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
16066056605.0168.9168.9Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
161198026600.7552.3184.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
16265786578.0169.9169.9Adhesion receptors of the immune system. T A SpringerNature19901974032No
16365586558.0153.1153.1Inflammation and metabolic disorders. Gokhan S HotamisligilNature200617167474No
164195306510.0974.2324.7Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16564836483.0149.4149.4Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
166129606480.0530.2265.1Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
16764436443.0135.2135.2p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
16864336433.0147.4147.4Free radicals in the physiological control of cell function. Wulf DrogePhysiol Rev200211773609No
16964286428.0137.1137.1Inflammation in atherosclerosis. Peter LibbyNature200212490960No
17064196419.0128.9128.9Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
171383616393.51290.6215.1Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
17263776377.0116.8116.8BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
17363226322.0217.4217.4FreeSurfer. Bruce FischlNeuroimage201222248573No
17462966296.0273.3273.3Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
17562636263.0169.8169.8A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
176125216260.5336.6168.3Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
17762216221.0199.9199.9Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
17862156215.0140.1140.1Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
17961916191.0138.3138.3Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
180123456172.5262.5131.2One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
181123266163.0296.2148.1MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
182123256162.5280.7140.3Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
18361516151.0133.3133.3MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
184122816140.5444.7222.3A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
18561386138.077.777.7The Environment And Disease: Association Or Causation? A B HILLProc R Soc Med196514283879Yes
18660886088.0152.5152.5G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
18760846084.0146.9146.9Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
18860796079.0184.9184.9Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
18960566056.0151.2151.2Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
190239725993.0788.9197.2Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
191119095954.5456.4228.2phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
192118815940.5390.5195.2Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
193236435910.8674.0168.5clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
19458985898.0153.1153.1How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
19558635863.0141.7141.7Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
196116855842.5246.3123.2MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jurgen Cox, Matthias MannNat Biotechnol200819029910Yes
19758375837.0149.4149.4Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
198174965832.0537.2179.1featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
19958275827.0178.4178.4jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
20058235823.0229.5229.5Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
20158235823.0565.8565.8Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
202116385819.0283.1141.6Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
203232705817.5563.8140.9Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
20458025802.00.00.0Aging: a theory based on free radical and radiation chemistry. D HARMANJ Gerontol195613332224Yes
205115885794.0240.0120.0Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
206230465761.5681.6170.4A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
20757345734.0213.4213.4Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
20857345734.0142.4142.4Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
209114545727.0247.3123.7Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
210114545727.0193.596.8The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T OMURA, R SATOJ Biol Chem196414209971Yes
211171595719.7631.6210.5The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
21257155715.0119.2119.2Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
213114085704.00.00.0A series of normal stages in the development of the chick embryo. V HAMBURGER, H L HAMILTONJ Morphol195124539719Yes
214113875693.5742.0371.0Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
21556875687.095.195.1Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
21656715671.0213.8213.8The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
217112975648.5531.9265.9A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
218112235611.5255.8127.9A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stephane Guindon, Olivier GascuelSyst Biol200314530136Yes
21956035603.089.689.6Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
22055875587.0118.6118.6The biochemistry of apoptosis. M O HengartnerNature200011048727No
22155765576.0163.5163.5Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
222111445572.0293.9146.9Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
223167095569.7500.5166.8A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
224110485524.00.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L HODGKIN, A F HUXLEYJ Physiol195212991237Yes
225164355478.3642.5214.2A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
226164315477.0399.3133.1Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
227109305465.0284.7142.3Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
228163955465.0641.3213.8Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
22954305430.0103.4103.4Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
230107965398.0299.8149.9MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
23153915391.0135.8135.8The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
232107805390.0356.4178.2Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
23353875387.053.053.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LAURENActa Pathol Microbiol Scand196514320675Yes
234268255365.0718.7143.7The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
23553495349.0127.5127.5Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
23653395339.0104.2104.2Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
237106675333.5226.6113.3The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23853305330.0127.1127.1The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
23953075307.0134.8134.8New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
240106055302.5250.1125.0Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
24152835283.0233.1233.1Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniel LakensFront Psychol201324324449No
24252705270.0151.6151.6Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
24352295229.0188.7188.7Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
24452215221.00.00.0[A micro-method of immuno-electrophoresis]. J J SCHEIDEGGERInt Arch Allergy Appl Immunol195513262900Yes
245104205210.0179.389.7Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
24652035203.068.468.4Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
247103955197.5363.9181.9The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
248154935164.3539.8179.9HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
249103265163.0164.782.3Functional Evaluation: The Barthel Index. F I MAHONEY, D W BARTHELMd State Med J196514258950Yes
25051555155.0101.3101.3Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
251102785139.0271.7135.8Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schagger, G von JagowAnal Biochem19872449095Yes
25251395139.0155.7155.7Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
253256905138.01039.3207.9MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
25451135113.0187.5187.5Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
255102075103.5264.2132.1The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
256153095103.0501.7167.2HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
25750985098.0144.5144.5Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
258101805090.0357.1178.6Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
25950785078.0122.7122.7The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
260101515075.5237.7118.8A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
261150975032.3474.6158.2Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
262251335026.6421.284.2An inventory for measuring depression. A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGHArch Gen Psychiatry196113688369Yes
263150755025.0654.6218.2Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
26450185018.091.791.7DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
265149874995.7540.1180.0Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
26699084954.0223.1111.5Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26749494949.0123.3123.3A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
268196964924.0315.078.8A new and rapid colorimetric determination of acetylcholinesterase activity. G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONEBiochem Pharmacol196113726518Yes
26949124912.0156.0156.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
270195964899.0608.9152.2A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LoweArch Intern Med200616717171Yes
27197844892.0348.6174.3Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
27248854885.097.397.3An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
273146544884.7392.6130.9Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
27448814881.0113.2113.2Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
27596874843.5354.1177.1The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
276145144838.00.00.0Determination of serum proteins by means of the biuret reaction. A G GORNALL, C J BARDAWILL, M M DAVIDJ Biol Chem194918110453Yes
27748374837.0204.7204.7The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
27848194819.0104.0104.0Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
27948184818.0107.3107.3ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
280144434814.3355.6118.5A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
28148104810.0104.5104.5Cancer cell cycles. C J SherrScience19968939849No
282336644809.1727.1103.9UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
28396184809.0227.8113.9Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
28448084808.057.557.5Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RODBELLJ Biol Chem196414169133Yes
28547974797.040.540.5The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HAYFLICKExp Cell Res196514315085Yes
28695724786.0387.8193.9The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
287143404780.0309.0103.0Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
28847774777.0104.3104.3Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
28995254762.5158.879.4A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
29047384738.094.694.6Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
29194644732.0236.6118.3Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
29247094709.0264.8264.8Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BORNNature196213871375Yes
29347074707.0155.9155.9The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
29493844692.0136.268.1Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
29593654682.5233.5116.8Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
29693654682.50.00.0Radiological assessment of osteo-arthrosis. J H KELLGREN, J S LAWRENCEAnn Rheum Dis195713498604Yes
29746784678.0129.5129.5Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
298186934673.2521.9130.5MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
29946654665.0142.5142.5Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
30046564656.0120.3120.3A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
30146544654.048.948.9The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
30246444644.0127.0127.0Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
30392794639.5355.2177.6The qualitative content analysis process. Satu Elo, Helvi KyngasJ Adv Nurs200818352969Yes
30446254625.0171.6171.6Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
30592504625.0202.2101.1Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
30646244624.095.595.5Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
30792434621.5227.6113.8Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30892234611.5251.4125.7Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
309230184603.6870.7174.1The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
31046004600.0164.7164.7EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31145974597.091.491.4Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
312137904596.7472.1157.4Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
31345934593.0104.2104.2Cancer. p53, guardian of the genome. D P LaneNature19921614522No
31445784578.0133.0133.0DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
31591314565.5262.1131.1Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
31645504550.096.796.7ras genes. M BarbacidAnnu Rev Biochem19873304147No
31790874543.5241.0120.5A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
31890794539.5286.4143.2FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoc, Steven L SalzbergBioinformatics201121903629Yes
31990744537.0207.9104.0SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
32045234523.090.890.8Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
321135644521.3494.5164.8A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
32245164516.0163.1163.1A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
32345134513.086.786.7The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
32445054505.084.484.4The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
32544614461.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B DE B WEIRJ Physiol194915394301Yes
32644574457.0121.9121.9Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
32788984449.00.00.0A simplified method of evaluating dose-effect experiments. J T LITCHFIELD, F WILCOXONJ Pharmacol Exp Ther194918152921Yes
328266304438.3859.3143.2Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32944354435.0107.3107.3A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
33044204420.0133.8133.8How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
33144194419.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
332264864414.3917.3152.9MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
33344064406.0101.9101.9Mechanisms of angiogenesis. W RisauNature19979109485No
33444024402.0104.6104.6Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
33543954395.0111.3111.3A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
33687874393.5206.5103.2Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
33743934393.0110.7110.7Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
33843904390.093.093.0Atherosclerosis. A J LusisNature200011001066No
33987714385.5162.181.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
34043854385.0112.2112.2Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34143704370.090.890.8Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
34243534353.0221.5221.5Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
34343444344.0111.2111.2Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
34443354335.0128.1128.1Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
34586324316.0266.1133.1DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
34643144314.0118.7118.7The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
34786214310.5219.2109.6tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
34843024302.0108.7108.7Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
34985844292.0465.9232.9Preparation of iodine-131 labelled human growth hormone of high specific activity. W M HUNTER, F C GREENWOODNature196214450081Yes
35085694284.5225.4112.7Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35142814281.093.893.8PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
35242774277.0106.1106.1Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
35342764276.087.687.6The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
35442754275.00.00.0Estimation of nuclear population from microtome sections. M ABERCROMBIEAnat Rec194621015608Yes
35542744274.0112.7112.7The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
35642744274.091.591.5Apoptosis by death factor. S NagataCell19979039262No
35785434271.5213.8106.9Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
35842634263.075.575.5Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
35942614261.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NASHBiochem J195313105648Yes
360212974259.41234.4246.9MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
36142584258.0113.0113.0Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
36242494249.00.00.0Amino acid metabolism in mammalian cell cultures. H EAGLEScience195913675766Yes
36342494249.0141.3141.3Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36442454245.0171.4171.4A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
365424064240.61032.6103.3The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, Bioinformatics200919505943Yes
36642344234.0108.8108.8Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
36742324232.086.586.5The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
36842304230.050.150.1Bone: formation by autoinduction. M R UristScience19655319761Yes
36942224222.093.793.7Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
37042154215.0120.2120.2Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
37142144214.080.580.5Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
37242044204.073.373.3Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
37342024202.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DOLEJ Clin Invest195613286333Yes
37441974197.086.586.5Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
37541954195.0174.8174.8Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
37641874187.0100.4100.4The origins and the future of microfluidics. George M WhitesidesNature200616871203No
37741784178.0110.1110.1Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
378125324177.3318.2106.1Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
37941634163.00.00.0The determination of enzyme inhibitor constants. M DIXONBiochem J195313093635Yes
38083264163.0177.588.8Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
38183234161.5215.6107.8Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
38241564156.098.598.5RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
38341434143.085.885.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
38482824141.0177.188.5Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
38541404140.0111.4111.4Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
38641384138.0127.6127.6Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
38782574128.5192.696.3The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
388164364109.0366.391.6Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
38941034103.0100.1100.1Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
39040894089.0101.5101.5Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39140854085.0113.5113.5EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
39240824082.0116.3116.3Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
39340654065.0106.3106.3Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
39440654065.0142.5142.5KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
39540534053.0133.2133.2Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
39680934046.5195.097.5The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
39740274027.0102.9102.9Integrins: a family of cell surface receptors. R O HynesCell19873028640No
39840224022.091.091.0Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
399120654021.7322.3107.4Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
40080414020.5151.375.7A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
40140194019.0106.8106.8What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
40240154015.068.668.6Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
40340144014.081.881.8Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
40480204010.0150.875.4Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
405160244006.0565.6141.4Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
40640014001.0127.8127.8Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
40779903995.0196.698.3An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
40839843984.082.082.0Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
40939723972.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WATSONJ Biophys Biochem Cytol195813563554Yes
41039673967.086.886.8Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
41179193959.5259.5129.8Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
41239593959.095.095.0Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
413118743958.0279.493.1Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
41478873943.5211.7105.8BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41539413941.0112.5112.5What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41639343934.0141.7141.7You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
417157273931.8709.5177.4fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
41839273927.0113.0113.0adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
41978503925.0219.0109.5Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
42039203920.0120.2120.2Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
42139173917.064.064.0Disc Electrophoresis. I. Background And Theory. L ORNSTEINAnn N Y Acad Sci196414240533Yes
42239083908.0143.0143.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42339073907.0119.2119.2genepop'007: a complete re-implementation of the genepop software for Windows and Linux. Francois RoussetMol Ecol Resour200821585727Yes
42439003900.076.076.0Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
42538883888.0173.5173.5Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
42638873887.091.391.3Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
42738873887.0103.2103.2Graphene: status and prospects. A K GeimScience200919541989Yes
42838803880.0117.4117.4Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
42938753875.090.490.4I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
43038733873.0131.9131.9Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
43138723872.090.890.8Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
43238703870.0115.8115.8Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
43338683868.0109.2109.2Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
43438653865.088.688.6Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
43538623862.094.194.1How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
43638483848.098.398.3The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
437346213846.81034.4114.9STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
43838423842.0122.4122.4Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
43938283828.0102.3102.3Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
440267553822.1916.7131.0limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
441343143812.7726.680.7Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
44276163808.0180.990.5Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
44338083808.077.677.6TGF-beta signal transduction. J MassagueAnnu Rev Biochem19989759503No
44437993799.098.898.8Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
44537973797.079.379.3A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
44637963796.089.689.6Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrungerNature199218481394Yes
447113643788.0358.7119.6Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
448151363784.0613.5153.4IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
44937823782.0119.8119.8No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
45075463773.0163.481.7Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
45137573757.065.265.2Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
45275143757.0174.187.0Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
45337533753.0107.2107.2Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
45437503750.097.197.1The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
455112293743.0213.971.3Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
45637403740.090.790.7The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
45774773738.5376.1188.1Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
45874773738.5223.0111.5Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
45937363736.066.066.0Somatic generation of antibody diversity. S TonegawaNature19836300689No
46037193719.0165.4165.4The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
461111473715.7258.586.2Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
46237043704.068.468.4A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
46337013701.0101.7101.7Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
46437003700.076.576.5Profile hidden Markov models. S R EddyBioinformatics19989918945No
46572903645.0227.0113.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
46636393639.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MILLERPsychol Rev195613310704Yes
467181913638.2653.6130.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Ann Intern Med200919622511No
46836383638.0115.3115.3Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
46936353635.081.281.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
47072653632.5265.6132.8The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
47172543627.0128.564.2Translating the histone code. T Jenuwein, C D AllisScience200111498575No
47236263626.084.184.1Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
47372413620.5203.4101.7The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
47436193619.0166.1166.1Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
47536173617.071.071.0Mammalian neural stem cells. F H GageScience200010688783No
47636173617.080.080.0Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
47772323616.0364.4182.2Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H HUBEL, T N WIESELJ Physiol196214449617Yes
47836143614.0117.2117.2The Danish Civil Registration System. Carsten Bocker PedersenScand J Public Health201121775345Yes
47936103610.0108.1108.1Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
48072113605.5168.384.2Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
48136043604.054.954.9Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
48235923592.066.966.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
483107713590.3251.083.7ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
48435903590.0106.2106.2Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
48535873587.0124.9124.9Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
48635863586.0139.0139.0Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
48735773577.091.691.6Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
48871533576.5137.668.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
48935643564.0132.7132.7Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
49035633563.076.276.2Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
49171263563.0208.1104.0The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
49235623562.085.485.4The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49335533553.099.199.1Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
49470913545.5408.9204.4The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
49535453545.085.785.7The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
49635383538.0121.6121.6Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
49770723536.0144.972.5A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
498106073535.7250.983.6Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
49970653532.5197.398.7Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
50035253525.057.057.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
501175813516.2494.098.8Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
50235143514.052.352.3The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WOESSNERArch Biochem Biophys196113786180Yes
50335103510.094.394.3Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
50470093504.5132.566.2The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
505385473504.3786.171.5Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
50635003500.087.487.4Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
50734933493.0108.9108.9Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
508174403488.0609.6121.9Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, BMJ200919622551No
50934853485.058.958.9Statistical estimations in enzyme kinetics. G N WILKINSONBiochem J196113785321Yes
51034783478.076.876.8Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
51169493474.5207.8103.9Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51234713471.079.979.9The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
51334643464.094.894.8Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
51469243462.0160.480.2Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
51569163458.0182.891.4Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
51669113455.5182.291.1Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
51734553455.069.269.2Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
518103443448.01012.6337.5MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
51934463446.082.182.1Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
52034453445.077.077.0Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
52134443444.0136.8136.8Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
52268823441.0142.771.3Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
52368773438.5162.281.1"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
52434363436.065.365.3The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
52534333433.082.182.1Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
52668623431.0171.485.7TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
52734223422.00.00.0Some factors in the interpretation of protein denaturation. W KAUZMANNAdv Protein Chem195914404936Yes
52834213421.091.391.3Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
52968333416.5171.585.8The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
53034083408.069.969.9Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53134043404.0151.1151.1Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
53267893394.5211.7105.8Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
53367853392.5189.294.6Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
534271173389.6576.072.0The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
53567793389.5203.8101.9Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
53633863386.068.768.7Protein folding and misfolding. Christopher M DobsonNature200314685248No
537101553385.098.232.7The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C GREENWOOD, W M HUNTER, J S GLOVERBiochem J196314097352Yes
538101333377.7275.091.7GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hanzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
53967533376.5223.1111.5Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
540135023375.5761.3190.3Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
54133743374.0113.0113.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
54233683368.076.676.6Photoelectrochemical cells. M GratzelNature200111713540Yes
54333653365.068.568.5The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
54467133356.5217.4108.7Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54567083354.0160.480.2In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
546100383346.0277.092.3Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
54766873343.5271.4135.7GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
54866803340.0582.2291.1Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
54933383338.060.160.1Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
55033363336.067.967.9Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
55133333333.0100.0100.0Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
55266623331.056.928.4The serial cultivation of human diploid cell strains. L HAYFLICK, P S MOORHEADExp Cell Res196113905658Yes
55333313331.0106.7106.7What is value in health care? Michael E PorterN Engl J Med201021142528Yes
55466623331.0184.392.2mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
55533233323.087.987.9ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
55666193309.5103.051.5Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
55733063306.094.894.8Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
55833053305.083.683.6Gene regulation by steroid hormones. M BeatoCell19892644044No
55932993299.046.246.2Equilibrium Ultracentrifugation Of Dilute Solutions. D A YPHANTISBiochemistry196414155091Yes
56032853285.077.877.8Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
56132833283.064.064.0STATs and gene regulation. J E DarnellScience19979287210No
56298453281.7471.2157.1Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
56332813281.069.569.5Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
564131163279.0489.3122.3APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
56598363278.7275.491.8FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
56632783278.074.574.5Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
56765503275.0161.981.0Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
56832713271.0110.9110.9The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
56932693269.051.151.1A Rationale And Test For The Number Of Factors In Factor Analysis. J L HORNPsychometrika196514306381Yes
57065313265.5161.880.9Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
57197943264.7181.260.4Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
57232603260.0125.6125.6Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
57332563256.074.674.6The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57432543254.066.066.0CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
57532533253.066.666.6TGFbeta in Cancer. Joan MassagueCell200818662538No
576130003250.0298.174.5Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
57732453245.093.093.0Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
57864833241.5133.566.8Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
57932303230.066.066.0Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
58032273227.070.370.3Calcium signaling. David E ClaphamCell200718083096No
58132223222.059.059.0Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
58232213221.0155.5155.5Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
58332163216.027.427.4Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LYONNature196113764598Yes
58432123212.086.386.3Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
58532063206.0173.3173.3Obesity: global epidemiology and pathogenesis. Matthias BluherNat Rev Endocrinol201930814686No
58696173205.7405.1135.0Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
58732053205.066.366.3Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
58832043204.0142.6142.6The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
58932023202.099.099.0Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
59063933196.5109.955.0The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
59131903190.0109.4109.4Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
59231863186.073.573.5Obesity as a medical problem. P G KopelmanNature200010766250No
59331833183.086.386.3Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
59495323177.3193.664.5Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
595127093177.2359.489.8Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
59631763176.0126.5126.5Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
59763523176.0140.170.0Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
59863443172.0294.2147.1Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
59963353167.5135.467.7MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
60031673167.074.274.2WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
60131673167.093.893.8The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
60231643164.077.777.7The transforming growth factor-beta family. J MassagueAnnu Rev Cell Biol19902177343No
60331643164.070.670.6T cell exhaustion. E John WherryNat Immunol201121739672No
60431573157.0105.2105.2Measurement of pain. E C HuskissonLancet19744139420Yes
60531563156.073.173.1MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
60631513151.085.885.8The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
60762923146.0147.974.0Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
60862903145.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S REITMAN, S FRANKELAm J Clin Pathol195713458125Yes
60931423142.0155.7155.7Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
61062843142.0161.680.8Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
61131413141.00.00.0Diffusion-in-gel methods for immunological analysis. O OUCHTERLONYProg Allergy195813578996Yes
61231393139.068.468.4Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61362743137.0130.865.4Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
61493603120.0311.1103.7Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
61531183118.073.473.4Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
61631183118.0165.0165.0High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
61731083108.094.594.5A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
61831013101.0103.8103.8The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
61930993099.093.093.0Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
620185893098.2885.4147.6DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
62192573085.7296.798.9Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
62292483082.7213.271.1The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
623123223080.5283.770.9Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
62461573078.5125.662.8Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62592293076.3230.977.0Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
62692283076.0203.867.9TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
62730693069.059.659.6Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
62830663066.084.784.7Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
62930663066.0111.9111.9Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
63030603060.070.070.0Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
63130603060.047.547.5A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HAKOMORIJ Biochem196414135466Yes
63230443044.094.994.9An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
63330413041.055.155.1RNA interference. Gregory J HannonNature200212110901No
63430413041.030.130.1Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MITCHELLNature196113771349Yes
63560793039.5191.395.7Extracellular vesicles: exosomes, microvesicles, and friends. Graca Raposo, Willem StoorvogelJ Cell Biol201323420871No
63630383038.071.171.1Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
63760703035.0187.393.7Tissue engineering. R Langer, J P VacantiScience19938493529No
63890983032.7175.358.4Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
63960653032.5144.172.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
64030243024.091.791.7The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
64130223022.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SELDINGERActa Radiol (Stockh)195313057644Yes
64260403020.0235.3117.7Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
64330203020.073.773.7Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
64430183018.088.788.7SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
64530173017.00.00.0The genetical structure of populations. S WRIGHTAnn Eugen195124540312Yes
64630113011.056.856.8Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64730113011.065.965.9Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
64830113011.00.00.0A study of fixation for electron microscopy. G E PALADEJ Exp Med195214927794Yes
64930013001.0128.0128.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
65029942994.070.370.3Structure and function of telomeres. E H BlackburnNature19911708110No
65129892989.068.068.0Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
65229882988.056.656.6Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65359622981.0124.962.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
65429802980.091.191.1Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
65529782978.057.357.3Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65629752975.051.851.8The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
65759472973.5180.290.1The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
65829622962.074.574.5Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
65929622962.061.461.4Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
66029622962.0125.9125.9Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
66188842961.3194.764.9Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
66288652955.0241.580.5Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
66359082954.0176.888.4Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66458972948.5194.097.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
66529472947.044.344.3Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
66629472947.061.961.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
66729402940.082.682.6Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
66829392939.0130.9130.9The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
66958752937.5198.599.2The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
67058732936.5125.562.8Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
67129362936.060.460.4Principles of CDK regulation. D O MorganNature19957877684No
67229342934.057.657.6A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
67329342934.072.672.6The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67429292929.091.191.1Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
67529262926.052.552.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
67658402920.0169.284.6Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
67729192919.086.686.6Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
67829172917.075.975.9The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
67958292914.5130.365.2Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
68029142914.073.473.4Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68187362912.00.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J HAVEL, H A EDER, J H BRAGDONJ Clin Invest195513252080Yes
68258212910.5161.580.8Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
68329102910.070.770.7Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
68429082908.048.748.7Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
685174452907.5376.162.7Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
68629072907.086.986.9Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
68757992899.5249.4124.7Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
68828962896.095.395.3Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
68928962896.068.268.2Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
69057912895.5163.481.7Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
69128942894.00.00.0Notes on sugar determination. M SMOGYIJ Biol Chem195214938350Yes
69257772888.5154.277.1Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69328872887.048.948.9A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GEHANBiometrika196514341275Yes
69457672883.5115.257.6Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
69528832883.0128.3128.3Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
69628782878.083.283.2Separation of leukocytes from blood and bone marrow. Introduction. A BoyumScand J Clin Lab Invest Suppl19685707208Yes
69728732873.060.660.6Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
69828732873.076.976.9Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
69957452872.5194.697.3A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
70028722872.050.650.6One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
70157312865.5111.155.5Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
70228612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SCHNEIDERJ Biol Chem194521005736Yes
70357212860.5172.586.2Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
70428562856.072.172.1Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
70585542851.3246.882.3Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
70628442844.00.00.0A study of the adrenotropic receptors. R P AHLQUISTAm J Physiol194818882199Yes
70728402840.092.992.9A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
70828392839.096.596.5Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
70928382838.092.692.6Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
71056662833.0203.1101.5Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
71156562828.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D WATSON, F H CRICKNature195313054692Yes
71228252825.082.882.8Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
71356482824.0158.979.5Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
71428212821.0110.6110.6A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
71556412820.5172.586.2Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
71656402820.0146.273.1Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
71728172817.063.863.8Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71884502816.7221.974.0Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
71928152815.0110.5110.5What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
72056282814.0134.167.0Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
72128132813.065.365.3Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
72228112811.063.863.8Memory--a century of consolidation. J L McGaughScience200010634773No
72356142807.0132.266.1Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
72456142807.0125.662.8Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
72556102805.0152.076.0The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
72628002800.056.256.2Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
72756002800.0314.8157.4A modified uronic acid carbazole reaction. T BITTER, H M MUIRAnal Biochem196213971270Yes
72855942797.0134.367.2Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
72927952795.068.268.2Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
730111762794.0321.780.4Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
73127932793.0111.7111.7Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
73255802790.077.838.9A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G MARTIN, B N AMESJ Biol Chem196113767412Yes
73327882788.052.852.8The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
73427882788.064.764.7An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
73527872787.061.961.9Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
73627852785.087.887.8Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
737111342783.5293.073.2Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
73827812781.024.124.1Satellite cell of skeletal muscle fibers. A MAUROJ Biophys Biochem Cytol196113768451Yes
73955572778.5167.283.6Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
74055552777.5177.388.7The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
74127772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
742110822770.5320.680.2Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
74355402770.0159.679.8The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
74427692769.061.161.1Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
74527682768.061.661.6Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
74627672767.060.560.5Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
74727652765.060.160.1On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
748110512762.8258.464.6Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
74982802760.0211.370.4Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
75027602760.066.066.0A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
75127592759.064.764.7P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
75227552755.065.765.7Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
75327542754.074.974.9Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
75427522752.0144.5144.5Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
75527512751.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SVENNERHOLMBiochim Biophys Acta195713436486Yes
75682422747.3206.268.7Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
75727442744.081.881.8Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
75827432743.097.597.5Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
75982272742.3329.0109.7Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
76054832741.5109.054.5Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J SILNESS, H LOEActa Odontol Scand196414158464Yes
76154782739.0107.753.9High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
76254692734.5215.6107.8A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
76327302730.0107.3107.3Metazoan MicroRNAs. David P BartelCell201829570994No
76427252725.067.467.4Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
76554502725.0109.554.8MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
76681502716.7174.558.2Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
76727142714.069.469.4Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
76827092709.073.773.7Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
76954172708.5102.751.4Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
77054142707.0123.161.5A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
771108182704.5226.356.6Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
77281132704.3194.264.7RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
77354062703.0136.268.1UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
77454052702.5118.559.2Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
77527022702.054.954.9Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
77627012701.0107.6107.6Deep learning in neural networks: an overview. Jurgen SchmidhuberNeural Netw201525462637No
77727002700.056.456.4Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
77853982699.0232.6116.3Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
77926992699.082.882.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
78026972697.057.957.9The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
78153922696.0141.270.6Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
78226952695.051.251.2Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
78326952695.049.749.7Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
78426902690.050.650.6Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
78580672689.0234.178.0Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
78626852685.099.499.4Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
78726812681.074.274.2Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
78880332677.7194.965.0MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
78926762676.063.763.7Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
79053492674.5130.165.0A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
79153412670.5172.086.0The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
79226692669.061.561.5Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
79353302665.0154.877.4SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
79453302665.0130.465.2ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
79553292664.572.136.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
79626602660.059.259.2Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
79726592659.077.077.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
79826582658.065.965.9The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
79926582658.072.972.9Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
80026552655.070.070.0Dominant forces in protein folding. K A DillBiochemistry19902207096No
80126492649.0106.2106.2The biology of oxygen radicals. I FridovichScience1978210504Yes
80226492649.065.465.4A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
80326472647.055.455.4Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
80426452645.064.164.1MYC on the path to cancer. Chi V DangCell201222464321No
80526442644.080.580.5Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
80652862643.0147.873.9Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
80726422642.055.355.3Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
808422252639.11285.880.4Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
80979152638.3397.2132.4SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
81052762638.0110.455.2Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
81126372637.093.993.9UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
812105402635.0263.165.8GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
81352552627.5126.463.2The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
81478802626.7316.6105.5Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
81552452622.5116.658.3Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
81652342617.00.00.0Some quantitative uses of drug antagonists. O ARUNLAKSHANA, H O SCHILDBr J Pharmacol Chemother195913651579Yes
81752312615.5160.580.2The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
81852242612.0179.990.0A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
81926112611.086.186.1Working memory. A BaddeleyScience19921736359No
82026112611.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
82152192609.5169.384.7Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
82226062606.035.535.5The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
82352122606.0164.682.3PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
82425982598.055.155.1G1 phase progression: cycling on cue. C J SherrCell19947954821No
82525982598.0115.3115.3Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82625972597.080.580.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
82725932593.056.356.3The inflammatory reflex. Kevin J TraceyNature200212490958No
82851822591.0101.951.0Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
82951742587.0111.555.8Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
83025862586.075.275.2PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
83177382579.3215.171.7Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
83225792579.0106.6106.6The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
83325772577.073.173.1Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
83425762576.061.361.3Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
83525762576.069.869.8Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
83625712571.0120.2120.2The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
83725702570.080.980.9Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
83825702570.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PORTERBiochem J195914434282Yes
83925592559.061.161.1Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
84051152557.5218.5109.2The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
84151142557.0276.4138.2A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
84225552555.0164.7164.7User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
84351092554.5138.769.3The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
84425542554.0103.6103.6The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
84525512551.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SMITHIESBiochem J195513276348Yes
84625502550.0125.9125.9The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BOYDENJ Exp Med196213872176Yes
84725492549.070.970.9Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
84825472547.050.850.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
84925472547.074.774.7Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
85050912545.5147.473.7Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
85150872543.5149.174.5Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
85250712535.5143.271.6Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
85350692534.5121.560.8Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
85425342534.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FITTSJ Exp Psychol195413174710Yes
85575982532.7198.766.2trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni GabaldonBioinformatics200919505945Yes
85625322532.067.167.1TGFβ signalling in context. Joan MassagueNat Rev Mol Cell Biol201222992590No
85725312531.076.376.3A two process model of sleep regulation. A A BorbelyHum Neurobiol19827185792Yes
85825302530.068.168.1Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
859101032525.8213.353.3MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
86050462523.070.835.4Periodontal Disease In Pregnancy. I. Prevalence And Severity. H LOE, J SILNESSActa Odontol Scand196314121956Yes
86125232523.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
86225202520.0130.7130.7The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
86325192519.044.244.2Wnt signaling and cancer. P PolakisGenes Dev200010921899No
86425182518.076.976.9Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
86550362518.0132.566.2Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86650292514.596.148.0CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
86750252512.5148.874.4Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
86825112511.079.779.7Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
86925082508.082.482.4Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
87050152507.5130.665.3Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
87125012501.057.057.0Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
87249922496.0129.864.9Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
87349862493.0161.480.7Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
87449852492.5180.690.3Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
87524912491.050.650.6Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
87624882488.069.869.8Hazards of heavy metal contamination. Lars JarupBr Med Bull200314757716No
87749742487.0161.580.8Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rossello-MoraProc Natl Acad Sci U S A200919855009Yes
87824852485.044.244.2Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
87924852485.062.462.4Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
88024832483.060.960.9The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
88124802480.052.252.2A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
88224762476.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LENNOXVirology195513267987Yes
88324752475.0111.8111.8Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
88424752475.062.562.5Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
88549492474.593.646.8The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
88624732473.076.576.5Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
88724712471.095.195.1Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
88824712471.052.352.3Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
88924712471.043.743.7Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
89049272463.594.947.5Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
891123122462.4278.155.6Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
89224622462.059.559.5Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
89349242462.0118.459.2Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
89473832461.0156.252.1The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
89524592459.047.347.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
89624582458.053.253.2Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
89749112455.5105.052.5AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
89849102455.0120.960.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
89924552455.070.170.1Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
90098062451.5210.252.5Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
90124512451.0129.7129.7Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
90224502450.028.128.1Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HIGUCHIJ Pharm Sci196314088963Yes
90349002450.0131.665.8Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
90424492449.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BERTANIJ Bacteriol195114888646Yes
90524482448.065.065.0Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
90624472447.058.658.6Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
90797862446.5193.948.5WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
90824452445.053.853.8Social controls on cell survival and cell death. M C RaffNature19921557121No
90924432443.078.678.6Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
91048602430.0105.452.7Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
91124302430.0128.3128.3Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
91224292429.064.064.0Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
91324282428.061.861.8Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
91424282428.059.359.3The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
91524262426.061.961.9The importance of selenium to human health. M P RaymanLancet200010963212No
91624252425.067.667.6Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
91748432421.5174.987.5Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
91824172417.054.754.7A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
91924172417.051.951.9Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
92024172417.00.00.0Muscle structure and theories of contraction. A F HUXLEYProg Biophys Biophys Chem195713485191Yes
92124152415.074.074.0Human error: models and management. J ReasonBMJ200010720363Yes
92224152415.057.457.4The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
92372432414.3220.773.6Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
92424142414.062.262.2Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
92548282414.0108.954.5Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
92624122412.049.149.1Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
92748202410.0111.855.9Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
92848182409.0126.063.0A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
92924082408.062.762.7A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
93024062406.055.655.6Specification of cerebral cortical areas. P RakicScience19883291116No
93148102405.0135.367.7Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
93224042404.049.549.5NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
93348072403.597.248.6New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
93424022402.080.280.2Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JobsisScience1977929199Yes
93548022401.090.945.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassagueCell200312809600No
93647972398.5174.787.3The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
93771802393.369.323.1On The Nature Of Allosteric Transitions: A Plausible Model. J MONOD, J WYMAN, J P CHANGEUXJ Mol Biol196514343300Yes
93847862393.0133.866.9Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
93947842392.0124.562.2Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
94047822391.0118.059.0Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
94123832383.074.174.1Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
94223822382.056.056.0Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
94323812381.0126.6126.6The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
94495092377.2444.3111.1The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
94523752375.098.098.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
94647492374.5103.051.5Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
94723722372.0137.8137.8Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
94847442372.088.844.4A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
94947342367.0118.459.2Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
95023662366.078.878.8A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
95123662366.047.647.6The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
95270962365.3192.364.1Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
95347292364.5168.384.2Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
954189142364.2730.791.3The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver GlocknerNucleic Acids Res201323193283Yes
95547262363.096.248.1Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
95670872362.3202.467.5The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
95770782359.3281.093.7The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
95823512351.057.757.7A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
95923512351.040.040.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
96023492349.045.445.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
96123472347.051.751.7The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
96223452345.091.091.0Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
96346892344.577.338.6On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
96446872343.5136.768.3Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
96593662341.5216.154.0Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
96623412341.065.665.6Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
96723402340.042.642.6Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96846762338.087.843.9The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
96923382338.056.056.0The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
97046712335.5102.251.1Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
97123322332.084.084.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
97223312331.042.942.9Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
97323302330.068.968.9Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
97446552327.5114.857.4A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
97546542327.0115.457.7The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
97623242324.071.871.8Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
97723232323.064.564.5Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
97869622320.7204.868.3Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
97923202320.071.671.6Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
98046372318.5128.264.1Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
98146302315.0116.658.3The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
98223142314.052.052.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
98323122312.085.685.6Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
98446242312.0190.595.2The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
98523122312.049.749.7Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
98623112311.061.761.7The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
98746172308.5109.854.9Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
98823082308.056.156.1Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
98946122306.076.338.1Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99023062306.056.756.7RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
99146052302.569.134.5High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
99223022302.056.656.6Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
99345972298.590.745.4Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
99422982298.048.148.1Theta oscillations in the hippocampus. Gyorgy BuzsakiNeuron200211832222No
99545952297.5151.375.7Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
99668852295.0138.146.0EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
99768822294.0264.888.3Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
99822942294.090.290.2Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
99945852292.5109.254.6Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
100022892289.049.449.4A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
100122842284.045.245.2SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
100222832283.075.875.8Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
100322832283.069.069.0Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
100422792279.091.591.5Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
100545562278.0188.894.4The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
100622772277.047.447.4Complement. First of two parts. M J WalportN Engl J Med200111287977No
100722762276.065.465.4Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
100822752275.068.468.4Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
100922752275.068.468.4A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
101045492274.5110.255.1Building better batteries. M Armand, J-M TarasconNature200818256660No
101122732273.060.760.7Hybrid porous solids: past, present, future. Gerard FereyChem Soc Rev200818197340Yes
101222722272.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A CLAUSSActa Haematol195713434757Yes
101322692269.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PENNESJ Appl Physiol194818887578Yes
101422682268.054.854.8Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
101545322266.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B SCOVILLE, B MILNERJ Neurol Neurosurg Psychiatry195713406589Yes
101622652265.056.356.3Descending control of pain. Mark J MillanProg Neurobiol200212034378No
101745302265.083.942.0SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
101867942264.7155.451.8APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
101922642264.053.953.9Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
102045262263.089.244.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
102145252262.5163.281.6mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
102222612261.060.260.2Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
102322592259.0138.5138.5Application of a microtechnique to viral serological investigations. J L SEVERJ Immunol196213910995Yes
102422572257.066.266.2Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
102522572257.050.050.0Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
102645132256.586.343.1Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
102745102255.0141.870.9Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
102822552255.051.351.3Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
102922552255.056.256.2What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
103045062253.039.119.6A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
103122522252.053.053.0Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
103222502250.048.148.1Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
103344982249.0102.451.2A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
103422492249.061.461.4Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
103544982249.0128.564.2Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
103667462248.7241.380.4Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
103767442248.0211.370.4Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris Sherman, Hepatology201121374666No
103822462246.060.960.9Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
103922462246.0116.0116.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
104022462246.054.854.8Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
104144922246.0121.060.5Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
104222462246.099.199.1International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
104344912245.5160.180.0ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
1044246632242.1594.254.0PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
104522422242.057.657.6The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
104622422242.076.776.7Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
104722412241.052.652.6Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
104844822241.0102.851.4Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
104944802240.0126.963.5Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
105022392239.048.648.6Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
105122382238.048.148.1Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
105222372237.049.049.0The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
105322342234.065.665.6Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
105444642232.098.949.5The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
105522312231.073.273.2Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
105622302230.0111.5111.5Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
1057133742229.0295.449.2NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
105822292229.052.252.2Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
105922282228.076.376.3Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
106022272227.095.295.2The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
106122272227.052.252.2Mechanisms and genes of cellular suicide. H StellerScience19957878463No
106244522226.0139.469.7A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
106322262226.0110.1110.1Subjective well-being. E DienerPsychol Bull19846399758No
106444492224.598.049.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
106522242224.062.662.6Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
106644412220.5195.998.0Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
106722152215.044.944.9Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
106822132213.064.164.1Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
106922122212.072.072.0A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
107022112211.091.591.5A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
107144222211.0238.0119.0OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
107222092209.067.567.5Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
107322072207.039.639.6NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
107422052205.056.456.4Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
107522052205.082.882.8Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
107622042204.048.348.3Chemokines. B J RollinsBlood19979242519No
107722032203.078.978.9Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
107888022200.5281.970.5Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
107922002200.076.576.5International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
108043992199.583.441.7Network biology: understanding the cell's functional organization. Albert-Laszlo Barabasi, Zoltan N OltvaiNat Rev Genet200414735121No
108121982198.053.553.5Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gokhan S HotamisligilCell201020303879No
108287912197.8340.385.1jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramon Doallo, David PosadaNat Methods201222847109Yes
108343932196.593.746.9Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
108443922196.094.347.1Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
108543892194.593.146.5The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
108665712190.3165.955.3GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
108765672189.0188.562.8Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
108843782189.0121.860.9Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
108965662188.7178.359.4Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdottir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
109021882188.058.958.9Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
109143732186.5147.373.7Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
109243682184.080.440.2The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
109321812181.051.251.2Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
109465422180.7118.539.5Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
109521802180.048.648.6Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
109643572178.5152.676.3ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
109721762176.077.877.8Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
109821742174.058.958.9Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
109921742174.046.246.2Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
110043352167.5131.966.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
110121672167.064.864.8The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
110286662166.5281.070.2Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
110321662166.041.541.5Protein modules and signalling networks. T PawsonNature19957531822No
110421652165.084.984.9Perception of risk. P SlovicScience19873563507Yes
110521652165.060.260.2phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
110621632163.051.551.5Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
110743252162.5102.851.4Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
110843252162.5117.558.8Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
110921602160.049.649.6Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
111021602160.050.850.8Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
111143142157.0101.050.5Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
111221572157.092.992.9Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
111343102155.0189.594.8Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
111443062153.082.141.0Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
111521532153.030.530.5Sedimentation Studies Of The Size And Shape Of Dna. F W STUDIERJ Mol Biol196514290352Yes
111643002150.0115.557.8EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
111742972148.5106.753.4Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
111842972148.594.147.0Liver fibrosis. Ramon Bataller, David A BrennerJ Clin Invest200515690074No
111985932148.2200.150.0Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
112021482148.042.642.6Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
112121482148.067.067.0The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
112221472147.042.442.4Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
112321472147.00.00.0On respiratory impairment in cancer cells. O WARBURGScience195613351639Yes
112421462146.00.00.0A new specific color reaction of hexuronic acids. Z DISCHEJ Biol Chem194720281638Yes
112564362145.3129.043.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
112621452145.041.341.3Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
112721442144.058.658.6Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
112821442144.049.749.7Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
112942862143.071.035.5A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H VENABLE, R COGGESHALLJ Cell Biol196514287192Yes
113021432143.066.066.0Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
113121422142.067.667.6The Gingival Index, the Plaque Index and the Retention Index Systems. H LoeJ Periodontol19675237684Yes
113264262142.0145.948.6MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WuthrichJ Mol Graph19968744573Yes
113385682142.0203.250.8Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
113442842142.0164.082.0Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
113521412141.040.540.5Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
113642792139.5104.152.0Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
113742762138.0121.860.9Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
113821382138.064.764.7Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
113942762138.0169.484.7The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
114042742137.097.848.9Neuronal oscillations in cortical networks. Gyorgy Buzsaki, Andreas DraguhnScience200415218136No
114164102136.7267.889.3Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
114242722136.0181.991.0The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
114321362136.064.264.2The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
114464082136.0204.168.0Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
114542682134.036.218.1Genetic regulatory mechanisms in the synthesis of proteins. F JACOB, J MONODJ Mol Biol196113718526Yes
114621342134.068.968.9Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
114742622131.0110.555.2The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
114821292129.041.841.8Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
114921282128.054.554.5Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
115042552127.5121.760.9Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
115121252125.044.144.1Mammalian G1 cyclins. C J SherrCell19938513492No
115242472123.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F BEERS, I W SIZERJ Biol Chem195214938361Yes
1153169862123.2476.359.5The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
115421232123.043.743.7Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
115521232123.040.940.9DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
115684902122.5314.478.6The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerstromBr J Addict19911932883Yes
115742402120.082.541.2Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
115821202120.035.135.1Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AMINOFFBiochem J196113860975Yes
115921202120.058.358.3Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
116021182118.042.842.8Molecular bases for circadian clocks. J C DunlapCell19999988221No
116142362118.0122.861.4Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
116221152115.083.683.6A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
116321152115.050.250.2Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
116463402113.3205.168.4Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
116521122112.060.360.3The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
116642242112.0158.579.2Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
116721112111.044.544.5Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
116863312110.3203.067.7Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
116942202110.082.241.1Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
117021092109.049.349.3Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
117121092109.065.465.4Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
117242162108.0106.053.0Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
1173105372107.4328.665.7The hallmarks of aging. Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
1174147512107.3319.245.6Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
117563222107.3182.961.0Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
117621032103.098.798.7Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
117762892096.3204.968.3Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
117820932093.047.247.2DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
117920932093.080.280.2Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
118041862093.0228.7114.3ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
118141852092.580.340.1The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
118220922092.064.664.6Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
118341822091.083.741.9'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
118441802090.0116.958.5Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
118520902090.040.440.4DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
118620902090.047.047.0The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
118741802090.0132.766.3Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
118820892089.040.140.1Method For Assay Of Intestinal Disaccharidases. A DAHLQVISTAnal Biochem196414106916Yes
118983512087.8267.867.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
119041692084.5150.075.0The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
119141692084.5284.7142.3WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
119220832083.052.552.5The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
119320832083.056.656.6Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
119420832083.050.250.2Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
119520822082.039.539.5Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
1196145732081.9321.345.9Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
119741632081.5118.759.4Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
119820812081.074.074.0Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
119920802080.040.140.1Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
120020802080.059.359.3ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
120120802080.042.442.4TRP channels as cellular sensors. David E ClaphamNature200314654832No
120241602080.0154.577.2Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
120341582079.099.349.6Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
1204166182077.2391.348.9Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
120520762076.048.748.7Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
120641512075.5110.755.4New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
1207145162073.7413.059.0AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
120820722072.036.336.3Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SKOUPhysiol Rev196514337569No
120920722072.038.538.5Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
121020702070.039.039.0CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
121120692069.042.342.3G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
121241352067.5229.0114.5Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
121320662066.064.564.5Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
121420662066.043.043.0The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
121520662066.072.672.6Selenium and human health. Margaret P RaymanLancet201222381456No
121641302065.0140.070.0The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
121720642064.077.777.7Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
121841252062.5146.473.2Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
121941232061.585.542.8A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
122020612061.046.846.8Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
122141212060.595.747.9Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
122241212060.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R DULBECCO, M VOGTJ Exp Med195413130792Yes
122320602060.018.618.6The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W CLELANDBiochim Biophys Acta196314021667Yes
122441202060.0176.988.5A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
122520592059.063.363.3Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
122620582058.051.651.6Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
122761742058.0229.076.3Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
122861712057.0197.365.8AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
122920572057.00.00.0Cognitive maps in rats and men. E C TOLMANPsychol Rev194818870876Yes
123020542054.047.447.4Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
123120532053.084.284.2A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
123220532053.023.823.8Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LITTLEFIELDScience196414168277Yes
123320522052.065.165.1Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
123420502050.051.351.3From sensation to cognition. M M MesulamBrain19989648540No
123541002050.0144.072.0The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
123620482048.034.634.6ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
123720482048.0100.6100.6Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NEELAm J Hum Genet196213937884Yes
123820462046.056.456.4Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
123920462046.045.945.9Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
124040912045.5138.169.0The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683Yes
124120442044.067.367.3The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
124220432043.058.758.7Protein oxidation and aging. E R StadtmanScience19921355616No
124340852042.588.444.2Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
124440732036.5109.754.9Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
124540712035.5125.062.5Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
124640712035.5109.654.8Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
124720352035.070.270.2Purinergic nerves. G BurnstockPharmacol Rev19724404211No
124820352035.034.634.6Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
124920352035.046.246.2The genetics of ageing. Cynthia J KenyonNature201020336132No
125040682034.092.246.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
125140662033.089.945.0The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
125240642032.097.848.9Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
125340632031.586.643.3ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
125420312031.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A SHOLLJ Anat195313117757Yes
1255182752030.6567.263.0The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
125620302030.047.247.2Calcium signaling. D E ClaphamCell19957834745No
125760882029.3205.468.5Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
125840572028.5101.750.9Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
125940572028.599.249.6Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
126040562028.0125.462.7Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
126181082027.0222.255.5Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
126220272027.056.856.8Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
126340532026.5138.669.3Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
126420252025.058.258.2Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
126520242024.036.836.8In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
126620242024.051.751.7Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
126720242024.059.859.8Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
126820232023.052.652.6Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
126920232023.055.155.1Introduction and General Overview of Cyclodextrin Chemistry. Jozsef SzejtliChem Rev199811848947Yes
127020222022.062.762.7Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
127120212021.050.450.4Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
127220202020.052.652.6Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
127340382019.077.939.0A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelieresJ Microsc200617210054Yes
127420182018.090.290.2A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
127520152015.083.683.6The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
127640302015.098.349.1Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
127720142014.00.00.0Antigen-antibody reactions in gels. O OUCHTERLONYActa Pathol Microbiol Scand194918143039Yes
127820132013.038.038.0Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
127920132013.041.541.5The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
128040202010.085.342.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
128120102010.041.141.1XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
128220102010.045.345.3The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
128320102010.038.938.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
128420072007.043.443.4Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
128520072007.042.742.7A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
128620072007.050.450.4Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
128780192004.8186.746.7Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
128820042004.043.743.7Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
128920032003.054.854.8The biology of interleukin-6. T KishimotoBlood19892473791No
129060092003.0107.335.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
129140032001.586.443.2The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
129240002000.0115.557.8LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
129319981998.076.576.5Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
129419981998.034.634.6Signaling--2000 and beyond. T HunterCell200010647936No
129519971997.059.259.2Social relationships and health. Sheldon CohenAm Psychol200415554821No
129619961996.039.739.7Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
129739911995.5121.260.6Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
129819951995.063.463.4Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
129939881994.0107.954.0Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
130019941994.043.443.4Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
130139841992.0156.678.3Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
130219911991.043.843.8The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
130319911991.022.622.6A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
130419911991.052.652.6Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
130519911991.077.777.7Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
130639801990.094.347.1Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
130719901990.040.340.3Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
130819901990.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
130939781989.0101.150.5Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
131019891989.051.251.2What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
131139761988.089.544.8PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schuttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
131239751987.577.138.5An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
131339691984.596.448.2Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
131439691984.590.545.2Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
131539661983.059.529.8Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R MORRISON, L M SMITHJ Lipid Res196414221106Yes
131619821982.051.351.3Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
131779271981.8306.876.7A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
131819811981.039.839.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
131939571978.597.248.6ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
132039551977.5120.960.5Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
132198831976.6224.845.0Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
132219761976.039.139.1The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
132339511975.5114.457.2New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
132439501975.0132.766.3Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
132519751975.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R STEELEAnn N Y Acad Sci195913833973Yes
132659231974.3350.8116.9An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
132719741974.058.758.7The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
132859221974.0150.050.0Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
132919721972.058.758.7The inverse care law. J T HartLancet19714100731Yes
133039441972.0136.468.2The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
133139441972.094.547.2The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
1332118301971.7337.156.2Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
133339411970.5110.355.1The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
133419691969.015.915.9Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
133519691969.038.838.8Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
133619691969.048.548.5High-speed scanning in human memory. S SternbergScience19665939936Yes
133739371968.5115.757.9The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
133819681968.050.650.6The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
133919681968.070.370.3AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
134059021967.3246.182.0Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graca RaposoNat Rev Mol Cell Biol201829339798No
134119671967.057.657.6Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
134239321966.0125.963.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
134319661966.070.470.4Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
134439321966.0122.161.0Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
134519661966.00.00.0On estimating the relation between blood group and disease. B WOOLFAnn Hum Genet195514388528Yes
134619661966.073.373.3α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
1347137601965.7366.952.4BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
134819651965.041.341.3Exploring complex networks. S H StrogatzNature200111258382No
1349117871964.5336.756.1New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
135019641964.051.851.8The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
135158921964.0170.056.7Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
135258911963.7193.664.5Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
135319631963.066.566.5Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
135419621962.055.255.2The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
135519611961.044.744.7The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
135639221961.0101.850.9Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
135719601960.055.755.7Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
135839201960.0105.852.9The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
135958791959.7148.049.3Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
136039181959.073.436.7Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
136139181959.079.839.9Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
136239141957.085.943.0Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
136319561956.057.457.4Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
1364117331955.5267.544.6GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
136519541954.063.363.3Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
136619541954.045.745.7Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
136719521952.041.141.1The etiology of chondromalacia patellae. R E OUTERBRIDGEJ Bone Joint Surg Br196114038135Yes
136819501950.047.847.8Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
136938981949.065.532.8Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
137019481948.077.977.9Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
137119471947.042.442.4Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
137219461946.055.455.4Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
137358381946.0257.585.8Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
137419451945.042.642.6Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
137519451945.054.254.2Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
137619451945.042.042.0Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
137719441944.063.863.8The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
137819441944.055.155.1Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
137977751943.8259.965.0Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
138019431943.070.470.4Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
138119431943.051.551.5Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
138258281942.7119.439.8Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
138319421942.045.745.7Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
138419421942.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BOYDENJ Exp Med195114803635Yes
138538831941.569.234.6Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
138619411941.050.350.3Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
138719411941.061.661.6The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
138838791939.584.442.2Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
138919391939.033.733.7The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
139019381938.063.863.8Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
139119381938.045.645.6The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
139238761938.076.338.1A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
139338751937.579.940.0Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
139438731936.5139.769.8Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
139577381934.5322.380.6An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
139638681934.0102.651.3Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
139719341934.040.940.9Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
139819341934.069.069.0The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
139938651932.5102.651.3Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
1400135251932.1473.167.6Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
140119321932.061.661.6Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
140219311931.056.456.4Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
140319301930.046.746.7Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
140419291929.050.250.2DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
140538581929.087.743.9Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
140677101927.5187.446.9p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
140719271927.075.175.1Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
140838541927.086.743.4The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
140919261926.041.441.4Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
141019251925.063.963.9Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
141119241924.053.253.2Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
141219231923.051.451.4Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141319221922.061.461.4Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
141438421921.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J VOGEL, D M BONNERJ Biol Chem195613278318Yes
141519191919.039.839.8A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
141619191919.046.746.7DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
141719191919.057.257.2The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
141857531917.7125.041.7Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
141957501916.7151.150.4Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RohlMol Biol Evol199910331250Yes
142038281914.0170.085.0Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
142138271913.5123.861.9miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
142219131913.046.446.4Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
142319121912.039.739.7The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
142419101910.050.850.8Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
142538191909.5127.263.6Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
142619091909.053.553.5In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
142719091909.072.972.9Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
142857221907.3337.2112.4Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
142938131906.584.942.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
143019061906.067.867.8Antibiotics in the aquatic environment--a review--part I. Klaus KummererChemosphere200919185900No
143119051905.076.076.0Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
143276151903.8344.086.0Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
143357101903.3168.256.1Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
143419031903.051.251.2A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
143519011901.041.941.9Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
143619011901.041.041.0The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
143757011900.3116.638.9A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
143819001900.00.00.0The oxidation of ribonuclease with performic acid. C H HIRSJ Biol Chem195613319283Yes
143918971897.088.688.6A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
144037921896.0188.894.4Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
144137911895.5101.250.6Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
144256861895.3116.238.7Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
144337901895.088.344.1Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
144437901895.0278.2139.1Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
144518941894.043.543.5Tricine-SDS-PAGE. Hermann SchaggerNat Protoc200617406207Yes
144618941894.055.355.3Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
144737871893.5144.972.5A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
144818931893.050.250.2Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
144918931893.054.454.4Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
145037851892.589.344.6The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
145118921892.082.682.6Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
145275651891.2252.163.0Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
145318911891.037.437.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
145437791889.5119.159.5An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
145518881888.061.361.3Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
145656601886.7124.941.6A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
145737731886.5106.953.5How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
145837691884.585.442.7The Fas death factor. S Nagata, P GolsteinScience19957533326No
1459131901884.3376.553.8The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, Lancet200718064739Yes
146018841884.043.743.7The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
146137661883.076.838.4Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
146218831883.051.151.1Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
146318821882.037.437.4Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
146437611880.5122.561.2Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
1465150421880.2481.660.2GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, BMJ200818436948Yes
146618801880.036.836.8Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
146737591879.577.438.7Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
146818791879.019.619.6Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
146918781878.085.785.7Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
147018781878.064.964.9The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
147118771877.035.135.1Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
147256311877.0283.994.6Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
147375071876.8197.549.4Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
147418761876.058.358.3The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
147518761876.037.237.2Points of control in inflammation. Carl NathanNature200212490957No
147618761876.049.549.5Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
147756261875.3139.546.5Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
147893701874.0331.066.2UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
147974941873.5210.052.5The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
148018731873.044.644.6Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
148118721872.075.675.6Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
148218721872.053.953.9An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
148374841871.0178.844.7Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
148437421871.0113.356.6Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
148518701870.036.136.1MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
148637381869.098.949.5Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
148718671867.033.733.7Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
148818671867.049.749.7The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
148993311866.2211.642.3Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
149018661866.048.448.4Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
149118661866.074.974.9Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
149218651865.070.470.4Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
149318651865.033.633.6Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
149437271863.5120.160.0Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
149518631863.046.046.0The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
149637221861.0103.952.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
149737221861.077.338.6Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
149837211860.575.137.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
149918601860.035.835.8The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
150037201860.0131.765.8Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
1501148741859.2415.752.0Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
150218581858.057.657.6Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
150318581858.052.152.1Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
150437161858.077.738.9Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
150518571857.042.942.9A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
150618571857.047.447.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
150718561856.033.533.5Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
150818561856.057.157.1The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
150992801856.0436.087.2ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
151018551855.038.838.8The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
151137101855.0102.751.4CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
151218541854.045.745.7Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151318541854.066.166.1Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
151437071853.5188.794.3Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
151518531853.017.917.9A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A ROBINSONIEEE Trans Biomed Eng196314121113Yes
151637061853.084.042.0Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
151755561852.0102.834.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
151837021851.099.950.0Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
151918481848.044.044.0Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
152018471847.041.041.0DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
152192351847.0235.847.2Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
152218471847.036.536.5Protein homology detection by HMM-HMM comparison. Johannes SodingBioinformatics200515531603Yes
152373871846.8339.484.8Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
152436901845.052.926.4Immunoassay of insulin with insulin-antibody precipitate. C N HALES, P J RANDLEBiochem J196313952078Yes
152518441844.042.042.0Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
152618441844.037.537.5Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
152718441844.041.741.7The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
152818431843.041.941.9Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
152918431843.042.242.2Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
153018431843.0174.1174.1Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Brent R StockwellCell202235803244No
153155211840.3142.147.4A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
153218401840.050.050.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
153318401840.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SIMPSONJ Neurol Neurosurg Psychiatry195713406590Yes
153418391839.063.063.0The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
1535239051838.8895.968.9Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, Genet Med201525741868No
153636751837.5141.770.8Assays of glutathione peroxidase. L Flohe, W A GunzlerMethods Enzymol19846727659Yes
153718371837.043.143.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
153818371837.041.641.6The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
153936721836.0113.556.8Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
154018361836.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SKOUBiochim Biophys Acta195713412736Yes
154136721836.095.547.8The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
154218351835.067.367.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
154318341834.053.753.7Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
154418341834.045.345.3Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
154518331833.059.459.4The crisis in antibiotic resistance. H C NeuScience19921509257No
154654971832.3121.440.5A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
154718321832.067.467.4Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
154854961832.0120.640.2Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
154936631831.5130.765.3Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
155018311831.060.060.0Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
155118311831.048.548.5New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
155218311831.052.552.5A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
155336611830.592.546.2Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
155473161829.0139.234.8Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
155518281828.042.842.8Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
155618281828.080.080.0Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
155718271827.043.943.9Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
155818271827.046.846.8Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
155918271827.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
156018261826.034.234.2Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
156118251825.054.954.9Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
156218241824.054.354.3Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
156318241824.049.849.8Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
156436471823.594.047.0A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
156536461823.084.542.2Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
156636451822.5132.766.3The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
156736451822.584.242.1Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
156836431821.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T CAMPBELL, D W FISKEPsychol Bull195913634291Yes
156918211821.054.154.1Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
157036411820.5116.458.2Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
157191021820.4218.443.7Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
157254611820.3140.046.7The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
157318201820.088.788.7Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S COHENJ Biol Chem196213880319Yes
157418201820.088.188.1DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
157572771819.2207.651.9Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
157618191819.043.243.2Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
157718181818.040.740.7A revolution in optical manipulation. David G GrierNature200312917694No
157818181818.040.940.9PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
157918171817.036.336.3Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
1580108981816.3290.348.4A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
158118141814.038.238.2Perceptions of epigenetics. Adrian BirdNature200717522671Yes
158218131813.062.962.9A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
158336251812.5105.953.0The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
158418121812.059.159.1Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
158536211810.590.145.0Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
158636181809.074.537.2Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
158718081808.061.761.7Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
158836151807.5134.167.0The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
158918071807.042.942.9The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
159018071807.037.437.4Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
159154181806.0152.050.7Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallieres, C M. MorinSleep Med200111438246Yes
1592180541805.4563.256.3Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
159390231804.695.619.1Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFEJAMA196314044222Yes
159418041804.037.637.6Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
159554111803.7174.458.1A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
159636071803.5105.252.6An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
159736051802.586.143.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
159818001800.00.00.0The measurement of volume changes in human limbs. R J WHITNEYJ Physiol195313085295Yes
159936001800.080.240.1The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
160017981798.019.419.4Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
160117971797.043.443.4Why genes in pieces? W GilbertNature1978622185Yes
160217971797.096.996.9Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
160335941797.0101.550.8Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
160435921796.0103.451.7Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
160517951795.047.147.1THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
160635891794.5138.269.1MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
160735861793.088.644.3The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
160835851792.5162.581.2Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
160917921792.057.257.2Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
161017921792.055.655.6Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
161135841792.0149.975.0Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
161289551791.0325.965.2Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. J B Saunders, O G Aasland, T F Babor, J R de la Fuente, M GrantAddiction19938329970Yes
161371611790.2276.569.116S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
161417901790.035.635.6Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
161517901790.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HESTRINJ Biol Chem194918133390Yes
161617891789.038.738.7The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
161735781789.0126.363.1Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
161817881788.054.454.4Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
161917871787.040.740.7Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
162017871787.038.538.5Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
162117851785.047.247.2Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
162217851785.037.737.7AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
162317841784.058.958.9Serum albumin. T PetersAdv Protein Chem19853904348No
162435631781.5152.176.0A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
162535611780.5226.2113.1A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
162635611780.573.636.8Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
162735601780.088.344.1Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
162817801780.035.935.9An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
162935591779.586.343.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
163017791779.045.645.6Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
163117791779.063.963.9Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287Yes
163271141778.5305.476.3A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
163317781778.058.258.2Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
163417781778.063.163.1Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
163517751775.052.652.6Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
163617741774.039.139.1Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
163717741774.041.241.2Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
163817731773.065.765.7Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
163917731773.052.652.6Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
164017711771.046.546.5Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
164117711771.050.550.5Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
164217711771.042.442.4External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
164317711771.053.753.7Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
164435411770.5165.983.0Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
164535401770.088.444.2Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
164617701770.064.664.6Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
164717701770.063.263.2A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
164817691769.077.377.3The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
164917681768.037.237.2An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
165017671767.058.458.4Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
165117671767.060.660.6Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
165235341767.043.921.9A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
165335331766.568.234.1The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
165435321766.072.736.4Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
165517661766.033.233.2Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
165617661766.048.548.5Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
165735321766.0109.354.6Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
165817641764.021.221.2Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
165917641764.047.147.1G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
166052911763.7119.139.7Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
166152901763.3122.640.9Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck OrntoftCancer Res200415289330Yes
166252901763.3114.138.0An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
166317621762.064.064.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
166417621762.038.838.8ATPase activity of myosin correlated with speed of muscle shortening. M BaranyJ Gen Physiol19674227924Yes
166517621762.033.733.7The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
166652851761.7163.154.4Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
166717611761.040.140.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
166835221761.089.544.8Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
1669193711761.0482.943.9The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
167017611761.094.094.0Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
167135211760.580.540.2Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
167235201760.093.046.5Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
167317601760.063.363.3Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
167487921758.4307.861.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, J Clin Epidemiol200919631508No
167517581758.038.138.1Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
167635151757.5153.076.5A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
167735151757.580.140.0Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
167870271756.8212.353.1The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
167917561756.044.444.4The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
168017561756.038.438.4The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SudhofNature19957791897No
168117551755.00.00.0A personality scale of manifest anxiety. J A TAYLORJ Abnorm Psychol195313052352Yes
168235081754.0224.9112.5The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
168317541754.040.040.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
168417541754.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
168535071753.585.342.6Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
168617531753.048.648.6The in vitro micronucleus technique. M FenechMutat Res200011113469No
1687105171752.8211.535.2Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
168835041752.099.449.7Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
168917511751.053.853.8Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
169017501750.059.359.3The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
169117501750.060.360.3The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
169217501750.046.446.4Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
169370001750.0263.165.8QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
169417491749.074.274.2Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
169517491749.074.474.4Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
169617491749.073.073.0Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
169769931748.2136.034.0Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
169817481748.059.459.4Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
169917471747.041.841.8Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
170034941747.079.639.8Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
170117461746.040.940.9Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
170234921746.093.646.8Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
170317451745.038.338.3In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
170452321744.0111.537.2Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
170517441744.038.738.7Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
170617441744.038.838.8Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
170717441744.00.00.0A new readability yardstick. R FLESCHJ Appl Psychol194818867058Yes
170869701742.5242.360.6FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
170917421742.062.662.6Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
171017421742.059.859.8The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
171134841742.071.435.7The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
171217421742.045.645.6Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
171352251741.7313.6104.5Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
171417411741.036.236.2The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
171517401740.031.631.6Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
171634791739.586.243.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
171717391739.039.139.1Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
171817391739.0155.5155.5COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
171917381738.032.932.9Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
172017381738.017.417.4The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
172134761738.087.743.9Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
172234751737.5111.155.5The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
172317371737.040.040.0Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
1724173621736.2548.354.8The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
172517351735.068.368.3A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
172634701735.068.734.4Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
1727104081734.7286.447.7Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
172817341734.056.056.0Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
172917341734.069.269.2Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
173069361734.0217.454.4SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Soren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
1731208061733.8622.251.9A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, Ann Intern Med200919414839Yes
173217321732.062.262.2Cyclosporine. B D KahanN Engl J Med19892687689No
173334641732.071.535.8A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FluggeAnal Biochem19846731838Yes
173434641732.082.041.0CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
173586591731.8351.970.4BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
173634631731.589.844.9Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
173717311731.00.00.0The general adaptation syndrome and the diseases of adaptation. H SELYEJ Clin Endocrinol Metab194621025115Yes
173834611730.5128.164.0Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
173934611730.596.548.2Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
174034601730.096.848.4Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
174151891729.7111.437.1Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
174217291729.052.352.3A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
174334571728.591.745.9Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
174451841728.0274.591.5Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
174517281728.031.431.4Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
174617271727.059.059.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
174717271727.065.765.7Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
174851761725.3202.367.4The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
174986221724.4389.277.8Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L SalzbergNat Biotechnol201931375807Yes
175017241724.031.331.3How eukaryotic transcriptional activators work. M PtashneNature19883050531No
175134441722.0113.156.5Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
1752154941721.6470.152.2The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
175334431721.574.737.4Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
175451641721.3230.476.8Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
175517211721.073.173.1The micronucleus test. W SchmidMutat Res197548190Yes
175617211721.045.145.1A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
175734421721.070.135.0The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
175817201720.044.244.2Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
175917201720.035.835.8Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
176017201720.033.433.4DNA in a material world. Nadrian C SeemanNature200312540916No
176117191719.037.337.3Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
176217191719.041.041.0Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
176334371718.5131.465.7Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
176417181718.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RANKINScott Med J195713432835Yes
176517171717.065.865.8Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
176651491716.3120.040.0Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
176717161716.041.941.9The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
176817161716.044.244.2Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
176968611715.2143.735.9Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
177034301715.0127.663.83D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
177117131713.030.730.7Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
177217111711.051.851.8Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
177317101710.048.048.0The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
177417101710.078.178.1ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
177534191709.582.441.2The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
177634191709.593.546.8Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
177734161708.049.724.9A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J KARNOVSKY, L ROOTSJ Histochem Cytochem196414187330Yes
177817071707.046.846.8The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
177917071707.00.00.0Notes on continuous stochastic phenomena. P A P MORANBiometrika195015420245Yes
178017051705.057.357.3Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
178134101705.085.142.5The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
178234051702.565.332.6The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
178334051702.577.738.9Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
178434041702.080.640.3Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
178534021701.072.536.2Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
178617001700.073.373.3Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
178717001700.042.742.7The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
178816991699.055.255.2Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
178916981698.083.483.4Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerstromAddict Behav1978735910Yes
179033961698.066.433.2Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
179116981698.051.251.2The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
179233961698.082.141.0Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
179316971697.032.932.9Hox genes in vertebrate development. R KrumlaufCell19947913880No
179416971697.045.545.5Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
179516971697.068.968.9Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
179616961696.069.569.5PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
179733911695.5195.797.8Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
179833911695.5103.151.5Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
179916951695.040.140.1A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
180016951695.055.255.2Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
180116951695.035.235.2Neuronal calcium signaling. M J BerridgeNeuron19989697848No
180216951695.037.837.8Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
180350851695.0129.843.3Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
180450831694.396.932.3T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
180516941694.040.140.1The molecular genetics of cancer. J M BishopScience19873541204No
180616941694.054.354.3A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
180733871693.593.046.5Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
180833861693.078.839.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
180916931693.038.338.3NADPH oxidase: an update. B M BabiorBlood199910029572No
181016931693.037.637.6Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
181116931693.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
181216931693.072.472.4When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
181333851692.569.834.9Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
181416921692.044.944.9Integrins. E RuoslahtiJ Clin Invest19911985087No
181533841692.070.835.4Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
181633831691.5110.555.2Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
181733831691.5112.456.2Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
181816911691.041.141.1Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
181933821691.075.237.6Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
182016901690.031.131.1Switching and signaling at the telomere. E H BlackburnCell200111572773No
182116901690.029.229.2Plastic Embedding Mixtures For Use In Electron Microscopy. H H MOLLENHAUERStain Technol196414127791Yes
182216901690.049.749.7Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
182316891689.047.247.2Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
1824101231687.2230.838.5Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
182516871687.058.758.7Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
182616871687.00.00.0Cerebral blood flow and oxygen consumption in man. N A LASSENPhysiol Rev195913645234Yes
182716871687.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GRAYJ Anat195913829103Yes
182816861686.037.437.4Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
182916851685.052.752.7Metallothionein. D H HamerAnnu Rev Biochem19863527054No
183016851685.043.043.0Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
183116831683.022.622.6RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
183233661683.091.345.6Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
183316831683.045.045.0Surface plasmon resonance sensors for detection of chemical and biological species. Jiri HomolaChem Rev200818229953No
183433661683.0196.398.2An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
183516821682.083.083.0Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
183616821682.029.929.9CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
183716811681.043.243.2Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
183816811681.014.014.0Chromatographic Separation Of Human Brain Gangliosides. L SVENNERHOLMJ Neurochem196314066623Yes
183916811681.062.162.1MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
184016801680.043.143.1Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
184116801680.073.673.6Mood and memory. G H BowerAm Psychol19817224324Yes
184216801680.038.238.2The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
184316791679.031.831.8Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
184416791679.045.045.0Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
184516781678.048.848.8Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
184616781678.033.633.6Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
184733561678.070.435.2Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
184816771677.058.258.2Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
184916771677.035.035.0Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
1850100571676.2346.557.8Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
185116761676.032.032.0Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
185233511675.582.841.4EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
185333501675.070.935.5The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
185416751675.094.594.5A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
185516741674.038.238.2The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
185616741674.089.589.5Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
185783691673.8297.559.5Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
185833461673.098.149.0Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
185950181672.7109.136.4Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
186033411670.564.132.0NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
186116701670.032.332.3Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
186216701670.063.463.4Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
186316701670.0120.1120.1The changing landscape of atherosclerosis. Peter LibbyNature202133883728No
186416681668.00.00.0Method for the determination of hexosamines in tissues. N F BOASJ Biol Chem195313117829Yes
186516671667.052.152.1Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
186616671667.049.249.2Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
186716671667.040.340.3Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
186816661666.041.341.3Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
186933321666.054.327.1The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T OMURA, R SATOJ Biol Chem196414209972Yes
187016651665.058.658.6Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
187116651665.043.443.4BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
187216641664.041.641.6Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
187333281664.072.136.0The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
187416641664.035.035.0Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
187533251662.560.330.1Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
187616621662.049.849.8Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
187716611661.049.149.1Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
187816611661.047.047.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
187916611661.036.536.5Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
188066401660.0152.138.0Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
188116601660.039.239.2Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
188216601660.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KETYPharmacol Rev195114833874Yes
188399511658.5225.637.6Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O LotvallNat Cell Biol200717486113Yes
188416581658.047.947.9The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
188549711657.0136.545.5Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
188633131656.582.741.4Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
188733131656.585.542.8Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
188816561656.056.856.8Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
188916561656.039.239.2Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
189033111655.571.235.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
189116551655.037.237.2A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
189216551655.037.437.4Upconversion and anti-Stokes processes with f and d ions in solids. Francois AuzelChem Rev200414719973Yes
189333091654.569.434.7Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
189433091654.593.846.9The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
189516541654.033.633.6Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
189666151653.8155.738.9Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
189716531653.063.163.1A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
189816521652.031.331.3The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
189933041652.097.548.8Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
190016501650.053.353.3Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
190116491649.036.236.2Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323Yes
190216481648.044.644.6Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
190316471647.050.150.1The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
190416471647.036.736.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
190516471647.023.023.0Structural considerations in the interaction of DNA and acridines. L S LERMANJ Mol Biol196113761054Yes
190616461646.033.233.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
190749381646.0118.039.3Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
190816461646.048.248.2Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
190916461646.045.045.0Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
191016461646.030.430.4Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
191132921646.080.640.3Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
191216451645.031.331.3Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
191332901645.092.246.1Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
191416441644.034.834.8Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
191549301643.3124.141.4Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
191649301643.3103.734.6Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
191716431643.041.341.3Aspergillus fumigatus and aspergillosis. J P LatgeClin Microbiol Rev199910194462No
191849291643.0152.350.8SCANPY: large-scale single-cell gene expression data analysis. F Alexander Wolf, Philipp Angerer, Fabian J TheisGenome Biol201829409532Yes
191916421642.083.383.3Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. Cynthia RudinNat Mach Intell201935603010Yes
192032831641.596.648.3Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
192116411641.044.944.9Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
192216411641.039.339.3The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
192332821641.066.033.0Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
192416411641.039.039.0Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
192516401640.046.746.7Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
192616401640.028.628.6Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
192732801640.0104.652.3How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
192832791639.558.929.4The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
192998351639.2315.952.6Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
193016391639.064.364.3An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
193116391639.027.627.6Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
193232781639.074.337.1Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
193332771638.593.246.6Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
193432771638.5130.365.2Interpreting findings from Mendelian randomization using the MR-Egger method. Stephen Burgess, Simon G ThompsonEur J Epidemiol201728527048Yes
193516381638.056.456.4Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
193632761638.065.532.8Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
193732761638.067.133.5Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassagueCell200617110329No
193849121637.3162.754.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
193916371637.047.047.0Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
194016371637.071.871.8The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
194132741637.091.845.9What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
194216371637.030.230.2Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
194316351635.070.970.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
194416351635.0102.0102.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MATTINGLYJ Clin Pathol196214471419Yes
194516351635.043.843.8Bioactive microbial metabolites. Janos BerdyJ Antibiot (Tokyo)200515813176No
194616341634.051.051.0Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
194716341634.049.849.8The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
194832681634.077.338.6Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
194916341634.030.330.3Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
195081691633.8282.656.5Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
195132671633.579.839.9Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
195232661633.092.746.4Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
195316331633.062.062.0Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
195432651632.571.035.5NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195516321632.030.230.2Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
195616321632.034.234.2From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
195716321632.029.729.7Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
195816311631.043.043.0n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
195932611630.5182.591.2Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J MARMUR, P DOTYJ Mol Biol196214470099Yes
196048911630.3132.644.2Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
196132601630.0124.662.3A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
196232601630.0114.757.4Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
196348891629.7124.141.4How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
196432581629.076.738.4Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
196516291629.028.528.5Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
196616291629.075.775.7Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
196716281628.058.258.2Cell damage in the brain: a speculative synthesis. B K SiesjoJ Cereb Blood Flow Metab19816276420No
196816281628.031.431.4The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
196932551627.574.537.2A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
1970130161627.0306.738.3Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, N Engl J Med200211832527Yes
197116271627.037.737.7Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
197216271627.067.367.3The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
197316261626.051.051.0Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
197416261626.052.352.3PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
197516251625.045.645.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
197616251625.037.037.0The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
197764971624.2205.651.4cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Ali Punjani, John L Rubinstein, David J Fleet, Marcus A BrubakerNat Methods201728165473Yes
197816241624.042.442.4Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
197932471623.596.448.2Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E Barlow, Pediatrics200718055651Yes
198016231623.0111.9111.9Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
198116231623.038.838.8Fast and robust fixed-point algorithms for independent component analysis. A HyvarinenIEEE Trans Neural Netw199918252563Yes
198216221622.046.146.1The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinasScience19883059497No
198316221622.029.929.9Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
198432441622.0117.158.5The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
198532431621.567.133.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
198616211621.040.440.4Molecular biology of prion diseases. S B PrusinerScience19911675487No
198716211621.071.571.5Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
198816211621.034.534.5Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
198916201620.047.347.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
199032381619.062.331.1Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
199148561618.7135.445.1The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
199232371618.578.239.1Obesity. David W Haslam, W Philip T JamesLancet200516198769No
199316181618.029.229.2Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
199416171617.026.226.2Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
199532341617.065.432.7Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
199616171617.035.535.5Thiazolidinediones. Hannele Yki-JarvinenN Engl J Med200415356308No
199732331616.5194.297.1A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
199816161616.034.334.3On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
199932321616.081.240.6Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
200016151615.033.633.6The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
200148441614.792.830.9The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jurg TschoppMol Cell200212191486Yes
200216141614.052.352.3Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
200348421614.0352.4117.5Ferroptosis: mechanisms, biology and role in disease. Xuejun Jiang, Brent R Stockwell, Marcus ConradNat Rev Mol Cell Biol202133495651No
200448401613.353.617.9Improved method for the determination of blood glutathione. E BEUTLER, O DURON, B M KELLYJ Lab Clin Med196313967893Yes
200516131613.067.267.2The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
200632251612.560.130.1Mutations affecting segment number and polarity in Drosophila. C Nusslein-Volhard, E WieschausNature19806776413Yes
200748371612.3115.538.5Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
200816121612.028.928.9Altering the genome by homologous recombination. M R CapecchiScience19892660260No
200948361612.0174.858.3Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
201016111611.029.329.3How cells read TGF-beta signals. J MassagueNat Rev Mol Cell Biol200011252892No
201116111611.00.00.0Discharge patterns and functional organization of mammalian retina. S W KUFFLERJ Neurophysiol195313035466Yes
201216111611.050.450.4Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
201332221611.077.438.7Dali server: conservation mapping in 3D. Liisa Holm, Paivi RosenstromNucleic Acids Res201020457744Yes
201448311610.3117.939.3Management of hepatocellular carcinoma. Jordi Bruix, Morris Sherman, Hepatology200516250051No
201532201610.091.245.6Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
201632191609.563.431.7Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
201716091609.051.451.4Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
201816091609.050.850.8The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
201916091609.056.156.1Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
202096491608.2276.446.1TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
202132151607.5111.055.5Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
202216071607.036.536.5Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
202316071607.032.732.7Drug discovery: a historical perspective. J DrewsScience200010720314No
202432121606.088.144.0Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
202516061606.050.650.6SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
202616061606.031.431.4RNA silencing in plants. David BaulcombeNature200415372043No
202732101605.093.046.5An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
202832091604.5113.056.5Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
202932091604.591.545.8Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
203032091604.557.228.6Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
203116041604.029.329.3The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
203232081604.061.030.5Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
203316041604.019.519.5Dithiothreitol, A New Protective Reagent For Sh Groups. W W CLELANDBiochemistry196414192894Yes
203480161603.2289.757.9Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Int J Surg201020171303No
203532061603.082.441.2Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
203616031603.059.959.91,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
203732051602.567.133.5Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
203848061602.088.329.4Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
203916021602.058.558.5Inflammation, metaflammation and immunometabolic disorders. Gokhan S HotamisligilNature201728179656No
204016011601.039.539.5Tumor necrosis factor (TNF). L J OldScience19852413547Yes
2041160071600.7375.037.5Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
204232011600.577.438.7Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
204316001600.049.149.1Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
204416001600.049.649.6The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
204516001600.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OUCHTERLONYActa Pathol Microbiol Scand195313079779Yes
204615991599.036.536.5VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
204731981599.077.438.7A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
204847951598.393.931.3Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
204915981598.034.134.1Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
205031951597.563.031.5The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
205115971597.031.331.3An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
205215971597.062.562.5Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
205331941597.077.939.0Abdominal obesity and metabolic syndrome. Jean-Pierre Despres, Isabelle LemieuxNature200617167477No
205415971597.084.384.3Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
205515961596.044.444.4Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
205615961596.032.732.7Sustainable hydrogen production. John A TurnerScience200415310892Yes
2057111691595.6353.550.5The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, J Clin Epidemiol200818313558Yes
205863801595.0209.852.5The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
205915941594.033.933.9Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
206063741593.5273.468.3NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
206179661593.2153.230.6Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
206231861593.076.638.3Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
206315921592.048.248.2Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
206431841592.078.839.4A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
206531841592.063.331.6Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
206631831591.560.330.1Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
206779571591.4341.068.2CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
206815911591.035.235.2Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
206915891589.042.842.8The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
207031781589.0104.952.5A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
207147651588.3120.740.2I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
207215881588.037.637.6HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
207331751587.596.248.1Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
207447621587.3114.838.3The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
207515871587.050.350.3The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
207615851585.039.339.3The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
207731701585.0100.450.2The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
207831701585.072.236.1Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
207915841584.046.246.2The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
208063341583.5205.751.4Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior PachterNat Biotechnol201627043002Yes
208115831583.035.235.2The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
208215831583.00.00.0Nutrition needs of mammalian cells in tissue culture. H EAGLEScience195513255879Yes
208315831583.033.133.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
2084110811583.0262.037.4Integrative genomics viewer. James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
208515831583.051.651.6The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FrohlichInt J Nanomedicine201223144561No
208615821582.080.780.7The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
208715821582.041.541.5Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
208831641582.061.730.9Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
208915811581.046.846.8Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
209015801580.041.241.2Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
209115801580.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HUMMELCan J Biochem Physiol195914405350Yes
209215801580.045.245.2The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
209315801580.040.840.8Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
209431581579.066.033.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
209515791579.052.552.5Biology of interleukin 1. C A DinarelloFASEB J19883277884No
209647371579.0156.552.2Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
209715791579.031.431.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
209815791579.032.832.8DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
209931571578.5119.659.8The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
210015771577.064.864.8Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
210115771577.044.944.9Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
2102126121576.5307.638.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
2103204811575.5514.539.6Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
210415751575.079.379.3Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
210515751575.00.00.0The generalisation of student's problems when several different population variances are involved. B L WELCHBiometrika194720287819Yes
210662881572.0154.238.5Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
210715711571.039.139.1Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
210815711571.047.147.1Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
210915701570.042.142.1Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
211015691569.058.958.9Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
211115691569.042.542.5Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
211215681568.044.344.3Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
211331351567.579.839.9Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
211462691567.2258.764.7Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
211562651566.2119.029.8A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
211615661566.038.538.5Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
211731311565.5100.750.4Mendelian randomization: genetic anchors for causal inference in epidemiological studies. George Davey Smith, Gibran HemaniHum Mol Genet201425064373No
211846951565.091.530.5Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
211915651565.044.744.7Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
212046921564.0150.050.0Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graca Raposo, Clotilde TheryAnnu Rev Cell Dev Biol201425288114No
212131261563.021.710.8Junctional complexes in various epithelia. M G FARQUHAR, G E PALADEJ Cell Biol196313944428Yes
212231261563.099.649.8Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
212362511562.8148.637.1Universal sample preparation method for proteome analysis. Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
212446871562.3140.646.9Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
212515621562.053.753.7The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
212646851561.7128.042.7Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
212731201560.038.619.3Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
212815601560.056.656.6Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
212915601560.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
213015601560.0194.2194.2Epidemiology of chronic kidney disease: an update 2022. Csaba P KovesdyKidney Int Suppl (2011)202235529086No
213131181559.067.833.9Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
213215571557.028.028.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
213315571557.058.058.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
213415561556.043.543.5The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
213515561556.042.542.5Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
213615561556.031.431.4Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
213731121556.095.047.5Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
213846661555.3103.034.3Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
213962201555.0178.644.6Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
214015551555.033.033.0The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
214115551555.057.457.4What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhaSoc Sci Med200919520474Yes
214215551555.036.736.7Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
214315551555.052.952.9Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
214415541554.059.859.8Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
214515541554.055.155.1Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
214615531553.055.755.7Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
214715521552.043.843.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
214815511551.036.336.3Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
214915511551.031.931.9Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
215062011550.2242.060.5Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Jack Bowden, George Davey Smith, Philip C Haycock, Stephen BurgessGenet Epidemiol201627061298Yes
215115501550.041.341.3The pollution of the marine environment by plastic debris: a review. Jose G B DerraikMar Pollut Bull200212405208No
215215501550.033.833.8Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
215315491549.044.944.9The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
215430971548.560.230.1Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
215530961548.099.149.5Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
215630961548.088.244.1Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
215715471547.043.043.0Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
215815471547.018.318.3A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
215930941547.096.548.2The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
216030931546.5185.392.7Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Helmut Sies, Dean P JonesNat Rev Mol Cell Biol202032231263No
216115461546.032.632.6Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
216246361545.3110.236.7Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
216315451545.040.340.3Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
2164108131544.7227.032.4Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
216530891544.596.048.0Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
216646331544.389.129.7A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
216715431543.091.691.6Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
216815431543.039.539.5Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
216930851542.570.935.5New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
217015411541.068.368.3Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
217115411541.054.454.4Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
217230811540.588.944.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
217346191539.7261.087.0MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
217415391539.030.030.0E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
217546171539.096.632.2The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
217630771538.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbruckGenetics194317247100Yes
217715381538.045.845.8Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
217815381538.098.198.1The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
217915371537.057.857.8Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
218046111537.0155.151.7Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
218115371537.037.637.6An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
218230741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G SCHMIDT, S J THANNHAUSERJ Biol Chem194521005717Yes
218315361536.048.348.3Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
218415351535.045.845.8The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
218530691534.566.833.4How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
218615341534.033.333.3The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
218746001533.3159.053.0Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
218815331533.056.956.9Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
218915331533.012.412.4The Relation Of Recombination To Mutational Advance. H J MULLERMutat Res196414195748Yes
219015321532.040.940.9Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
219115321532.045.545.5Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
219215321532.050.350.3Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
219315321532.032.332.3Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
219415321532.029.329.3A New Weighting System For Mean Surface Temperature Of The Human Body. N L RAMANATHANJ Appl Physiol196414173555Yes
219530641532.0148.474.2Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
219615311531.033.433.4Molecular themes in oncogenesis. J M BishopCell19911988146No
219715311531.021.321.3An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
219815301530.050.250.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
219915301530.035.435.4Proinflammatory cytokines. C A DinarelloChest200010936147No
220045881529.393.531.2TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
220115291529.049.949.9Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
220215291529.045.845.8Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
220315291529.033.833.8Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
220415291529.076.176.1Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
220515281528.030.730.7Antigen-Antibody Crossed Electrophoresis. C B LAURELLAnal Biochem196514302464Yes
220615281528.045.645.6Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
220715271527.044.644.6Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
220815271527.064.364.3Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
220930531526.559.929.9Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
221076321526.4264.552.9Salmon provides fast and bias-aware quantification of transcript expression. Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl KingsfordNat Methods201728263959Yes
221115261526.035.335.3Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
221245751525.0165.855.3Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
221315251525.038.638.6Early signals in the mitogenic response. E RozengurtScience19863018928No
221460981524.5130.532.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
221515241524.045.045.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
221615241524.043.543.5Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
221745691523.0141.347.1AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. G Paxinos, C R Watson, P C EmsonJ Neurosci Methods19806110810Yes
221815231523.057.557.5Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
221915231523.048.048.0Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
222015231523.040.940.9Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
222115231523.051.951.9Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
222230451522.558.729.4Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
2223106531521.9345.949.4Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
222430431521.590.045.0Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
222515211521.026.526.5Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
222615211521.025.225.2Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FUXEActa Physiol Scand Suppl196514319769Yes
222745631521.0101.733.9Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
222830421521.0336.2168.1Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Luke A McGuinness, Julian P T HigginsRes Synth Methods202132336025Yes
222945621520.7108.636.2Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
223030411520.5172.086.0Osteoarthritis. David J Hunter, Sita Bierma-ZeinstraLancet201931034380No
223115201520.026.926.9R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
223215201520.039.739.7Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
223360761519.0141.935.5CHARMM-GUI: a web-based graphical user interface for CHARMM. Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil ImJ Comput Chem200818351591No
223445561518.7104.334.8Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
223515171517.037.837.8Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
223630341517.087.043.5A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
223715171517.037.337.3Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
223815161516.039.739.7Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
223930321516.0103.051.5The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
224015161516.042.642.6Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
224115161516.059.159.1The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
224245461515.3124.041.3The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
224315141514.037.937.9Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
224445401513.397.332.4Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
224530261513.058.529.2Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
224615131513.042.642.6Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
224715131513.019.219.2Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
224815131513.022.122.1Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
224915121512.038.438.4The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
225030241512.084.742.4CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
225115121512.048.648.6AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
225230231511.561.830.9The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
225330221511.092.846.4Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
225415111511.044.544.5Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
225515111511.033.633.6Huntington's disease. Francis O WalkerLancet200717240289No
225645321510.7260.686.9Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A WINTER, E A RISLEY, G W NUSSProc Soc Exp Biol Med196214001233Yes
225715101510.036.136.1The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
225830201510.077.838.9Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
225915091509.049.349.3Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
226015091509.040.540.5Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
226115091509.096.796.7The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
226215091509.046.746.7Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
226330161508.098.849.4Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
226415081508.033.633.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
226530151507.5100.550.2Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
226615071507.050.250.2Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
226730141507.00.00.0Lactic dehydrogenase activity in blood. F WROBLEWSKI, J S LADUEProc Soc Exp Biol Med195513273400Yes
226815051505.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
226915041504.041.941.9Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
227030071503.556.728.4Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
227115031503.031.831.8Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
227230061503.056.428.2Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
227330051502.5114.057.0Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958Yes
227415021502.032.732.7Tumor suppressor genes. R A WeinbergScience19911659741No
227515021502.052.052.0Lyme disease. A C SteereN Engl J Med19892668764No
227615021502.017.817.8The mechanism of muscular contraction. H E HuxleyScience19694181952No
227715021502.038.038.0Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
227815021502.028.728.7The significance of responses of the genome to challenge. B McClintockScience198415739260No
227915021502.043.943.9The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
228015011501.044.944.9Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
228115011501.034.434.4Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
228215011501.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MOUNTCASTLEJ Neurophysiol195713439410Yes
228330011500.567.934.0Emerging roles of caspase-3 in apoptosis. A G Porter, R U JanickeCell Death Differ199910200555No
228430011500.570.835.4Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
228515001500.038.438.4Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
228614991499.043.243.2Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
228714981498.08.08.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SPERRYProc Natl Acad Sci U S A196314077501Yes
228814981498.040.140.1The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
228929961498.094.847.4Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BackhedNature201222972297No
229014971497.062.862.8The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
229129941497.069.834.9Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
229214971497.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
229359881497.0268.267.0Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron DoNat Genet201829686387Yes
229429931496.575.537.8Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
229514961496.038.238.2The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
229614961496.038.538.5Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
229714951495.036.836.8Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
229814951495.033.733.7Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
229914931493.036.136.1Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
230014931493.036.436.4Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
230114921492.039.039.0The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
230214921492.025.425.4The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
230314911491.033.833.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
230414911491.050.150.1Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
230529821491.097.448.7Nitric oxide synthases: regulation and function. Ulrich Forstermann, William C SessaEur Heart J201221890489No
230644721490.7147.249.1Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
230744701490.045.915.3The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T DODGE, C MITCHELL, D J HANAHANArch Biochem Biophys196314028302Yes
230814881488.053.253.2The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
230929761488.075.237.6Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
231014881488.039.239.2Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
231114881488.030.330.3The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
231214881488.051.451.4Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
231314881488.052.352.3Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
231429751487.5107.153.5Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
231514871487.040.840.8Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DomlingChem Rev200616402771No
231614861486.033.233.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
231729721486.097.548.8Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
231829711485.5235.3117.7Gut microbiota in human metabolic health and disease. Yong Fan, Oluf PedersenNat Rev Microbiol202132887946No
231914851485.040.540.5Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
232014851485.030.630.6Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
232159381484.5247.862.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
232229691484.567.533.8Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
2323133571484.1409.645.5The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
232414841484.034.834.8Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
232514841484.026.326.3Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
232614841484.00.00.0An approximate distribution of estimates of variance components. F E SATTERTHWAITEBiometrics194620287815Yes
232714831483.034.234.2The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
232829631481.578.139.0Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
232914811481.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
233014811481.060.660.6Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
233114801480.031.631.6Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
233244391479.795.932.0OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
233388781479.7262.743.8The Molecular Signatures Database (MSigDB) hallmark gene set collection. Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo TamayoCell Syst201526771021Yes
233414791479.042.942.9Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
233514781478.010.710.7Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HUXLEYJ Mol Biol196314064165Yes
233614781478.034.334.3Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NOWELLCancer Res196014427849Yes
233729551477.591.946.0The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
233829551477.576.138.0The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
233929551477.588.644.3DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
234014771477.035.235.2The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
234129531476.595.948.0The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
234229531476.568.034.0The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
234329531476.567.833.9Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
234429531476.581.840.9A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marcais, Carl KingsfordBioinformatics201121217122Yes
234514761476.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H ROSENArch Biochem Biophys195713412116Yes
234614751475.033.633.6PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
234714751475.042.042.0Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
234873741474.8266.253.2Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
234914741474.053.253.2The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
235014741474.054.554.5Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
235129481474.0157.578.8The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G GRAY, V P WHITTAKERJ Anat196213901297Yes
235229481474.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
235329471473.5153.276.6Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
235414731473.030.730.7Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
235529451472.583.441.7A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
235614721472.038.638.6Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
235714721472.0100.3100.3A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
235829431471.5102.451.2Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
235914711471.030.430.4Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
236014701470.043.743.7Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
236129401470.076.238.1Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
236229391469.563.531.8Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
236358771469.2296.774.2Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E HoltPLoS Comput Biol201728594827Yes
236414691469.047.747.7A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
236573451469.0170.034.0Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J BartonBioinformatics200919151095Yes
236614691469.043.143.1The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
236729381469.081.440.7Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
236814681468.037.937.9Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
236929351467.554.127.1T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
237029351467.599.249.6Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
237114671467.038.238.2A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
237214671467.025.825.8The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
237329331466.581.740.9The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
237414651465.036.436.4Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
237514651465.071.371.3Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
237629291464.555.127.6Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
237714641464.033.533.5Simple methods for "staining with lead" at high pH in electron microscopy. M J KARNOVSKYJ Biophys Biochem Cytol196114454024Yes
237814631463.034.334.3Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
237914621462.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
238043831461.092.430.8NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
238114611461.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BUSHBiochem J195214915960Yes
238214611461.036.436.4The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
238343811460.394.431.5Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornoe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
238414601460.020.820.8Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
238529181459.085.943.0The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
238629181459.054.727.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
238729171458.5104.452.2Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
238829161458.085.342.6Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
238943731457.7150.450.1Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
239043731457.7185.561.8Hepatocellular carcinoma. Alejandro Forner, Maria Reig, Jordi BruixLancet201829307467No
239129151457.557.428.7Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
239214571457.044.744.7Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
239343701456.786.328.8The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
239414561456.033.533.5Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
239514561456.029.029.0Human natural killer cells. Michael A CaligiuriBlood200818650461No
239629121456.066.733.4Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
239714561456.061.361.3Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
239829111455.562.631.3The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
239929111455.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H CLARKE, J CASALSAm J Trop Med Hyg195813571577Yes
240029111455.5102.251.1Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
240114551455.029.229.2The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
240214551455.041.841.8Function and information content of DNA methylation. Dirk SchubelerNature201525592537No
2403101821454.6403.357.6Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
240429081454.077.438.73' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
240514541454.035.635.6General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
240614541454.040.140.1Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
240772701454.0204.640.9Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
240814541454.031.331.3Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
240914531453.031.331.3The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
241014531453.057.657.6Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
241129051452.576.038.0Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
241243571452.392.630.9Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
241329041452.0105.752.9Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
241458081452.0241.260.3Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
241529031451.579.539.8A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
241629031451.562.831.4Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
241743541451.389.229.7Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
241829021451.071.235.6The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
241914511451.032.732.7Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
242014511451.056.956.9Diagnostic and Statistical Manual of Mental Disorders (DSM). Dolores Elaine BattleCodas201324413388Yes
242129011450.579.839.9Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
242243511450.3108.636.2LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
242314501450.084.784.7A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
242429001450.084.842.4Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
242514501450.039.439.4A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
242643501450.0134.144.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
242714491449.048.348.3Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
242814491449.041.341.3The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
242928981449.052.726.4Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
243028971448.578.339.1Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
243128971448.568.034.0The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
243214481448.034.834.8Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
243328961448.065.532.8Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
243414481448.027.527.5Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
243528951447.50.00.0Virus interference. I. The interferon. A ISAACS, J LINDENMANNProc R Soc Lond B Biol Sci195713465720Yes
243686831447.2310.151.7Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
243743411447.0130.143.4Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
243857871446.8153.538.4The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
243928921446.070.335.1Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
244028921446.066.233.1Inflammation, stress, and diabetes. Kathryn E Wellen, Gokhan S HotamisligilJ Clin Invest200515864338No
244114461446.039.639.6Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
244214461446.041.041.0Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
244372281445.6270.754.1DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
244472261445.2154.831.0Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
244514451445.042.142.1Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
244628891444.50.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J BLOOM, W W RICHARDSONBr J Cancer195713499785Yes
244728891444.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D DAVIS, E S MINGIOLIJ Bacteriol195015436457Yes
244828881444.0115.958.0Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
244943321444.0114.738.2TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
245014441444.031.031.0Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
245114441444.034.534.5TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
245228871443.580.540.2Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluisio J D Barros, Vania N HirakataBMC Med Res Methodol200314567763Yes
245357721443.0204.851.2Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
245443281442.7202.967.6Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
245528851442.536.918.4Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A DAHLSTROEM, K FUXEActa Physiol Scand Suppl196414229500Yes
245614421442.046.946.9Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
245743251441.786.628.9Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
245814411441.037.037.0Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
245943231441.0156.952.3Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
246086441440.7213.135.5A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
246114401440.054.454.4The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
246228791439.5174.387.2A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H ANTON, D F SAYREJ Pharmacol Exp Ther196214013351Yes
246314391439.049.149.1Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
246414381438.026.626.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
246528751437.559.229.6LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
246628741437.070.435.2Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
246714371437.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D POULIKNature195713493570Yes
246814371437.048.048.0Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
246928731436.571.335.6Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
247028721436.069.935.0Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
247114361436.042.942.9Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
247214361436.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F ROSENBLATTPsychol Rev195813602029Yes
247314361436.033.033.0The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
247414361436.033.233.2Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
247514361436.045.045.0How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
2476229611435.1615.138.4New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
247714351435.067.367.3The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
247814351435.036.136.1The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
247914351435.00.00.0The critical incident technique. J C FLANAGANPsychol Bull195413177800Yes
248014341434.034.334.3Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
248128681434.0111.855.9Using Effect Size-or Why the P Value Is Not Enough. Gail M Sullivan, Richard FeinnJ Grad Med Educ201223997866Yes
248214331433.016.916.9Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
248314331433.016.616.6Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WYMANAdv Protein Chem196414268785No
248428661433.077.438.7Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
248542971432.399.433.1Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
248614321432.030.730.7The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
248714321432.040.340.3Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
248814321432.086.286.2Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
248914311431.046.246.2Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
249014311431.029.629.6A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
249128621431.070.635.3An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
249214311431.030.430.4Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
249314311431.035.435.4The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
249414311431.070.570.5SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
249542901430.0139.746.6Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
249614301430.054.054.0Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
249714301430.033.133.1Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
249842881429.3111.337.1Nitric oxide and peroxynitrite in health and disease. Pal Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
249914291429.029.329.3Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
250028581429.083.041.5Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
250142871429.0107.936.0Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
250214291429.036.636.6T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
250328571428.566.133.0C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
250428571428.590.345.1MissForest--non-parametric missing value imputation for mixed-type data. Daniel J Stekhoven, Peter BuhlmannBioinformatics201222039212Yes
250528571428.5118.359.1AMPK: guardian of metabolism and mitochondrial homeostasis. Sebastien Herzig, Reuben J ShawNat Rev Mol Cell Biol201828974774No
250614281428.050.250.2Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
250714281428.058.658.6Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
250814281428.035.135.1Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
250985671427.8294.049.0StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L SalzbergNat Biotechnol201525690850Yes
251014271427.012.812.8The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
251128511425.577.538.8Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
251214251425.038.238.2Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
251328481424.088.844.4Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
251428481424.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L HODGKIN, B KATZJ Physiol194918128147Yes
251514241424.036.436.4Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
251642711423.792.330.8Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
251714231423.026.926.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
251828461423.066.833.4Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
251928451422.581.140.5Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
252028451422.5103.051.5The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
252114221422.031.731.7Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
252214221422.027.927.9Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
252314221422.054.854.8How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
252414221422.045.145.1ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Tristan Ian CrollActa Crystallogr D Struct Biol201829872003Yes
252585271421.2206.334.4An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
252614211421.081.081.0Head and Neck Cancer. Laura Q M ChowN Engl J Med202031893516No
252714201420.044.044.0The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
252814201420.054.854.8The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
252928391419.566.133.0Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
253014191419.024.424.4The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
253128381419.095.647.8A new scale of social desirability independent of psychopathology. D P CROWNE, D MARLOWEJ Consult Psychol196013813058Yes
253214191419.027.927.9Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
253328381419.058.029.0The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
253428371418.588.444.2CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. Jing Huang, Alexander D MacKerellJ Comput Chem201323832629Yes
253514181418.029.029.0Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
253614181418.036.936.9Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
253728361418.084.442.2bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
253814171417.050.650.6Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
253914171417.033.233.2The basic science of gene therapy. R C MulliganScience19938493530No
254014171417.039.539.5Endometriosis. Serdar E BulunN Engl J Med200919144942No
254114161416.025.225.2Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
254214161416.031.431.4Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
254314161416.038.738.7Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
254414161416.032.532.5What is a support vector machine? William S NobleNat Biotechnol200617160063No
254514161416.049.249.2The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
254614151415.050.150.1The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
254714151415.040.140.1Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
254828291414.582.741.4The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
254914141414.028.928.9Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
255014131413.035.935.9The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
255128261413.069.234.6Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
255242381412.7116.939.0A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
255314121412.025.225.2c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
255456481412.0191.948.0Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
255528221411.082.441.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
255628221411.071.135.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
255714111411.029.129.1Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
255870531410.6250.150.0The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
255928211410.598.549.2Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
256028201410.042.321.1Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
256114091409.025.925.9NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
256214091409.046.246.2Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
256328171408.581.440.7Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
256456341408.5148.037.0AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
256514081408.031.831.8Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
256628151407.597.949.0Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
256714071407.032.532.5Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
256814071407.043.443.4The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
256914071407.032.632.6Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
257028121406.0105.452.7Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
257128121406.054.327.1Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
257214061406.041.541.5The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
257328111405.563.931.9Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
257428111405.568.834.4Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
257514051405.028.828.8HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
257614051405.031.031.0Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
257714051405.042.542.5Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
257828091404.566.933.5Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
257928081404.0106.253.1Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
258014041404.043.043.0Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
258184241404.0219.236.5Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
258256151403.8142.435.6The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan Shaw, Lancet200516182882Yes
258370181403.6354.370.9Standards for reporting qualitative research: a synthesis of recommendations. Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A CookAcad Med201424979285Yes
258428071403.562.631.3Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
258528071403.598.249.1Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Christoph Hafemeister, Rahul SatijaGenome Biol201931870423Yes
258628061403.0170.985.5Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
258714031403.041.241.2Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
258828061403.073.436.7New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
258928041402.094.647.3Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
259014021402.047.547.5Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
259114021402.030.730.7Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
259242061402.079.726.6Exosomes: composition, biogenesis and function. Clotilde Thery, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
259314021402.066.066.0Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Hae-Young KimRestor Dent Endod201323495371Yes
259414021402.052.452.4How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
259528021401.061.830.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
259614011401.034.234.2Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
259728021401.067.934.0The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
259828021401.0114.057.0Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
259928011400.572.036.0miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
260028001400.0129.864.9Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
260114001400.021.221.2A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
260214001400.048.748.7Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
260355991399.8140.635.1Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
260441991399.795.831.9Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
260513991399.040.740.7Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
260669951399.0130.026.0Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mader, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260713991399.035.135.1The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
260827971398.561.830.9Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
260941951398.383.727.9Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
2610139761397.6515.851.6MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
261113971397.025.125.1ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
261241871395.793.431.1Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
261327911395.591.145.5A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
261427911395.560.630.3An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
261527911395.581.640.8Microdetermination of long-chain fatty acids in plasma and tissues. V P DOLE, H MEINERTZJ Biol Chem196013817286Yes
261613941394.038.838.8A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
261713941394.030.730.7Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
261813941394.022.222.2Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
261927881394.061.330.6Immunoassay of endogenous plasma insulin in man. R S YALOW, S A BERSONJ Clin Invest196013846364Yes
262027871393.5101.150.5Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
262141801393.3105.535.2Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
262213931393.031.731.7A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
262397501392.9284.140.6Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
262413921392.040.840.8Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
262513921392.026.326.3microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
262613921392.034.334.3Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
262727841392.070.935.5Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
262827831391.559.829.9NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
262913911391.060.260.2Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
263013911391.027.927.9Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SudhofNature200818923512No
263127791389.561.630.8The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
263213891389.024.124.1Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
263313891389.025.525.5Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
263469441388.8185.337.1Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
263541651388.390.930.3Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
263613881388.029.529.5Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
263713871387.072.672.6Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
263813871387.031.131.1The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
263913871387.038.038.0The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
264013871387.028.328.3Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
264113871387.032.232.2Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
264213861386.015.115.1Central dogma of molecular biology. F CrickNature19704913914No
264313861386.029.529.5Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
264413861386.035.135.1Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
264527711385.571.235.6A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
264627711385.555.527.8Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
264755411385.2118.729.7Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
264827701385.083.141.5Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
264913851385.027.527.5The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
265041551385.0261.287.1Correlation Coefficients: Appropriate Use and Interpretation. Patrick Schober, Christa Boer, Lothar A SchwarteAnesth Analg201829481436No
265141531384.3128.442.8Mendelian randomization analysis with multiple genetic variants using summarized data. Stephen Burgess, Adam Butterworth, Simon G ThompsonGenet Epidemiol201324114802Yes
265213841384.023.923.9Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
265313831383.027.727.7Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
265413831383.044.044.0Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
265513831383.043.043.0Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
265613821382.043.243.2Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
265727641382.077.038.5Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
265813821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SCHNEIDERJ Biol Chem194818886166Yes
265913821382.064.164.1Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
266027631381.570.335.1A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
266113811381.010.910.9Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
266213811381.034.734.7Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
266313811381.036.136.1Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
266441431381.0118.839.6Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
266513811381.032.432.4Hydrogen sulphide and its therapeutic potential. Csaba SzaboNat Rev Drug Discov200717948022No
266627611380.554.527.2Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
266727611380.50.00.0Construct validity in psychological tests. L J CRONBACH, P E MEEHLPsychol Bull195513245896Yes
266813801380.065.865.8The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
266913801380.048.948.9The non-canonical NF-κB pathway in immunity and inflammation. Shao-Cong SunNat Rev Immunol201728580957No
267027581379.096.348.1A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
267113791379.028.428.4Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
267213791379.039.239.2Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
267313791379.036.536.5Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
267413781378.031.031.0Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
267513781378.029.029.0Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
267613781378.040.440.4Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
267727541377.070.335.1Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WuthrichBiochem Biophys Res Commun19836307308Yes
267813771377.036.736.7Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
267982571376.2203.433.9Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat RoblesBioinformatics200516081474Yes
2680165111375.9412.634.4Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, J Gerontol A Biol Sci Med Sci200111253156Yes
268113751375.011.611.6Immunological function of the thymus. J F MILLERLancet196114474038Yes
268213741374.023.623.6SUMO: a history of modification. Ronald T HayMol Cell200515808504No
268327481374.0120.160.0New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Anushka Dongre, Robert A WeinbergNat Rev Mol Cell Biol201930459476No
268427471373.550.925.4STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
268527461373.0163.781.8A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
268627451372.5140.770.3Depression. Gin S Malhi, J John MannLancet201830396512No
268754891372.2125.531.4The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
268827441372.054.327.1Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
268913721372.041.941.9Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
269054881372.0261.065.2The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
269113711371.049.249.2Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
269213711371.032.332.3Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
269341131371.0146.248.7A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
269427421371.00.00.0The respiratory chain and oxidative phosphorylation. B CHANCE, G R WILLIAMSAdv Enzymol Relat Subj Biochem195613313307Yes
269513701370.022.922.9Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
269613701370.035.235.2Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
269741091369.7119.739.9Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
269827391369.554.427.2Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
269927381369.056.228.1Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
270013691369.046.246.2Interleukin-1. C A DinarelloRev Infect Dis19846369481No
270113691369.043.543.5History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
270213691369.049.149.1Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
270327371368.553.826.9A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
270413681368.032.732.7Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
270513681368.038.938.9Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
270613681368.00.00.0On the psychophysical law. S S STEVENSPsychol Rev195713441853Yes
270713681368.027.327.3Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
270827351367.567.133.5Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
270913671367.00.00.0The relation of the trail making test to organic brain damage. R M REITANJ Consult Psychol195513263471Yes
271013671367.031.031.0Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
271113671367.033.133.1Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
271227331366.5100.450.2Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
271313661366.027.127.1Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
271413661366.030.330.3Optical microcavities. Kerry J VahalaNature200312917698Yes
271513661366.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SMITHIESBiochem J195913638269Yes
271613651365.031.831.8Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
271727291364.584.042.0Liquid phase condensation in cell physiology and disease. Yongdae Shin, Clifford P BrangwynneScience201728935776No
271813641364.046.746.7Multiple calcium channels and neuronal function. R J MillerScience19872432656No
271913641364.00.00.0The anterior approach for removal of ruptured cervical disks. R B CLOWARDJ Neurosurg195813599052Yes
272013641364.035.435.4Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
272127261363.076.738.4Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
272213631363.084.784.7COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
272313621362.033.733.7A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
272413621362.049.549.5A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
272554441361.0105.326.3Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
272613611361.035.235.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
272781641360.7226.437.7Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
272813601360.045.045.0Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
272913591359.041.141.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
273013591359.023.223.2Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
273140771359.083.928.0Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
273227181359.056.628.3Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
273313581358.041.741.7Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
273413581358.042.242.2The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
273513581358.035.735.7Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
273613581358.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CAULFIELDJ Biophys Biochem Cytol195713475399Yes
273740731357.799.733.2Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C Kearon, J Thromb Haemost200515842354Yes
273827151357.572.436.2Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
273927151357.569.234.6Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
2740162881357.31138.494.9The REDCap consortium: Building an international community of software platform partners. Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, J Biomed Inform201931078660Yes
274154291357.2116.129.0A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
274227141357.039.419.7Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
274327141357.072.336.1A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
274413571357.028.528.5Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
274554271356.8124.331.1Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
274627131356.566.133.0Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
274713561356.037.837.8Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
274813561356.057.957.9Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
274913561356.029.829.8Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
275027111355.547.023.5Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
275113551355.048.248.2The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
275213551355.063.463.4Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
275313551355.043.143.1An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
275427101355.061.830.9NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
275513551355.023.123.1The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
275613551355.029.529.5The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
275713551355.035.835.8How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
275840641354.790.930.3Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
275927091354.597.949.0AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
276013541354.028.428.4The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
276127081354.061.130.6The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
276213531353.025.825.8Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
276313531353.00.00.0Comparing individual means in the analysis of variance. J W TUKEYBiometrics194918151955Yes
276440581352.749.616.5Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D SABATINI, K BENSCH, R J BARRNETTJ Cell Biol196313975866Yes
276527021351.0122.561.2Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
276613511351.034.134.1Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
276713511351.024.324.3Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
276813511351.032.732.7N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
276913501350.035.435.4Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
277040481349.3127.742.6Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
277126981349.068.434.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
277226981349.058.829.4A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
277313491349.035.435.4Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
277426971348.561.230.6Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
277513481348.043.143.1Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
277613481348.044.244.2The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
277740431347.7124.641.5MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
277853901347.5170.042.5Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
277913471347.033.433.4Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
278013471347.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WADDELLJ Lab Clin Med195613346201Yes
278126941347.079.239.6Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
278267351347.0208.341.7CD-HIT: accelerated for clustering the next-generation sequencing data. Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong LiBioinformatics201223060610Yes
278326941347.0104.352.1Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
278426931346.557.428.7Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
278526931346.555.727.9Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
278626931346.552.226.1Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
278753861346.5119.429.9Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
278826931346.589.544.8Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
278913461346.017.017.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
279013461346.023.223.2Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
279126911345.5134.367.2A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
279226891344.586.643.3Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
279326891344.568.534.2Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
279413441344.035.535.5Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
279513441344.044.044.0Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
279640321344.099.233.1Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
279713441344.065.465.4Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Nicholas A MeanwellJ Med Chem201829400967No
279853741343.5298.874.7Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
2799134321343.2463.846.4The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
280013431343.046.446.4Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
280126841342.063.831.9Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
280213421342.039.439.4Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
280353671341.8159.639.9Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
280426831341.5203.4101.7Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
280513411341.065.865.8Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
280613411341.046.846.8Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
280726821341.074.437.2Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
280880451340.8282.747.1Second-generation PLINK: rising to the challenge of larger and richer datasets. Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J LeeGigascience201525722852Yes
280953621340.5186.746.7MultiQC: summarize analysis results for multiple tools and samples in a single report. Philip Ewels, Mans Magnusson, Sverker Lundin, Max KallerBioinformatics201627312411Yes
281013401340.035.935.9Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
281126801340.071.735.9The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
281226801340.077.638.8Opportunities and challenges for a sustainable energy future. Steven Chu, Arun MajumdarNature201222895334No
281353571339.2145.736.4GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
281413391339.055.355.3Error in medicine. L L LeapeJAMA19947503827Yes
281513391339.034.734.7Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
281613381338.034.934.9The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
281726761338.044.822.4Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
281813381338.035.635.6The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
281913381338.045.245.2Electrolytes and interphases in Li-ion batteries and beyond. Kang XuChem Rev201425351820Yes
282040121337.392.931.0Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
282113371337.045.145.1The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
282213371337.025.225.2A modified procedure for lead staining of thin sections. G MILLONIGJ Biophys Biochem Cytol196114474176Yes
282340111337.097.932.6Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
282413361336.051.551.5Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
282513361336.062.862.8Cellular resistance to infection. G B MACKANESSJ Exp Med196214467923Yes
282640071335.783.627.9A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
282726711335.572.636.3What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
282840061335.3194.564.8Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
282913351335.024.624.6Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
283026701335.079.539.8Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
283126701335.087.443.7Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
283213351335.059.759.7The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
283326681334.049.424.7New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
283413341334.050.650.6Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
283580041334.0234.439.1Prodigal: prokaryotic gene recognition and translation initiation site identification. Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J HauserBMC Bioinformatics201020211023Yes
283613341334.062.862.8Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
283726671333.561.930.9Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
2838106661333.2258.732.3A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
283926661333.0100.050.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
284013331333.029.929.9Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
284113331333.027.827.8Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
284213331333.032.032.0Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
284313331333.027.227.2Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
284413321332.029.829.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
284513321332.046.246.2Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
284613321332.032.632.6Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
284713321332.052.652.6The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615Yes
284813311331.033.433.4Supported membranes: scientific and practical applications. E SackmannScience19968539599No
284913311331.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BERKSONBiometrics194621001024Yes
285053231330.8145.836.5Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
285126611330.578.239.1Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
2852119721330.2289.332.1MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
285353201330.0129.632.4Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
285413301330.024.824.8Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
285539901330.094.531.5Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
285626601330.064.332.1Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
285713301330.034.634.6The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
285826591329.552.326.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
285926581329.065.232.6Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
286026581329.058.229.1Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
286113291329.057.457.4Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
286226561328.059.929.9Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
286313281328.032.332.3Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
286413281328.030.130.1Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
286526561328.084.442.2A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschopeJ Am Coll Cardiol201323684677No
286653111327.8122.130.5Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar von Heijne, Soren BrunakJ Mol Biol200415223320Yes
286726551327.574.537.2Inflammatory mechanisms in obesity. Margaret F Gregor, Gokhan S HotamisligilAnnu Rev Immunol201121219177No
286839821327.3120.140.0Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
286953091327.2230.857.7Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GokerBMC Bioinformatics201323432962Yes
287013271327.026.926.9The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
287113271327.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
287213261326.022.622.6Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
287339751325.096.332.1The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
287453001325.0132.933.2Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
287513251325.037.537.5Plant productivity and environment. J S BoyerScience198217808529Yes
287613251325.00.00.0A simple objective technique for measuring flexibility in thinking. E A BERGJ Gen Psychol194818889466Yes
287726491324.556.928.4Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
287826481324.090.745.4Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
287926471323.555.127.6The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
288013231323.054.954.9A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
288113231323.028.828.8Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
288213231323.029.929.9Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
288326451322.564.932.5Interneurons of the hippocampus. T F Freund, G BuzsakiHippocampus19968915675No
288413221322.036.036.0The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
288526441322.050.225.1Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
288613221322.034.734.7Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
288713211321.056.456.4Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
288813211321.030.030.0Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
288913211321.043.343.3The frailty syndrome: definition and natural history. Qian-Li XueClin Geriatr Med201121093718No
289026421321.093.346.6Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde TheryCell201626967288No
289126411320.567.233.6Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
289266001320.0161.832.4Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
289326401320.073.036.5Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
289413201320.043.643.6Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamas RoszerMediators Inflamm201526089604No
289526391319.545.822.9DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
289626381319.040.420.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
289713191319.021.921.9Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
289813191319.035.535.5Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
289926361318.059.429.7Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
290039531317.791.630.5Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Ronnback, Elisabeth HanssonNat Rev Neurosci200616371949No
290113171317.032.232.2The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
290213171317.033.933.9The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
290313161316.047.047.0The case for motivated reasoning. Z KundaPsychol Bull19902270237No
290426321316.083.041.5Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
290513161316.031.131.1Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
290613161316.031.531.5Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
290713161316.034.834.8The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
290813161316.00.00.0Intra-sexual selection in Drosophila. A J BATEMANHeredity (Edinb)194818103134Yes
290913151315.037.237.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
291013151315.033.133.1Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
291126301315.059.629.8Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
291213141314.035.535.5The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
291313141314.026.226.2Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
291439411313.7115.338.4The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
291539411313.7162.754.2Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
291613131313.052.452.4Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
291726261313.057.528.8Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
291826251312.543.621.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
291952501312.5135.033.8Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
292013121312.061.361.3New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
292126241312.077.238.6The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
292226231311.523.811.9Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
292326231311.549.524.8Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
292426231311.546.523.2Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
292526231311.50.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A EDMONDSON, P E STEINERCancer195413160935Yes
292613111311.034.434.4Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
292726221311.067.833.9A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
292813111311.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F SCHOLANDERJ Biol Chem194720281644Yes
292913101310.027.527.5Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
293013101310.023.123.1CD95's deadly mission in the immune system. P H KrammerNature200011048730No
293139291309.7105.535.2Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
293226191309.5106.353.1Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
293326191309.555.127.6Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
293426191309.565.732.9Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
293526181309.059.329.6Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
293613091309.039.439.4Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
293713091309.025.225.2Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
293826181309.079.339.6Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
293913091309.049.349.3Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
294013091309.075.375.3Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. Janice M MorseQual Health Res201526184336Yes
294139261308.7104.434.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Gunter Oberdorster, Eva Oberdorster, Jan OberdorsterEnviron Health Perspect200516002369No
294226171308.561.330.6Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
294313081308.030.730.7Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
294426161308.066.033.0Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
294513081308.043.143.1The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
294639231307.7173.257.7In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
294726151307.554.227.1Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
294826141307.063.031.5The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
294926131306.571.135.5Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
295039191306.3121.040.3Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
295178371306.2223.437.2The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
295213061306.043.343.3Bee and wasp venoms. E HabermannScience19724113805No
295313061306.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FARRJ Infect Dis195813611294Yes
295413061306.037.737.7Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
295552221305.5107.126.8Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
295626101305.056.628.3Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
295713051305.028.728.7Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
295826101305.067.733.9Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
295926101305.072.636.3Accurate and robust brain image alignment using boundary-based registration. Douglas N Greve, Bruce FischlNeuroimage200919573611Yes
296013051305.060.960.9Embracing the unknown: disentangling the complexities of the soil microbiome. Noah FiererNat Rev Microbiol201728824177No
296126091304.551.225.6ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
296213041304.044.544.5Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
296313041304.066.166.1Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Dimitrios TsikasAnal Biochem201727789233No
296426071303.577.238.6An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
296526061303.050.025.0CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
296626031301.583.541.8Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
296713011301.066.866.8Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
296813011301.032.232.2Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
296913001300.00.00.0Agammaglobulinemia. O C BRUTONPediatrics195214929630Yes
297013001300.026.626.6The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
297125991299.544.822.4Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
297225991299.568.934.5Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
297312991299.083.983.9The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
297412991299.017.417.4The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
297564951299.0179.836.0Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
297612991299.058.658.6Body Mass Index: Obesity, BMI, and Health: A Critical Review. Frank Q NuttallNutr Today201527340299Yes
297725981299.0146.073.0Sarcopenia. Alfonso J Cruz-Jentoft, Avan A SayerLancet201931171417No
297838961298.794.531.5Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
297925971298.599.649.8Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
298012981298.028.828.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
298112981298.032.532.5Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
298212981298.030.930.9Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
298312981298.026.126.1The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
2984142731297.5390.935.5International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
298512971297.048.148.1Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
298612971297.030.930.9Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
298712971297.034.634.6Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
298812971297.037.837.8Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
298938901296.7207.969.3Improved metagenomic analysis with Kraken 2. Derrick E Wood, Jennifer Lu, Ben LangmeadGenome Biol201931779668Yes
299012961296.045.645.6The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
299125921296.078.539.2A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
299212961296.030.730.7Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
299312961296.026.926.9Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
299425911295.552.626.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
299512951295.033.633.6The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
299625891294.5110.755.4Activation of apoptosis signalling pathways by reactive oxygen species. Maureen Redza-Dutordoir, Diana A Averill-BatesBiochim Biophys Acta201627646922No
299712941294.034.234.2Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
299812941294.043.443.4Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
299912941294.00.00.0A production of amino acids under possible primitive earth conditions. S L MILLERScience195313056598Yes
300012941294.028.728.7Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
300112941294.053.153.1The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
300238811293.7131.643.9The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
300338801293.390.630.2Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
300464661293.2312.462.5Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
300512931293.042.642.6Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
300612931293.032.132.1Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
300712931293.032.232.2Drug delivery and targeting. R LangerNature19989579855No
300812931293.028.728.7Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
300912931293.030.130.1Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
301012921292.042.242.2Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
301112921292.030.930.9Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
301225841292.094.947.5The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
301338761292.096.232.1Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
301425821291.047.823.9The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
301512911291.030.130.1Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
301625821291.044.322.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
301712911291.039.039.0Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
301825821291.066.733.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
301938721290.790.130.0METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Goncalo R AbecasisBioinformatics201020616382Yes
302025811290.532.116.1A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H VANDENDOOL, P D KRATZJ Chromatogr196314062605Yes
302112901290.044.044.0Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
302238701290.088.929.6Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
302325801290.087.543.8Inflammasomes: mechanism of assembly, regulation and signalling. Petr Broz, Vishva M DixitNat Rev Immunol201627291964No
302412901290.053.253.2Overview of the IL-1 family in innate inflammation and acquired immunity. Charles A DinarelloImmunol Rev201829247995No
302538691289.7109.036.3HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
302612891289.027.327.3S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
302725781289.0136.468.2Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R GUILLARD, J H RYTHERCan J Microbiol196213902807Yes
302812891289.034.534.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
302912891289.026.726.7VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
303025781289.065.332.6BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
303125771288.5173.186.5The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
303212881288.036.736.7Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BoyumScand J Clin Lab Invest Suppl19684179066Yes
303312881288.039.439.4Somatostatin. S ReichlinN Engl J Med19836139753No
303412881288.033.633.6Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
303512881288.032.532.5Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
303625761288.056.628.3Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
303777271287.8311.651.9Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark WymerHepatology201626707365No
303825751287.589.945.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
303925741287.060.730.4Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
304012871287.024.824.8Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
304112871287.038.038.0A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
304225731286.549.324.6Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
304325731286.579.539.8The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
304412861286.038.838.8Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
304512861286.028.528.5Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
304625711285.598.649.3A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
304725711285.548.324.1Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
304812851285.014.314.3A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
304912851285.029.829.8Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
305012851285.024.224.2Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
305125691284.573.036.5Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
305212841284.029.929.9Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
305312831283.029.329.3Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
305425661283.061.730.9Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
305525661283.058.829.4ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoit D'Autreaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
305612831283.044.144.1Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjostromJ Intern Med201323163728No
305725661283.0116.858.4An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Jesper L R Andersson, Stamatios N SotiropoulosNeuroimage201626481672Yes
305812821282.025.325.3Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
305912821282.058.758.7A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
306012821282.036.136.1Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
306138441281.395.531.8Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
306225621281.067.333.6Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
306325611280.571.035.5Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundstrom, K NilssonInt J Cancer1976178611Yes
306425611280.513.56.8Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J TODARO, H GREENJ Cell Biol196313985244Yes
306525611280.565.432.7A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
306625601280.049.024.5Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
306712801280.037.837.8Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
306825601280.082.141.0Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
306912801280.024.924.9Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
307012801280.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KALCKARJ Biol Chem194720285041Yes
307112791279.061.361.3Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
307212791279.00.00.0The antidiuretic hormone and the factors which determine its release. E B VERNEYProc R Soc Lond B Biol Sci194718918876Yes
307312791279.041.341.3Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
3074127801278.0310.131.0Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
307525541277.075.037.5Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
307612771277.029.429.4Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
307712771277.031.631.6The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
307838311277.0107.735.9Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
307951071276.8144.036.0Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
308012761276.029.329.3Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
308138271275.7106.235.4Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681Yes
308238251275.0174.858.3Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
308312751275.025.825.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
308412751275.027.727.7Brain tumors. L M DeAngelisN Engl J Med200111150363No
308512751275.033.733.7The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
308612751275.040.340.3Drug transport across the blood-brain barrier. William M PardridgeJ Cereb Blood Flow Metab201222929442No
308738231274.3112.937.6Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
308838221274.092.130.7Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
3089114661274.0278.831.0Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
309025461273.057.028.5Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
309125461273.050.725.4A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
309212731273.038.138.1Determining association constants from titration experiments in supramolecular chemistry. Pall ThordarsonChem Soc Rev201121125111Yes
309325461273.054.427.2The Polycomb complex PRC2 and its mark in life. Raphael Margueron, Danny ReinbergNature201121248841No
309412721272.046.446.4Substance P. B PernowPharmacol Rev19836196797No
309512721272.030.130.1A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
309612721272.026.526.5Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
309712721272.070.370.3The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A ROSEBull World Health Organ196213974778Yes
309825441272.058.929.4Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
309925441272.082.041.0Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
310025431271.551.225.6Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
310125421271.061.930.9Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
310212711271.038.038.0Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
310325411270.575.437.7Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
310425411270.564.932.5Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
310512701270.030.230.2Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
310612701270.026.826.8r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
310725401270.057.128.6Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
310812701270.039.039.0Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
310976151269.2168.828.1Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
311012691269.020.820.8Antigen receptor tail clue. M RethNature19892927501Yes
311112691269.036.036.0Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
311212691269.031.431.4Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
311312691269.031.531.5Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
311412691269.072.972.9Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WINTERNature196214007593Yes
311525381269.073.336.6Crosstalk of reactive oxygen species and NF-κB signaling. Michael J Morgan, Zheng-gang LiuCell Res201121187859No
3116139561268.7323.929.4New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
311712681268.033.833.8Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
311825361268.069.034.5Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
311925361268.0114.557.2Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Florian R Greten, Sergei I GrivennikovImmunity201931315034No
312025351267.580.340.1Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
312188711267.3222.131.7Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
312212671267.045.845.8The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
312325341267.064.832.4Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
312412671267.027.827.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
312525341267.050.325.1NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
312676021267.0269.144.9ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos SimmerlingJ Chem Theory Comput201526574453Yes
312712661266.038.538.5The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
312825321266.058.229.1Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
312912661266.034.534.5Depression in the elderly. George S AlexopoulosLancet200515936426No
313012661266.040.440.4Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
313112651265.022.222.2Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
313225301265.072.636.3Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
313337951265.085.728.6Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
313412651265.034.134.1Rethinking schizophrenia. Thomas R InselNature201021068826No
313512651265.051.351.3Cystic fibrosis. J Stuart ElbornLancet201627140670No
313625281264.066.933.5Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
313725281264.0101.050.5The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Naatanen, T PictonPsychophysiology19873615753Yes
313825281264.065.132.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
313925281264.053.526.8Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
314025261263.052.226.1Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
314112631263.034.534.5Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
314225261263.077.638.8Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
314312631263.026.626.6Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
314412631263.025.225.2Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
314512631263.032.232.2Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
314625261263.0107.553.8Principal component analysis: a review and recent developments. Ian T Jolliffe, Jorge CadimaPhilos Trans A Math Phys Eng Sci201626953178No
314725241262.081.640.8Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
314825241262.083.942.0A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
314912621262.022.522.5Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
315012621262.032.032.0AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
315112621262.045.845.8Epidemiology and risk factors for IBD. Ashwin N AnanthakrishnanNat Rev Gastroenterol Hepatol201525732745No
315288281261.1251.535.9pROC: an open-source package for R and S+ to analyze and compare ROC curves. Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus MullerBMC Bioinformatics201121414208Yes
315312611261.021.421.4Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
315412611261.025.725.7Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
315525211260.557.628.8Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
315625211260.552.026.0Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
315712601260.039.239.2Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
315812601260.024.524.5Searching for genetic determinants in the new millennium. N J RischNature200010866211No
315912601260.034.934.9High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
316050391259.8115.728.9Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
316125191259.569.634.8Mitochondria: in sickness and in health. Jodi Nunnari, Anu SuomalainenCell201222424226No
316225181259.048.024.0Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
316312591259.027.927.9Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
316412591259.035.935.9Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
316525161258.076.638.3Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
316612581258.025.625.6SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
316712581258.026.926.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
316812581258.026.626.6Human papillomavirus and cervical cancer. Eileen M BurdClin Microbiol Rev200312525422No
316925151257.557.128.6ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
317050291257.2131.532.9Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Madler, Ning LiScience200616456071No
317112571257.039.939.9Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
317212571257.029.529.5Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
317312561256.020.420.4Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
317412561256.023.923.9A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
317525121256.050.225.1TM-align: a protein structure alignment algorithm based on the TM-score. Yang Zhang, Jeffrey SkolnickNucleic Acids Res200515849316Yes
317625111255.591.445.7The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
317762771255.4291.758.3Using the framework method for the analysis of qualitative data in multi-disciplinary health research. Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi RedwoodBMC Med Res Methodol201324047204Yes
317825101255.068.534.2Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
317912551255.031.331.3Apoptosis. J J CohenImmunol Today19938466628No
318037651255.0113.737.9PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
318125101255.049.724.9Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
318212541254.042.042.0Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
318325081254.060.830.4Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
318412531253.030.830.8Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
318512531253.025.525.5Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
318612531253.032.032.0Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
318712531253.00.00.0A modification of receptor theory. R P STEPHENSONBr J Pharmacol Chemother195613383117Yes
318812531253.031.931.9A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
318912531253.024.824.8Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
319025051252.557.628.8DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
319112521252.036.336.3Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
319212521252.049.349.3The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
319312521252.030.230.2Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
319412521252.033.533.5MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
319525041252.065.132.5Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
319637541251.390.930.3The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
319712511251.047.847.8A simple method for determination of serum catalase activity and revision of reference range. L GothClin Chim Acta19912029780Yes
319812511251.022.822.8Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
319912511251.024.624.6STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
320012511251.026.326.3Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
320125021251.069.734.9Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
320212501250.033.933.9Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
320312501250.060.460.4Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
320412501250.031.631.6Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
320512501250.026.426.4How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
320612501250.033.233.2Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
320762461249.2236.747.3Frailty in elderly people. Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth RockwoodLancet201323395245No
320812491249.032.432.4Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
320912491249.022.522.5Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
321012491249.025.225.2Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
321112481248.044.344.3Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
321212481248.035.535.5A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
321312481248.035.635.6Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
321412481248.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MEDAWARBr J Exp Pathol194818865105Yes
321512471247.046.546.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
321624941247.048.324.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
321712471247.024.624.6Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
321824941247.062.731.4Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
321974821247.0161.526.9Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
322024941247.068.734.4Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
322124931246.596.748.4Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
322224921246.066.033.0Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
322312461246.062.562.5Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
322412461246.027.327.3Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
322512461246.00.00.0Sequential tests for the detection of linkage. N E MORTONAm J Hum Genet195513258560Yes
322624921246.052.226.1Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
322737381246.087.429.1Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
322837371245.7105.135.0SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stephane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
322924911245.576.838.4Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
323087161245.1263.637.7Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
323124901245.052.526.2Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
323212451245.030.130.1Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
323312441244.045.145.1Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
323412441244.029.129.1Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
323512431243.041.941.9How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
323624861243.048.024.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
323712431243.024.724.7Searching for intellectual turning points: progressive knowledge domain visualization. Chaomei ChenProc Natl Acad Sci U S A200414724295Yes
323812431243.027.327.3Viruses in the sea. Curtis A SuttleNature200516163346No
323937281242.796.232.1Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
324024851242.561.030.5Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
324112421242.015.715.7The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
324224841242.063.831.9Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
324312421242.039.839.8Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
324412421242.025.825.8The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
324524821241.0118.159.0Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
324612411241.028.628.6ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
324712401240.053.653.6Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
324812401240.015.415.4Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M VAN ROSSUMArch Int Pharmacodyn Ther196313996119Yes
324912401240.045.845.8Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
325012391239.032.132.1Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
325124781239.053.226.6The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N AMES, D T DUBINJ Biol Chem196013793161Yes
325212391239.023.423.4Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
325361921238.4191.338.3Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
325424761238.067.633.8Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
325512381238.055.455.4Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
325612381238.036.536.5Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
325712381238.028.128.1Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
325824751237.5102.551.2Designing hydrogels for controlled drug delivery. Jianyu Li, David J MooneyNat Rev Mater201629657852Yes
325912371237.022.322.3Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
326012371237.030.530.5An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
326174181236.3135.022.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
326212361236.045.845.8Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
326312361236.034.734.7The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
326412361236.023.123.1Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
326512361236.036.836.8Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
326612361236.030.530.5Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
326724711235.572.036.0The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
326824711235.5105.552.8The role of inflammation in depression: from evolutionary imperative to modern treatment target. Andrew H Miller, Charles L RaisonNat Rev Immunol201626711676No
326912351235.036.836.8MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
327061741234.8112.622.5The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
327124691234.539.319.6A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
327224681234.090.945.5Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
327312341234.036.036.0The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
327412341234.020.920.9Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
327524671233.550.025.0Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
327637001233.373.924.6Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
327712331233.025.325.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
327861631232.6204.640.9Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
327912321232.024.724.7Evolution of ageing. T B KirkwoodNature1977593350Yes
328012321232.037.437.4Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
328112321232.030.130.1Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
328212321232.025.125.1Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
328324621231.089.644.8Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
328412311231.027.327.3Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
328512311231.026.526.5Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
328624611230.552.026.0Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
328712301230.033.933.9Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
328812301230.025.725.7Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
328912301230.021.221.2NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
329073781229.7275.645.9GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin ZhangNucleic Acids Res201728407145Yes
329136881229.371.123.7SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
329212291229.058.658.6The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
329312291229.031.931.9Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
329412291229.029.229.2Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
329512291229.039.139.1Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
329624571228.563.231.6Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
329724561228.083.641.8A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
329812281228.025.125.1MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
329912281228.031.731.7Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
330061361227.2164.432.9Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
330112271227.028.428.4Growth factors and cancer. S A AaronsonScience19911659742No
330212271227.024.124.1The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. P StothardBiotechniques200010868275Yes
330324541227.067.333.6Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
330412271227.049.749.7Mediation Analysis: A Practitioner's Guide. Tyler J VanderWeeleAnnu Rev Public Health201626653405No
330524531226.553.626.8Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
330624531226.569.034.5Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
330798121226.5435.154.4Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K ChandaNat Commun201930944313Yes
330824521226.0189.794.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
330912261226.033.633.6Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
331012261226.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BUONOCOREJ Dent Res195513271655Yes
331112251225.022.122.1Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
331212251225.030.430.4Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
331312251225.026.726.7Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
331412251225.031.231.2The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
331512251225.028.928.9Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
331612251225.033.033.0Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
331748981224.5258.764.7Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. Shaoqing Ren, Kaiming He, Ross Girshick, Jian SunIEEE Trans Pattern Anal Mach Intell201727295650Yes
331812241224.029.229.2Identifying and characterizing binding sites and assessing druggability. Thomas A HalgrenJ Chem Inf Model200919434839Yes
331912231223.056.856.8Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
332012231223.058.658.6ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
332112231223.074.174.1Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
332212231223.023.723.7Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
332312221222.025.725.7Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
332424441222.048.624.3The mammalian unfolded protein response. Martin Schroder, Randal J KaufmanAnnu Rev Biochem200515952902No
332524441222.057.028.5Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. In Suk Joung, Thomas E CheathamJ Phys Chem B200818593145Yes
332612221222.033.333.3Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
332736651221.7103.034.3A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
332836651221.760.320.1A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, Rene Bernards, Reuven AgamiScience200211910072Yes
332924431221.581.540.8Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
333024431221.554.727.4The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
333124431221.572.336.1Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
333224431221.588.744.4Comparative Protein Structure Modeling Using MODELLER. Benjamin Webb, Andrej SaliCurr Protoc Bioinformatics201627322406Yes
333312211221.025.025.0Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
333412211221.023.723.7Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
333512211221.022.622.6IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
333612211221.037.537.5The inflammatory response in myocardial injury, repair, and remodelling. Nikolaos G FrangogiannisNat Rev Cardiol201424663091No
333736621220.7111.537.2Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
333824411220.571.535.8Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
333936611220.3101.833.9Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
334012201220.040.640.6The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
334112201220.023.523.5Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
334212201220.032.932.9Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
334324401220.065.832.9Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Marie Cargnello, Philippe P RouxMicrobiol Mol Biol Rev201121372320No
334412201220.052.652.6Review of the psychometric evidence of the perceived stress scale. Eun-Hyun LeeAsian Nurs Res (Korean Soc Nurs Sci)201225031113Yes
334536591219.791.930.6Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
334624391219.580.940.5Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
334724381219.082.341.1The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
334824381219.054.027.0Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
334912191219.028.228.2The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
335012191219.028.028.0Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
335112191219.00.00.0Voluntary strength and fatigue. P A MERTONJ Physiol195413152698Yes
335212191219.034.634.6pegas: an R package for population genetics with an integrated-modular approach. Emmanuel ParadisBioinformatics201020080509Yes
335312191219.041.341.3Human milk oligosaccharides: every baby needs a sugar mama. Lars BodeGlycobiology201222513036No
335424381219.089.844.9Tumour heterogeneity and resistance to cancer therapies. Ibiayi Dagogo-Jack, Alice T ShawNat Rev Clin Oncol201829115304No
335548741218.5139.134.8Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
335624371218.526.113.1The Aggregation Of Blood Platelets. G V BORN, M J CROSSJ Physiol196314056485Yes
335773111218.5162.527.1Enzymatic assembly of DNA molecules up to several hundred kilobases. Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O SmithNat Methods200919363495Yes
335824341217.063.931.9Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
335912171217.025.925.9Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
336036501216.772.324.1Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
336136491216.374.324.85-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
336212161216.029.129.1Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
336312161216.042.842.8Type 2 inflammation in asthma--present in most, absent in many. John V FahyNat Rev Immunol201525534623No
336412151215.033.333.3What is synergy? M C BerenbaumPharmacol Rev19892692037No
336512151215.0108.5108.5The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
336624301215.087.843.9Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
336712151215.024.324.3Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
336812151215.032.532.5Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
336912151215.047.147.1Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
337024291214.561.130.6Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
337112141214.030.230.2Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsakiNeuroscience19892687720No
337212141214.048.348.3Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
337312141214.032.732.7Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
337436421214.0127.042.3Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Dmitry B Zorov, Magdalena Juhaszova, Steven J SollottPhysiol Rev201424987008No
337536411213.793.531.2Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
337624271213.534.917.4High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
337724271213.557.428.7Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
337824271213.552.426.2microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
337924251212.567.533.8Regulation of type I interferon responses. Lionel B Ivashkiv, Laura T DonlinNat Rev Immunol201424362405No
338012121212.026.326.3Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
338112121212.030.230.2Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
338296961212.0295.536.9Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S MarksAm J Prev Med19989635069Yes
338312121212.029.029.0The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
338412121212.034.734.7The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. John DuncanTrends Cogn Sci201020171926No
338524231211.564.232.1Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
338624231211.593.546.8Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Michael A Gimbrone, Guillermo Garcia-CardenaCirc Res201626892962No
338724221211.0104.552.2Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
338812111211.027.927.9Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
338912111211.031.931.9What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
339036331211.095.131.7FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Morgan N Price, Paramvir S Dehal, Adam P ArkinMol Biol Evol200919377059Yes
3391121081210.8388.638.9The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
339212101210.052.252.2Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
339312101210.022.622.6Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
339448371209.290.622.6Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
339512091209.050.350.3A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
339612091209.063.263.2A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
339724181209.061.830.9Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
339824181209.068.334.1Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
339912091209.033.233.2ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
340036271209.0141.747.2Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Antonio Ayala, Mario F Munoz, Sandro ArguellesOxid Med Cell Longev201424999379No
340112081208.075.175.1Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
340236241208.0126.142.0Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
340324161208.042.421.2Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
340424161208.0192.796.3Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
340512071207.035.935.9The mysteries of lipoprotein(a). G UtermannScience19892530631No
340612071207.038.438.4Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
340712071207.029.729.7The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
340824131206.559.029.5Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
340936191206.3121.040.3Ecological momentary assessment. Saul Shiffman, Arthur A Stone, Michael R HuffordAnnu Rev Clin Psychol200818509902No
341012061206.037.837.8The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
341112061206.025.425.4The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
341212061206.017.417.4The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E HOPE-SIMPSONProc R Soc Med196514267505Yes
341336171205.780.126.7Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
341436171205.7229.376.4How to perform a meta-analysis with R: a practical tutorial. Sara Balduzzi, Gerta Rucker, Guido SchwarzerEvid Based Ment Health201931563865Yes
341524111205.545.822.9Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
341612051205.026.526.5The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
341712051205.041.241.2Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
341812051205.018.518.5Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
341912051205.019.219.2Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
342012051205.031.531.5Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532Yes
342112051205.025.325.3Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
342224101205.068.834.4The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
342324091204.587.743.9Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
342424091204.552.726.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
342524091204.551.925.9Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
342612041204.030.830.8Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
342724081204.057.128.6The regulation of IL-10 production by immune cells. Margarida Saraiva, Anne O'GarraNat Rev Immunol201020154735No
342812031203.049.049.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
342912031203.042.042.0Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
343036081202.781.127.0Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernan, B BrumbackEpidemiology200010955408Yes
343172131202.2171.228.5Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, Lancet200212493255Yes
343212021202.029.729.7Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
343312021202.033.533.56-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
343424041202.050.225.1Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
343512021202.032.232.2On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
343660071201.4140.828.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
343736041201.391.530.5Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
343836041201.3109.936.6The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
343924021201.097.148.5Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
344012011201.032.732.7The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
344112011201.029.529.5Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
344224011200.568.534.2Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
344324011200.577.338.6Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
344424011200.552.826.4Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794Yes
3445132051200.5243.522.1Model-based analysis of ChIP-Seq (MACS). Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley LiuGenome Biol200818798982Yes
344612001200.036.636.6Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
344712001200.021.321.3Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
344872001200.0243.940.6The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
344912001200.020.420.4Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
345012001200.029.729.7Optogenetics. Karl DeisserothNat Methods201121191368Yes
345135991199.7166.455.5Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
345235991199.785.628.5Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
345323991199.5122.661.3The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
345423991199.576.038.0Toll-like receptor signaling pathways. Takumi Kawasaki, Taro KawaiFront Immunol201425309543No
345523971198.548.124.1Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
345623971198.543.521.8The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
345723971198.544.122.1Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
345823971198.567.934.0Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
3459107841198.2351.939.1A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
346011981198.010.010.0A New Serum Type System In Man--The Lp System. K BERGActa Pathol Microbiol Scand196314064818Yes
346111981198.050.450.4Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Daniel J DruckerCell Metab201829617641No
346235921197.371.723.9Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
346311971197.028.328.3Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
346411971197.037.737.7Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
346511971197.039.539.5beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
346611971197.026.626.6The columnar organization of the neocortex. V B MountcastleBrain19979153131No
346735911197.0119.039.7Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
346823931196.569.834.9Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
346947851196.2106.626.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
347011961196.040.040.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
347123921196.048.124.1Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
347283661195.1160.122.9Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
347311951195.045.145.1Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
347411951195.027.527.5Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
347511951195.025.125.1G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
347623901195.049.024.5Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
347723881194.046.223.1Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
347811941194.058.258.2Osseointegration and its experimental background. P I BranemarkJ Prosthet Dent19836352924No
347911941194.044.144.1Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
348011941194.033.733.7Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
348111941194.022.822.8Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
348259681193.6210.342.1Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
3483119321193.2262.826.3Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus SchultenJ Comput Chem200516222654Yes
348411931193.037.237.2Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan St B T EvansAnnu Rev Psychol200818154502No
348511931193.053.153.1Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
348671571192.8150.025.0Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
348723851192.5104.952.5Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
348823851192.549.624.8Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
348923851192.556.628.3Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
349047681192.0114.228.6Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
349111921192.023.523.5The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DUNCOMBEClin Chim Acta196414122498Yes
349223831191.556.328.1Interaction revisited: the difference between two estimates. Douglas G Altman, J Martin BlandBMJ200312543843No
349311911191.068.368.3Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
349411911191.030.830.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
349523821191.095.447.7Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
349611911191.036.336.3Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
349711911191.028.228.2Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" F D HaldanePhys Rev Lett198810038961Yes
349823821191.052.426.2Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
349911911191.029.129.1Overview of the immune response. David D ChaplinJ Allergy Clin Immunol201020176265No
350011911191.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
350111901190.033.933.9Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
350223801190.037.518.8Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
350311901190.023.023.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B ASHWORTHPractitioner196414143329Yes
350423801190.050.125.1Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
350511901190.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C CHANGNature195114882325Yes
350623801190.055.927.9Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
350747601190.0122.830.7Gene ontology analysis for RNA-seq: accounting for selection bias. Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia OshlackGenome Biol201020132535Yes
350811901190.033.133.1Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Masabumi ShibuyaGenes Cancer201122866201Yes
350923791189.594.547.2Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. T J Cole, T LobsteinPediatr Obes201222715120Yes
351023791189.598.249.1Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Douglas J Morrison, Tom PrestonGut Microbes201626963409No
351123781189.051.725.9Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
351211891189.020.820.8Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
351311891189.022.022.0Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
351411891189.031.931.9Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
351511891189.044.444.4The angular gyrus: multiple functions and multiple subdivisions. Mohamed L SeghierNeuroscientist201322547530No
351623781189.073.836.9Infernal 1.1: 100-fold faster RNA homology searches. Eric P Nawrocki, Sean R EddyBioinformatics201324008419Yes
351723771188.591.245.6Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Jerome Galon, Daniela BruniNat Rev Drug Discov201930610226No
351835641188.0179.359.8Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
351923761188.091.445.7Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. N L Glass, G C DonaldsonAppl Environ Microbiol19957747954Yes
352011881188.032.032.0Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
352111881188.032.632.6On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
352223761188.050.425.2Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
3523166251187.5350.325.0Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
352423751187.563.631.8Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
352511871187.062.462.4The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
352611871187.027.127.1Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
352711871187.030.830.8A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
352811871187.040.040.0DREADDs for Neuroscientists. Bryan L RothNeuron201626889809No
352959331186.6191.038.2Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
353023731186.574.737.4Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
353123721186.0110.755.4Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
353211861186.011.411.4Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
353347411185.2109.227.3Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
353411851185.034.534.5On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
353511851185.033.433.4Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
353611851185.039.239.2What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
353735541184.7119.539.8Social relationships and mortality risk: a meta-analytic review. Julianne Holt-Lunstad, Timothy B Smith, J Bradley LaytonPLoS Med201020668659No
353835531184.393.231.1A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
353911841184.038.838.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
354035521184.075.725.2Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
354111841184.030.030.0The quantum internet. H J KimbleNature200818563153Yes
354211841184.038.138.1Epidemiology of heart failure. Veronique L RogerCirc Res201323989710No
354311841184.033.233.2Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Rakesh K JainCancer Cell201425517747No
354423671183.549.424.7Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
354523671183.564.132.0Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
354623661183.047.523.8The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
354711831183.022.022.0VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
354847311182.8121.030.2Mussel-inspired surface chemistry for multifunctional coatings. Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B MessersmithScience200717947576Yes
354911821182.056.256.2The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
355011821182.043.843.8Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
355111821182.029.229.2Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
355211821182.026.426.4Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
355311821182.030.930.9Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
355411821182.044.244.2Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). F BerenbaumOsteoarthritis Cartilage201323194896No
355535451181.770.623.5Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
355623631181.573.136.5Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
355723631181.577.338.6The gut microbiota--masters of host development and physiology. Felix Sommer, Fredrik BackhedNat Rev Microbiol201323435359No
355823621181.064.432.2The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
355923621181.072.836.4Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
356011811181.026.726.7Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
356111811181.040.240.2Considerations in determining sample size for pilot studies. Melody A HertzogRes Nurs Health200818183564No
356223611180.539.719.9A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
356323611180.551.225.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
356411801180.034.734.7Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
356523601180.042.821.4Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
356611801180.026.926.9Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
356711791179.039.139.1Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
356811791179.036.736.7Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
356923581179.057.828.9Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
357011791179.028.628.6Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
357123581179.063.731.9Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
357211791179.034.034.0Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BunzliChem Rev201020151630No
357323571178.584.842.4The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
357411781178.036.936.9Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
357511781178.030.630.6Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
357611781178.034.934.9Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
357711781178.024.224.2Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
357835331177.796.232.1Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
357923541177.094.647.3A real-time QRS detection algorithm. J Pan, W J TompkinsIEEE Trans Biomed Eng19853997178Yes
358011771177.030.630.6Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
358111771177.029.129.1Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
358211771177.021.321.3The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
358335311177.074.524.8Population structure and eigenanalysis. Nick Patterson, Alkes L Price, David ReichPLoS Genet200617194218Yes
358411771177.023.823.8Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
358511771177.023.223.2Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
358611771177.030.130.1Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
358723541177.089.644.8The Human Intestinal Microbiome in Health and Disease. Susan V Lynch, Oluf PedersenN Engl J Med201627974040No
358823531176.556.228.1The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
358923531176.586.943.5OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. David M Emms, Steven KellyGenome Biol201526243257Yes
359011761176.052.752.7Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
359123521176.077.038.5Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
359211761176.00.00.0The powerful placebo. H K BEECHERJ Am Med Assoc195513271123Yes
359311761176.034.534.5Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
359411761176.026.326.3Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
359511751175.052.952.9Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
359611751175.028.228.2Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
359711751175.030.430.4Inflammation 2010: new adventures of an old flame. Ruslan MedzhitovCell201020303867No
359823491174.580.840.4ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Tauno Metsalu, Jaak ViloNucleic Acids Res201525969447Yes
359911741174.051.851.8Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
360011741174.025.825.8Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
360111741174.034.634.6The mental health continuum: from languishing to flourishing in life. Corey L M KeyesJ Health Soc Behav200212096700Yes
360211741174.030.230.2Neural stimulation and recording electrodes. Stuart F CoganAnnu Rev Biomed Eng200818429704No
360335211173.7176.358.8Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Yan Zheng, Sylvia H Ley, Frank B HuNat Rev Endocrinol201829219149No
360411731173.034.234.2Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
360511731173.033.333.3Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
360635191173.0105.835.3Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Irith Wiegand, Kai Hilpert, Robert E W HancockNat Protoc200818274517Yes
360723461173.050.525.2Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
360823461173.085.142.5MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Martin Steinegger, Johannes SodingNat Biotechnol201729035372Yes
360935171172.389.829.9Fluorine in pharmaceuticals: looking beyond intuition. Klaus Muller, Christoph Faeh, Francois DiederichScience200717901324No
361011721172.026.126.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
361111721172.031.831.8Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
361223441172.043.321.6NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
361311721172.025.925.9Sjögren's syndrome. Robert I FoxLancet200516039337No
361411721172.026.926.9Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Andrey A ShabalinBioinformatics201222492648Yes
361511721172.054.154.1A decade of immune-checkpoint inhibitors in cancer therapy. Caroline RobertNat Commun202032732879Yes
361658591171.8232.546.5KEGG: new perspectives on genomes, pathways, diseases and drugs. Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae MorishimaNucleic Acids Res201727899662Yes
361723431171.566.933.5Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
361811711171.039.439.4Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
361911711171.024.324.3Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
362011711171.024.124.1Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
362111711171.031.931.9The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
362211711171.042.242.2Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Georgia SalantiRes Synth Methods201226062083Yes
362335101170.0141.047.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
362411701170.034.934.9Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
362511701170.011.611.6Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
362611701170.033.633.6Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
362723401170.056.828.4Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Sophia Y Lunt, Matthew G Vander HeidenAnnu Rev Cell Dev Biol201121985671No
362811691169.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B REXEDJ Comp Neurol195214946260Yes
362911691169.025.725.7Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
363011691169.040.940.9Autonomic nervous system activity in emotion: a review. Sylvia D KreibigBiol Psychol201020371374No
363111691169.035.435.4The Danish Cancer Registry. Marianne Lundkjaer GjerstorffScand J Public Health201121775350Yes
363223361168.049.224.6Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
363335031167.7112.737.6The Danish National Patient Register. Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka ReboljScand J Public Health201121775347Yes
363423351167.558.529.2Cancer epigenetics: from mechanism to therapy. Mark A Dawson, Tony KouzaridesCell201222770212No
363511671167.027.727.7Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. R ZahorecBratisl Lek Listy200111723675Yes
363635001166.780.426.8Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Vinuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
363711661166.042.542.5Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
363811661166.032.332.3Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. J C MorrisInt Psychogeriatr19979447441Yes
363911661166.031.331.3Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
364011661166.00.00.0Knee joint changes after meniscectomy. T J FAIRBANKJ Bone Joint Surg Br194818894618Yes
364158281165.6113.422.7Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
364223311165.560.730.4The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Maria M Mihaylova, Reuben J ShawNat Cell Biol201121892142No
364311651165.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BROWNBiochem J195514389222Yes
364411651165.028.628.6Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
364534941164.7172.157.4Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Mojtaba Vaismoradi, Hannele Turunen, Terese BondasNurs Health Sci201323480423No
364611641164.024.524.5Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
364711641164.035.135.1Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
364811641164.026.626.6Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
364911641164.031.431.4Leishmaniasis. B L HerwaldtLancet199910513726No
365011641164.029.529.5The complex world of WNT receptor signalling. Christof NiehrsNat Rev Mol Cell Biol201223151663No
365111631163.020.620.6Biogenic amines and the states of sleep. M JouvetScience19694303225No
365211631163.030.430.4Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
365311631163.026.126.1The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
365411631163.021.621.6The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
365511631163.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BULBRINGBr J Pharmacol Chemother194620999334Yes
365611631163.057.657.6Resin composite--state of the art. Jack L FerracaneDent Mater201121093034No
365711631163.045.345.3Vitamin D metabolism, mechanism of action, and clinical applications. Daniel D BikleChem Biol201424529992No
365823241162.046.923.4Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
365911621162.020.420.4DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
366011621162.034.934.9Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
366111621162.030.830.8Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Barry HalliwellPlant Physiol200616760481Yes
366211621162.034.634.6Chronic stress, drug use, and vulnerability to addiction. Rajita SinhaAnn N Y Acad Sci200818991954No
366381311161.6532.876.1IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert LanfearMol Biol Evol202032011700Yes
366434841161.399.233.1Macrophage biology in development, homeostasis and disease. Thomas A Wynn, Ajay Chawla, Jeffrey W PollardNature201323619691No
366511611161.032.032.0Cyclin-dependent kinases. Marcos MalumbresGenome Biol201425180339No
366611611161.043.343.3A polarizing question: do M1 and M2 microglia exist? Richard M RansohoffNat Neurosci201627459405No
366711611161.057.957.9Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Hector F Escobar-MorrealeNat Rev Endocrinol201829569621No
366823211160.566.733.4Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
366911601160.033.633.6Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
367011601160.024.224.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
367123201160.062.131.1The diversity and biogeography of soil bacterial communities. Noah Fierer, Robert B JacksonProc Natl Acad Sci U S A200616407148Yes
367211601160.042.842.8Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. Walter S LealAnnu Rev Entomol201323020622No
367323191159.559.029.5Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
367423191159.5100.150.0Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Luigi Ferrucci, Elisa FabbriNat Rev Cardiol201830065258No
367523181159.069.234.6Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
367611591159.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VAGUEAm J Clin Nutr195613282851Yes
367711591159.039.439.4The pain self-efficacy questionnaire: Taking pain into account. Michael K NicholasEur J Pain200716446108Yes
367811591159.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
367923171158.5131.665.8Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W BUTCHER, E W SUTHERLANDJ Biol Chem196213875173Yes
368034751158.3135.345.1Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
368111581158.027.227.2Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
368211581158.033.633.6Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
368334731157.7134.144.7The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris BoshoffNature201829364287No
368423151157.561.130.6The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
368523151157.584.542.2Gut microbiota, metabolites and host immunity. Michelle G Rooks, Wendy S GarrettNat Rev Immunol201627231050No
368623141157.058.829.4Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
368711571157.037.437.4Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
368811571157.021.221.2The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
368934691156.383.727.9High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
369011561156.024.324.3RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
369111561156.028.228.2Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
369223121156.049.224.6Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
369311561156.022.022.0Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
369411561156.038.838.8Constructive and unconstructive repetitive thought. Edward R WatkinsPsychol Bull200818298268No
369511561156.035.135.1Staphylococcus epidermidis--the 'accidental' pathogen. Michael OttoNat Rev Microbiol200919609257No
369611561156.038.638.6The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Peter C AustinStat Med201424122911Yes
369723111155.570.235.1Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
369834651155.072.724.2A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
369911551155.041.441.4Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
370011551155.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VANEBr J Pharmacol Chemother195713460242Yes
370169281154.7177.929.7Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
370223091154.596.548.2The Tumor Microenvironment Innately Modulates Cancer Progression. Dominique C Hinshaw, Lalita A ShevdeCancer Res201931350295No
370311541154.030.930.9Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
370411541154.029.529.5Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
370511541154.021.921.9Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
370611541154.045.145.1Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Laura J JulianArthritis Care Res (Hoboken)201122588767No
370711541154.027.727.7Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
370823071153.550.625.3Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
370923071153.556.528.2Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
371034601153.398.132.7AMPK: a nutrient and energy sensor that maintains energy homeostasis. D Grahame Hardie, Fiona A Ross, Simon A HawleyNat Rev Mol Cell Biol201222436748No
371146121153.0205.451.4An ecological perspective on health promotion programs. K R McLeroy, D Bibeau, A Steckler, K GlanzHealth Educ Q19883068205No
371223061153.066.733.4Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
371323061153.049.924.9Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
371411531153.029.129.1Gibberellin metabolism and its regulation. Shinjiro YamaguchiAnnu Rev Plant Biol200818173378No
371511531153.031.931.9Normal bone anatomy and physiology. Bart ClarkeClin J Am Soc Nephrol200818988698No
371623061153.089.344.6Shared decision making--pinnacle of patient-centered care. Michael J Barry, Susan Edgman-LevitanN Engl J Med201222375967Yes
371723051152.546.023.0A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
371823051152.560.430.2Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
371911521152.019.119.1Evolution and tinkering. F JacobScience1977860134Yes
372023041152.076.738.4Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudasN Engl J Med19921307234Yes
372111521152.020.920.9Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
372211521152.031.831.8Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
372323041152.058.729.4Molecular mechanisms of T cell co-stimulation and co-inhibition. Lieping Chen, Dallas B FliesNat Rev Immunol201323470321No
372446071151.8107.526.9C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
372523031151.548.524.2Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
372623031151.578.639.3Superoxide dismutases: I. Occurrence in higher plants. C N Giannopolitis, S K RiesPlant Physiol197716659839Yes
372723031151.557.228.6Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NunezNat Rev Immunol201021088683No
372811511151.024.024.0Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
372980541150.6553.479.1TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui XiaMol Plant202032585190Yes
373023011150.553.226.6Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
373134511150.368.222.7Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Juri Rappsilber, Matthias Mann, Yasushi IshihamaNat Protoc200717703201Yes
373211501150.032.432.4Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
373311501150.023.223.2Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
373411501150.021.821.8Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
373511501150.032.032.0Cellular and molecular mechanisms of renal fibrosis. Youhua LiuNat Rev Nephrol201122009250No
373622991149.546.723.4Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
373711491149.032.032.0DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
373811491149.023.923.9Stem cells in the central nervous system. R McKayScience19979082987No
373922981149.045.122.6Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
374011491149.030.430.4A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
374111491149.024.524.5Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
374222971148.555.327.6An improved general amino acid replacement matrix. Si Quang Le, Olivier GascuelMol Biol Evol200818367465Yes
374334451148.3100.633.5Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
374468891148.2173.628.9The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
374522961148.044.522.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
374611481148.034.334.3Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
374711481148.042.042.0View through a window may influence recovery from surgery. R S UlrichScience19846143402Yes
374811481148.028.628.6Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
374911481148.020.520.5Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
375011481148.022.822.8Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
375111481148.00.00.0A new microscopic principle. D GABORNature194818860291Yes
375211481148.033.633.6Graves' ophthalmopathy. Rebecca S BahnN Engl J Med201020181974No
375311471147.021.521.5Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
375411471147.021.721.7Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
375534411147.087.729.2Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
375611471147.020.220.2The development of neural stem cells. S TempleNature200111689956No
375722941147.049.924.9Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Sharon R Browning, Brian L BrowningAm J Hum Genet200717924348Yes
375811471147.033.133.1Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
375945871146.8109.627.4Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
376045851146.2145.936.5The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
376111461146.044.844.8Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
376211461146.031.131.1Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
376311461146.033.133.1Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
376411461146.027.027.0Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
376557301146.0259.451.9VSEARCH: a versatile open source tool for metagenomics. Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic MahePeerJ201627781170Yes
376622911145.545.722.9Fcgamma receptors as regulators of immune responses. Falk Nimmerjahn, Jeffrey V RavetchNat Rev Immunol200818064051No
376722901145.059.229.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
376811451145.026.126.1Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
376911451145.028.928.9Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
377011451145.024.124.1Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
3771183201145.0675.842.2SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A PevznerJ Comput Biol201222506599Yes
377222891144.541.020.5AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
377322891144.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H USSING, K ZERAHNActa Physiol Scand195114868510Yes
377422881144.00.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C TRUELOVE, L J WITTSBr Med J195513260656Yes
377522871143.572.736.4Positive psychology. An introduction. M E Seligman, M CsikszentmihalyiAm Psychol200011392865Yes
377645741143.534.08.5The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLMELancet196313990765Yes
377711431143.043.643.6Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
377811431143.028.628.6Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
377934291143.090.930.3Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
378011431143.031.931.9An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
378111431143.032.132.1Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
378211431143.037.937.9A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
378322861143.056.828.4Monocyte recruitment during infection and inflammation. Chao Shi, Eric G PamerNat Rev Immunol201121984070No
378434271142.3111.037.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
378511421142.026.126.1BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
378622841142.045.222.6A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
378722841142.055.927.9The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Laetitia Prut, Catherine BelzungEur J Pharmacol200312600700No
378811421142.027.027.0Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
378922841142.063.031.5ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
379057101142.0162.732.5Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G AltmanPLoS Biol201020613859No
379168481141.3186.131.0Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
379234241141.376.625.5STATs in cancer inflammation and immunity: a leading role for STAT3. Hua Yu, Drew Pardoll, Richard JoveNat Rev Cancer200919851315No
379311411141.033.833.8Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
379411411141.040.540.5Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
379511411141.043.943.9Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
379611411141.017.017.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EGEBERGThromb Diath Haemorrh196514347873Yes
379711411141.067.967.9Diffusion-in-gel methods for immunological analysis. II. O OUCHTERLONYProg Allergy196214482809Yes
379811411141.032.332.3Targeting the DNA Damage Response in Cancer. Mark J O'ConnorMol Cell201526590714No
379911411141.054.854.8The expanding regulatory mechanisms and cellular functions of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol202032366901No
380022801140.063.331.6Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
380111401140.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HOTCHKISSArch Biochem194818921848Yes
380211401140.043.543.5A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
3803125341139.5413.637.6A global reference for human genetic variation. , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R AbecasisNature201526432245Yes
380411391139.031.131.1Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. A E BlackInt J Obes Relat Metab Disord200011033980Yes
380511391139.023.723.7Complement. Second of two parts. M J WalportN Engl J Med200111297706No
380622781139.084.842.4Epidemiology of adult fractures: A review. Charles M Court-Brown, Ben CaesarInjury200616814787No
380711391139.022.922.9Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
380822781139.047.223.6Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Javier A Menendez, Ruth LupuNat Rev Cancer200717882277No
380911391139.044.044.0Reference methods for the assessment of physical characteristics of meat. K O HonikelMeat Sci199822060626Yes
381045531138.2172.543.1The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. L B Krupp, N G LaRocca, J Muir-Nash, A D SteinbergArch Neurol19892803071Yes
381122761138.072.336.1Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
381211381138.036.536.5Subjective well-being. The science of happiness and a proposal for a national index. E DienerAm Psychol200011392863Yes
381322761138.051.125.6Efficient behavior of small-world networks. V Latora, M MarchioriPhys Rev Lett200111690461Yes
381411381138.016.716.7Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PENNINGTONBiochem J196113734134Yes
381511381138.024.124.1Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
381622751137.586.543.2Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Marta Kutas, Kara D FedermeierAnnu Rev Psychol201120809790No
381711371137.040.040.0Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
381811371137.029.429.4Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
381911371137.026.526.5Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
382022731136.590.745.4Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
382122731136.559.329.6Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassagueJ Biol Chem19863456347Yes
382222721136.090.945.5The aggression questionnaire. A H Buss, M PerryJ Pers Soc Psychol19921403624Yes
382322721136.085.142.5Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
382411361136.020.420.4Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
382545441136.0103.926.0SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
382611361136.025.925.9Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
382734071135.780.626.9Pathogenic Escherichia coli. James B Kaper, James P Nataro, Harry L MobleyNat Rev Microbiol200415040260No
382811351135.027.027.0Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
382911351135.025.925.9Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
383011351135.025.025.0What is principal component analysis? Markus RingnerNat Biotechnol200818327243Yes
383111351135.00.00.0pA, a new scale for the measurement of drug antagonism. H O SCHILDBr J Pharmacol Chemother194720258355Yes
383256741134.8195.239.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Open Med200921603045Yes
383311341134.034.234.2Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
383411341134.034.634.6Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
383511341134.027.527.5DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
383634021134.093.131.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
383711341134.024.924.9Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
383811341134.020.920.9Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
383911341134.029.629.6Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
384022681134.064.232.1Extended-spectrum beta-lactamases: a clinical update. David L Paterson, Robert A BonomoClin Microbiol Rev200516223952No
384111341134.034.034.0Recommended effect size statistics for repeated measures designs. Roger BakemanBehav Res Methods200516405133Yes
384211341134.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
384311341134.028.928.9Electrogenerated chemiluminescence and its biorelated applications. Wujian MiaoChem Rev200818505298No
384456691133.8180.936.2A simulation study of the number of events per variable in logistic regression analysis. P Peduzzi, J Concato, E Kemper, T R Holford, A R FeinsteinJ Clin Epidemiol19968970487Yes
384522671133.5136.668.3Modified reagents for determination of urea and ammonia. A L CHANEY, E P MARBACHClin Chem196213878063Yes
384611331133.026.726.7The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. G HardinScience19685699198Yes
384711331133.00.00.0The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. C D MurrayProc Natl Acad Sci U S A192616576980Yes
384811331133.044.544.5Root canal irrigants. Matthias ZehnderJ Endod200616631834No
384979281132.6135.319.3The human genome browser at UCSC. W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David HausslerGenome Res200212045153Yes
385011321132.069.369.3Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
385111321132.081.281.2Fibula free flap: a new method of mandible reconstruction. D A HidalgoPlast Reconstr Surg19892734406Yes
385211321132.041.841.8Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
385311321132.027.227.2The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
385422641132.040.920.4Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
385522641132.055.527.8Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
385611321132.041.441.4Surface-enhanced Raman spectroscopy: concepts and chemical applications. Sebastian SchluckerAngew Chem Int Ed Engl201424711218Yes
385711311131.034.534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
3858203581131.0483.826.9PHENIX: a comprehensive Python-based system for macromolecular structure solution. Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H ZwartActa Crystallogr D Biol Crystallogr201020124702Yes
385922611130.555.927.9A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
386033911130.364.321.4Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
386111301130.023.623.6Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
386211301130.056.256.2The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
386311301130.020.220.2Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
386411301130.042.542.5On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
386511301130.039.139.1Development of the practice environment scale of the Nursing Work Index. Eileen T LakeRes Nurs Health200212015780Yes
386611301130.031.731.7Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
386722591129.553.426.7T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
386822591129.570.235.1Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
386922591129.584.842.4Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
387022591129.5118.659.3Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. Amy J H Kind, William R BuckinghamN Engl J Med201829949490Yes
387156471129.4149.830.0A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo PandolfiCell201121802130Yes
387211291129.039.939.9Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
387311291129.028.528.5Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
387411291129.033.133.1Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
387511291129.027.327.3Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
387611291129.025.725.7Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WurthnerChem Commun (Camb)200415263926Yes
387722581129.057.928.9Cu-catalyzed azide-alkyne cycloaddition. Morten Meldal, Christian Wenzel TornoeChem Rev200818698735No
387822571128.587.443.7Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
387922571128.545.122.6RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
388045131128.297.024.2Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled ClaytonCurr Protoc Cell Biol200618228490Yes
388111281128.028.628.6Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
388211281128.018.418.4The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
388311281128.022.522.5Alpha-synuclein and neurodegenerative diseases. M GoedertNat Rev Neurosci200111433374No
388411281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B STAVITSKYJ Immunol195413163409Yes
388511281128.00.00.0The stereotaxic method and radiosurgery of the brain. L LEKSELLActa Chir Scand195114914373Yes
388611281128.037.737.7Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Murray B IsmanAnnu Rev Entomol200616332203No
388733841128.0115.638.5The weirdest people in the world? Joseph Henrich, Steven J Heine, Ara NorenzayanBehav Brain Sci201020550733Yes
388822561128.074.137.0Glycosylation in cancer: mechanisms and clinical implications. Salome S Pinho, Celso A ReisNat Rev Cancer201526289314No
388922551127.536.418.2Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
389056371127.4199.639.9A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
389111271127.027.927.9Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
389211271127.025.125.1Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
389322541127.099.849.9Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
389411271127.024.124.1The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
389511261126.021.821.8Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
389611261126.027.027.0Omega-3 fatty acids in inflammation and autoimmune diseases. Artemis P SimopoulosJ Am Coll Nutr200212480795No
389711261126.00.00.0Motivation reconsidered: the concept of competence. R W WHITEPsychol Rev195913844397Yes
389811261126.023.823.8The action potential in mammalian central neurons. Bruce P BeanNat Rev Neurosci200717514198No
389911251125.049.449.4Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
390011251125.031.231.2Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
390111251125.024.524.5Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
390211251125.032.032.0The social brain in adolescence. Sarah-Jayne BlakemoreNat Rev Neurosci200818354399No
390322491124.564.832.4Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. R J Ginsberg, L V RubinsteinAnn Thorac Surg19957677489Yes
390422491124.548.724.4Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
390522491124.552.826.4Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkBioinformatics200717050570Yes
390633731124.3133.244.4Rheumatoid arthritis. Josef S Smolen, Daniel Aletaha, Iain B McInnesLancet201627156434No
390711241124.027.827.8The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
390811241124.026.626.6Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
390911241124.035.735.7Biomedical photoacoustic imaging. Paul BeardInterface Focus201122866233Yes
391011231123.032.932.9Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
391111231123.041.441.4Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
391211231123.033.033.0Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
391311231123.026.526.5Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
391411231123.045.045.0Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Hannah R SnyderPsychol Bull201322642228No
391533681122.772.324.1Mitochondria, oxidants, and aging. Robert S Balaban, Shino Nemoto, Toren FinkelCell200515734681No
391622451122.552.026.0A note on quantifying follow-up in studies of failure time. M Schemper, T L SmithControl Clin Trials19968889347Yes
391711221122.029.629.6The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
391811221122.023.223.2ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
391911221122.022.922.9The mitochondrial genome: structure, transcription, translation and replication. J W TaanmanBiochim Biophys Acta199910076021No
392011221122.020.320.3Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
392111221122.031.631.6Conceptual synthesis in community ecology. Mark VellendQ Rev Biol201020565040No
392211221122.038.538.5Microbial life in the phyllosphere. Julia A VorholtNat Rev Microbiol201223154261No
392333661122.0113.637.9The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Stefka Tyanova, Tikira Temu, Juergen CoxNat Protoc201627809316Yes
392411211121.023.623.6Pyramidal neurons: dendritic structure and synaptic integration. Nelson SprustonNat Rev Neurosci200818270515No
392511211121.039.439.4T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. Shane CrottyImmunity201931117010No
392622411120.562.731.4Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
392733611120.3119.139.7Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
392844811120.2115.428.9Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
392911201120.037.337.3A measure of anxiety symptoms among children. S H SpenceBehav Res Ther19989648330Yes
393011201120.021.221.2Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
393111201120.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DEESEJ Exp Psychol195913664879Yes
393211201120.026.826.8The role of acetylcholine in learning and memory. Michael E HasselmoCurr Opin Neurobiol200617011181No
393333591119.779.826.6In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Chun-Chi Liang, Ann Y Park, Jun-Lin GuanNat Protoc200717406593Yes
393411191119.037.137.1Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
393511191119.035.535.5Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
393611191119.019.019.05-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Judith K ChristmanOncogene200212154409No
393711191119.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B REXEDJ Comp Neurol195413163236Yes
393811191119.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EASTERBROOKPsychol Rev195913658305Yes
393933551118.3157.852.6The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Karen V Swanson, Meng Deng, Jenny P-Y TingNat Rev Immunol201931036962No
394022361118.094.747.4Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
394111181118.040.540.5An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. F G HappeJ Autism Dev Disord19948040158Yes
394211181118.023.023.0Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
394322361118.053.626.8The neural basis of decision making. Joshua I Gold, Michael N ShadlenAnnu Rev Neurosci200717600525No
394411181118.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
394511171117.023.923.9New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
394622341117.026.513.2Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P GOLD, S O FREEDMANJ Exp Med196514270243Yes
394711171117.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SPERRYJ Comp Physiol Psychol195014794830Yes
394811171117.026.826.8Hybridization as an invasion of the genome. James MalletTrends Ecol Evol200516701374Yes
394911171117.030.030.0Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
395011171117.025.125.1Mucins in cancer: function, prognosis and therapy. Donald W KufeNat Rev Cancer200919935676No
395122331116.553.826.9Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
395211161116.033.833.8Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
395344641116.084.221.1DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
395411161116.027.027.0Biological effects of resveratrol. L FremontLife Sci200010680575No
395511161116.059.559.5Cisplatin: The first metal based anticancer drug. Sumit GhoshBioorg Chem201931003078No
395622311115.565.832.9A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
395722311115.532.416.2Microdroplet Assay Of Human Serum Cytotoxins. P I TERASAKI, J D MCCLELLANDNature196414248725Yes
395811151115.030.430.4Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
395911151115.011.511.5Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. J J HopfieldProc Natl Acad Sci U S A19744530290Yes
396011151115.013.313.3Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
396111151115.036.836.8Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
396211151115.036.536.5Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
396311151115.028.228.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
396411151115.018.418.4Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
396511151115.024.624.6The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
396644591114.8140.835.2Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
396722291114.546.623.3InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
396822291114.552.526.2Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie Beral, Lancet200312927427Yes
396911141114.055.455.4The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
397011141114.036.336.3Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
397111141114.025.225.2P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
397222281114.0112.856.4Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Laura M Doyle, Michael Zhuo WangCells201931311206No
397311131113.028.028.0Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
397422261113.051.825.9The oxytocin receptor system: structure, function, and regulation. G Gimpl, F FahrenholzPhysiol Rev200111274341No
397511131113.022.522.5The muscular dystrophies. Alan E H EmeryLancet200211879882No
397611131113.020.620.6mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
397722251112.5100.950.5Neurobiology of addiction: a neurocircuitry analysis. George F Koob, Nora D VolkowLancet Psychiatry201627475769No
397811121112.029.929.9Innate immunity of fish (overview). Bergljot MagnadottirFish Shellfish Immunol200615950491No
397911121112.027.127.1Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Richard M CawthonNucleic Acids Res200919129229Yes
398022231111.5108.454.2Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
398122231111.569.634.8Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
398244461111.5197.649.4Random effects structure for confirmatory hypothesis testing: Keep it maximal. Dale J Barr, Roger Levy, Christoph Scheepers, Harry J TilyJ Mem Lang201324403724Yes
398333341111.3116.939.0IL-6 in inflammation, immunity, and disease. Toshio Tanaka, Masashi Narazaki, Tadamitsu KishimotoCold Spring Harb Perspect Biol201425190079No
3984111121111.2392.339.2The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherPLoS Med200919621070No
398511111111.023.223.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
398611111111.021.721.7Cytokine receptor signalling. J N IhleNature19957566171No
398711111111.025.525.5Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
398822221111.045.722.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
398911111111.031.631.6Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
399011111111.032.532.5Spontaneous dissection of the carotid and vertebral arteries. W I SchievinkN Engl J Med200111259724No
399122221111.046.523.2Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. P J Roberts, C J DerOncogene200717496923No
399211101110.025.825.8A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
399311101110.029.429.4Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
399411101110.042.942.9Epithelial Mesenchymal Transition in Tumor Metastasis. Vivek MittalAnnu Rev Pathol201829414248No
399544391109.8102.325.6The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
3996144281109.8379.029.2The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , JAMA200312748199No
399722191109.577.338.6Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
399833281109.3133.944.6A new method for detecting anaerobic threshold by gas exchange. W L Beaver, K Wasserman, B J WhippJ Appl Physiol (1985)19863087938Yes
399911091109.022.122.1Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
400022181109.053.626.8The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
400122181109.043.921.9In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KarreImmunol Today19902201309No
400211091109.022.422.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
400311091109.025.625.6The emotional brain, fear, and the amygdala. Joseph LeDouxCell Mol Neurobiol200314514027No
400422181109.053.426.7Inflammatory bowel disease. Clara Abraham, Judy H ChoN Engl J Med200919923578No
400511091109.029.929.9Voltage-gated calcium channels. William A CatterallCold Spring Harb Perspect Biol201121746798No
400622181109.088.244.1Global estimates of visual impairment: 2010. Donatella Pascolini, Silvio Paolo MariottiBr J Ophthalmol201222133988Yes
400722181109.058.529.2DNA methylation: roles in mammalian development. Zachary D Smith, Alexander MeissnerNat Rev Genet201323400093No
400811091109.045.345.3How Many Subjects Does It Take To Do A Regression Analysis. S B GreenMultivariate Behav Res199126776715Yes
400933261108.7108.736.2Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
401011081108.061.061.0The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
401122161108.061.330.6Flexible regression models with cubic splines. S Durrleman, R SimonStat Med19892657958Yes
401211081108.021.621.6Automated NMR structure calculation with CYANA. Peter GuntertMethods Mol Biol200415318003Yes
401322151107.579.039.5Perceived discrimination and health: a meta-analytic review. Elizabeth A Pascoe, Laura Smart RichmanPsychol Bull200919586161Yes
401411071107.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TEALEBiochim Biophys Acta195913837237Yes
401511071107.020.320.3Cytokines in cancer pathogenesis and cancer therapy. Glenn DranoffNat Rev Cancer200414708024No
401611071107.024.624.6Pathogenesis of atherosclerosis. Erling FalkJ Am Coll Cardiol200616631513Yes
401722141107.064.132.0Genome-wide efficient mixed-model analysis for association studies. Xiang Zhou, Matthew StephensNat Genet201222706312Yes
401844271106.8113.028.2A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
401944261106.5159.339.8Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
402044261106.5108.027.0An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
402122131106.562.931.4Neural regulation of endocrine and autonomic stress responses. Yvonne M Ulrich-Lai, James P HermanNat Rev Neurosci200919469025No
402211061106.023.023.0The molecular biology of coronaviruses. Paul S MastersAdv Virus Res200616877062No
402311061106.025.625.6NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Weihai YingAntioxid Redox Signal200818020963No
402411061106.058.658.6COVID-19: immunopathology and its implications for therapy. Xuetao CaoNat Rev Immunol202032273594Yes
402522111105.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H COONS, M H KAPLANJ Exp Med195015395569Yes
402622111105.580.040.0Ferroptosis: Death by Lipid Peroxidation. Wan Seok Yang, Brent R StockwellTrends Cell Biol201626653790No
402733161105.3109.536.5A new rating scale for Alzheimer's disease. W G Rosen, R C Mohs, K L DavisAm J Psychiatry19846496779Yes
402822101105.064.732.4Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
402911051105.00.00.0Asymptomatic infections of the urinary tract. E H KASSTrans Assoc Am Physicians195613380946Yes
403011051105.034.934.9Vitamin D status: measurement, interpretation, and clinical application. Michael F HolickAnn Epidemiol200918329892No
403155231104.6115.023.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
403222091104.548.724.4Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
403333131104.3121.740.6Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Michael A Postow, Robert Sidlow, Matthew D HellmannN Engl J Med201829320654No
403411041104.038.938.9Perceptual selectivity for color and form. J TheeuwesPercept Psychophys19921620571No
403511041104.029.829.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
403611041104.021.621.6Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
403711031103.022.122.1Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
403822061103.056.228.1Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. L Pellerin, P J MagistrettiProc Natl Acad Sci U S A19947938003Yes
403911031103.031.931.9Image matching as a diffusion process: an analogy with Maxwell's demons. J P ThirionMed Image Anal19989873902Yes
404022061103.060.130.1The spread of obesity in a large social network over 32 years. Nicholas A Christakis, James H FowlerN Engl J Med200717652652Yes
404111031103.033.133.1The enteric nervous system and neurogastroenterology. John B FurnessNat Rev Gastroenterol Hepatol201222392290No
404244111102.8113.028.2REVIGO summarizes and visualizes long lists of gene ontology terms. Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav SmucPLoS One201121789182Yes
404322051102.554.127.1Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. D Rice, S BaroneEnviron Health Perspect200010852851No
404422051102.549.424.7Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
404522041102.045.122.6p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
404622031101.538.219.1Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
404766071101.2148.124.7Alpha-synuclein in Lewy bodies. M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M GoedertNature19979278044Yes
404811011101.033.833.8The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
404911011101.021.021.0The evolutionary significance of cis-regulatory mutations. Gregory A WrayNat Rev Genet200717304246No
405022021101.053.426.7Recent developments in the MAFFT multiple sequence alignment program. Kazutaka Katoh, Hiroyuki TohBrief Bioinform200818372315Yes
405111011101.027.927.9Descending pathways in motor control. Roger N LemonAnnu Rev Neurosci200818558853No
405222021101.079.940.0The blood-brain barrier. Richard Daneman, Alexandre PratCold Spring Harb Perspect Biol201525561720No
405322011100.571.435.7Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
405422011100.565.432.72,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
405522011100.563.431.7The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
405644011100.2148.437.1Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
405711001100.026.926.9Avidin. N M GreenAdv Protein Chem1975237414Yes
405811001100.041.841.8The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
405911001100.024.124.1The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
406011001100.021.521.5Unfolding the role of protein misfolding in neurodegenerative diseases. Claudio SotoNat Rev Neurosci200312511861No
406122001100.052.026.0The NF-kappaB family of transcription factors and its regulation. Andrea Oeckinghaus, Sankar GhoshCold Spring Harb Perspect Biol200920066092No
406222001100.052.226.1CpG islands and the regulation of transcription. Aimee M Deaton, Adrian BirdGenes Dev201121576262No
406365981099.7164.327.4Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
406421991099.50.00.0Micromethod for the direct determination of serum triglycerides. E VAN HANDEL, D B ZILVERSMITJ Lab Clin Med195713439279Yes
406521981099.064.332.1Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
406610991099.023.823.8Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
406721981099.048.724.4How to interpret LC3 immunoblotting. Noboru Mizushima, Tamotsu YoshimoriAutophagy200717611390No
406810981098.020.620.6Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
406910981098.020.620.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
407010981098.019.019.0Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
407121961098.045.222.6An energy budget for signaling in the grey matter of the brain. D Attwell, S B LaughlinJ Cereb Blood Flow Metab200111598490No
407210981098.022.922.9Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
407310981098.023.623.6Cells of origin in cancer. Jane E VisvaderNature201121248838No
407421961098.0114.357.1Cytokine Storm. David C Fajgenbaum, Carl H JuneN Engl J Med202033264547No
407521951097.593.746.9Network analysis: an integrative approach to the structure of psychopathology. Denny Borsboom, Angelique O J CramerAnnu Rev Clin Psychol201323537483No
407621951097.578.839.4NAFLD: a multisystem disease. Christopher D Byrne, Giovanni TargherJ Hepatol201525920090No
407710971097.045.045.0Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
407821941097.081.941.0The structure of psychological well-being revisited. C D Ryff, C L KeyesJ Pers Soc Psychol19957473027Yes
407910971097.023.723.7A cortical-hippocampal system for declarative memory. H EichenbaumNat Rev Neurosci200011252767No
408021931096.589.044.5Emotional processing of fear: exposure to corrective information. E B Foa, M J KozakPsychol Bull19862871574Yes
408121931096.534.717.4Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
408243861096.5151.737.9Development of recommendations for SEMG sensors and sensor placement procedures. H J Hermens, B Freriks, C Disselhorst-Klug, G RauJ Electromyogr Kinesiol200011018445Yes
408310961096.032.432.4Comparing evolvability and variability of quantitative traits. D HouleGenetics19921732160Yes
408410961096.018.818.8Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
408510961096.013.713.7The evolutionary advantage of recombination. J FelsensteinGenetics19744448362Yes
408610961096.024.624.6The primate basal ganglia: parallel and integrative networks. Suzanne N HaberJ Chem Neuroanat200314729134No
408710961096.025.625.6Ab-initio simulations of materials using VASP: Density-functional theory and beyond. Jurgen HafnerJ Comput Chem200818623101Yes
408810961096.030.930.9Lanthanide-based luminescent hybrid materials. Koen BinnemansChem Rev200919650663Yes
408943821095.5117.129.3A role for mitochondria in NLRP3 inflammasome activation. Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg TschoppNature201121124315Yes
409010951095.037.437.4A theory of visual attention. C BundesenPsychol Rev19902247540Yes
409121901095.068.134.0Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
409210951095.029.329.3Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
409332851095.0190.363.4Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
409410941094.025.125.1Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
409510941094.020.420.4The immune response of Drosophila. Jules A HoffmannNature200314603309No
409610941094.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WYATTBiochem J195114838906Yes
409710941094.022.422.4Large-scale recording of neuronal ensembles. Gyorgy BuzsakiNat Neurosci200415114356No
409810941094.018.318.3The concept of synthetic lethality in the context of anticancer therapy. William G KaelinNat Rev Cancer200516110319No
409921871093.548.924.4Mechanisms of endocytosis. Gary J Doherty, Harvey T McMahonAnnu Rev Biochem200919317650No
410032801093.390.730.2Foreign body reaction to biomaterials. James M Anderson, Analiz Rodriguez, David T ChangSemin Immunol200818162407No
410110931093.020.120.1Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
410210931093.011.511.5The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CRONEActa Physiol Scand196314078649Yes
410321861093.065.632.8The human microbiome: at the interface of health and disease. Ilseung Cho, Martin J BlaserNat Rev Genet201222411464No
410410931093.034.234.2Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
410576491092.7688.198.3The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James RubinLancet202032112714No
410610921092.032.432.4Topography of cognition: parallel distributed networks in primate association cortex. P S Goldman-RakicAnnu Rev Neurosci19883284439No
410710921092.023.023.0The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
410810921092.038.238.2Coronary physiology. E O FeiglPhysiol Rev19836296890No
410910921092.024.824.8Marine viruses and their biogeochemical and ecological effects. J A FuhrmanNature199910376593No
411010921092.032.032.0The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. R CharonJAMA200111597295Yes
411110921092.027.227.2Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Jill E ClarridgeClin Microbiol Rev200415489351No
411210921092.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PARTRIDGENature194918140444Yes
411310921092.034.834.8Designing cell-compatible hydrogels for biomedical applications. Dror SeliktarScience201222654050No
411410911091.033.433.4Prevention of drug access to bacterial targets: permeability barriers and active efflux. H NikaidoScience19948153625No
411521821091.057.828.9The cerebellar cognitive affective syndrome. J D Schmahmann, J C ShermanBrain19989577385Yes
411610911091.023.723.7Immunosuppressive drugs for kidney transplantation. Philip F HalloranN Engl J Med200415616206No
411710911091.026.426.4Sleep-dependent memory consolidation. Robert StickgoldNature200516251952No
411810911091.030.930.9Cytochrome p450 and chemical toxicology. F Peter GuengerichChem Res Toxicol200818052394No
411910911091.025.825.8Trypan blue exclusion test of cell viability. W StroberCurr Protoc Immunol200118432654Yes
412021821091.076.538.2Coronaviruses: an overview of their replication and pathogenesis. Anthony R Fehr, Stanley PerlmanMethods Mol Biol201525720466No
412110911091.035.435.4Targeting metastasis. Patricia S SteegNat Rev Cancer201627009393No
412210911091.042.742.7Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. Peter J BarnesJ Allergy Clin Immunol201627373322No
412321811090.546.423.2Glycosylation in cellular mechanisms of health and disease. Kazuaki Ohtsubo, Jamey D MarthCell200616959566No
412421801090.043.621.8A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
412543601090.0111.127.8Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
412610901090.029.429.4Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. R BonnetAntimicrob Agents Chemother200414693512No
412710901090.027.527.5Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Paul H YanceyJ Exp Biol200516043587No

              Download as CSV


Copyright © 2020-2023 Solid Scientometrics Sp. z o.o.                                         Terms of Service                                                             Designed by Lukasz P. Kozlowski

All information that Unicorn Papers provides is based on PubMed data that are within the public domain. We acknowledge the NCBI, NLM, ORCID and iCite teams.