Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 4236 papers with ECcit ≥ 1112.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 71, July 2026

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1226677226677.06239.26239.2Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2184158184158.06042.16042.1A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328871872179.50.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
414408572042.53973.21986.6Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54710947109.01513.51513.5A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63950539505.01315.71315.7Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76484132420.52017.21008.6Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83076030760.0783.0783.0MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
93028130281.0791.1791.1Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
103009130091.0919.2919.2The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
112944529445.0685.3685.3MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
122828728287.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
132705927059.0679.3679.3A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142618126181.0846.5846.5Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
152506725067.0707.4707.4Projector augmented-wave method. P E BlochlPhys Rev B Condens Matter19949976227Yes
164961824809.01534.5767.2Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
177150323834.32558.2852.7"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
187021623405.32526.3842.1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
192249022490.0782.0782.0Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
206653722179.01625.5541.8DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
214257521287.51370.0685.0The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
222086120861.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
232080120801.0839.8839.8RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
244126820634.01288.8644.4Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
252054520545.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
264079120395.51629.4814.7The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
276059820199.31867.9622.6Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
283832419162.01852.8926.4Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
293794718973.5986.7493.4Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
301885218852.0643.6643.6A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
311884018840.0853.1853.1A power primer. J CohenPsychol Bull199219565683Yes
321822318223.0860.8860.8Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
335371917906.31604.7534.9Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
341747517475.0477.8477.8Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
353474417372.01417.9709.0The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
363410917054.5961.4480.7Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmullerPhys Rev B Condens Matter19969984901Yes
373379816899.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
381685316853.0669.6669.6Catalase in vitro. H AebiMethods Enzymol19846727660Yes
391678316783.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
403310416552.01276.7638.4Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
411646316463.0422.7422.7MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
421623916239.0433.4433.4High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
431594615946.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
441569315693.0613.2613.2Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
454685815619.31411.7470.6CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
464679615598.71743.9581.3Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
472973314866.51111.6555.8MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
481476214762.0530.5530.5Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
491454114541.0372.9372.9Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
504352814509.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
512873814369.0896.7448.4Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
521420714207.0609.3609.3Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
532817414087.0599.7299.9Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
542801814009.0654.2327.1KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
556997813995.62080.5416.1Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
561394213942.0618.4618.4Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
571379713797.0448.5448.5Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
584065713552.31447.2482.4Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
591353413534.0449.6449.6The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
604057913526.31105.5368.5VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
612682813414.01193.5596.8The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
621330713307.0225.0225.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
633987613292.01329.0443.0NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
641289612896.0436.0436.0Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
651266512665.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
661264512645.0506.7506.7A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
671251112511.0579.9579.9SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
684930012325.01599.9400.0Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
692458412292.0558.6279.3Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
701154011540.0318.7318.7Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
712262911314.5974.9487.4The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
722228811144.0701.2350.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
733335511118.31118.8372.9The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
741107511075.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
751095610956.0385.7385.7Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
761087710877.0307.3307.3The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
772155810779.0570.7285.4A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
784301010752.51546.9386.7Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
791070810708.0461.6461.6Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
804280810702.01599.9400.0A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
813195510651.7860.7286.9edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
821050910509.0300.5300.5Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
831041910419.0261.3261.3PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
841034910349.0438.5438.5Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
851031710317.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
862059510297.5566.5283.2Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
871029010290.0221.9221.9Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
882054810274.0496.3248.2BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
891026910269.0271.3271.3Canonical dynamics: Equilibrium phase-space distributions. W G HooverPhys Rev A Gen Phys19859895674Yes
901023910239.0416.6416.6UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
911005110051.0305.0305.0Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
92198279913.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
93197279863.51231.0615.5A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
94196989849.0507.6253.8A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
9598369836.0269.5269.5Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
96392039800.81409.0352.2G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
97195769788.0483.2241.6WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
9897719771.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
99195119755.5435.4217.7The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
100292499749.7766.2255.4Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
10197489748.0270.9270.9RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
10297059705.0327.9327.9Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
103289639654.31114.8371.6Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
104192679633.5732.0366.0Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
10595769576.0259.5259.5Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
106189799489.5434.6217.3Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
107474289485.61911.8382.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, PLoS Med200919621072No
10894799479.0263.5263.5Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
109282899429.71449.3483.1MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
11092979297.0290.9290.9AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
11192929292.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
11292529252.0241.8241.8Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
11392269226.0272.9272.9The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
11491209120.0189.9189.9Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
11590779077.0242.9242.9Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
116271599053.0948.4316.1Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
11789608960.0198.6198.6The functions of animal microRNAs. Victor AmbrosNature200415372042No
11889298929.0442.6442.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11988048804.0391.1391.1Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
120174078703.5413.7206.8Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
12184938493.0238.9238.9Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
12284138413.0331.2331.2The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
123167908395.0529.2264.6EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
12483828382.0284.9284.9An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
12583818381.0230.0230.0Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12683348334.0276.0276.0The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
127165258262.5442.6221.3MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
128164328216.0455.0227.5RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
129164078203.5579.1289.6Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
130163448172.0459.9229.9Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
13181648164.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
13281538153.0177.6177.6Chromatin modifications and their function. Tony KouzaridesCell200717320507No
13380958095.0151.9151.9Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
13480948094.0233.0233.0A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
13580598059.0272.4272.4Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
13679607960.0221.1221.1"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
13779147914.0226.1226.1A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
13878907890.0261.6261.6The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
139235697856.3690.5230.2Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
14077997799.0224.3224.3The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
14177467746.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BoyumScand J Clin Lab Invest Suppl19684179068Yes
14277327732.0212.0212.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
143538507692.91484.0212.0Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
14474317431.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
14573977397.0260.4260.4Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
14673817381.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
147145477273.5621.0310.5Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14872657265.0262.8262.8FreeSurfer. Bruce FischlNeuroimage201222248573No
14971707170.0641.5641.5Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
15071617161.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15171067106.0204.9204.9TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
15271067106.0321.1321.1Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
153424567076.01545.8257.6Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
154140857042.5339.4169.7Continuous cultures of fused cells secreting antibody of predefined specificity. G Kohler, C MilsteinNature19751172191Yes
15569976997.0177.7177.7Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
15669626962.0144.9144.9Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
15769276927.0176.2176.2Inflammation and metabolic disorders. Gokhan S HotamisligilNature200617167474No
15868786878.0187.8187.8The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
15968506850.0169.9169.9Inflammation, atherosclerosis, and coronary artery disease. Goran K HanssonN Engl J Med200515843671No
160136876843.5463.9231.9The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
161272156803.8812.7203.2clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
16267856785.0226.9226.9Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
163135386769.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
164134666733.0342.1171.1Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
165201736724.3787.7262.6Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16667176717.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
167201006700.0640.4213.5featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
168133996699.5535.3267.6phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
16966706670.0162.0162.0Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
17066386638.0169.9169.9Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
17166146614.0179.1179.1Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
172198346611.3573.2191.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
173131516575.5430.8215.4Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
17465576557.0153.2153.2Inflammation in atherosclerosis. Peter LibbyNature200212490960No
17565516551.0174.8174.8Adhesion receptors of the immune system. T A SpringerNature19901974032No
17665486548.0168.1168.1Free radicals in the physiological control of cell function. Wulf DrogePhysiol Rev200211773609No
17765456545.0193.2193.2A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
17865286528.0126.3126.3BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
179130476523.5366.9183.4Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
18065166516.0256.8256.8Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
18164946494.0143.5143.5p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
18264326432.0133.0133.0Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
183255326383.0808.8202.2A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
18463746374.0149.4149.4MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
185126936346.5297.3148.7One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18663316331.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
18763296329.0159.7159.7Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
188126536326.5294.2147.1Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
189125156257.5338.6169.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
19062316231.0143.2143.2Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
19162156215.0172.5172.5How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
192248476211.8637.1159.3Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
193122926146.0351.8175.9A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
194122706135.0275.3137.7MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jurgen Cox, Matthias MannNat Biotechnol200819029910Yes
19560916091.0176.0176.0Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
19660876087.0226.4226.4The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
19760866086.0158.1158.1G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
198121486074.0431.6215.8Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
19960566056.0158.2158.2Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
20060356035.0276.9276.9Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniel LakensFront Psychol201324324449No
201120136006.5309.5154.8Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
202239615990.2623.3155.8Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
20359635963.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
20459615961.0219.1219.1Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
205119225961.0328.3164.2Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
20659555955.0150.0150.0Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
20759485948.0200.3200.3jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
208178205940.0725.8241.9Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
20959355935.0246.2246.2Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
210118615930.5267.9133.9Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
211177915930.3678.7226.2The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
21258865886.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
213117035851.5431.7215.8A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
21457805780.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
21557795779.093.893.8Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
216115205760.0725.6362.8Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
217172405746.7700.4233.5A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
21857375737.0150.1150.1Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
219114685734.0467.6233.8Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
220114655732.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
221114515725.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
222171105703.3625.7208.6HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
22356775677.0173.6173.6Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
224113405670.0284.9142.4A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stephane Guindon, Olivier GascuelSyst Biol200314530136Yes
22556505650.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
226169295643.0467.8155.9Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
227112795639.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
228168525617.3519.7173.2A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
22956105610.0131.6131.6The biochemistry of apoptosis. M O HengartnerNature200011048727No
230223215580.2784.1196.0A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LoweArch Intern Med200616717171Yes
231110395519.5253.2126.6Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
23254965496.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
23354905490.0111.4111.4Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
23454835483.0184.5184.5Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
23554705470.0112.9112.9Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23654685468.0146.8146.8Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
237109315465.5254.0127.0The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
238109245462.0263.1131.6Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
239162905430.0559.1186.4HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
240108495424.5335.7167.8MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
24154165416.0157.7157.7The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
242108285414.0422.8211.4Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
243108105405.0265.1132.6Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
244107905395.00.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
245269735394.6791.8158.4The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
246107585379.00.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
24753095309.0138.4138.4New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
24852655265.0131.9131.9The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
24952575257.0157.7157.7Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
25052435243.0196.4196.4Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
25152215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
252104315215.5291.5145.8The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
253104275213.5338.4169.2The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
25452115211.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
25552105210.0152.4152.4Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
256156265208.7502.4167.5Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
257260315206.21097.1219.4MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
258103725186.0277.4138.7Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
25951825182.0106.8106.8Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
260155105170.0703.6234.5Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
26151685168.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
262103035151.5284.2142.1Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schagger, G Von JagowAnal Biochem19872449095Yes
26351505150.0129.3129.3Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
264102925146.0245.8122.9A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
26551445144.0201.4201.4Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
26651415141.094.994.9The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
267257005140.00.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
268102575128.5421.2210.6The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
26951285128.098.898.8DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
27051105110.0154.8154.8DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
271102045102.0436.6218.3The qualitative content analysis process. Satu Elo, Helvi KyngasJ Adv Nurs200818352969Yes
272101615080.50.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
273202545063.50.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
274354125058.9829.1118.4UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
275101045052.0442.8221.4The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
276251865037.21010.2202.0The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
277150155005.0554.2184.7Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
27899664983.0253.2126.6Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
279198284957.0918.9229.7fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
28049474947.0162.6162.6A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
28198594929.5314.7157.3Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
28249184918.0141.1141.1Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
28349124912.0208.6208.6The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
28449124912.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
28549074907.0101.4101.4An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
28697984899.0325.0162.5FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoc, Steven L SalzbergBioinformatics201121903629Yes
28797944897.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
288146704890.0406.3135.4Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
28997764888.0324.8162.4Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
29048864886.0115.9115.9Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
29148664866.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
29248584858.0179.7179.7Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
293145534851.00.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
29448434843.0112.3112.3Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
29548364836.0110.8110.8ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
29648334833.0108.6108.6Cancer cell cycles. C J SherrScience19968939849No
297144534817.7330.0110.0Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
298144414813.7371.9124.0A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
29948094809.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
30047914791.0105.4105.4Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
30147894789.0132.4132.4Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
30247874787.0184.6184.6Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
30395684784.0338.4169.2Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30495324766.0174.487.2A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J Van Der EbVirology19734705382Yes
30547484748.0101.3101.3Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
30694924746.0242.4121.2Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
30747304730.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
30847284728.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
30994384719.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
310141314710.3576.6192.2A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
31147064706.0162.9162.9The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
31247064706.0187.9187.9EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31347044704.0124.6124.6A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
31447034703.0120.0120.0Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
31594014700.5280.2140.1Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
316187374684.2575.1143.8MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
31746824682.0134.9134.9Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
31846804680.099.699.6Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
31946784678.0117.3117.3A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
32046754675.0155.8155.8Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
32146704670.0152.0152.0How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
32246614661.0124.4124.4Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
32393064653.0231.3115.7Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
32493004650.0226.3113.2Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
32546424642.0108.9108.9Cancer. p53, guardian of the genome. D P LaneNature19921614522No
32646264626.0176.2176.2A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
32746084608.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
32891954597.5225.8112.9SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
32991934596.5255.7127.8A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
33045844584.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B de B WeirJ Physiol194915394301Yes
331137474582.3504.2168.1Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
33245804580.0168.8168.8KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
333456544565.41189.1118.9The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, Bioinformatics200919505943Yes
33445624562.0100.8100.8ras genes. M BarbacidAnnu Rev Biochem19873304147No
33545624562.0101.1101.1Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
33645594559.091.091.0The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
337227844556.81343.9268.8MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
33845544554.095.295.2Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
339181924548.0698.4174.6Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
340272844547.3908.2151.4Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
34145474547.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
34289584479.0258.2129.1Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
34344754475.0125.1125.1Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34444524452.0122.4122.4Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
345266974449.5983.5163.9MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
34644494449.0126.8126.8Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
34744494449.0109.0109.0RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
34844474447.0103.7103.7Atherosclerosis. A J LusisNature200011001066No
34944464446.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
35088904445.0244.8122.4tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
35188834441.50.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
35244404440.0109.7109.7Mechanisms of angiogenesis. W RisauNature19979109485No
35344354435.0112.1112.1A new method for predicting signal sequence cleavage sites. G Von HeijneNucleic Acids Res19863714490Yes
35488314415.5293.8146.9DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35543924392.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
35687724386.0236.1118.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
35743804380.078.278.2Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
35887534376.5197.098.5Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
35987444372.00.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
36043664366.0113.7113.7The origins and the future of microfluidics. George M WhitesidesNature200616871203No
36143574357.0170.7170.7Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
36243534353.0131.9131.9Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
36343494349.0227.8227.8High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
36443464346.0101.1101.1PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
36543414341.0176.4176.4A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
36643364336.0116.5116.5Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
367390034333.71224.5136.1STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
36843314331.0127.3127.3Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
36986604330.0220.5110.2The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
37043244324.0137.2137.2EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
37143234323.0165.1165.1Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
37243194319.082.382.3Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
373302064315.11087.4155.3limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
37443014301.094.594.5Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37542954295.090.490.4The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
37685844292.00.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
37742914291.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
37842894289.087.487.4Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
37942884288.079.579.5Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
38042874287.092.192.1The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
38142714271.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
38242674267.0115.2115.2The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
38342664266.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
384127884262.7424.0141.3Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
38542584258.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
386127374245.71165.6388.5MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
387169454236.2719.8179.9IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt Von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
38842364236.096.196.1Apoptosis by death factor. S NagataCell19979039262No
389169444236.0401.0100.2Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
39042354235.0100.1100.1Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
391126904230.0467.1155.7Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
39242274227.0134.1134.1Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
39342254225.0115.5115.5Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39442224222.097.997.9Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
395168874221.8991.6247.9Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
39642184218.0119.1119.1Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
39742034203.0132.4132.4adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
39842024202.089.489.4Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
39942014201.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
40084014200.5236.8118.4Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
40183884194.0232.4116.2An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
40241914191.0173.4173.4You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
403125734191.0314.8104.9Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
40483814190.5471.6235.8The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
40541744174.0155.7155.7Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
40641734173.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
40783444172.0214.3107.2The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
40841704170.0102.3102.3Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
40941664166.0104.0104.0Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
41041644164.0133.5133.5Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
411372914143.4855.495.0Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
41282844142.0185.192.5Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
41341264126.0146.1146.1Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
41441104110.0117.6117.6Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
41582054102.5291.7145.8Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
41640944094.0130.4130.4What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41740874087.0146.4146.4Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
418122314077.0248.582.8Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
41981514075.5156.578.2Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
42040724072.0113.3113.3How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
42140724072.090.190.1Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
42240704070.088.988.9Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
42340614061.091.691.6Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
42440584058.094.794.7Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
42581094054.5155.777.8A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
42640404040.0111.6111.6The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
42780624031.0235.7117.8BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
42840274027.0107.3107.3Integrins: a family of cell surface receptors. R O HynesCell19873028640No
42940264026.0110.5110.5What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
43040264026.0125.5125.5Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
43180504025.0202.9101.5Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
43240204020.0101.9101.9Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
43380194009.5257.1128.6Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
43440004000.0134.6134.6Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
43539823982.0133.5133.5genepop'007: a complete re-implementation of the genepop software for Windows and Linux. Francois RoussetMol Ecol Resour200821585727Yes
43679613980.5303.0151.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
43739793979.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
43839623962.0111.7111.7Graphene: status and prospects. A K GeimScience200919541989Yes
43939573957.0116.0116.0The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
44079063953.0322.3161.2The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
44139503950.0134.8134.8Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
44239473947.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
44339423942.077.077.0Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
44439363936.0130.7130.7No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
445118063935.3298.199.4Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
44639333933.098.598.5I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
44739283928.0129.0129.0Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
44878523926.0166.483.2Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
44939233923.090.090.0Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
450117613920.3335.2111.7GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hanzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
45139173917.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
45239043904.0103.4103.4The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
45339023902.0106.0106.0Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
45438883888.097.897.8Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
45538773877.0104.3104.3Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
45677423871.0640.3320.1Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
45738623862.0179.7179.7The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
45877143857.0298.2149.1Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
45938563856.0137.9137.9Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
460115483849.3284.394.8ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
46138473847.0116.9116.9Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
46238453845.0111.6111.6Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
46338413841.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
46476433821.5195.097.5Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
46538163816.081.681.6TGF-beta signal transduction. J MassagueAnnu Rev Biochem19989759503No
46638133813.093.793.7Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrungerNature199218481394Yes
46776173808.5174.887.4Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
46838073807.0149.9149.9Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
46938053805.0129.9129.9The Danish Civil Registration System. Carsten Bocker PedersenScand J Public Health201121775345Yes
47038033803.079.179.1A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
47137943794.0156.4156.4Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
472417343794.0911.582.9Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
47337923792.0160.0160.0Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
474113603786.7280.793.6Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
47537633763.082.082.0Profile hidden Markov models. S R EddyBioinformatics19989918945No
47637593759.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
477187933758.6733.9146.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Ann Intern Med200919622511No
47837553755.0108.7108.7Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
47937473747.066.966.9Somatic generation of antibody diversity. S TonegawaNature19836300689No
48037403740.0180.8180.8Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
481112033734.3217.372.4Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
48274463723.0222.6111.3Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
48337223722.0131.7131.7Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
48437193719.0108.0108.0Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
48574263713.0176.788.3Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
48637053705.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
48737053705.091.491.4Glutamate uptake. N C DanboltProg Neurobiol200111369436No
48873683684.0222.6111.3Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
48936833683.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
49036743674.0130.1130.1Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
49173463673.0138.369.2Translating the histone code. T Jenuwein, C D AllisScience200111498575No
49273423671.00.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
49336633663.0162.9162.9Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
49436593659.0132.0132.0Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
49536543654.099.499.4The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49636533653.077.677.6Mammalian neural stem cells. F H GageScience200010688783No
49736533653.089.289.2Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
49873013650.5227.3113.7The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
49973003650.0148.374.2Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
50036433643.060.860.8Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
50136413641.090.490.4Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
50236393639.072.872.8Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
50336373637.0136.8136.8Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
50436343634.0114.3114.3Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
50536343634.080.580.5Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
506181613632.2687.7137.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, BMJ200919622551No
50772463623.00.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
50836203620.0133.9133.9Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
50936053605.097.797.7Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
51036033603.092.392.3Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
51136003600.0112.0112.0Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
51235973597.0114.3114.3The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
51371893594.5209.0104.5Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51435913591.0194.2194.2Obesity: global epidemiology and pathogenesis. Matthias BluherNat Rev Endocrinol201930814686No
51535883588.086.386.3Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
516214873581.21066.7177.8DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
51771523576.0190.395.2The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
51835753575.090.290.2The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
519107183572.7319.9106.6FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
52071443572.0140.270.1The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
52171373568.5177.288.6Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
52235623562.077.077.0Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
523284813560.1666.883.3The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
52470833541.5144.572.2A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
52535413541.078.978.9Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
52635403540.097.397.3Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
52735333533.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
52870633531.5206.4103.2Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52935283528.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
53070463523.0236.9118.5Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
531176113522.2500.3100.1Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
53235193519.0187.4187.4Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
53335193519.092.992.9Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
53435173517.070.270.2The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
53535113511.0121.4121.4What is value in health care? Michael E PorterN Engl J Med201021142528Yes
53635083508.0108.6108.6Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
53770053502.5158.879.4Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
53834983498.089.589.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
53969923496.0158.979.5Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
54069873493.5199.499.7Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
54134843484.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
54234763476.096.496.4Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
54369523476.0200.2100.1mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
544104233474.3544.1181.4Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
54569393469.5266.5133.2Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54634663466.075.175.1Protein folding and misfolding. Christopher M DobsonNature200314685248No
547103813460.3322.3107.4Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
54834563456.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
54934523452.085.285.2Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
55068953447.5168.184.0In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
55168943447.0297.6148.8GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
55268793439.5169.684.8"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
55334383438.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
55468713435.50.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55534253425.0119.4119.4The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
55668343417.0177.488.7Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
55768263413.00.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
55834123412.0111.3111.3Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
55968243412.0178.789.3Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
560102333411.0445.7148.6Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
56134043404.085.685.6Photoelectrochemical cells. M GratzelNature200111713540Yes
56234013401.078.878.8Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
56368003400.0176.288.1TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
56434003400.0119.0119.0Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
56533993399.078.678.6Calcium signaling. David E ClaphamCell200718083096No
566101813393.7199.966.6Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
56733863386.0126.9126.9The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
56833843384.080.880.8The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
569101523384.00.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
57033813381.087.387.3Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
57133803380.0158.8158.8Measurement of pain. E C HuskissonLancet19744139420Yes
57233803380.0107.7107.7Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
57333793379.065.065.0Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
57433793379.098.098.0Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
57533743374.082.382.3The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57633703370.070.170.1The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
57733633363.078.178.1T cell exhaustion. E John WherryNat Immunol201121739672No
57833583358.095.095.0The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
57933553355.098.698.6A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
58033533353.0139.8139.8Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
58167053352.5322.4161.2Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
58233483348.0143.3143.3Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
58333473347.072.872.8TGFbeta in Cancer. Joan MassagueCell200818662538No
58433453345.093.193.1ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
58566883344.0188.794.3Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
58633423342.071.171.1Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
58733333333.086.186.1Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
588133253331.2513.1128.3APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
58933273327.0128.9128.9Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
59033033303.086.586.5Gene regulation by steroid hormones. M BeatoCell19892644044No
59133003300.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
59232993299.0146.0146.0Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
593131953298.8408.2102.0Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
59432953295.064.464.4Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
59532953295.071.871.8Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
59632853285.075.275.2Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
59798463282.0260.987.0Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
59865623281.0186.893.4Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
59932733273.067.067.0STATs and gene regulation. J E DarnellScience19979287210No
60032733273.0118.5118.5The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
60132703270.069.269.2CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
60232683268.0150.5150.5The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
60332583258.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
60465053252.5158.979.5Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
60565043252.0118.459.2The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
60632463246.084.784.7MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
60732453245.096.696.6Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
608129793244.8309.877.5Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
60964763238.0144.872.4Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
61032383238.073.473.4Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
61132373237.083.583.5Obesity as a medical problem. P G KopelmanNature200010766250No
61264723236.0143.271.6Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
61332253225.074.674.6Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61432253225.091.491.4Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
61532123212.0142.6142.6Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
61696313210.3208.669.5Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
61764133206.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
61864043202.0157.578.8Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
61964023201.0209.6104.8Extracellular vesicles: exosomes, microvesicles, and friends. Graca Raposo, Willem StoorvogelJ Cell Biol201323420871No
62063963198.0147.473.7MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
62131873187.076.276.2Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
62231813181.076.476.4WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
62331813181.0101.6101.6Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
62431693169.0147.0147.0The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
62531683168.080.080.0The transforming growth factor-beta family. J MassagueAnnu Rev Cell Biol19902177343No
62631683168.0102.4102.4Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
62763083154.0216.9108.5Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
62894453148.3225.475.1The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62962963148.0195.397.7Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
63031473147.096.996.9Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
63131433143.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
63294273142.3323.1107.7Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
63394223140.7484.1161.4SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
63462783139.0138.969.5Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
63531393139.0135.3135.3What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
63631303130.0100.8100.8Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
63731303130.086.686.6Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
63831283128.0108.0108.0Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
63993803126.7323.5107.8Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
64031263126.0108.9108.9SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
64162433121.5188.894.4Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
642124813120.2312.578.1Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
64331173117.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
64493453115.0219.273.1TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
64593333111.0389.9130.0Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
64631103110.064.164.1Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64730993099.075.075.0Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
64830943094.098.798.7Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
64930873087.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
65061483074.0202.3101.2Tissue engineering. R Langer, J P VacantiScience19938493529No
65130713071.073.073.0Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
65230703070.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
65330673067.082.582.5Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
65430663066.089.489.4Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
65561263063.0240.7120.3The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
65630623062.0103.7103.7An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
65761213060.5240.2120.1Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
65830603060.058.658.6RNA interference. Gregory J HannonNature200212110901No
65930533053.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa Radiol (Stockh)195313057644Yes
66030513051.064.064.0Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
66130443044.062.662.6Papillomaviruses and cancer: from basic studies to clinical application. Harald Zur HausenNat Rev Cancer200212044010No
66260843042.0200.8100.4Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66330403040.079.779.7Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
66491143038.0189.263.1Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
66530383038.079.479.4Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
66630353035.085.485.4The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
66730343034.089.889.8The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
66830323032.073.973.9Structure and function of telomeres. E H BlackburnNature19911708110No
66930293029.083.083.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
67060513025.50.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
67160493024.5162.781.3Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
672180943015.7413.168.9Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
67330143014.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
67490363012.0214.671.5Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
67530103010.067.367.3Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
67659982999.0137.868.9The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
67789722990.7394.8131.6Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
67829862986.0114.5114.5Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
67929862986.0119.8119.8Metazoan MicroRNAs. David P BartelCell201829570994No
68059712985.5127.063.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
68129842984.096.896.8Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
68259682984.0205.2102.6The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
68329832983.057.857.8Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68429832983.090.790.7Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
68529752975.064.864.8Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
68629752975.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
68759502975.0142.471.2Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
68829732973.045.145.1A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
68929662966.059.459.4Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
69029652965.074.374.3P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
69129622962.091.691.6Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
69288802960.0255.885.3Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
69359182959.0136.468.2Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
69429562956.056.456.4Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
69529562956.0192.2192.2User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
69659092954.5174.887.4Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69729522952.052.052.0Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
69829502950.090.890.8Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
69929502950.067.967.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
70029502950.074.074.0An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
70188412947.0274.491.5Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
70288322944.0257.285.7Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
70329432943.062.362.3Principles of CDK regulation. D O MorganNature19957877684No
70429422942.0116.9116.9UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
70529372937.079.879.8Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
70629342934.068.268.2Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
70729332933.071.971.9Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
70858632931.5187.193.5Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
70987772925.7246.582.2trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni GabaldonBioinformatics200919505945Yes
71029232923.093.793.7Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
71158372918.5263.2131.6Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
71229182918.0156.9156.9Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
71387522917.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
71458332916.5116.858.4Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
715466492915.61489.393.1Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
71629132913.079.979.9Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
71787372912.3248.882.9Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
71829122912.071.471.4Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
71958242912.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
72058232911.5168.384.2Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
72129112911.0102.2102.2Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
72258222911.0203.5101.8A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
72329092909.097.297.2A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
72429082908.0134.4134.4Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
72529052905.0130.5130.5Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
72658042902.0154.977.5Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
72729022902.075.575.5A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
72829012901.062.962.9Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
72929012901.0112.1112.1Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
73028992899.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
73157972898.5139.069.5A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
73228982898.067.367.3Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
73328922892.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
73457782889.0190.195.0PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
73528862886.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BoyumScand J Clin Lab Invest Suppl19685707208Yes
73657712885.5164.082.0Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
737115302882.5299.975.0Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
73828792879.051.451.4One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
73928672867.078.578.5Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
74085962865.3228.276.1Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
74157222861.0197.898.9Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
74228612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
74357162858.0151.375.7ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
74428572857.072.572.5Memory--a century of consolidation. J L McGaughScience200010634773No
74585572852.3240.880.3Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
74628522852.077.777.7A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
74757032851.5213.0106.5Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
74857022851.0119.059.5Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
74928442844.084.784.7A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
75028442844.0117.8117.8Deep learning in neural networks: an overview. Jurgen SchmidhuberNeural Netw201525462637No
75128382838.067.367.3Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
75228362836.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
75328362836.069.069.0Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
75428342834.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
75528342834.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
75656632831.5139.569.8Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
75756612830.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
75856602830.00.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
75956592829.5156.978.5UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
76028282828.068.468.4Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
76156542827.0140.670.3Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
76256502825.0154.777.3Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
76356382819.0188.594.2Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
76456342817.00.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
76528162816.070.470.4MYC on the path to cancer. Chi V DangCell201222464321No
76628162816.0121.4121.4The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
76728152815.054.754.7Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
76828142814.084.384.3Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
76984382812.7215.171.7RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
77028122812.058.958.9On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
77128122812.083.083.0Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
77256222811.00.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
773112422810.5385.896.5Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
77456122806.0153.476.7The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
77556052802.5134.167.0Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
77628022802.056.856.8The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
777112072801.8345.886.5Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
77827992799.069.369.3Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
77955912795.5173.286.6Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
78055902795.0205.8102.9A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
78127952795.064.664.6Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
78255802790.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
783111412785.2292.073.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
78427842784.061.161.1The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
78527812781.077.877.8Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
78655602780.0130.065.0Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
78755552777.5151.275.6A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
78827772777.085.485.4Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
78927772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
79027702770.079.479.4Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
79155372768.5118.559.2MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
79227662766.061.561.5Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
79327652765.068.768.7Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
79427652765.0144.6144.6The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
79555272763.5112.356.1Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
79627632763.086.086.0Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
79727632763.061.561.5Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
79855242762.0259.9129.9Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
79955202760.0167.183.5Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
80027572757.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
80127552755.060.160.1Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
80255082754.0188.594.2SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
80327462746.065.165.1The inflammatory reflex. Kevin J TraceyNature200212490958No
80454892744.5112.356.1High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
805109602740.0253.763.4MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-Ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
80682152738.3348.7116.2The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M Van Stralen, Robert WestImplement Sci201121513547No
80727312731.087.787.7PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
80827302730.054.454.4Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
80927282728.069.169.1Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
81054522726.0294.4147.2OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
81127222722.096.596.5Working memory. A BaddeleyScience19921736359No
81254422721.0188.994.5The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
81327212721.090.690.6What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
81481542718.0174.258.1Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
81527172717.0147.6147.6Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
81627152715.080.280.2Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
817108542713.5291.272.8GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David Van Der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
818108482712.0239.960.0Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
81954212710.596.748.4A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
82054172708.5139.869.9The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
82127062706.073.373.3Dominant forces in protein folding. K A DillBiochemistry19902207096No
82227012701.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
82326992699.067.667.6Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
82426982698.070.270.2Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
82526982698.0147.4147.4Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
82626902690.060.460.4Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
82726892689.0129.6129.6Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82826892689.0107.9107.9Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
82926832683.096.096.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
83080452681.7218.672.9MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
83153572678.5145.772.8Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
83226702670.068.768.7The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
83326622662.098.798.7Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
83426612661.073.373.3TGFβ signalling in context. Joan MassagueNat Rev Mol Cell Biol201222992590No
83526602660.078.278.2Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
83679772659.0251.683.9Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
837132902658.0326.965.4Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
83853082654.0121.360.6Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
83953062653.0115.157.5Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
84026502650.081.981.9The biology of oxygen radicals. I FridovichScience1978210504Yes
84152882644.0185.792.8Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rossello-MoraProc Natl Acad Sci U S A200919855009Yes
84252712635.5108.354.1Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
84326342634.0111.3111.3The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
84452682634.0158.779.3The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
84552662633.0147.673.8Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
84626312631.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
84726302630.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
84826292629.0100.5100.5Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
84952572628.5172.386.2The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
850209852623.1843.8105.5The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver GlocknerNucleic Acids Res201323193283Yes
85126222622.088.288.2Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
85252442622.0190.895.4Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
85352432621.5118.759.4Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
85452422621.00.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
85526152615.079.479.4A two process model of sleep regulation. A A BorbelyHum Neurobiol19827185792Yes
85626142614.079.979.9Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
85726132613.051.751.7Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
85852242612.0167.683.8A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
85926092609.075.375.3Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
86026062606.079.379.3Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
86126052605.096.296.2Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
86252052602.5168.684.3The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
86352012600.5182.491.2Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
86452012600.50.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
86525972597.056.656.6G1 phase progression: cycling on cue. C J SherrCell19947954821No
86651932596.5148.474.2Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86725962596.082.882.8Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
86825942594.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
869103612590.2403.4100.8Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
87025872587.074.074.0Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
87125872587.067.767.7The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
87251682584.0148.874.4Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
87351632581.5165.282.6Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
87425812581.067.967.9The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
87525802580.084.084.0Hazards of heavy metal contamination. Lars JarupBr Med Bull200314757716No
87651462573.0153.376.7Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan Van Eck, Ludo WaltmanScientometrics201020585380Yes
87725702570.091.991.9The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
87825702570.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
87951292564.5213.4106.7A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
88051262563.0209.2104.6Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
88125622562.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
88225612561.094.994.9Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
88325602560.051.851.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
88425602560.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
885102382559.5215.153.8WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
88676752558.3286.895.6Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
88725582558.068.668.6Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
88851142557.0176.288.1Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
88925572557.0116.2116.2International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
89051102555.0242.5121.2Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
89125542554.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
89225532553.055.555.5Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
89351052552.5126.563.2Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H Von HippelAnal Biochem19892610349Yes
894101962549.0493.5123.4The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
89525482548.047.247.2Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
89625452545.069.269.2Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
89750882544.0139.069.5Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
89825442544.064.364.3The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
89925382538.061.461.4Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
90025372537.073.373.3Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
90150722536.0165.882.9Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
90250682534.0148.574.2Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
903101352533.8238.659.6Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G Von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
90450672533.5102.551.2CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
90575792526.3269.089.7Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
90625262526.058.858.8Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
90725252525.0108.7108.7Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
90825242524.066.366.3Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
90925232523.077.677.6Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
91050452522.5137.768.8Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
91125222522.093.693.6Human error: models and management. J ReasonBMJ200010720363Yes
91225222522.047.047.0Wnt signaling and cancer. P PolakisGenes Dev200010921899No
91325212521.0149.3149.3The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
91425202520.062.762.7Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
91525202520.056.656.6A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
91650362518.0117.758.9Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
91725172517.077.077.0Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
91825132513.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
91925112511.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
92025112511.045.945.9Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
92150172508.5187.593.8mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
92225082508.079.879.8Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
92350142507.0113.756.9AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
92425042504.075.075.0Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
92574992499.7171.157.0The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
92649982499.0126.063.0Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
92749912495.5100.750.4The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
92849762488.0139.869.9Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
92974612487.0249.283.1Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
93024862486.089.089.0Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
93149672483.5103.551.8Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
93224812481.049.049.0Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
93324812481.057.757.7Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
93424792479.072.672.6The importance of selenium to human health. M P RaymanLancet200010963212No
93524792479.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
93649562478.0134.467.2A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
93724712471.086.786.7Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
93824702470.055.355.3Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
93924672467.052.052.0The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
94049322466.0175.287.6Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
94149312465.5120.760.4Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
94224642464.080.880.8Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
94349262463.0144.672.3Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
94473862462.0229.876.6The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
94524602460.087.487.4Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
94624542454.057.657.6Specification of cerebral cortical areas. P RakicScience19883291116No
94724512451.065.465.4Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
94824472447.0119.3119.3Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
94948942447.0203.9102.0Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
95048922446.0128.764.3The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
95148912445.5135.367.7Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
95224452445.055.755.7Social controls on cell survival and cell death. M C RaffNature19921557121No
95348892444.5266.6133.3ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
95448882444.0189.594.8The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
95548832441.5179.889.9ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
95624402440.080.780.7Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JobsisScience1977929199Yes
95724402440.056.556.5Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
95824372437.053.853.8NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
95924342434.066.766.7A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
96048682434.0106.253.1New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
96124332433.053.653.6Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
96248662433.0208.3104.2Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
96348642432.097.148.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassagueCell200312809600No
96497242431.0244.061.0Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
96548552427.5132.266.1Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
96648532426.5150.275.1Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
96724252425.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
96824182418.0101.2101.2Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
96924172417.057.157.1A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
97072512417.00.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
97148322416.00.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
97224142414.062.462.4Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
97324142414.082.982.9A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
97424142414.0209.3209.3Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Brent R StockwellCell202235803244No
97572352411.7246.682.2Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
97648232411.5133.266.6Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
97772342411.3207.569.2Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
97848192409.5138.969.5Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
97948182409.0105.252.6Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
98024092409.052.252.2Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
98124062406.074.574.5The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
98248092404.5128.964.5Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
98348072403.5204.7102.3The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
98448032401.591.946.0A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
98548032401.5126.663.3The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
98624012401.049.849.8The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
98723972397.051.751.7Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
98823972397.080.880.8Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
98923952395.095.395.3The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
99023952395.083.083.0Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
99123952395.072.872.8Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
99223942394.054.654.6Theta oscillations in the hippocampus. Gyorgy BuzsakiNeuron200211832222No
99347832391.5184.492.2Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
99423912391.045.645.6Shelterin: the protein complex that shapes and safeguards human telomeres. Titia De LangeGenes Dev200516166375No
99571612387.0156.452.1EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
99647712385.50.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99723822382.088.188.1Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
99823812381.069.169.1phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
99923792379.083.383.3Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
100047542377.0210.9105.5A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
1001261392376.3676.261.5PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W De Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
100247522376.092.646.3SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
100347452372.5212.6106.3The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
100447442372.0109.454.7Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
100523712371.077.277.2Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
100623692369.071.971.9Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
100771002366.7177.959.3APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
100823652365.078.678.6A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
100923652365.079.779.7Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
101023632363.052.752.7Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
101147212360.50.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
101223602360.060.760.7A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
101347192359.586.443.2The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
101423592359.060.860.8RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
101523582358.089.489.4Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
1016188412355.1593.874.2The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
101723552355.053.253.2The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
101823522352.056.556.5The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
101923502350.044.944.9Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
102023492349.062.862.8Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
102123472347.060.160.1Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
102223452345.069.669.6Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
102323452345.062.862.8Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
102423452345.070.870.8Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
102546882344.0120.160.0A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
102623442344.0104.8104.8Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
102746812340.5121.360.6Building better batteries. M Armand, J M TarasconNature200818256660No
102870122337.3211.170.4Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
102946702335.0101.951.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
103046682334.0183.191.5Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
103123322332.054.954.9A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
103269952331.7198.166.0Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdottir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
103323312331.097.497.4Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
103423312331.077.977.9Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
103546612330.5100.450.2Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
103623302330.077.177.1Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
103746602330.0213.2106.6Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
103846592329.5130.265.1Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
103923272327.0119.4119.4Subjective well-being. E DienerPsychol Bull19846399758No
104023272327.075.375.3Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
104123272327.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
104223262326.066.066.0What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
104323222322.066.366.3Descending control of pain. Mark J MillanProg Neurobiol200212034378No
104423212321.062.962.9Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
104546412320.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
104646392319.5125.562.8Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
104746392319.5104.252.1The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
104823172317.066.766.7Hybrid porous solids: past, present, future. Gerard FereyChem Soc Rev200818197340Yes
104946322316.0112.856.4Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
105046282314.093.446.7Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
105146202310.0190.095.0The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
105223082308.071.571.5Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
105346162308.00.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
105423082308.059.759.7Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
105523042304.059.259.2Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
105623042304.058.558.5Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
105723032303.051.751.7Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
105823022302.059.159.1Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gokhan S HotamisligilCell201020303879No
105992072301.8379.094.8jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramon Doallo, David PosadaNat Methods201222847109Yes
106045902295.0140.670.3EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F De CharroAnn Med200111491192No
106122942294.052.152.1Complement. First of two parts. M J WalportN Engl J Med200111287977No
106222912291.055.355.3Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
106322882288.077.477.4Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
1064114392287.8372.874.6The hallmarks of aging. Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
106522862286.0100.9100.9The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
106622832283.080.980.9Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
106722832283.045.345.3SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
106822832283.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
106922812281.066.366.3Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
107022782278.065.665.6Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
107168312277.0224.874.9Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris Sherman, Hepatology201121374666No
107245532276.5173.386.7ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
107322762276.054.254.2Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
1074136512275.2312.452.1NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
107522742274.070.770.7Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
107622732273.090.590.5Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
107745452272.587.343.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
107822712271.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LoeJ Periodontol19675237684Yes
107945412270.5146.173.0A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y K XiePain19882837713Yes
1080158902270.0484.869.3AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
108122702270.089.389.3Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
108245372268.5106.253.1Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
108322682268.060.660.6The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
108445362268.0110.855.4Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
1085158652266.4498.871.3The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, Lancet200718064739Yes
108645322266.0142.971.5Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
108745312265.590.145.0Network biology: understanding the cell's functional organization. Albert-Laszlo Barabasi, Zoltan N OltvaiNat Rev Genet200414735121No
108822612261.058.258.2Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
108922592259.046.746.7Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
109045182259.00.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E Till, E A McCULLOCHRadiat Res196113776896Yes
109122592259.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
109222572257.056.556.5Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
109345112255.5113.156.5Neuronal oscillations in cortical networks. Gyorgy Buzsaki, Andreas DraguhnScience200415218136No
109422532253.091.791.7Perception of risk. P SlovicScience19873563507Yes
109522532253.055.555.5Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
109645062253.0101.150.5ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
109745012250.5159.079.5The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
109822502250.088.688.6Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
109922502250.089.389.3International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
110022492249.060.360.3Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
110144972248.5104.652.3A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
110222462246.057.457.4Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
110344912245.595.447.7'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
110489772244.2420.4105.1Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
110522432243.064.064.0Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
110622432243.079.579.5Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
110722422242.058.758.7Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
110822412241.077.677.6A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
110967172239.0238.179.4Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
111022382238.050.650.6The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
111122362236.067.967.9Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
111222342234.074.474.4Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
111389322233.0222.955.7Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
111422332233.081.981.9Selenium and human health. Margaret P RaymanLancet201222381456No
111522322232.095.995.9A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
111644642232.0105.652.8The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
111744552227.5131.065.5Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
111844542227.0138.569.2Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
111966812227.0414.8138.3Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
112044522226.098.649.3Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
112122262226.082.282.2AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
112288982224.5238.459.6Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
112322222222.054.654.6Mechanisms and genes of cellular suicide. H StellerScience19957878463No
112422212221.071.171.1Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
112522212221.089.489.4Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
112622202220.087.387.3Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
112744392219.5315.0157.5Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
112822192219.051.051.0Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
112966552218.3219.473.1Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
113044322216.0133.066.5Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
113166422214.0174.658.2GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
113222142214.080.480.4Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
113388522213.0307.576.9Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
113422112211.072.072.0The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
113544172208.586.143.0The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
113622082208.059.059.0Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
113744162208.0104.252.1Liver fibrosis. Ramon Bataller, David A BrennerJ Clin Invest200515690074No
113822072207.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
113966202206.7198.166.0Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
1140154472206.7442.663.2BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
114122062206.055.655.6Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
114222052205.055.455.4Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
114344102205.0184.092.0The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
114444092204.5134.067.0LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
114522042204.069.769.7Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
114622042204.051.551.5Chemokines. B J RollinsBlood19979242519No
114766122204.0179.459.8Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
114844072203.588.644.3Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
114922022202.086.086.0Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
115022022202.086.886.8α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
115144012200.5146.773.3Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
115221982198.0111.3111.3Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. Cynthia RudinNat Mach Intell201935603010Yes
115343942197.0108.854.4Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
115443922196.0200.0100.0Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
115521962196.073.773.7Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
115643902195.0169.584.8Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
115721932193.084.984.9Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
115821912191.071.471.4Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
115965732191.0279.093.0Shedding light on the cell biology of extracellular vesicles. Guillaume Van Niel, Gisela D'Angelo, Graca RaposoNat Rev Mol Cell Biol201829339798No
116043792189.5118.259.1Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
116121892189.048.448.4Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
116221862186.041.241.2NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
116365562185.3225.075.0Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
116443702185.0139.669.8Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes Da SilvaClin Neurophysiol199910576479No
116543702185.0240.9120.5Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
116643672183.5184.192.0The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683Yes
116721822182.043.643.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
116821792179.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
116943582179.0145.072.5Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
117087142178.5347.286.8The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerstromBr J Addict19911932883Yes
117165352178.3124.241.4Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
117221782178.044.344.3DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
1173108892177.8529.2105.8ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt Von Haeseler, Lars S JermiinNat Methods201728481363Yes
117421772177.046.446.4Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
117521752175.052.952.9The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
117621732173.049.349.3Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
117721732173.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
117843442172.00.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
117921702170.045.745.7Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
118021682168.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
1181151752167.9363.051.9Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
118243352167.5287.3143.7WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
118343342167.0141.870.9Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
118421662166.042.542.5Protein modules and signalling networks. T PawsonNature19957531822No
118521652165.058.658.6From sensation to cognition. M M MesulamBrain19989648540No
118621652165.046.546.5Molecular bases for circadian clocks. J C DunlapCell19999988221No
118721642164.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
118843242162.0110.455.2Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
118943232161.5104.652.3Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
119064822160.7295.398.4Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
119143162158.0191.996.0The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
119243122156.0131.865.9Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
119321562156.051.651.6Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
119443112155.5173.186.5The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
119521552155.0103.9103.9Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
119621552155.049.149.1Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
119721552155.085.685.6Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
119886182154.5356.789.2Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
119921532153.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
120064552151.7330.7110.2Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
120164532151.0216.772.2Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
120242952147.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
120364422147.3152.350.8MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WuthrichJ Mol Graph19968744573Yes
120421472147.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
120564402146.70.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
120621462146.067.467.4The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
120742912145.5113.856.9The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
120842902145.00.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
120921442144.046.846.8The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
121064272142.3273.591.2Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J McCann, E YamasakiMutat Res1975768755Yes
121142802140.088.144.0A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelieresJ Microsc200617210054Yes
121221392139.046.646.6TRP channels as cellular sensors. David E ClaphamNature200314654832No
121321362136.044.444.4DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
121421342134.064.564.5Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
1215170632132.9443.555.4Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
121642642132.0110.855.4Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
121721292129.093.293.2A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
121842582129.089.544.8Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
1219149012128.7348.749.8Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
122042542127.086.043.0The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
122121272127.069.669.6Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
122242532126.5126.763.4Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
122321262126.068.168.1Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
122484972124.2256.364.1Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
122521242124.045.445.4Mammalian G1 cyclins. C J SherrCell19938513492No
122642462123.084.842.4Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
122721232123.078.878.8The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
1228169822122.8599.074.9GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, BMJ200818436948Yes
122921212121.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
1230127252120.8313.752.3GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
123184782119.50.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
123221192119.067.867.8Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
123321192119.050.950.9DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
123421182118.050.550.5Patterns of amino acids near signal-sequence cleavage sites. G Von HeijneEur J Biochem19836852022Yes
123521172117.058.158.1Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
123642332116.594.047.0Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
123742312115.5105.652.8Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
123821152115.078.278.2Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
123921152115.058.758.7Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
124021152115.050.550.5The genetics of ageing. Cynthia J KenyonNature201020336132No
124121132113.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
1242105642112.8482.296.4Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L SalzbergNat Biotechnol201931375807Yes
124342242112.0105.452.7Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
124463342111.3202.267.4Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
124542222111.098.949.5Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
124621112111.041.741.7Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
124721112111.058.558.5What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
124842222111.0118.759.4Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
124942212110.5111.956.0ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
125042202110.0134.667.3Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
125142192109.5111.956.0Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
125242182109.0146.473.2The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
125321052105.055.655.6Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
125421042104.074.874.8Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
125521032103.062.262.2Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
125621012101.059.859.8The inverse care law. J T HartLancet19714100731Yes
125721012101.043.243.2Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
125821012101.059.959.9The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
125942012100.586.443.2An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
126063002100.0215.871.9AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
126141992099.5182.991.5Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
126220962096.041.341.3Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
126341912095.5147.673.8Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
126420942094.088.988.9The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
126520942094.042.842.8Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
126620942094.055.955.9Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
126741872093.5164.682.3The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
126820932093.056.956.9The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
126920922092.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
127020912091.052.252.2Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
127141802090.0122.161.0Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
127220892089.073.473.4Social relationships and health. Sheldon CohenAm Psychol200415554821No
127320882088.055.155.1Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
127420882088.0103.8103.8DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
127520862086.061.161.1ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
127641692084.5115.457.7New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
127720842084.062.562.5Introduction and General Overview of Cyclodextrin Chemistry. Jozsef SzejtliChem Rev199811848947Yes
127820822082.050.050.0Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
127920812081.086.986.9Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
128020812081.0143.1143.1The changing landscape of atherosclerosis. Peter LibbyNature202133883728No
128120802080.066.166.1Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
128262372079.0253.484.5Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C De Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
128341582079.0121.760.9The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
128441542077.0100.350.1Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
128520772077.091.091.0A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
128620772077.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
128720752075.036.536.5Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
128862252075.0196.265.4Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
128982972074.2246.161.5Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
129020742074.071.071.0The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
129141472073.599.749.9Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
129220732073.036.336.3ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
129320732073.059.059.0Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
129420722072.061.161.1Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
129520722072.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
129641432071.5157.278.6Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
129720712071.041.541.5Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
129862122070.7435.3145.1Ferroptosis: mechanisms, biology and role in disease. Xuejun Jiang, Brent R Stockwell, Marcus ConradNat Rev Mol Cell Biol202133495651No
129920702070.057.657.6Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
130020692069.043.343.3G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
130141352067.5111.755.9Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
130241352067.5111.155.5Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
130362022067.3133.444.5Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
130441342067.0115.757.9Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
130520662066.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
130661982066.0199.066.3SCANPY: large-scale single-cell gene expression data analysis. F Alexander Wolf, Philipp Angerer, Fabian J TheisGenome Biol201829409532Yes
130720652065.081.081.0Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
1308123902065.0379.663.3New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
130941292064.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
131020642064.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
131120632063.060.460.4Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
131220602060.060.760.7Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
1313185392059.9614.468.3The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
131441192059.5101.150.5The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
131541192059.5138.969.5Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
131641162058.0111.855.9Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
1317267402056.91049.380.7Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, Genet Med201525741868Yes
131841132056.589.244.6A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
131920562056.063.563.5Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
132020562056.061.261.2Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
132182192054.8203.550.9Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
132220542054.046.046.0A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
132320532053.072.972.9The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
132420522052.062.462.4Protein oxidation and aging. E R StadtmanScience19921355616No
132520522052.0119.5119.5A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
132620512051.056.656.6Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
132741022051.0122.861.4The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
132820512051.064.164.1Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
132920502050.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
133020472047.041.441.4The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
1331122742045.7395.665.9Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
133240902045.099.249.6Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
133340762038.0118.359.1CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
133420372037.048.148.1Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
133520372037.059.459.4The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
133620372037.062.662.6The role of senescent cells in ageing. Jan M Van DeursenNature201424848057No
133740732036.5152.076.0Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
133820362036.043.443.4Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
133920362036.046.946.9Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
134040682034.0126.763.4New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
134120342034.049.449.4Calcium signaling. D E ClaphamCell19957834745No
134220332033.063.563.5The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
134320322032.037.937.9In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
134440632031.5106.553.2Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
134540622031.0122.961.5A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
134620312031.049.649.6The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
134720312031.0112.2112.2Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
134840612030.5101.951.0Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
134920302030.073.973.9A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
135020302030.053.053.0Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
135140602030.0130.165.0Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
135220292029.088.888.8Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
135340572028.584.742.4A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
135420282028.053.453.4Purinergic nerves. G BurnstockPharmacol Rev19724404211No
1355101372027.4246.449.3Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
135620262026.057.857.8Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
135720262026.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
135820242024.064.364.3Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
135920222022.070.070.0Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
136020222022.045.545.5The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
136180842021.0325.681.4A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
136240422021.088.544.2Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
136320202020.064.264.2Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
136420192019.040.940.9CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
136520192019.051.451.4Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
136640372018.5119.459.7How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
136780702017.5317.179.3QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
136820162016.046.246.2Exploring complex networks. S H StrogatzNature200111258382No
136920152015.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
137040282014.091.245.6Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
137120142014.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
137220142014.037.037.0Signaling--2000 and beyond. T HunterCell200010647936No
137340252012.599.249.6PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schuttelkopf, Daan M F Van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
137440232011.591.545.8Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
137540202010.089.744.9The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
137640172008.5407.9203.9Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Luke A McGuinness, Julian P T HigginsRes Synth Methods202132336025Yes
137720082008.044.044.0XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
137820072007.044.644.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
137940132006.5115.257.6Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
138080212005.2346.786.7An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
138120052005.057.357.3The biology of interleukin-6. T KishimotoBlood19892473791No
138240092004.593.246.6Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
138320032003.076.076.0Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
138420022002.075.575.5Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
138520002000.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
138620002000.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
138719991999.078.178.1The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
138819991999.043.843.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
138939981999.0100.450.2The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
139019991999.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
139119981998.041.441.4Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
139219961996.059.759.7The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
139359881996.0195.065.0Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H Bastien, A Vallieres, C M MorinSleep Med200111438246Yes
139459851995.0112.037.3Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
139519941994.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
139619941994.056.056.0Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
139739881994.0145.072.5Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
139839881994.0113.256.6Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
139959821994.0343.0114.3An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
140059811993.7157.152.4Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
140139871993.5118.459.2Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
140219931993.042.742.7The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
140339861993.00.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
140419931993.073.573.5Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
140519921992.064.764.7Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
140639831991.5106.353.1The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
140759731991.0212.070.7Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
140819891989.073.773.7Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
140919861986.068.668.6Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
141019851985.051.351.3Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
141139701985.0123.561.8Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
141239681984.086.143.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
141319821982.060.960.9Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141419821982.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
141519821982.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
141619821982.045.845.8Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
141719811981.056.556.5Multiple imputation of discrete and continuous data by fully conditional specification. Stef Van BuurenStat Methods Med Res200717621469Yes
141819811981.076.076.0Antibiotics in the aquatic environment--a review--part I. Klaus KummererChemosphere200919185900No
141919801980.048.448.4The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
142019801980.0218.8218.8Epidemiology of chronic kidney disease: an update 2022. Csaba P KovesdyKidney Int Suppl (2011)202235529086No
142119791979.074.374.3Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
142219791979.060.360.3Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
142319791979.046.146.1Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
142439521976.0103.751.9Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
142519751975.049.649.6The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
142639491974.5128.064.0Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
142719721972.044.144.1Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
142839421971.0233.7116.8An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
142939391969.597.648.8Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
143019691969.060.160.1Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
143139371968.581.240.6Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
143219671967.049.649.6The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
143319671967.060.160.1Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
143459011967.0175.258.4Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RohlMol Biol Evol199910331250Yes
143519671967.059.359.3Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
143639331966.594.947.5Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
143719661966.059.259.2Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
143819661966.051.451.4Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
143939321966.0127.763.9Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
144019651965.089.789.7Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
144119651965.052.152.1The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
1442137541964.9534.476.3Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
144319631963.058.258.2Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
144439251962.5118.759.4Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
144519621962.059.459.4Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
144639221961.073.836.9Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
144719611961.042.642.6The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
144839191959.579.239.6Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
144978311957.8260.465.1The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
145078121953.0258.764.7cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Ali Punjani, John L Rubinstein, David J Fleet, Marcus A BrubakerNat Methods201728165473Yes
145119511951.044.044.0Signal sequences. The limits of variation. G Von HeijneJ Mol Biol19854032478Yes
145219511951.037.337.3Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
145319511951.046.146.1Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
145419511951.055.055.0The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
145539011950.5148.974.5Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
145619501950.077.477.4Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
145738991949.595.447.7Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
145819491949.043.543.5Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
145938971948.5152.376.2Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
146038971948.5129.864.9miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
146119481948.048.448.4Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
146258441948.0127.742.6A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
146319481948.056.056.0The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
146419461946.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
146519461946.034.934.9The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
146658381946.0140.746.9Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
146719451945.048.748.7Tricine-SDS-PAGE. Hermann SchaggerNat Protoc200617406207Yes
146858341944.7180.260.1Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
1469136101944.3471.267.3The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, J Clin Epidemiol200818313558Yes
147019441944.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
147158301943.3124.141.4Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
147219421942.048.448.4Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
147319411941.085.085.0Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
147438811940.596.748.4Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
147597011940.2362.972.6UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
147619401940.059.259.2Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
147719401940.065.265.2A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
147819391939.067.267.2Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
147919391939.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
148019371937.041.341.3Oxidative stress shortens telomeres. Thomas Von ZglinickiTrends Biochem Sci200212114022Yes
148138711935.5132.566.2Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
148296631932.6227.945.6Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
148338651932.5106.653.3Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
1484115941932.3320.953.5A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
148519321932.048.748.7Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
148619321932.051.751.7DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
148719321932.086.486.4Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
148819311931.053.753.7Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
148919301930.063.563.5The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
149038591929.5140.070.0Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
149177161929.0195.548.9p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
149219291929.048.948.9Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
149319281928.068.068.0Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
149419261926.090.290.2Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
149519251925.067.567.5The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
149619241924.046.346.3The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
149738471923.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
149819231923.036.336.3Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
149919201920.029.229.2Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
150019201920.062.862.8Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
150138371918.5202.2101.1Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
150257541918.0160.153.4A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
150319141914.053.253.2A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
150419141914.066.766.7The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
150519131913.048.048.0DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
150638261913.0109.854.9Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
150719121912.053.453.4In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
150838241912.088.344.1Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
150938231911.5116.958.5The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
151057341911.3260.286.7Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
151119091909.047.447.4Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
151219091909.042.942.9The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
151319091909.047.347.3Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
151419081908.053.453.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
151519071907.042.442.4The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
151638141907.093.947.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
151719061906.061.761.7Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
151819051905.073.073.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
151919051905.040.240.2Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
152095231904.6405.381.1BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
152138091904.586.443.2Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
152219041904.073.973.9Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
152319041904.049.549.5Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
152438041902.0149.374.7The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
152519021902.044.344.3The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
152638021901.0155.677.8Interpreting findings from Mendelian randomization using the MR-Egger method. Stephen Burgess, Simon G ThompsonEur J Epidemiol201728527048Yes
152757011900.3139.046.3A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
152819001900.090.290.2Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
152919001900.039.139.1Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
153019001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
153118991899.043.943.9Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
153218991899.095.295.2Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
153337971898.582.841.4Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
153475921898.0256.864.2Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
153518981898.052.552.5Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
153618981898.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
153718971897.049.149.1Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
153818971897.036.036.0Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
153918961896.040.840.8Points of control in inflammation. Carl NathanNature200212490957No
154018961896.050.750.7Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
154118961896.056.456.4Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
154237911895.5116.758.4Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
154318951895.065.965.9An overview of brominated flame retardants in the environment. Cynthia A De WitChemosphere200211999784No
154418951895.037.137.1Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
154518951895.067.467.4A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
154637861893.080.440.2Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
154718931893.041.741.7Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
154837861893.081.040.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
154937851892.593.346.6An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
155037851892.591.245.6Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
155118921892.048.148.1The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
155237811890.5101.951.0A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
1553207911890.1549.550.0The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
155418901890.077.577.5Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
155518881888.048.548.5Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
155637761888.00.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
155718881888.078.278.2Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
155837761888.0148.974.5MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
155975481887.0279.269.8FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
156018861886.038.738.7MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
156194291885.8373.774.7Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. J B Saunders, O G Aasland, T F Babor, J R De La Fuente, M GrantAddiction19938329970Yes
156237711885.5111.355.6Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
156337691884.5111.555.8The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
156475371884.2230.357.6Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
156537681884.0129.164.5Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156637651882.5151.375.7Assays of glutathione peroxidase. L Flohe, W A GunzlerMethods Enzymol19846727659Yes
156737641882.0128.764.3Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
156818821882.071.271.2Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
156956461882.0146.248.7Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
157037641882.0127.763.9Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
157175271881.8188.647.1Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
157218791879.038.838.8The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
157318781878.079.179.1Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
157418761876.060.660.6Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
157518761876.048.448.4Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
157618761876.039.439.4Protein homology detection by HMM-HMM comparison. Johannes SodingBioinformatics200515531603Yes
157718741874.061.961.9Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
157856211873.7151.150.4The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
157918731873.056.956.9A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
158093601872.00.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
158118721872.071.071.0Inflammation, metaflammation and immunometabolic disorders. Gokhan S HotamisligilNature201728179656No
158218711871.039.339.3A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
158318711871.048.448.4External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
158418711871.079.979.9The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
158556071869.0111.437.1Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
158618691869.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
158718681868.052.952.9Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
158818681868.045.845.8PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
158918681868.087.687.6ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
159018671867.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
159118661866.045.345.3A revolution in optical manipulation. David G GrierNature200312917694No
159218651865.036.636.6Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
1593149181864.8426.653.3Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
159455931864.3135.545.2Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
159537281864.0120.560.2Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
159693181863.6247.549.5Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-Yuan HsuN Engl J Med200415385656Yes
159737261863.088.144.0The Fas death factor. S Nagata, P GolsteinScience19957533326No
159893141862.8269.053.8Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
159918621862.054.254.2Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
160037241862.099.950.0Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
160118621862.081.981.9When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
160293061861.2416.783.3CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
160318591859.053.953.9Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
160418591859.046.446.4Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
160518591859.041.341.3Perceptions of epigenetics. Adrian BirdNature200717522671Yes
160618591859.075.375.3Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
160718581858.050.850.8Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
160818581858.041.841.8Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
160974301857.5308.677.216S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
161018571857.063.663.6Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
161137141857.0116.658.3An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
161237121856.0146.873.4The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
161337111855.581.941.0Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
161418551855.042.842.8DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
161537081854.0111.255.6Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
161674151853.8261.665.4Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
161737061853.00.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
161837051852.5142.071.0The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
161918521852.072.472.4Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
162037041852.081.941.0Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
162118521852.099.199.1Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
162237021851.0119.259.6Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
162318501850.050.850.8Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
162418501850.069.369.3Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287Yes
162537001850.0161.180.5Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
162618481848.077.377.3Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
162773911847.8150.637.6Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
162818471847.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
162918471847.047.747.7Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
163018471847.040.140.1Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
163136931846.5107.153.5Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
163218461846.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
163336921846.087.843.9The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
163436921846.0108.854.4Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
163592271845.4327.865.6Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
163636891844.586.243.1Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J De VellisJ Cell Biol19806248568Yes
163773771844.2243.160.8A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
163818441844.064.264.2The crisis in antibiotic resistance. H C NeuScience19921509257No
163936881844.0100.850.4Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
164036871843.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
164118421842.068.468.4Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
164236831841.5179.689.8Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
164318411841.050.350.3Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
164418401840.046.346.3Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
164536781839.078.039.0Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
164636771838.5215.6107.8Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Helmut Sies, Dean P JonesNat Rev Mol Cell Biol202032231263No
164718381838.033.733.7The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
164818381838.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
164936741837.069.034.5The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
165018351835.032.032.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
165118351835.044.944.9New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
165255031834.3189.763.2A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
165318341834.043.043.0Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
165491671833.4342.768.5Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
165518331833.090.890.8The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
165618331833.057.957.9Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
165718321832.039.839.8Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
165818321832.041.941.9An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
1659219691830.8705.058.8A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, Ann Intern Med200919414839Yes
166018301830.053.253.2Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
166118301830.069.469.4Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
166218291829.038.838.8Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
166318281828.063.163.1Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
166418281828.064.464.4A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
166554831827.7136.745.6Membrane lipids: where they are and how they behave. Gerrit Van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
166618261826.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
166754761825.3133.744.6A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
166818251825.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
166936501825.0137.468.7The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
1670182441824.4589.258.9Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
167118241824.046.846.8Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
167254701823.3139.646.5Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck OrntoftCancer Res200415289330Yes
167336451822.587.743.9Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
167436411820.595.047.5Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
167518201820.079.979.9The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
167636401820.0120.160.0The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
167718191819.045.345.3Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
167836351817.5138.869.43D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
167918171817.033.733.7Why genes in pieces? W GilbertNature1978622185Yes
168018161816.040.440.4AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
168118161816.059.559.5Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
168272631815.8320.780.2NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
168336311815.590.745.4Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
168436301815.095.847.9Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
168518151815.077.477.4PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
168618141814.060.360.3Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
168718121812.053.453.4THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
168818121812.041.641.6Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
1689163011811.2560.262.2The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
169018111811.071.771.7Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
169118101810.062.962.9The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
169218071807.070.470.4Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
169336111805.590.045.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
169436111805.596.548.2The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
169518051805.061.261.2Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
169636091804.5106.053.0Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
169736081804.0143.871.9A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
169818031803.080.780.7Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
169936061803.089.945.0Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
170018031803.057.057.0Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
170118021802.064.764.7Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
170218021802.056.856.8The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
170318011801.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
170418011801.071.171.1Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
170518011801.048.248.2BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
170636011800.5138.169.0Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
170790011800.2341.568.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, J Clin Epidemiol200919631508No
170818001800.040.840.8Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
170917991799.083.383.3Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
171017991799.039.739.7The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
171117971797.061.361.3Serum albumin. T PetersAdv Protein Chem19853904348No
171253911797.0128.842.9Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
171317961796.033.233.2Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
171417961796.051.751.7Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
171517961796.057.157.1Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
171617961796.035.935.9The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
171717961796.063.363.3A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
171817951795.042.042.0Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
171953841794.7119.239.7An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
172017941794.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
172135881794.098.649.3Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
172235871793.596.948.5EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
172317931793.065.065.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
172435841792.0128.264.1Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
172517921792.065.265.2The case-crossover design: a method for studying transient effects on the risk of acute events. M MacLureAm J Epidemiol19911985444Yes
172617911791.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
1727107451790.8226.537.8Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
172817901790.035.935.9Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
172917901790.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
173035791789.5147.873.9A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
173117881788.042.542.5Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
173235741787.095.247.6The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
173317861786.052.652.6Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
173435711785.581.240.6Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
173517851785.041.241.2Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
173653551785.0174.258.1Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
173717851785.072.772.7A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
173817841784.047.747.7A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
173917831783.037.937.9An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
174035651782.595.847.9Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
174135651782.5107.954.0Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
174217821782.058.058.0The in vitro micronucleus technique. M FenechMutat Res200011113469No
174317821782.060.260.2PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
174435631781.5113.056.5Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
174571251781.2310.777.7The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
174635611780.596.948.5Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
174735601780.085.442.7Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
174835581779.0149.774.8Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
174917791779.042.342.3In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
175035561778.0125.462.7A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
175117781778.029.929.9Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
175217751775.063.363.3Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
175317751775.061.161.1The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
175435491774.578.439.2Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
175535491774.592.546.2Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
175635491774.5117.358.6Mendelian randomization: genetic anchors for causal inference in epidemiological studies. George Davey Smith, Gibran HemaniHum Mol Genet201425064373No
175735481774.0129.264.6Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
175835471773.5173.386.7The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
175988631772.6319.864.0Salmon provides fast and bias-aware quantification of transcript expression. Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl KingsfordNat Methods201728263959Yes
176017691769.030.430.4Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
176117691769.070.570.5Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
176235381769.0201.0100.5Osteoarthritis. David J Hunter, Sita Bierma-ZeinstraLancet201931034380No
176335371768.50.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
176435371768.576.238.1The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
176517681768.048.148.1Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
176635351767.5233.2116.6A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
176717671767.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
176817671767.076.776.7Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
176917661766.041.741.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
177035311765.594.347.1Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
177135311765.575.437.7Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
177217651765.069.769.7MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
177370571764.2177.044.2CHARMM-GUI: a web-based graphical user interface for CHARMM. Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil ImJ Comput Chem200818351591No
177417641764.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BaranyJ Gen Physiol19674227924Yes
177517621762.065.265.2Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
177617621762.051.051.0Surface plasmon resonance sensors for detection of chemical and biological species. Jiri HomolaChem Rev200818229953No
177717611761.043.343.3Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
177817601760.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
177970391759.8232.958.2SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Soren Brunak, Gunnar Von Heijne, Henrik NielsenNat Methods201121959131Yes
178017591759.056.256.2Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
178135181759.073.036.5The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
178217581758.041.341.3Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
178317581758.031.131.1Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
178470321758.0284.871.2Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Jack Bowden, George Davey Smith, Philip C Haycock, Stephen BurgessGenet Epidemiol201627061298Yes
178535151757.576.038.0A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FluggeAnal Biochem19846731838Yes
178617571757.049.149.1G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
178717571757.039.739.7The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SudhofNature19957791897No
178852681756.0217.472.5Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
178935121756.097.048.5Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
179017561756.039.339.3Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
179117561756.0150.3150.3COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
179217551755.056.656.6Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
179352641754.7296.999.0MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
179435091754.577.638.8Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio D'Adda Di FagagnaNat Rev Mol Cell Biol200717667954No
179517541754.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
179617531753.039.639.6Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
179770121753.0139.034.8Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
179817521752.071.671.6Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
179952561752.0115.238.4Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
1800105091751.5304.150.7Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
180117511751.052.552.5The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
180235021751.0108.954.5The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
1803105051750.8399.066.5Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
180452511750.3226.775.6The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
180570011750.2237.559.4Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior PachterNat Biotechnol201627043002Yes
180617501750.049.749.7Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
180752491749.7153.651.2Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
180834991749.593.846.9Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
180917491749.059.059.0Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
181017491749.0387.7387.7A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn. Tian LuJ Chem Phys202439189657Yes
181117481748.040.940.9Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
181234961748.0209.9105.0Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
181317481748.056.056.0The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
181417481748.035.835.8DNA in a material world. Nadrian C SeemanNature200312540916No
181534951747.577.638.8The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
181634941747.091.145.5CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
181734931746.5263.9131.9Gut microbiota in human metabolic health and disease. Yong Fan, Oluf PedersenNat Rev Microbiol202132887946No
181817461746.049.649.6Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
181934921746.077.538.8The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
182017461746.042.342.3Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
182134911745.581.740.9Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
182234911745.585.042.5Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
182317451745.032.532.5Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
1824174221742.2569.657.0The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
182552261742.0124.341.4Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C Kolb, M G Finn, K Barry SharplessAngew Chem Int Ed Engl200111433435Yes
182617421742.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
182752241741.3135.745.2Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
182834821741.077.838.9Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
182917401740.075.575.5The micronucleus test. W SchmidMutat Res197548190Yes
183017401740.058.358.3Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
183134801740.0117.358.6Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
183217401740.057.057.0A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
183317401740.053.353.3Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
183417391739.051.951.9The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
183552091736.3192.964.3Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
183617361736.032.732.7Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
183717361736.041.741.7Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
183817361736.050.950.9Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
183917351735.060.960.9Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
1840104081734.7324.754.1The Molecular Signatures Database (MSigDB) hallmark gene set collection. Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo TamayoCell Syst201526771021Yes
184134691734.594.347.1Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
184217331733.070.870.8Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
184317331733.031.831.8How eukaryotic transcriptional activators work. M PtashneNature19883050531No
184434651732.5113.656.8Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
184517321732.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
184617321732.043.043.0The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
184717321732.091.191.1Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
184817311731.066.266.2Cyclosporine. B D KahanN Engl J Med19892687689No
184917311731.039.539.5Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
185017301730.046.146.1The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
185117301730.067.567.51,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
185251871729.0115.638.5Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
185317291729.037.537.5Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
185469161729.0315.378.8Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron DoNat Genet201829686387Yes
185517291729.056.456.4ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Tristan Ian CrollActa Crystallogr D Struct Biol201829872003Yes
185617281728.046.446.4Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
185717281728.081.181.1Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
185817281728.048.048.0Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
185917271727.046.446.4Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
186017261726.037.737.7Neuronal calcium signaling. M J BerridgeNeuron19989697848No
186117251725.034.534.5Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
186217241724.051.051.0Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
186317241724.039.639.6Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
186417231723.092.492.4Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
186551661722.0216.172.0Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
1866103291721.5249.341.6Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O LotvallNat Cell Biol200717486113Yes
186717211721.043.743.7Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
186817211721.042.442.4Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
186951601720.0106.035.3T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
187017191719.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
187117171717.064.664.6Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerstromAddict Behav1978735910Yes
187217171717.040.940.9The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
187317161716.034.034.0Hox genes in vertebrate development. R KrumlaufCell19947913880No
187417161716.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
187517161716.043.643.6Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
187617161716.053.553.5Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
187717151715.036.836.8Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
187834281714.071.135.5Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
187968551713.8157.439.4Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
188034271713.5109.354.6Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
188117131713.068.168.1An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
188217131713.049.949.9Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
188317131713.048.748.7Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
1884119841712.0295.642.2Integrative genomics viewer. James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
188534231711.581.540.8The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
188634211710.5102.851.4Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
188734211710.50.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
188834211710.576.438.2Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
188917101710.061.361.3Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
189068361709.0234.058.5The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
189134171708.5103.351.6Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
189217081708.050.150.1Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
189334161708.0128.464.2Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
189434151707.5113.856.9Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
1895102431707.2242.540.4Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
189634141707.090.245.1The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
189734141707.086.343.1Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
189834131706.581.941.0Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
189934121706.0105.652.8What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
190017061706.033.333.3Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
190117051705.033.533.5Switching and signaling at the telomere. E H BlackburnCell200111572773No
190234101705.088.344.1Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
190317041704.051.551.5Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
190417041704.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
190517041704.040.040.0Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
190634071703.5117.058.5Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
190751101703.3186.662.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
190834051702.582.541.2The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
190917021702.045.745.7Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
191017021702.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
191117021702.042.042.0Upconversion and anti-Stokes processes with f and d ions in solids. Francois AuzelChem Rev200414719973Yes
191234041702.0123.061.5How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
191317021702.043.043.0Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
191417011701.057.457.4The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
191517011701.034.934.9Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
191634021701.0164.982.5Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
191733991699.5116.858.4Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
191816981698.042.142.1NADPH oxidase: an update. B M BabiorBlood199910029572No
191950931697.7142.647.5Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
192016971697.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
192116971697.056.256.2Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
1922101801696.7359.259.9Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
192350891696.3115.438.5Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
192416961696.046.146.1Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
192516951695.029.829.8RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
192616951695.054.954.9Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
192716931693.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
192816921692.047.147.1Integrins. E RuoslahtiJ Clin Invest19911985087No
192933841692.098.249.1Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
193016921692.044.744.7Fast and robust fixed-point algorithms for independent component analysis. A HyvarinenIEEE Trans Neural Netw199918252563Yes
193150751691.7144.348.1Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
193267661691.5350.887.7Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E HoltPLoS Comput Biol201728594827Yes
193316911691.045.745.7Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
193416911691.034.534.5Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
193516901690.055.555.5Metallothionein. D H HamerAnnu Rev Biochem19863527054No
193616901690.060.160.1Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
193716901690.076.076.0Mood and memory. G H BowerAm Psychol19817224324Yes
193833791689.5109.654.8An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
193916891689.041.741.7The molecular genetics of cancer. J M BishopScience19873541204No
194016891689.063.463.4Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
194150651688.3322.5107.5Correlation Coefficients: Appropriate Use and Interpretation. Patrick Schober, Christa Boer, Lothar A SchwarteAnesth Analg201829481436No
194216881688.066.766.7A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
194316881688.038.038.0Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
194467501687.5169.142.3Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
194550581686.0147.049.0How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
194684291685.8439.287.8Standards for reporting qualitative research: a synthesis of recommendations. Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A CookAcad Med201424979285Yes
194733701685.0125.762.9Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
194816851685.041.241.2A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
194933691684.5106.553.2Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
195016831683.039.639.6The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
195184131682.6331.866.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Int J Surg201020171303No
195216821682.032.732.7Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
195316821682.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
195416811681.068.668.6Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
195516811681.056.956.9Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
195616801680.036.536.5Sustainable hydrogen production. John A TurnerScience200415310892Yes
195733561678.097.949.0A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marcais, Carl KingsfordBioinformatics201121217122Yes
195816781678.052.752.7Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
195933551677.569.034.5NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
196033531676.580.340.1NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
196116761676.054.254.2Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
196216761676.083.083.0Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
196350271675.7123.441.1Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
196416751675.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
196516731673.054.054.0The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
196616731673.047.247.2Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
196733451672.573.536.8Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassagueCell200617110329No
196816721672.056.056.0Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
196916721672.044.144.1Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
197033431671.5120.160.0The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
197133431671.585.142.5Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
197216711671.033.233.2The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
197316711671.056.956.9The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FrohlichInt J Nanomedicine201223144561No
197416701670.063.863.8The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
197550091669.7165.155.0Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graca Raposo, Clotilde TheryAnnu Rev Cell Dev Biol201425288114No
197616691669.047.047.0Aspergillus fumigatus and aspergillosis. J P LatgeClin Microbiol Rev199910194462No
197716691669.040.440.4Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323Yes
197850071669.0102.634.2The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jurg TschoppMol Cell200212191486Yes
197916691669.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
198033381669.0131.165.5Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958Yes
198133371668.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
1982133471668.4353.944.2Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, N Engl J Med200211832527Yes
198333361668.0110.555.2MissForest--non-parametric missing value imputation for mixed-type data. Daniel J Stekhoven, Peter BuhlmannBioinformatics201222039212Yes
198416681668.050.750.7The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
198516671667.041.441.4Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
198616671667.049.949.9Bioactive microbial metabolites. Janos BerdyJ Antibiot (Tokyo)200515813176No
198733341667.080.740.4Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
198833321666.0114.757.4A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
198949961665.30.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
199016651665.062.262.2Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
199133301665.072.936.5Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
199233301665.070.935.5Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
199333301665.0139.169.5The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
199416641664.057.657.6Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
199533281664.00.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
199616641664.042.042.0Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
199716641664.056.556.5Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
199833281664.090.045.0Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
199933271663.573.736.9Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
200033261663.063.131.6The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
200116631663.048.548.5n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
200216631663.034.334.3The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
200333241662.092.646.3A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
200433231661.578.739.4A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
200533231661.5112.556.2Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
200616611661.071.571.5Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
200733221661.084.342.1Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
200816611661.038.338.3From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
200966421660.5299.975.0Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
201016601660.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
201116601660.045.045.0The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
201216601660.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
2013116161659.4398.757.0Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
201466371659.2155.338.8Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
201516581658.028.128.1Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
201616581658.032.232.2Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
201716581658.058.458.4Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
201833141657.080.540.2Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
201916571657.063.963.9SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
202016571657.040.440.4Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
202133141657.068.234.1Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
202216561656.066.066.0What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhaSoc Sci Med200919520474Yes
202316551655.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
202416551655.036.336.3DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
202566191654.8242.260.5MultiQC: summarize analysis results for multiple tools and samples in a single report. Philip Ewels, Mans Magnusson, Sverker Lundin, Max KallerBioinformatics201627312411Yes
202633081654.0154.077.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
202716541654.042.242.2The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
202816541654.058.758.7Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
202916531653.075.675.6The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
203016531653.031.131.1Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
203116531653.080.480.4Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Hae-Young KimRestor Dent Endod201323495371Yes
203233051652.5100.150.0Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
203316521652.055.455.4Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
203416521652.036.136.1Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
203516511651.036.436.4Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
203666041651.0166.741.7Universal sample preparation method for proteome analysis. Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
203716501650.029.229.2Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
203816501650.091.991.9Head and Neck Cancer. Laura Q M ChowN Engl J Med202031893516No
203932991649.5108.154.0Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E Barlow, Pediatrics200718055651Yes
204016491649.034.334.3Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
204132981649.083.841.9Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
204216481648.038.138.1Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
204316481648.031.531.5Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
204432961648.087.843.9Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
204598781646.3355.659.3StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L SalzbergNat Biotechnol201525690850Yes
204616461646.042.142.1Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
204716461646.041.341.3The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
204816451645.042.142.1Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
204916451645.044.944.9Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
205016451645.050.450.4Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
205116441644.032.132.1Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
205216441644.032.332.3Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
205332881644.087.243.6Abdominal obesity and metabolic syndrome. Jean-Pierre Despres, Isabelle LemieuxNature200617167477No
205498631643.8294.849.1TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
205532871643.570.635.3Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
205616431643.045.145.1Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
205749281642.7151.250.4The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
205832851642.596.448.2Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
205916421642.046.946.9Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
206016411641.037.737.7Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
206116411641.030.530.5Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
206216411641.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
206316401640.085.385.3Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
2064131151639.4364.345.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
206532781639.0107.453.7Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
206616381638.074.174.1Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
206716381638.055.355.3Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
206816381638.027.827.8Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
206916381638.039.039.0Thiazolidinediones. Hannele Yki-JarvinenN Engl J Med200415356308No
207032761638.073.036.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
207116371637.033.933.9RNA silencing in plants. David BaulcombeNature200415372043No
207216371637.046.346.3Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
207316371637.040.940.9Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
207449091636.3154.751.6The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
207516361636.074.674.6Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
207616361636.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
207732711635.586.343.1Obesity. David W Haslam, W Philip T JamesLancet200516198769No
207816351635.051.451.4Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
207932701635.079.139.5Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
208032701635.0116.358.1Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Christoph Hafemeister, Rahul SatijaGenome Biol201931870423Yes
208116341634.052.452.4Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
208216341634.048.448.4Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
208332661633.00.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
208448981632.7176.458.8Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
208516321632.050.950.9The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
208632631631.582.941.5Dali server: conservation mapping in 3D. Liisa Holm, Paivi RosenstromNucleic Acids Res201020457744Yes
208748941631.3263.887.9Improved metagenomic analysis with Kraken 2. Derrick E Wood, Jennifer Lu, Ben LangmeadGenome Biol201931779668Yes
208816311631.047.647.6The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinasScience19883059497No
208916311631.037.937.9Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
209032621631.0137.969.0AMPK: guardian of metabolism and mitochondrial homeostasis. Sebastien Herzig, Reuben J ShawNat Rev Mol Cell Biol201828974774No
209148921630.7128.642.9The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
209216291629.047.747.7Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
209332581629.055.927.9Mutations affecting segment number and polarity in Drosophila. C Nusslein-Volhard, E WieschausNature19806776413Yes
209432581629.069.234.6The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
209548831627.7101.233.7Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
209632551627.560.730.4Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
209716271627.037.337.3Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
209816261626.043.843.8Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
209916251625.049.449.4Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
210016251625.059.159.1Cell damage in the brain: a speculative synthesis. B K SiesjoJ Cereb Blood Flow Metab19816276420No
210164961624.0174.343.6Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
210232471623.5122.761.4Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
210332471623.5133.967.0Using Effect Size-or Why the P Value Is Not Enough. Gail M Sullivan, Richard FeinnJ Grad Med Educ201223997866Yes
210416231623.042.342.3Molecular biology of prion diseases. S B PrusinerScience19911675487No
210532461623.064.932.5Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
210616231623.054.054.0The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
210748671622.3131.443.8Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
210816221622.036.036.0Drug discovery: a historical perspective. J DrewsScience200010720314No
210916221622.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
211016221622.050.950.9The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
211116211621.051.551.5Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
211216211621.031.531.5How cells read TGF-beta signals. J MassagueNat Rev Mol Cell Biol200011252892No
211348621620.7130.043.3Management of hepatocellular carcinoma. Jordi Bruix, Morris Sherman, Hepatology200516250051No
2114162021620.2415.341.5Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M MacKay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
211516201620.035.135.1On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
211616201620.060.160.1The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
211716201620.048.848.8Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
211816201620.082.182.1Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
211932391619.585.842.9Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
212032371618.588.144.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
212116181618.029.629.6Altering the genome by homologous recombination. M R CapecchiScience19892660260No
212216171617.035.535.5The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
212316171617.043.643.6Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
212432331616.5105.052.5CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. Jing Huang, Alexander D MacKerellJ Comput Chem201323832629Yes
212564651616.2192.048.0Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
212616161616.065.365.3The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
212796941615.7375.462.6Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
212832311615.5109.854.9A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
212932311615.581.640.8Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
213016151615.085.485.4The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
213116151615.046.346.3Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
213216141614.068.968.9Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
213316131613.056.156.1Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
213448391613.0119.639.9Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
213548381612.793.631.2Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
213680621612.4163.832.8Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
213732241612.092.346.1Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
213816111611.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
213948321610.7129.943.3I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
214032211610.5110.255.1Nitric oxide synthases: regulation and function. Ulrich Forstermann, William C SessaEur Heart J201221890489No
214132201610.097.348.6Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
214216101610.048.048.0Glycobiology: Toward Understanding the Function of Sugars. Raymond A DwekChem Rev199611848770Yes
214348281609.3128.542.8Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
214432181609.067.934.0Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
2145209001607.7567.643.7Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
214648221607.397.432.5Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
214748221607.3166.055.3Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
214832141607.0119.859.9Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
214916071607.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
215016071607.035.535.5Far-field optical nanoscopy. Stefan W HellScience200717525330No
215132121606.064.732.4Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
215216051605.037.237.2Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
215316051605.039.639.6Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
215432081604.066.833.4Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
215532071603.5111.555.8Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
2156192381603.21342.5111.9The REDCap consortium: Building an international community of software platform partners. Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, J Biomed Inform201931078660Yes
215716031603.072.972.9The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
215832061603.069.334.6Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
215916021602.083.783.7Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P De LevaJ Biomech19968872282Yes
216032021601.080.040.0A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
216116011601.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
216248011600.3150.350.1Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S Van Der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
216316001600.032.232.2An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
216416001600.032.532.5The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
216531981599.064.032.0Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
216615991599.049.849.8The pollution of the marine environment by plastic debris: a review. Jose G B DerraikMar Pollut Bull200212405208No
216747971599.0154.351.4Mendelian randomization analysis with multiple genetic variants using summarized data. Stephen Burgess, Adam Butterworth, Simon G ThompsonGenet Epidemiol201324114802Yes
216815981598.040.940.9Tumor necrosis factor (TNF). L J OldScience19852413547Yes
216915981598.055.355.3AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
217047931597.7173.857.9Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
217147901596.7192.264.1Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
217215961596.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
217315961596.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
217415951595.051.051.0Domino Reactions in Organic Synthesis. Lutz F TietzeChem Rev199611848746Yes
217531881594.0109.554.8Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
217615931593.046.546.5Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
217715931593.039.539.5HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
217815921592.066.366.3Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217915921592.045.245.2The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
218015921592.048.148.1Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
218115911591.062.762.7Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
218215911591.037.137.1Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
218315901590.037.237.2VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
218415901590.057.357.3Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
218531781589.086.743.4Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
218615891589.049.949.9Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
218715891589.051.151.1Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
218831741587.0165.382.7Depression. Gin S Malhi, J John MannLancet201830396512No
218931731586.591.445.7Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
219031721586.0100.650.3Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
219131721586.0102.251.1The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
219215861586.036.436.4The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
219315851585.040.440.4Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
219415841584.040.640.6Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
219515841584.037.437.4The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
219615841584.037.037.0Huntington's disease. Francis O WalkerLancet200717240289No
219763341583.5126.831.7A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
219831661583.063.431.7Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
219915831583.035.935.9Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
220015821582.043.643.6Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
220115821582.029.929.9Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
220231641582.0106.653.3From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
220315811581.037.337.3Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
220415801580.059.559.5Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
220515801580.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
220615791579.054.454.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
220715781578.045.645.6Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
220831561578.084.342.1Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
220915771577.064.164.1Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
221015761576.043.843.8Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
221115761576.0107.9107.9The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
221231521576.00.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
221315761576.068.768.7Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
221415751575.065.965.9How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
221515741574.034.234.2Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
221615741574.048.348.3The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
221715731573.061.361.3Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
221847181572.7174.558.2Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
221915721572.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
222031421571.0108.554.2The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
222115701570.033.933.9Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
222215701570.033.233.2Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
222315701570.043.043.0Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
222478471569.4193.938.8Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J BartonBioinformatics200919151095Yes
222547061568.7114.638.2Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
2226109801568.6242.434.6Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
222731371568.50.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
222815681568.066.366.3Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
222915681568.040.640.6Proinflammatory cytokines. C A DinarelloChest200010936147No
223015681568.030.230.2Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
223115681568.051.251.2Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
223231361568.089.144.5Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
223347011567.0135.045.0AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. G Paxinos, C R Watson, P C EmsonJ Neurosci Methods19806110810Yes
223431341567.070.735.4Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
223515671567.062.162.1Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
223615661566.044.044.0Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
223715661566.044.644.6Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
223815661566.045.645.6A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
223915641564.047.847.8Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
224046921564.0118.839.6Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
224115641564.046.746.7Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
224231281564.0113.856.9Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
224346921564.0202.567.5Hepatocellular carcinoma. Alejandro Forner, Maria Reig, Jordi BruixLancet201829307467No
224415631563.070.870.8Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
224515631563.045.145.1Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
224631261563.0103.051.5Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BackhedNature201222972297No
224731251562.564.632.3Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
224815621562.052.852.8Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
224946841561.3177.159.0Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
225015611561.062.562.5The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
225115611561.057.357.3The non-canonical NF-κB pathway in immunity and inflammation. Shao-Cong SunNat Rev Immunol201728580957No
225231201560.076.738.4Emerging roles of caspase-3 in apoptosis. A G Porter, R U JanickeCell Death Differ199910200555No
225315601560.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
225431201560.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbruckGenetics194317247100Yes
225515591559.043.543.5An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
225615591559.048.948.9Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
225731181559.081.941.0Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
225815581558.036.736.7The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
225915581558.043.043.0Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
226015571557.044.044.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
226115571557.044.844.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
226215571557.065.765.7Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
226331101555.095.647.8CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
226431091554.563.331.6Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
226531081554.0109.254.6Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
226615531553.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
226715531553.041.241.2The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
226846591553.0102.234.1TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
226931051552.578.039.0Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
227031051552.5100.050.0DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
227146561552.0104.434.8Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
227215521552.033.833.8The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
227331031551.584.142.0An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
227415511551.053.553.5Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
227515511551.038.238.2Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
227631011550.5173.486.7Sarcopenia. Alfonso J Cruz-Jentoft, Avan A SayerLancet201931171417No
227715501550.051.651.6Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
227815491549.059.259.2Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
227915491549.044.644.6Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
228030971548.574.037.0How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
228146451548.3110.136.7Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
228215481548.046.846.8Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
228346431547.798.632.9The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
228415461546.064.564.5The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A De MortonAust J Physiother200919463084Yes
228515451545.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
228630891544.5102.951.5New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
228715441544.044.944.9Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
228815441544.039.839.8R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
228915441544.047.847.8The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
229015441544.063.163.1Diagnostic and Statistical Manual of Mental Disorders (DSM). Dolores Elaine BattleCodas201324413388Yes
229146311543.7130.043.3A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
229230861543.098.449.2Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
229315421542.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F RosenblattPsychol Rev195813602029Yes
229430821541.066.033.0The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
229515411541.029.229.2CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
229630791539.5130.065.0Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
229715391539.030.730.7E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
229815391539.047.747.7Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
229915391539.059.259.2Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
230030771538.50.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
230115381538.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
230215381538.030.730.7The significance of responses of the genome to challenge. B McClintockScience198415739260No
2303245981537.4702.643.9New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
230415371537.027.627.6Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
230515371537.043.943.9The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
230646051535.099.933.3Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
230715351535.044.744.7The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
230830701535.097.848.9Liquid phase condensation in cell physiology and disease. Yongdae Shin, Clifford P BrangwynneScience201728935776No
230976711534.2318.563.7DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
231015341534.045.645.6Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
231115341534.034.734.7Molecular themes in oncogenesis. J M BishopCell19911988146No
231215341534.042.742.7Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
231315341534.047.747.7Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
231415341534.052.652.6Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
231515341534.066.966.9The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
231615341534.043.843.8The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
231715341534.060.360.3The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
231830681534.073.436.7Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
231961351533.8141.735.4Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
232015331533.058.958.9The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
232115331533.027.227.2The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
232215321532.059.159.1Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
232315321532.057.157.1Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
232430641532.070.135.0Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
232515321532.035.135.1Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
232645951531.7131.243.7Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
232730631531.598.149.0Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
232845911530.30.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
232930601530.077.638.8Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
233015301530.038.238.2What is a support vector machine? William S NobleNat Biotechnol200617160063No
233115291529.041.641.6Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
233215281528.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
233315281528.055.155.1Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
233415281528.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
233515281528.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
233630561528.077.338.6Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
233715281528.039.139.1TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
233830551527.562.031.0Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
233930551527.5115.357.6MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Martin Steinegger, Johannes SodingNat Biotechnol201729035372Yes
234015271527.040.840.8Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
234115271527.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
234215271527.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
234315271527.063.163.1Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
234415261526.044.644.6Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
234515251525.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
234615251525.065.265.2Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Daniel J DruckerCell Metab201829617641No
234730491524.578.739.4Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
234891451524.2336.256.0Second-generation PLINK: rising to the challenge of larger and richer datasets. Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J LeeGigascience201525722852Yes
234915231523.040.340.3Early signals in the mitogenic response. E RozengurtScience19863018928No
235030461523.091.745.9Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
235176141522.8246.049.2CD-HIT: accelerated for clustering the next-generation sequencing data. Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong LiBioinformatics201223060610Yes
235215221522.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
235315221522.045.845.8Function and information content of DNA methylation. Dirk SchubelerNature201525592537No
235415211521.059.159.1How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
235515201520.051.151.1Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
235676001520.0306.761.3Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
235730401520.092.846.4Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
235815201520.038.338.3Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
235915201520.049.849.8The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
236030371518.5133.366.7New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Anushka Dongre, Robert A WeinbergNat Rev Mol Cell Biol201930459476No
236115181518.039.239.2Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
236230361518.098.049.0Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluisio J D Barros, Vania N HirakataBMC Med Res Methodol200314567763Yes
236315181518.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
236415171517.050.650.6The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
236515171517.051.451.4Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
236615171517.041.941.9Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
236745491516.3103.434.5Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
236815161516.039.639.6Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
236915161516.046.646.6Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
237015161516.043.043.0Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
237130291514.5342.6171.3The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Karin E De Visser, Johanna A JoyceCancer Cell202336917948No
237215141514.039.039.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
237315141514.057.557.5How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
237490841514.0285.547.6Prodigal: prokaryotic gene recognition and translation initiation site identification. Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J HauserBMC Bioinformatics201020211023Yes
237530271513.559.629.8Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
237615131513.044.344.3Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
237715131513.034.834.8Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
237815131513.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
237915131513.078.378.3Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Dimitrios TsikasAnal Biochem201727789233No
238015131513.074.874.8Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Nicholas A MeanwellJ Med Chem201829400967No
2381105881512.6684.097.7IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt Von Haeseler, Robert LanfearMol Biol Evol202032011700Yes
238215121512.041.441.4The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
238315111511.046.046.0Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DomlingChem Rev200616402771No
2384105751510.7427.061.0Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
238530211510.596.348.1The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
238615101510.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
2387151001510.0591.559.1MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul Van Der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
238830191509.5130.665.3Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
238915091509.040.240.2The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
239045241508.0106.135.4OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
239130151507.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
239215071507.036.136.1Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
239315071507.047.147.1Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
239415071507.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
239530141507.066.833.4Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
239630131506.579.239.6Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
239715061506.033.933.9Tumor suppressor genes. R A WeinbergScience19911659741No
239815061506.061.961.9Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
239915061506.036.136.1The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
240060231505.8165.941.5AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
240130111505.5121.260.6Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
240215041504.044.644.6Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
240330071503.564.232.1Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
240430071503.599.149.5bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
240515031503.039.639.6T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
240630051502.585.842.9The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
240715021502.044.944.9Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
240815011501.055.455.4Lyme disease. A C SteereN Engl J Med19892668764No
240915011501.062.662.6Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
241015011501.084.684.6A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
241115011501.036.036.0Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
241215001500.041.841.8Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
241315001500.073.673.6The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
241444971499.0106.335.4Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornoe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
241514991499.031.631.6Human natural killer cells. Michael A CaligiuriBlood200818650461No
241629981499.075.237.6The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
241729961498.077.838.9Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
241814981498.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
241914981498.041.441.4Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
242014981498.033.633.6Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
242114981498.047.247.2Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
242214971497.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
2423179621496.8505.742.1Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, J Gerontol A Biol Sci Med Sci200111253156Yes
242429931496.589.244.6Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
242529931496.572.936.5Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
242614961496.034.534.5The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
242714961496.054.054.0The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
242829911495.5101.150.5The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
242929911495.576.838.4Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
243044861495.3117.939.3LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
243114951495.045.645.6Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
243229891494.5132.666.3Principal component analysis: a review and recent developments. Ian T Jolliffe, Jorge CadimaPhilos Trans A Math Phys Eng Sci201626953178No
243314941494.034.634.6The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
243414931493.0108.8108.8The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
243514931493.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
243644791493.00.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
243714921492.034.134.1Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
243829841492.083.741.9The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
243914911491.043.543.5Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
244014911491.041.441.4Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
244114911491.098.498.4A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
244229801490.061.630.8Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
244314901490.034.334.3Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
244429801490.0111.555.8AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
244559581489.5293.773.4The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
244644681489.3126.442.1Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
244759571489.2192.048.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
244814891489.039.939.9The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
244944661488.7170.456.8Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
245014881488.044.744.7A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
245129761488.059.529.8Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
245229761488.060.730.4Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
245344641488.0125.141.7Nitric oxide and peroxynitrite in health and disease. Pal Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
2454133861487.3418.346.5The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
245529741487.081.140.5Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
245614871487.033.633.6Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
245774331486.6235.747.1Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
245814861486.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
245944571485.798.732.9Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
246029711485.576.038.0The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
246114851485.038.938.9Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
246214851485.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
246329691484.558.429.2Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
246414841484.057.457.4Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
246514841484.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
246644511483.795.531.8The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
246714831483.029.729.7Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
246814831483.036.136.1PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
246914831483.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
247014831483.071.471.4SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
247114821482.049.449.4Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
247229641482.058.529.2Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
247388911481.8235.439.2An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
247429631481.555.327.6T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
247529631481.5102.151.0Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
247614811481.042.742.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
247714811481.045.845.8Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
247859231480.8210.152.5Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
247929611480.587.843.9Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
248029601480.071.235.6The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
248114801480.034.834.8Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
248288791479.8241.440.2Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
248329591479.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
248429591479.582.241.1New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
248529591479.5101.550.8Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
248688731478.8246.741.1A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
248729571478.5113.856.9Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
248859141478.5221.255.3Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
248914781478.037.437.4A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
249044341478.0281.293.7How to perform a meta-analysis with R: a practical tutorial. Sara Balduzzi, Gerta Rucker, Guido SchwarzerEvid Based Ment Health201931563865Yes
249129551477.557.928.9STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
249214771477.033.633.6The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
249314771477.070.470.4Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
249429521476.075.237.6C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
249514761476.033.833.8Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
249629521476.0112.256.1Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
249729511475.50.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
249829501475.065.132.5LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
249929491474.573.236.6Inflammation, stress, and diabetes. Kathryn E Wellen, Gokhan S HotamisligilJ Clin Invest200515864338No
250014741474.033.333.3Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
250114741474.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
250214741474.050.150.1The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
250329461473.064.932.5A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
250414731473.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
250514731473.027.527.5The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
250614731473.029.929.9Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
250714731473.051.151.1Electrolytes and interphases in Li-ion batteries and beyond. Kang XuChem Rev201425351820Yes
250844181472.7146.348.8Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
250914721472.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
251014721472.042.042.0The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
251114721472.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
251244151471.7103.234.4Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
251358851471.2157.439.4Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
251414701470.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
251544081469.3136.145.4TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
251629371468.586.343.1Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
251744041468.0216.872.3Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
251814681468.037.237.2Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
251929361468.086.543.2Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
252014681468.043.843.8Endometriosis. Serdar E BulunN Engl J Med200919144942No
252114681468.044.544.5Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
252229351467.563.731.9The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
252329341467.093.046.5The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
252429341467.068.434.2The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
252514671467.085.585.5Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
252629331466.585.742.9Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M Van Der BliekScience201222936770No
252729311465.50.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
252814651465.064.164.1The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
252958601465.0251.262.8Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
253014651465.087.487.4Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. Janice M MorseQual Health Res201526184336Yes
253129291464.588.144.0Opportunities and challenges for a sustainable energy future. Steven Chu, Arun MajumdarNature201222895334No
253229281464.069.634.8Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
253314641464.035.935.9Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
253414641464.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
253529281464.075.737.9Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
253629271463.580.340.1The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
253729261463.0127.663.8Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
253829261463.056.728.4Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
253914631463.041.241.2Comparative physiology of salt and water stress. R MunnsPlant Cell Environ200211841667Yes
254014621462.021.021.0Central dogma of molecular biology. F CrickNature19704913914No
254114621462.044.544.5Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
254229241462.0105.652.8Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
254329221461.083.041.5Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
254414611461.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
254529221461.072.736.4Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
254614611461.069.169.1Embracing the unknown: disentangling the complexities of the soil microbiome. Noah FiererNat Rev Microbiol201728824177No
254729211460.561.030.5Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
254829211460.50.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
254914601460.034.234.2Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
255014601460.042.342.3Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
255114601460.038.438.4Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
255214601460.061.261.2Overview of the IL-1 family in innate inflammation and acquired immunity. Charles A DinarelloImmunol Rev201829247995No
255314591459.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
2554102101458.6314.544.9Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
255514581458.034.334.3Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
255614581458.043.343.3The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
255714581458.064.864.8Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
255829131456.559.929.93' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
255929131456.572.736.4Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
256014561456.078.078.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
256129111455.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
256214551455.052.852.8Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
256314551455.056.256.2Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
256414551455.027.627.6ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
256514541454.042.442.4The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
256614541454.044.944.9Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
256729081454.088.944.5Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
256814541454.036.036.0Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
256914541454.049.949.9The frailty syndrome: definition and natural history. Qian-Li XueClin Geriatr Med201121093718No
257014541454.068.368.3Body Mass Index: Obesity, BMI, and Health: A Critical Review. Frank Q NuttallNutr Today201527340299Yes
257129071453.5117.258.6Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
257229071453.573.836.9Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
257358131453.2165.341.3GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
257414531453.029.929.9Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
257529041452.0185.092.5Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
257629041452.080.440.2A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
257714521452.053.853.8Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
257829041452.088.844.4Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
257914511451.027.227.2Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
258029021451.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
258114511451.055.755.7A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
258229021451.0131.465.7Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Florian R Greten, Sergei I GrivennikovImmunity201931315034No
258372541450.8268.953.8The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
258443511450.3111.137.0Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
258529001450.082.741.4Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
258614501450.032.132.1A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
258714491449.036.836.8General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
258828981449.073.036.5Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
258928981449.077.638.8Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
259014491449.046.846.8Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
259128961448.060.530.2Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
259214481448.029.229.2Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
259343441448.0115.638.5Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C Kearon, J Thromb Haemost200515842354Yes
259414481448.045.545.5Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
259528941447.073.636.8Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
259628931446.566.433.2The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
259743391446.3104.434.8Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
259857851446.2202.850.7The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
259914461446.050.250.2Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
260014461446.022.622.6Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
260128921446.00.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
260214461446.040.040.0Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
260314461446.049.549.5Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
260428901445.0102.351.1Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
260514451445.034.634.6Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
260614451445.030.730.7Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SudhofNature200818923512No
260728891444.590.645.3Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
260814441444.042.942.9Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
260914441444.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
261014441444.032.532.5Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
261128881444.086.743.4The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
261272171443.4159.031.8Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
261314431443.038.138.1Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
261414431443.043.543.5Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
261514431443.039.539.5The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
261614421442.032.332.3HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
261728841442.00.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
261814421442.029.929.9Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
261928831441.573.736.9Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
262057661441.5160.740.2The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan Shaw, Lancet200516182882Yes
262143241441.387.529.2Exosomes: composition, biogenesis and function. Clotilde Thery, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
262214411441.049.749.7Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
262314411441.034.734.7Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
262428821441.00.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
262514411441.036.336.3The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
262643181439.391.930.6Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
262714391439.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
262828771438.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
262928771438.5135.467.7An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Jesper L R Andersson, Stamatios N SotiropoulosNeuroimage201626481672Yes
263014381438.025.925.9The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
263114381438.041.641.6Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
263214371437.034.834.8Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
263314371437.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
263443091436.3129.643.2A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
263571801436.0138.727.7Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mader, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
263614361436.038.838.8Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
263714361436.060.260.2Mediation Analysis: A Practitioner's Guide. Tyler J VanderWeeleAnnu Rev Public Health201626653405No
263828701435.094.947.5A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschopeJ Am Coll Cardiol201323684677No
263914341434.027.727.7The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
264028681434.084.542.2Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
264114341434.034.634.6Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
264243021434.096.332.1NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
264314341434.039.139.1Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
264414341434.046.546.5Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
264514341434.0177.8177.8Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. Shifu ChenImeta202338868435Yes
264643001433.3144.148.0Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
264743001433.3137.145.7Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
264828661433.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
264928651432.576.438.2Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
265014321432.026.826.8Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
265114321432.034.934.9Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
265214321432.039.139.1Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
265328621431.082.241.1Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
265414311431.026.826.8c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
265514311431.037.537.5Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
265642931431.0107.535.8Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
265714301430.034.434.4Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
265842901430.0123.941.3Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
265914301430.035.835.8The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
266028571428.5100.350.1Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
266114281428.043.643.6Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
266214281428.077.577.5Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
266342841428.090.430.1Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
266428561428.0126.963.5The role of inflammation in depression: from evolutionary imperative to modern treatment target. Andrew H Miller, Charles L RaisonNat Rev Immunol201626711676No
266528551427.595.447.7Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
266642821427.3106.635.5Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-Ichiro NoroAngew Chem Int Ed Engl200415114565Yes
266757091427.2257.264.3Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GokerBMC Bioinformatics201323432962Yes
266828531426.585.142.5Accurate and robust brain image alignment using boundary-based registration. Douglas N Greve, Bruce FischlNeuroimage200919573611Yes
266914261426.040.840.8A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
267014261426.030.730.7Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
267114261426.043.843.8The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
267214261426.040.740.7The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
267314261426.071.771.7Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
267428511425.566.833.4Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
267528501425.078.439.2Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
267614251425.058.958.9Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
267714251425.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
267814251425.031.431.4Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
267914251425.049.349.3Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamas RoszerMediators Inflamm201526089604No
268014241424.044.244.2The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
268114231423.034.434.4Optical microcavities. Kerry J VahalaNature200312917698Yes
268242681422.7110.436.8Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
268314221422.023.523.5A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
268414221422.00.00.0Comparing individual means in the analysis of variance. J W TukeyBiometrics194918151955Yes
268528431421.565.432.7Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
268628421421.0107.653.8Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
268714211421.033.933.9Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
268814211421.027.527.5Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
268914211421.034.634.6The basic science of gene therapy. R C MulliganScience19938493530No
269014211421.032.432.4Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
269114211421.048.748.7The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
269214191419.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
269314191419.039.339.3Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
269414191419.039.639.6Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
269514181418.053.753.7Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
269628361418.085.842.9Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
269714181418.023.123.1Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
269814181418.035.535.5Hydrogen sulphide and its therapeutic potential. Csaba SzaboNat Rev Drug Discov200717948022No
269914181418.039.639.6Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
270028341417.061.730.9Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
270128341417.0121.460.7Designing hydrogels for controlled drug delivery. Jianyu Li, David J MooneyNat Rev Mater201629657852Yes
270270811416.2204.640.9Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
270328321416.092.246.1Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
270428301415.074.237.1Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
270542441414.791.430.5Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
270628291414.5111.155.5Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
270714141414.050.350.3Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
270828281414.099.950.0Inflammasomes: mechanism of assembly, regulation and signalling. Petr Broz, Vishva M DixitNat Rev Immunol201627291964No
270928271413.572.736.4CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
271014131413.041.741.7How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
271114131413.034.834.8Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
271214131413.065.365.3The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
271384781413.0313.152.2ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos SimmerlingJ Chem Theory Comput201526574453Yes
271414121412.033.333.3Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
271528221411.062.831.4Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
271614111411.044.744.7Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
271714111411.050.450.4Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
271828201410.0179.689.8A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
271914101410.040.440.4Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
272028201410.095.948.0Severe sepsis and septic shock. Derek C Angus, Tom Van Der PollN Engl J Med201323984731No
272128201410.0125.562.8Activation of apoptosis signalling pathways by reactive oxygen species. Maureen Redza-Dutordoir, Diana A Averill-BatesBiochim Biophys Acta201627646922No
272214091409.036.136.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
272314091409.034.534.5Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
272456351408.8130.132.5Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
2725112681408.5503.863.0Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K ChandaNat Commun201930944313Yes
272614081408.034.034.0Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
272714081408.044.444.4Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
272814081408.028.428.4microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
272914081408.033.833.8Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
273014071407.030.830.8Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
273128141407.075.637.8miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
2732140641406.4525.552.5The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
273314061406.029.629.6Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
273428121406.062.131.1NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
273556211405.2189.347.3Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
273614051405.048.048.0The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
273798341404.9293.241.9pROC: an open-source package for R and S+ to analyze and compare ROC curves. Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus MullerBMC Bioinformatics201121414208Yes
273828091404.584.142.0The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
273984241404.0228.538.1Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat RoblesBioinformatics200516081474Yes
274014041404.044.444.4Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
274142121404.098.132.7Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
274256131403.2182.445.6Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
274328061403.071.936.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
274414031403.042.742.7Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
274570151403.0337.967.6Using the framework method for the analysis of qualitative data in multi-disciplinary health research. Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi RedwoodBMC Med Res Methodol201324047204Yes
274628051402.582.641.3Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
274728051402.568.234.1Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
274828051402.581.440.7Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
274914021402.037.837.8Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
275014011401.052.552.5The case for motivated reasoning. Z KundaPsychol Bull19902270237No
275114011401.031.431.4Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
2752154111401.0486.344.2International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
275314011401.034.834.8Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
275414011401.058.658.6The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615Yes
275528021401.0103.051.5Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde TheryCell201626967288No
275628011400.558.929.4Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
275714001400.027.027.0Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
275814001400.029.329.3Searching for intellectual turning points: progressive knowledge domain visualization. Chaomei ChenProc Natl Acad Sci U S A200414724295Yes
275927991399.50.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
276027991399.574.737.4Epidemiology of Parkinson's disease. Lonneke M L De Lau, Monique M B BretelerLancet Neurol200616713924No
276183971399.5254.642.4Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
276213991399.025.525.5Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
276327981399.063.931.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
276441951398.3155.251.7A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
276513981398.031.531.5Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
276613981398.025.025.0SUMO: a history of modification. Ronald T HayMol Cell200515808504No
276727951397.5104.952.5Tumour heterogeneity and resistance to cancer therapies. Ibiayi Dagogo-Jack, Alice T ShawNat Rev Clin Oncol201829115304No
276827941397.0103.251.6Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
276913971397.033.033.0Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
277027931396.50.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
277127931396.584.742.4Crosstalk of reactive oxygen species and NF-κB signaling. Michael J Morgan, Zheng-Gang LiuCell Res201121187859No
277213961396.050.750.7Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
277313951395.046.846.8Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
277413951395.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
277513951395.0146.4146.4Sample size determination and power analysis using the G*Power software. Hyun KangJ Educ Eval Health Prof202134325496No
277655771394.2237.659.4Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
277713941394.046.646.6Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
277827881394.0123.161.5Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Luigi Ferrucci, Elisa FabbriNat Rev Cardiol201830065258No
277941801393.3102.534.2METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Goncalo R AbecasisBioinformatics201020616382Yes
278013931393.030.330.3Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
278141781392.7137.145.7MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
278269631392.6274.254.8Frailty in elderly people. Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth RockwoodLancet201323395245No
278313921392.046.046.0Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
278413921392.083.783.7COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
278513911391.031.431.4Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
278613911391.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
278713901390.023.823.8Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
2788125101390.0320.135.6MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
278955571389.2301.175.3Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. Shaoqing Ren, Kaiming He, Ross Girshick, Jian SunIEEE Trans Pattern Anal Mach Intell201727295650Yes
279013891389.041.041.0Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
279155561389.0176.344.1Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R DeWaardProc Biol Sci200312614582Yes
279213891389.039.939.9Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
279355551388.8113.728.4Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
279427771388.557.528.8Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
279513881388.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
279627751387.584.942.5Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
279713871387.042.242.2Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
279813871387.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
279913871387.045.245.2Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
280027741387.0148.574.2Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. Amy J H Kind, William R BuckinghamN Engl J Med201829949490Yes
280127731386.581.840.9Inflammatory mechanisms in obesity. Margaret F Gregor, Gokhan S HotamisligilAnnu Rev Immunol201121219177No
280227721386.060.230.1Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
280313861386.045.945.9Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
280427711385.571.735.9A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
280527711385.567.033.5Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P Van Den Driessche, James WatmoughMath Biosci200212387915Yes
280683101385.0280.246.7The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
280741551385.0123.141.0HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
280827691384.540.320.1Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
280927691384.598.649.3A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
281027691384.5398.3199.2Sample sizes for saturation in qualitative research: A systematic review of empirical tests. Monique Hennink, Bonnie N KaiserSoc Sci Med202234785096Yes
281113841384.032.732.7The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
281227651382.587.343.6The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
281313821382.052.452.4Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
281413821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
281527631381.593.846.9Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
281627621381.062.231.1An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
281713811381.024.324.3The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
281813811381.038.738.7Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
281913811381.033.133.1Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
282027601380.00.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
282127601380.072.336.1Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WuthrichBiochem Biophys Res Commun19836307308Yes
282213801380.071.271.2Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
282313801380.025.825.8Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
282413801380.036.436.4Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
282513801380.039.239.2The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
282613801380.043.643.6The inflammatory response in myocardial injury, repair, and remodelling. Nikolaos G FrangogiannisNat Rev Cardiol201424663091No
282741391379.7181.660.5Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
282827591379.573.136.5Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
282913791379.034.234.2Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G Von HeijneJ Mol Biol19921593632Yes
283055161379.0137.534.4The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
283113791379.063.363.3Review of the psychometric evidence of the perceived stress scale. Eun-Hyun LeeAsian Nurs Res (Korean Soc Nurs Sci)201225031113Yes
283213781378.040.340.3Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
283313781378.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
283413781378.047.747.7History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
283513781378.042.042.0The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
283641331377.7140.046.7Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
283713771377.039.539.5Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
283813771377.049.149.1Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
283955071376.8130.332.6Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
2840110141376.8282.635.3A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
284141281376.0104.034.7Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Ronnback, Elisabeth HanssonNat Rev Neurosci200616371949No
284213761376.045.445.4Drug transport across the blood-brain barrier. William M PardridgeJ Cereb Blood Flow Metab201222929442No
284327511375.5144.972.5A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
284427511375.578.239.1A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
284582521375.3344.657.4Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark WymerHepatology201626707365No
284613751375.053.053.0Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
284713751375.042.542.5Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
284854991374.8129.032.2A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
284913741374.029.829.8Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
285013741374.029.229.2The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
285127471373.566.433.2Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
285227471373.560.830.4Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
285327471373.578.739.4Mitochondria: in sickness and in health. Jodi Nunnari, Anu SuomalainenCell201222424226No
285427461373.00.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
285513731373.036.536.5A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
285627461373.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
285727461373.057.928.9TM-align: a protein structure alignment algorithm based on the TM-score. Yang Zhang, Jeffrey SkolnickNucleic Acids Res200515849316Yes
285854921373.0147.436.9Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
285941191373.097.932.6Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
286027451372.554.027.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
286127451372.5100.550.2Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
286241171372.392.830.9Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
286313721372.036.836.8Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
286413711371.054.654.6Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
286513711371.038.738.7Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
286613711371.038.938.9Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
286713701370.047.847.8An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
286827401370.050.325.1Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
286913701370.031.031.0Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
287027391369.556.128.1Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
287127381369.0183.691.8Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
287241071369.0105.335.1Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
287341071369.0147.149.0Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
287427381369.077.438.7Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
287513681368.040.540.5Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
287627361368.078.839.4Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
287713671367.029.629.6Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
287840981366.0216.772.2Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
287913661366.048.248.2Interleukin-1. C A DinarelloRev Infect Dis19846369481No
288013661366.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
288127321366.0109.354.6Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Michael A Gimbrone, Guillermo Garcia-CardenaCirc Res201626892962No
288227311365.574.537.2Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
288313651365.048.748.7Multiple calcium channels and neuronal function. R J MillerScience19872432656No
288427291364.581.941.0What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
288513641364.061.661.6A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
288613641364.051.651.6The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
288754531363.2129.932.5Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
288813631363.043.143.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
288913631363.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
289013631363.043.143.1The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
289113631363.042.742.7Determining association constants from titration experiments in supramolecular chemistry. Pall ThordarsonChem Soc Rev201121125111Yes
289227241362.070.635.3A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
289327231361.558.129.1Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
289427231361.581.140.5Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
289513611361.041.241.2Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
289613611361.029.129.1The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
289713611361.027.727.7Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
289827211360.50.00.0A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H Vandendool, P D KratzJ Chromatogr196314062605Yes
289913601360.047.347.3The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
290013601360.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
290113601360.027.727.7Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
290213601360.029.629.6The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
290313591359.035.535.5Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
290413591359.026.326.3Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
290527171358.562.531.2Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
290640751358.3130.543.5Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681Yes
290713581358.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
290867881357.6197.439.5Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
290927141357.059.129.6Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
291040691356.3145.748.6Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Dmitry B Zorov, Magdalena Juhaszova, Steven J SollottPhysiol Rev201424987008No
291113561356.045.845.8Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
291227121356.072.436.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
291327121356.064.432.2A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
291440661355.30.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
291513551355.00.00.0The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
291613551355.059.559.5Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
291713551355.040.540.5The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
291813551355.037.437.4N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
291927091354.563.731.9The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
292027091354.569.334.6Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
292140631354.3149.449.8The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
292213541354.037.237.2Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
292313541354.033.333.3Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
292413541354.039.639.6Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
292527081354.0113.656.8Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
292627071353.556.228.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
292740601353.3100.133.4Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
292813531353.055.855.8Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
292913531353.032.432.4Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
293040581352.7108.636.2Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
293127051352.5112.356.1The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
293240571352.3163.354.4Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Antonio Ayala, Mario F Munoz, Sandro ArguellesOxid Med Cell Longev201424999379No
293313521352.044.244.2A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
293440551351.7107.235.7Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
293527021351.074.137.0Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
293654041351.0150.337.6Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
293713511351.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
293813501350.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
293926991349.555.027.5Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
294026991349.577.238.6Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
294126981349.058.329.1Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
294226981349.076.838.4Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
294313491349.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
294413491349.031.831.8Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
294526971348.50.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
294613481348.035.335.3Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
294713481348.056.756.7Cystic fibrosis. J Stuart ElbornLancet201627140670No
294826951347.560.230.1The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
294926951347.562.331.1Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
295013471347.030.430.4Human papillomavirus and cervical cancer. Eileen M BurdClin Microbiol Rev200312525422No
295126941347.094.647.3Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
295226941347.075.737.9Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
295313471347.044.044.0Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
295413471347.088.488.4Multicollinearity and misleading statistical results. Jong Hae KimKorean J Anesthesiol201931304696Yes
295513461346.058.858.8Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
295613461346.050.650.6Epidemiology and risk factors for IBD. Ashwin N AnanthakrishnanNat Rev Gastroenterol Hepatol201525732745No
295713461346.0106.6106.6Complex heatmap visualization. Zuguang GuImeta202238868715Yes
295826911345.586.043.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
295913451345.047.547.5Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
296026901345.064.132.0NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
296113451345.041.041.0The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
296213451345.031.331.3Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
296313451345.038.538.5Plant productivity and environment. J S BoyerScience198217808529Yes
296426891344.574.737.4Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
296513441344.062.362.3Error in medicine. L L LeapeJAMA19947503827Yes
296613441344.036.436.4Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
296713441344.033.533.5Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
296813441344.048.148.1Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjostromJ Intern Med201323163728No
296926871343.50.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
297026861343.073.136.5BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
297140291343.0148.449.5Ecological momentary assessment. Saul Shiffman, Arthur A Stone, Michael R HuffordAnnu Rev Clin Psychol200818509902No
297226861343.086.843.4The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
297313421342.036.336.3Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
297413421342.023.023.0Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
297513421342.028.528.5Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
297613421342.029.229.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
297726831341.550.325.1New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
297813411341.036.336.3The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
297913411341.035.735.7Supported membranes: scientific and practical applications. E SackmannScience19968539599No
298026821341.00.00.0Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
298126811340.562.431.2Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
298226801340.060.730.4Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
298313401340.040.740.7Depression in the elderly. George S AlexopoulosLancet200515936426No
298440191339.7117.439.1Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Gunter Oberdorster, Eva Oberdorster, Jan OberdorsterEnviron Health Perspect200516002369No
298513391339.052.552.5Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
298640171339.0121.640.5The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
298726781339.084.242.1Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
298826761338.083.241.6A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
298913381338.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
299026761338.048.324.1DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
299113381338.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
299213381338.040.940.9pegas: an R package for population genetics with an integrated-modular approach. Emmanuel ParadisBioinformatics201020080509Yes
299326761338.071.235.6Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
299426761338.0100.850.4Comparative Protein Structure Modeling Using MODELLER. Benjamin Webb, Andrej SaliCurr Protoc Bioinformatics201627322406Yes
299526751337.5101.750.9Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
299680231337.2193.032.2Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I De Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
299713371337.035.535.5Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
299813371337.040.040.0Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
299913371337.032.432.4Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
300026741337.0635.4317.7Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool. Ivica Letunic, Peer BorkNucleic Acids Res202438613393Yes
300113361336.030.930.9Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
300213361336.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
300326711335.576.338.1Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
300426711335.50.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
300526711335.586.943.5Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
300626711335.586.843.4Infernal 1.1: 100-fold faster RNA homology searches. Eric P Nawrocki, Sean R EddyBioinformatics201324008419Yes
300726701335.058.929.4Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
300826691334.565.232.6ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoit D'Autreaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
300953361334.0135.233.8Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar Von Heijne, Soren BrunakJ Mol Biol200415223320Yes
301040021334.096.232.1Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
301113341334.050.450.4Considerations in determining sample size for pilot studies. Melody A HertzogRes Nurs Health200818183564No
301266681333.6337.167.4Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
301326671333.562.631.3Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
301440001333.3149.549.8Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
301513331333.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
301639981332.7115.838.6Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
301726651332.575.237.6Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
301826651332.5114.257.1Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Douglas J Morrison, Tom PrestonGut Microbes201626963409No
301913321332.033.333.3The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
302026641332.091.245.6Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
302113321332.029.529.5VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
302213321332.038.538.5Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
302313321332.038.938.9Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
302426641332.059.229.6The Polycomb complex PRC2 and its mark in life. Raphael Margueron, Danny ReinbergNature201121248841No
302539951331.7104.834.9Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
302613311331.063.963.9New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
302713311331.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
302813311331.00.00.0Cellular resistance to infection. G B MacKanessJ Exp Med196214467923Yes
302953221330.5129.232.3Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
303013301330.052.652.6Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
303113301330.046.046.0Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
303239891329.7142.447.5PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
303326591329.5105.052.5A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
303426591329.50.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
303526591329.568.634.3Interneurons of the hippocampus. T F Freund, G BuzsakiHippocampus19968915675No
303666471329.4236.347.3Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
303739881329.3111.037.0FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Morgan N Price, Paramvir S Dehal, Adam P ArkinMol Biol Evol200919377059Yes
303826581329.0102.551.2Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
303913291329.052.552.5Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
304026571328.578.039.0Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
304113281328.038.238.2Rethinking schizophrenia. Thomas R InselNature201021068826No
304213281328.058.758.7The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
304326541327.058.429.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
304439801326.7100.433.5The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
3045132631326.3352.435.2Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, F C Marini, D S Krause, R J Deans, A Keating, D J Prockop, Em HorwitzCytotherapy200616923606Yes
304613261326.049.549.5Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
304713261326.030.030.0r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
304826511325.562.431.2Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
304926511325.570.635.3Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
305013251325.049.149.1The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
305126501325.067.333.6Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
305226491324.554.827.4ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
305313241324.088.988.9The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
305413241324.036.036.0The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
305513241324.035.235.2Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
305626481324.059.529.8Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
305726471323.576.938.5Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
305813231323.050.250.2Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
305913231323.059.659.6A decade of immune-checkpoint inhibitors in cancer therapy. Caroline RobertNat Commun202032732879Yes
306039681322.7205.668.5Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
3061105801322.5365.645.7Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S MarksAm J Prev Med19989635069Yes
306213221322.025.425.4Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
306313221322.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
306426441322.049.324.6Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
306539651321.7196.365.4In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
306613211321.027.627.6Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
306713201320.036.236.2Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
306813201320.00.00.0Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
306913201320.029.329.3Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
307013201320.00.00.0Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
307113201320.033.533.5Identifying and characterizing binding sites and assessing druggability. Thomas A HalgrenJ Chem Inf Model200919434839Yes
307213201320.037.137.1Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
307326401320.0102.151.0Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Jerome Galon, Daniela BruniNat Rev Drug Discov201930610226No
307413191319.035.935.9Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
307513191319.046.346.3Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
307626371318.50.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
307713181318.054.554.5A simple method for determination of serum catalase activity and revision of reference range. L GothClin Chim Acta19912029780Yes
307813181318.039.639.6What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
307913181318.031.331.3Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
308039521317.3111.837.3Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
308126341317.043.421.7Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
308213171317.032.932.9Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
308313171317.036.236.2The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
308413171317.060.860.8The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
308513171317.027.727.7Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
308613171317.027.127.1Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
308713171317.037.537.5Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
308826331316.582.941.5An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
308913161316.033.133.1Bee and wasp venoms. E HabermannScience19724113805No
309013161316.035.935.9The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
309113161316.041.441.4Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
309213161316.032.432.4Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
309313161316.032.332.3Papillomavirus infections--a major cause of human cancers. H Zur HausenBiochim Biophys Acta19968876633No
309426321316.068.534.2The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
309513161316.039.339.3Philosophical conceptions of the self: implications for cognitive science. Shaun GallagherTrends Cogn Sci200010637618Yes
309626321316.047.523.8Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
309713161316.033.433.4Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
309826321316.075.437.7Regulation of type I interferon responses. Lionel B Ivashkiv, Laura T DonlinNat Rev Immunol201424362405No
309926301315.052.526.2CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
310013151315.034.234.2Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
3101118271314.1304.633.8Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J Van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
310213141314.047.147.1Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
310313141314.035.335.3Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
310426281314.066.133.0Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
310526281314.094.747.4Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
310613141314.026.826.8Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
310726281314.074.737.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
310813141314.036.636.6Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
310913141314.035.035.0AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
311026271313.5123.161.5Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
311126271313.561.030.5Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
311226271313.556.128.1Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
3113144451313.2282.825.7Model-based analysis of ChIP-Seq (MACS). Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley LiuGenome Biol200818798982Yes
311413131313.066.566.5Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Hector F Escobar-MorrealeNat Rev Endocrinol201829569621No
311513121312.038.538.5Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
311613121312.039.439.4The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
311713121312.029.029.0Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
311813121312.033.433.4Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
311913121312.027.927.9The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. P StothardBiotechniques200010868275Yes
312013121312.030.030.0Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
312113121312.028.328.3The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
312213121312.049.649.6Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Georgia SalantiRes Synth Methods201226062083Yes
312326231311.573.937.0A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
312439341311.386.828.9A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
312513111311.022.922.9Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
312639331311.0103.234.4Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
312713101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
312826191309.50.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
312926181309.061.130.6Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
313026181309.054.627.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
313113091309.035.635.6Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
313226181309.064.232.1Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
313326181309.055.127.6Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
313413091309.046.346.3Human milk oligosaccharides: every baby needs a sugar mama. Lars BodeGlycobiology201222513036No
313591611308.7261.037.3Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
313613081308.035.435.4Drug delivery and targeting. R LangerNature19989579855No
313713081308.025.025.0NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
313813081308.040.640.6Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
313926151307.570.335.1Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
314013071307.062.462.4A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
314113071307.043.343.3The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
314213071307.028.928.9Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
314326141307.065.832.9Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
314413071307.047.947.9Type 2 inflammation in asthma--present in most, absent in many. John V FahyNat Rev Immunol201525534623No
314513061306.029.829.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
314613061306.042.142.1Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
314713061306.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
314813051305.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
314913051305.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
315013051305.031.531.5Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
315126081304.051.425.7Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
315213041304.026.026.0Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
315326081304.056.928.4Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
315426071303.551.325.6Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
315526061303.066.033.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
315613031303.032.932.9A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
315713031303.030.430.4S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
315813031303.052.252.2Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
315978161302.7300.150.0GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin ZhangNucleic Acids Res201728407145Yes
316026041302.080.040.0A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
316139061302.099.533.2Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
316226041302.073.536.8Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Marie Cargnello, Philippe P RouxMicrobiol Mol Biol Rev201121372320No
316339051301.799.833.3Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
316426031301.5188.394.2TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Jan P Meier-Kolthoff, Markus GokerNat Commun201931097708Yes
316526021301.050.125.1The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
316626011300.576.238.1Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
316726001300.047.223.6The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
316813001300.037.637.6A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
316913001300.045.145.1DREADDs for Neuroscientists. Bryan L RothNeuron201626889809No
317051971299.2116.529.1Interleukin-10 and the interleukin-10 receptor. K W Moore, R De Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
317125981299.064.732.4Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. In Suk Joung, Thomas E CheathamJ Phys Chem B200818593145Yes
317225971298.565.832.9Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
317338951298.399.033.0Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
317412981298.032.532.5Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
317525961298.054.927.4NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
317612981298.036.636.6Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
317725951297.5167.984.0The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
317877831297.2183.330.6Enzymatic assembly of DNA molecules up to several hundred kilobases. Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O SmithNat Methods200919363495Yes
317912971297.032.232.2Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
318025941297.0107.753.9The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Naatanen, T PictonPsychophysiology19873615753Yes
318112971297.041.141.1Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
318212961296.037.337.3Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
318312951295.037.037.0Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
318412951295.031.831.8ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
318525891294.554.227.1Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
318612941294.051.151.1The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
318712941294.020.920.9A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
318812941294.033.433.4Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
318912931293.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
319012931293.030.630.6Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
319112931293.036.336.3Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
319225851292.551.425.7Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
319312921292.024.324.3CD95's deadly mission in the immune system. P H KrammerNature200011048730No
319412921292.033.233.2Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
319512921292.042.542.5Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
319625831291.576.738.4Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
319712911291.030.430.4Viruses in the sea. Curtis A SuttleNature200516163346No
319890361290.9603.586.2TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui XiaMol Plant202032585190Yes
319938721290.7195.965.3Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Yan Zheng, Sylvia H Ley, Frank B HuNat Rev Endocrinol201829219149No
320064531290.6201.340.3Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A Da Fonseca, J KentNature200010706275Yes
320112901290.037.737.7Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Masabumi ShibuyaGenes Cancer201122866201Yes
320277351289.2180.430.1Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
320312891289.043.943.9Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
320412891289.039.839.8Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
320512891289.040.840.8Somatostatin. S ReichlinN Engl J Med19836139753No
320612891289.030.730.7Brain tumors. L M DeAngelisN Engl J Med200111150363No
320712891289.029.429.4Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
320812891289.033.933.9Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
320912891289.060.160.1The expanding regulatory mechanisms and cellular functions of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol202032366901No
321025761288.071.035.5Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
321112871287.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BoyumScand J Clin Lab Invest Suppl19684179066Yes
321225741287.0101.850.9The Human Intestinal Microbiome in Health and Disease. Susan V Lynch, Oluf PedersenN Engl J Med201627974040No
321325731286.587.643.8Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
321425731286.563.131.6Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
321525731286.50.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
321612861286.039.939.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
321712861286.033.233.2An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
321812851285.025.425.4Evolution of ageing. T B KirkwoodNature1977593350Yes
321912851285.049.249.2Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
322012851285.024.124.1Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
322125681284.048.824.4Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
322225681284.097.848.9Gut microbiota, metabolites and host immunity. Michelle G Rooks, Wendy S GarrettNat Rev Immunol201627231050No
322338511283.783.627.95-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
322451321283.0122.830.7Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
322512831283.062.762.7Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
322664151283.0221.744.3A simulation study of the number of events per variable in logistic regression analysis. P Peduzzi, J Concato, E Kemper, T R Holford, A R FeinsteinJ Clin Epidemiol19968970487Yes
322712831283.033.733.7Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
322812831283.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
322912831283.027.527.5Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
323051311282.8151.637.9Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
323125641282.055.227.6Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundstrom, K NilssonInt J Cancer1976178611Yes
323212821282.036.436.4Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
323312821282.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
323425641282.063.031.5ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
323525641282.0114.557.2Network analysis: an integrative approach to the structure of psychopathology. Denny Borsboom, Angelique O J CramerAnnu Rev Clin Psychol201323537483No
323638441281.3181.760.6The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Karen V Swanson, Meng Deng, Jenny P Y TingNat Rev Immunol201931036962No
323712811281.036.836.8A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
323812811281.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
323912811281.032.432.4Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
324012811281.036.536.5ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
324138411280.3150.650.2The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris BoshoffNature201829364287No
324212801280.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
324312801280.039.439.4The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. John DuncanTrends Cogn Sci201020171926No
324412801280.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
324551191279.8147.236.8Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Madler, Ning LiScience200616456071No
324638391279.7115.538.5SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stephane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
324738381279.3120.940.3Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
324812791279.023.323.3Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
324912791279.025.625.6A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
325025581279.057.228.6Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
325138351278.398.432.8The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
325212781278.027.827.8Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
325325551277.578.239.1The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
325412771277.021.721.7Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
325538311277.099.933.3Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
325612771277.036.636.6Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Rakesh K JainCancer Cell201425517747No
325725531276.567.934.0Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
325825521276.090.745.4A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
325925521276.055.727.9A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
326012761276.045.345.3Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
3261140311275.5365.133.2New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T Van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
326212751275.046.646.6Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
326312751275.038.938.9Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
326425501275.082.341.1The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
3265127471274.7436.443.6The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C De HaesJ Natl Cancer Inst19938433390Yes
326625471273.563.731.9Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
326725471273.583.341.6Toll-like receptor signaling pathways. Takumi Kawasaki, Taro KawaiFront Immunol201425309543No
326812731273.029.929.9Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
326925461273.092.546.2Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
327012731273.023.523.5Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
327112731273.049.549.5Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
327212731273.042.542.5Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
327338191273.0155.551.8Rheumatoid arthritis. Josef S Smolen, Daniel Aletaha, Iain B McInnesLancet201627156434No
327425451272.553.026.5Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
327525451272.564.132.0The regulation of IL-10 production by immune cells. Margarida Saraiva, Anne O'GarraNat Rev Immunol201020154735No
327625441272.073.436.7A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
327712721272.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
327889001271.4272.038.9Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
327938141271.3102.834.3Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
328012711271.021.121.1Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
328112711271.031.131.1Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
328212711271.081.181.1Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
328312711271.028.128.1An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
328412711271.042.942.9Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
328512711271.026.426.4Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
328625411270.5119.759.9Neurobiology of addiction: a neurocircuitry analysis. George F Koob, Nora D VolkowLancet Psychiatry201627475769No
328712701270.045.345.3Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
328812701270.049.449.4The angular gyrus: multiple functions and multiple subdivisions. Mohamed L SeghierNeuroscientist201322547530No
328925391269.559.129.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
329012691269.034.934.9Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
329112691269.050.550.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
329212691269.030.530.5Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" F D HaldanePhys Rev Lett198810038961Yes
329338071269.093.831.3Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernan, B BrumbackEpidemiology200010955408Yes
329412691269.039.139.1High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
329525371268.5138.069.0Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
329625371268.575.537.8Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
329725361268.076.838.4Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
329812681268.035.735.7Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
329912681268.042.242.2The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
330012681268.028.728.7How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
330112681268.043.643.6Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan S T B T EvansAnnu Rev Psychol200818154502No
330263391267.8122.224.4The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
330350701267.5233.158.3An ecological perspective on health promotion programs. K R McLeroy, D Bibeau, A Steckler, K GlanzHealth Educ Q19883068205No
330425341267.099.349.6Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
330525341267.069.434.7Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
330612671267.048.348.3Substance P. B PernowPharmacol Rev19836196797No
330712671267.082.482.4Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. Cheng-Hsien LiBehav Res Methods201626174714Yes
330812661266.063.663.6Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
330912661266.029.529.5Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
331012661266.036.036.0Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
331112661266.025.325.3Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
331237981266.0137.045.7Social relationships and mortality risk: a meta-analytic review. Julianne Holt-Lunstad, Timothy B Smith, J Bradley LaytonPLoS Med201020668659No
331312661266.050.750.7Vitamin D metabolism, mechanism of action, and clinical applications. Daniel D BikleChem Biol201424529992No
331463301266.0260.252.0MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah LamBioinformatics201525609793Yes
331512661266.045.245.2T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. Shane CrottyImmunity201931117010No
331625311265.580.440.2Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
331712651265.048.748.7Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
331812651265.045.345.3The mental health continuum: from languishing to flourishing in life. Corey L M KeyesJ Health Soc Behav200212096700Yes
331912651265.035.035.0MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
332012651265.030.030.0Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Andrey A ShabalinBioinformatics201222492648Yes
332163251265.0297.559.5VSEARCH: a versatile open source tool for metagenomics. Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic MahePeerJ201627781170Yes
332225291264.565.933.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
332363211264.2257.651.5KEGG: new perspectives on genomes, pathways, diseases and drugs. Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae MorishimaNucleic Acids Res201727899662Yes
332412641264.030.630.6Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
332512641264.028.228.2The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
332625281264.0105.953.0The Tumor Microenvironment Innately Modulates Cancer Progression. Dominique C Hinshaw, Lalita A ShevdeCancer Res201931350295No
332725271263.565.132.5Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
332825271263.5105.953.0Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. T J Cole, T LobsteinPediatr Obes201222715120Yes
332925271263.5127.463.7Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Laura M Doyle, Michael Zhuo WangCells201931311206No
333012631263.039.339.3MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
333112631263.026.626.6Searching for genetic determinants in the new millennium. N J RischNature200010866211No
333212621262.022.622.6NFAT proteins: key regulators of T-cell development and function. Fernando MacIanNat Rev Immunol200515928679No
333312621262.032.432.4Overview of the immune response. David D ChaplinJ Allergy Clin Immunol201020176265No
333425231261.560.230.1The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
333512611261.025.625.6Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
333612611261.037.937.9Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. J C MorrisInt Psychogeriatr19979447441Yes
333712611261.040.440.4Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
333812611261.028.628.6Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
333937821260.7175.558.5Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
334025211260.565.332.6Interaction revisited: the difference between two estimates. Douglas G Altman, J Martin BlandBMJ200312543843No
334112601260.064.464.4The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
334212601260.034.934.9Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
334312601260.024.024.0Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
334412601260.033.433.4Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
334512601260.035.135.1Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
334612601260.034.734.7The quantum internet. H J KimbleNature200818563153Yes
334712601260.031.131.1Ab-initio simulations of materials using VASP: Density-functional theory and beyond. Jurgen HafnerJ Comput Chem200818623101Yes
334825191259.590.745.4ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Tauno Metsalu, Jaak ViloNucleic Acids Res201525969447Yes
334925181259.093.746.9The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
335025181259.072.536.2Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
335112591259.035.535.5Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
335212591259.032.832.8Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
335312591259.032.232.2Optogenetics. Karl DeisserothNat Methods201121191368Yes
335412591259.057.857.8Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
335525181259.097.448.7OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. David M Emms, Steven KellyGenome Biol201526243257Yes
335625171258.568.734.4Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
335737751258.3140.947.0Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Michael A Postow, Robert Sidlow, Matthew D HellmannN Engl J Med201829320654No
335825161258.0143.371.7The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
335912581258.020.720.7The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
336012581258.065.065.0Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
336112581258.049.849.8Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
336212581258.026.426.4Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
336312581258.033.533.5Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. R ZahorecBratisl Lek Listy200111723675Yes
336412581258.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
336512581258.028.628.6Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
336612581258.037.737.7Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
336712581258.048.348.3What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
336862901258.0233.346.7Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
336912581258.048.648.6Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. Walter S LealAnnu Rev Entomol201323020622No
337025161258.085.742.9The gut microbiota--masters of host development and physiology. Felix Sommer, Fredrik BackhedNat Rev Microbiol201323435359No
337125151257.568.034.0Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
337225151257.552.126.1Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
337337721257.377.525.8SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
337412571257.026.326.3SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
337512571257.042.342.3The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
337625131256.585.142.5Superoxide dismutases: I. Occurrence in higher plants. C N Giannopolitis, S K RiesPlant Physiol197716659839Yes
337737691256.3191.263.7Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Mojtaba Vaismoradi, Hannele Turunen, Terese BondasNurs Health Sci201323480423No
337825121256.049.524.8Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
337912561256.032.932.9Apoptosis. J J CohenImmunol Today19938466628No
338012551255.022.322.3Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
338112551255.040.740.7Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
338212551255.039.139.1Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
338325081254.060.030.0DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
338425071253.575.437.7Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
338525051252.586.343.1Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
338612521252.032.032.0Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsakiNeuroscience19892687720No
338737551251.7149.349.8Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
338837551251.7123.741.2Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Irith Wiegand, Kai Hilpert, Robert E W HancockNat Protoc200818274517Yes
338937551251.7129.243.1Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
339025021251.098.349.1Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
339125021251.0100.550.2Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
339212511251.066.466.4Cisplatin: The first metal based anticancer drug. Sumit GhoshBioorg Chem201931003078No
339337511250.385.428.5Population structure and eigenanalysis. Nick Patterson, Alkes L Price, David ReichPLoS Genet200617194218Yes
339425001250.071.936.0Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
339512501250.040.640.6Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
339612501250.050.450.4Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. Peter J BarnesJ Allergy Clin Immunol201627373322No
339724991249.565.732.9Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
339824991249.577.238.6Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
339962461249.2227.645.5Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
340012491249.076.176.1The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
340112491249.022.422.4Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
340212491249.048.548.5Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). F BerenbaumOsteoarthritis Cartilage201323194896No
340324971248.555.927.9Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
3404137341248.5473.443.0A global reference for human genetic variation. , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R AbecasisNature201526432245Yes
340512481248.035.835.8Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
340637441248.0111.837.3A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
340712481248.033.233.2Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
340824951247.578.339.1Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
340912471247.020.920.9Antigen receptor tail clue. M RethNature19892927501Yes
341012471247.036.536.5The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
341112471247.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
341212471247.034.334.3Neural stimulation and recording electrodes. Stuart F CoganAnnu Rev Biomed Eng200818429704No
341312471247.047.347.3Autonomic nervous system activity in emotion: a review. Sylvia D KreibigBiol Psychol201020371374No
341412471247.035.435.4Cyclin-dependent kinases. Marcos MalumbresGenome Biol201425180339No
341524941247.0190.695.3Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
341674761246.0145.124.2Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
341712461246.047.847.8The pain self-efficacy questionnaire: Taking pain into account. Michael K NicholasEur J Pain200716446108Yes
341812461246.048.348.3A polarizing question: do M1 and M2 microglia exist? Richard M RansohoffNat Neurosci201627459405No
341912461246.0244.8244.8ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns. Malik SallamHealthcare (Basel)202336981544No
342024911245.563.631.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
342124901245.0111.956.0Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
342212451245.028.228.2Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
342312451245.034.034.0Inflammation 2010: new adventures of an old flame. Ruslan MedzhitovCell201020303867No
342412451245.066.566.5Resin composite--state of the art. Jack L FerracaneDent Mater201121093034No
342512451245.039.639.6The Danish Cancer Registry. Marianne Lundkjaer GjerstorffScand J Public Health201121775350Yes
342624891244.556.028.0Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
342712441244.038.338.3Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
342849751243.8136.434.1Gene ontology analysis for RNA-seq: accounting for selection bias. Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia OshlackGenome Biol201020132535Yes
342924871243.554.827.4Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
343024871243.552.726.4The mammalian unfolded protein response. Martin Schroder, Randal J KaufmanAnnu Rev Biochem200515952902No
343124871243.567.533.8Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
343212431243.025.425.4Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
343312431243.051.751.7Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Laura J JulianArthritis Care Res (Hoboken)201122588767No
343437281242.7138.946.3The weirdest people in the world? Joseph Henrich, Steven J Heine, Ara NorenzayanBehav Brain Sci201020550733Yes
343512421242.060.060.0Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
343612421242.024.524.5Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
343712421242.035.835.8Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532Yes
343812421242.024.624.6Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
343924831241.556.528.2Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
344012411241.063.363.3Osseointegration and its experimental background. P I BranemarkJ Prosthet Dent19836352924No
344112411241.045.045.0Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
344224821241.071.936.0Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
344312411241.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
344412411241.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
344512401240.029.029.0The columnar organization of the neocortex. V B MountcastleBrain19979153131No
344612401240.029.929.9Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
344724801240.00.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
344837201240.087.629.2Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
344961981239.6200.240.0Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
345024781239.056.628.3Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
345112391239.037.437.4Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
345224781239.073.436.7Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
345312391239.040.440.4Chronic stress, drug use, and vulnerability to addiction. Rajita SinhaAnn N Y Acad Sci200818991954No
345424781239.093.446.7Ferroptosis: Death by Lipid Peroxidation. Wan Seok Yang, Brent R StockwellTrends Cell Biol201626653790No
345537171239.0129.943.3The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Stefka Tyanova, Tikira Temu, Juergen CoxNat Protoc201627809316Yes
345661951239.0316.263.2UFBoot2: Improving the Ultrafast Bootstrap Approximation. Diep Thi Hoang, Olga Chernomor, Arndt Von Haeseler, Bui Quang Minh, Le Sy VinhMol Biol Evol201829077904Yes
345712381238.042.542.5How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
345812381238.054.854.8Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
345924751237.539.919.9A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
346049491237.2136.234.0Mussel-inspired surface chemistry for multifunctional coatings. Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B MessersmithScience200717947576Yes
346112371237.037.737.7Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
346212371237.035.935.9Cellular and molecular mechanisms of renal fibrosis. Youhua LiuNat Rev Nephrol201122009250No
346324741237.076.338.1Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
346424731236.575.137.5Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
346537091236.3102.134.0Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
346624721236.0100.950.5A real-time QRS detection algorithm. J Pan, W J TompkinsIEEE Trans Biomed Eng19853997178Yes
346712361236.026.926.9Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
346812361236.032.732.7Seed Germination and Dormancy. J D BewleyPlant Cell199712237375Yes
346912361236.034.434.4Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
347037071235.7117.639.2Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
347137061235.3134.144.7IL-6 in inflammation, immunity, and disease. Toshio Tanaka, Masashi Narazaki, Tadamitsu KishimotoCold Spring Harb Perspect Biol201425190079No
347212351235.029.029.0Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
347312351235.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
347412351235.039.139.1On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
347537051235.0110.136.7Macrophage biology in development, homeostasis and disease. Thomas A Wynn, Ajay Chawla, Jeffrey W PollardNature201323619691No
347637041234.7109.436.5AMPK: a nutrient and energy sensor that maintains energy homeostasis. D Grahame Hardie, Fiona A Ross, Simon A HawleyNat Rev Mol Cell Biol201222436748No
347712341234.067.567.5A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
347812341234.0123.3123.3The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
347924681234.058.729.4Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
348012341234.025.425.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
348124681234.049.624.8Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
348212341234.036.436.4The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
348312321232.026.026.0Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
348412321232.027.327.3Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
348512321232.027.127.1Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
348649281232.0207.151.8From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik BackhedCell201627259147No
348724631231.563.131.6Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
348824631231.5100.450.2Shared decision making--pinnacle of patient-centered care. Michael J Barry, Susan Edgman-LevitanN Engl J Med201222375967Yes
348924631231.579.239.6Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
349024631231.5182.691.3Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Fangda Leng, Paul EdisonNat Rev Neurol202133318676No
349124621231.0107.853.9Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
349212311231.060.960.9ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
349312311231.039.639.6Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
349424621231.053.726.9The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
349524621231.062.331.1Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Sophia Y Lunt, Matthew G Vander HeidenAnnu Rev Cell Dev Biol201121985671No
349612311231.041.941.9The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Peter C AustinStat Med201424122911Yes
349749231230.8141.735.4Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
3498196931230.8767.648.0SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A PevznerJ Comput Biol201222506599Yes
349924601230.076.038.0Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
350012301230.024.724.7STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
350112301230.039.139.1On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
350224601230.056.228.1microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
350312301230.033.733.7Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
350424601230.066.833.4The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Maria M Mihaylova, Reuben J ShawNat Cell Biol201121892142No
350524581229.089.844.9The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
350612291229.035.335.3Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
350773741229.0197.432.9Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, Lancet200212493255Yes
350824581229.0107.153.5Epidemiology of adult fractures: A review. Charles M Court-Brown, Ben CaesarInjury200616814787No
350912291229.027.527.5Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
351012291229.034.134.1Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
351112291229.044.144.1Microbial life in the phyllosphere. Julia A VorholtNat Rev Microbiol201223154261No
351224571228.553.526.8Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
351312281228.027.627.6The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
351412281228.038.738.7Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
351512281228.036.736.7Normal bone anatomy and physiology. Bart ClarkeClin J Am Soc Nephrol200818988698No
351612281228.037.937.9Graves' ophthalmopathy. Rebecca S BahnN Engl J Med201020181974No
351712271227.025.925.9Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
351836791226.3113.938.0Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
351912261226.035.035.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
352024511225.547.523.8Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
352124511225.572.236.1Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
352236761225.3203.667.9Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
352336761225.376.125.4Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Juri Rappsilber, Matthias Mann, Yasushi IshihamaNat Protoc200717703201Yes
352412251225.029.529.5Growth factors and cancer. S A AaronsonScience19911659742No
352512251225.079.979.9Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
352612251225.028.228.2Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
352712251225.032.332.3The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
352812251225.032.532.5Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
352961241224.8184.937.0Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G AltmanPLoS Biol201020613859No
353024491224.546.723.4The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
3531122421224.2290.829.1Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus SchultenJ Comput Chem200516222654Yes
353212241224.026.826.8Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
353312241224.022.422.4Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
353412241224.024.024.0Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
353524471223.5110.855.4Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
353624471223.554.427.2Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
353724471223.562.631.3Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
353836701223.3197.465.8ShinyGO: a graphical gene-set enrichment tool for animals and plants. Steven Xijin Ge, Dongmin Jung, Runan YaoBioinformatics202031882993Yes
353912231223.042.642.6The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
354012231223.034.434.4What is synergy? M C BerenbaumPharmacol Rev19892692037No
354112231223.027.627.6Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
354212231223.034.434.4Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
354312231223.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
354412231223.039.839.8Staphylococcus epidermidis--the 'accidental' pathogen. Michael OttoNat Rev Microbiol200919609257No
354536691223.0123.941.3The Danish National Patient Register. Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka ReboljScand J Public Health201121775347Yes
3546146761223.0455.838.0Ferroptosis: an iron-dependent form of nonapoptotic cell death. Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang, Barclay Morrison, Brent R StockwellCell201222632970Yes
354724451222.573.636.8Genome-wide efficient mixed-model analysis for association studies. Xiang Zhou, Matthew StephensNat Genet201222706312Yes
354812221222.031.931.9Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
354912221222.021.321.3Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
355024441222.063.331.6Cancer epigenetics: from mechanism to therapy. Mark A Dawson, Tony KouzaridesCell201222770212No
355112221222.054.354.3How Many Subjects Does It Take To Do A Regression Analysis. S B GreenMultivariate Behav Res199126776715Yes
355224431221.558.129.1Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794Yes
355336641221.378.426.1Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
355412211221.037.537.5The mysteries of lipoprotein(a). G UtermannScience19892530631No
355512211221.034.234.2The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
355636631221.062.520.8A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, Rene Bernards, Reuven AgamiScience200211910072Yes
355712211221.028.628.6What is principal component analysis? Markus RingnerNat Biotechnol200818327243Yes
355824411220.581.840.9Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
355912201220.040.640.6Epidemiology of heart failure. Veronique L RogerCirc Res201323989710No
356036591219.795.431.8Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
356124391219.545.522.8Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
356212191219.040.740.7Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
356324371218.543.321.6A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
356424371218.583.341.6Glycosylation in cancer: mechanisms and clinical implications. Salome S Pinho, Celso A ReisNat Rev Cancer201526289314No
356524361218.072.936.5Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
356612181218.046.246.2View through a window may influence recovery from surgery. R S UlrichScience19846143402Yes
356748721218.0129.732.4Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
356824361218.00.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
356912181218.028.828.8Pathogenesis of atherosclerosis. Erling FalkJ Am Coll Cardiol200616631513Yes
357012181218.045.245.2Constructive and unconstructive repetitive thought. Edward R WatkinsPsychol Bull200818298268No
357124361218.072.936.5Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
357212181218.036.136.1Targeting the DNA Damage Response in Cancer. Mark J O'ConnorMol Cell201526590714No
357312171217.030.330.3Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
357412171217.032.832.8Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
357512171217.00.00.0A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
357612171217.028.328.3Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
357712171217.037.537.5Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BunzliChem Rev201020151630No
357824331216.564.632.3Molecular mechanisms of T cell co-stimulation and co-inhibition. Lieping Chen, Dallas B FliesNat Rev Immunol201323470321No
357936491216.3100.633.5Fluorine in pharmaceuticals: looking beyond intuition. Klaus Muller, Christoph Faeh, Francois DiederichScience200717901324No
358012161216.052.952.9A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
358112161216.049.849.8Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
358212161216.034.634.6Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
358312161216.049.149.1Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
358412161216.034.434.4Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
358512161216.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
358612161216.040.440.4Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
358712161216.032.732.7Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
358824321216.0126.263.1The neuropathological diagnosis of Alzheimer's disease. Michael A DeTure, Dennis W DicksonMol Neurodegener201931375134No
358924321216.0122.661.3Cytokine Storm. David C Fajgenbaum, Carl H JuneN Engl J Med202033264547No
359072941215.7164.727.4Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
359124301215.058.229.1Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
359212151215.042.842.8On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
359324291214.552.826.4Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
359424291214.555.527.8Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
359524291214.569.034.5Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
359612141214.027.827.8The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
359736421214.0104.634.9A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
359812141214.030.430.4Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
359912141214.025.425.4Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
360012141214.026.526.5Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
360112141214.047.947.9Epithelial Mesenchymal Transition in Tumor Metastasis. Vivek MittalAnnu Rev Pathol201829414248No
360224261213.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
360324261213.067.733.9Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
360412131213.055.055.0Development of the practice environment scale of the Nursing Work Index. Eileen T LakeRes Nurs Health200212015780Yes
360512131213.028.928.9Sjögren's syndrome. Robert I FoxLancet200516039337No
360624261213.0135.267.6miRDB: an online database for prediction of functional microRNA targets. Yuhao Chen, Xiaowei WangNucleic Acids Res202031504780Yes
360736381212.779.126.4Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
360824251212.598.449.2Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Marta Kutas, Kara D FedermeierAnnu Rev Psychol201120809790No
360948501212.5223.856.0Random effects structure for confirmatory hypothesis testing: Keep it maximal. Dale J Barr, Roger Levy, Christoph Scheepers, Harry J TilyJ Mem Lang201324403724Yes
361012121212.052.152.1Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
361112121212.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
361212121212.030.030.0Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
361312121212.040.840.8The broaden-and-build theory of positive emotions. Barbara L FredricksonPhilos Trans R Soc Lond B Biol Sci200415347528No
361412121212.031.631.6Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
361512121212.034.634.6A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
361672701211.7264.844.1The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
361712111211.040.940.9Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
361812111211.023.823.8VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
361924221211.071.735.9The diversity and biogeography of soil bacterial communities. Noah Fierer, Robert B JacksonProc Natl Acad Sci U S A200616407148Yes
362012101210.031.031.0Area deprivation and widening inequalities in US mortality, 1969-1998. Gopal K SinghAm J Public Health200312835199Yes
362112101210.032.932.9Gibberellin metabolism and its regulation. Shinjiro YamaguchiAnnu Rev Plant Biol200818173378No
362236291209.70.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
362324181209.048.824.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
362412091209.037.537.5The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
362548351208.8192.448.1The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. L B Krupp, N G LaRocca, J Muir-Nash, A D SteinbergArch Neurol19892803071Yes
362612081208.053.353.3Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
362712081208.062.262.2The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
362812081208.039.839.8Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
362912081208.043.743.7beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
363024161208.065.532.8Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
363112081208.027.527.5The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
363212081208.020.220.2Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
363312081208.036.236.2Conceptual synthesis in community ecology. Mark VellendQ Rev Biol201020565040No
363436231207.7111.137.0Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
363524141207.085.342.6Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
363612071207.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
363712071207.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
363812071207.029.129.1Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
363912071207.056.056.0Root canal irrigants. Matthias ZehnderJ Endod200616631834No
364024141207.052.126.1Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
364124141207.062.831.4Monocyte recruitment during infection and inflammation. Chao Shi, Eric G PamerNat Rev Immunol201121984070No
364224121206.069.434.7Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
364312061206.037.437.4Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
364412061206.039.539.5Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
364512061206.027.227.2G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
364612061206.029.429.4Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
364724111205.575.337.6Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
364824111205.550.825.4Fcgamma receptors as regulators of immune responses. Falk Nimmerjahn, Jeffrey V RavetchNat Rev Immunol200818064051No
364960261205.2148.329.7Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
365012051205.027.027.0Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
365112051205.030.330.3Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
365212051205.022.122.1Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
365324091204.565.832.9Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
365424081204.048.924.4Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
365512041204.045.145.1Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
365612041204.028.728.7Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
365784271203.9170.824.4Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
365824071203.558.329.1Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
365924071203.555.327.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
366048131203.2107.026.8Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
366112031203.025.325.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
366224061203.063.031.5The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
366312031203.023.623.6Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
366412031203.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
366512021202.038.338.3Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
366612021202.030.730.7Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
366712021202.022.022.0Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
366824041202.059.729.9Efficient behavior of small-world networks. V Latora, M MarchioriPhys Rev Lett200111690461Yes
366924031201.565.432.7The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Laetitia Prut, Catherine BelzungEur J Pharmacol200312600700No
367012011201.040.240.2The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
367112011201.056.156.1Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
367212011201.033.133.1Descending pathways in motor control. Roger N LemonAnnu Rev Neurosci200818558853No
367312011201.049.949.9Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Hannah R SnyderPsychol Bull201322642228No
3674108051200.6362.040.2A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
367524001200.054.927.4Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H Von HippelJ Mol Biol19744416620Yes
367612001200.035.435.4Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
367712001200.039.539.5Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
367824001200.054.427.2Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
367912001200.037.437.4The enteric nervous system and neurogastroenterology. John B FurnessNat Rev Gastroenterol Hepatol201222392290No
368012001200.031.431.4The complex world of WNT receptor signalling. Christof NiehrsNat Rev Mol Cell Biol201223151663No
368124001200.090.945.5The blood-brain barrier. Richard Daneman, Alexandre PratCold Spring Harb Perspect Biol201525561720No
368211991199.034.934.9Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
368311991199.023.523.5IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
368411991199.041.141.1Recommended effect size statistics for repeated measures designs. Roger BakemanBehav Res Methods200516405133Yes
368523981199.063.331.6Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
368611991199.043.143.1Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. Gyorgy BuzsakiHippocampus201526135716No
368711981198.039.839.8An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
368811981198.042.042.0Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
368911981198.034.434.4Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
369011981198.054.754.7Psychedelics. David E NicholsPharmacol Rev201626841800No
369123951197.5167.683.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
369223951197.562.131.1An improved general amino acid replacement matrix. Si Quang Le, Olivier GascuelMol Biol Evol200818367465Yes
369323951197.589.344.6Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Louise C Hawkley, John T CacioppoAnn Behav Med201020652462No
369447891197.2117.829.4Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
369511971197.029.029.0Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
369611971197.031.931.9Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
369723941197.089.144.5The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
369811971197.038.338.3Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
369935911197.076.625.5Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
370023941197.092.446.2Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
370111971197.026.826.8Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
370211971197.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
370311971197.035.035.0Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Barry HalliwellPlant Physiol200616760481Yes
370423941197.086.243.1Required sample size to detect the mediated effect. Matthew S Fritz, David P MacKinnonPsychol Sci200717444920Yes
370511971197.026.726.7The action potential in mammalian central neurons. Bruce P BeanNat Rev Neurosci200717514198No
370635901196.785.328.4STATs in cancer inflammation and immunity: a leading role for STAT3. Hua Yu, Drew Pardoll, Richard JoveNat Rev Cancer200919851315No
370711961196.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
370811951195.041.041.0Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
370911951195.035.235.2Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
371023891194.555.927.9Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
371111941194.055.755.7Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
371223881194.098.249.1Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
371311941194.046.946.9Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
371411941194.041.241.2The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. R CharonJAMA200111597295Yes
371511941194.028.028.0Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
371623881194.064.132.0Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
371723881194.054.727.4Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
371811941194.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
371947741193.595.823.9Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
372011931193.054.054.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
372111931193.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
372211931193.054.854.8Reference methods for the assessment of physical characteristics of meat. K O HonikelMeat Sci199822060626Yes
372335781192.7116.638.9xCell: digitally portraying the tissue cellular heterogeneity landscape. Dvir Aran, Zicheng Hu, Atul J ButteGenome Biol201729141660Yes
372411921192.019.619.6Evolution and tinkering. F JacobScience1977860134Yes
372535751191.782.327.4Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
372623831191.560.230.1Using RepeatMasker to identify repetitive elements in genomic sequences. Maja Tarailo-Graovac, Nansheng ChenCurr Protoc Bioinformatics200919274634Yes
372735741191.3144.548.2Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
372811911191.00.00.0Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
372911911191.022.522.5The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
373011901190.029.329.3The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
373123791189.568.934.5Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
373223791189.559.829.9Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkBioinformatics200717050570Yes
373323791189.562.731.4Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NunezNat Rev Immunol201021088683No
373411891189.037.837.8Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
373523781189.051.625.8Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Javier A Menendez, Ruth LupuNat Rev Cancer200717882277No
373611891189.027.127.1The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
373711891189.039.339.3Biomedical photoacoustic imaging. Paul BeardInterface Focus201122866233Yes
373823771188.553.526.8Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
3739166351188.2371.126.5Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
374011881188.023.823.8Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
374111881188.044.544.5Surface-enhanced Raman spectroscopy: concepts and chemical applications. Sebastian SchluckerAngew Chem Int Ed Engl201424711218Yes
374211881188.078.678.6Antimicrobial Resistance: Implications and Costs. Porooshat DadgostarInfect Drug Resist201931908502No
374359391187.8200.840.2Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
374447491187.2206.751.7Development of recommendations for SEMG sensors and sensor placement procedures. H J Hermens, B Freriks, C Disselhorst-Klug, G RauJ Electromyogr Kinesiol200011018445Yes
374511871187.038.038.0Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
374623741187.063.331.6The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
374711871187.034.434.4Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
374811871187.025.525.5Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
374923741187.054.827.4Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Sharon R Browning, Brian L BrowningAm J Hum Genet200717924348Yes
375011871187.025.325.3Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
375111871187.036.836.8The social brain in adolescence. Sarah-Jayne BlakemoreNat Rev Neurosci200818354399No
375223731186.572.336.1Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
375335591186.373.124.4Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
375411861186.060.960.9Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
375511861186.052.852.8Fibromyalgia: a clinical review. Daniel J ClauwJAMA201424737367No
375659291185.8124.524.9Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
375735571185.7202.767.6Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O Da Rocha, Jailson B De AndradeSci Rep201930626917Yes
375835561185.393.131.0Pathogenic Escherichia coli. James B Kaper, James P Nataro, Harry L MobleyNat Rev Microbiol200415040260No
375923701185.0110.255.1Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
376011851185.040.740.7Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
376111851185.041.441.4Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
376211851185.030.330.3Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
376311851185.037.737.7Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. A E BlackInt J Obes Relat Metab Disord200011033980Yes
376411851185.032.132.1Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
376511851185.037.237.2Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
376611851185.046.046.0Fiber and prebiotics: mechanisms and health benefits. Joanne SlavinNutrients201323609775No
3767213201184.4535.629.8PHENIX: a comprehensive Python-based system for macromolecular structure solution. Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H ZwartActa Crystallogr D Biol Crystallogr201020124702Yes
376823681184.092.146.0Positive psychology. An introduction. M E Seligman, M CsikszentmihalyiAm Psychol200011392865Yes
376947351183.8109.727.4Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled ClaytonCurr Protoc Cell Biol200618228490Yes
377023671183.552.326.1Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
377123671183.550.925.4Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
377211831183.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
377335491183.090.530.2In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Chun-Chi Liang, Ann Y Park, Jun-Lin GuanNat Protoc200717406593Yes
377423651182.560.830.4The neural basis of decision making. Joshua I Gold, Michael N ShadlenAnnu Rev Neurosci200717600525No
377523651182.5100.850.4The social determinants of health: it's time to consider the causes of the causes. Paula Braveman, Laura GottliebPublic Health Rep201424385661No
377611821182.033.633.6Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
377711821182.027.027.0Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
377811821182.00.00.0A new microscopic principle. D GaborNature194818860291Yes
377923641182.088.344.1NAFLD: a multisystem disease. Christopher D Byrne, Giovanni TargherJ Hepatol201525920090No
378023631181.563.831.9The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
378111811181.031.331.3Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
378211811181.030.930.9The role of acetylcholine in learning and memory. Michael E HasselmoCurr Opin Neurobiol200617011181No
378323611180.577.338.6Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Lance W Peterson, David ArtisNat Rev Immunol201424566914No
378411801180.027.327.3Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
378570801180.0192.032.0The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
378611801180.043.543.5Mental illness and/or mental health? Investigating axioms of the complete state model of health. Corey L M KeyesJ Consult Clin Psychol200515982151Yes
378711801180.040.440.4Supramolecular binding thermodynamics by dispersion-corrected density functional theory. Stefan GrimmeChemistry201222782805Yes
378823591179.545.822.9Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
378923581179.044.422.2AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
379011791179.030.830.8Soil carbon sequestration impacts on global climate change and food security. R LalScience200415192216Yes
379111791179.048.648.6Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Philip C CalderBiochim Biophys Acta201525149823No
379211781178.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
379311781178.035.435.4Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
379423561178.075.037.5Extended-spectrum beta-lactamases: a clinical update. David L Paterson, Robert A BonomoClin Microbiol Rev200516223952No
379511781178.026.326.3Pyramidal neurons: dendritic structure and synaptic integration. Nelson SprustonNat Rev Neurosci200818270515No
379611781178.049.849.8The epidemiology and impact of pain in osteoarthritis. T NeogiOsteoarthritis Cartilage201323973124Yes
379758881177.6219.143.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Open Med200921603045Yes
379811771177.038.338.3Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
379911771177.032.332.3Electrogenerated chemiluminescence and its biorelated applications. Wujian MiaoChem Rev200818505298No
380047071176.8147.536.9Causal analysis approaches in Ingenuity Pathway Analysis. Andreas Kramer, Jeff Green, Jack Pollard, Stuart TugendreichBioinformatics201424336805Yes
380147051176.2122.730.7C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
380211761176.025.125.1Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
380311761176.026.626.6Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
380423521176.071.335.6Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
380523521176.056.228.1A note on quantifying follow-up in studies of failure time. M Schemper, T L SmithControl Clin Trials19968889347Yes
380611761176.023.423.4The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
380711761176.035.635.6A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
380811761176.037.437.4Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
380958791175.8163.632.7A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo PandolfiCell201121802130Yes
381023511175.571.435.7Neural regulation of endocrine and autonomic stress responses. Yvonne M Ulrich-Lai, James P HermanNat Rev Neurosci200919469025No
381123501175.0104.152.0The aggression questionnaire. A H Buss, M PerryJ Pers Soc Psychol19921403624Yes
381211751175.026.626.6Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
381346991174.8131.732.9A role for mitochondria in NLRP3 inflammasome activation. Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg TschoppNature201121124315Yes
381423491174.553.226.6Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
381570461174.3216.736.1Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
381670451174.2197.132.9Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
381711741174.046.146.1Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
381811741174.046.246.2Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
381911741174.052.852.8Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
382011741174.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
382135221174.0110.836.9DNA methylation and its basic function. Lisa D Moore, Thuc Le, Guoping FanNeuropsychopharmacology201322781841No
382235191173.0109.136.4Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
382311731173.021.621.6DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
382411731173.044.844.8Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Murray B IsmanAnnu Rev Entomol200616332203No
382511731173.045.745.7Cancer-related fatigue--mechanisms, risk factors, and treatments. Julienne E BowerNat Rev Clin Oncol201425113839No
382623461173.088.744.4Mechanisms of hepatic stellate cell activation. Takuma Tsuchida, Scott L FriedmanNat Rev Gastroenterol Hepatol201728487545No
382735181172.7154.151.4Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. Neil M Davies, Michael V Holmes, George Davey SmithBMJ201830002074Yes
382823451172.590.445.2Perceived discrimination and health: a meta-analytic review. Elizabeth A Pascoe, Laura Smart RichmanPsychol Bull200919586161Yes
382911721172.048.648.6Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
383011721172.028.628.6Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
383111721172.026.626.6Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
383211721172.00.00.0The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. C D MurrayProc Natl Acad Sci U S A192616576980Yes
383311721172.033.033.0Voltage-gated calcium channels. William A CatterallCold Spring Harb Perspect Biol201121746798No
383423431171.583.741.9Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudasN Engl J Med19921307234Yes
383511711171.043.643.6Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
383611711171.045.045.0A measure of anxiety symptoms among children. S H SpenceBehav Res Ther19989648330Yes
383711711171.022.222.2The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
383811711171.025.425.4The mitochondrial genome: structure, transcription, translation and replication. J W TaanmanBiochim Biophys Acta199910076021No
383923421171.068.534.2Collagen structure and stability. Matthew D Shoulders, Ronald T RainesAnnu Rev Biochem200919344236No
384011701170.035.835.8Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
384111701170.041.841.8Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
384211701170.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
384323391169.548.724.4Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
384435081169.3101.934.0Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
384523381169.091.545.8Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
384611691169.030.530.5Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
384723381169.050.025.0GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. Sean Davis, Paul S MeltzerBioinformatics200717496320Yes
384811691169.036.436.4Outer membrane permeability and antibiotic resistance. Anne H DelcourBiochim Biophys Acta200919100346No
384923371168.571.936.0Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. R J Ginsberg, L V RubinsteinAnn Thorac Surg19957677489Yes
385011681168.029.929.9Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
385123361168.062.531.2Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
385246721168.0131.332.8voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Charity W Law, Yunshun Chen, Wei Shi, Gordon K SmythGenome Biol201424485249Yes
385323361168.0103.651.8Biological Functions of Autophagy Genes: A Disease Perspective. Beth Levine, Guido KroemerCell201930633901No
385446711167.8124.331.1Wound repair and regeneration. Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T LongakerNature200818480812No
385535021167.30.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Vinuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
385611671167.043.143.1Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
385711671167.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
385823331166.50.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
385923331166.564.132.0Cu-catalyzed azide-alkyne cycloaddition. Morten Meldal, Christian Wenzel TornoeChem Rev200818698735No
386011661166.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
386111661166.00.00.0The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
386211661166.035.935.9Leishmaniasis. B L HerwaldtLancet199910513726No
386311661166.046.146.1Subjective well-being. The science of happiness and a proposal for a national index. E DienerAm Psychol200011392863Yes
386411661166.020.620.65-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Judith K ChristmanOncogene200212154409No
386523311165.574.737.4Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
386623311165.545.922.9NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
386711651165.027.627.6Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
386823301165.051.525.8Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
386911651165.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
387023301165.058.829.4The NF-kappaB family of transcription factors and its regulation. Andrea Oeckinghaus, Sankar GhoshCold Spring Harb Perspect Biol200920066092No
387111641164.047.847.8A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
387211641164.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
387323271163.554.927.4Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
387423271163.563.431.7A general purpose model for the condensed phases of water: TIP4P/2005. J L F Abascal, C VegaJ Chem Phys200516392929Yes
387523261163.064.132.0Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
387611631163.025.825.8Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
387723261163.051.925.9An energy budget for signaling in the grey matter of the brain. D Attwell, S B LaughlinJ Cereb Blood Flow Metab200111598490No
387811631163.031.531.5Omega-3 fatty acids in inflammation and autoimmune diseases. Artemis P SimopoulosJ Am Coll Nutr200212480795No
387923261163.075.037.5Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
388023251162.577.838.9Shaping functional architecture by oscillatory alpha activity: gating by inhibition. Ole Jensen, Ali MazaheriFront Hum Neurosci201021119777Yes
388134871162.375.125.0A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
388223241162.052.826.4Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
388311621162.022.522.5Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
388411621162.034.334.3Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
388511621162.034.834.8Innate immunity of fish (overview). Bergljot MagnadottirFish Shellfish Immunol200615950491No
388611611161.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
388711611161.032.032.0Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
388811611161.022.022.0Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
388946441161.0124.531.1REVIGO summarizes and visualizes long lists of gene ontology terms. Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav SmucPLoS One201121789182Yes
389081261160.9144.520.6The human genome browser at UCSC. W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David HausslerGenome Res200212045153Yes
389134821160.796.432.1Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
389223201160.074.237.1Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
389311601160.028.328.3BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
389411601160.033.833.8Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
389511601160.026.026.0Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
389611601160.040.740.7The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. James A ImlayNat Rev Microbiol201323712352No
389711601160.031.231.2Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
389823191159.574.637.3Stool form scale as a useful guide to intestinal transit time. S J Lewis, K W HeatonScand J Gastroenterol19979299672Yes
389923191159.50.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
390023191159.571.335.6ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
390111591159.060.160.1Mitochondrial Dynamics and Its Involvement in Disease. David C ChanAnnu Rev Pathol202031585519No
390211581158.032.732.7Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
390323161158.044.222.1Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
390411581158.028.628.6NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Weihai YingAntioxid Redox Signal200818020963No
390523151157.556.028.0Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
390623151157.571.435.7Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
390711571157.033.833.8Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
390811571157.017.317.3Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. J J HopfieldProc Natl Acad Sci U S A19744530290Yes
390911571157.00.00.0Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
391011571157.025.125.1Alpha-synuclein and neurodegenerative diseases. M GoedertNat Rev Neurosci200111433374No
391123141157.0104.152.0Introduction to the human gut microbiota. Elizabeth Thursby, Nathalie JugeBiochem J201728512250No
391223131156.571.035.5Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
391334681156.083.427.8High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
391411561156.025.325.3Stem cells in the central nervous system. R McKayScience19979082987No
391511561156.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
391611561156.052.052.0Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review. Franziska ReissSoc Sci Med201323746605Yes
391723111155.593.046.5Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
3918103961155.1336.537.4Robust enumeration of cell subsets from tissue expression profiles. Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A AlizadehNat Methods201525822800Yes
391911551155.028.628.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
392011551155.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
392111551155.023.923.9Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
392211551155.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
392311551155.029.029.0Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
392411551155.024.424.4Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
392511551155.029.829.8Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Richard M CawthonNucleic Acids Res200919129229Yes
392623101155.078.939.5Microbial interactions: from networks to models. Karoline Faust, Jeroen RaesNat Rev Microbiol201222796884No
392746191154.80.00.0The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
392811541154.00.00.0The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. G HardinScience19685699198Yes
392911541154.036.036.0Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
393011541154.030.330.3Hybridization as an invasion of the genome. James MalletTrends Ecol Evol200516701374Yes
393111541154.027.427.4Mucins in cancer: function, prognosis and therapy. Donald W KufeNat Rev Cancer200919935676No
393246151153.8148.737.2The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
393357681153.6206.341.3A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
393423071153.547.823.9A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
393523071153.580.240.1Fundamentals of cancer metabolism. Ralph J DeBerardinis, Navdeep S ChandelSci Adv201627386546No
393634601153.3103.734.6Foreign body reaction to biomaterials. James M Anderson, Analiz Rodriguez, David T ChangSemin Immunol200818162407No
393711531153.094.994.9Fibula free flap: a new method of mandible reconstruction. D A HidalgoPlast Reconstr Surg19892734406Yes
393811531153.045.945.9An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. F G HappeJ Autism Dev Disord19948040158Yes
393923061153.063.031.5Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
394011531153.038.138.1Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
394111531153.021.521.5The development of neural stem cells. S TempleNature200111689956No
394211531153.028.628.6Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WurthnerChem Commun (Camb)200415263926Yes
394323061153.092.446.2Mechanism and medical implications of mammalian autophagy. Ivan Dikic, Zvulun ElazarNat Rev Mol Cell Biol201829618831No
394423051152.545.722.9Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
394523051152.592.346.1Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
394623051152.559.729.9The oxytocin receptor system: structure, function, and regulation. G Gimpl, F FahrenholzPhysiol Rev200111274341No
394769151152.5226.837.8Open Babel: An open chemical toolbox. Noel M O'Boyle, Michael Banck, Craig A James, Chris Morley, Tim Vandermeersch, Geoffrey R HutchisonJ Cheminform201121982300Yes
394823041152.064.032.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
394911521152.031.331.3The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
395011511151.060.860.8The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
395111511151.035.435.4Cytochrome p450 and chemical toxicology. F Peter GuengerichChem Res Toxicol200818052394No
395223011150.5112.456.2Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Justin M Long, David M HoltzmanCell201931564456No
395311501150.026.526.5Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
395411501150.032.432.4DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
395534501150.070.023.3Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
395611501150.050.350.3The theory of planned behaviour: reactions and reflections. Icek AjzenPsychol Health201121929476No
395711501150.045.345.3A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
395834491149.786.628.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
395934491149.779.526.5Mitochondria, oxidants, and aging. Robert S Balaban, Shino Nemoto, Toren FinkelCell200515734681No
396022981149.047.823.9Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
396111491149.00.00.0Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
396211491149.034.834.8Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
396311491149.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
396411491149.028.228.2Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
396545951148.891.522.9DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
3966114881148.8438.843.9The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherPLoS Med200919621070No
396722971148.563.331.6DNA methylation: roles in mammalian development. Zachary D Smith, Alexander MeissnerNat Rev Genet201323400093No
396811481148.021.321.3Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
396911481148.044.344.3Perceptual selectivity for color and form. J TheeuwesPercept Psychophys19921620571No
397034441148.095.831.9Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
397111481148.026.226.2Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
397211481148.027.327.3Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
397322961148.060.530.2Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. L Pellerin, P J MagistrettiProc Natl Acad Sci U S A19947938003Yes
397411481148.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
397522951147.50.00.0Modified reagents for determination of urea and ammonia. A L Chaney, E P MarbachClin Chem196213878063Yes
397668851147.5616.8102.8ColabFold: making protein folding accessible to all. Milot Mirdita, Konstantin Schutze, Yoshitaka Moriwaki, Lim Heo, Sergey Ovchinnikov, Martin SteineggerNat Methods202235637307Yes
397711471147.029.329.3The emotional brain, fear, and the amygdala. Joseph LeDouxCell Mol Neurobiol200314514027No
397868801146.7164.027.3Alpha-synuclein in Lewy bodies. M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M GoedertNature19979278044Yes
397934391146.3137.145.7Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. Edon Vitaku, David T Smith, Jon T NjardarsonJ Med Chem201425255204No
398011461146.035.235.2Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
398122921146.0104.252.1Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
398211461146.039.739.7The Delphi technique: myths and realities. Catherine PowellJ Adv Nurs200312581103No
398311461146.027.527.5The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
398411461146.031.831.8Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Jill E ClarridgeClin Microbiol Rev200415489351No
398522911145.577.838.9Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M De LorgerilLancet19921351198Yes
398622911145.563.131.6Adjusting for multiple testing--when and how? R Bender, S LangeJ Clin Epidemiol200111297884No
398711451145.044.344.3Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
398811451145.025.625.6Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
398922901145.095.447.7The structure of psychological well-being revisited. C D Ryff, C L KeyesJ Pers Soc Psychol19957473027Yes
399022901145.066.433.2The cerebellar cognitive affective syndrome. J D Schmahmann, J C ShermanBrain19989577385Yes
399111451145.00.00.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
399222901145.00.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
399311451145.033.533.5Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
399411451145.038.738.7Targeting metastasis. Patricia S SteegNat Rev Cancer201627009393No
399511451145.059.059.0Why is depression more common among women than among men? Christine KuehnerLancet Psychiatry201727856392No
399622891144.563.831.9Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. D Rice, S BaroneEnviron Health Perspect200010852851No
399722891144.558.729.4Inflammatory bowel disease. Clara Abraham, Judy H ChoN Engl J Med200919923578No
399845781144.5148.737.2Biomolecular condensates: organizers of cellular biochemistry. Salman F Banani, Hyun O Lee, Anthony A Hyman, Michael K RosenNat Rev Mol Cell Biol201728225081No
399945771144.2117.629.4Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G Von HeijneProtein Eng19979051728Yes
400011441144.029.429.4Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
400111441144.028.528.5Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
400245751143.8165.641.4A basic introduction to fixed-effect and random-effects models for meta-analysis. Michael Borenstein, Larry V Hedges, Julian P T Higgins, Hannah R RothsteinRes Synth Methods201026061376Yes
400322871143.574.337.1A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
400422861143.065.232.6Flexible regression models with cubic splines. S Durrleman, R SimonStat Med19892657958Yes
400511431143.031.131.1An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
400611431143.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DeeseJ Exp Psychol195913664879Yes
400711431143.022.722.7The evolutionary significance of cis-regulatory mutations. Gregory A WrayNat Rev Genet200717304246No
400811431143.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
400957141142.8323.264.6Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7. Andrew Rambaut, Alexei J Drummond, Dong Xie, Guy Baele, Marc A SuchardSyst Biol201829718447Yes
401034281142.787.729.2Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
401122851142.564.432.2The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Alicia A Walf, Cheryl A FryeNat Protoc200717406592Yes
401211421142.015.615.6Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
401322841142.052.126.1InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
401411421142.024.924.9The muscular dystrophies. Alan E H EmeryLancet200211879882No
401511421142.022.922.9Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
401622831141.596.148.0Global estimates of visual impairment: 2010. Donatella Pascolini, Silvio Paolo MariottiBr J Ophthalmol201222133988Yes
401711411141.020.020.0Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
401811411141.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
401911411141.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
402011411141.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
402111411141.036.236.2Molecular pathogenesis and mechanisms of thyroid cancer. Mingzhao XingNat Rev Cancer201323429735No
402211411141.039.139.1Measures of Diagnostic Accuracy: Basic Definitions. Ana-Maria SimundicEJIFCC200927683318Yes
402322811140.562.231.1Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassagueJ Biol Chem19863456347Yes
402445621140.5108.727.2SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
402511401140.034.434.4Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
402611401140.025.125.1Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
402711401140.040.640.6Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
402811401140.029.929.9Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
402911401140.039.439.4Spontaneous dissection of the carotid and vertebral arteries. W I SchievinkN Engl J Med200111259724No
403011401140.024.824.8Large-scale recording of neuronal ensembles. Gyorgy BuzsakiNat Neurosci200415114356No
403122801140.056.428.2CpG islands and the regulation of transcription. Aimee M Deaton, Adrian BirdGenes Dev201121576262No
403211391139.026.626.6New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
403311391139.022.122.1Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
403411391139.034.834.8α-Synuclein in Parkinson's disease. Leonidas StefanisCold Spring Harb Perspect Med201222355802No
403522771138.567.033.5How should meta-regression analyses be undertaken and interpreted? Simon G Thompson, Julian P T HigginsStat Med200212111920Yes
403622771138.572.236.1Exploring the brain network: a review on resting-state fMRI functional connectivity. Martijn P Van Den Heuvel, Hilleke E Hulshoff PolEur Neuropsychopharmacol201020471808No
403722771138.575.537.8The economy of brain network organization. Ed Bullmore, Olaf SpornsNat Rev Neurosci201222498897No
403811381138.022.522.5Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
403922761138.068.834.4Systematic optimization of long-range corrected hybrid density functionals. Jeng-Da Chai, Martin Head-GordonJ Chem Phys200818315032Yes
404022751137.542.521.2T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
404122751137.553.426.7How to interpret LC3 immunoblotting. Noboru Mizushima, Tamotsu YoshimoriAutophagy200717611390No
404211371137.036.236.2Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
404311371137.037.237.2Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
404422731136.574.337.1Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
404534091136.3142.247.4A new method for detecting anaerobic threshold by gas exchange. W L Beaver, K Wasserman, B J WhippJ Appl Physiol (1985)19863087938Yes
404634091136.3115.838.6A new rating scale for Alzheimer's disease. W G Rosen, R C Mohs, K L DavisAm J Psychiatry19846496779Yes
404734091136.3230.977.0Estimating psychological networks and their accuracy: A tutorial paper. Sacha Epskamp, Denny Borsboom, Eiko I FriedBehav Res Methods201828342071Yes
404811361136.036.536.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
404922721136.046.923.4A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
405011361136.037.137.1Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
405111361136.031.331.3Biological effects of resveratrol. L FremontLife Sci200010680575No
405211361136.035.035.0Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
405311361136.023.523.5Unfolding the role of protein misfolding in neurodegenerative diseases. Claudio SotoNat Rev Neurosci200312511861No
405411361136.023.423.4Automated NMR structure calculation with CYANA. Peter GuntertMethods Mol Biol200415318003Yes
405511361136.031.631.6Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Paul H YanceyJ Exp Biol200516043587No
405622721136.093.646.8Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. Joseph A Durlak, Emily P DuPreAm J Community Psychol200818322790No
405711361136.030.330.3Forests and climate change: forcings, feedbacks, and the climate benefits of forests. Gordon B BonanScience200818556546No
405811361136.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
405922721136.055.627.8Clonal evolution in cancer. Mel Greaves, Carlo C MaleyNature201222258609No
406022721136.071.235.6The human microbiome: at the interface of health and disease. Ilseung Cho, Martin J BlaserNat Rev Genet201222411464No
406134071135.7130.043.3Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
406211351135.036.236.2Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
406311351135.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes
406411351135.025.325.3The molecular biology of coronaviruses. Paul S MastersAdv Virus Res200616877062No
406511351135.025.225.2Evolution of the neocortex: a perspective from developmental biology. Pasko RakicNat Rev Neurosci200919763105No
406645391134.8135.733.9PACKMOL: a package for building initial configurations for molecular dynamics simulations. L Martinez, R Andrade, E G Birgin, J M MartinezJ Comput Chem200919229944Yes
406722691134.578.539.2Plant polyphenols as dietary antioxidants in human health and disease. Kanti Bhooshan Pandey, Syed Ibrahim RizviOxid Med Cell Longev200920716914No
406811341134.055.055.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
406911341134.043.843.8Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
407011341134.036.236.2Image matching as a diffusion process: an analogy with Maxwell's demons. J P ThirionMed Image Anal19989873902Yes
407111341134.040.340.3Chemistry and biochemistry of dietary polyphenols. Rong TsaoNutrients201022254006No
407222671133.553.826.9Mechanisms of endocytosis. Gary J Doherty, Harvey T McMahonAnnu Rev Biochem200919317650No
407334001133.390.930.3Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
407411331133.00.00.0Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
407511331133.021.521.5Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
4076113301133.0446.944.7Comprehensive Integration of Single-Cell Data. Tim Stuart, Andrew Butler, Paul Hoffman, Christoph Hafemeister, Efthymia Papalexi, William M Mauck, Yuhan Hao, Marlon Stoeckius, Peter Smibert, Rahul SatijaCell201931178118Yes
407722651132.550.125.1Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. P J Roberts, C J DerOncogene200717496923No
407822651132.559.229.6Recent developments in the MAFFT multiple sequence alignment program. Kazutaka Katoh, Hiroyuki TohBrief Bioinform200818372315Yes
407911321132.024.324.3Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
408011321132.021.921.9Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
408111321132.032.032.0Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
408222641132.047.123.6RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
408311321132.024.524.5Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
408411321132.025.325.3The self-tuning neuron: synaptic scaling of excitatory synapses. Gina G TurrigianoCell200818984155No
408533961132.0164.454.8miRBase: from microRNA sequences to function. Ana Kozomara, Maria Birgaoanu, Sam Griffiths-JonesNucleic Acids Res201930423142Yes
408622631131.573.036.5PARP inhibitors: Synthetic lethality in the clinic. Christopher J Lord, Alan AshworthScience201728302823No
408711311131.051.651.6Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
408811311131.040.640.6Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
408911311131.040.140.1On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
409011311131.026.926.9A cortical-hippocampal system for declarative memory. H EichenbaumNat Rev Neurosci200011252767No
409111311131.038.438.4Vitamin D status: measurement, interpretation, and clinical application. Michael F HolickAnn Epidemiol200918329892No
4092113101131.0464.946.5QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Penny F Whiting, Anne W S Rutjes, Marie E Westwood, Susan Mallett, Jonathan J Deeks, Johannes B Reitsma, Mariska M G Leeflang, Jonathan A C Sterne, Patrick M M Bossuyt, Ann Intern Med201122007046Yes
409322611130.597.748.9Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. N L Glass, G C DonaldsonAppl Environ Microbiol19957747954Yes
409422611130.552.126.1p21 in cancer: intricate networks and multiple activities. Tarek Abbas, Anindya DuttaNat Rev Cancer200919440234No
409511301130.062.262.2The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
409611301130.020.520.5The evolutionary advantage of recombination. J FelsensteinGenetics19744448362Yes
409711301130.027.827.8Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
409811301130.040.340.3Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
409911301130.019.319.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
410011291129.029.329.3Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
410111291129.031.331.3Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
410211291129.036.836.8Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
410311291129.025.625.6Complement. Second of two parts. M J WalportN Engl J Med200111297706No
410411291129.032.132.1Distance-based tests for homogeneity of multivariate dispersions. Marti J AndersonBiometrics200616542252Yes
410511291129.037.437.4Designing cell-compatible hydrogels for biomedical applications. Dror SeliktarScience201222654050No
410622571128.50.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
410711281128.051.851.8The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
410811281128.029.029.0The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
410911281128.027.127.1Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
411011281128.028.528.5P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
411111281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
411211281128.029.929.9Sleep-dependent memory consolidation. Robert StickgoldNature200516251952No
411322561128.0106.853.4The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Yuanyuan Zhang, Zemin ZhangCell Mol Immunol202032612154No
411422551127.558.629.3Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie Beral, Lancet200312927427Yes
411511271127.056.856.8Psychophysical scaling with applications in physical work and the perception of exertion. G BorgScand J Work Environ Health19902345867Yes
411611271127.023.023.0Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
411711271127.057.357.3The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Ergul Belge KurutasNutr J201627456681No
411822541127.097.949.0EMT Transition States during Tumor Progression and Metastasis. Ievgenia Pastushenko, Cedric BlanpainTrends Cell Biol201930594349No
411922531126.566.633.3The spread of obesity in a large social network over 32 years. Nicholas A Christakis, James H FowlerN Engl J Med200717652652Yes
412011261126.036.936.9The central autonomic network: functional organization, dysfunction, and perspective. E E BenarrochMayo Clin Proc19938412366No
412111261126.031.131.1The developmental origins of adult disease. D J P BarkerJ Am Coll Nutr200415640511No
412222521126.063.331.6Frailty in relation to the accumulation of deficits. Kenneth Rockwood, Arnold MitnitskiJ Gerontol A Biol Sci Med Sci200717634318No
412311261126.029.729.7Trypan blue exclusion test of cell viability. W StroberCurr Protoc Immunol200118432654Yes
412422521126.067.533.8Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
412511261126.052.652.6Dietary fiber and prebiotics and the gastrointestinal microbiota. Hannah D HolscherGut Microbes201728165863No
412622511125.50.00.0Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
412722511125.576.638.3The Li-ion rechargeable battery: a perspective. John B Goodenough, Kyu-Sung ParkJ Am Chem Soc201323294028Yes
412833761125.3119.139.7The triple aim: care, health, and cost. Donald M Berwick, Thomas W Nolan, John WhittingtonHealth Aff (Millwood)200818474969Yes
412922501125.066.033.0A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
413022501125.055.427.7The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
413122501125.0114.257.1Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
413211251125.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
413322501125.083.641.8Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available. Miguel A Hernan, James M RobinsAm J Epidemiol201626994063Yes
413444991124.8156.439.1Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
413522491124.562.631.3Reactive oxygen species in cancer. Geou-Yarh Liou, Peter StorzFree Radic Res201020370557No
413644971124.2358.189.5AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings. Jerome Eberhardt, Diogo Santos-Martins, Andreas F Tillack, Stefano ForliJ Chem Inf Model202134278794Yes
413711241124.034.134.1Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
413822481124.050.325.1Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
413911241124.022.222.2Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
414011241124.042.042.0Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. D R LivingstoneMar Pollut Bull200111525283No
414144961124.0134.233.5Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
414222471123.557.528.8ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences. Dean Laslett, Bjorn CanbackNucleic Acids Res200414704338Yes
414311231123.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
414411231123.037.337.3Behavior rating inventory of executive function. Ida Sue BaronChild Neuropsychol200011419452Yes
414511231123.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
414611231123.033.833.8Lanthanide-based luminescent hybrid materials. Koen BinnemansChem Rev200919650663Yes
414722461123.069.935.0Fiber types in mammalian skeletal muscles. Stefano Schiaffino, Carlo ReggianiPhysiol Rev201122013216No
414833681122.7102.934.3Immune checkpoint blockade: a common denominator approach to cancer therapy. Suzanne L Topalian, Charles G Drake, Drew M PardollCancer Cell201525858804No
414922451122.50.00.0Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
415044901122.5122.530.6An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
415122451122.582.241.1Coronaviruses: an overview of their replication and pathogenesis. Anthony R Fehr, Stanley PerlmanMethods Mol Biol201525720466No
415211221122.035.035.0Comparing evolvability and variability of quantitative traits. D HouleGenetics19921732160Yes
415311221122.040.740.7Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
415411221122.035.935.9Investigating neighborhood and area effects on health. A V Diez RouxAm J Public Health200111684601No
415511221122.027.527.5The primate basal ganglia: parallel and integrative networks. Suzanne N HaberJ Chem Neuroanat200314729134No
415611221122.046.746.7Making sense of the meaning literature: an integrative review of meaning making and its effects on adjustment to stressful life events. Crystal L ParkPsychol Bull201020192563No
415711221122.037.837.8The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Donald C McMillanCancer Treat Rev201322995477No
415822431121.546.223.1MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Wei Zhang, Hui Tu LiuCell Res200211942415No
415922431121.554.527.2Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. Turk Rhen, John A CidlowskiN Engl J Med200516236742No
416044851121.2120.830.2A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
416144851121.2152.438.1Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
416211211121.049.449.4Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
416311211121.038.638.6Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
416411211121.023.923.9ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
416511211121.021.521.5Cytokines in cancer pathogenesis and cancer therapy. Glenn DranoffNat Rev Cancer200414708024No
416633631121.089.329.8Stress and the brain: from adaptation to disease. E Ron De Kloet, Marian Joels, Florian HolsboerNat Rev Neurosci200515891777No
416711211121.022.122.1mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
416822421121.061.630.8Delivering nanomedicine to solid tumors. Rakesh K Jain, Triantafyllos StylianopoulosNat Rev Clin Oncol201020838415No
416944821120.5111.928.0Permutation tests for joinpoint regression with applications to cancer rates. H J Kim, M P Fay, E J Feuer, D N MidthuneStat Med200010649300Yes
417022411120.551.225.6Glycosylation in cellular mechanisms of health and disease. Kazuaki Ohtsubo, Jamey D MarthCell200616959566No
4171145641120.3435.333.5The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , JAMA200312748199No
417256011120.2154.230.810-year follow-up of intensive glucose control in type 2 diabetes. Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W NeilN Engl J Med200818784090Yes
417311201120.029.829.8Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
417411201120.024.924.9Cells of origin in cancer. Jane E VisvaderNature201121248838No
417544781119.5113.728.4The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
417611191119.040.640.6A theory of visual attention. C BundesenPsychol Rev19902247540Yes
417711191119.030.330.3The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
417811191119.023.323.3mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
417911191119.031.731.7The underappreciated role of muscle in health and disease. Robert R WolfeAm J Clin Nutr200616960159No
418011191119.030.630.6Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Satoshi IkemotoBrain Res Rev200717574681No
418111191119.031.631.6Neuronal circuitry for pain processing in the dorsal horn. Andrew J ToddNat Rev Neurosci201021068766No
418211181118.085.485.4Fundamental patterns of knowing in nursing. B CarperANS Adv Nurs Sci1978110216Yes
418311181118.032.632.6Allostasis and allostatic load: implications for neuropsychopharmacology. B S McEwenNeuropsychopharmacology200010649824No
418455901118.0171.934.4Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Gregory Y H Lip, Robby Nieuwlaat, Ron Pisters, Deirdre A Lane, Harry J G M CrijnsChest201019762550Yes
418511181118.057.757.7COVID-19: immunopathology and its implications for therapy. Xuetao CaoNat Rev Immunol202032273594Yes
418633531117.770.323.4X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Robert L Camp, Marisa Dolled-Filhart, David L RimmClin Cancer Res200415534099Yes
418733531117.775.625.2FIMO: scanning for occurrences of a given motif. Charles E Grant, Timothy L Bailey, William Stafford NobleBioinformatics201121330290Yes
418844701117.5179.044.8Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
418922351117.50.00.0Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McClellandNature196414248725Yes
419022341117.094.847.4Emotional processing of fear: exposure to corrective information. E B Foa, M J KozakPsychol Bull19862871574Yes
419111171117.027.627.6Marine viruses and their biogeochemical and ecological effects. J A FuhrmanNature199910376593No
419211171117.033.933.9On the relationship between emotion and cognition. Luiz PessoaNat Rev Neurosci200818209732No
419333501116.798.532.8Electrical energy storage for the grid: a battery of choices. Bruce Dunn, Haresh Kamath, Jean-Marie TarasconScience201122096188Yes
419422331116.580.940.5Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
419533491116.3101.533.8Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. Charlotte Soneson, Michael I Love, Mark D RobinsonF1000Res201526925227Yes
419678141116.3674.296.3The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James RubinLancet202032112714No
419711161116.034.134.1The phylogenetic regression. A GrafenPhilos Trans R Soc Lond B Biol Sci19892575770Yes
419811161116.00.00.0Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
419922321116.048.424.2The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
420011161116.00.00.0Some informational aspects of visual perception. F AttneavePsychol Rev195413167245Yes
420111161116.038.438.4A novel automated method to measure total antioxidant response against potent free radical reactions. Ozcan ErelClin Biochem200414725941Yes
420211161116.026.226.2Immunosuppressive drugs for kidney transplantation. Philip F HalloranN Engl J Med200415616206No
420311161116.019.319.3The concept of synthetic lethality in the context of anticancer therapy. William G KaelinNat Rev Cancer200516110319No
420411161116.0293.3293.3Global incidence and mortality of severe fungal disease. David W DenningLancet Infect Dis202438224705No
420533471115.7106.735.6Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Charalambos Vlachopoulos, Konstantinos Aznaouridis, Christodoulos StefanadisJ Am Coll Cardiol201020338492Yes
420622311115.567.433.7Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R De KloetEndocrinology19852998738Yes
420711151115.037.737.7A cognitive model of insomnia. A G HarveyBehav Res Ther200212186352No
420811151115.037.237.2When does age-related cognitive decline begin? Timothy A SalthouseNeurobiol Aging200919231028Yes
420966881114.7184.730.8Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
421022291114.578.339.1Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
421122291114.570.835.4Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
421233431114.390.530.2Separable dual-space Gaussian pseudopotentials. S Goedecker, M Teter, J HutterPhys Rev B Condens Matter19969986014Yes
421311141114.028.728.7Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
421411141114.024.224.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
421522281114.0108.954.5Development, reliability, and validity of a dissociation scale. E M Bernstein, F W PutnamJ Nerv Ment Dis19863783140Yes
421611141114.042.642.6Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
421711141114.021.721.7Tetraspanin functions and associated microdomains. Martin E HemlerNat Rev Mol Cell Biol200516314869No
421811141114.027.127.1Cooling, heating, generating power, and recovering waste heat with thermoelectric systems. Lon E BellScience200818787160Yes
421911141114.028.328.3Papillomaviruses in the causation of human cancers - a brief historical account. Harald Zur HausenVirology200919135222No
422011141114.054.854.8Depression Is the Leading Cause of Disability Around the World. M J FriedrichJAMA201728418490Yes
422111141114.037.637.6Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
422222271113.548.924.4Drug repositioning: identifying and developing new uses for existing drugs. Ted T Ashburn, Karl B ThorNat Rev Drug Discov200415286734No
422322261113.044.622.3In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KarreImmunol Today19902201309No
422411131113.026.726.7Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
422522261113.039.619.8Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
422611131113.025.225.2Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
422711131113.030.630.6Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Randy L BucknerNeuron200415450170No
422822261113.059.829.9VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. Hanbo Chen, Paul C BoutrosBMC Bioinformatics201121269502Yes
422933381112.7118.839.6DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors. Christopher S McGinnis, Lyndsay M Murrow, Zev J GartnerCell Syst201930954475Yes
423022241112.069.134.5Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
423111121112.022.822.8Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
423211121112.031.831.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
423311121112.027.327.3Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
423411121112.032.832.8Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
423511121112.034.334.3The social brain: neural basis of social knowledge. Ralph AdolphsAnnu Rev Psychol200918771388No
423633361112.081.827.3Triple-negative breast cancer. William D Foulkes, Ian E Smith, Jorge S Reis-FilhoN Engl J Med201021067385No

              Download as CSV


Copyright © 2020-2023 Solid Scientometrics Sp. z o.o.                                         Terms of Service                                                             Designed by Lukasz P. Kozlowski

All information that Unicorn Papers provides is based on PubMed data that are within the public domain. We acknowledge the NCBI, NLM, ORCID and iCite teams.