Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	226872	226872.0	6243.6	6243.6	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	184846	184846.0	6061.8	6061.8	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	146253	73126.5	4024.6	2012.3	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
4	289010	72252.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
5	47253	47253.0	1511.8	1511.8	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	39783	39783.0	1325.2	1325.2	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	64919	32459.5	2017.2	1008.6	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	31141	31141.0	790.8	790.8	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
9	30286	30286.0	791.2	791.2	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
10	30272	30272.0	924.5	924.5	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
11	29585	29585.0	686.4	686.4	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
12	28491	28491.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
13	27285	27285.0	683.3	683.3	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
14	26359	26359.0	851.1	851.1	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
15	25605	25605.0	720.5	720.5	Projector augmented-wave method.	P E Blochl	Phys Rev B Condens Matter	1994	9976227	Yes
16	50276	25138.0	1544.3	772.1	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
17	73051	24350.3	2608.2	869.4	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
18	72005	24001.7	2572.1	857.4	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
19	22681	22681.0	785.8	785.8	Density-functional exchange-energy approximation with correct asymptotic behavior.	A D Becke	Phys Rev A Gen Phys	1988	9900728	Yes
20	66596	22198.7	1626.3	542.1	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
21	42811	21405.5	1376.4	688.2	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
22	42335	21167.5	1313.9	657.0	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
23	21163	21163.0	846.7	846.7	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
24	20985	20985.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
25	41824	20912.0	1664.8	832.4	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
26	61803	20601.0	1900.0	633.3	Generalized Gradient Approximation Made Simple.	J P Perdew, K Burke, M Ernzerhof	Phys Rev Lett	1996	10062328	Yes
27	20583	20583.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
28	38729	19364.5	1004.1	502.1	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
29	38722	19361.0	1865.6	932.8	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
30	19133	19133.0	864.5	864.5	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
31	18993	18993.0	647.8	647.8	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
32	18595	18595.0	866.9	866.9	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
33	53760	17920.0	1605.3	535.1	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
34	35203	17601.5	1434.0	717.0	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
35	17518	17518.0	477.6	477.6	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
36	34866	17433.0	979.8	489.9	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	G Kresse, J Furthmuller	Phys Rev B Condens Matter	1996	9984901	Yes
37	17128	17128.0	679.2	679.2	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
38	33992	16996.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
39	16787	16787.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
40	33569	16784.5	1292.8	646.4	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
41	16575	16575.0	423.8	423.8	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
42	16249	16249.0	433.3	433.3	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
43	16185	16185.0	628.7	628.7	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
44	48177	16059.0	1779.2	593.1	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
45	15948	15948.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
46	47027	15675.7	1414.1	471.4	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
47	30832	15416.0	1144.9	572.5	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
48	15150	15150.0	541.4	541.4	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
49	14789	14789.0	628.5	628.5	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
50	14718	14718.0	375.4	375.4	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
51	29245	14622.5	910.2	455.1	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
52	43749	14583.0	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
53	14416	14416.0	635.0	635.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
54	28739	14369.5	669.6	334.8	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
55	28458	14229.0	604.2	302.1	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
56	70731	14146.2	2101.4	420.3	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
57	13906	13906.0	449.0	449.0	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
58	41335	13778.3	1122.9	374.3	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
59	13746	13746.0	456.5	456.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
60	41058	13686.0	1456.4	485.5	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	C Lee, W Yang, R G Parr	Phys Rev B Condens Matter	1988	9944570	Yes
61	40809	13603.0	1351.6	450.5	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
62	27168	13584.0	1203.0	601.5	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
63	13438	13438.0	227.3	227.3	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
64	13004	13004.0	439.5	439.5	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
65	12853	12853.0	513.4	513.4	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
66	12836	12836.0	587.5	587.5	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
67	12671	12671.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
68	50201	12550.2	1625.4	406.4	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
69	24654	12327.0	559.0	279.5	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
70	11667	11667.0	320.6	320.6	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
71	23117	11558.5	722.9	361.4	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
72	34456	11485.3	1153.6	384.5	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
73	22856	11428.0	981.6	490.8	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
74	11196	11196.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
75	11028	11028.0	309.2	309.2	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
76	10997	10997.0	384.9	384.9	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
77	10991	10991.0	459.6	459.6	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
78	43897	10974.2	1578.4	394.6	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
79	10913	10913.0	468.3	468.3	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
80	32580	10860.0	873.2	291.1	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
81	43423	10855.8	1620.3	405.1	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
82	21560	10780.0	570.9	285.4	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
83	10615	10615.0	265.5	265.5	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
84	21151	10575.5	509.2	254.6	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
85	10569	10569.0	301.2	301.2	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
86	10433	10433.0	274.5	274.5	Canonical dynamics: Equilibrium phase-space distributions.	W G Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
87	20864	10432.0	571.8	285.9	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
88	20830	10415.0	1279.9	640.0	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
89	10384	10384.0	419.2	419.2	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
90	10343	10343.0	222.2	222.2	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
91	10322	10322.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
92	30557	10185.7	1171.1	390.4	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
93	10167	10167.0	306.9	306.9	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
94	20296	10148.0	499.8	249.9	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
95	40327	10081.8	1443.8	360.9	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
96	9965	9965.0	272.0	272.0	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
97	19830	9915.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
98	19805	9902.5	748.7	374.4	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
99	19791	9895.5	509.0	254.5	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
100	9873	9873.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
101	29488	9829.3	769.6	256.5	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
102	19602	9801.0	436.0	218.0	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
103	9781	9781.0	270.9	270.9	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
104	9731	9731.0	328.2	328.2	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
105	9598	9598.0	259.9	259.9	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
106	19150	9575.0	436.9	218.4	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
107	47852	9570.4	1919.5	383.9	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman,	PLoS Med	2009	19621072	No
108	9535	9535.0	264.7	264.7	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
109	28568	9522.7	1442.1	480.7	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
110	9410	9410.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
111	9406	9406.0	293.3	293.3	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
112	9286	9286.0	408.9	408.9	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
113	9252	9252.0	241.9	241.9	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
114	27726	9242.0	964.1	321.4	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
115	9237	9237.0	272.6	272.6	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
116	9179	9179.0	190.5	190.5	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
117	9079	9079.0	242.7	242.7	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
118	9021	9021.0	445.7	445.7	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
119	8985	8985.0	198.6	198.6	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
120	17566	8783.0	416.9	208.4	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
121	8742	8742.0	294.4	294.4	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
122	8596	8596.0	338.2	338.2	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
123	17161	8580.5	600.4	300.2	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
124	17144	8572.0	538.3	269.1	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
125	8567	8567.0	240.7	240.7	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
126	8490	8490.0	280.0	280.0	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
127	8466	8466.0	231.7	231.7	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
128	16833	8416.5	471.9	235.9	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
129	16801	8400.5	462.3	231.2	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
130	8325	8325.0	238.6	238.6	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
131	16605	8302.5	444.0	222.0	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
132	8206	8206.0	177.9	177.9	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
133	8168	8168.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
134	8136	8136.0	152.1	152.1	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
135	8112	8112.0	273.1	273.1	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	J P Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
136	7976	7976.0	264.4	264.4	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
137	7972	7972.0	221.2	221.2	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
138	7923	7923.0	226.2	226.2	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
139	23702	7900.7	693.0	231.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
140	7800	7800.0	224.0	224.0	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
141	7753	7753.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Boyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
142	7743	7743.0	212.0	212.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
143	54091	7727.3	1488.4	212.6	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
144	7701	7701.0	657.2	657.2	Hallmarks of Cancer: New Dimensions.	Douglas Hanahan	Cancer Discov	2022	35022204	No
145	7650	7650.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
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4271	6711	1118.5	184.6	30.8	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
4272	2236	1118.0	39.6	19.8	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
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4276	4471	1117.8	178.7	44.7	Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.	K F Schulz, I Chalmers, R J Hayes, D G Altman	JAMA	1995	7823387	Yes
4277	2235	1117.5	60.0	30.0	Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress.	Ira Tabas, David Ron	Nat Cell Biol	2011	21364565	No
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4279	2234	1117.0	36.6	18.3	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	Lee Zou, Stephen J Elledge	Science	2003	12791985	Yes
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_{Unicorn Papers}

Top ‱ cited papers from PUBMED

Volume 74, October 2026