Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 4176 papers with ECcit ≥ 1097.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 67, March 2026

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1226419226419.04717.94717.9Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2182697182697.07210.37210.3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328835372088.20.00.0Protein measurement with the Folin phenol reagent. O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALLJ Biol Chem195114907713Yes
414012570062.53408.31704.2Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54683146831.01366.91366.9A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63898638986.01250.81250.8Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76478532392.51931.2965.6Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83027130271.0810.5810.5Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92982929829.0688.7688.7MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
102968029680.0931.3931.3The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
112896128961.0623.0623.0MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
122780827808.0706.5706.5A rating scale for depression. M HAMILTONJ Neurol Neurosurg Psychiatry196014399272Yes
132664626646.0599.3599.3A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142570325703.0802.0802.0Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
154803724018.51405.6702.8Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
162393023930.0641.4641.4Projector augmented-wave method. P E BlochlPhys Rev B Condens Matter19949976227Yes
177041923473.02518.5839.5"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
186644822149.31635.0545.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
192210822108.0745.0745.0Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
206525821752.72251.6750.5Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
214211721058.51297.5648.8The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
222061320613.00.00.0Tissue sulfhydryl groups. G L ELLMANArch Biochem Biophys195913650640Yes
232049520495.0203.7203.7The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S REYNOLDSJ Cell Biol196313986422Yes
244012320061.51617.7808.9The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
251996919969.0773.4773.4RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
263919619598.01167.3583.6Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
275801319337.71660.8553.6Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
283813119065.51766.9883.5Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
291849818498.0679.0679.0A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
301849818498.0753.4753.4A power primer. J CohenPsychol Bull199219565683Yes
313640318201.5878.1439.1Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
325368517895.02011.1670.4Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
331738717387.0427.4427.4Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
341734917349.0782.8782.8Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
353381416907.01327.3663.6The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
361677316773.0282.9282.9Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DAVISAnn N Y Acad Sci196414240539Yes
373353816769.00.00.0A rapid method of total lipid extraction and purification. E G BLIGH, W J DYERCan J Biochem Physiol195913671378Yes
381635916359.0624.1624.1Catalase in vitro. H AebiMethods Enzymol19846727660Yes
393257216286.0863.2431.6Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmullerPhys Rev B Condens Matter19969984901Yes
401627616276.0388.5388.5MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
411622916229.0442.4442.4High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
423240616203.01200.0600.0Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
431594015940.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BURTONBiochem J195613293190Yes
444658715529.01318.1439.4CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
451476814768.0550.2550.2Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
464423814746.01584.6528.2Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
474332914443.00.00.0A simple method for the isolation and purification of total lipides from animal tissues. J FOLCH, M LEES, G H SLOANE STANLEYJ Biol Chem195713428781Yes
481414114141.0339.6339.6Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
491401614016.0460.8460.8Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
502791913959.5994.5497.2MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
512776513882.5734.4367.2Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
522763713818.5550.9275.4Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
536873513747.01959.0391.8Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
541365213652.0612.3612.3Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
551355513555.0406.6406.6Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
561337013370.0398.4398.4The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
572660813304.0562.2281.1KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
583989513298.31375.8458.6Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
592653813269.01066.3533.1The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
601321513215.0544.5544.5Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
611304713047.0151.2151.2The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
623885212950.7998.3332.8VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
633802812676.01203.4401.1NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
641266312663.00.00.0Phosphorus assay in column chromatography. G R BARTLETTJ Biol Chem195913641241Yes
651266212662.0412.3412.3Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
661228612286.0459.0459.0A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
674771011927.51327.1331.8Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
682385311926.5511.8255.9Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
691179711797.0521.6521.6SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
701122311223.0280.6280.6Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
712238911194.5928.0464.0The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
721090010900.0352.0352.0Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
731085010850.00.00.0On the origin of cancer cells. O WARBURGScience195613298683Yes
742156410782.0555.3277.6A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
751052710527.0440.8440.8Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
761047910479.0284.2284.2The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
773129710432.3894.1298.0The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
782079010395.0604.3302.1AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
794156910392.21500.2375.1A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
804135210338.01317.7329.4Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
811031410314.0196.3196.3Improvements in epoxy resin embedding methods. J H LUFTJ Biophys Biochem Cytol196113764136Yes
821028810288.0291.4291.4Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
833064610215.3770.6256.9edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
841015310153.0204.1204.1Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
851006610066.0234.2234.2PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
862002910014.5505.7252.8Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
8799479947.0254.7254.7Canonical dynamics: Equilibrium phase-space distributions. WG HooverPhys Rev A Gen Phys19859895674Yes
88198219910.5356.5178.2The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
8999079907.0272.7272.7Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
9098469846.0383.4383.4UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
91195409770.0501.8250.9A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
92194419720.5440.2220.1BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
9396729672.0242.3242.3RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
9496679667.0316.8316.8Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
95193059652.5393.3196.7The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
96287789592.7700.0233.3Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9795739573.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
9895719571.0240.9240.9Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
9995389538.0251.2251.2Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
10093929392.0382.0382.0Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
101186849342.0393.6196.8Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10292659265.0237.0237.0Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
10392549254.0261.0261.0Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
104461919238.21694.8339.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, PLoS Med200919621072No
105369279231.81173.8293.4G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
10692209220.0257.5257.5The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
107183509175.0596.0298.0Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
108182849142.0417.2208.6WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
10990969096.0231.5231.5Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
11090749074.0263.3263.3AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
11190619061.0177.2177.2Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
112271799059.71321.5440.5MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
113181019050.51073.7536.9A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
11490469046.00.00.0The assessment of anxiety states by rating. M HAMILTONBr J Med Psychol195913638508Yes
11588168816.0182.0182.0The functions of animal microRNAs. Victor AmbrosNature200415372042No
116262488749.3887.1295.7Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
117261298709.7769.7256.6Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
11887068706.0395.0395.0Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
119170338516.5378.3189.2Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
12084738473.0351.3351.3Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
12183658365.0226.1226.1Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
12282198219.0197.7197.7Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
123163758187.5391.2195.6MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
12481508150.0197.4197.4Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
12581348134.0251.6251.6The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
12680888088.0277.9277.9The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
12780348034.0164.8164.8Chromatin modifications and their function. Tony KouzaridesCell200717320507No
12880318031.0155.4155.4Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
129159887994.0436.0218.0EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
13079397939.0218.1218.1"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
13179307930.0256.7256.7Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
13278897889.0225.8225.8A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
13378727872.0252.9252.9An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
13478247824.0232.5232.5The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
135234477815.7904.9301.6Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
13678087808.0214.6214.6The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
137155927796.0410.7205.3RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
13877647764.0197.6197.6A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
13977397739.0222.9222.9Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BoyumScand J Clin Lab Invest Suppl19684179068Yes
14077267726.0218.4218.4Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
141154077703.5390.7195.3Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
142534687638.31356.0193.7Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
143150047502.0504.2252.1Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
14474137413.0119.0119.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
14572387238.00.00.0Index for rating diagnostic tests. W J YOUDENCancer195015405679Yes
146143217160.5773.2386.6Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14770927092.0190.9190.9TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
148140447022.0349.4174.7Continuous cultures of fused cells secreting antibody of predefined specificity. G Kohler, C MilsteinNature19751172191Yes
14970057005.0116.6116.6A Self-Rating Depression Scale. W W ZUNGArch Gen Psychiatry196514221692Yes
15069606960.0205.7205.7Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
15168706870.0183.1183.1The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
15268676867.0155.5155.5Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
15368676867.0132.5132.5Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
15467496749.0217.5217.5Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
15567466746.0153.7153.7Inflammation, atherosclerosis, and coronary artery disease. Goran K HanssonN Engl J Med200515843671No
156134506725.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N MANTEL, W HAENSZELJ Natl Cancer Inst195913655060Yes
15767176717.0230.1230.1FreeSurfer. Bruce FischlNeuroimage201222248573No
15867156715.00.00.0The thiobarbituric acid assay of sialic acids. L WARRENJ Biol Chem195913672998Yes
15966996699.0155.3155.3Inflammation and metabolic disorders. Gokhan S HotamisligilNature200617167474No
160133796689.5303.3151.7Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
161133786689.0448.8224.4The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
162398996649.81329.9221.7Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
16366246624.0285.1285.1Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
164198186606.0552.3184.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
16566046604.0168.9168.9Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
16665796579.0169.6169.6Adhesion receptors of the immune system. T A SpringerNature19901974032No
167197156571.7973.8324.6Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16865476547.0150.1150.1Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
169130466523.0517.1258.6Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
17065066506.0574.5574.5Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
17164876487.0148.0148.0Free radicals in the physiological control of cell function. Wulf DrogePhysiol Rev200211773609No
17264726472.0137.3137.3Inflammation in atherosclerosis. Peter LibbyNature200212490960No
17364586458.0135.3135.3p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
17464396439.0117.2117.2BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
17564256425.0129.0129.0Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
17663796379.0171.6171.6A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
17763726372.0203.8203.8Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
17863656365.0141.7141.7Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
179127106355.0340.7170.3Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
180253346333.5722.8180.7clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
18162706270.0140.8140.8Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
182125226261.0477.5238.8phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
183124876243.5264.5132.2One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
184124546227.0283.0141.5Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
185186686222.7571.5190.5featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
18662226222.078.778.7The Environment And Disease: Association Or Causation? A B HILLProc R Soc Med196514283879Yes
18762116211.0134.4134.4MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
188124096204.5296.9148.4MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
18961476147.0185.9185.9Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
190122866143.0441.0220.5A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
19160946094.0152.6152.6G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
19260856085.0146.6146.6Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
19360656065.0151.2151.2Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
19460276027.0155.1155.1How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
195240316007.8704.0176.0A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
196239745993.5781.9195.5Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
197239365984.0575.1143.8Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
198119445972.0392.7196.3Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
199119425971.0249.8124.9MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jurgen Cox, Matthias MannNat Biotechnol200819029910Yes
20059165916.0151.2151.2Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
201117945897.0284.6142.3Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
20258965896.0142.1142.1Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
20358835883.0178.7178.7jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
20458665866.0231.3231.3Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
205117195859.5241.5120.8Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
20658335833.00.00.0Aging: a theory based on free radical and radiation chemistry. D HARMANJ Gerontol195613332224Yes
20758075807.0218.3218.3The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
208174195806.3640.1213.4The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
20957995799.0215.2215.2Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
210114995749.5247.2123.6Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
211114735736.5300.8150.4Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
21257355735.0119.2119.2Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
21357355735.0142.1142.1Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
214114635731.5708.1354.1Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
215114545727.0193.496.7The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T OMURA, R SATOJ Biol Chem196414209971Yes
216114345717.0532.0266.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
21757145714.095.395.3Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
218114145707.00.00.0A series of normal stages in the development of the chick embryo. V HAMBURGER, H L HAMILTONJ Morphol195124539719Yes
21956235623.0164.7164.7Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
22056215621.089.789.7Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
221168515617.0653.7217.9Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
222168345611.3656.8218.9A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
223112175608.5255.2127.6A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stephane Guindon, Olivier GascuelSyst Biol200314530136Yes
22456015601.0118.6118.6The biochemistry of apoptosis. M O HengartnerNature200011048727No
22556005600.0245.5245.5Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniel LakensFront Psychol201324324449No
226167725590.7502.2167.4A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
227111405570.00.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L HODGKIN, A F HUXLEYJ Physiol195212991237Yes
228166515550.3403.7134.6Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
229110295514.5363.0181.5Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
230109355467.5284.8142.4Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
23154515451.0103.1103.1Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
23254235423.053.653.6The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LAURENActa Pathol Microbiol Scand196514320675Yes
233108255412.5299.9149.9MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
23453985398.0135.3135.3The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
23553885388.0128.0128.0Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
23653875387.0104.5104.5Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
237107705385.0227.6113.8The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
238161455381.7560.3186.8HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
239269005380.0719.7143.9The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
24053495349.0127.3127.3The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
241106945347.0251.7125.8Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
24253105310.0134.8134.8New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
243105685284.0181.690.8Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
24452725272.0151.4151.4Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
24552695269.0158.4158.4Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
246105105255.0167.283.6Functional Evaluation: The Barthel Index. F I MAHONEY, D W BARTHELMd State Med J196514258950Yes
24752395239.0188.5188.5Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
24852215221.00.00.0[A micro-method of immuno-electrophoresis]. J J SCHEIDEGGERInt Arch Allergy Appl Immunol195513262900Yes
249104235211.5364.3182.2The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
25052055205.068.468.4Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
251156005200.0508.1169.4HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
252103935196.5361.7180.8Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
25351855185.0101.6101.6Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
254103065153.0264.7132.3The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
255102915145.5272.0136.0Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schagger, G von JagowAnal Biochem19872449095Yes
256205775144.2635.4158.8A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LoweArch Intern Med200616717171Yes
25751215121.0188.4188.4Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
25851185118.0144.4144.4Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
259102145107.0238.5119.2A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
260153125104.0480.5160.2Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
261255045100.81023.1204.6MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
26250985098.0113.7113.7The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
263152765092.0662.3220.8Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
264253425068.4414.182.8An inventory for measuring depression. A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGHArch Gen Psychiatry196113688369Yes
26550565056.091.791.7DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
266100105005.0224.3112.2Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
267150025000.7540.5180.2Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
268199324983.0310.177.5A new and rapid colorimetric determination of acetylcholinesterase activity. G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONEBiochem Pharmacol196113726518Yes
26949724972.0114.8114.8Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
27099134956.5360.5180.2The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
27149494949.0123.3123.3A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
27249124912.0156.0156.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
273343004900.0741.1105.9UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
27448964896.097.497.4An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
27597874893.5395.9197.9The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
27697854892.5348.6174.3Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
27797854892.5243.1121.5Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
278146614887.0392.5130.8Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
27997684884.0230.2115.1Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
28048714871.0203.6203.6The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
28148564856.0131.7131.7Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
28248524852.0104.3104.3Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
283145254841.70.00.0Determination of serum proteins by means of the biuret reaction. A G GORNALL, C J BARDAWILL, M M DAVIDJ Biol Chem194918110453Yes
28448234823.0107.3107.3ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
28548214821.040.940.9The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HAYFLICKExp Cell Res196514315085Yes
28648174817.0104.5104.5Cancer cell cycles. C J SherrScience19968939849No
28796324816.0365.4182.7The qualitative content analysis process. Satu Elo, Helvi KyngasJ Adv Nurs200818352969Yes
288144444814.7355.7118.6A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
28948064806.0104.5104.5Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
29048054805.057.457.4Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RODBELLJ Biol Chem196414169133Yes
29147974797.0138.8138.8DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
292143484782.7309.4103.1Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
293238834776.6901.8180.4The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
29495424771.00.00.0Radiological assessment of osteo-arthrosis. J H KELLGREN, J S LAWRENCEAnn Rheum Dis195713498604Yes
29547684768.094.894.8Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
29695334766.5155.377.7A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
29747584758.0145.0145.0Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
29894754737.5236.9118.5Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
29994514725.5257.2128.6Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
30047174717.0265.0265.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BORNNature196213871375Yes
30147074707.0155.8155.8The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
30294044702.0136.668.3Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
30346924692.049.149.1The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
30446914691.096.196.1Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
30593804690.0229.7114.8Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30646884688.0173.9173.9Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
307187164679.0519.0129.8MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
30846784678.0129.5129.5Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
30946624662.0120.4120.4A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
31093204660.0292.5146.2FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoc, Steven L SalzbergBioinformatics201121903629Yes
31192934646.5202.7101.3Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
31246434643.0165.6165.6EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31346404640.091.491.4Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
31446394639.0126.4126.4Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
31546154615.0104.4104.4Cancer. p53, guardian of the genome. D P LaneNature19921614522No
31692144607.0264.2132.1Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
317137744591.3499.9166.6A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
318137444581.3469.7156.6Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
31991394569.5241.8120.9A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
32091264563.0208.8104.4SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
32145564556.096.896.8ras genes. M BarbacidAnnu Rev Biochem19873304147No
32245544554.0164.4164.4A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
32345534553.086.986.9The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
32445394539.091.091.0Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
32545384538.084.584.5The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
32645134513.0106.5106.5Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
32745094509.0135.1135.1How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
32845044504.0112.4112.4Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
32945024502.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B DE B WEIRJ Physiol194915394301Yes
33044954495.0112.4112.4Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
33189864493.0209.5104.8Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
332268904481.7865.8144.3Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
33344734473.0113.1113.1A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
33444634463.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
33544534453.091.691.6Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
33644414441.0113.1113.1Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33788824441.00.00.0A simplified method of evaluating dose-effect experiments. J T LITCHFIELD, F WILCOXONJ Pharmacol Exp Ther194918152921Yes
338177584439.5790.4197.6fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
33944384438.0107.3107.3A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
34044184418.0101.9101.9Mechanisms of angiogenesis. W RisauNature19979109485No
341264724412.0912.0152.0MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
34244114411.093.293.2Atherosclerosis. A J LusisNature200011001066No
34387714385.5162.081.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
344218824376.41244.1248.8MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
345436854368.51055.1105.5The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, Bioinformatics200919505943Yes
34687274363.5266.6133.3DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
34787254362.5221.3110.7tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
34843554355.0224.9224.9Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
34987044352.0216.7108.3Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
35043494349.0111.1111.1Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
35143454345.0128.3128.3Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
35243444344.0119.5119.5The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
35343424342.0107.3107.3Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
35486384319.0226.6113.3Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35543044304.094.194.1PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
35642994299.0113.7113.7Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
35742944294.0121.8121.8Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
35842924292.0142.5142.5Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
35985834291.5454.8227.4Preparation of iodine-131 labelled human growth hormone of high specific activity. W M HUNTER, F C GREENWOODNature196214450081Yes
36042884288.087.687.6The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
36142834283.0172.2172.2A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
36242824282.091.691.6Apoptosis by death factor. S NagataCell19979039262No
36342784278.00.00.0Estimation of nuclear population from microtome sections. M ABERCROMBIEAnat Rec194621015608Yes
36442744274.0112.7112.7The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
36542734273.075.475.4Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
36642704270.0101.1101.1RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
36742664266.0148.9148.9KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
36842644264.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NASHBiochem J195313105648Yes
36942624262.0120.7120.7Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
37042574257.072.572.5Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
37142534253.0100.9100.9The origins and the future of microfluidics. George M WhitesidesNature200616871203No
37285064253.0180.090.0Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
37342514251.00.00.0Amino acid metabolism in mammalian cell cultures. H EAGLEScience195913675766Yes
37442484248.050.250.2Bone: formation by autoinduction. M R UristScience19655319761Yes
37542484248.086.686.6The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
37642414241.0111.3111.3Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
37742404240.0108.3108.3Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
37842394239.080.580.5Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
37942224222.093.793.7Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
380168434210.8588.6147.2Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
38142094209.0175.2175.2Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
38284054202.5216.7108.3Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
38342024202.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DOLEJ Clin Invest195613286333Yes
384125974199.0319.0106.3Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
38541994199.086.586.5Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
38641984198.086.886.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
38783814190.5194.197.0The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
38841804180.071.171.1Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
38941774177.0115.4115.4EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
39041684168.00.00.0The determination of enzyme inhibitor constants. M DIXONBiochem J195313093635Yes
39141644164.0111.7111.7Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
392166354158.8367.391.8Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
39341534153.0128.0128.0Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
39441474147.0102.4102.4Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39582824141.0177.188.5Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
39641364136.0100.9100.9Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
39740964096.0134.3134.3Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
39881864093.0195.597.8The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
39940914091.0106.8106.8Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
40040904090.091.791.7Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
40181284064.0199.199.5An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
402364994055.41090.0121.1STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
403121594053.0283.494.5Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
40440464046.0115.7115.7adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
405121354045.0323.2107.7Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
40680784039.0151.976.0Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
40740394039.082.182.1Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
408282644037.7965.1137.9limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
40980674033.5151.775.8A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
41040294029.0102.9102.9Integrins: a family of cell surface receptors. R O HynesCell19873028640No
41140284028.0144.1144.1You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
41240264026.082.282.2Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41340224022.0106.7106.7What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
41440064006.0127.8127.8Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
41540054005.087.487.4Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
416120094003.0377.1125.7Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
41779823991.0260.2130.1Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
41839903990.0113.5113.5What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41979703985.0212.3106.2BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
420159403985.0642.1160.5IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
42139753975.094.694.6Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
42239733973.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WATSONJ Biophys Biochem Cytol195813563554Yes
42339633963.092.792.7Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
42439563956.0119.0119.0Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
42539543954.0117.8117.8Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
426354853942.8752.183.6Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
42739293929.095.295.2How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
42878503925.0218.9109.5Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
42939243924.0110.1110.1Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
43039233923.0120.2120.2Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
43139223922.0102.8102.8Graphene: status and prospects. A K GeimScience200919541989Yes
43239213921.0143.4143.4Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
43339153915.064.064.0Disc Electrophoresis. I. Background And Theory. L ORNSTEINAnn N Y Acad Sci196414240533Yes
43439143914.076.176.1Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
43539033903.0177.0177.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
43639013901.090.490.4I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
43739003900.0118.7118.7genepop'007: a complete re-implementation of the genepop software for Windows and Linux. Francois RoussetMol Ecol Resour200821585727Yes
43838893889.088.888.8Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
43938883888.091.091.0Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
44038853885.098.998.9The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
44138823882.0125.7125.7Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
44238753875.099.299.2The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
44377433871.5425.2212.6The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
44477353867.5177.788.8Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
445115873862.31049.9350.0MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
44638483848.0122.0122.0No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
44776903845.0227.5113.8Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
44838413841.0121.0121.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
44938353835.0102.2102.2Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
45076383819.0180.890.4Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
45138193819.077.477.4TGF-beta signal transduction. J MassagueAnnu Rev Biochem19989759503No
45238103810.089.789.7Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrungerNature199218481394Yes
45338093809.098.698.6Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
45438003800.079.479.4A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
45538003800.091.691.6The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
45675893794.5163.881.9Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
45775863793.0381.4190.7Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
458151163779.0843.5210.9Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
45975553777.5235.0117.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
46075493774.5275.6137.8The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
46137623762.0167.3167.3The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
46237583758.065.165.1Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
46337563756.066.166.1Somatic generation of antibody diversity. S TonegawaNature19836300689No
46437543754.0107.2107.2Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
465112513750.3258.786.2Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
466112343744.7213.871.3Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
46737283728.076.876.8Profile hidden Markov models. S R EddyBioinformatics19989918945No
46837083708.0101.7101.7Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
46937043704.068.468.4A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
470184553691.0656.8131.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Ann Intern Med200919622511No
471110703690.0256.185.4ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
472110683689.3259.786.6Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
47336733673.0115.8115.8Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
47436713671.0118.2118.2The Danish Civil Registration System. Carsten Bocker PedersenScand J Public Health201121775345Yes
47536683668.0101.5101.5Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
47636683668.0125.5125.5Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
47736653665.081.481.4Glutamate uptake. N C DanboltProg Neurobiol200111369436No
47836563656.0126.7126.7Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
47936543654.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MILLERPsychol Rev195613310704Yes
48073023651.0128.864.4Translating the histone code. T Jenuwein, C D AllisScience200111498575No
48172973648.5170.085.0Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
48236433643.0167.4167.4Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
483109233641.0296.999.0GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hanzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
48436403640.071.171.1Mammalian neural stem cells. F H GageScience200010688783No
48536343634.079.979.9Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
48672643632.0350.8175.4Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H HUBEL, T N WIESELJ Physiol196214449617Yes
48736313631.084.084.0Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
48836243624.053.953.9Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
48936243624.0134.2134.2Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
49072413620.5203.4101.7The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
491398073618.8808.873.5Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
49236133613.0106.6106.6Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
49336133613.0184.1184.1High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
49436123612.0140.0140.0Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
49572233611.5584.8292.4Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
49636113611.0108.2108.2Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
49736113611.067.167.1Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
49872193609.5199.799.8Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
49972173608.5208.6104.3The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
50072063603.0138.069.0Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
50136013601.091.991.9Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
50235943594.085.885.8The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
50335863586.076.576.5Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
50435593559.085.985.9The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
50535563556.0140.9140.9Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
506177403548.0614.1122.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, BMJ200919622551No
50770803540.0145.172.5A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
50870713535.5133.166.5The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50935353535.0164.1164.1Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
51035343534.0110.1110.1Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
51170573528.5210.5105.2Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51235283528.057.057.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
51335223522.094.594.5Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
51435213521.051.251.2The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WOESSNERArch Biochem Biophys196113786180Yes
515176003520.0493.898.8Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
51670283514.0161.580.8Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
51770233511.5194.097.0Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
51835113511.077.577.5Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
51935103510.0149.8149.8Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
52035093509.087.487.4Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
52135053505.083.283.2Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
52234953495.069.669.6Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
52369863493.0183.291.6Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52434873487.080.080.0The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
52534873487.057.557.5Statistical estimations in enzyme kinetics. G N WILKINSONBiochem J196113785321Yes
52634813481.094.494.4Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
52769493474.5172.886.4The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
52834743474.065.565.5The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
52969463473.0181.690.8Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
53034693469.082.582.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
53169383469.0143.271.6Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
532276733459.1586.373.3The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
53334553455.076.976.9Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
53434533453.070.570.5Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53568853442.5171.485.7TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
53634423442.091.791.7Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
53768783439.0162.381.2"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
53868763438.0214.3107.2Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
53968643432.0205.8102.9Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
54034253425.00.00.0Some factors in the interpretation of protein denaturation. W KAUZMANNAdv Protein Chem195914404936Yes
54134103410.0177.8177.8Obesity: global epidemiology and pathogenesis. Matthias BluherNat Rev Endocrinol201930814686No
54268053402.5219.0109.5Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
543101903396.7279.993.3Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
54467923396.0212.0106.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
54567893394.5161.780.8In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
54633933393.068.768.7Protein folding and misfolding. Christopher M DobsonNature200314685248No
54733903390.0113.5113.5Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
548101703390.0282.394.1FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
549101593386.398.332.8The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C GREENWOOD, W M HUNTER, J S GLOVERBiochem J196314097352Yes
55033803380.076.576.5Photoelectrochemical cells. M GratzelNature200111713540Yes
55167413370.5185.993.0mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
55233693369.068.568.5The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
55367383369.056.128.1The serial cultivation of human diploid cell strains. L HAYFLICK, P S MOORHEADExp Cell Res196113905658Yes
55467353367.5271.4135.7GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
55533673367.0100.6100.6Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
55633673367.0103.6103.6Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
55733583358.060.360.3Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
55833513351.0106.8106.8What is value in health care? Michael E PorterN Engl J Med201021142528Yes
559100503350.0476.7158.9Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
56066933346.5103.952.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
56133423342.095.795.7Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
56233403340.075.475.4Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
56333383338.067.967.9Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
56433333333.088.088.0ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
56566603330.0163.281.6Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
56633253325.078.278.2Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
56733213321.097.397.3The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
56833193319.051.751.7A Rationale And Test For The Number Of Factors In Factor Analysis. J L HORNPsychometrika196514306381Yes
569199003316.7940.0156.7DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
57033153315.0162.1162.1Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
57199433314.3183.061.0Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
57233073307.083.683.6Gene regulation by steroid hormones. M BeatoCell19892644044No
573132273306.8492.1123.0APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
57433033303.075.175.1The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57533033303.071.471.4Calcium signaling. David E ClaphamCell200718083096No
57633013301.0111.5111.5The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
57733003300.069.669.6Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
57832993299.046.246.2Equilibrium Ultracentrifugation Of Dilute Solutions. D A YPHANTISBiochemistry196414155091Yes
57932983298.0127.0127.0Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
58065923296.0162.881.4Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
58132943294.064.164.1STATs and gene regulation. J E DarnellScience19979287210No
58232853285.066.866.8TGFbeta in Cancer. Joan MassagueCell200818662538No
58398533284.3413.7137.9Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
58432833283.087.487.4Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
58565473273.5302.2151.1Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
58632623262.066.166.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
58732563256.066.166.1Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
58832523252.0111.1111.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
589130053251.2297.974.5Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
59032483248.093.193.1Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
59132483248.059.259.2Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
59264813240.5133.366.7Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
59332373237.026.926.9Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LYONNature196113764598Yes
59432373237.072.072.0T cell exhaustion. E John WherryNat Immunol201121739672No
59532303230.0106.3106.3Measurement of pain. E C HuskissonLancet19744139420Yes
59632303230.0107.2107.2The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
597129103227.5361.790.4Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
59864493224.5110.455.2The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
59932193219.0143.0143.0The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
60032183218.097.597.5A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
60132173217.066.266.2Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
60232103210.073.873.8Obesity as a medical problem. P G KopelmanNature200010766250No
60332073207.087.187.1The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
60464133206.5140.970.5Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
60563963198.0163.681.8Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
60631923192.073.773.7MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
60731913191.0126.6126.6Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
60863663183.0135.167.5MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
60963643182.0132.466.2Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
61031803180.068.968.9Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61195253175.0236.178.7Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
61231743174.074.374.3WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
61395173172.3192.864.3Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
61463433171.5149.074.5Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
61563433171.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S REITMAN, S FRANKELAm J Clin Pathol195713458125Yes
61631693169.077.777.7The transforming growth factor-beta family. J MassagueAnnu Rev Cell Biol19902177343No
61731653165.074.274.2Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
61831633163.085.285.2Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
61931523152.0113.9113.9Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
62031423142.00.00.0Diffusion-in-gel methods for immunological analysis. O OUCHTERLONYProg Allergy195813578996Yes
62131393139.073.473.4Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
62231343134.094.794.7The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
62331303130.093.693.6Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
62493833127.7310.9103.6Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
62593353111.7214.771.6The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62693303110.0298.599.5Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
62762093104.5126.063.0Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62892823094.0203.267.7TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
62930913091.059.759.7Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
630123493087.2283.670.9Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
63161703085.0193.096.5Extracellular vesicles: exosomes, microvesicles, and friends. Graca Raposo, Willem StoorvogelJ Cell Biol201323420871No
63261683084.0146.173.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
63330843084.0130.3130.3Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
63430683068.070.170.1Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
63530683068.029.629.6Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MITCHELLNature196113771349Yes
63630663066.084.784.7Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
63730663066.047.447.4A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HAKOMORIJ Biochem196414135466Yes
63830573057.0129.7129.7Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
63930573057.089.589.5SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
64030563056.074.174.1Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
64161093054.5187.893.9Tissue engineering. R Langer, J P VacantiScience19938493529No
64230523052.095.195.1An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
64330493049.056.056.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64430453045.054.954.9RNA interference. Gregory J HannonNature200212110901No
64530423042.066.266.2Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
64691233041.0174.958.3Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
64730363036.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SELDINGERActa Radiol (Stockh)195313057644Yes
64830333033.00.00.0The genetical structure of populations. S WRIGHTAnn Eugen195124540312Yes
64960573028.5234.9117.5Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
65030243024.084.284.2Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
65130203020.093.293.2Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
65230163016.070.570.5Structure and function of telomeres. E H BlackburnNature19911708110No
65330153015.056.756.7Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65430133013.0132.9132.9The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
65530123012.00.00.0A study of fixation for electron microscopy. G E PALADEJ Exp Med195214927794Yes
65660093004.5173.987.0Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
65730043004.057.457.4Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65859972998.5168.184.0Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
65929982998.068.068.0Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
66089802993.3195.165.0Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
66159812990.5177.488.7Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66259772988.5201.6100.8The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
66359722986.0196.498.2Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
66459692984.5180.190.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
66529842984.073.373.3Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
66659662983.0124.962.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
66729812981.091.091.0Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
66829812981.061.461.4Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
66929752975.051.851.8The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
67029712971.073.173.1The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67188822960.7241.780.6Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
67229572957.061.861.8Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
673177422957.0379.763.3Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
67429522952.059.159.1A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
67529522952.044.344.3Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
67629502950.076.276.2The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
67758992949.5125.162.5Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
67829452945.060.460.4Principles of CDK regulation. D O MorganNature19957877684No
67929452945.069.269.2Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
68029432943.078.278.2Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
68129392939.052.552.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
68258782939.0130.565.2Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
68329382938.074.174.1Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68429372937.095.495.4Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
68529362936.048.848.8Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
68629312931.086.786.7Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
68729292929.087.287.2Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
68829222922.0113.7113.7What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
68987452915.00.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J HAVEL, H A EDER, J H BRAGDONJ Clin Invest195513252080Yes
69058282914.0161.580.8Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
69158262913.0154.577.2Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69229122912.070.770.7Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
69358192909.5249.7124.8Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
69487032901.0346.0115.3Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
69529002900.095.295.2Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
69658002900.0149.274.6Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
69728982898.061.061.0Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
69828942894.0128.5128.5Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
69928942894.00.00.0Notes on sugar determination. M SMOGYIJ Biol Chem195214938350Yes
70057872893.5195.597.8A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
70157842892.0115.457.7Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
70257792889.5173.386.7Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
70328892889.048.648.6A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GEHANBiometrika196514341275Yes
70428832883.083.883.8Separation of leukocytes from blood and bone marrow. Introduction. A BoyumScand J Clin Lab Invest Suppl19685707208Yes
70557662883.0111.255.6Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
70628832883.085.185.1Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
70728792879.072.572.5Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
70886292876.3425.6141.9SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
70928752875.050.550.5One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
71028742874.092.692.6A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
71128702870.069.569.5Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
71286052868.3224.574.8Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
71357322866.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D WATSON, F H CRICKNature195313054692Yes
71428612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SCHNEIDERJ Biol Chem194521005736Yes
71528592859.082.982.9Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
71657122856.0180.890.4The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
71785582852.7246.982.3Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
71828472847.00.00.0A study of the adrenotropic receptors. R P AHLQUISTAm J Physiol194818882199Yes
71928462846.065.565.5An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
72028432843.056.956.9Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
72128412841.064.264.2Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
72256812840.5203.3101.7Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
72328392839.096.596.5Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
72428372837.064.364.3Memory--a century of consolidation. J L McGaughScience200010634773No
72556722836.0174.287.1Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
72628332833.0111.0111.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
72728302830.066.266.2P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
72856562828.0158.879.4Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
72928262826.065.365.3Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
73056512825.5135.968.0Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
73128252825.0111.9111.9Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
732112972824.2262.665.7Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
73356422821.0134.067.0Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
73484572819.0214.971.6Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
73556342817.0132.666.3Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
73628142814.0146.0146.0Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
73728122812.0108.7108.7Metazoan MicroRNAs. David P BartelCell201829570994No
73856232811.5125.462.7Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
73928092809.098.898.8Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
74056132806.5315.6157.8A modified uronic acid carbazole reaction. T BITTER, H M MUIRAnal Biochem196213971270Yes
74128062806.066.666.6A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
74256112805.5151.976.0The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
74328022802.052.952.9The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
74428022802.023.723.7Satellite cell of skeletal muscle fibers. A MAUROJ Biophys Biochem Cytol196113768451Yes
74527982798.061.461.4Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
746111902797.5319.479.8Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
74783852795.0240.480.1Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
74827952795.0102.6102.6Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
74927942794.068.768.7Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
75027942794.061.961.9Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
75127942794.070.770.7Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
75227932793.061.061.0Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
75383782792.7208.069.3Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
75455802790.076.038.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G MARTIN, B N AMESJ Biol Chem196113767412Yes
755111532788.2321.680.4Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
75655742787.0125.762.9A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
75755712785.5167.583.8Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
75827852785.087.887.8Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
75927852785.075.475.4Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
760111342783.5293.073.2Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
76155642782.0159.980.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
76227822782.061.761.7Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
76327812781.060.460.4On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
76427772777.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
76555532776.5109.354.6Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J SILNESS, H LOEActa Odontol Scand196414158464Yes
76627592759.065.765.7Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
76782712757.0328.4109.5Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
76855092754.5217.9109.0A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
76927532753.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SVENNERHOLMBiochim Biophys Acta195713436486Yes
77027532753.050.550.5Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
77155052752.5143.771.8Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
77282572752.3195.865.3RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
77327512751.067.867.8A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
77454952747.5137.668.8UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
77527472747.082.982.9Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
77627462746.0173.1173.1User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
77727452745.097.397.3UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
778438992743.71333.483.3Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
77954862743.0119.459.7Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
78054832741.5107.753.9High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
78154822741.0132.766.3ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
78227402740.0108.6108.6Deep learning in neural networks: an overview. Jurgen SchmidhuberNeural Netw201525462637No
78327372737.074.274.2Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
78427312731.058.458.4The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
78527302730.056.656.6Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
78627292729.055.255.2Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
78754572728.5109.654.8MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
78854542727.0102.951.5Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
78954512725.5234.2117.1Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
79054462723.0171.085.5PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
79181512717.0174.258.1Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
79254252712.5131.265.6A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
793108452711.2226.156.5Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
79427072707.082.882.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
79554092704.5156.478.2SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
79626992699.063.563.5Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
79726992699.065.165.1MYC on the path to cancer. Chi V DangCell201222464321No
79826982698.056.056.0Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
79926972697.074.474.4Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
80053862693.0172.986.5The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
80126932693.051.051.0Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
80253812690.5173.286.6Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
80326882688.061.661.6Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
80453762688.0112.356.1Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
80553662683.072.636.3A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
80680372679.0194.764.9MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
80780352678.3208.369.4trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni GabaldonBioinformatics200919505945Yes
80826782678.077.277.2Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
80926772677.070.570.5Dominant forces in protein folding. K A DillBiochemistry19902207096No
81026712671.071.871.8Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
81126692669.050.150.1Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
81226652665.072.972.9Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
81326642664.0109.0109.0The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
81426632663.055.555.5Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
81526622662.066.066.0The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
81653232661.5155.377.7Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
81726602660.059.259.2Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
81853192659.5127.063.5The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
819106382659.5264.566.1GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
82026552655.087.287.2Working memory. A BaddeleyScience19921736359No
82126492649.0108.2108.2The biology of oxygen radicals. I FridovichScience1978210504Yes
82252952647.5138.369.2Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
82326412641.056.856.8The inflammatory reflex. Kevin J TraceyNature200212490958No
82426412641.076.276.2PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
82526392639.0133.4133.4The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
82626302630.072.672.6Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
82752502625.0116.458.2Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
82826252625.0116.5116.5Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82952492624.5160.780.3The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
83026232623.062.162.1Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
83152422621.00.00.0Some quantitative uses of drug antagonists. O ARUNLAKSHANA, H O SCHILDBr J Pharmacol Chemother195913651579Yes
83226172617.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
83326152615.035.435.4The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
83452292614.5180.090.0A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
83552242612.0102.451.2Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
836104472611.8219.754.9MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
83778352611.7216.172.0Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
83852222611.0111.755.9Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
83926112611.070.470.4Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
84026042604.081.581.5Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
84126012601.080.580.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
84225982598.055.055.0G1 phase progression: cycling on cue. C J SherrCell19947954821No
84325862586.073.373.3Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
84451682584.0139.269.6The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
84525822582.061.361.3Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
84625772577.0104.0104.0The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
84751542577.0219.5109.8The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
84825732573.068.168.1TGFβ signalling in context. Joan MassagueNat Rev Mol Cell Biol201222992590No
84925702570.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PORTERBiochem J195914434282Yes
85025692569.0120.5120.5The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
85151352567.5147.974.0Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
85251312565.5132.866.4Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
85325642564.074.874.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
85451222561.0277.2138.6A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
85525602560.0126.6126.6The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BOYDENJ Exp Med196213872176Yes
85625572557.080.780.7Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
85725552555.077.177.1A two process model of sleep regulation. A A BorbelyHum Neurobiol19827185792Yes
85825512551.050.850.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
85925512551.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SMITHIESBiochem J195513276348Yes
86025512551.0133.2133.2Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
86151002550.0133.366.7Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86225492549.083.583.5Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
86350982549.0143.671.8Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
86450962548.071.135.5Periodontal Disease In Pregnancy. I. Prevalence And Severity. H LOE, J SILNESSActa Odontol Scand196314121956Yes
86525482548.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
86625462546.0132.7132.7Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
86725442544.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FITTSJ Exp Psychol195413174710Yes
86850862543.0121.860.9Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
869126952539.0286.257.2Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
87050782539.0163.381.7Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rossello-MoraProc Natl Acad Sci U S A200919855009Yes
87150742537.0150.475.2Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
87250722536.0131.065.5Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
87325302530.063.263.2Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
87450462523.096.248.1CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
87525212521.061.261.2The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
87650392519.5135.167.5Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
87725192519.076.676.6Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
87825192519.044.044.0Wnt signaling and cancer. P PolakisGenes Dev200010921899No
87975572519.0298.399.4The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
88025162516.056.956.9Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
88150292514.5162.481.2Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
88225122512.044.544.5Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
88325102510.051.051.0Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
88425102510.070.170.1Hazards of heavy metal contamination. Lars JarupBr Med Bull200314757716No
88525072507.070.970.9Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
88625032503.062.862.8Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
88725022502.077.077.0Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
88824972497.060.260.2Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
88949942497.0119.659.8Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
89024962496.060.460.4The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
89124952495.052.652.6Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89224952495.052.152.1A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
89349852492.5180.990.5Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
89499422485.5212.053.0Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
89599382484.5196.749.2WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
89624842484.094.994.9Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
89749672483.593.446.7The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
89849642482.0105.552.8AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
89924802480.043.743.7Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
90074392479.7156.652.2The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
90149582479.0121.760.9Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
90224782478.079.679.6Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
90349542477.095.147.5Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
90424772477.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LENNOXVirology195513267987Yes
90524752475.0113.9113.9Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
90624742474.064.764.7Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
907197762472.0759.695.0The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver GlocknerNucleic Acids Res201323193283Yes
90824712471.062.962.9Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
90924712471.095.395.3Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
91024662466.028.128.1Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HIGUCHIJ Pharm Sci196314088963Yes
91124662466.058.858.8Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
91249322466.0138.369.2Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
91324652465.047.347.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
91473902463.3224.174.7Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
91524632463.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BERTANIJ Bacteriol195114888646Yes
91649172458.5106.453.2Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
91724582458.053.153.1Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
91824572457.063.063.0Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
91924562456.075.175.1Human error: models and management. J ReasonBMJ200010720363Yes
92024552455.057.957.9The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
92124532453.062.462.4The importance of selenium to human health. M P RaymanLancet200010963212No
92249032451.5171.685.8Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
92348992449.5112.756.4Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
92424482448.065.165.1Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
92524472447.053.853.8Social controls on cell survival and cell death. M C RaffNature19921557121No
92697772444.2455.0113.8The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
92724412441.067.767.7Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
92848782439.0109.254.6Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
92948682434.0175.287.6Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
93048622431.0126.763.4A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
93124272427.051.951.9Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
93224262426.049.149.1Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
93348462423.0135.167.5Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
93424232423.0128.9128.9The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
93524222422.055.955.9Specification of cerebral cortical areas. P RakicScience19883291116No
93648422421.097.248.6New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
93724202420.00.00.0Muscle structure and theories of contraction. A F HUXLEYProg Biophys Biophys Chem195713485191Yes
93824192419.048.648.6The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
93972522417.3257.885.9Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
94024172417.054.654.6A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
94148342417.0140.370.2Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
94224162416.074.974.9Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
94348312415.591.045.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassagueCell200312809600No
94424152415.080.580.5Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JobsisScience1977929199Yes
94548262413.0175.587.8The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
94624112411.062.862.8A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
94724102410.049.549.5NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
94872152405.0204.468.1The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
94948052402.5124.962.5Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
95048042402.0249.3124.7OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
95171902396.769.623.2On The Nature Of Allosteric Transitions: A Plausible Model. J MONOD, J WYMAN, J P CHANGEUXJ Mol Biol196514343300Yes
95223942394.056.156.1Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
95347862393.0119.159.5Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
95423932393.051.551.5Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
95547852392.5117.959.0Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
95623912391.0141.6141.6Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
95771732391.0209.869.9Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
95823882388.0104.2104.2International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
95971622387.3193.264.4Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
96047722386.0103.051.5Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
96147682384.096.648.3Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
96223832383.097.897.8The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
96395302382.5218.154.5Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
96447642382.089.244.6A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
96523712371.045.545.5The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
96623672367.091.791.7Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
96723662366.078.778.7A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
96823632363.042.842.8Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96947242362.0116.458.2The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
97047212360.5154.277.1Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
97147202360.0206.9103.5Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
97223572357.040.140.1Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
97323562356.067.167.1Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
97423552355.057.857.8A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
97547052352.577.538.8On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
97623512351.051.651.6The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
97747012350.5117.758.9The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
97894002350.0300.175.0Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
97923482348.068.768.7Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
98046952347.588.144.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
98146952347.5168.184.0mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
98223462346.052.652.6Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
98346912345.5111.155.5Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
98446892344.5192.596.2The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
98523432343.043.143.1Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
98623432343.072.272.2Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
98723422342.065.765.7Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
98823422342.062.462.4The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
98923372337.055.955.9The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
99046712335.5102.251.1Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
99146702335.077.038.5Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99246682334.0114.857.4A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
99323342334.048.648.6Theta oscillations in the hippocampus. Gyorgy BuzsakiNeuron200211832222No
99423322332.084.084.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
99569962332.0140.046.7EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
99623292329.069.669.6A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
99723282328.071.771.7Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
99823282328.057.057.0RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
99923272327.064.564.5Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
100046492324.5128.364.2Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
100123232323.085.985.9Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
100246452322.5164.482.2ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
100323212321.056.056.0Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
100423192319.078.778.7Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
100546372318.5128.164.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
100646312315.5190.995.5The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
100746292314.5145.973.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
100869372312.3263.687.9Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
100923122312.049.549.5A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
101046232311.5130.065.0Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
101146202310.089.044.5Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
101246162308.085.242.6SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
101323072307.061.261.2Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
101446102305.069.134.5High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
101546082304.0110.655.3Building better batteries. M Armand, J-M TarasconNature200818256660No
101646052302.5109.354.6Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
101723022302.056.556.5Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
101823012301.054.554.5Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
101923012301.047.647.6Complement. First of two parts. M J WalportN Engl J Med200111287977No
102022992299.092.192.1Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
102122982298.055.455.4Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
102222972297.067.167.1Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
1023252522295.6604.454.9PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
102422932293.069.369.3Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
102522932293.056.856.8What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
102622932293.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PENNESJ Appl Physiol194818887578Yes
102722922292.060.560.5Hybrid porous solids: past, present, future. Gerard FereyChem Soc Rev200818197340Yes
102845832291.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B SCOVILLE, B MILNERJ Neurol Neurosurg Psychiatry195713406589Yes
102922872287.063.763.7Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
103068562285.3156.752.2APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
103122852285.068.668.6Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
103222852285.056.556.5Descending control of pain. Mark J MillanProg Neurobiol200212034378No
103322842284.075.775.7Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
103422842284.045.145.1SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
103522832283.045.945.9Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
103622802280.074.474.4Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
103722792279.051.551.5Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
103822792279.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A CLAUSSActa Haematol195713434757Yes
103922752275.0112.2112.2Subjective well-being. E DienerPsychol Bull19846399758No
104045482274.086.843.4Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
104122712271.065.565.5Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
104245382269.0121.760.9Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
104345352267.589.244.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
104422652265.050.150.1Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
104522632263.053.053.0Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
104645192259.5121.560.8Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
104722592259.0138.4138.4Application of a microtechnique to viral serological investigations. J L SEVERJ Immunol196213910995Yes
104822582258.061.661.6Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
104922582258.048.248.2Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
105022562256.048.048.0Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
105145112255.5128.664.3Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
105222552255.080.180.1Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
105345082254.038.219.1A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
105467622254.0219.173.0Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
105545082254.0236.9118.5ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
105622512251.052.952.9Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
105722502250.057.657.6The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
105844992249.5102.251.1A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
105944992249.5102.651.3Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
106022482248.054.154.1Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gokhan S HotamisligilCell201020303879No
1061134842247.3296.649.4NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
106222472247.060.860.8Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
106322462246.095.895.8The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
106422462246.0116.0116.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
106522462246.076.776.7Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
106622462246.054.954.9Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
106722452245.048.748.7Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
106822452245.095.995.9Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
106944862243.0170.185.0Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
107067282242.7209.369.8Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris Sherman, Hepatology201121374666No
107144842242.0140.370.2A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
107244842242.094.147.0The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
107344792239.598.949.5The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
107422382238.048.748.7The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
107522372237.061.861.8phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
107622352235.065.665.6Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
107766982232.7181.260.4Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdottir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
107889232230.8343.585.9jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramon Doallo, David PosadaNat Methods201222847109Yes
107922282228.0110.5110.5Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
108022272227.052.152.1Mechanisms and genes of cellular suicide. H StellerScience19957878463No
108122272227.051.951.9Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
108244522226.097.949.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
108322262226.077.177.1International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
108444512225.594.647.3Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
108522252225.072.472.4A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
108622232223.039.639.6NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
108722202220.091.791.7A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
108822202220.059.559.5Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
108922202220.071.171.1Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
109044382219.0154.977.5ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
109144342217.084.042.0Network biology: understanding the cell's functional organization. Albert-Laszlo Barabasi, Zoltan N OltvaiNat Rev Genet200414735121No
109222162216.051.551.5Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
109322152215.049.049.0Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
1094177172214.6493.961.7The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
109544272213.5162.781.3Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
109622092209.067.467.4Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
109722092209.078.878.8Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
109844182209.0117.858.9EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
109922082208.069.369.3The Gingival Index, the Plaque Index and the Retention Index Systems. H LoeJ Periodontol19675237684Yes
110022062206.056.456.4Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
110122052205.082.882.8Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
110222042204.048.248.2Chemokines. B J RollinsBlood19979242519No
110344032201.594.147.0Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
110466022200.7119.039.7Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
110565952198.3166.555.5GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
110643932196.580.440.2The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
110765892196.3188.862.9Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
110821952195.052.152.1Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
110921942194.085.885.8Perception of risk. P SlovicScience19873563507Yes
111021942194.046.546.5Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
111121922192.066.966.9Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
111243832191.5147.073.5Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
111343832191.5163.881.9Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
111443792189.5171.885.9The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
111543782189.0185.292.6A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
111643752187.5132.866.4Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
111787462186.5202.150.5Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
111887392184.8282.670.7Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
111921832183.059.459.4Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
112021802180.058.758.7Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
112121782178.050.850.8Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
112243552177.5103.451.7Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
112343522176.099.549.8Neuronal oscillations in cortical networks. Gyorgy Buzsaki, Andreas DraguhnScience200415218136No
112443512175.582.641.3Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
112543492174.5189.794.8Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
112686972174.2205.251.3Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
112721732173.065.065.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
112843462173.094.747.4Liver fibrosis. Ramon Bataller, David A BrennerJ Clin Invest200515690074No
112921692169.049.849.8Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
1130108452169.0337.167.4The hallmarks of aging. Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
113121672167.040.740.7Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
113221672167.059.559.5Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
113321642164.041.441.4Protein modules and signalling networks. T PawsonNature19957531822No
113443252162.5124.062.0Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
113521622162.042.542.5Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
113621612161.049.549.5Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
113743202160.0101.150.5Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
113843132156.5104.452.2Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
113943132156.585.943.0'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
114021562156.042.742.7Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
114121562156.064.764.7Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
114221552155.00.00.0On respiratory impairment in cancer cells. O WARBURGScience195613351639Yes
114321542154.044.244.2Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
114421542154.065.965.9Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
114543072153.5106.653.3Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
1146150732153.3424.260.6AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
114721532153.030.630.6Sedimentation Studies Of The Size And Shape Of Dna. F W STUDIERJ Mol Biol196514290352Yes
114843012150.535.617.8Genetic regulatory mechanisms in the synthesis of proteins. F JACOB, J MONODJ Mol Biol196113718526Yes
114964492149.7205.768.6Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
115021492149.054.654.6Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
115142962148.0121.961.0Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
115221482148.050.750.7Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
115321482148.041.141.1DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
115421482148.080.480.4Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
115521472147.041.941.9Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
115621472147.041.141.1Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
115764392146.3129.143.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
115821462146.00.00.0A new specific color reaction of hexuronic acids. Z DISCHEJ Biol Chem194720281638Yes
115964372145.7145.848.6MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WuthrichJ Mol Graph19968744573Yes
116064342144.7204.568.2Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
116185772144.2317.179.3The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerstromBr J Addict19911932883Yes
116221442144.066.466.4The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
116342862143.0181.890.9The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
116442862143.071.435.7A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H VENABLE, R COGGESHALLJ Cell Biol196514287192Yes
116521402140.064.364.3The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
116664192139.7267.789.2Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
116742792139.5111.055.5The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
116821392139.044.744.7Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
116921372137.081.581.5Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
117021362136.065.965.9Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
117121352135.042.942.9Molecular bases for circadian clocks. J C DunlapCell19999988221No
117221322132.074.274.2Selenium and human health. Margaret P RaymanLancet201222381456No
117342632131.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F BEERS, I W SIZERJ Biol Chem195214938361Yes
1174149202131.4321.445.9Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
117542602130.0275.9137.9WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
117621302130.0182.2182.2Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Brent R StockwellCell202235803244No
117763892129.7205.968.6Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
117842572128.582.541.2Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
117942572128.5120.760.4Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
118042552127.5121.660.8Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
118142532126.5118.359.1Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
118221252125.044.144.1Mammalian G1 cyclins. C J SherrCell19938513492No
118342492124.589.945.0ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
118421232123.098.798.7Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
118542442122.0150.175.0Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
118621222122.083.383.3A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
118742432121.5152.776.3The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
118821212121.034.334.3Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AMINOFFBiochem J196113860975Yes
118942382119.082.441.2Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
119042372118.5142.671.3The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
119121172117.047.347.3The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
119242312115.5148.074.0The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
119342282114.0225.1112.5Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
119463412113.7182.260.7Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
119521122112.060.760.7The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
119621122112.049.349.3Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
119721122112.040.640.6DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
119842232111.5105.852.9Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
119921112111.047.247.2DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
120042192109.580.640.3The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
120163232107.7211.170.4Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
120221062106.047.447.4Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
120321012101.050.450.4Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
120421012101.080.980.9Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
1205147062100.9322.146.0Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
120684032100.8269.067.2Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
1207168062100.8393.549.2Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
120820992099.040.340.3Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
120920992099.00.00.0Cognitive maps in rats and men. E C TOLMANPsychol Rev194818870876Yes
121020992099.043.343.3The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
121141922096.0132.266.1Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
121241922096.0184.292.1Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
121341902095.0141.170.5The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683Yes
121441902095.0120.560.2LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
121520942094.039.539.5Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
121620932093.074.574.5Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
121720932093.056.656.6Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
121820932093.042.742.7TRP channels as cellular sensors. David E ClaphamNature200314654832No
121941852092.599.849.9Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
122020902090.052.552.5The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
122120892089.038.438.4Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
122220882088.052.052.0From sensation to cognition. M M MesulamBrain19989648540No
122320872087.065.865.8Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
122420862086.040.040.0Method For Assay Of Intestinal Disaccharidases. A DAHLQVISTAnal Biochem196414106916Yes
122520852085.064.964.9Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
122620852085.048.848.8Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
122720842084.057.457.4Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
122841662083.0101.450.7Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
122941622081.0127.363.6Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
123041602080.0110.755.4New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
123120802080.059.359.3ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
123220782078.038.938.9CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
123320752075.073.973.9AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
123420732073.063.263.2Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
123562172072.3198.166.0AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
123620722072.042.342.3G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
123720722072.036.436.4Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SKOUPhysiol Rev196514337569No
123841402070.089.244.6Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
123920692069.046.646.6The genetics of ageing. Cynthia J KenyonNature201020336132No
124020682068.051.851.8Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
124141332066.595.948.0Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
124241272063.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R DULBECCO, M VOGTJ Exp Med195413130792Yes
124320632063.057.557.5Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
124420632063.046.246.2Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
124582512062.8225.356.3Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
124641252062.585.642.8A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
124741232061.578.939.5A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelieresJ Microsc200617210054Yes
1248144292061.3381.554.5BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
124920612061.018.618.6The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W CLELANDBiochim Biophys Acta196314021667Yes
125020602060.047.447.4Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
125161802060.0253.384.4Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graca RaposoNat Rev Mol Cell Biol201829339798No
125261782059.3155.451.8Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
125361772059.0228.776.2Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
125420592059.053.153.1Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
125520572057.034.634.6ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
125620572057.0101.2101.2Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NEELAm J Hum Genet196213937884Yes
125741122056.0287.1143.6Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
125820552055.084.184.1A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
125920552055.067.667.6The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
126041102055.0110.155.0Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
126182182054.5368.592.1Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
126241082054.0125.462.7Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
126320532053.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A SHOLLJ Anat195313117757Yes
126420532053.023.823.8Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LITTLEFIELDScience196414168277Yes
126520522052.076.076.0α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
126641022051.0110.055.0Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
126720512051.055.755.7Introduction and General Overview of Cyclodextrin Chemistry. Jozsef SzejtliChem Rev199811848947Yes
126820492049.058.758.7Protein oxidation and aging. E R StadtmanScience19921355616No
126920492049.034.734.7Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
127040892044.590.045.0The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
1271183902043.3568.363.1The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
127240862043.0139.169.5Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
127320422042.063.363.3Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
127420412041.058.358.3Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
127540812040.5102.151.0Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
127640782039.092.246.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
127720382038.051.951.9Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
127820372037.060.060.0Social relationships and health. Sheldon CohenAm Psychol200415554821No
127940702035.0159.779.8Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
128020352035.051.951.9What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
128161042034.7265.988.6Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
128220332033.050.550.5Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
128340652032.597.748.9Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
128440642032.078.539.2An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
128540632031.599.249.6ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
128620312031.064.164.1Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
128740612030.5103.051.5Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
128820302030.084.084.0The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
128920282028.036.836.8In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
129020272027.050.650.6Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
129120272027.042.842.8A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
129281072026.8186.846.7Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
129320252025.047.047.0Calcium signaling. D E ClaphamCell19957834745No
129420252025.041.541.5The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
129540502025.091.545.8Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
129680992024.8269.567.4Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
1297141732024.7401.957.4The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, Lancet200718064739Yes
129840492024.5118.459.2The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
129920242024.038.938.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
130020242024.059.359.3Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
130120232023.051.451.4Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
130220232023.045.345.3The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
130320222022.088.688.6A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
130420222022.037.937.9Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
130540432021.598.249.1Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
130620212021.076.976.9Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
130720212021.039.739.7Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
130820202020.070.070.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
130940392019.5122.861.4Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
131040362018.0138.969.5The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
131160542018.0107.635.9Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
131220182018.052.152.1Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
1313121072017.8274.545.8GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
131420162016.059.459.4The inverse care law. J T HartLancet19714100731Yes
131540312015.585.342.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
131620152015.043.543.5Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
131720152015.052.752.7The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
131820142014.00.00.0Antigen-antibody reactions in gels. O OUCHTERLONYActa Pathol Microbiol Scand194918143039Yes
131940252012.5121.961.0Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
132040232011.586.643.3The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
132120112011.041.041.0XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
132220082008.043.243.2Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
132360222007.3172.457.5Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
132420072007.071.371.3The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
132520062006.043.643.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
132620052005.022.822.8A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
132720052005.034.634.6Signaling--2000 and beyond. T HunterCell200010647936No
132840102005.0111.255.6The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
1329120292004.8340.956.8New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
133020042004.054.854.8The biology of interleukin-6. T KishimotoBlood19892473791No
1331120162002.7340.656.8Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
133280022000.5309.077.2A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
1333100012000.2464.893.0ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
133439981999.094.147.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
133599941998.8225.445.1Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
133639971998.5112.156.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
133759921997.3296.598.8Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
133819961996.059.159.1The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
133919961996.075.575.5Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
134039911995.5106.753.4The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
134119941994.052.652.6Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
134239881994.0107.553.8Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
134319941994.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
134419931993.040.340.3Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
134539851992.5102.951.5Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
134619921992.043.743.7The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
134719921992.041.641.6Exploring complex networks. S H StrogatzNature200111258382No
134819911991.039.939.9Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
134919911991.051.151.1The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
135019901990.048.548.5Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
135139791989.589.544.8PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schuttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
135239781989.096.548.2Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
135319891989.051.351.3Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
135419871987.016.016.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
135539731986.559.729.9Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R MORRISON, L M SMITHJ Lipid Res196414221106Yes
135619861986.071.071.0Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
135739711985.5142.471.2Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
135819851985.052.052.0Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
135919851985.056.256.2Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
136039691984.5133.066.5Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
136159531984.3333.4111.1An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
136219831983.039.139.1The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
136319821982.046.146.1Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
136439611980.594.547.2The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
136519801980.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R STEELEAnn N Y Acad Sci195913833973Yes
136619791979.057.357.3Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
136739561978.086.643.3Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
136859311977.0194.864.9Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
136919771977.048.648.6High-speed scanning in human memory. S SternbergScience19665939936Yes
137039541977.077.538.8A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
137119771977.062.362.3The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
137239531976.579.940.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
137319751975.038.738.7Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
137439451972.5122.461.2Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
137539441972.073.636.8Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
137619721972.00.00.0On estimating the relation between blood group and disease. B WOOLFAnn Hum Genet195514388528Yes
137719711971.055.255.2The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
137819701970.063.663.6Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
137959101970.0148.549.5Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
138019691969.066.866.8Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
138119681968.057.657.6Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
138219681968.044.744.7The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
138319681968.042.542.5Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
138439331966.584.842.4Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
138539321966.0128.364.2Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
138619661966.076.476.4Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
1387157211965.1499.762.5GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, BMJ200818436948Yes
138858931964.3119.739.9Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
138919641964.055.455.4Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
139019631963.055.755.7Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
139178491962.2325.981.5An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
139278481962.0205.551.4Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
139319621962.058.058.0The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
139419611961.064.664.6Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
139519601960.054.454.4Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
139619601960.042.242.2Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
139719591959.057.457.4Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
139819581958.070.670.6Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
139919581958.040.440.4The etiology of chondromalacia patellae. R E OUTERBRIDGEJ Bone Joint Surg Br196114038135Yes
140039101955.0103.051.5Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
140139071953.587.643.8The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
140219531953.063.963.9The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
140319531953.041.041.0Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
140439051952.588.444.2Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
140519521952.062.062.0Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
140639041952.069.334.6Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
140739011950.565.532.8Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
140858511950.3345.1115.0Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
140919501950.045.645.6The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
141019491949.077.977.9Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
141119491949.077.477.4Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
141219481948.051.851.8Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141319471947.042.642.6Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
141419461946.045.745.7Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
1415136151945.0474.667.8Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
141619451945.053.653.6Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
141719451945.033.833.8The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
141819451945.055.555.5Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
141938881944.080.140.0Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
142038861943.0143.071.5A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
142158291943.0119.339.8Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
142219431943.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BOYDENJ Exp Med195114803635Yes
142358231941.0152.750.9Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RohlMol Biol Evol199910331250Yes
142419401940.056.156.1Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
142519381938.063.763.7Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
142619381938.068.168.1Antibiotics in the aquatic environment--a review--part I. Klaus KummererChemosphere200919185900No
142738761938.0102.551.2Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
142838761938.0125.662.8Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
142919371937.046.746.7Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
143038731936.5102.651.3Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
143119361936.076.876.8Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
143219351935.039.939.9The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
143319341934.051.151.1Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
143419331933.050.250.2DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
143519331933.041.441.4Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
143619321932.061.161.1Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
143738641932.0109.054.5How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
143838631931.5136.168.0Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
143938631931.5106.453.2CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
144057911930.3125.341.8Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
144177191929.8187.246.8p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
144219271927.046.746.7Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
1443250201924.6932.371.7Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, Genet Med201525741868Yes
144438461923.0191.095.5Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
144538431921.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J VOGEL, D M BONNERJ Biol Chem195613278318Yes
144619211921.039.739.7A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
144719211921.091.491.4DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
144857591919.7169.756.6Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
144938381919.0127.663.8Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
145019191919.046.746.7DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
145195901918.0417.583.5Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L SalzbergNat Biotechnol201931375807Yes
145219171917.051.651.6Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
145357491916.3117.139.0A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
145438321916.087.843.9Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
145519141914.042.742.7Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
145638271913.588.644.3Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
145719131913.050.550.5Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
145819131913.050.150.1Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
145919101910.051.351.3A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
146019101910.043.643.6Tricine-SDS-PAGE. Hermann SchaggerNat Protoc200617406207Yes
146176371909.2212.553.1The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
146219091909.053.553.5In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
146319091909.076.876.8Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
146438181909.084.842.4Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
146557241908.0337.8112.6Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
146619061906.041.041.0The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
146738101905.0114.257.1Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
146838071903.5122.261.1miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
146919031903.037.537.5Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
147038041902.0100.050.0Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
147119011901.087.687.6A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
147219011901.034.234.2Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
147319011901.050.250.2The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
147419001900.00.00.0The oxidation of ribonuclease with performic acid. C H HIRSJ Biol Chem195613319283Yes
147518981898.019.819.8Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
147637941897.089.244.6The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
147718971897.037.437.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
147818971897.037.537.5Points of control in inflammation. Carl NathanNature200212490957No
147956861895.3124.941.6A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
148018951895.064.664.6The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
148118951895.092.392.3Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. Cynthia RudinNat Mach Intell201935603010Yes
148218941894.042.642.6The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
148375721893.0251.562.9Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
148418931893.058.858.8The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
148537831891.5112.256.1An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
148694561891.2213.642.7Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
148718911891.046.546.5The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
148818901890.082.782.7Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
148918891889.060.860.8Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
149018891889.064.564.5The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
149118891889.036.636.6Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
149218891889.057.257.2The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
149337771888.577.638.8Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
149418881888.044.744.7Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
149518881888.033.833.8Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
149618861886.0125.8125.8The changing landscape of atherosclerosis. Peter LibbyNature202133883728No
149737711885.585.342.6The Fas death factor. S Nagata, P GolsteinScience19957533326No
149818841884.086.086.0Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
149918841884.043.643.6The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
150056521884.0157.752.6Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallieres, C M. MorinSleep Med200111438246Yes
150137671883.576.638.3Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
150218821882.033.733.7Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
150318821882.036.236.2MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
150418811881.053.853.8An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
150518811881.035.035.0Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
150618811881.047.647.6Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
150718811881.039.039.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
150837601880.0190.495.2Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
150937601880.0100.550.2Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
151093991879.8329.866.0UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
151118791879.099.199.1Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
151256321877.3139.346.4Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
151375081877.0179.044.8Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
151437531876.586.743.4Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
151518751875.035.935.9The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
151637491874.577.638.8Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
151737461873.0134.067.0Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
151818731873.070.670.6Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
151937461873.075.137.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
152037451872.5105.152.5Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
152118711871.042.442.4Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
152218711871.054.554.5Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
152318711871.053.653.6A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
152418711871.042.142.1The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
152537421871.084.242.1Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
152637411870.5120.460.2Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
152718701870.046.146.1Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
152818691869.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
152956051868.3143.847.9A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
153018681868.048.448.4Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
153118671867.057.757.7Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
153218661866.042.542.5Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
153374641866.0279.870.0QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
153418641864.043.043.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
153518641864.044.544.5Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
153618641864.066.366.3Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
153718641864.055.255.2Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
153818641864.037.737.7Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
1539148991862.4415.852.0Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
154037211860.5143.271.6Assays of glutathione peroxidase. L Flohe, W A GunzlerMethods Enzymol19846727659Yes
154118601860.017.917.9A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A ROBINSONIEEE Trans Biomed Eng196314121113Yes
154218591859.045.745.7Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
154318591859.080.880.8Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
154437171858.577.538.8Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
1545111511858.5296.949.5A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
154618581858.052.152.1Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
154755741858.0102.834.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
154818561856.050.250.2Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
154918561856.043.743.7Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
155018551855.055.355.3Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
155137081854.0133.866.9The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
155255621854.0377.2125.7Ferroptosis: mechanisms, biology and role in disease. Xuejun Jiang, Brent R Stockwell, Marcus ConradNat Rev Mol Cell Biol202133495651No
155318531853.041.141.1DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
155418521852.044.344.3Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
155537031851.5114.157.0Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
155637011850.596.148.0The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
155737011850.595.147.5A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
155874011850.2340.285.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
155918501850.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SIMPSONJ Neurol Neurosurg Psychiatry195713406590Yes
156018491849.067.667.6Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
156118491849.043.143.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
156218481848.036.536.5Protein homology detection by HMM-HMM comparison. Johannes SodingBioinformatics200515531603Yes
156392371847.4235.547.1Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
156418461846.062.862.8Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
156573821845.5209.952.5Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
156636901845.0117.658.8Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156755321844.0120.740.2Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
156836881844.052.926.4Immunoassay of insulin with insulin-antibody precipitate. C N HALES, P J RANDLEBiochem J196313952078Yes
156955301843.3169.856.6SCANPY: large-scale single-cell gene expression data analysis. F Alexander Wolf, Philipp Angerer, Fabian J TheisGenome Biol201829409532Yes
157018431843.050.550.5Protein denaturation. C TanfordAdv Protein Chem19684882248No
157118431843.041.941.9Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
157218431843.034.334.3Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
157318421842.060.160.1Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
157418421842.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SKOUBiochim Biophys Acta195713412736Yes
157518411841.047.047.0Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
157618411841.040.840.8A revolution in optical manipulation. David G GrierNature200312917694No
157718401840.054.554.5Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
157836801840.0106.953.5The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
157918401840.065.565.5Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
158055171839.0141.147.0The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
158136781839.092.846.4Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
158273561839.0139.034.8Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
158318381838.067.467.4Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
158418361836.059.459.4The crisis in antibiotic resistance. H C NeuScience19921509257No
158518351835.041.441.4PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
158636691834.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T CAMPBELL, D W FISKEPsychol Bull195913634291Yes
158718341834.048.648.6New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
158818341834.038.338.3Perceptions of epigenetics. Adrian BirdNature200717522671Yes
158918331833.042.742.7Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
159036661833.0128.564.2Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
159191631832.696.819.4Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFEJAMA196314044222Yes
159254971832.3118.639.5A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
159336621831.090.345.1Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
159436621831.0104.852.4Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
159591511830.2219.043.8Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
159636591829.574.837.4Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
159718281828.065.065.0A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
159836551827.5106.653.3An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
159918261826.050.150.1Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
160018261826.037.737.7Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
160136501825.0135.267.6The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
160218251825.0102.0102.0A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
160391201824.0330.866.2Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. J B Saunders, O G Aasland, T F Babor, J R de la Fuente, M GrantAddiction19938329970Yes
160418241824.036.436.4Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
160518241824.075.775.7Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
160618231823.089.089.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S COHENJ Biol Chem196213880319Yes
160718231823.037.437.4Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
160872761819.0279.469.816S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
160918181818.062.962.9A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
161036331816.580.340.1The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
161118161816.043.143.1The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
161236291814.5101.951.0Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
161354411813.7174.958.3A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
161418131813.00.00.0A new readability yardstick. R FLESCHJ Appl Psychol194818867058Yes
161518131813.019.019.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
1616181251812.5564.456.4Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
1617199361812.4492.644.8The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
161818111811.059.059.0Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
161936201810.0206.9103.5An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
162018091809.043.643.6Why genes in pieces? W GilbertNature1978622185Yes
162118081808.035.835.8Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
162218071807.039.039.0The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
162336141807.0137.468.7MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
162436101805.086.143.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
162518021802.064.264.2Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
162672081802.0249.862.5FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
162772051801.2309.677.4A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
162818011801.058.258.2Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
162918011801.076.076.0Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
163018011801.046.046.0Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
163118001800.00.00.0The measurement of volume changes in human limbs. R J WHITNEYJ Physiol195313085295Yes
163218001800.065.065.0Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
163335991799.588.844.4The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
163417991799.097.797.7Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
163517991799.057.357.3Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
163617991799.037.637.6An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
163735971798.591.145.5Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
163817981798.037.737.7AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
163917981798.038.438.4Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
164089861797.2363.672.7BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
164135911795.574.237.1Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
164217951795.046.946.9THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
164317951795.042.842.8External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
164435891794.569.134.5The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
164571781794.5227.156.8cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Ali Punjani, John L Rubinstein, David J Fleet, Marcus A BrubakerNat Methods201728165473Yes
164617941794.040.940.9Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
164735871793.5161.580.8Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
164817931793.047.447.4Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
164917911791.053.153.1Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
165017911791.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HESTRINJ Biol Chem194918133390Yes
165135811790.5117.158.5Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
165217901790.054.454.4Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
165317901790.021.421.4Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
165435801790.0110.455.2Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
165517901790.0199.0199.0Epidemiology of chronic kidney disease: an update 2022. Csaba P KovesdyKidney Int Suppl (2011)202235529086No
165617891789.063.763.7Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287Yes
165717881788.059.059.0Serum albumin. T PetersAdv Protein Chem19853904348No
165817881788.047.147.1Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
165917881788.055.355.3Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
166035751787.5152.676.3A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
166135741787.086.343.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
166235741787.0100.250.1Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
166317861786.065.965.9Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
166417861786.077.977.9The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
166535721786.0140.670.3Interpreting findings from Mendelian randomization using the MR-Egger method. Stephen Burgess, Simon G ThompsonEur J Epidemiol201728527048Yes
166617851785.050.850.8Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
166717821782.041.341.3Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
166835631781.586.443.2Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
166935611780.589.444.7Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
167017801780.035.835.8An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
167117801780.067.567.5Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
167217781778.049.549.5Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
167353341778.0123.541.2Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck OrntoftCancer Res200415289330Yes
167417781778.091.791.7Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
167517771777.058.758.7Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
167617771777.038.238.2Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
167753311777.0118.939.6Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
167835531776.580.640.3Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
167917761776.064.364.3Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
168017761776.059.359.3The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
168117761776.039.139.1Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
168235511775.5146.873.4Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
168317751775.046.346.3Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
168453251775.0114.838.3An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
168535491774.580.940.5Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
168688711774.2307.761.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, J Clin Epidemiol200919631508No
168717741774.046.446.4Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
168817741774.033.233.2Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
168935481774.080.240.1Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
1690212861773.8630.852.6A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, Ann Intern Med200919414839Yes
169117731773.038.338.3Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
169235461773.088.244.1Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
169317731773.053.453.4Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
169435451772.572.736.4Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
169517721772.033.833.8Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
169653141771.3163.354.4Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
169717711771.058.458.4Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
169835401770.0164.182.0Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
169917691769.040.440.4Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
170017681768.033.733.7The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
170117681768.036.536.5The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
170235351767.5150.275.1A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
170335351767.543.921.9A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
170470691767.2212.653.1The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
1705106031767.2212.535.4Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
170617661766.079.579.5ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
170717651765.040.140.1Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
170835291764.5225.9113.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
170917641764.047.247.2G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
171017641764.041.741.7Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
171117631763.060.360.3The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
171217631763.038.838.8ATPase activity of myosin correlated with speed of muscle shortening. M BaranyJ Gen Physiol19674227924Yes
171317631763.017.717.7The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
171417631763.059.059.0Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
171517631763.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
171635251762.593.146.5Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
171717611761.040.140.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
171817611761.048.748.7The in vitro micronucleus technique. M FenechMutat Res200011113469No
171917611761.074.474.4When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
172035201760.084.942.5Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
172135201760.0357.9178.9Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Luke A McGuinness, Julian P T HigginsRes Synth Methods202132336025Yes
1722158271758.6479.153.2The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
172317571757.038.338.3The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SudhofNature19957791897No
172417571757.00.00.0A personality scale of manifest anxiety. J A TAYLORJ Abnorm Psychol195313052352Yes
172517561756.044.344.3The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
172617551755.054.054.0Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
172735091754.5111.455.7The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
172852621754.0111.737.2Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
172917541754.038.738.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
173035051752.5129.364.7Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
173135051752.596.948.5Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
173217521752.041.941.9Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
173335031751.593.446.7Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
173417511751.040.840.8Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
173517511751.074.174.1Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
173617511751.059.559.5Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
173717511751.038.738.7Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
173835021751.069.034.5Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
173935021751.071.335.6The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
174017511751.070.370.3Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
174152521750.7121.340.4Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
174235001750.0221.9111.0A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
174317501750.060.260.2The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
174470001750.0136.134.0Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
174517491749.00.00.0Notes on continuous stochastic phenomena. P A P MORANBiometrika195015420245Yes
174617481748.038.338.3In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
174717481748.0148.8148.8COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
174817471747.039.239.2Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
174917471747.031.831.8Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
175034941747.083.841.9Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
175134941747.097.248.6Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
175234941747.0128.664.33D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
175334921746.075.437.7Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
175417451745.068.768.7A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
175517451745.045.745.7A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
175634881744.086.143.0Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
175717441744.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RANKINScott Med J195713432835Yes
175834871743.592.246.1Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
1759104601743.3286.847.8Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
176017431743.074.774.7Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
1761174251742.5549.955.0The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
176217421742.062.262.2Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
176334831741.5133.066.5Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
176434821741.071.936.0A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FluggeAnal Biochem19846731838Yes
176552201740.0271.690.5Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
176617401740.047.547.5The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
176734791739.585.943.0The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
176834781739.082.141.0CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
176917381738.050.750.7Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
177017361736.055.955.9Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
177186801736.0307.161.4Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
177217351735.062.162.1Cyclosporine. B D KahanN Engl J Med19892687689No
177317351735.069.269.2Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
177417351735.00.00.0The general adaptation syndrome and the diseases of adaptation. H SELYEJ Clin Endocrinol Metab194621025115Yes
177534691734.589.744.9Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
177652031734.3202.667.5The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
177717341734.031.431.4Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
177834671733.594.947.5Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
177917311731.052.352.3A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
178034611730.570.035.0The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
178151911730.3111.437.1Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
178217301730.030.830.8Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
178317291729.031.431.4How eukaryotic transcriptional activators work. M PtashneNature19883050531No
178417291729.035.835.8Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
178569131728.2215.253.8SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Soren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
178617281728.056.156.1Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
178717281728.054.854.8A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
178834541727.071.735.9Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
178917271727.033.433.4DNA in a material world. Nadrian C SeemanNature200312540916No
179017261726.065.965.9Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
179186281725.6294.558.9Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
179217231723.044.344.3Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
179317231723.048.248.2The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
179434461723.066.033.0The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
179517221722.051.651.6The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
179651641721.3230.276.7Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
179717201720.072.972.9The micronucleus test. W SchmidMutat Res197548190Yes
179834391719.573.136.5Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
179917191719.064.864.8Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
180017191719.070.870.8The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
180134371718.577.939.0Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
180234361718.0197.598.8Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
180368711717.8140.635.1Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
180417171717.051.951.9Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
180517171717.044.244.2Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
180617171717.069.869.8PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
180717161716.041.941.9The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
1808120091715.6376.353.8The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, J Clin Epidemiol200818313558Yes
180934301715.084.042.0EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
181085711714.2365.573.1CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
181117141714.055.555.5Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
181217141714.045.445.4Surface plasmon resonance sensors for detection of chemical and biological species. Jiri HomolaChem Rev200818229953No
181317131713.00.00.0Cerebral blood flow and oxygen consumption in man. N A LASSENPhysiol Rev195913645234Yes
181451381712.7130.743.6Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
181517111711.045.645.6Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
181634211710.595.547.8Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
181734201710.080.640.3The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
181834201710.0104.052.0Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
181917101710.038.038.0Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
182017081708.044.244.2BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
182134151707.570.035.0Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
182217071707.035.335.3Neuronal calcium signaling. M J BerridgeNeuron19989697848No
182334141707.049.724.9A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J KARNOVSKY, L ROOTSJ Histochem Cytochem196414187330Yes
182417061706.035.535.5Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
182517051705.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
182617051705.070.270.2The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
182734081704.0113.056.5Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
182817041704.037.737.7Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
182934081704.080.040.0Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
183034071703.571.435.7The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
183117031703.083.783.7Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerstromAddict Behav1978735910Yes
183217031703.042.842.8The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
183317031703.055.355.3Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
183451091703.097.132.4T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
183534061703.070.935.5Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
183617031703.062.662.6MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
183717011701.033.033.0Hox genes in vertebrate development. R KrumlaufCell19947913880No
183817011701.041.341.3Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
183934001700.066.533.2Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
184016991699.031.131.1Switching and signaling at the telomere. E H BlackburnCell200111572773No
184116991699.037.437.4Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
184233961698.0121.760.9The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
184316971697.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GRAYJ Anat195913829103Yes
184416971697.038.438.4The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
184533921696.078.939.5The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
184633911695.5110.655.3Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
184733911695.593.046.5Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
1848101711695.2231.438.6Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
184916951695.040.140.1A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
185016951695.038.238.2NADPH oxidase: an update. B M BabiorBlood199910029572No
185133891694.591.645.8Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
185216941694.040.140.1The molecular genetics of cancer. J M BishopScience19873541204No
185316941694.022.622.6RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
185416941694.047.247.2Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
185533871693.5127.663.8A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
185616931693.049.049.0Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
185716931693.083.283.2Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
185816931693.031.931.9Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
185916931693.033.633.6Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
186067721693.0286.971.7NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
186133831691.5127.563.8The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
186216911691.044.844.8Integrins. E RuoslahtiJ Clin Invest19911985087No
186316911691.048.548.5The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
186416911691.041.741.7Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
186516911691.029.129.1Plastic Embedding Mixtures For Use In Electron Microscopy. H H MOLLENHAUERStain Technol196414127791Yes
186616911691.044.944.9Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
186716911691.054.054.0PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
186816911691.061.361.3Inflammation, metaflammation and immunometabolic disorders. Gokhan S HotamisligilNature201728179656No
186933811690.574.937.5Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
187033801690.095.047.5The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
187133801690.0118.259.1Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
187250681689.3109.436.5Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
187316881688.052.952.9Metallothionein. D H HamerAnnu Rev Biochem19863527054No
187416881688.058.758.7Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
187516881688.042.942.9Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
187633731686.598.749.4Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
187716861686.043.343.3Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
187816861686.032.532.5Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
187933711685.564.232.1NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
1880101131685.5227.838.0Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O LotvallNat Cell Biol200717486113Yes
188116851685.073.573.5Mood and memory. G H BowerAm Psychol19817224324Yes
188216841684.029.829.8CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
188333681684.072.636.3The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
188416821682.038.138.1The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
1885100891681.5348.058.0Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
188616801680.043.143.1Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
188716801680.014.014.0Chromatographic Separation Of Human Brain Gangliosides. L SVENNERHOLMJ Neurochem196314066623Yes
188816801680.036.736.7Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
188916791679.033.833.8Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
1890100731678.8321.353.6Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
189116771677.058.258.2Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
189216771677.032.032.0Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
189316771677.049.449.4Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
189416771677.039.439.4Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
189516761676.063.363.3Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
189616751675.040.340.3Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
189716751675.045.145.1Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
189816731673.084.784.7Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
189933451672.5190.995.5Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Helmut Sies, Dean P JonesNat Rev Mol Cell Biol202032231263No
190050171672.3134.844.9Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
190150161672.0137.645.9Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
190216721672.049.849.8Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
190316711671.058.858.8Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
190466771669.2155.738.9Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
190516691669.037.437.4A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
190616691669.00.00.0Method for the determination of hexosamines in tissues. N F BOASJ Biol Chem195313117829Yes
190716681668.052.052.0Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
190816681668.047.247.2Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
190933361668.0106.753.4Mendelian randomization: genetic anchors for causal inference in epidemiological studies. George Davey Smith, Gibran HemaniHum Mol Genet201425064373No
191033351667.580.940.5Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
191116671667.063.563.5A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
191233331666.585.842.9Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
191333331666.5105.352.6How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
191416661666.041.641.6Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
191533321666.054.427.2The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T OMURA, R SATOJ Biol Chem196414209972Yes
191633301665.094.147.0Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
191716651665.039.339.3Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
191849941664.7104.534.8Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
191949931664.3125.241.7Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
192033261663.060.330.1Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
192116631663.064.864.8An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
192216631663.039.239.2Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
192333261663.092.746.4What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
192416631663.034.834.8Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
192516631663.051.551.5Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
192616621662.031.531.5Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
192733231661.597.148.5Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
192816611661.049.049.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
192916611661.047.047.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
193066421660.5256.364.1Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Jack Bowden, George Davey Smith, Philip C Haycock, Stephen BurgessGenet Epidemiol201627061298Yes
193116601660.056.856.8Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
193249791659.7118.939.6Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
193366371659.2151.737.9Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
193416591659.076.376.3Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
193516591659.036.236.2Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323Yes
193616591659.037.537.5Upconversion and anti-Stokes processes with f and d ions in solids. Francois AuzelChem Rev200414719973Yes
193716591659.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KETYPharmacol Rev195114833874Yes
193833171658.571.335.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
193933171658.569.234.6Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
194049741658.0163.454.5CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
194133151657.583.141.5Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
194216571657.053.353.3Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
194316571657.031.331.3The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
194416561656.050.350.3The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
194533111655.567.333.6Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassagueCell200617110329No
194649661655.3179.059.7Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
194716551655.036.736.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
194816531653.050.250.2The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
194916531653.030.230.2Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
195033061653.074.237.1Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
195116521652.041.441.4Aspergillus fumigatus and aspergillosis. J P LatgeClin Microbiol Rev199910194462No
195216521652.022.522.5Structural considerations in the interaction of DNA and acridines. L S LERMANJ Mol Biol196113761054Yes
195366081652.0213.153.3Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior PachterNat Biotechnol201627043002Yes
195416511651.039.339.3Fast and robust fixed-point algorithms for independent component analysis. A HyvarinenIEEE Trans Neural Netw199918252563Yes
195516501650.039.439.4The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
195633001650.071.535.8NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195733001650.065.732.9Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
195816501650.029.829.8Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
195916501650.043.943.9Bioactive microbial metabolites. Janos BerdyJ Antibiot (Tokyo)200515813176No
196049491649.7125.241.7How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
196132981649.092.946.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
196232971648.559.029.5The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
196316471647.033.233.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
196416471647.048.348.3Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
196532941647.092.946.5Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
196632931646.596.848.4Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
196716461646.056.656.6Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
196816461646.045.045.0Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
196916461646.034.834.8Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
197016461646.061.061.01,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
197132911645.577.638.8Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
197216451645.047.047.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
197316451645.027.527.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
1974131571644.6308.638.6Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, N Engl J Med200211832527Yes
197516441644.072.072.0The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
197616441644.043.043.0n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
197716431643.031.531.5The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
197849271642.3267.589.2MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
197916421642.034.434.4From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
198016421642.028.528.5Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
198116421642.037.837.8Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
198232821641.094.347.1An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
198349211640.393.731.2The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jurg TschoppMol Cell200212191486Yes
198432791639.574.837.4A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
198532791639.565.832.9Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
198616391639.044.944.9Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
198716391639.036.936.9The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
198832771638.5178.689.3Osteoarthritis. David J Hunter, Sita Bierma-ZeinstraLancet201931034380No
198916381638.070.970.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
199016381638.030.330.3Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
199116381638.030.330.3Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
199281901638.0293.358.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Int J Surg201020171303No
199316371637.051.051.0Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
199416361636.028.628.6Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
199516361636.051.351.3Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
199616361636.030.030.0Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
199716361636.043.543.5Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
199832721636.078.139.0Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
199916351635.042.542.5Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
200081741634.8282.256.4Salmon provides fast and bias-aware quantification of transcript expression. Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl KingsfordNat Methods201728263959Yes
200116341634.0112.3112.3Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
200216341634.0103.9103.9A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MATTINGLYJ Clin Pathol196214471419Yes
200332671633.596.348.1Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E Barlow, Pediatrics200718055651Yes
200432661633.065.732.9Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
200516331633.068.168.1Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
200632651632.581.540.8Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
200732641632.076.538.2Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
200816321632.029.429.4Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
200948961632.054.118.0Improved method for the determination of blood glutathione. E BEUTLER, O DURON, B M KELLYJ Lab Clin Med196313967893Yes
201032641632.063.831.9Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
201116311631.034.634.6Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
201232611630.5192.196.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
201332611630.5179.789.8Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J MARMUR, P DOTYJ Mol Biol196214470099Yes
201416301630.035.735.7Thiazolidinediones. Hannele Yki-JarvinenN Engl J Med200415356308No
201565201630.0213.753.4The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
201648891629.7136.145.4The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
2017114041629.1268.738.4Integrative genomics viewer. James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
201816291629.058.058.0Cell damage in the brain: a speculative synthesis. B K SiesjoJ Cereb Blood Flow Metab19816276420No
201916291629.029.929.9Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
202032581629.066.933.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
202132571628.578.239.1Obesity. David W Haslam, W Philip T JamesLancet200516198769No
202216281628.045.745.7Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
202316281628.051.151.1SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
202416271627.051.051.0The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
202516261626.052.252.2Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
202616261626.071.671.6Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
202716261626.056.256.2Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
202816241624.046.246.2The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinasScience19883059497No
202932471623.560.530.2Mutations affecting segment number and polarity in Drosophila. C Nusslein-Volhard, E WieschausNature19806776413Yes
203016231623.040.540.5Molecular biology of prion diseases. S B PrusinerScience19911675487No
203116221622.047.347.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
203232441622.062.331.1Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
203316211621.051.651.6Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
203416211621.063.563.5Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
203516211621.026.226.2Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
203616201620.00.00.0Discharge patterns and functional organization of mammalian retina. S W KUFFLERJ Neurophysiol195313035466Yes
203716201620.054.954.9Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
203864791619.8284.871.2Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron DoNat Genet201829686387Yes
203932381619.078.839.4Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
204016181618.034.234.2On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
204132361618.079.839.9A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
204232351617.577.138.5Dali server: conservation mapping in 3D. Liisa Holm, Paivi RosenstromNucleic Acids Res201020457744Yes
204348521617.3115.238.4Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
204416171617.042.042.0Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
204516171617.033.533.5The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
204616171617.029.329.3How cells read TGF-beta signals. J MassagueNat Rev Mol Cell Biol200011252892No
204732341617.077.939.0Abdominal obesity and metabolic syndrome. Jean-Pierre Despres, Isabelle LemieuxNature200617167477No
204816171617.00.00.0The generalisation of student's problems when several different population variances are involved. B L WELCHBiometrika194720287819Yes
204932331616.5238.7119.3Gut microbiota in human metabolic health and disease. Yong Fan, Oluf PedersenNat Rev Microbiol202132887946No
205016161616.032.732.7Drug discovery: a historical perspective. J DrewsScience200010720314No
205116161616.031.631.6RNA silencing in plants. David BaulcombeNature200415372043No
205232321616.076.938.5Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
205332311615.5102.151.0Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
205416141614.028.928.9Altering the genome by homologous recombination. M R CapecchiScience19892660260No
205532271613.557.328.6Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
205648401613.3117.539.2Management of hepatocellular carcinoma. Jordi Bruix, Morris Sherman, Hepatology200516250051No
205764531613.2149.537.4CHARMM-GUI: a web-based graphical user interface for CHARMM. Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil ImJ Comput Chem200818351591No
205816121612.039.939.9The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
205916121612.033.033.0Sustainable hydrogen production. John A TurnerScience200415310892Yes
206016121612.045.245.2Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
206132221611.0110.255.1Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
206248331611.088.529.5Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
206316111611.033.133.1DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
206432221611.0105.352.6A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
206516101610.019.419.4Dithiothreitol, A New Protective Reagent For Sh Groups. W W CLELANDBiochemistry196414192894Yes
206632181609.088.144.0Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
206716091609.049.349.3Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
206816091609.034.134.1Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
2069160891608.9374.937.5Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
207032161608.063.031.5The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
207132161608.0150.075.0Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
207216071607.036.436.4Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
207316071607.034.234.2Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
207432131606.591.445.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
207532121606.082.341.1Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
207616061606.046.646.6The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
207732111605.5113.156.5Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
207816051605.029.329.3The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
207916051605.049.749.7The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
208032101605.060.930.4Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
208148151605.0115.438.5The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
208216051605.045.645.6The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
208316051605.047.947.9Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
208448131604.394.131.4Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
208516041604.035.335.3Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
2086128321604.0311.238.9Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
208716031603.039.639.6Tumor necrosis factor (TNF). L J OldScience19852413547Yes
208816031603.044.544.5Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
208916031603.051.851.8The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FrohlichInt J Nanomedicine201223144561No
209032051602.567.033.5Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
209148061602.0152.951.0Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graca Raposo, Clotilde TheryAnnu Rev Cell Dev Biol201425288114No
209280071601.4153.230.6Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
209316011601.081.481.4The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
209416011601.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OUCHTERLONYActa Pathol Microbiol Scand195313079779Yes
209596021600.3273.445.6TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
209616001600.036.536.5VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
209715991599.031.331.3An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
209831981599.077.438.7A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
209963931598.2150.337.6Universal sample preparation method for proteome analysis. Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
210031961598.099.249.6The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
210115981598.058.158.1What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhaSoc Sci Med200919520474Yes
210247931597.7120.340.1I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
210363901597.5260.965.2Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
210495771596.2282.947.1The Molecular Signatures Database (MSigDB) hallmark gene set collection. Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo TamayoCell Syst201526771021Yes
210531921596.072.336.1Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
210615961596.033.233.2Far-field optical nanoscopy. Stefan W HellScience200717525330No
210715951595.048.048.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
210863771594.2155.138.8Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
210931881594.060.230.1Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
211015931593.056.156.1Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
211115921592.050.150.1The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
211215921592.039.539.5Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
211315921592.00.00.0Nutrition needs of mammalian cells in tissue culture. H EAGLEScience195513255879Yes
211431831591.561.630.8Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
211515901590.037.637.6HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
211615901590.042.742.7The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
211731801590.063.131.6Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
2118206611589.3515.639.7Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
211931781589.096.148.0Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
212047631587.792.130.7Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
212115871587.046.946.9Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
212215861586.041.141.1Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
212315861586.035.135.1The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
212431721586.096.148.0Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
212547551585.0157.252.4Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
212615851585.031.431.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
212715851585.075.575.5Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
212815821582.078.678.6Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
212915821582.037.337.3Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
213031631581.5100.650.3The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
213131621581.066.133.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
213215811581.052.852.8The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
213315811581.058.958.9Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
213415801580.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HUMMELCan J Biochem Physiol195914405350Yes
213515801580.053.753.7Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
213615791579.052.552.5Biology of interleukin 1. C A DinarelloFASEB J19883277884No
213715791579.033.133.1Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
213863141578.5180.545.1Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
213915781578.044.944.9Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
214015781578.046.946.9Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
214115781578.045.045.0Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
214215781578.040.640.6Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
214315771577.064.464.4Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
214447311577.0141.747.2Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
214563041576.0119.029.8A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
214631511575.589.344.6Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
214715751575.042.542.5Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
214831491574.587.243.6A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marcais, Carl KingsfordBioinformatics201121217122Yes
214931481574.097.648.8Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
2150110121573.1356.050.9Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
215115731573.058.958.9Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
215215731573.038.638.6Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
215315731573.041.041.0Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
215415721572.049.249.2ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Tristan Ian CrollActa Crystallogr D Struct Biol201829872003Yes
215531411570.560.730.4Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
215631411570.5117.858.9Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958Yes
215731401570.021.710.8Junctional complexes in various epithelia. M G FARQUHAR, G E PALADEJ Cell Biol196313944428Yes
215815691569.043.743.7The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
215962741568.5312.678.2Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E HoltPLoS Comput Biol201728594827Yes
216015681568.049.249.2Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
216115681568.041.541.5The pollution of the marine environment by plastic debris: a review. Jose G B DerraikMar Pollut Bull200212405208No
216231361568.0112.356.1Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
216331351567.568.134.0Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
216415671567.057.157.1Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
216515671567.033.233.2The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
216631331566.579.839.9Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
216746981566.0128.042.7The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
216815661566.033.833.8Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
216915661566.031.331.3Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
217031301565.0100.650.3Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
217115641564.059.959.9Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217246921564.0128.342.8Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
217346911563.7110.937.0Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
217415631563.036.436.4Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
217515631563.046.546.5Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
217631251562.538.619.3Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
217715611561.068.868.8Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
217815611561.029.529.5A New Weighting System For Mean Surface Temperature Of The Human Body. N L RAMANATHANJ Appl Physiol196414173555Yes
217915601560.028.028.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
218015601560.042.542.5Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
218115601560.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
218215601560.031.931.9Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
218315591559.053.053.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
218415591559.032.632.6Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
218546741558.0110.736.9Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
218615581558.046.346.3The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
2187108941556.3227.332.5Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
218846691556.3161.153.7Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
218946651555.0156.452.1Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
219015551555.050.750.7Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
219115551555.039.639.6Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
219246621554.0102.834.3Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
219331071553.589.144.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
219415531553.043.843.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
219515531553.038.638.6Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
219615521552.091.691.6Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
219715521552.055.155.1Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
219815511551.043.143.1Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
219915511551.034.034.0Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
220015501550.034.834.8Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
220130991549.588.544.2A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
220230991549.597.848.9MissForest--non-parametric missing value imputation for mixed-type data. Daniel J Stekhoven, Peter BuhlmannBioinformatics201222039212Yes
220315491549.018.318.3A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
220415491549.045.145.1The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
220515491549.035.635.6Proinflammatory cytokines. C A DinarelloChest200010936147No
220630981549.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbruckGenetics194317247100Yes
220715471547.098.398.3The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
220815471547.037.837.8An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
220915471547.012.612.6The Relation Of Recombination To Mutational Advance. H J MULLERMutat Res196414195748Yes
221015471547.042.842.8Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
221130891544.570.935.5New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
221230891544.566.833.4How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
221346331544.389.129.7A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
221446331544.3105.035.0Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
221546291543.096.832.3The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
221615431543.045.745.7Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
221715431543.033.833.8Huntington's disease. Francis O WalkerLancet200717240289No
221815431543.049.049.0AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
221915411541.037.737.7Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
222015401540.029.929.9E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
222146191539.793.531.2TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
222215391539.045.845.8Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
222315391539.044.644.6Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
222415381538.057.957.9Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
222515381538.033.333.3The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
222615381538.059.659.6The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
222715371537.057.357.3Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
222830741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G SCHMIDT, S J THANNHAUSERJ Biol Chem194521005717Yes
222930731536.560.130.1Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
223030721536.0104.152.0The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
223115361536.035.235.2Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
223230691534.578.439.2Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
223315331533.033.433.4Molecular themes in oncogenesis. J M BishopCell19911988146No
223415331533.040.840.8Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
223515331533.050.450.4Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
223615331533.032.332.3Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
223715331533.042.942.9Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
223830661533.058.829.4Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
223915331533.039.739.7Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
224030651532.590.345.1Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
224145971532.3101.633.9Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
224215321532.056.556.5Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
224315321532.050.250.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
224415321532.026.626.6Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
224530641532.099.749.9Nitric oxide synthases: regulation and function. Ulrich Forstermann, William C SessaEur Heart J201221890489No
224615321532.062.262.2Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
224776591531.8382.176.4Standards for reporting qualitative research: a synthesis of recommendations. Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A CookAcad Med201424979285Yes
224815311531.021.321.3An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
224915311531.043.643.6Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
225045911530.3141.847.3AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. G Paxinos, C R Watson, P C EmsonJ Neurosci Methods19806110810Yes
225115301530.045.045.0Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
225215301530.083.083.0Head and Neck Cancer. Laura Q M ChowN Engl J Med202031893516No
225391791529.8314.052.3StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L SalzbergNat Biotechnol201525690850Yes
225430591529.585.142.5CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
225545881529.3282.094.0Correlation Coefficients: Appropriate Use and Interpretation. Patrick Schober, Christa Boer, Lothar A SchwarteAnesth Analg201829481436No
225661161529.0130.432.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
225715281528.048.048.0Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
225815281528.030.730.7Antigen-Antibody Crossed Electrophoresis. C B LAURELLAnal Biochem196514302464Yes
225915281528.038.538.5Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
226015271527.022.322.3Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
226145801526.7164.654.9Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
226245801526.7149.950.0Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
226315261526.044.844.8Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
226415261526.073.573.5Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
226530511525.599.549.8Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
226615251525.038.638.6Early signals in the mitogenic response. E RozengurtScience19863018928No
226715251525.019.219.2Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
226815251525.038.938.9Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
226945741524.797.732.6Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
227015241524.027.027.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
227130481524.068.734.4Emerging roles of caspase-3 in apoptosis. A G Porter, R U JanickeCell Death Differ199910200555No
227215231523.036.336.3The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
227315221522.050.650.6Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
227415221522.025.325.3Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FUXEActa Physiol Scand Suppl196514319769Yes
227530441522.071.235.6Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
227630421521.0117.858.9Using Effect Size-or Why the P Value Is Not Enough. Gail M Sullivan, Richard FeinnJ Grad Med Educ201223997866Yes
227730391519.562.031.0The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
227815191519.040.840.8Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
227930361518.092.946.5Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
228015181518.037.837.8Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
228130351517.595.447.7Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BackhedNature201222972297No
228215171517.070.370.3Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. Hae-Young KimRestor Dent Endod201323495371Yes
228345501516.7259.586.5Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A WINTER, E A RISLEY, G W NUSSProc Soc Exp Biol Med196214001233Yes
228430331516.598.249.1Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
228530331516.5123.561.8AMPK: guardian of metabolism and mitochondrial homeostasis. Sebastien Herzig, Reuben J ShawNat Rev Mol Cell Biol201828974774No
228615161516.039.739.7Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
228715161516.063.663.6The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
228815161516.041.741.7Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
228930321516.078.539.2Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
229015161516.040.340.3The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
229115161516.042.942.9Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
229230301515.0100.550.2Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
229330281514.058.529.2Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
229490791513.2321.253.5Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
229530261513.056.428.2Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
229615131513.038.338.3The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
229715131513.029.029.0The significance of responses of the genome to challenge. B McClintockScience198415739260No
229830241512.056.828.4Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
229915121512.030.630.6The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
230075591511.8173.634.7Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J BartonBioinformatics200919151095Yes
230115111511.046.846.8Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
230215111511.033.633.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
230315111511.034.534.5Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
230415111511.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MOUNTCASTLEJ Neurophysiol195713439410Yes
230515111511.043.843.8The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
230615091509.040.440.4Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
230730171508.50.00.0Lactic dehydrogenase activity in blood. F WROBLEWSKI, J S LADUEProc Soc Exp Biol Med195513273400Yes
230815081508.045.045.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
230915081508.036.936.9Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
231015081508.038.138.1The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
231115081508.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
231245231507.7134.644.9Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
231330131506.569.634.8Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
231430131506.589.644.8DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
231515061506.048.848.8Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
231615061506.017.917.9The mechanism of muscular contraction. H E HuxleyScience19694181952No
231715061506.025.625.6The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
231830121506.083.341.6Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
231930111505.567.733.9Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
232030111505.575.637.8Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
232115051505.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
232215051505.051.651.6Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
232315041504.032.732.7Tumor suppressor genes. R A WeinbergScience19911659741No
232415041504.052.052.0Lyme disease. A C SteereN Engl J Med19892668764No
232515041504.043.743.7The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
232630071503.579.039.5Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
232715031503.053.753.7The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
232845091503.0138.846.3Mendelian randomization analysis with multiple genetic variants using summarized data. Stephen Burgess, Adam Butterworth, Simon G ThompsonGenet Epidemiol201324114802Yes
232915031503.062.562.5Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
233015021502.043.343.3Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
233115021502.08.08.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SPERRYProc Natl Acad Sci U S A196314077501Yes
233215011501.00.00.0An approximate distribution of estimates of variance components. F E SATTERTHWAITEBiometrics194620287815Yes
233330021501.0101.450.7Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Christoph Hafemeister, Rahul SatijaGenome Biol201931870423Yes
233414991499.050.450.4Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
233544961498.7187.362.4Hepatocellular carcinoma. Alejandro Forner, Maria Reig, Jordi BruixLancet201829307467No
233659931498.2208.152.0MultiQC: summarize analysis results for multiple tools and samples in a single report. Philip Ewels, Mans Magnusson, Sverker Lundin, Max KallerBioinformatics201627312411Yes
233714981498.036.136.1Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
233814981498.036.936.9Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
233914981498.040.840.8Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DomlingChem Rev200616402771No
234029961498.0107.353.6The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
234114971497.038.438.4Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
234229941497.0100.750.4Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
234329941497.093.046.5CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. Jing Huang, Alexander D MacKerellJ Comput Chem201323832629Yes
234414961496.054.954.9Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
234514951495.052.152.1Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
234629881494.075.337.6Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
234744801493.396.432.1OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
234874611492.2268.353.7Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
234914921492.033.833.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
235014921492.039.039.0The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
235114921492.045.445.4Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
235214911491.039.339.3Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
235314911491.030.630.6Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
235429821491.063.831.9Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
235514911491.031.931.9Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
235629801490.0152.976.5Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
235714901490.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
235844691489.745.915.3The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T DODGE, C MITCHELL, D J HANAHANArch Biochem Biophys196314028302Yes
235914891489.043.143.1Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
236014891489.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F ROSENBLATTPsychol Rev195813602029Yes
236114891489.038.838.8Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
236229771488.592.546.2The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
236314881488.034.234.2The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
236414871487.033.233.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
236514871487.040.440.4Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
236629731486.5149.774.8Depression. Gin S Malhi, J John MannLancet201830396512No
236759451486.2252.763.2A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
236814861486.026.326.3Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
236914861486.035.335.3The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
237014861486.053.553.5The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
237114861486.030.930.9Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
237214861486.040.040.0A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
237314851485.031.631.6Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
237429701485.0104.152.0Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
237514841484.036.836.8The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
237629671483.567.934.0Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
237714831483.034.534.5Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
237874151483.0278.755.7DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
237929651482.596.348.1The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
2380133421482.4409.145.5The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
238114821482.095.195.1The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
238214821482.057.957.9Diagnostic and Statistical Manual of Mental Disorders (DSM). Dolores Elaine BattleCodas201324413388Yes
238314821482.096.196.1A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
238414811481.033.633.6PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
2385177631480.21196.699.7The REDCap consortium: Building an international community of software platform partners. Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, J Biomed Inform201931078660Yes
238614801480.035.035.0TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
238714791479.043.843.8Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
238829581479.076.038.0The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
238914791479.010.710.7Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HUXLEYJ Mol Biol196314064165Yes
239014791479.034.434.4Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NOWELLCancer Res196014427849Yes
239144361478.793.631.2Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
239214781478.036.636.6Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
239314781478.056.356.3How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
239429551477.5118.559.2Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
239529551477.554.327.1T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
239644321477.394.931.6Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornoe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
239729541477.067.934.0The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
239814771477.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H ROSENArch Biochem Biophys195713412116Yes
239914771477.029.129.1Human natural killer cells. Michael A CaligiuriBlood200818650461No
240029531476.582.341.1The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
240114761476.047.647.6Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
2402236021475.1625.439.1New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
240314751475.029.729.7Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
240414751475.038.238.2A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
240529501475.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
240614751475.055.355.3The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
240729491474.558.029.0Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
240829491474.567.033.5Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
240914741474.038.138.1Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
241014741474.085.885.8A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
2411103181474.0407.358.2Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
241229481474.0157.878.9The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G GRAY, V P WHITTAKERJ Anat196213901297Yes
241329481474.063.531.8Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
241429471473.572.336.1An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
241529461473.078.039.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
241614731473.047.747.7Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
241729461473.081.740.9Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluisio J D Barros, Vania N HirakataBMC Med Res Methodol200314567763Yes
241844191473.0159.453.1Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
241929451472.576.438.2Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
242029451472.555.327.6Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
242114721472.057.957.9Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
242229421471.097.548.8Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
242314711471.040.040.0Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
242444111470.386.828.9The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
242514701470.047.847.8A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
242614701470.025.825.8The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
242744041468.0150.950.3Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
242829361468.068.434.2The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
242914681468.032.832.8Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
243044031467.7109.736.6LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
243129351467.585.042.5Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
243229351467.554.627.3Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
243343981466.089.529.8Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
243429321466.071.635.8The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
243514661466.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
243643961465.392.430.8NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
243729301465.062.731.4The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
243873251465.0205.041.0Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
243914641464.020.920.9Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
244014641464.032.732.7Simple methods for "staining with lead" at high pH in electron microscopy. M J KARNOVSKYJ Biophys Biochem Cytol196114454024Yes
244114641464.050.050.0Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
244214641464.055.855.8The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
244314631463.034.334.3Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
244414631463.035.935.9The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
244514631463.068.368.3SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
244629221461.085.842.9The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
244714611461.031.431.4The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
244814611461.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BUSHBiochem J195214915960Yes
244914611461.045.645.6How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
245014611461.033.333.3What is a support vector machine? William S NobleNat Biotechnol200617160063No
245114601460.041.241.2The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
245243801460.0133.844.6Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
245314601460.042.842.8The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
245414601460.051.351.3The non-canonical NF-κB pathway in immunity and inflammation. Shao-Cong SunNat Rev Immunol201728580957No
245529191459.599.849.9Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
245629181459.080.040.0Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
245729171458.585.042.5Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
245814581458.035.735.7General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
245914581458.027.627.6Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
246029151457.566.433.2Inflammation, stress, and diabetes. Kathryn E Wellen, Gokhan S HotamisligilJ Clin Invest200515864338No
246129151457.5105.652.8Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
246243721457.3115.538.5TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
246314571457.033.533.5Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
246429141457.052.726.4Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
246529131456.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H CLARKE, J CASALSAm J Trop Med Hyg195813571577Yes
246614561456.040.240.2Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
246714561456.051.151.1The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
246814561456.042.342.3Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
246987311455.2214.035.7A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
247029101455.072.236.13' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
247114551455.029.129.1The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
247214551455.041.541.5Function and information content of DNA methylation. Dirk SchubelerNature201525592537No
247329091454.50.00.0Virus interference. I. The interferon. A ISAACS, J LINDENMANNProc R Soc Lond B Biol Sci195713465720Yes
247414541454.031.131.1Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
247514541454.040.840.8Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
247643601453.3112.237.4Nitric oxide and peroxynitrite in health and disease. Pal Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
247714531453.082.982.9Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
247829051452.537.118.6Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A DAHLSTROEM, K FUXEActa Physiol Scand Suppl196414229500Yes
247943571452.3204.068.0Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
248029041452.079.539.8A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
248129021451.069.034.5Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
248214511451.043.143.1Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
248329011450.570.335.1Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
248429011450.585.542.8bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
248514501450.034.934.9Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
248614501450.030.630.6Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
248728991449.578.239.1Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
248814491449.048.348.3Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
248928981449.059.529.8LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
249028961448.065.532.8Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
249114481448.043.643.6Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
249214481448.00.00.0The critical incident technique. J C FLANAGANPsychol Bull195413177800Yes
249343421447.3109.136.4Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
249472351447.0155.031.0Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
249514471447.017.117.1Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
249657881447.0153.638.4The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
249714471447.038.638.6Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
249828941447.066.633.3C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
249914471447.039.339.3Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
250028931446.50.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J BLOOM, W W RICHARDSONBr J Cancer195713499785Yes
250157861446.5203.951.0Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
250214461446.032.032.0Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
250343381446.086.528.8Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
250414461446.036.836.8T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
250514451445.031.331.3The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
250628901445.071.435.7Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
250728901445.070.135.0Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
250814451445.033.333.3Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
250928901445.00.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D DAVIS, E S MINGIOLIJ Bacteriol195015436457Yes
251028901445.077.438.7Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
251114451445.047.147.1Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
251243331444.393.231.1Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
251386661444.3208.234.7An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
251457771444.2237.259.3Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
251514441444.036.936.9Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
251614441444.029.229.2Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
251728861443.070.335.1Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
251814431443.026.626.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
251914421442.050.550.5Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
252014421442.067.567.5The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
252114411441.034.334.3Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
252214411441.049.849.8The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
252314401440.035.235.2Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
252428801440.0175.988.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H ANTON, D F SAYREJ Pharmacol Exp Ther196214013351Yes
252514391439.029.529.5Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
252614391439.058.758.7Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
252714391439.054.354.3Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
252814391439.040.440.4Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
252943161438.799.533.2Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
253028771438.555.627.8Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
253128771438.5116.158.0Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
2532143821438.2528.552.9MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
253328761438.066.533.2Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
253428761438.058.429.2The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
253557521438.0150.737.7AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
253628751437.587.944.0Liquid phase condensation in cell physiology and disease. Yongdae Shin, Clifford P BrangwynneScience201728935776No
253714371437.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D POULIKNature195713493570Yes
253828741437.069.534.8The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
253914361436.028.028.0Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
254014361436.044.244.2The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
254114361436.053.253.2How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
254214351435.026.926.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
254314351435.016.716.7Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WYMANAdv Protein Chem196414268785No
254414351435.040.440.4Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
254514341434.032.532.5A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
254614341434.012.912.9The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
254728681434.074.337.1New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
254814331433.046.146.1Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
254914331433.036.336.3Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
255028651432.5120.360.1New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Anushka Dongre, Robert A WeinbergNat Rev Mol Cell Biol201930459476No
255142961432.0139.746.6Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
255214321432.032.932.9The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
255314321432.029.629.6A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
255428631431.569.534.8Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
255514311431.033.033.0Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
255628611430.577.738.9Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
255728601430.0106.853.4Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
255828601430.081.340.6Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
255914301430.037.137.1Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
256028581429.083.041.5Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
256114291429.041.641.6Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
256214291429.028.028.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
256328571428.595.547.8A new scale of social desirability independent of psychopathology. D P CROWNE, D MARLOWEJ Consult Psychol196013813058Yes
256428551427.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L HODGKIN, B KATZJ Physiol194918128147Yes
256514271427.067.467.4The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
256628521426.088.844.4Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
256714261426.024.324.3The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
256814261426.039.439.4Endometriosis. Serdar E BulunN Engl J Med200919144942No
256928511425.5153.676.8Sarcopenia. Alfonso J Cruz-Jentoft, Avan A SayerLancet201931171417No
257057001425.0142.035.5Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
257185501425.0221.837.0Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
257242731424.3117.139.0A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
257328481424.069.234.6Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
257428471423.5107.253.6Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
257528471423.5172.586.2Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
257628471423.564.532.2Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
257771171423.4219.443.9CD-HIT: accelerated for clustering the next-generation sequencing data. Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong LiBioinformatics201223060610Yes
257814231423.036.136.1The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
2579170701422.5424.435.4Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, J Gerontol A Biol Sci Med Sci200111253156Yes
258014221422.029.029.0HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
258114221422.031.331.3Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
258228441422.066.533.2Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
258314211421.015.415.4Central dogma of molecular biology. F CrickNature19704913914No
258414211421.025.325.3c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
258514211421.048.348.3Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
258642631421.080.426.8Exosomes: composition, biogenesis and function. Clotilde Thery, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
258714211421.045.145.1Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
258856841421.0143.335.8The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan Shaw, Lancet200516182882Yes
258914211421.035.335.3The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
259014211421.038.638.6The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
259128421421.052.326.1STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
259242611420.3220.073.3Improved metagenomic analysis with Kraken 2. Derrick E Wood, Jennifer Lu, Ben LangmeadGenome Biol201931779668Yes
259314201420.031.131.1Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
259428401420.083.141.5The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
259556791419.8191.447.9Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
259685151419.2297.349.6Second-generation PLINK: rising to the challenge of larger and richer datasets. Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J LeeGigascience201525722852Yes
259714191419.028.928.9Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
259814181418.024.624.6Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
259914181418.033.233.2The basic science of gene therapy. R C MulliganScience19938493530No
260014181418.031.031.0Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
260128351417.582.541.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
260214171417.050.650.6Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
260314171417.035.435.4The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
260414171417.025.225.2ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
260599151416.4287.841.1Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
260614161416.029.129.1Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
260728311415.597.548.8Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
260842461415.394.331.4Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
260928301415.097.949.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
261014151415.043.443.4The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
261114151415.034.234.2Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
261270711414.2131.226.2Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mader, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
261328281414.062.431.2The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
261414141414.032.632.6Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
261514131413.031.931.9Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
261628251412.595.247.6Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
261728251412.562.731.4Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
261828241412.071.135.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
261914121412.025.825.8NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
262042361412.084.228.1Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
262114121412.064.564.5Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
262228231411.542.321.1Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
262328211410.581.640.8Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
262428211410.561.830.9Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
262528201410.0128.764.3Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
262614101410.040.840.8Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
262714101410.028.028.0Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SudhofNature200818923512No
262814091409.020.820.8A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
262914091409.035.435.4Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
263070441408.8248.149.6The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
263142221407.3106.335.4Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
263256291407.2264.566.1The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
263314071407.032.532.5Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
263414071407.029.429.4Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
263528121406.055.527.8Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
263614061406.034.534.5Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
263728121406.071.335.6Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
263814051405.043.143.1Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
263942141404.7119.639.9Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
264014041404.039.039.0A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
264114041404.031.431.4The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
264214041404.022.222.2Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
264314041404.032.732.7Hydrogen sulphide and its therapeutic potential. Csaba SzaboNat Rev Drug Discov200717948022No
264428071403.586.543.2A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
264528071403.583.641.8Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
264628071403.577.438.7Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
264714031403.031.331.3Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
264828051402.5102.451.2Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
264914021402.073.373.3Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
265028041402.074.437.2Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
265114021402.067.167.1Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Nicholas A MeanwellJ Med Chem201829400967No
265284111401.8244.240.7Prodigal: prokaryotic gene recognition and translation initiation site identification. Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J HauserBMC Bioinformatics201020211023Yes
265342041401.396.032.0Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
265428021401.061.630.8Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
265514001400.029.729.7Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
265669951399.0181.436.3Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
265713991399.040.740.7Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
265855941398.5119.229.8Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
265927971398.50.00.0Construct validity in psychological tests. L J CRONBACH, P E MEEHLPsychol Bull195513245896Yes
266027971398.578.539.2Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
266127961398.071.435.7miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
266227941397.060.630.3An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
266313971397.028.228.2Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
266413971397.036.836.8Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
266527931396.561.430.7Immunoassay of endogenous plasma insulin in man. R S YALOW, S A BERSONJ Clin Invest196013846364Yes
266613961396.040.840.8Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
266713961396.026.226.2microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
266813961396.036.936.9Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
266913961396.032.132.1Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
267013961396.043.243.2Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
267127921396.0100.150.0AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
267227911395.5101.150.5Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
267327911395.581.640.8Microdetermination of long-chain fatty acids in plasma and tissues. V P DOLE, H MEINERTZJ Biol Chem196013817286Yes
267413951395.030.730.7Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
267541851395.090.730.2Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
267613941394.029.629.6Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
267713941394.011.011.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
267813941394.024.124.1Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
267927861393.0165.882.9A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
268013931393.034.934.9Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
268113931393.027.527.5The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
268213931393.025.625.6Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
268313931393.046.746.7Electrolytes and interphases in Li-ion batteries and beyond. Kang XuChem Rev201425351820Yes
268413921392.060.360.3Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
268513921392.036.536.5Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
268613921392.030.730.7Optical microcavities. Kerry J VahalaNature200312917698Yes
268713921392.039.239.2Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
268827841392.059.729.9NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
268913921392.069.569.5Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Dimitrios TsikasAnal Biochem201727789233No
269027821391.091.946.0Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
269113901390.049.849.8Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
269213901390.028.428.4Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
269313901390.023.723.7SUMO: a history of modification. Ronald T HayMol Cell200515808504No
269413901390.050.350.3A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
269527801390.080.340.1Opportunities and challenges for a sustainable energy future. Steven Chu, Arun MajumdarNature201222895334No
269641691389.7101.033.7Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C Kearon, J Thromb Haemost200515842354Yes
269727791389.554.627.3Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
269827781389.055.327.6Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
269913891389.036.136.1Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
270013891389.00.00.0The relation of the trail making test to organic brain damage. R M REITANJ Consult Psychol195513263471Yes
270113881388.023.923.9Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
270227761388.067.633.8Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
270313881388.035.535.5Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
270441611387.085.528.5Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
270583221387.0204.134.0Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat RoblesBioinformatics200516081474Yes
270655451386.2149.837.5GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
270713861386.027.427.4Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
270841571385.7147.649.2A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
270927711385.571.235.6A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
271027711385.577.038.5Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
271113851385.043.243.2Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
271213851385.045.845.8Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
271313841384.032.332.3Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
271427651382.596.448.2A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
271513821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SCHNEIDERJ Biol Chem194818886166Yes
271627641382.081.240.6Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
271727631381.570.335.1A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
271813811381.039.139.1Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
271913811381.00.00.0Comparing individual means in the analysis of variance. J W TUKEYBiometrics194918151955Yes
272013811381.036.036.0Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
272113811381.058.858.8Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
272213801380.00.00.0On the psychophysical law. S S STEVENSPsychol Rev195713441853Yes
272313801380.011.411.4Immunological function of the thymus. J F MILLERLancet196114474038Yes
272413801380.033.333.3Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
272513801380.044.944.9The frailty syndrome: definition and natural history. Qian-Li XueClin Geriatr Med201121093718No
272613791379.041.941.9Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
272713791379.031.231.2Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
272813781378.051.551.5Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
272927551377.570.235.1Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WuthrichBiochem Biophys Res Commun19836307308Yes
273027551377.566.633.3Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
273155061376.5125.031.2The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
273227521376.069.834.9Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
273313761376.036.236.2How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
273482531375.5227.237.9Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
273555011375.2105.826.4Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
273613751375.047.047.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
273713751375.043.643.6History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
273813741374.032.132.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
273913741374.022.822.8Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
274013741374.061.561.5Body Mass Index: Obesity, BMI, and Health: A Critical Review. Frank Q NuttallNutr Today201527340299Yes
274113731373.032.732.7Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
274213731373.047.547.5Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
274313731373.035.435.4Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
274413731373.081.081.0COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
274527451372.554.227.1Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
274627441372.00.00.0The respiratory chain and oxidative phosphorylation. B CHANCE, G R WILLIAMSAdv Enzymol Relat Subj Biochem195613313307Yes
274713721372.00.00.0The anterior approach for removal of ruptured cervical disks. R B CLOWARDJ Neurosurg195813599052Yes
274841131371.0120.140.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
274913711371.038.138.1Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
275041111370.394.831.6Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
275127401370.053.726.9A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
275227401370.056.228.1Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
275313701370.035.235.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
275441081369.399.633.2Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
275513691369.046.246.2Interleukin-1. C A DinarelloRev Infect Dis19846369481No
275613691369.027.327.3Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
275713691369.043.443.4Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
275854751368.8116.329.1A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
275954751368.8161.740.4Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
2760136861368.6467.946.8The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
276127361368.086.443.2A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschopeJ Am Coll Cardiol201323684677No
276213681368.078.278.2Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. Janice M MorseQual Health Res201526184336Yes
276313681368.062.262.2Embracing the unknown: disentangling the complexities of the soil microbiome. Noah FiererNat Rev Microbiol201728824177No
276413671367.023.323.3Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
276513671367.045.145.1Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
276627341367.056.528.2Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
276727321366.039.819.9Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
276813661366.033.733.7A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
276913661366.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SMITHIESBiochem J195913638269Yes
277040961365.3125.641.9MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
277113651365.028.628.6Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
277213651365.055.255.2Overview of the IL-1 family in innate inflammation and acquired immunity. Charles A DinarelloImmunol Rev201829247995No
277340931364.390.730.2Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
277413641364.046.746.7Multiple calcium channels and neuronal function. R J MillerScience19872432656No
277527281364.052.526.2Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
277613641364.063.663.6Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
277727271363.572.636.3The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
277813631363.023.123.1The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
277913621362.026.926.9Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
278013621362.043.243.2An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
278113621362.029.729.7The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
278213621362.039.639.6Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
278340841361.3127.742.6Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
278454451361.2171.642.9Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
278513611361.041.741.7Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
278613611361.041.141.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
278713611361.042.342.3The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
278827221361.047.023.5Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
278913611361.044.744.7Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamas RoszerMediators Inflamm201526089604No
279027221361.0103.251.6Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
279127221361.0118.059.0Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Florian R Greten, Sergei I GrivennikovImmunity201931315034No
279227211360.5114.857.4Principal component analysis: a review and recent developments. Ian T Jolliffe, Jorge CadimaPhilos Trans A Math Phys Eng Sci201626953178No
279327201360.072.236.1A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
279413601360.048.448.4The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
279513601360.057.857.8Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
279613601360.034.034.0Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
279713601360.060.460.4The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
279827191359.5135.367.7A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
279954381359.5124.231.1Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
280054371359.2307.977.0Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
280113591359.028.528.5The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
280213591359.035.135.1Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
280354351358.8119.629.9Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
280427171358.5121.160.5Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
280513581358.036.136.1The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
280627161358.064.232.1Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
280713581358.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CAULFIELDJ Biophys Biochem Cytol195713475399Yes
280827161358.060.730.4Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
280913571357.063.563.5Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
281027141357.061.130.6The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
281113571357.036.336.3Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
281227131356.561.830.9NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
281327131356.569.034.5Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
281427121356.0221.6110.8Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
281513561356.066.366.3Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
281627121356.088.044.0Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
281713561356.044.244.2The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
2818122021355.8292.432.5MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
281940661355.399.833.3Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
282013551355.034.234.2Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
282113551355.032.632.6N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
282213541354.025.825.8Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
282313541354.033.533.5Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
282427081354.074.737.4Accurate and robust brain image alignment using boundary-based registration. Douglas N Greve, Bruce FischlNeuroimage200919573611Yes
282540611353.749.516.5Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D SABATINI, K BENSCH, R J BARRNETTJ Cell Biol196313975866Yes
282613531353.035.335.3Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
282713531353.024.324.3Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
282827051352.555.827.9Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
282913521352.023.323.3Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
283054081352.0147.536.9Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
2831108091351.1260.132.5A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
283213511351.016.916.9Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
283313511351.053.053.0The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615Yes
283427001350.060.830.4Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
283513501350.044.044.0Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
283627001350.068.234.1Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
283726991349.557.328.6Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
283826991349.573.036.5What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
283926991349.565.732.9Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
284053981349.5232.958.2Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GokerBMC Bioinformatics201323432962Yes
284113491349.051.851.8Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
284213491349.030.330.3Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
284313491349.044.144.1The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
284440461348.7196.065.3Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
284513481348.048.048.0The case for motivated reasoning. Z KundaPsychol Bull19902270237No
284613481348.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WADDELLJ Lab Clin Med195613346201Yes
284726941347.058.629.3A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
284813471347.029.329.3Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
284913471347.027.227.2Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
285026941347.0121.260.6An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Jesper L R Andersson, Stamatios N SotiropoulosNeuroimage201626481672Yes
285126921346.074.237.1Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
285226901345.086.443.2Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
285313451345.035.535.5Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
285413451345.032.432.4Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
285513451345.030.330.3Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
285613441344.035.535.5The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
285713441344.027.827.8Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
285840311343.7247.182.4How to perform a meta-analysis with R: a practical tutorial. Sara Balduzzi, Gerta Rucker, Guido SchwarzerEvid Based Ment Health201931563865Yes
285926871343.544.722.4Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
286026871343.580.740.4Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
286126871343.575.037.5Inflammatory mechanisms in obesity. Margaret F Gregor, Gokhan S HotamisligilAnnu Rev Immunol201121219177No
286213431343.046.846.8Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
286313431343.035.135.1Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
286426851342.558.529.2Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
286526851342.594.047.0Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde TheryCell201626967288No
286626851342.596.948.5MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Martin Steinegger, Johannes SodingNat Biotechnol201729035372Yes
286740271342.383.928.0A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
286840261342.0120.940.3Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
286926841342.090.245.1Inflammasomes: mechanism of assembly, regulation and signalling. Petr Broz, Vishva M DixitNat Rev Immunol201627291964No
287013411341.046.446.4Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
287113411341.032.632.6Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
287253641341.0133.333.3Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
287313411341.045.645.6Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
287413401340.055.655.6A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
287513401340.034.934.9The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
287613401340.045.245.2The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
287713401340.038.438.4Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
287826801340.078.239.1The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
287940191339.792.430.8Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Ronnback, Elisabeth HanssonNat Rev Neurosci200616371949No
288040171339.095.031.7Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
288113391339.029.929.9Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
288226781339.057.928.9Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
288326771338.557.128.6Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
2884147201338.2401.536.5International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
288513381338.055.055.0Error in medicine. L L LeapeJAMA19947503827Yes
288626761338.052.326.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
288713381338.059.159.1Cellular resistance to infection. G B MACKANESSJ Exp Med196214467923Yes
288813381338.031.931.9Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
288926761338.068.634.3A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
289080271337.8227.637.9The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
289126751337.564.432.2Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
289226741337.049.524.8New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
289313371337.034.734.7The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
289413371337.024.824.8A modified procedure for lead staining of thin sections. G MILLONIGJ Biophys Biochem Cytol196114474176Yes
289513371337.030.030.0Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
289613371337.00.00.0A simple objective technique for measuring flexibility in thinking. E A BERGJ Gen Psychol194818889466Yes
289740101336.7165.355.1Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
289893571336.7587.784.0IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert LanfearMol Biol Evol202032011700Yes
289926731336.560.130.1Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
290013361336.024.624.6Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
290126711335.579.940.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
290213351335.033.533.5Supported membranes: scientific and practical applications. E SackmannScience19968539599No
290313351335.036.336.3The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
290413351335.055.355.3Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Daniel J DruckerCell Metab201829617641No
290526691334.591.445.7Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
290626691334.550.525.2Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
290726691334.562.031.0Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
290826691334.5113.156.5Activation of apoptosis signalling pathways by reactive oxygen species. Maureen Redza-Dutordoir, Diana A Averill-BatesBiochim Biophys Acta201627646922No
290926681334.078.539.2Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
291013341334.024.724.7Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
291113341334.050.750.7Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
291226671333.5100.150.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
291313331333.056.056.0Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
291413331333.029.829.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
291513331333.022.722.7Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
291613331333.031.831.8Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
291713331333.037.737.7Plant productivity and environment. J S BoyerScience198217808529Yes
291813331333.035.735.7Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
291913331333.053.353.3Mediation Analysis: A Practitioner's Guide. Tyler J VanderWeeleAnnu Rev Public Health201626653405No
292013321332.030.730.7Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
292113321332.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BERKSONBiometrics194621001024Yes
292213311331.026.826.8The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
292313311331.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
292439921330.792.130.7METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Goncalo R AbecasisBioinformatics201020616382Yes
292553201330.0129.632.4Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
292613301330.00.00.0Intra-sexual selection in Drosophila. A J BATEMANHeredity (Edinb)194818103134Yes
292726591329.559.929.9Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
292826591329.546.023.0DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
292913291329.028.828.8Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
293013291329.021.921.9Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
293126571328.566.333.1Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
293213281328.052.852.8Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
293353101327.5121.930.5Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar von Heijne, Soren BrunakJ Mol Biol200415223320Yes
293439821327.3116.038.7The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
293513271327.032.132.1The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
293653071326.8135.633.9Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
293739781326.096.132.0The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
293826511325.564.932.5Interneurons of the hippocampus. T F Freund, G BuzsakiHippocampus19968915675No
293926511325.555.027.5The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
294066261325.2161.732.3Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
294126501325.067.333.6Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
294213251325.026.926.9The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
294313251325.025.325.3Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
294413251325.042.142.1Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
294539741324.7104.434.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Gunter Oberdorster, Eva Oberdorster, Jan OberdorsterEnviron Health Perspect200516002369No
294626491324.571.835.9Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
294713241324.034.034.0The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
294826471323.568.134.0Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
294979391323.2279.046.5ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos SimmerlingJ Chem Theory Comput201526574453Yes
2950105801322.5451.356.4Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K ChandaNat Commun201930944313Yes
295126441322.040.420.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
295213221322.061.761.7New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
295313221322.026.426.4Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
295439661322.0111.237.1HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
295526431321.5100.350.1Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
295613211321.017.717.7The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
295726421321.066.233.1Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
295866041320.8181.736.3Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
295913191319.067.767.7Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
296052751318.8107.726.9Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
296139541318.0121.640.5Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
296292251317.9261.237.3pROC: an open-source package for R and S+ to analyze and compare ROC curves. Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus MullerBMC Bioinformatics201121414208Yes
296365881317.6303.660.7Using the framework method for the analysis of qualitative data in multi-disciplinary health research. Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi RedwoodBMC Med Res Methodol201324047204Yes
296426351317.523.911.9Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
296526341317.082.841.4Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
296613171317.031.131.1Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
296726331316.546.523.2Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
296813161316.037.237.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
296926311315.543.621.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
297039461315.3133.344.4The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
297113151315.035.035.0Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
297213151315.023.223.2CD95's deadly mission in the immune system. P H KrammerNature200011048730No
297326301315.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A EDMONDSON, P E STEINERCancer195413160935Yes
297439451315.095.231.7Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
297513151315.038.138.1Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
297626301315.0111.455.7The role of inflammation in depression: from evolutionary imperative to modern treatment target. Andrew H Miller, Charles L RaisonNat Rev Immunol201626711676No
297739441314.796.932.3Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
297826291314.5107.053.5Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
297926291314.575.637.8Crosstalk of reactive oxygen species and NF-κB signaling. Michael J Morgan, Zheng-gang LiuCell Res201121187859No
298039431314.3173.457.8In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
298113141314.046.146.1The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
298213141314.027.427.4Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
298313141314.031.031.0Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
298413141314.034.534.5The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
298526271313.532.616.3A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H VANDENDOOL, P D KRATZJ Chromatogr196314062605Yes
298613131313.034.434.4Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
298713131313.035.435.4The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
298813131313.027.027.0VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
298939381312.7105.835.3Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
299026251312.554.227.1Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
299126251312.572.436.2Mitochondria: in sickness and in health. Jodi Nunnari, Anu SuomalainenCell201222424226No
299278751312.5313.752.3Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark WymerHepatology201626707365No
299313121312.030.730.7Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
299413121312.028.928.9Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
299526231311.549.524.8Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
299626231311.563.031.5The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
299726231311.568.834.4Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
299826221311.079.339.6A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
299926221311.061.330.6Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
300026221311.055.127.6Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
300126221311.051.125.6ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
300213111311.032.332.3Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
300326221311.083.942.0Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
300413101310.043.443.4Bee and wasp venoms. E HabermannScience19724113805No
300513101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F SCHOLANDERJ Biol Chem194720281644Yes
300665451309.0315.863.2Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
300726181309.059.329.6Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
300813091309.039.539.5Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
300913091309.030.330.3Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
301026171308.577.338.6An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
301126171308.596.048.0The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
301226171308.5138.569.2Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R GUILLARD, J H RYTHERCan J Microbiol196213902807Yes
301326171308.565.732.9BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
301413081308.083.983.9The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
301526161308.050.125.1CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
301613081308.043.743.7Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
301713081308.031.031.0Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
301826161308.044.922.4Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
301913081308.028.628.6Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
302013081308.034.934.9Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
302113081308.041.341.3Drug transport across the blood-brain barrier. William M PardridgeJ Cereb Blood Flow Metab201222929442No
302226151307.574.037.0Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
302313071307.034.734.7Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
302413071307.029.829.8Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
302513071307.032.632.6Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
302613071307.039.439.4Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
302713071307.025.825.8Searching for intellectual turning points: progressive knowledge domain visualization. Chaomei ChenProc Natl Acad Sci U S A200414724295Yes
302826141307.056.628.3Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
302913071307.028.828.8Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
303013061306.00.00.0A production of amino acids under possible primitive earth conditions. S L MILLERScience195313056598Yes
303113061306.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FARRJ Infect Dis195813611294Yes
303213061306.038.238.2A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
303365281305.6245.549.1Frailty in elderly people. Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth RockwoodLancet201323395245No
303413051305.028.828.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
303526101305.062.631.3Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
303613051305.026.926.9Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
303713051305.00.00.0Agammaglobulinemia. O C BRUTONPediatrics195214929630Yes
303813041304.033.733.7The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
303926081304.059.329.6ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoit D'Autreaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
304013041304.024.424.4Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
304126081304.056.928.4Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
304239121304.096.232.1Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
304313041304.053.653.6The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
304426061303.082.841.4Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
304513031303.046.446.4Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
304626061303.076.938.5Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
304726041302.099.449.7A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
304826041302.052.926.4The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
304939051301.7107.835.9Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681Yes
305026031301.551.725.9TM-align: a protein structure alignment algorithm based on the TM-score. Yang Zhang, Jeffrey SkolnickNucleic Acids Res200515849316Yes
305139041301.390.730.2Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
305213011301.029.729.7Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
305313011301.033.733.7Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
305413001300.031.031.0Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
305513001300.030.230.2Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
305626001300.066.733.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
305713001300.025.925.9The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
305825991299.5106.853.4Designing hydrogels for controlled drug delivery. Jianyu Li, David J MooneyNat Rev Mater201629657852Yes
305925981299.094.047.0Tumour heterogeneity and resistance to cancer therapies. Ibiayi Dagogo-Jack, Alice T ShawNat Rev Clin Oncol201829115304No
306025971298.580.040.0The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
306177901298.3171.428.6Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
306225961298.047.923.9The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
306312981298.024.924.9Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
306412981298.032.532.5Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
3065129721297.2312.431.2Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
306612971297.030.930.9Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
306712971297.042.142.1Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
306825941297.076.038.0Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
306925941297.044.322.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
307012971297.028.728.7Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
307112971297.024.824.8Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
307212961296.044.144.1Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
307338881296.089.029.7Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
307451841296.0269.767.4Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. Shaoqing Ren, Kaiming He, Ross Girshick, Jian SunIEEE Trans Pattern Anal Mach Intell201727295650Yes
307512951295.032.132.1Drug delivery and targeting. R LangerNature19989579855No
307612951295.050.950.9The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
307712951295.027.427.4S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
307812951295.035.135.1Depression in the elderly. George S AlexopoulosLancet200515936426No
307912951295.039.539.5Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
308025891294.582.641.3Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
308138831294.387.129.0Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
308225881294.049.524.8Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
308312941294.038.638.6Determining association constants from titration experiments in supramolecular chemistry. Pall ThordarsonChem Soc Rev201121125111Yes
308412931293.059.059.0A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
308512931293.027.227.2Human papillomavirus and cervical cancer. Eileen M BurdClin Microbiol Rev200312525422No
308612931293.039.439.4The inflammatory response in myocardial injury, repair, and remodelling. Nikolaos G FrangogiannisNat Rev Cardiol201424663091No
308712931293.051.951.9Cystic fibrosis. J Stuart ElbornLancet201627140670No
308825861293.0164.982.5The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
308912921292.042.342.3Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
309012921292.014.314.3A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
309138751291.7176.358.8Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
3092116201291.1280.331.1Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
309312901290.036.136.1Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
309425801290.065.432.7A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
309525791289.548.324.1Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
309625791289.554.927.4The Polycomb complex PRC2 and its mark in life. Raphael Margueron, Danny ReinbergNature201121248841No
309712891289.039.439.4Somatostatin. S ReichlinN Engl J Med19836139753No
309812891289.031.931.9Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
309912891289.030.430.4A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
310012891289.031.631.6Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
310112891289.027.027.0r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
310225781289.051.825.9Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
310312891289.044.044.0Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjostromJ Intern Med201323163728No
310425771288.565.532.8Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
310525761288.089.244.6Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
310612881288.036.936.9Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BoyumScand J Clin Lab Invest Suppl19684179066Yes
310712881288.029.829.8Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
310812881288.029.629.6Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
310925741287.060.730.4Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
311012861286.038.838.8Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
311112861286.037.937.9Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
311212861286.026.926.9Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
311325721286.054.027.0Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
311412861286.046.146.1Epidemiology and risk factors for IBD. Ashwin N AnanthakrishnanNat Rev Gastroenterol Hepatol201525732745No
311538571285.7107.835.9Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
311612851285.025.325.3Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
311725701285.078.639.3Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
311812851285.073.173.1Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WINTERNature196214007593Yes
311912851285.040.540.5Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
312038551285.092.130.7Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
312125691284.565.432.7Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
312225691284.559.329.6Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
312325671283.557.428.7Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
312425671283.513.56.8Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J TODARO, H GREENJ Cell Biol196313985244Yes
312525661283.066.233.1Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundstrom, K NilssonInt J Cancer1976178611Yes
312612831283.039.039.0The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
312712821282.046.246.2The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
312812821282.048.948.9A simple method for determination of serum catalase activity and revision of reference range. L GothClin Chim Acta19912029780Yes
312925641282.070.035.0Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
313012821282.034.434.4Rethinking schizophrenia. Thomas R InselNature201021068826No
313125631281.548.924.4Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
313225621281.066.733.4Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
313312801280.027.627.6Brain tumors. L M DeAngelisN Engl J Med200111150363No
313412801280.026.526.5Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
313525601280.058.529.2Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
313625601280.050.625.3NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
313712801280.00.00.0The antidiuretic hormone and the factors which determine its release. E B VERNEYProc R Soc Lond B Biol Sci194718918876Yes
313812801280.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KALCKARJ Biol Chem194720285041Yes
313912801280.054.654.6Review of the psychometric evidence of the perceived stress scale. Eun-Hyun LeeAsian Nurs Res (Korean Soc Nurs Sci)201225031113Yes
314051191279.8143.735.9Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
314138381279.3115.238.4PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
314212791279.030.730.7The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
314312791279.037.837.8Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
314412791279.030.630.6Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
314589521278.9223.531.9Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
314612781278.025.425.4Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
314712781278.027.827.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
314825561278.069.034.5Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
314925551277.584.842.4A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
315012771277.031.631.6Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
315125541277.097.348.6Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Michael A Gimbrone, Guillermo Garcia-CardenaCirc Res201626892962No
315238301276.7112.937.6Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
315325531276.5101.951.0The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Naatanen, T PictonPsychophysiology19873615753Yes
315425521276.057.128.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
315525521276.049.624.8A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
315612761276.025.725.7Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
315725511275.580.740.4Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
315812751275.040.440.4Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
315925501275.052.426.2Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
316012751275.061.161.1Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
316112751275.070.570.5The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A ROSEBull World Health Organ196213974778Yes
316212751275.025.125.1Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
316312751275.032.332.3Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
316425491274.552.026.0Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
316512741274.036.136.1Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
316625471273.577.838.9Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
316725471273.561.730.9Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
316812731273.032.432.4A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
316925461273.050.025.0Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
317038181272.7132.244.1Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Dmitry B Zorov, Magdalena Juhaszova, Steven J SollottPhysiol Rev201424987008No
317125451272.548.524.2Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
317212721272.030.230.2Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
317312721272.020.920.9Antigen receptor tail clue. M RethNature19892927501Yes
317412721272.025.925.9Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
3175139871271.5323.329.4New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
317612711271.034.034.0Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
317712701270.022.322.3Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
317812701270.033.433.4Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
317925391269.598.249.1Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
318025391269.577.838.9Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
318112691269.035.935.9Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
318238071269.088.429.5Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
318325381269.0302.3151.2The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Karin E de Visser, Johanna A JoyceCancer Cell202336917948No
318412681268.033.733.7Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
318512681268.021.521.5Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
318612681268.046.346.3Substance P. B PernowPharmacol Rev19836196797No
318712681268.024.024.0A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
318812681268.029.929.9Identifying and characterizing binding sites and assessing druggability. Thomas A HalgrenJ Chem Inf Model200919434839Yes
318912671267.022.622.6Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
319012671267.032.732.7Philosophical conceptions of the self: implications for cognitive science. Shaun GallagherTrends Cogn Sci200010637618Yes
319112671267.029.629.6Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
319212671267.035.835.8pegas: an R package for population genetics with an integrated-modular approach. Emmanuel ParadisBioinformatics201020080509Yes
319312671267.032.032.0AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
319450671266.8131.032.8Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Madler, Ning LiScience200616456071No
319525331266.572.736.4Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
319650661266.5116.429.1Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
319725331266.565.032.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
319812661266.036.736.7Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
319912661266.034.534.5Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
320012661266.020.420.4Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
320125311265.566.933.5Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
320225301265.057.628.8Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
320312651265.026.526.5How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
320425291264.557.328.6ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
320512641264.032.132.1Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
320612641264.034.834.8High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
320737921264.091.130.4The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
320812641264.046.646.6Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
320925281264.0107.753.9Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Luigi Ferrucci, Elisa FabbriNat Rev Cardiol201830065258No
321012631263.034.234.2Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
321112631263.039.139.1Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
321212631263.027.527.5Viruses in the sea. Curtis A SuttleNature200516163346No
321325261263.065.432.7Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
321437891263.0146.748.9Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Antonio Ayala, Mario F Munoz, Sandro ArguellesOxid Med Cell Longev201424999379No
321575741262.3162.327.1Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
321625241262.076.738.4Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
321712621262.025.725.7Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
321812611261.035.935.9Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
321912611261.029.429.4Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
322012611261.028.828.8ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
322112611261.033.733.7Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
322225211260.590.545.2Comparative Protein Structure Modeling Using MODELLER. Benjamin Webb, Andrej SaliCurr Protoc Bioinformatics201627322406Yes
322337811260.3105.535.2SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stephane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
322412601260.035.535.5A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
322512601260.026.926.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
322612601260.024.524.5Searching for genetic determinants in the new millennium. N J RischNature200010866211No
322737791259.7125.041.7Ecological momentary assessment. Saul Shiffman, Arthur A Stone, Michael R HuffordAnnu Rev Clin Psychol200818509902No
322825191259.568.734.4Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
322925181259.060.930.4Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
323012591259.025.225.2Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
323112591259.026.426.4Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
323212581258.060.460.4Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
323312581258.028.528.5Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
323412581258.027.827.8Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
323512581258.025.625.6SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
323612581258.00.00.0A modification of receptor theory. R P STEPHENSONBr J Pharmacol Chemother195613383117Yes
323737741258.097.532.5FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Morgan N Price, Paramvir S Dehal, Adam P ArkinMol Biol Evol200919377059Yes
323825161258.069.534.8Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
323925151257.591.545.8The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
324025151257.5103.151.5Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Douglas J Morrison, Tom PrestonGut Microbes201626963409No
324112571257.044.544.5Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
324212571257.054.154.1Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
324312571257.031.431.4Apoptosis. J J CohenImmunol Today19938466628No
324412571257.026.026.0The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
324525141257.052.426.2Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
324625141257.0129.864.9Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. Amy J H Kind, William R BuckinghamN Engl J Med201829949490Yes
324725131256.568.234.1Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
324825131256.578.039.0Infernal 1.1: 100-fold faster RNA homology searches. Eric P Nawrocki, Sean R EddyBioinformatics201324008419Yes
324912561256.046.346.3Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
325012561256.031.631.6Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
325112561256.025.425.4Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
325212561256.030.830.8Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
325312561256.034.134.1Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
325412551255.030.830.8Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
325512551255.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MEDAWARBr J Exp Pathol194818865105Yes
325662741254.8167.633.5Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
325712541254.042.042.0Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
325812541254.024.524.5The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. P StothardBiotechniques200010868275Yes
325912541254.022.622.6Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
3260100311253.9304.738.1Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S MarksAm J Prev Med19989635069Yes
326112531253.046.746.7A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
326225061253.057.628.8DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
326312531253.015.615.6The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
326412531253.045.145.1Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
326525041252.048.524.2Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
326612521252.022.822.8Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
326712521252.024.524.5STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
326812521252.032.332.3Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
326912521252.040.040.0Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
327012521252.022.522.5Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
327175081251.3277.346.2GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin ZhangNucleic Acids Res201728407145Yes
327225021251.064.232.1Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
327312511251.030.830.8An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
327412511251.042.142.1Human milk oligosaccharides: every baby needs a sugar mama. Lars BodeGlycobiology201222513036No
327525011250.5118.859.4Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
327612501250.021.321.3NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
327712501250.054.854.8A decade of immune-checkpoint inhibitors in cancer therapy. Caroline RobertNat Commun202032732879Yes
327824991249.566.133.0Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
327924991249.557.828.9Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. In Suk Joung, Thomas E CheathamJ Phys Chem B200818593145Yes
328012491249.024.924.9Evolution of ageing. T B KirkwoodNature1977593350Yes
328124981249.062.631.3Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
328224981249.048.024.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
328312491249.030.030.0Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
328474941249.0164.727.4Enzymatic assembly of DNA molecules up to several hundred kilobases. Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O SmithNat Methods200919363495Yes
328524981249.067.033.5Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Marie Cargnello, Philippe P RouxMicrobiol Mol Biol Rev201121372320No
328662411248.2113.122.6The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
328712481248.024.624.6Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
328812481248.062.462.4Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
328987361248.0265.237.9Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
329012481248.035.035.0The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
329112481248.030.230.2Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
329224951247.572.536.2The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
329324941247.084.742.4A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
329412471247.023.423.4Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
329512461246.027.327.3Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
329612461246.00.00.0Sequential tests for the detection of linkage. N E MORTONAm J Hum Genet195513258560Yes
329737371245.775.625.25-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
3298137031245.7251.222.8Model-based analysis of ChIP-Seq (MACS). Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley LiuGenome Biol200818798982Yes
329924911245.568.834.4Regulation of type I interferon responses. Lionel B Ivashkiv, Laura T DonlinNat Rev Immunol201424362405No
330024901245.088.344.1Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
330112451245.026.626.6Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
330212451245.033.133.1MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
330324891244.591.645.8Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
330412441244.037.137.1MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
330524871243.560.930.4Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
330624861243.067.633.8Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
330712431243.041.941.9How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
330812431243.029.329.3Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
330912431243.035.335.3The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. John DuncanTrends Cogn Sci201020171926No
331012421242.037.737.7Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
331112421242.032.732.7What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
331212421242.042.042.0Considerations in determining sample size for pilot studies. Melody A HertzogRes Nurs Health200818183564No
331337241241.395.631.9Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
331462051241.0191.338.3Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
331512411241.036.036.0The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
331674461241.0134.922.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
331712411241.015.415.4Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M VAN ROSSUMArch Int Pharmacodyn Ther196313996119Yes
331812401240.055.555.5Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
331912401240.039.139.1Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
332012401240.043.243.2Type 2 inflammation in asthma--present in most, absent in many. John V FahyNat Rev Immunol201525534623No
332124791239.555.127.6The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
332237181239.373.824.6Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
332312391239.058.658.6Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
332412391239.021.021.0Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
332524781239.053.226.6The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N AMES, D T DUBINJ Biol Chem196013793161Yes
332612391239.047.547.5Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
332712391239.056.456.4The expanding regulatory mechanisms and cellular functions of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol202032366901No
332824771238.550.025.0Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
332912381238.058.558.5The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
333012381238.036.536.5Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
333137141238.071.123.7SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
333224761238.091.345.6Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Jerome Galon, Daniela BruniNat Rev Drug Discov201930610226No
333312371237.026.826.8Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
333412371237.029.029.0Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
333512371237.023.123.1Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
333612371237.036.836.8Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
333737101236.793.231.1Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
333824731236.582.141.0Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
333961821236.4205.041.0Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
334024711235.539.319.6A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
334112351235.025.225.2Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
334224701235.064.532.2Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
334324701235.068.934.5Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
334424701235.051.825.9Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
334524701235.0186.993.5Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
334624691234.552.026.0Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
334724691234.558.029.0Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
3348123421234.2394.139.4The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
334912341234.027.327.3Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
335012341234.031.331.3The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
335112341234.023.823.8Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
335212341234.031.631.6Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
335324671233.548.924.4The mammalian unfolded protein response. Martin Schroder, Randal J KaufmanAnnu Rev Biochem200515952902No
335412331233.030.530.5Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsakiNeuroscience19892687720No
335512331233.033.833.8ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
335624651232.563.231.6Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
335724631231.569.734.9The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
335812311231.025.725.7Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
335912311231.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BUONOCOREJ Dent Res195513271655Yes
336024621231.058.029.0The regulation of IL-10 production by immune cells. Margarida Saraiva, Anne O'GarraNat Rev Immunol201020154735No
336112301230.033.833.8Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
336212301230.032.832.8Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
336312291229.031.231.2Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
336412291229.033.633.6Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
336512291229.026.026.0Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
336612281228.028.428.4Growth factors and cancer. S A AaronsonScience19911659742No
336712281228.0109.1109.1The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
336824561228.088.544.2Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
336912281228.025.025.0MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
337012281228.060.060.0Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Hector F Escobar-MorrealeNat Rev Endocrinol201829569621No
337136821227.3103.134.4A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
337224541227.053.626.8Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
337312271227.076.376.3Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
337412271227.030.530.5Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
337512271227.023.623.6Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
337624541227.072.636.3Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
337785861226.6562.080.3TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui XiaMol Plant202032585190Yes
337824531226.554.227.1Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
337912261226.025.125.1Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
338012261226.00.00.0Voluntary strength and fatigue. P A MERTONJ Physiol195413152698Yes
338112261226.030.030.0Optogenetics. Karl DeisserothNat Methods201121191368Yes
338236771225.782.227.4Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernan, B BrumbackEpidemiology200010955408Yes
338312251225.058.358.3ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
338412251225.022.122.1Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
338512251225.029.029.0Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" F D HaldanePhys Rev Lett198810038961Yes
338624481224.082.441.2The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
338724481224.071.635.8Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
338812241224.024.424.4Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
338924481224.061.230.6Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
339012241224.040.840.8DREADDs for Neuroscientists. Bryan L RothNeuron201626889809No
339136711223.7101.934.0Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
339236711223.793.131.0Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
339336711223.7179.759.9Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Yan Zheng, Sylvia H Ley, Frank B HuNat Rev Endocrinol201829219149No
339424471223.5124.762.4The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
339524471223.568.634.3Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
339624471223.577.038.5Toll-like receptor signaling pathways. Takumi Kawasaki, Taro KawaiFront Immunol201425309543No
339736701223.360.120.0A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, Rene Bernards, Reuven AgamiScience200211910072Yes
339848931223.2139.935.0Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
339912231223.028.328.3The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
340036691223.0127.242.4Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
340112231223.025.725.7Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
340212231223.030.830.8The quantum internet. H J KimbleNature200818563153Yes
340312221222.074.174.1Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
340412221222.028.028.0Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
340512221222.022.522.5IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
340612221222.045.445.4The angular gyrus: multiple functions and multiple subdivisions. Mohamed L SeghierNeuroscientist201322547530No
340712221222.0128.4128.4Sample size determination and power analysis using the G*Power software. Hyun KangJ Educ Eval Health Prof202134325496No
340824431221.562.231.1Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
340912211221.023.723.7Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
341012211221.033.933.9Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Masabumi ShibuyaGenes Cancer201122866201Yes
341112211221.043.743.7Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Georgia SalantiRes Synth Methods201226062083Yes
341224411220.557.328.6Interaction revisited: the difference between two estimates. Douglas G Altman, J Martin BlandBMJ200312543843No
341324411220.552.326.1microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
341412201220.040.640.6The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
341512201220.035.735.7The mental health continuum: from languishing to flourishing in life. Corey L M KeyesJ Health Soc Behav200212096700Yes
341612201220.031.031.0Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
341736571219.072.124.0Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
341812191219.031.731.7Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532Yes
341936561218.780.526.8Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
342012181218.033.033.0What is synergy? M C BerenbaumPharmacol Rev19892692037No
342112181218.063.563.5A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
342212181218.059.159.1Osseointegration and its experimental background. P I BranemarkJ Prosthet Dent19836352924No
342324361218.026.213.1The Aggregation Of Blood Platelets. G V BORN, M J CROSSJ Physiol196314056485Yes
342448701217.590.622.6Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
342512171217.029.029.0Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
342612171217.026.826.8The columnar organization of the neocortex. V B MountcastleBrain19979153131No
342712171217.037.737.7Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan St B T EvansAnnu Rev Psychol200818154502No
342836511217.0120.840.3Social relationships and mortality risk: a meta-analytic review. Julianne Holt-Lunstad, Timothy B Smith, J Bradley LaytonPLoS Med201020668659No
342924321216.0104.952.5Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
343012161216.029.029.0The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
343124321216.042.621.3Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
343212161216.022.522.5Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
343312161216.025.325.3Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
343412151215.048.348.3Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
343512151215.030.230.2Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
343612151215.029.729.7Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
343724301215.045.922.9Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
343824301215.091.645.8The Human Intestinal Microbiome in Health and Disease. Susan V Lynch, Oluf PedersenN Engl J Med201627974040No
343936451215.0138.046.0The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris BoshoffNature201829364287No
344024291214.552.226.1Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
344112141214.032.732.7Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
344224281214.068.234.1Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
344324271213.534.917.4High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
344436401213.3110.336.8Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
344512131213.035.935.9The mysteries of lipoprotein(a). G UtermannScience19892530631No
344612131213.042.142.1Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
344724261213.097.448.7The Tumor Microenvironment Innately Modulates Cancer Progression. Dominique C Hinshaw, Lalita A ShevdeCancer Res201931350295No
344872771212.8172.028.7Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, Lancet200212493255Yes
344924251212.597.748.9Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
345048501212.5124.131.0Gene ontology analysis for RNA-seq: accounting for selection bias. Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia OshlackGenome Biol201020132535Yes
345112121212.063.463.4The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
345212121212.038.238.2Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
345324241212.064.132.0Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
345412121212.026.226.2Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
345512121212.029.729.7The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
345624241212.043.621.8The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
345724241212.050.725.4Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
345812121212.022.922.9Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
345912121212.029.329.3Overview of the immune response. David D ChaplinJ Allergy Clin Immunol201020176265No
346012121212.040.140.1What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
346112121212.0313.0313.0A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn. Tian LuJ Chem Phys202439189657Yes
346236341211.3167.655.9Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
346312111211.050.350.3A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
346412111211.027.827.8Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
346512111211.028.728.7Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. R ZahorecBratisl Lek Listy200111723675Yes
346624221211.052.926.4Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794Yes
346712111211.017.517.5The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E HOPE-SIMPSONProc R Soc Med196514267505Yes
346824221211.044.322.1Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
346912111211.032.332.3On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
347012111211.033.733.7Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
347124221211.087.743.9Gut microbiota, metabolites and host immunity. Michelle G Rooks, Wendy S GarrettNat Rev Immunol201627231050No
347236321210.7181.360.4Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
347324211210.579.639.8Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
347412101210.052.152.1Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
347512101210.026.626.6The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
347660471209.4211.842.4Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
347724181209.068.834.4Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
347812091209.037.837.8The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
347924171208.5105.852.9Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
348024171208.548.424.2The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
348136251208.3119.639.9Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
348212081208.038.438.4Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
348312081208.034.834.8On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
348424151207.556.728.4Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
348512071207.018.218.2Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
348624141207.052.726.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
348724141207.058.929.4Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
348812071207.025.425.4The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
348912071207.033.033.0On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
349012071207.030.930.9Inflammation 2010: new adventures of an old flame. Ruslan MedzhitovCell201020303867No
349124141207.078.539.2The gut microbiota--masters of host development and physiology. Felix Sommer, Fredrik BackhedNat Rev Microbiol201323435359No
349224131206.594.847.4Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. T J Cole, T LobsteinPediatr Obes201222715120Yes
349312061206.041.341.3Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
349412061206.033.733.76-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
349512061206.020.420.4Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
349612061206.032.832.8The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
349712061206.019.119.1Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
349812061206.010.010.0A New Serum Type System In Man--The Lp System. K BERGActa Pathol Microbiol Scand196314064818Yes
349936181206.075.925.3Population structure and eigenanalysis. Nick Patterson, Alkes L Price, David ReichPLoS Genet200617194218Yes
350048231205.8122.330.6Mussel-inspired surface chemistry for multifunctional coatings. Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B MessersmithScience200717947576Yes
350136171205.791.630.5Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
350224111205.587.043.5Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
350324111205.556.128.1Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
350472311205.2244.240.7The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
3505120521205.2264.226.4Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus SchultenJ Comput Chem200516222654Yes
350612051205.049.149.1Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
350712051205.033.233.2Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. J C MorrisInt Psychogeriatr19979447441Yes
350812051205.033.533.5Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Rakesh K JainCancer Cell201425517747No
350936121204.0110.436.8The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
351012041204.052.952.9Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
351148151203.8114.828.7Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
351224071203.575.337.6Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
351312031203.021.321.3Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
351412031203.044.644.6Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
351512031203.031.131.1Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
351612031203.046.346.3Vitamin D metabolism, mechanism of action, and clinical applications. Daniel D BikleChem Biol201424529992No
351724061203.082.341.1ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Tauno Metsalu, Jaak ViloNucleic Acids Res201525969447Yes
351824051202.548.024.0Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
351960121202.4140.828.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
352012021202.029.729.7Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
352124041202.075.637.8Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
352224041202.052.126.1Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
352312021202.030.530.5Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
352412021202.032.132.1Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
352536051201.7107.535.8Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Irith Wiegand, Kai Hilpert, Robert E W HancockNat Protoc200818274517Yes
352624031201.548.224.1Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
352712011201.036.636.6Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
352824021201.046.523.2Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
352936031201.085.628.5Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
353012011201.020.920.9Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
353124021201.050.925.4Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
353212011201.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C CHANGNature195114882325Yes
353312011201.030.530.5Neural stimulation and recording electrodes. Stuart F CoganAnnu Rev Biomed Eng200818429704No
353412011201.044.644.6Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). F BerenbaumOsteoarthritis Cartilage201323194896No
353524001200.095.447.7A real-time QRS detection algorithm. J Pan, W J TompkinsIEEE Trans Biomed Eng19853997178Yes
353672001200.0150.825.1Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
353724001200.049.824.9Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
353824001200.048.824.4Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
353912001200.027.527.5Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Andrey A ShabalinBioinformatics201222492648Yes
354035991199.771.623.9Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
3541107941199.3352.139.1A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
354283941199.1160.022.9Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
354311991199.056.756.7The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
354411991199.036.536.5Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
354511991199.039.439.4beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
354611991199.034.834.8Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
354723981199.063.531.8Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
354847941198.5106.626.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
354911981198.044.144.1Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
355011981198.040.440.4The pain self-efficacy questionnaire: Taking pain into account. Michael K NicholasEur J Pain200716446108Yes
355111981198.030.830.8A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
355235921197.393.931.3A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
355347891197.2212.053.0An ecological perspective on health promotion programs. K R McLeroy, D Bibeau, A Steckler, K GlanzHealth Educ Q19883068205No
355411971197.039.939.9An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
355511971197.028.328.3Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
355611971197.027.427.4Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
355723941197.040.020.0A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
355811971197.032.332.3The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
355959851197.0234.246.8KEGG: new perspectives on genomes, pathways, diseases and drugs. Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae MorishimaNucleic Acids Res201727899662Yes
356035901196.7174.558.2Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. Mojtaba Vaismoradi, Hannele Turunen, Terese BondasNurs Health Sci201323480423No
356123931196.552.226.1Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
356211961196.045.245.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
356311961196.032.132.1Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
356411961196.024.724.7Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
356523921196.064.132.0Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
356611961196.024.424.4Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
356723901195.037.618.8Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
356811951195.022.122.1VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
356911951195.025.125.1G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
357011951195.033.933.9Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
357111951195.035.235.2Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
357211941194.039.239.2Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
357311941194.011.511.5Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
357411941194.033.633.6Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
357511931193.034.034.0Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
357611931193.028.828.8Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
357711931193.025.825.8Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
357811931193.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
357911931193.043.943.9Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. Walter S LealAnnu Rev Entomol201323020622No
358035771192.3101.433.8Macrophage biology in development, homeostasis and disease. Thomas A Wynn, Ajay Chawla, Jeffrey W PollardNature201323619691No
358123841192.095.447.7Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
358211921192.021.921.9Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
358311921192.027.027.0Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
358423841192.087.543.8OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. David M Emms, Steven KellyGenome Biol201526243257Yes
358523831191.5201.6100.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
358635741191.396.632.2Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
358735741191.390.630.2Fluorine in pharmaceuticals: looking beyond intuition. Klaus Muller, Christoph Faeh, Francois DiederichScience200717901324No
358811911191.067.667.6Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
358911911191.030.930.9Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
359011911191.029.329.3Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
359111911191.029.329.3Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
359223821191.058.029.0Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
359311911191.026.526.5Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
359411911191.023.323.3Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
359511901190.037.037.0Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
359611901190.023.523.5The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DUNCOMBEClin Chim Acta196414122498Yes
359711901190.023.023.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B ASHWORTHPractitioner196414143329Yes
359811901190.028.428.4Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
359923791189.564.332.1Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
360047561189.0109.027.2Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
360123781189.049.524.8Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
360211891189.027.227.2Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
360311891189.041.241.2Autonomic nervous system activity in emotion: a review. Sylvia D KreibigBiol Psychol201020371374No
360411891189.046.146.1Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Laura J JulianArthritis Care Res (Hoboken)201122588767No
360559451189.0266.453.3VSEARCH: a versatile open source tool for metagenomics. Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic MahePeerJ201627781170Yes
360623781189.0115.557.8Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Laura M Doyle, Michael Zhuo WangCells201931311206No
360735661188.7161.253.7The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Karen V Swanson, Meng Deng, Jenny P-Y TingNat Rev Immunol201931036962No
3608166391188.5349.625.0Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
360911881188.034.434.4Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
361011881188.026.126.1Sjögren's syndrome. Robert I FoxLancet200516039337No
361123761188.061.430.7The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Maria M Mihaylova, Reuben J ShawNat Cell Biol201121892142No
361259381187.6190.838.2Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
361323751187.556.528.2The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
361423751187.551.125.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
361523751187.559.429.7Cancer epigenetics: from mechanism to therapy. Mark A Dawson, Tony KouzaridesCell201222770212No
361611871187.053.153.1Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
361711871187.00.00.0The powerful placebo. H K BEECHERJ Am Med Assoc195513271123Yes
361823741187.073.236.6Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
361923731186.557.328.6Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Sophia Y Lunt, Matthew G Vander HeidenAnnu Rev Cell Dev Biol201121985671No
362023721186.0110.755.4Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
362111861186.030.730.7Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
362211861186.035.635.6The Danish Cancer Registry. Marianne Lundkjaer GjerstorffScand J Public Health201121775350Yes
362323711185.581.040.5Superoxide dismutases: I. Occurrence in higher plants. C N Giannopolitis, S K RiesPlant Physiol197716659839Yes
362435561185.375.625.2Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
362535551185.070.723.6Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
362611851185.030.730.7Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
362711851185.038.838.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
362811851185.026.026.0Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
362911851185.039.439.4Constructive and unconstructive repetitive thought. Edward R WatkinsPsychol Bull200818298268No
363011851185.033.933.9Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BunzliChem Rev201020151630No
363123701185.068.334.1Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
363211851185.032.532.5Cyclin-dependent kinases. Marcos MalumbresGenome Biol201425180339No
363323691184.576.738.4Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
363411841184.053.053.0Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
363511841184.021.321.3The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
363611841184.023.823.8Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
363711841184.032.732.7Cellular and molecular mechanisms of renal fibrosis. Youhua LiuNat Rev Nephrol201122009250No
363823671183.585.042.5The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
363923671183.549.724.9Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
364035501183.369.723.2Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Juri Rappsilber, Matthias Mann, Yasushi IshihamaNat Protoc200717703201Yes
364135501183.3137.946.0Rheumatoid arthritis. Josef S Smolen, Daniel Aletaha, Iain B McInnesLancet201627156434No
364211831183.026.326.3Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
364323661183.0347.8173.9Sample sizes for saturation in qualitative research: A systematic review of empirical tests. Monique Hennink, Bonnie N KaiserSoc Sci Med202234785096Yes
364423651182.572.936.5Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
364523651182.542.721.4Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
364611821182.036.836.8Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
364723631181.550.525.2Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
364859071181.4187.737.5A simulation study of the number of events per variable in logistic regression analysis. P Peduzzi, J Concato, E Kemper, T R Holford, A R FeinsteinJ Clin Epidemiol19968970487Yes
364911811181.026.626.6Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
365011811181.032.432.4Normal bone anatomy and physiology. Bart ClarkeClin J Am Soc Nephrol200818988698No
365111811181.034.834.8Chronic stress, drug use, and vulnerability to addiction. Rajita SinhaAnn N Y Acad Sci200818991954No
365211811181.034.134.1Graves' ophthalmopathy. Rebecca S BahnN Engl J Med201020181974No
365335431181.0113.137.7The Danish National Patient Register. Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka ReboljScand J Public Health201121775347Yes
365411811181.037.637.6Epidemiology of heart failure. Veronique L RogerCirc Res201323989710No
365523611180.564.832.4The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
365611801180.034.334.3Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
365758991179.8166.133.2Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G AltmanPLoS Biol201020613859No
365823581179.062.731.4The diversity and biogeography of soil bacterial communities. Noah Fierer, Robert B JacksonProc Natl Acad Sci U S A200616407148Yes
3659129671178.8424.638.6A global reference for human genetic variation. , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R AbecasisNature201526432245Yes
366023571178.5105.852.9Neurobiology of addiction: a neurocircuitry analysis. George F Koob, Nora D VolkowLancet Psychiatry201627475769No
366111781178.039.339.3Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
366211781178.030.930.9Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Barry HalliwellPlant Physiol200616760481Yes
366311781178.029.729.7The complex world of WNT receptor signalling. Christof NiehrsNat Rev Mol Cell Biol201223151663No
366411781178.060.560.5Cisplatin: The first metal based anticancer drug. Sumit GhoshBioorg Chem201931003078No
366523551177.5166.283.1TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Jan P Meier-Kolthoff, Markus GokerNat Commun201931097708Yes
366611771177.033.833.8Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
366711771177.024.124.1Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
366811771177.028.728.7Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
366911771177.035.335.3Staphylococcus epidermidis--the 'accidental' pathogen. Michael OttoNat Rev Microbiol200919609257No
367011771177.057.457.4Resin composite--state of the art. Jack L FerracaneDent Mater201121093034No
367123541177.090.445.2Shared decision making--pinnacle of patient-centered care. Michael J Barry, Susan Edgman-LevitanN Engl J Med201222375967Yes
367211761176.026.126.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
367323521176.086.843.4Epidemiology of adult fractures: A review. Charles M Court-Brown, Ben CaesarInjury200616814787No
367411761176.043.543.5A polarizing question: do M1 and M2 microglia exist? Richard M RansohoffNat Neurosci201627459405No
367523511175.543.321.6NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
367611751175.011.611.6Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
367711751175.033.933.9Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
367811751175.039.639.6T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. Shane CrottyImmunity201931117010No
367958741174.8113.822.8Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
368035241174.799.633.2AMPK: a nutrient and energy sensor that maintains energy homeostasis. D Grahame Hardie, Fiona A Ross, Simon A HawleyNat Rev Mol Cell Biol201222436748No
368111741174.031.731.7Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
368223481174.067.033.5Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
368311741174.026.226.2The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
368411741174.040.040.0Microbial life in the phyllosphere. Julia A VorholtNat Rev Microbiol201223154261No
368523481174.099.950.0Network analysis: an integrative approach to the structure of psychopathology. Denny Borsboom, Angelique O J CramerAnnu Rev Clin Psychol201323537483No
368611741174.038.738.7The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Peter C AustinStat Med201424122911Yes
368711731173.042.742.7Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
368823461173.059.429.7Molecular mechanisms of T cell co-stimulation and co-inhibition. Lieping Chen, Dallas B FliesNat Rev Immunol201323470321No
368911721172.034.834.8Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
369011721172.051.851.8Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
369123441172.050.425.2Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
369223441172.049.224.6Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
369311721172.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
369411721172.029.429.4Gibberellin metabolism and its regulation. Shinjiro YamaguchiAnnu Rev Plant Biol200818173378No
369535141171.3141.547.2Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
369611711171.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B REXEDJ Comp Neurol195214946260Yes
3697187351170.9688.043.0SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A PevznerJ Comput Biol201222506599Yes
369835121170.7117.139.0The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Stefka Tyanova, Tikira Temu, Juergen CoxNat Protoc201627809316Yes
369923411170.557.028.5Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
370011701170.029.729.7Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
370111701170.021.621.6The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
370211701170.025.425.4What is principal component analysis? Markus RingnerNat Biotechnol200818327243Yes
370323401170.059.029.5Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
370411701170.074.274.2Multicollinearity and misleading statistical results. Jong Hae KimKorean J Anesthesiol201931304696Yes
370535091169.7136.445.5Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
370623391169.547.023.5Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
370723381169.069.734.9Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
370811691169.041.841.8Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
370911691169.031.231.2Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
371011691169.027.327.3Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
371111691169.022.122.1Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
371223381169.046.323.1Fcgamma receptors as regulators of immune responses. Falk Nimmerjahn, Jeffrey V RavetchNat Rev Immunol200818064051No
371335071169.0118.639.5The weirdest people in the world? Joseph Henrich, Steven J Heine, Ara NorenzayanBehav Brain Sci201020550733Yes
371423381169.083.942.0Ferroptosis: Death by Lipid Peroxidation. Wan Seok Yang, Brent R StockwellTrends Cell Biol201626653790No
371523371168.555.927.9An improved general amino acid replacement matrix. Si Quang Le, Olivier GascuelMol Biol Evol200818367465Yes
371611681168.042.742.7View through a window may influence recovery from surgery. R S UlrichScience19846143402Yes
371711681168.035.135.1Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
371811681168.030.430.4Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
371911681168.020.420.4DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
372023361168.056.828.4The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Laetitia Prut, Catherine BelzungEur J Pharmacol200312600700No
372111681168.032.232.2Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
372211671167.024.524.5Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
372335011167.080.426.8Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Vinuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
372411671167.026.626.6Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
372511661166.019.419.4Evolution and tinkering. F JacobScience1977860134Yes
372611661166.00.00.0Knee joint changes after meniscectomy. T J FAIRBANKJ Bone Joint Surg Br194818894618Yes
372746631165.8175.543.9The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. L B Krupp, N G LaRocca, J Muir-Nash, A D SteinbergArch Neurol19892803071Yes
372811651165.031.331.3Leishmaniasis. B L HerwaldtLancet199910513726No
372911651165.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BROWNBiochem J195514389222Yes
373011651165.045.445.4Root canal irrigants. Matthias ZehnderJ Endod200616631834No
373123301165.087.743.9Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Marta Kutas, Kara D FedermeierAnnu Rev Psychol201120809790No
373234941164.7125.942.0Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Michael A Postow, Robert Sidlow, Matthew D HellmannN Engl J Med201829320654No
373311641164.020.620.6Biogenic amines and the states of sleep. M JouvetScience19694303225No
373411641164.024.124.1Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
373511641164.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BULBRINGBr J Pharmacol Chemother194620999334Yes
373623271163.561.530.8The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
373723261163.051.925.9Efficient behavior of small-world networks. V Latora, M MarchioriPhys Rev Lett200111690461Yes
373823261163.050.325.1Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Sharon R Browning, Brian L BrowningAm J Hum Genet200717924348Yes
373911631163.033.333.3Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
374011631163.026.826.8Ab-initio simulations of materials using VASP: Density-functional theory and beyond. Jurgen HafnerJ Comput Chem200818623101Yes
374169761162.7178.629.8Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
374223251162.557.628.8Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NunezNat Rev Immunol201021088683No
374323251162.575.737.9Glycosylation in cancer: mechanisms and clinical implications. Salome S Pinho, Celso A ReisNat Rev Cancer201526289314No
374423251162.5114.057.0Cytokine Storm. David C Fajgenbaum, Carl H JuneN Engl J Med202033264547No
374511621162.021.221.2The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
374669711161.8175.229.2The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
374746471161.8107.927.0C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
374823221161.050.825.4Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
374911611161.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VAGUEAm J Clin Nutr195613282851Yes
375011611161.034.734.7Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
375134831161.0121.340.4IL-6 in inflammation, immunity, and disease. Toshio Tanaka, Masashi Narazaki, Tadamitsu KishimotoCold Spring Harb Perspect Biol201425190079No
375211611161.032.732.7Targeting the DNA Damage Response in Cancer. Mark J O'ConnorMol Cell201526590714No
375323211160.547.723.9Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Javier A Menendez, Ruth LupuNat Rev Cancer200717882277No
375434801160.072.824.3A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
375511601160.037.537.5Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
375611601160.020.920.9Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
375723201160.041.320.6AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
375811601160.039.939.9Development of the practice environment scale of the Nursing Work Index. Eileen T LakeRes Nurs Health200212015780Yes
375911601160.027.127.1Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
376011601160.034.634.6Recommended effect size statistics for repeated measures designs. Roger BakemanBehav Res Methods200516405133Yes
376123191159.566.233.1Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
376223191159.558.829.4Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
376323191159.573.536.8Positive psychology. An introduction. M E Seligman, M CsikszentmihalyiAm Psychol200011392865Yes
376423181159.077.138.5Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudasN Engl J Med19921307234Yes
376511591159.045.345.3Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
376611591159.024.624.6Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
376711591159.00.00.0A new microscopic principle. D GABORNature194818860291Yes
376823181159.066.833.4Genome-wide efficient mixed-model analysis for association studies. Xiang Zhou, Matthew StephensNat Genet201222706312Yes
376923171158.5131.765.8Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W BUTCHER, E W SUTHERLANDJ Biol Chem196213875173Yes
377023161158.070.135.0Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
377123161158.053.426.7Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
377211581158.022.922.9Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
377311581158.030.530.5A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
377434741158.077.025.7STATs in cancer inflammation and immunity: a leading role for STAT3. Hua Yu, Drew Pardoll, Richard JoveNat Rev Cancer200919851315No
377511571157.030.930.9Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
377611571157.028.128.1Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
377711571157.024.024.0Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
377811571157.032.332.3Conceptual synthesis in community ecology. Mark VellendQ Rev Biol201020565040No
377911571157.071.471.4Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. Cheng-Hsien LiBehav Res Methods201626174714Yes
378034701156.782.027.3Pathogenic Escherichia coli. James B Kaper, James P Nataro, Harry L MobleyNat Rev Microbiol200415040260No
378123131156.549.124.6Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
378223131156.545.322.6Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
378334691156.3101.233.7Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
378434681156.083.727.9High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
378523121156.092.346.1The aggression questionnaire. A H Buss, M PerryJ Pers Soc Psychol19921403624Yes
378611561156.024.324.3RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
378711561156.044.444.4Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
378811561156.031.531.5Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. A E BlackInt J Obes Relat Metab Disord200011033980Yes
378911561156.028.928.9Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
379057801156.0197.439.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, Open Med200921603045Yes
379123101155.060.430.2Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
379223101155.066.933.5Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
379311551155.026.326.3Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
379411551155.036.936.9Subjective well-being. The science of happiness and a proposal for a national index. E DienerAm Psychol200011392863Yes
379511551155.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VANEBr J Pharmacol Chemother195713460242Yes
379611551155.024.424.4Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
379711551155.00.00.0The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. C D MurrayProc Natl Acad Sci U S A192616576980Yes
379811551155.044.544.5Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. Peter J BarnesJ Allergy Clin Immunol201627373322No
379911551155.027.627.6Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
380023091154.557.028.5Monocyte recruitment during infection and inflammation. Chao Shi, Eric G PamerNat Rev Immunol201121984070No
380169241154.0187.231.2Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
380211541154.028.628.6Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
380311541154.038.138.1A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
380411541154.027.127.1Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
3805207681153.8489.527.2PHENIX: a comprehensive Python-based system for macromolecular structure solution. Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H ZwartActa Crystallogr D Biol Crystallogr201020124702Yes
380634611153.787.829.3Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
380723061153.046.023.0A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
380811531153.033.433.4Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
380911531153.023.223.2Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
381011531153.020.520.5Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
381111531153.024.124.1Pyramidal neurons: dendritic structure and synaptic integration. Nelson SprustonNat Rev Neurosci200818270515No
381223041152.046.823.4Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
381311521152.040.840.8Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
381411521152.032.432.4Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
381511521152.023.923.9Stem cells in the central nervous system. R McKayScience19979082987No
381611521152.020.220.2The development of neural stem cells. S TempleNature200111689956No
381723041152.053.726.9Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkBioinformatics200717050570Yes
381811521152.047.247.2How Many Subjects Does It Take To Do A Regression Analysis. S B GreenMultivariate Behav Res199126776715Yes
381923031151.548.524.2Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
382011511151.032.532.5Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
382111511151.025.325.3Pathogenesis of atherosclerosis. Erling FalkJ Am Coll Cardiol200616631513Yes
382223011150.564.732.4Extended-spectrum beta-lactamases: a clinical update. David L Paterson, Robert A BonomoClin Microbiol Rev200516223952No
382311501150.021.721.7Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
382411501150.029.529.5Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
382523001150.00.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C TRUELOVE, L J WITTSBr Med J195513260656Yes
382611501150.024.124.1The action potential in mammalian central neurons. Bruce P BeanNat Rev Neurosci200717514198No
382746001150.098.024.5Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled ClaytonCurr Protoc Cell Biol200618228490Yes
382811501150.041.541.5Surface-enhanced Raman spectroscopy: concepts and chemical applications. Sebastian SchluckerAngew Chem Int Ed Engl201424711218Yes
382911501150.043.843.8Epithelial Mesenchymal Transition in Tumor Metastasis. Vivek MittalAnnu Rev Pathol201829414248No
383011491149.031.931.9DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
383122981149.058.429.2Cu-catalyzed azide-alkyne cycloaddition. Morten Meldal, Christian Wenzel TornoeChem Rev200818698735No
383211491149.024.024.0Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
383357441148.8224.344.9MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah LamBioinformatics201525609793Yes
383422971148.544.422.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
383545941148.534.18.5The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLMELancet196313990765Yes
383611481148.021.521.5Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
383711481148.034.334.3Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
383811481148.031.331.3Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
383911481148.026.226.2BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
384011481148.026.626.6Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
384111481148.032.232.2Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
384211481148.037.937.9Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Murray B IsmanAnnu Rev Entomol200616332203No
384311481148.029.029.0Electrogenerated chemiluminescence and its biorelated applications. Wujian MiaoChem Rev200818505298No
384445911147.8109.327.3Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
384545911147.8202.650.6Random effects structure for confirmatory hypothesis testing: Keep it maximal. Dale J Barr, Roger Levy, Christoph Scheepers, Harry J TilyJ Mem Lang201324403724Yes
384622951147.585.943.0Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
384722951147.559.229.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
384811471147.021.721.7Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
384922941147.045.322.6A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
385011471147.032.432.4The social brain in adolescence. Sarah-Jayne BlakemoreNat Rev Neurosci200818354399No
385111471147.043.843.8Reference methods for the assessment of physical characteristics of meat. K O HonikelMeat Sci199822060626Yes
385211471147.034.334.3The enteric nervous system and neurogastroenterology. John B FurnessNat Rev Gastroenterol Hepatol201222392290No
385345871146.8146.236.5The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
385422931146.588.644.3Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
385511461146.033.033.0Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
385657291145.8281.156.2UFBoot2: Improving the Ultrafast Bootstrap Approximation. Diep Thi Hoang, Olga Chernomor, Arndt von Haeseler, Bui Quang Minh, Le Sy VinhMol Biol Evol201829077904Yes
385780201145.7136.119.4The human genome browser at UCSC. W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David HausslerGenome Res200212045153Yes
385834351145.090.930.3Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
385911451145.027.227.2Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
386011451145.029.729.7Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
386122901145.00.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H USSING, K ZERAHNActa Physiol Scand195114868510Yes
386234341144.781.127.0In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Chun-Chi Liang, Ann Y Park, Jun-Lin GuanNat Protoc200717406593Yes
386311441144.028.528.5Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
386411441144.020.620.6Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
386522881144.055.627.8Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
386611441144.022.822.8Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
386711441144.045.445.4Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Hannah R SnyderPsychol Bull201322642228No
386822871143.541.120.6Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
386911431143.043.643.6Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
387011431143.033.733.7Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
387111431143.031.931.9An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
387211431143.023.223.2The mitochondrial genome: structure, transcription, translation and replication. J W TaanmanBiochim Biophys Acta199910076021No
387311431143.023.623.6Complement. Second of two parts. M J WalportN Engl J Med200111297706No
387411431143.026.126.1Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
387534281142.7110.236.7Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
387622851142.554.427.2The neural basis of decision making. Joshua I Gold, Michael N ShadlenAnnu Rev Neurosci200717600525No
387722841142.072.336.1Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
387822841142.052.726.4A note on quantifying follow-up in studies of failure time. M Schemper, T L SmithControl Clin Trials19968889347Yes
387911421142.017.017.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EGEBERGThromb Diath Haemorrh196514347873Yes
388022841142.063.431.7Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
388111421142.032.732.7The broaden-and-build theory of positive emotions. Barbara L FredricksonPhilos Trans R Soc Lond B Biol Sci200415347528No
388211411141.034.534.5Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
388311411141.018.618.6The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
388411411141.027.227.2The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
388522821141.0137.468.7Modified reagents for determination of urea and ammonia. A L CHANEY, E P MARBACHClin Chem196213878063Yes
388611411141.068.268.2Diffusion-in-gel methods for immunological analysis. II. O OUCHTERLONYProg Allergy196214482809Yes
388711411141.021.621.6Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
388822811140.563.031.5ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
388911401140.027.127.1The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. G HardinScience19685699198Yes
389034201140.064.621.5Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
389111401140.027.127.1The role of acetylcholine in learning and memory. Michael E HasselmoCurr Opin Neurobiol200617011181No
389211401140.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HOTCHKISSArch Biochem194818921848Yes
389322791139.588.244.1Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
389422781139.059.429.7Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassagueJ Biol Chem19863456347Yes
389522781139.065.732.9Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. R J Ginsberg, L V RubinsteinAnn Thorac Surg19957677489Yes
389611391139.037.737.7A measure of anxiety symptoms among children. S H SpenceBehav Res Ther19989648330Yes
389711391139.016.316.3Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PENNINGTONBiochem J196113734134Yes
389822771138.585.442.7Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
389911381138.081.481.4Fibula free flap: a new method of mandible reconstruction. D A HidalgoPlast Reconstr Surg19892734406Yes
390011381138.027.627.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
390111381138.025.025.0Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
390245521138.0103.926.0SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
390311381138.025.825.8Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
390411381138.027.127.1Omega-3 fatty acids in inflammation and autoimmune diseases. Artemis P SimopoulosJ Am Coll Nutr200212480795No
390511381138.025.825.8Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WurthnerChem Commun (Camb)200415263926Yes
390611381138.025.225.2Mucins in cancer: function, prognosis and therapy. Donald W KufeNat Rev Cancer200919935676No
390722761138.082.241.1The blood-brain barrier. Richard Daneman, Alexandre PratCold Spring Harb Perspect Biol201525561720No
390822751137.570.535.2Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
390911371137.039.939.9Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
391011371137.022.622.6Alpha-synuclein and neurodegenerative diseases. M GoedertNat Rev Neurosci200111433374No
391111371137.020.920.9Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
391222731136.5123.661.8miRDB: an online database for prediction of functional microRNA targets. Yuhao Chen, Xiaowei WangNucleic Acids Res202031504780Yes
391311361136.055.455.4The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
391411361136.019.219.25-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Judith K ChristmanOncogene200212154409No
391511361136.00.00.0The stereotaxic method and radiosurgery of the brain. L LEKSELLActa Chir Scand195114914373Yes
391611361136.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
391756791135.8150.130.0A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo PandolfiCell201121802130Yes
391811351135.034.634.6Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
391911351135.025.225.2Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
392011351135.027.427.4Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
392111351135.00.00.0pA, a new scale for the measurement of drug antagonism. H O SCHILDBr J Pharmacol Chemother194720258355Yes
392256731134.6200.540.1A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
392322691134.563.831.9Neural regulation of endocrine and autonomic stress responses. Yvonne M Ulrich-Lai, James P HermanNat Rev Neurosci200919469025No
392422691134.579.839.9Perceived discrimination and health: a meta-analytic review. Elizabeth A Pascoe, Laura Smart RichmanPsychol Bull200919586161Yes
392511341134.069.069.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
392611341134.020.220.2Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
392734021134.093.131.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
392811341134.00.00.0Motivation reconsidered: the concept of competence. R W WHITEPsychol Rev195913844397Yes
392922661133.056.028.0A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
393011331133.031.331.3Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
393133991133.072.624.2Mitochondria, oxidants, and aging. Robert S Balaban, Shino Nemoto, Toren FinkelCell200515734681No
393211321132.034.534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
393311321132.011.611.6Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. J J HopfieldProc Natl Acad Sci U S A19744530290Yes
393411321132.033.233.2Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
393511321132.026.826.8Soil carbon sequestration impacts on global climate change and food security. R LalScience200415192216Yes
393611321132.028.528.5Descending pathways in motor control. Roger N LemonAnnu Rev Neurosci200818558853No
393711321132.027.327.3Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Richard M CawthonNucleic Acids Res200919129229Yes
393822631131.553.226.6T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
393911311131.042.942.9On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
394022611130.545.122.6RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
394122611130.599.149.5Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
3942135621130.2402.233.5Ferroptosis: an iron-dependent form of nonapoptotic cell death. Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang, Barclay Morrison, Brent R StockwellCell201222632970Yes
394311301130.039.839.8Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
394411301130.023.523.5Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
394511301130.040.940.9An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. F G HappeJ Autism Dev Disord19948040158Yes
394611301130.020.420.4Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
394745201130.0155.939.0Development of recommendations for SEMG sensors and sensor placement procedures. H J Hermens, B Freriks, C Disselhorst-Klug, G RauJ Electromyogr Kinesiol200011018445Yes
394811301130.024.024.0The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
394911291129.028.628.6Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
395011291129.032.232.2Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
395111291129.027.927.9Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
395222581129.052.226.1The oxytocin receptor system: structure, function, and regulation. G Gimpl, F FahrenholzPhysiol Rev200111274341No
395311291129.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EASTERBROOKPsychol Rev195913658305Yes
395411291129.027.027.0Hybridization as an invasion of the genome. James MalletTrends Ecol Evol200516701374Yes
395511291129.030.130.1Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
395611291129.035.635.6Biomedical photoacoustic imaging. Paul BeardInterface Focus201122866233Yes
395711281128.027.927.9Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
395811281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B STAVITSKYJ Immunol195413163409Yes
395911281128.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DEESEJ Exp Psychol195913664879Yes
396011281128.024.924.9The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
396111281128.025.825.8NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Weihai YingAntioxid Redox Signal200818020963No
396233831127.7119.539.8Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
3963112761127.6394.239.4The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherPLoS Med200919621070No
396422551127.536.418.2Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
396522541127.095.547.8Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
396611271127.026.626.6Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
396745081127.084.821.2DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
396811271127.024.524.5Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
396922541127.052.826.4The NF-kappaB family of transcription factors and its regulation. Andrea Oeckinghaus, Sankar GhoshCold Spring Harb Perspect Biol200920066092No
397011271127.030.130.1Voltage-gated calcium channels. William A CatterallCold Spring Harb Perspect Biol201121746798No
397111271127.042.642.6A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
397222541127.0112.756.4The neuropathological diagnosis of Alzheimer's disease. Michael A DeTure, Dennis W DicksonMol Neurodegener201931375134No
397311271127.088.188.1Complex heatmap visualization. Zuguang GuImeta202238868715Yes
397411261126.039.739.7Perceptual selectivity for color and form. J TheeuwesPercept Psychophys19921620571No
397511261126.027.827.8The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
397622521126.048.724.4Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
397711261126.021.721.7Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
397811261126.036.936.9Supramolecular binding thermodynamics by dispersion-corrected density functional theory. Stefan GrimmeChemistry201222782805Yes
397933781126.0105.835.3xCell: digitally portraying the tissue cellular heterogeneity landscape. Dvir Aran, Zicheng Hu, Atul J ButteGenome Biol201729141660Yes
398011251125.049.449.4Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
398111251125.033.933.9Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
398211251125.036.536.5Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
398311251125.023.123.1Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
398411251125.021.221.2Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
398511251125.024.024.0New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
398611251125.018.518.5Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
398711251125.026.226.2Area deprivation and widening inequalities in US mortality, 1969-1998. Gopal K SinghAm J Public Health200312835199Yes
398822501125.076.838.4Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Louise C Hawkley, John T CacioppoAnn Behav Med201020652462No
398922501125.0162.781.3Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Fangda Leng, Paul EdisonNat Rev Neurol202133318676No
399011251125.0242.0242.0ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns. Malik SallamHealthcare (Basel)202336981544No
399122491124.546.823.4InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
399211241124.055.555.5The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
399311241124.035.735.7Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
399411241124.033.033.0Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
399511241124.030.230.2Innate immunity of fish (overview). Bergljot MagnadottirFish Shellfish Immunol200615950491No
399644941123.5180.145.0From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik BackhedCell201627259147No
399711231123.041.441.4Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
399811231123.027.127.1Biological effects of resveratrol. L FremontLife Sci200010680575No
399911231123.032.832.8The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. R CharonJAMA200111597295Yes
400011231123.025.325.3P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
400111231123.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B REXEDJ Comp Neurol195413163236Yes
400211231123.035.535.5Mental illness and/or mental health? Investigating axioms of the complete state model of health. Corey L M KeyesJ Consult Clin Psychol200515982151Yes
400322461123.062.331.1Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
400411231123.038.438.4Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. Gyorgy BuzsakiHippocampus201526135716No
400544911122.8115.128.8Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
400622451122.553.526.8Inflammatory bowel disease. Clara Abraham, Judy H ChoN Engl J Med200919923578No
400744901122.5119.729.9A role for mitochondria in NLRP3 inflammasome activation. Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg TschoppNature201121124315Yes
400844891122.2135.733.9Causal analysis approaches in Ingenuity Pathway Analysis. Andreas Kramer, Jeff Green, Jack Pollard, Stuart TugendreichBioinformatics201424336805Yes
400911221122.029.629.6The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
401022441122.083.541.8The structure of psychological well-being revisited. C D Ryff, C L KeyesJ Pers Soc Psychol19957473027Yes
401111221122.036.536.5Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
401211221122.023.223.2ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
401311221122.032.232.2Image matching as a diffusion process: an analogy with Maxwell's demons. J P ThirionMed Image Anal19989873902Yes
401411221122.032.732.7Spontaneous dissection of the carotid and vertebral arteries. W I SchievinkN Engl J Med200111259724No
401511221122.041.941.9Fiber and prebiotics: mechanisms and health benefits. Joanne SlavinNutrients201323609775No
401622431121.580.040.0NAFLD: a multisystem disease. Christopher D Byrne, Giovanni TargherJ Hepatol201525920090No
401711211121.025.925.9The emotional brain, fear, and the amygdala. Joseph LeDouxCell Mol Neurobiol200314514027No
401811211121.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SPERRYJ Comp Physiol Psychol195014794830Yes
401911211121.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
402022421121.070.835.4Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Lance W Peterson, David ArtisNat Rev Immunol201424566914No
402111211121.048.948.9Psychedelics. David E NicholsPharmacol Rev201626841800No
402222411120.555.327.6A general purpose model for the condensed phases of water: TIP4P/2005. J L F Abascal, C VegaJ Chem Phys200516392929Yes
402311201120.030.630.6Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
402422401120.052.426.2Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie Beral, Lancet200312927427Yes
402511201120.026.326.3Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
402622391119.561.830.9Flexible regression models with cubic splines. S Durrleman, R SimonStat Med19892657958Yes
402722391119.546.623.3Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. P J Roberts, C J DerOncogene200717496923No
402867161119.3150.125.0Alpha-synuclein in Lewy bodies. M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M GoedertNature19979278044Yes
402922381119.066.033.0A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
403011191119.037.137.1Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
403122381119.065.432.7Stool form scale as a useful guide to intestinal transit time. S J Lewis, K W HeatonScand J Gastroenterol19979299672Yes
403211191119.022.522.5The muscular dystrophies. Alan E H EmeryLancet200211879882No
403311191119.020.620.6mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
403422381119.049.324.6How to interpret LC3 immunoblotting. Noboru Mizushima, Tamotsu YoshimoriAutophagy200717611390No
403511191119.031.431.4Cytochrome p450 and chemical toxicology. F Peter GuengerichChem Res Toxicol200818052394No
403611191119.071.771.7Antimicrobial Resistance: Implications and Costs. Porooshat DadgostarInfect Drug Resist201931908502No
403722371118.554.327.1Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
403822361118.0108.854.4Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
403911181118.028.228.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
404011181118.031.731.7Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
404111181118.029.629.6Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
404222361118.045.822.9An energy budget for signaling in the grey matter of the brain. D Attwell, S B LaughlinJ Cereb Blood Flow Metab200111598490No
404311181118.032.032.0Outer membrane permeability and antibiotic resistance. Anne H DelcourBiochim Biophys Acta200919100346No
404411181118.047.647.6Fibromyalgia: a clinical review. Daniel J ClauwJAMA201424737367No
404533531117.7134.244.7A new method for detecting anaerobic threshold by gas exchange. W L Beaver, K Wasserman, B J WhippJ Appl Physiol (1985)19863087938Yes
404644701117.5139.935.0Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
404722341117.032.216.1Microdroplet Assay Of Human Serum Cytotoxins. P I TERASAKI, J D MCCLELLANDNature196414248725Yes
404822341117.026.513.2Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P GOLD, S O FREEDMANJ Exp Med196514270243Yes
404911171117.023.323.3The self-tuning neuron: synaptic scaling of excitatory synapses. Gina G TurrigianoCell200818984155No
405033491116.391.930.6Foreign body reaction to biomaterials. James M Anderson, Analiz Rodriguez, David T ChangSemin Immunol200818162407No
405122321116.044.022.0In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KarreImmunol Today19902201309No
405211161116.034.934.9Vitamin D status: measurement, interpretation, and clinical application. Michael F HolickAnn Epidemiol200918329892No
405333471115.7109.936.6A new rating scale for Alzheimer's disease. W G Rosen, R C Mohs, K L DavisAm J Psychiatry19846496779Yes
405422311115.554.527.2Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. D Rice, S BaroneEnviron Health Perspect200010852851No
405511151115.013.313.3Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
405611151115.036.836.8Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
405744601115.0113.428.4A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
405811151115.021.121.1The evolutionary significance of cis-regulatory mutations. Gregory A WrayNat Rev Genet200717304246No
405911151115.056.056.0COVID-19: immunopathology and its implications for therapy. Xuetao CaoNat Rev Immunol202032273594Yes
4060144871114.4378.729.1The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , JAMA200312748199No
406144571114.2102.325.6The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
406211141114.023.223.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
406311141114.013.913.9The evolutionary advantage of recombination. J FelsensteinGenetics19744448362Yes
406422281114.056.628.3Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. L Pellerin, P J MagistrettiProc Natl Acad Sci U S A19947938003Yes
406522281114.045.722.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
406611141114.020.520.5Cytokines in cancer pathogenesis and cancer therapy. Glenn DranoffNat Rev Cancer200414708024No
406722281114.060.230.1The spread of obesity in a large social network over 32 years. Nicholas A Christakis, James H FowlerN Engl J Med200717652652Yes
406811141114.0146.8146.8Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. Shifu ChenImeta202338868435Yes
406944551113.8108.327.1An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
407022271113.553.626.8The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
407122271113.569.534.8Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
407244541113.5113.728.4REVIGO summarizes and visualizes long lists of gene ontology terms. Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav SmucPLoS One201121789182Yes
407311131113.062.062.0The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
407411131113.028.028.0Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
407511131113.021.621.6Unfolding the role of protein misfolding in neurodegenerative diseases. Claudio SotoNat Rev Neurosci200312511861No
407611131113.022.722.7Large-scale recording of neuronal ensembles. Gyorgy BuzsakiNat Neurosci200415114356No
407711131113.023.023.0The molecular biology of coronaviruses. Paul S MastersAdv Virus Res200616877062No
407822261113.053.726.9Recent developments in the MAFFT multiple sequence alignment program. Kazutaka Katoh, Hiroyuki TohBrief Bioinform200818372315Yes
407922251112.590.845.4The social determinants of health: it's time to consider the causes of the causes. Paula Braveman, Laura GottliebPublic Health Rep201424385661No
408044491112.2109.227.3Wound repair and regeneration. Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T LongakerNature200818480812No
408111121112.045.545.5Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
408244481112.0149.337.3Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
408311121112.022.422.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
408422241112.058.729.4The cerebellar cognitive affective syndrome. J D Schmahmann, J C ShermanBrain19989577385Yes
408511121112.021.621.6Automated NMR structure calculation with CYANA. Peter GuntertMethods Mol Biol200415318003Yes
408611121112.023.123.1Evolution of the neocortex: a perspective from developmental biology. Pasko RakicNat Rev Neurosci200919763105No
408711121112.044.844.8The epidemiology and impact of pain in osteoarthritis. T NeogiOsteoarthritis Cartilage201323973124Yes
408811111111.022.222.2Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
408911111111.021.721.7Cytokine receptor signalling. J N IhleNature19957566171No
409011111111.025.525.5Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
409111111111.030.930.9Lanthanide-based luminescent hybrid materials. Koen BinnemansChem Rev200919650663Yes
409222221111.058.429.2DNA methylation: roles in mammalian development. Zachary D Smith, Alexander MeissnerNat Rev Genet201323400093No
409322211110.577.438.7Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
409422211110.549.124.6Mechanisms of endocytosis. Gary J Doherty, Harvey T McMahonAnnu Rev Biochem200919317650No
409511101110.041.541.5Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
409611101110.023.823.8A cortical-hippocampal system for declarative memory. H EichenbaumNat Rev Neurosci200011252767No
409733291109.7108.736.2Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
409822191109.564.932.5Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
409911091109.025.825.8A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
410022181109.038.219.1Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
410111091109.032.532.5The Delphi technique: myths and realities. Catherine PowellJ Adv Nurs200312581103No
410211091109.027.427.4Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Jill E ClarridgeClin Microbiol Rev200415489351No
410322171108.560.030.0Collagen structure and stability. Matthew D Shoulders, Ronald T RainesAnnu Rev Biochem200919344236No
410411081108.032.732.7Comparing evolvability and variability of quantitative traits. D HouleGenetics19921732160Yes
410511081108.00.00.0Asymptomatic infections of the urinary tract. E H KASSTrans Assoc Am Physicians195613380946Yes
410622151107.547.723.9p21 in cancer: intricate networks and multiple activities. Tarek Abbas, Anindya DuttaNat Rev Cancer200919440234No
410755371107.4115.123.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
410811071107.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TEALEBiochim Biophys Acta195913837237Yes
410911071107.026.026.0Trypan blue exclusion test of cell viability. W StroberCurr Protoc Immunol200118432654Yes
411044271106.8158.939.7Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
411122131106.593.746.9Biological Functions of Autophagy Genes: A Disease Perspective. Beth Levine, Guido KroemerCell201930633901No
411222121106.071.735.9Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
411366361106.0164.427.4Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
411422121106.00.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H COONS, M H KAPLANJ Exp Med195015395569Yes
411511061106.027.827.8Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. Paul H YanceyJ Exp Biol200516043587No
411611061106.043.643.6Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Philip C CalderBiochim Biophys Acta201525149823No
411777411105.9662.394.6The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James RubinLancet202032112714No
411822111105.548.624.3Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
411911051105.026.626.6Sleep-dependent memory consolidation. Robert StickgoldNature200516251952No
412022091104.589.844.9Emotional processing of fear: exposure to corrective information. E B Foa, M J KozakPsychol Bull19862871574Yes
412122091104.552.126.1CpG islands and the regulation of transcription. Aimee M Deaton, Adrian BirdGenes Dev201121576262No
412211041104.022.122.1Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
412322081104.065.432.72,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
412411041104.029.829.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
412511041104.021.621.6Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
412611041104.018.318.3The concept of synthetic lethality in the context of anticancer therapy. William G KaelinNat Rev Cancer200516110319No
412711041104.037.037.0The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. James A ImlayNat Rev Microbiol201323712352No
412822071103.549.224.6Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
412922071103.585.142.5Mechanism and medical implications of mammalian autophagy. Ivan Dikic, Zvulun ElazarNat Rev Mol Cell Biol201829618831No
413011031103.022.922.9Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
413122061103.087.043.5Global estimates of visual impairment: 2010. Donatella Pascolini, Silvio Paolo MariottiBr J Ophthalmol201222133988Yes
413211031103.033.533.5Molecular pathogenesis and mechanisms of thyroid cancer. Mingzhao XingNat Rev Cancer201323429735No
413333081102.7139.946.6Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. Neil M Davies, Michael V Holmes, George Davey SmithBMJ201830002074Yes
413422051102.564.432.2Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
413522051102.545.022.5p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
413644101102.5119.930.0voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Charity W Law, Yunshun Chen, Wei Shi, Gordon K SmythGenome Biol201424485249Yes
413722051102.576.738.4Coronaviruses: an overview of their replication and pathogenesis. Anthony R Fehr, Stanley PerlmanMethods Mol Biol201525720466No
413811021102.037.637.6A theory of visual attention. C BundesenPsychol Rev19902247540Yes
413911021102.020.620.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
414011021102.024.124.1The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
414111021102.025.225.2Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
414211021102.024.924.9Marine viruses and their biogeochemical and ecological effects. J A FuhrmanNature199910376593No
414322031101.546.523.2Glycosylation in cellular mechanisms of health and disease. Kazuaki Ohtsubo, Jamey D MarthCell200616959566No
414422031101.557.228.6Reactive oxygen species in cancer. Geou-Yarh Liou, Peter StorzFree Radic Res201020370557No
414522031101.565.933.0The human microbiome: at the interface of health and disease. Ilseung Cho, Martin J BlaserNat Rev Genet201222411464No
414611011101.026.926.9Avidin. N M GreenAdv Protein Chem1975237414Yes
414711011101.019.019.0Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
414811011101.041.941.9The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
414911011101.033.833.8The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
415022021101.070.235.1Required sample size to detect the mediated effect. Matthew S Fritz, David P MackinnonPsychol Sci200717444920Yes
415111011101.034.934.9Designing cell-compatible hydrogels for biomedical applications. Dror SeliktarScience201222654050No
415233021100.799.233.1DNA methylation and its basic function. Lisa D Moore, Thuc Le, Guoping FanNeuropsychopharmacology201322781841No
415322001100.063.231.6The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
415411001100.023.823.8Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
415511001100.024.724.7The primate basal ganglia: parallel and integrative networks. Suzanne N HaberJ Chem Neuroanat200314729134No
415633001100.079.626.5Stress and the brain: from adaptation to disease. E Ron de Kloet, Marian Joels, Florian HolsboerNat Rev Neurosci200515891777No
415722001100.056.628.3Delivering nanomedicine to solid tumors. Rakesh K Jain, Triantafyllos StylianopoulosNat Rev Clin Oncol201020838415No
415854991099.8139.828.010-year follow-up of intensive glucose control in type 2 diabetes. Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W NeilN Engl J Med200818784090Yes
415921991099.50.00.0Micromethod for the direct determination of serum triglycerides. E VAN HANDEL, D B ZILVERSMITJ Lab Clin Med195713439279Yes
416021991099.564.432.2Exploring the brain network: a review on resting-state fMRI functional connectivity. Martijn P van den Heuvel, Hilleke E Hulshoff PolEur Neuropsychopharmacol201020471808No
416121981099.055.927.9How should meta-regression analyses be undertaken and interpreted? Simon G Thompson, Julian P T HigginsStat Med200212111920Yes
416210991099.023.723.7Immunosuppressive drugs for kidney transplantation. Philip F HalloranN Engl J Med200415616206No
416310991099.034.534.5Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
416410981098.018.818.8Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
416510981098.032.532.5Topography of cognition: parallel distributed networks in primate association cortex. P S Goldman-RakicAnnu Rev Neurosci19883284439No
416621961098.034.817.4Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
416710981098.020.120.1Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
416821961098.069.834.9Plant polyphenols as dietary antioxidants in human health and disease. Kanti Bhooshan Pandey, Syed Ibrahim RizviOxid Med Cell Longev200920716914No
416998811097.9304.333.8Robust enumeration of cell subsets from tissue expression profiles. Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A AlizadehNat Methods201525822800Yes
417032931097.7104.734.9The triple aim: care, health, and cost. Donald M Berwick, Thomas W Nolan, John WhittingtonHealth Aff (Millwood)200818474969Yes
417121951097.544.422.2GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. Sean Davis, Paul S MeltzerBioinformatics200717496320Yes
417221941097.068.134.0Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
417310971097.032.132.1The phylogenetic regression. A GrafenPhilos Trans R Soc Lond B Biol Sci19892575770Yes
417410971097.020.620.6Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
417521941097.0102.951.5Development, reliability, and validity of a dissociation scale. E M Bernstein, F W PutnamJ Nerv Ment Dis19863783140Yes
417610971097.027.027.0Forests and climate change: forcings, feedbacks, and the climate benefits of forests. Gordon B BonanScience200818556546No

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