Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 4075 papers with ECcit ≥ 1073.7
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 60, August 2025
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 225766 | 225766.0 | 4687.1 | 4687.1 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 179017 | 179017.0 | 7119.3 | 7119.3 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 287966 | 71991.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 134621 | 67310.5 | 3304.2 | 1652.1 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 46432 | 46432.0 | 1378.2 | 1378.2 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 38254 | 38254.0 | 1231.1 | 1231.1 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64688 | 32344.0 | 1932.0 | 966.0 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30249 | 30249.0 | 822.4 | 822.4 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 29053 | 29053.0 | 915.2 | 915.2 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 10 | 29049 | 29049.0 | 675.3 | 675.3 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 11 | 28759 | 28759.0 | 623.4 | 623.4 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | False |
| 12 | 27225 | 27225.0 | 695.9 | 695.9 | A rating scale for depression. | M HAMILTON | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 25997 | 25997.0 | 589.7 | 589.7 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 25323 | 25323.0 | 789.6 | 789.6 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 46464 | 23232.0 | 1383.6 | 691.8 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | False |
| 16 | 69070 | 23023.3 | 2521.0 | 840.3 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 17 | 22377 | 22377.0 | 610.9 | 610.9 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 18 | 66289 | 22096.3 | 1642.2 | 547.4 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 19 | 21561 | 21561.0 | 731.3 | 731.3 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 41503 | 20751.5 | 1281.0 | 640.5 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 21 | 20419 | 20419.0 | 240.8 | 240.8 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J Cell Biol | 1963 | 13986422 | Yes |
| 22 | 20251 | 20251.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 23 | 39082 | 19541.0 | 1600.4 | 800.2 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 24 | 58098 | 19366.0 | 2041.4 | 680.5 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 25 | 19111 | 19111.0 | 757.7 | 757.7 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 26 | 37729 | 18864.5 | 1761.0 | 880.5 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 27 | 54679 | 18226.3 | 1593.1 | 531.0 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 28 | 36448 | 18224.0 | 1102.9 | 551.5 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 29 | 18185 | 18185.0 | 670.0 | 670.0 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 30 | 18036 | 18036.0 | 737.5 | 737.5 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 31 | 53599 | 17866.3 | 2030.0 | 676.7 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 32 | 17250 | 17250.0 | 427.9 | 427.9 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | False |
| 33 | 34263 | 17131.5 | 840.8 | 420.4 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 34 | 16765 | 16765.0 | 283.2 | 283.2 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J DAVIS | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 35 | 33430 | 16715.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 36 | 32680 | 16340.0 | 1292.8 | 646.4 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 37 | 16328 | 16328.0 | 759.9 | 759.9 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 38 | 16222 | 16222.0 | 449.1 | 449.1 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 39 | 15998 | 15998.0 | 388.8 | 388.8 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | False |
| 40 | 15934 | 15934.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem J | 1956 | 13293190 | Yes |
| 41 | 31544 | 15772.0 | 1173.3 | 586.6 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 42 | 15632 | 15632.0 | 602.8 | 602.8 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 43 | 46135 | 15378.3 | 1310.0 | 436.7 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 44 | 30445 | 15222.5 | 821.5 | 410.8 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 45 | 43044 | 14348.0 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J Biol Chem | 1957 | 13428781 | Yes |
| 46 | 13588 | 13588.0 | 333.3 | 333.3 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 47 | 13579 | 13579.0 | 516.0 | 516.0 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 48 | 40562 | 13520.7 | 1484.6 | 494.9 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 49 | 26879 | 13439.5 | 543.4 | 271.7 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 50 | 66795 | 13359.0 | 1910.9 | 382.2 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 51 | 26443 | 13221.5 | 704.7 | 352.4 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 52 | 13170 | 13170.0 | 599.0 | 599.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 53 | 13169 | 13169.0 | 403.7 | 403.7 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 54 | 26110 | 13055.0 | 1056.1 | 528.0 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 55 | 13037 | 13037.0 | 436.3 | 436.3 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 56 | 13000 | 13000.0 | 389.0 | 389.0 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 57 | 38801 | 12933.7 | 1349.2 | 449.7 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 58 | 25546 | 12773.0 | 926.2 | 463.1 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 59 | 12656 | 12656.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J Biol Chem | 1959 | 13641241 | Yes |
| 60 | 12652 | 12652.0 | 146.3 | 146.3 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 61 | 12357 | 12357.0 | 404.8 | 404.8 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 62 | 24467 | 12233.5 | 520.9 | 260.4 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 63 | 36653 | 12217.7 | 947.9 | 316.0 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 64 | 24071 | 12035.5 | 518.7 | 259.4 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 65 | 35879 | 11959.7 | 1152.8 | 384.3 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | False |
| 66 | 11900 | 11900.0 | 502.6 | 502.6 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 67 | 11855 | 11855.0 | 446.4 | 446.4 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 68 | 45512 | 11378.0 | 1278.6 | 319.6 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | False |
| 69 | 21983 | 10991.5 | 922.6 | 461.3 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 70 | 10874 | 10874.0 | 496.2 | 496.2 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 71 | 10797 | 10797.0 | 356.5 | 356.5 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 72 | 10787 | 10787.0 | 275.4 | 275.4 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 73 | 21557 | 10778.5 | 555.8 | 277.9 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 74 | 10538 | 10538.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 75 | 10330 | 10330.0 | 436.5 | 436.5 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 76 | 10302 | 10302.0 | 201.3 | 201.3 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 77 | 10171 | 10171.0 | 281.5 | 281.5 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | False |
| 78 | 10133 | 10133.0 | 286.6 | 286.6 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 79 | 40021 | 10005.2 | 1452.8 | 363.2 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 80 | 9971 | 9971.0 | 202.9 | 202.9 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 81 | 19814 | 9907.0 | 356.4 | 178.2 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 82 | 39303 | 9825.8 | 1259.4 | 314.9 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 83 | 9726 | 9726.0 | 272.3 | 272.3 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | False |
| 84 | 19336 | 9668.0 | 495.9 | 247.9 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 85 | 19254 | 9627.0 | 492.9 | 246.4 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 86 | 9612 | 9612.0 | 226.7 | 226.7 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 87 | 28790 | 9596.7 | 831.4 | 277.1 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 88 | 9593 | 9593.0 | 317.1 | 317.1 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | False |
| 89 | 28760 | 9586.7 | 737.4 | 245.8 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 90 | 9540 | 9540.0 | 241.8 | 241.8 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 91 | 9504 | 9504.0 | 245.7 | 245.7 | Canonical dynamics: Equilibrium phase-space distributions. | WG Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 92 | 9481 | 9481.0 | 250.4 | 250.4 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 93 | 18927 | 9463.5 | 389.4 | 194.7 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | False |
| 94 | 9448 | 9448.0 | 376.2 | 376.2 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 95 | 28052 | 9350.7 | 694.4 | 231.5 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 96 | 18604 | 9302.0 | 550.2 | 275.1 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 97 | 9259 | 9259.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 98 | 9254 | 9254.0 | 262.6 | 262.6 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 99 | 9199 | 9199.0 | 257.9 | 257.9 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | False |
| 100 | 9123 | 9123.0 | 234.6 | 234.6 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 101 | 18229 | 9114.5 | 390.5 | 195.2 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 102 | 9114 | 9114.0 | 232.9 | 232.9 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | False |
| 103 | 9075 | 9075.0 | 232.0 | 232.0 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | False |
| 104 | 26832 | 8944.0 | 1351.9 | 450.6 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 105 | 17858 | 8929.0 | 411.1 | 205.6 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 106 | 8913 | 8913.0 | 176.4 | 176.4 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 107 | 8800 | 8800.0 | 183.5 | 183.5 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | False |
| 108 | 8764 | 8764.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M HAMILTON | Br J Med Psychol | 1959 | 13638508 | Yes |
| 109 | 8742 | 8742.0 | 255.6 | 255.6 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 110 | 17234 | 8617.0 | 566.9 | 283.4 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 111 | 34067 | 8516.8 | 1096.2 | 274.1 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 112 | 8442 | 8442.0 | 385.9 | 385.9 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 113 | 24946 | 8315.3 | 740.7 | 246.9 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 114 | 16585 | 8292.5 | 370.6 | 185.3 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 115 | 16582 | 8291.0 | 383.2 | 191.6 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 116 | 8162 | 8162.0 | 220.4 | 220.4 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 117 | 8128 | 8128.0 | 195.5 | 195.5 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 118 | 16088 | 8044.0 | 387.0 | 193.5 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 119 | 7997 | 7997.0 | 194.4 | 194.4 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | False |
| 120 | 15915 | 7957.5 | 978.6 | 489.3 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 121 | 7932 | 7932.0 | 154.7 | 154.7 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | False |
| 122 | 7911 | 7911.0 | 217.9 | 217.9 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 123 | 7857 | 7857.0 | 163.6 | 163.6 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | False |
| 124 | 7855 | 7855.0 | 226.1 | 226.1 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 125 | 7812 | 7812.0 | 244.4 | 244.4 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 126 | 7796 | 7796.0 | 215.5 | 215.5 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | False |
| 127 | 7788 | 7788.0 | 330.0 | 330.0 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 128 | 7776 | 7776.0 | 253.4 | 253.4 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 129 | 23249 | 7749.7 | 902.0 | 300.7 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 130 | 23218 | 7739.3 | 797.4 | 265.8 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 131 | 7737 | 7737.0 | 328.1 | 328.1 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 132 | 7695 | 7695.0 | 218.4 | 218.4 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 133 | 7692 | 7692.0 | 266.5 | 266.5 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 134 | 7672 | 7672.0 | 220.1 | 220.1 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 135 | 7654 | 7654.0 | 228.4 | 228.4 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 136 | 52803 | 7543.3 | 1347.6 | 192.5 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | False |
| 137 | 14931 | 7465.5 | 409.2 | 204.6 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 138 | 7389 | 7389.0 | 119.1 | 119.1 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 139 | 7379 | 7379.0 | 189.8 | 189.8 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 140 | 7297 | 7297.0 | 239.7 | 239.7 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 141 | 14551 | 7275.5 | 389.3 | 194.7 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 142 | 14212 | 7106.0 | 366.1 | 183.1 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 143 | 7082 | 7082.0 | 191.8 | 191.8 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 144 | 14020 | 7010.0 | 768.5 | 384.2 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | False |
| 145 | 13920 | 6960.0 | 354.0 | 177.0 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 146 | 6907 | 6907.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J YOUDEN | Cancer | 1950 | 15405679 | Yes |
| 147 | 6853 | 6853.0 | 182.8 | 182.8 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | False |
| 148 | 6764 | 6764.0 | 116.3 | 116.3 | A Self-Rating Depression Scale. | W W ZUNG | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 149 | 6731 | 6731.0 | 131.4 | 131.4 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | False |
| 150 | 6714 | 6714.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L WARREN | J Biol Chem | 1959 | 13672998 | Yes |
| 151 | 6682 | 6682.0 | 216.3 | 216.3 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | False |
| 152 | 13342 | 6671.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N MANTEL, W HAENSZEL | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 153 | 6639 | 6639.0 | 151.2 | 151.2 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 154 | 13268 | 6634.0 | 309.4 | 154.7 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 155 | 6627 | 6627.0 | 152.7 | 152.7 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | False |
| 156 | 19793 | 6597.7 | 552.5 | 184.2 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 157 | 6591 | 6591.0 | 169.2 | 169.2 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | False |
| 158 | 6572 | 6572.0 | 170.5 | 170.5 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | False |
| 159 | 13096 | 6548.0 | 443.0 | 221.5 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 160 | 12945 | 6472.5 | 446.4 | 223.2 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 161 | 12888 | 6444.0 | 516.1 | 258.1 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 162 | 6433 | 6433.0 | 192.3 | 192.3 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | False |
| 163 | 6429 | 6429.0 | 151.3 | 151.3 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | False |
| 164 | 19271 | 6423.7 | 965.6 | 321.9 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 165 | 6419 | 6419.0 | 135.3 | 135.3 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | False |
| 166 | 6412 | 6412.0 | 128.9 | 128.9 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 167 | 6406 | 6406.0 | 148.4 | 148.4 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 168 | 6383 | 6383.0 | 147.0 | 147.0 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | False |
| 169 | 6368 | 6368.0 | 136.6 | 136.6 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | False |
| 170 | 6317 | 6317.0 | 116.4 | 116.4 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 171 | 12309 | 6154.5 | 332.8 | 166.4 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | False |
| 172 | 6149 | 6149.0 | 167.9 | 167.9 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 173 | 6148 | 6148.0 | 139.4 | 139.4 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 174 | 12274 | 6137.0 | 444.6 | 222.3 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 175 | 12237 | 6118.5 | 294.7 | 147.3 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 176 | 36691 | 6115.2 | 1244.1 | 207.3 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 177 | 12194 | 6097.0 | 261.2 | 130.6 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 178 | 12191 | 6095.5 | 278.6 | 139.3 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 179 | 6074 | 6074.0 | 147.0 | 147.0 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | False |
| 180 | 6071 | 6071.0 | 152.5 | 152.5 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | False |
| 181 | 6066 | 6066.0 | 196.1 | 196.1 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | False |
| 182 | 6053 | 6053.0 | 78.9 | 78.9 | The Environment And Disease: Association Or Causation? | A B HILL | Proc R Soc Med | 1965 | 14283879 | Yes |
| 183 | 6045 | 6045.0 | 131.8 | 131.8 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 184 | 6041 | 6041.0 | 151.3 | 151.3 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | False |
| 185 | 6019 | 6019.0 | 183.7 | 183.7 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 186 | 6017 | 6017.0 | 264.3 | 264.3 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | False |
| 187 | 23966 | 5991.5 | 788.7 | 197.2 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 188 | 5988 | 5988.0 | 134.4 | 134.4 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 189 | 5917 | 5917.0 | 206.3 | 206.3 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | False |
| 190 | 11737 | 5868.5 | 386.9 | 193.4 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 191 | 5805 | 5805.0 | 141.1 | 141.1 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 192 | 5779 | 5779.0 | 178.1 | 178.1 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 193 | 5759 | 5759.0 | 228.4 | 228.4 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 194 | 5749 | 5749.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D HARMAN | J Gerontol | 1956 | 13332224 | Yes |
| 195 | 11492 | 5746.0 | 282.8 | 141.4 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 196 | 5736 | 5736.0 | 148.1 | 148.1 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | False |
| 197 | 11461 | 5730.5 | 238.8 | 119.4 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | False |
| 198 | 5728 | 5728.0 | 150.4 | 150.4 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | False |
| 199 | 11453 | 5726.5 | 193.8 | 96.9 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T OMURA, R SATO | J Biol Chem | 1964 | 14209971 | Yes |
| 200 | 11440 | 5720.0 | 243.1 | 121.5 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 201 | 5713 | 5713.0 | 142.2 | 142.2 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | False |
| 202 | 11399 | 5699.5 | 248.0 | 124.0 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | False |
| 203 | 11384 | 5692.0 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V HAMBURGER, H L HAMILTON | J Morphol | 1951 | 24539719 | Yes |
| 204 | 5688 | 5688.0 | 119.2 | 119.2 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 205 | 11337 | 5668.5 | 442.2 | 221.1 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 206 | 22663 | 5665.8 | 556.3 | 139.1 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 207 | 5648 | 5648.0 | 94.7 | 94.7 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 208 | 5637 | 5637.0 | 210.8 | 210.8 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 209 | 16880 | 5626.7 | 624.5 | 208.2 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 210 | 11181 | 5590.5 | 255.9 | 128.0 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 211 | 5579 | 5579.0 | 89.4 | 89.4 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 212 | 11155 | 5577.5 | 527.8 | 263.9 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 213 | 22310 | 5577.5 | 644.2 | 161.1 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 214 | 5560 | 5560.0 | 118.7 | 118.7 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | False |
| 215 | 16634 | 5544.7 | 499.5 | 166.5 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 216 | 5522 | 5522.0 | 211.1 | 211.1 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 217 | 5516 | 5516.0 | 162.3 | 162.3 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 218 | 22063 | 5515.8 | 663.3 | 165.8 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 219 | 16526 | 5508.7 | 514.9 | 171.6 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 220 | 10945 | 5472.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L HODGKIN, A F HUXLEY | J Physiol | 1952 | 12991237 | Yes |
| 221 | 10925 | 5462.5 | 286.5 | 143.2 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 222 | 10843 | 5421.5 | 289.1 | 144.6 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 223 | 16246 | 5415.3 | 396.1 | 132.0 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 224 | 5400 | 5400.0 | 103.4 | 103.4 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | False |
| 225 | 10771 | 5385.5 | 299.8 | 149.9 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 226 | 5384 | 5384.0 | 136.0 | 136.0 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 227 | 26748 | 5349.6 | 718.0 | 143.6 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 228 | 5346 | 5346.0 | 54.2 | 54.2 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P LAUREN | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 229 | 16009 | 5336.3 | 628.0 | 209.3 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 230 | 5309 | 5309.0 | 127.3 | 127.3 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | False |
| 231 | 5302 | 5302.0 | 134.6 | 134.6 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 232 | 5299 | 5299.0 | 126.8 | 126.8 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | False |
| 233 | 5284 | 5284.0 | 103.9 | 103.9 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | False |
| 234 | 10553 | 5276.5 | 225.4 | 112.7 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | False |
| 235 | 5266 | 5266.0 | 151.8 | 151.8 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | False |
| 236 | 5257 | 5257.0 | 559.5 | 559.5 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | False |
| 237 | 10513 | 5256.5 | 248.6 | 124.3 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 238 | 10497 | 5248.5 | 349.5 | 174.8 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | False |
| 239 | 15715 | 5238.3 | 628.7 | 209.6 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | False |
| 240 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J SCHEIDEGGER | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 241 | 5218 | 5218.0 | 188.5 | 188.5 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | False |
| 242 | 5197 | 5197.0 | 68.3 | 68.3 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 243 | 10370 | 5185.0 | 365.9 | 182.9 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 244 | 10293 | 5146.5 | 177.9 | 89.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 245 | 5135 | 5135.0 | 101.4 | 101.4 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | False |
| 246 | 10250 | 5125.0 | 271.4 | 135.7 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 247 | 5115 | 5115.0 | 187.9 | 187.9 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 248 | 25532 | 5106.4 | 1046.5 | 209.3 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 249 | 10152 | 5076.0 | 166.5 | 83.2 | Functional Evaluation: The Barthel Index. | F I MAHONEY, D W BARTHEL | Md State Med J | 1965 | 14258950 | Yes |
| 250 | 5061 | 5061.0 | 143.9 | 143.9 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 251 | 10106 | 5053.0 | 264.4 | 132.2 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 252 | 10105 | 5052.5 | 237.8 | 118.9 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | False |
| 253 | 5051 | 5051.0 | 225.8 | 225.8 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | False |
| 254 | 5032 | 5032.0 | 118.0 | 118.0 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 255 | 14970 | 4990.0 | 539.6 | 179.9 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 256 | 24915 | 4983.0 | 419.0 | 83.8 | An inventory for measuring depression. | A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 257 | 4982 | 4982.0 | 152.0 | 152.0 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | False |
| 258 | 14907 | 4969.0 | 498.9 | 166.3 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 259 | 9937 | 4968.5 | 351.2 | 175.6 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 260 | 4965 | 4965.0 | 91.2 | 91.2 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | False |
| 261 | 14859 | 4953.0 | 527.6 | 175.9 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 262 | 4949 | 4949.0 | 122.8 | 122.8 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 263 | 14845 | 4948.3 | 647.0 | 215.7 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 264 | 14833 | 4944.3 | 469.1 | 156.4 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 265 | 4911 | 4911.0 | 156.1 | 156.1 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 266 | 9813 | 4906.5 | 221.8 | 110.9 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 267 | 9783 | 4891.5 | 350.0 | 175.0 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 268 | 14644 | 4881.3 | 392.8 | 130.9 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 269 | 4877 | 4877.0 | 97.3 | 97.3 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | False |
| 270 | 19421 | 4855.2 | 312.1 | 78.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 271 | 14503 | 4834.3 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G GORNALL, C J BARDAWILL, M M DAVID | J Biol Chem | 1949 | 18110453 | Yes |
| 272 | 14441 | 4813.7 | 356.5 | 118.8 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 273 | 4810 | 4810.0 | 206.8 | 206.8 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 274 | 4810 | 4810.0 | 107.2 | 107.2 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | False |
| 275 | 4806 | 4806.0 | 57.6 | 57.6 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M RODBELL | J Biol Chem | 1964 | 14169133 | Yes |
| 276 | 4790 | 4790.0 | 104.6 | 104.6 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | False |
| 277 | 4778 | 4778.0 | 103.6 | 103.6 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | False |
| 278 | 4777 | 4777.0 | 111.4 | 111.4 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 279 | 14279 | 4759.7 | 308.7 | 102.9 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 280 | 9517 | 4758.5 | 158.6 | 79.3 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 281 | 4752 | 4752.0 | 41.2 | 41.2 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L HAYFLICK | Exp Cell Res | 1965 | 14315085 | Yes |
| 282 | 4751 | 4751.0 | 104.1 | 104.1 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | False |
| 283 | 9486 | 4743.0 | 225.4 | 112.7 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 284 | 9462 | 4731.0 | 347.8 | 173.9 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 285 | 9453 | 4726.5 | 236.7 | 118.3 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 286 | 4706 | 4706.0 | 156.4 | 156.4 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | False |
| 287 | 4701 | 4701.0 | 265.0 | 265.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V BORN | Nature | 1962 | 13871375 | Yes |
| 288 | 32870 | 4695.7 | 714.3 | 102.0 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 289 | 4694 | 4694.0 | 94.4 | 94.4 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | False |
| 290 | 9358 | 4679.0 | 381.9 | 190.9 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 291 | 4678 | 4678.0 | 129.7 | 129.7 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 292 | 9352 | 4676.0 | 135.9 | 68.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 293 | 18667 | 4666.8 | 524.6 | 131.2 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 294 | 4651 | 4651.0 | 120.6 | 120.6 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 295 | 18574 | 4643.5 | 580.0 | 145.0 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
| 296 | 4623 | 4623.0 | 48.6 | 48.6 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 297 | 13849 | 4616.3 | 474.9 | 158.3 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | False |
| 298 | 9225 | 4612.5 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H KELLGREN, J S LAWRENCE | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 299 | 9212 | 4606.0 | 202.2 | 101.1 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 300 | 4570 | 4570.0 | 104.0 | 104.0 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | False |
| 301 | 9118 | 4559.0 | 226.7 | 113.3 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 302 | 4558 | 4558.0 | 95.0 | 95.0 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 303 | 4552 | 4552.0 | 91.1 | 91.1 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | False |
| 304 | 4544 | 4544.0 | 163.3 | 163.3 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | False |
| 305 | 4543 | 4543.0 | 96.6 | 96.6 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | False |
| 306 | 4542 | 4542.0 | 168.9 | 168.9 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | False |
| 307 | 4537 | 4537.0 | 139.1 | 139.1 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 308 | 9036 | 4518.0 | 260.3 | 130.2 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 309 | 9029 | 4514.5 | 240.0 | 120.0 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | False |
| 310 | 9013 | 4506.5 | 207.0 | 103.5 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 311 | 4506 | 4506.0 | 90.7 | 90.7 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 312 | 8967 | 4483.5 | 245.4 | 122.7 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 313 | 8939 | 4469.5 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T LITCHFIELD, F WILCOXON | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 314 | 4469 | 4469.0 | 86.1 | 86.1 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 315 | 4469 | 4469.0 | 84.2 | 84.2 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | False |
| 316 | 8937 | 4468.5 | 345.1 | 172.6 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
| 317 | 8930 | 4465.0 | 223.5 | 111.8 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 318 | 22245 | 4449.0 | 845.4 | 169.1 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 319 | 4448 | 4448.0 | 161.5 | 161.5 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 320 | 13344 | 4448.0 | 489.5 | 163.2 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 321 | 4444 | 4444.0 | 122.9 | 122.9 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 322 | 4434 | 4434.0 | 107.4 | 107.4 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 323 | 4411 | 4411.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B DE B WEIR | J Physiol | 1949 | 15394301 | Yes |
| 324 | 8802 | 4401.0 | 281.2 | 140.6 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 325 | 26399 | 4399.8 | 925.0 | 154.2 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 326 | 26366 | 4394.3 | 854.7 | 142.5 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 327 | 4386 | 4386.0 | 101.9 | 101.9 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | False |
| 328 | 8765 | 4382.5 | 162.1 | 81.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 329 | 4382 | 4382.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 330 | 4356 | 4356.0 | 128.7 | 128.7 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 331 | 4353 | 4353.0 | 221.4 | 221.4 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 332 | 4353 | 4353.0 | 92.7 | 92.7 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | False |
| 333 | 4338 | 4338.0 | 111.7 | 111.7 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | False |
| 334 | 4336 | 4336.0 | 111.1 | 111.1 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | False |
| 335 | 4329 | 4329.0 | 131.9 | 131.9 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | False |
| 336 | 4322 | 4322.0 | 127.9 | 127.9 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | False |
| 337 | 4295 | 4295.0 | 90.1 | 90.1 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 338 | 4292 | 4292.0 | 102.9 | 102.9 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | False |
| 339 | 8579 | 4289.5 | 467.3 | 233.7 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M HUNTER, F C GREENWOOD | Nature | 1962 | 14450081 | Yes |
| 340 | 8567 | 4283.5 | 203.5 | 101.8 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 341 | 4281 | 4281.0 | 119.0 | 119.0 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 342 | 4277 | 4277.0 | 109.5 | 109.5 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 343 | 8547 | 4273.5 | 265.1 | 132.6 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 344 | 4272 | 4272.0 | 112.9 | 112.9 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | False |
| 345 | 4268 | 4268.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M ABERCROMBIE | Anat Rec | 1946 | 21015608 | Yes |
| 346 | 4267 | 4267.0 | 91.8 | 91.8 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | False |
| 347 | 4265 | 4265.0 | 87.7 | 87.7 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | False |
| 348 | 4263 | 4263.0 | 108.7 | 108.7 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 349 | 4261 | 4261.0 | 93.6 | 93.6 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 350 | 8519 | 4259.5 | 217.1 | 108.5 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 351 | 4257 | 4257.0 | 75.9 | 75.9 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 352 | 4257 | 4257.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T NASH | Biochem J | 1953 | 13105648 | Yes |
| 353 | 4257 | 4257.0 | 117.4 | 117.4 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 354 | 8506 | 4253.0 | 224.6 | 112.3 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 355 | 4245 | 4245.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H EAGLE | Science | 1959 | 13675766 | Yes |
| 356 | 4226 | 4226.0 | 109.3 | 109.3 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 357 | 4220 | 4220.0 | 93.9 | 93.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 358 | 4213 | 4213.0 | 172.9 | 172.9 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 359 | 4210 | 4210.0 | 51.2 | 51.2 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 360 | 4205 | 4205.0 | 86.5 | 86.5 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | False |
| 361 | 4199 | 4199.0 | 104.5 | 104.5 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | False |
| 362 | 4199 | 4199.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P DOLE | J Clin Invest | 1956 | 13286333 | Yes |
| 363 | 4198 | 4198.0 | 140.5 | 140.5 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 364 | 8386 | 4193.0 | 210.5 | 105.2 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | False |
| 365 | 4187 | 4187.0 | 86.6 | 86.6 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | False |
| 366 | 4180 | 4180.0 | 174.4 | 174.4 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 367 | 4173 | 4173.0 | 80.3 | 80.3 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | False |
| 368 | 4171 | 4171.0 | 119.5 | 119.5 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 369 | 12484 | 4161.3 | 318.0 | 106.0 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 370 | 4160 | 4160.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M DIXON | Biochem J | 1953 | 13093635 | Yes |
| 371 | 4158 | 4158.0 | 72.7 | 72.7 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 372 | 4158 | 4158.0 | 111.9 | 111.9 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | False |
| 373 | 8306 | 4153.0 | 216.9 | 108.5 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | False |
| 374 | 8274 | 4137.0 | 177.3 | 88.7 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 375 | 4136 | 4136.0 | 105.3 | 105.3 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 376 | 4128 | 4128.0 | 127.9 | 127.9 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | False |
| 377 | 4128 | 4128.0 | 109.1 | 109.1 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | False |
| 378 | 4124 | 4124.0 | 99.8 | 99.8 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | False |
| 379 | 20599 | 4119.8 | 1232.7 | 246.5 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 380 | 4113 | 4113.0 | 110.8 | 110.8 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 381 | 8167 | 4083.5 | 176.0 | 88.0 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 382 | 4073 | 4073.0 | 85.2 | 85.2 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | False |
| 383 | 4072 | 4072.0 | 99.7 | 99.7 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 384 | 4068 | 4068.0 | 98.0 | 98.0 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 385 | 16221 | 4055.2 | 365.3 | 91.3 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 386 | 4045 | 4045.0 | 106.1 | 106.1 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 387 | 4045 | 4045.0 | 101.1 | 101.1 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | False |
| 388 | 8088 | 4044.0 | 190.2 | 95.1 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | False |
| 389 | 4016 | 4016.0 | 132.2 | 132.2 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | False |
| 390 | 4014 | 4014.0 | 107.0 | 107.0 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | False |
| 391 | 4014 | 4014.0 | 103.2 | 103.2 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | False |
| 392 | 8010 | 4005.0 | 150.9 | 75.5 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 393 | 3996 | 3996.0 | 128.0 | 128.0 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | False |
| 394 | 3993 | 3993.0 | 111.3 | 111.3 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | False |
| 395 | 3991 | 3991.0 | 81.7 | 81.7 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 396 | 11968 | 3989.3 | 321.1 | 107.0 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | False |
| 397 | 7958 | 3979.0 | 193.5 | 96.8 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | False |
| 398 | 7955 | 3977.5 | 149.7 | 74.8 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 399 | 3973 | 3973.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L WATSON | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 400 | 3950 | 3950.0 | 81.9 | 81.9 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | False |
| 401 | 3939 | 3939.0 | 89.9 | 89.9 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | False |
| 402 | 3937 | 3937.0 | 86.5 | 86.5 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | False |
| 403 | 3934 | 3934.0 | 95.6 | 95.6 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | False |
| 404 | 7848 | 3924.0 | 219.2 | 109.6 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 405 | 3918 | 3918.0 | 120.3 | 120.3 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | False |
| 406 | 7833 | 3916.5 | 193.7 | 96.8 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | False |
| 407 | 3914 | 3914.0 | 63.9 | 63.9 | Disc Electrophoresis. I. Background And Theory. | L ORNSTEIN | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 408 | 7810 | 3905.0 | 258.0 | 129.0 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 409 | 3897 | 3897.0 | 111.6 | 111.6 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | False |
| 410 | 7790 | 3895.0 | 210.8 | 105.4 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 411 | 3882 | 3882.0 | 119.1 | 119.1 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 412 | 3880 | 3880.0 | 67.0 | 67.0 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 413 | 3877 | 3877.0 | 142.9 | 142.9 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | False |
| 414 | 3877 | 3877.0 | 110.9 | 110.9 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | False |
| 415 | 3875 | 3875.0 | 75.6 | 75.6 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 416 | 3860 | 3860.0 | 103.8 | 103.8 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 417 | 11563 | 3854.3 | 275.3 | 91.8 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | False |
| 418 | 3853 | 3853.0 | 90.8 | 90.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | False |
| 419 | 3852 | 3852.0 | 127.8 | 127.8 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | False |
| 420 | 3846 | 3846.0 | 172.9 | 172.9 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 421 | 3844 | 3844.0 | 122.3 | 122.3 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 422 | 3840 | 3840.0 | 88.1 | 88.1 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 423 | 3831 | 3831.0 | 90.1 | 90.1 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 424 | 3826 | 3826.0 | 108.4 | 108.4 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | False |
| 425 | 3823 | 3823.0 | 102.6 | 102.6 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 426 | 3817 | 3817.0 | 89.9 | 89.9 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 427 | 3815 | 3815.0 | 110.4 | 110.4 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 428 | 3811 | 3811.0 | 138.2 | 138.2 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 429 | 3798 | 3798.0 | 77.6 | 77.6 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | False |
| 430 | 3793 | 3793.0 | 79.2 | 79.2 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 431 | 7586 | 3793.0 | 180.9 | 90.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | False |
| 432 | 15171 | 3792.8 | 538.9 | 134.7 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 433 | 3790 | 3790.0 | 115.2 | 115.2 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 434 | 3788 | 3788.0 | 97.3 | 97.3 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | False |
| 435 | 3782 | 3782.0 | 89.5 | 89.5 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
| 436 | 3774 | 3774.0 | 113.6 | 113.6 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 437 | 3771 | 3771.0 | 92.1 | 92.1 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | False |
| 438 | 3757 | 3757.0 | 65.3 | 65.3 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 439 | 7514 | 3757.0 | 163.3 | 81.7 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | False |
| 440 | 3753 | 3753.0 | 107.3 | 107.3 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 441 | 3747 | 3747.0 | 98.6 | 98.6 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | False |
| 442 | 11220 | 3740.0 | 213.9 | 71.3 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 443 | 3719 | 3719.0 | 66.0 | 66.0 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | False |
| 444 | 3716 | 3716.0 | 118.0 | 118.0 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 445 | 3704 | 3704.0 | 68.4 | 68.4 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 446 | 3691 | 3691.0 | 101.6 | 101.6 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | False |
| 447 | 3688 | 3688.0 | 90.2 | 90.2 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | False |
| 448 | 11058 | 3686.0 | 258.8 | 86.3 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 449 | 7368 | 3684.0 | 371.5 | 185.8 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 450 | 33105 | 3678.3 | 704.3 | 78.3 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 451 | 3676 | 3676.0 | 163.8 | 163.8 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | False |
| 452 | 32976 | 3664.0 | 999.3 | 111.0 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 453 | 3662 | 3662.0 | 76.0 | 76.0 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | False |
| 454 | 7302 | 3651.0 | 170.7 | 85.3 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 455 | 25459 | 3637.0 | 890.2 | 127.2 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 456 | 7253 | 3626.5 | 218.4 | 109.2 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 457 | 3624 | 3624.0 | 94.6 | 94.6 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | False |
| 458 | 3621 | 3621.0 | 84.3 | 84.3 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | False |
| 459 | 7237 | 3618.5 | 203.3 | 101.7 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 460 | 3612 | 3612.0 | 115.0 | 115.0 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 461 | 3612 | 3612.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A MILLER | Psychol Rev | 1956 | 13310704 | Yes |
| 462 | 3609 | 3609.0 | 108.3 | 108.3 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | False |
| 463 | 3609 | 3609.0 | 81.0 | 81.0 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | False |
| 464 | 7209 | 3604.5 | 128.3 | 64.2 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | False |
| 465 | 3602 | 3602.0 | 165.6 | 165.6 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 466 | 3600 | 3600.0 | 71.0 | 71.0 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | False |
| 467 | 10800 | 3600.0 | 346.9 | 115.6 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 468 | 3597 | 3597.0 | 80.3 | 80.3 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | False |
| 469 | 7186 | 3593.0 | 365.1 | 182.6 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H HUBEL, T N WIESEL | J Physiol | 1962 | 14449617 | Yes |
| 470 | 14351 | 3587.8 | 591.8 | 147.9 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 471 | 3581 | 3581.0 | 54.6 | 54.6 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 472 | 3576 | 3576.0 | 105.9 | 105.9 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | False |
| 473 | 3575 | 3575.0 | 67.0 | 67.0 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | False |
| 474 | 7131 | 3565.5 | 167.2 | 83.6 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 475 | 14249 | 3562.2 | 662.5 | 165.6 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 476 | 3555 | 3555.0 | 138.5 | 138.5 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 477 | 3553 | 3553.0 | 91.3 | 91.3 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | False |
| 478 | 7081 | 3540.5 | 137.0 | 68.5 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 479 | 3540 | 3540.0 | 76.3 | 76.3 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | False |
| 480 | 3535 | 3535.0 | 85.6 | 85.6 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | False |
| 481 | 7064 | 3532.0 | 145.7 | 72.8 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 482 | 3525 | 3525.0 | 116.2 | 116.2 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 483 | 3519 | 3519.0 | 56.9 | 56.9 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 484 | 7033 | 3516.5 | 207.9 | 104.0 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | False |
| 485 | 17563 | 3512.6 | 494.4 | 98.9 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 486 | 3510 | 3510.0 | 84.5 | 84.5 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | False |
| 487 | 3508 | 3508.0 | 52.2 | 52.2 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F WOESSNER | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 488 | 7004 | 3502.0 | 218.8 | 109.4 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 489 | 3502 | 3502.0 | 122.7 | 122.7 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | False |
| 490 | 7001 | 3500.5 | 256.7 | 128.3 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 491 | 3496 | 3496.0 | 94.3 | 94.3 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | False |
| 492 | 3495 | 3495.0 | 87.6 | 87.6 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | False |
| 493 | 10468 | 3489.3 | 246.8 | 82.3 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 494 | 3485 | 3485.0 | 58.9 | 58.9 | Statistical estimations in enzyme kinetics. | G N WILKINSON | Biochem J | 1961 | 13785321 | Yes |
| 495 | 6945 | 3472.5 | 131.9 | 66.0 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | False |
| 496 | 3465 | 3465.0 | 80.2 | 80.2 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | False |
| 497 | 3448 | 3448.0 | 131.0 | 131.0 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | False |
| 498 | 3445 | 3445.0 | 96.6 | 96.6 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 499 | 3443 | 3443.0 | 94.6 | 94.6 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 500 | 6882 | 3441.0 | 193.9 | 97.0 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | False |
| 501 | 6877 | 3438.5 | 182.6 | 91.3 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 502 | 3437 | 3437.0 | 107.8 | 107.8 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | False |
| 503 | 6872 | 3436.0 | 162.5 | 81.2 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 504 | 6847 | 3423.5 | 171.6 | 85.8 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | False |
| 505 | 6841 | 3420.5 | 181.8 | 90.9 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 506 | 6837 | 3418.5 | 142.8 | 71.4 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | False |
| 507 | 3418 | 3418.0 | 76.0 | 76.0 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | False |
| 508 | 3417 | 3417.0 | 76.8 | 76.8 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | False |
| 509 | 6832 | 3416.0 | 205.2 | 102.6 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 510 | 3412 | 3412.0 | 81.7 | 81.7 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | False |
| 511 | 3411 | 3411.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W KAUZMANN | Adv Protein Chem | 1959 | 14404936 | Yes |
| 512 | 3405 | 3405.0 | 68.7 | 68.7 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | False |
| 513 | 6807 | 3403.5 | 159.1 | 79.5 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | False |
| 514 | 3400 | 3400.0 | 65.1 | 65.1 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | False |
| 515 | 3399 | 3399.0 | 118.9 | 118.9 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | False |
| 516 | 10183 | 3394.3 | 243.4 | 81.1 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 517 | 37260 | 3387.3 | 765.9 | 69.6 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 518 | 3386 | 3386.0 | 90.9 | 90.9 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 519 | 10144 | 3381.3 | 117.4 | 39.1 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C GREENWOOD, W M HUNTER, J S GLOVER | Biochem J | 1963 | 14097352 | Yes |
| 520 | 3370 | 3370.0 | 81.2 | 81.2 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | False |
| 521 | 3364 | 3364.0 | 69.4 | 69.4 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | False |
| 522 | 3362 | 3362.0 | 68.5 | 68.5 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | False |
| 523 | 3359 | 3359.0 | 112.4 | 112.4 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 524 | 6709 | 3354.5 | 216.2 | 108.1 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 525 | 3347 | 3347.0 | 76.6 | 76.6 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
| 526 | 6688 | 3344.0 | 169.7 | 84.8 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | False |
| 527 | 6683 | 3341.5 | 202.4 | 101.2 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 528 | 3341 | 3341.0 | 68.2 | 68.2 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | False |
| 529 | 6679 | 3339.5 | 208.2 | 104.1 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 530 | 3333 | 3333.0 | 68.0 | 68.0 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 531 | 26546 | 3318.2 | 566.9 | 70.9 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 532 | 3318 | 3318.0 | 60.1 | 60.1 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | False |
| 533 | 6633 | 3316.5 | 159.3 | 79.7 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 534 | 3314 | 3314.0 | 87.8 | 87.8 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | False |
| 535 | 6628 | 3314.0 | 215.2 | 107.6 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | False |
| 536 | 3309 | 3309.0 | 99.7 | 99.7 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | False |
| 537 | 3303 | 3303.0 | 83.8 | 83.8 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | False |
| 538 | 9898 | 3299.3 | 274.5 | 91.5 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 539 | 3299 | 3299.0 | 46.2 | 46.2 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A YPHANTIS | Biochemistry | 1964 | 14155091 | Yes |
| 540 | 6587 | 3293.5 | 399.2 | 199.6 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | False |
| 541 | 3290 | 3290.0 | 132.5 | 132.5 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 542 | 6579 | 3289.5 | 269.5 | 134.8 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 543 | 3285 | 3285.0 | 106.4 | 106.4 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 544 | 6559 | 3279.5 | 56.3 | 28.1 | The serial cultivation of human diploid cell strains. | L HAYFLICK, P S MOORHEAD | Exp Cell Res | 1961 | 13905658 | Yes |
| 545 | 3273 | 3273.0 | 93.8 | 93.8 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 546 | 6541 | 3270.5 | 183.4 | 91.7 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | False |
| 547 | 6540 | 3270.0 | 104.8 | 52.4 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | False |
| 548 | 3270 | 3270.0 | 64.0 | 64.0 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | False |
| 549 | 6538 | 3269.0 | 184.3 | 92.2 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 550 | 3268 | 3268.0 | 69.5 | 69.5 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | False |
| 551 | 13023 | 3255.8 | 487.7 | 121.9 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 552 | 12993 | 3248.2 | 298.6 | 74.7 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 553 | 3245 | 3245.0 | 77.6 | 77.6 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | False |
| 554 | 3241 | 3241.0 | 93.4 | 93.4 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | False |
| 555 | 3237 | 3237.0 | 65.8 | 65.8 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | False |
| 556 | 3236 | 3236.0 | 124.9 | 124.9 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | False |
| 557 | 3234 | 3234.0 | 110.0 | 110.0 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | False |
| 558 | 6457 | 3228.5 | 160.5 | 80.2 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | False |
| 559 | 6442 | 3221.0 | 133.7 | 66.8 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | False |
| 560 | 3218 | 3218.0 | 74.5 | 74.5 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | False |
| 561 | 3210 | 3210.0 | 66.4 | 66.4 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | False |
| 562 | 9627 | 3209.0 | 179.3 | 59.8 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 563 | 3207 | 3207.0 | 65.9 | 65.9 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | False |
| 564 | 9617 | 3205.7 | 467.0 | 155.7 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | False |
| 565 | 6405 | 3202.5 | 160.1 | 80.0 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | False |
| 566 | 3197 | 3197.0 | 27.2 | 27.2 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F LYON | Nature | 1961 | 13764598 | Yes |
| 567 | 3197 | 3197.0 | 73.2 | 73.2 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 568 | 9574 | 3191.3 | 263.8 | 87.9 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hänzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 569 | 3190 | 3190.0 | 58.7 | 58.7 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 570 | 3187 | 3187.0 | 66.3 | 66.3 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | False |
| 571 | 3187 | 3187.0 | 51.3 | 51.3 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L HORN | Psychometrika | 1965 | 14306381 | Yes |
| 572 | 6342 | 3171.0 | 109.7 | 54.9 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 573 | 3169 | 3169.0 | 73.5 | 73.5 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | False |
| 574 | 9495 | 3165.0 | 268.8 | 89.6 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 575 | 3163 | 3163.0 | 86.9 | 86.9 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | False |
| 576 | 9485 | 3161.7 | 194.0 | 64.7 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 577 | 3161 | 3161.0 | 74.3 | 74.3 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 578 | 3159 | 3159.0 | 77.7 | 77.7 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | False |
| 579 | 3159 | 3159.0 | 126.4 | 126.4 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | False |
| 580 | 6304 | 3152.0 | 135.8 | 67.9 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | False |
| 581 | 3149 | 3149.0 | 69.3 | 69.3 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | False |
| 582 | 3148 | 3148.0 | 140.7 | 140.7 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 583 | 3142 | 3142.0 | 108.0 | 108.0 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 584 | 6281 | 3140.5 | 139.3 | 69.7 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | False |
| 585 | 3140 | 3140.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O OUCHTERLONY | Prog Allergy | 1958 | 13578996 | Yes |
| 586 | 9388 | 3129.3 | 396.9 | 132.3 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 587 | 12495 | 3123.8 | 357.0 | 89.2 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 588 | 6240 | 3120.0 | 147.3 | 73.7 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 589 | 3115 | 3115.0 | 104.5 | 104.5 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 590 | 6228 | 3114.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S REITMAN, S FRANKEL | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 591 | 3114 | 3114.0 | 84.4 | 84.4 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | False |
| 592 | 9336 | 3112.0 | 311.4 | 103.8 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 593 | 3110 | 3110.0 | 72.3 | 72.3 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 594 | 3104 | 3104.0 | 68.3 | 68.3 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | False |
| 595 | 6205 | 3102.5 | 578.1 | 289.1 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 596 | 6190 | 3095.0 | 129.6 | 64.8 | Emergence of scaling in random networks | A L Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 597 | 3095 | 3095.0 | 70.1 | 70.1 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | False |
| 598 | 12352 | 3088.0 | 713.4 | 178.3 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 599 | 6170 | 3085.0 | 288.1 | 144.1 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | False |
| 600 | 6170 | 3085.0 | 159.7 | 79.8 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 601 | 3084 | 3084.0 | 73.9 | 73.9 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 602 | 9226 | 3075.3 | 964.9 | 321.6 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 603 | 3075 | 3075.0 | 84.9 | 84.9 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | False |
| 604 | 3071 | 3071.0 | 95.3 | 95.3 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 605 | 12276 | 3069.0 | 284.5 | 71.1 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 606 | 3066 | 3066.0 | 85.9 | 85.9 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 607 | 3064 | 3064.0 | 92.3 | 92.3 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 608 | 9191 | 3063.7 | 296.0 | 98.7 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 609 | 9180 | 3060.0 | 204.7 | 68.2 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 610 | 3056 | 3056.0 | 47.7 | 47.7 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S HAKOMORI | J Biochem | 1964 | 14135466 | Yes |
| 611 | 3053 | 3053.0 | 91.1 | 91.1 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | False |
| 612 | 3052 | 3052.0 | 70.1 | 70.1 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | False |
| 613 | 6102 | 3051.0 | 125.4 | 62.7 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | False |
| 614 | 3047 | 3047.0 | 59.5 | 59.5 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | False |
| 615 | 9131 | 3043.7 | 210.6 | 70.2 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 616 | 3027 | 3027.0 | 55.1 | 55.1 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | False |
| 617 | 9075 | 3025.0 | 175.6 | 58.5 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 618 | 3023 | 3023.0 | 94.8 | 94.8 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 619 | 6035 | 3017.5 | 187.1 | 93.5 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | False |
| 620 | 3013 | 3013.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I SELDINGER | Acta Radiol (Stockh) | 1953 | 13057644 | Yes |
| 621 | 3009 | 3009.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E PALADE | J Exp Med | 1952 | 14927794 | Yes |
| 622 | 3008 | 3008.0 | 30.0 | 30.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P MITCHELL | Nature | 1961 | 13771349 | Yes |
| 623 | 3007 | 3007.0 | 149.1 | 149.1 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | False |
| 624 | 6010 | 3005.0 | 238.1 | 119.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 625 | 3002 | 3002.0 | 92.4 | 92.4 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 626 | 2996 | 2996.0 | 103.1 | 103.1 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | False |
| 627 | 5986 | 2993.0 | 191.5 | 95.8 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | False |
| 628 | 2990 | 2990.0 | 0.0 | 0.0 | The genetical structure of populations. | S WRIGHT | Ann Eugen | 1951 | 24540312 | Yes |
| 629 | 2989 | 2989.0 | 150.6 | 150.6 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | False |
| 630 | 5957 | 2978.5 | 124.8 | 62.4 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 631 | 2978 | 2978.0 | 70.1 | 70.1 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | False |
| 632 | 2977 | 2977.0 | 91.0 | 91.0 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | False |
| 633 | 2976 | 2976.0 | 68.0 | 68.0 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | False |
| 634 | 2975 | 2975.0 | 56.2 | 56.2 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 635 | 2975 | 2975.0 | 52.9 | 52.9 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 636 | 8914 | 2971.3 | 225.5 | 75.2 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 637 | 5938 | 2969.0 | 142.2 | 71.1 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 638 | 2969 | 2969.0 | 65.2 | 65.2 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | False |
| 639 | 2967 | 2967.0 | 87.6 | 87.6 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | False |
| 640 | 2967 | 2967.0 | 109.9 | 109.9 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | False |
| 641 | 2964 | 2964.0 | 72.7 | 72.7 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | False |
| 642 | 2963 | 2963.0 | 126.8 | 126.8 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 643 | 2958 | 2958.0 | 56.6 | 56.6 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | False |
| 644 | 2956 | 2956.0 | 57.5 | 57.5 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | False |
| 645 | 5909 | 2954.5 | 179.4 | 89.7 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 646 | 8851 | 2950.3 | 241.6 | 80.5 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 647 | 2945 | 2945.0 | 74.2 | 74.2 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 648 | 2939 | 2939.0 | 44.3 | 44.3 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | False |
| 649 | 2935 | 2935.0 | 61.4 | 61.4 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | False |
| 650 | 5855 | 2927.5 | 176.5 | 88.2 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | False |
| 651 | 2926 | 2926.0 | 61.9 | 61.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | False |
| 652 | 5851 | 2925.5 | 125.9 | 63.0 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | False |
| 653 | 8769 | 2923.0 | 194.1 | 64.7 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | False |
| 654 | 2919 | 2919.0 | 57.2 | 57.2 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 655 | 2910 | 2910.0 | 86.5 | 86.5 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 656 | 5819 | 2909.5 | 192.0 | 96.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 657 | 2909 | 2909.0 | 70.7 | 70.7 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 658 | 2909 | 2909.0 | 68.4 | 68.4 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 659 | 2907 | 2907.0 | 52.5 | 52.5 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | False |
| 660 | 8721 | 2907.0 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J HAVEL, H A EDER, J H BRAGDON | J Clin Invest | 1955 | 13252080 | Yes |
| 661 | 17439 | 2906.5 | 853.0 | 142.2 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 662 | 5812 | 2906.0 | 162.1 | 81.0 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | False |
| 663 | 2903 | 2903.0 | 59.8 | 59.8 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | False |
| 664 | 2900 | 2900.0 | 88.3 | 88.3 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 665 | 2896 | 2896.0 | 71.8 | 71.8 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | False |
| 666 | 2895 | 2895.0 | 72.8 | 72.8 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | False |
| 667 | 5787 | 2893.5 | 196.1 | 98.0 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 668 | 5781 | 2890.5 | 130.4 | 65.2 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | False |
| 669 | 5779 | 2889.5 | 249.5 | 124.8 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 670 | 2889 | 2889.0 | 0.0 | 0.0 | Notes on sugar determination. | M SMOGYI | J Biol Chem | 1952 | 14938350 | Yes |
| 671 | 2887 | 2887.0 | 95.2 | 95.2 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | False |
| 672 | 2887 | 2887.0 | 50.0 | 50.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A GEHAN | Biometrika | 1965 | 14341275 | Yes |
| 673 | 2884 | 2884.0 | 48.5 | 48.5 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | False |
| 674 | 2882 | 2882.0 | 86.4 | 86.4 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | False |
| 675 | 2882 | 2882.0 | 81.3 | 81.3 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | False |
| 676 | 2882 | 2882.0 | 75.4 | 75.4 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 677 | 2870 | 2870.0 | 50.6 | 50.6 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 678 | 2866 | 2866.0 | 128.4 | 128.4 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 679 | 5732 | 2866.0 | 114.9 | 57.5 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 680 | 17175 | 2862.5 | 373.8 | 62.3 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 681 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C SCHNEIDER | J Biol Chem | 1945 | 21005736 | Yes |
| 682 | 5719 | 2859.5 | 154.0 | 77.0 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | False |
| 683 | 5716 | 2858.0 | 194.9 | 97.5 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 684 | 2855 | 2855.0 | 82.7 | 82.7 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 685 | 2851 | 2851.0 | 129.7 | 129.7 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 686 | 8552 | 2850.7 | 246.8 | 82.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 687 | 2850 | 2850.0 | 67.5 | 67.5 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | False |
| 688 | 5692 | 2846.0 | 111.0 | 55.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | False |
| 689 | 2841 | 2841.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P AHLQUIST | Am J Physiol | 1948 | 18882199 | Yes |
| 690 | 2839 | 2839.0 | 60.3 | 60.3 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | False |
| 691 | 5675 | 2837.5 | 167.6 | 83.8 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | False |
| 692 | 2837 | 2837.0 | 96.4 | 96.4 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 693 | 2828 | 2828.0 | 123.4 | 123.4 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | False |
| 694 | 5647 | 2823.5 | 171.0 | 85.5 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 695 | 2823 | 2823.0 | 71.7 | 71.7 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | False |
| 696 | 5642 | 2821.0 | 159.0 | 79.5 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 697 | 5640 | 2820.0 | 202.6 | 101.3 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 698 | 2817 | 2817.0 | 89.5 | 89.5 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | False |
| 699 | 2814 | 2814.0 | 110.3 | 110.3 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 700 | 2806 | 2806.0 | 93.6 | 93.6 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 701 | 5607 | 2803.5 | 152.0 | 76.0 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 702 | 2803 | 2803.0 | 65.3 | 65.3 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | False |
| 703 | 5603 | 2801.5 | 125.8 | 62.9 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | False |
| 704 | 2801 | 2801.0 | 75.6 | 75.6 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | False |
| 705 | 5597 | 2798.5 | 134.2 | 67.1 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | False |
| 706 | 5596 | 2798.0 | 132.0 | 66.0 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 707 | 5590 | 2795.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D WATSON, F H CRICK | Nature | 1953 | 13054692 | Yes |
| 708 | 5584 | 2792.0 | 315.2 | 157.6 | A modified uronic acid carbazole reaction. | T BITTER, H M MUIR | Anal Biochem | 1962 | 13971270 | Yes |
| 709 | 2791 | 2791.0 | 63.7 | 63.7 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | False |
| 710 | 5580 | 2790.0 | 77.8 | 38.9 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G MARTIN, B N AMES | J Biol Chem | 1961 | 13767412 | Yes |
| 711 | 2786 | 2786.0 | 152.3 | 152.3 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | False |
| 712 | 2785 | 2785.0 | 63.3 | 63.3 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 713 | 5566 | 2783.0 | 157.9 | 79.0 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 714 | 11131 | 2782.8 | 294.8 | 73.7 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 715 | 5565 | 2782.5 | 171.1 | 85.5 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 716 | 2781 | 2781.0 | 62.0 | 62.0 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | False |
| 717 | 2780 | 2780.0 | 87.9 | 87.9 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 718 | 2777 | 2777.0 | 83.5 | 83.5 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 719 | 2774 | 2774.0 | 53.0 | 53.0 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 720 | 2772 | 2772.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 721 | 2771 | 2771.0 | 111.1 | 111.1 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 722 | 8310 | 2770.0 | 219.8 | 73.3 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 723 | 5531 | 2765.5 | 167.0 | 83.5 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | False |
| 724 | 2758 | 2758.0 | 24.0 | 24.0 | Satellite cell of skeletal muscle fibers. | A MAURO | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 725 | 2757 | 2757.0 | 55.7 | 55.7 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 726 | 5509 | 2754.5 | 133.2 | 66.6 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | False |
| 727 | 2753 | 2753.0 | 61.5 | 61.5 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | False |
| 728 | 11011 | 2752.8 | 319.7 | 79.9 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 729 | 2750 | 2750.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L SVENNERHOLM | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 730 | 2749 | 2749.0 | 65.8 | 65.8 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | False |
| 731 | 5497 | 2748.5 | 159.2 | 79.6 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 732 | 2747 | 2747.0 | 60.7 | 60.7 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 733 | 2746 | 2746.0 | 60.5 | 60.5 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | False |
| 734 | 5490 | 2745.0 | 144.1 | 72.0 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 735 | 2743 | 2743.0 | 60.8 | 60.8 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | False |
| 736 | 5469 | 2734.5 | 107.7 | 53.9 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 737 | 2728 | 2728.0 | 74.8 | 74.8 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 738 | 2723 | 2723.0 | 67.0 | 67.0 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | False |
| 739 | 8147 | 2715.7 | 174.3 | 58.1 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 740 | 5423 | 2711.5 | 215.3 | 107.7 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 741 | 2709 | 2709.0 | 107.8 | 107.8 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 742 | 5417 | 2708.5 | 108.3 | 54.1 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J SILNESS, H LOE | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 743 | 2707 | 2707.0 | 89.3 | 89.3 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | False |
| 744 | 5410 | 2705.0 | 109.4 | 54.7 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | False |
| 745 | 8107 | 2702.3 | 205.4 | 68.5 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | False |
| 746 | 2699 | 2699.0 | 64.9 | 64.9 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | False |
| 747 | 10794 | 2698.5 | 226.7 | 56.7 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 748 | 5396 | 2698.0 | 175.1 | 87.5 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | False |
| 749 | 2697 | 2697.0 | 63.2 | 63.2 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 750 | 8080 | 2693.3 | 207.0 | 69.0 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 751 | 2690 | 2690.0 | 141.6 | 141.6 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 752 | 10758 | 2689.5 | 252.7 | 63.2 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | False |
| 753 | 2689 | 2689.0 | 82.8 | 82.8 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | False |
| 754 | 5376 | 2688.0 | 102.8 | 51.4 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | False |
| 755 | 2687 | 2687.0 | 73.5 | 73.5 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | False |
| 756 | 2680 | 2680.0 | 50.9 | 50.9 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | False |
| 757 | 2679 | 2679.0 | 96.6 | 96.6 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | False |
| 758 | 8029 | 2676.3 | 195.8 | 65.3 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 759 | 2675 | 2675.0 | 51.2 | 51.2 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | False |
| 760 | 2673 | 2673.0 | 63.4 | 63.4 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 761 | 2672 | 2672.0 | 66.2 | 66.2 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 762 | 5336 | 2668.0 | 231.2 | 115.6 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 763 | 2668 | 2668.0 | 56.2 | 56.2 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | False |
| 764 | 2666 | 2666.0 | 54.5 | 54.5 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | False |
| 765 | 5323 | 2661.5 | 118.3 | 59.1 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | False |
| 766 | 2661 | 2661.0 | 74.0 | 74.0 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 767 | 5321 | 2660.5 | 135.1 | 67.5 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 768 | 2660 | 2660.0 | 58.9 | 58.9 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 769 | 2660 | 2660.0 | 61.8 | 61.8 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | False |
| 770 | 7976 | 2658.7 | 192.7 | 64.2 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | False |
| 771 | 2657 | 2657.0 | 57.4 | 57.4 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | False |
| 772 | 2650 | 2650.0 | 65.8 | 65.8 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | False |
| 773 | 5297 | 2648.5 | 170.9 | 85.5 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | False |
| 774 | 5296 | 2648.0 | 71.3 | 35.6 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 775 | 2647 | 2647.0 | 68.3 | 68.3 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | False |
| 776 | 2646 | 2646.0 | 63.7 | 63.7 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | False |
| 777 | 5291 | 2645.5 | 139.3 | 69.7 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | False |
| 778 | 2645 | 2645.0 | 75.7 | 75.7 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | False |
| 779 | 2644 | 2644.0 | 106.0 | 106.0 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 780 | 2640 | 2640.0 | 49.2 | 49.2 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | False |
| 781 | 5278 | 2639.0 | 121.5 | 60.8 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 782 | 5277 | 2638.5 | 143.5 | 71.8 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 783 | 2637 | 2637.0 | 69.8 | 69.8 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | False |
| 784 | 2633 | 2633.0 | 72.0 | 72.0 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 785 | 5253 | 2626.5 | 153.3 | 76.7 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 786 | 2624 | 2624.0 | 106.7 | 106.7 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | False |
| 787 | 5237 | 2618.5 | 128.0 | 64.0 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 788 | 5229 | 2614.5 | 116.7 | 58.4 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | False |
| 789 | 2614 | 2614.0 | 55.3 | 55.3 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | False |
| 790 | 5227 | 2613.5 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O ARUNLAKSHANA, H O SCHILD | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 791 | 2612 | 2612.0 | 106.9 | 106.9 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | False |
| 792 | 5223 | 2611.5 | 180.7 | 90.3 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 793 | 2606 | 2606.0 | 55.1 | 55.1 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | False |
| 794 | 5210 | 2605.0 | 160.7 | 80.3 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | False |
| 795 | 2602 | 2602.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 796 | 10400 | 2600.0 | 262.1 | 65.5 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 797 | 7788 | 2596.0 | 318.1 | 106.0 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 798 | 2591 | 2591.0 | 55.0 | 55.0 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | False |
| 799 | 2590 | 2590.0 | 36.4 | 36.4 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | False |
| 800 | 5180 | 2590.0 | 109.1 | 54.5 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 801 | 2589 | 2589.0 | 80.4 | 80.4 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 802 | 7767 | 2589.0 | 228.2 | 76.1 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 803 | 2588 | 2588.0 | 78.0 | 78.0 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | False |
| 804 | 5175 | 2587.5 | 128.4 | 64.2 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 805 | 2585 | 2585.0 | 97.4 | 97.4 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 806 | 5165 | 2582.5 | 125.3 | 62.6 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | False |
| 807 | 2580 | 2580.0 | 85.2 | 85.2 | Working memory. | A Baddeley | Science | 1992 | 1736359 | False |
| 808 | 2579 | 2579.0 | 120.5 | 120.5 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | False |
| 809 | 5152 | 2576.0 | 101.8 | 50.9 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 810 | 2573 | 2573.0 | 73.1 | 73.1 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 811 | 2572 | 2572.0 | 63.8 | 63.8 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | False |
| 812 | 2569 | 2569.0 | 61.3 | 61.3 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | False |
| 813 | 2566 | 2566.0 | 63.1 | 63.1 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | False |
| 814 | 2565 | 2565.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R PORTER | Biochem J | 1959 | 14434282 | Yes |
| 815 | 2563 | 2563.0 | 114.5 | 114.5 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 816 | 5102 | 2551.0 | 276.2 | 138.1 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 817 | 5101 | 2550.5 | 110.8 | 55.4 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | False |
| 818 | 2550 | 2550.0 | 80.6 | 80.6 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | False |
| 819 | 7645 | 2548.3 | 213.8 | 71.3 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | False |
| 820 | 2545 | 2545.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O SMITHIES | Biochem J | 1955 | 13276348 | Yes |
| 821 | 2544 | 2544.0 | 50.9 | 50.9 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | False |
| 822 | 2544 | 2544.0 | 126.6 | 126.6 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S BOYDEN | J Exp Med | 1962 | 13872176 | Yes |
| 823 | 2543 | 2543.0 | 78.4 | 78.4 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 824 | 2541 | 2541.0 | 55.6 | 55.6 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | False |
| 825 | 5069 | 2534.5 | 217.5 | 108.8 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 826 | 40462 | 2528.9 | 1247.6 | 78.0 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 827 | 2527 | 2527.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M FITTS | J Exp Psychol | 1954 | 13174710 | Yes |
| 828 | 2526 | 2526.0 | 103.0 | 103.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 829 | 5049 | 2524.5 | 121.3 | 60.6 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 830 | 5046 | 2523.0 | 142.8 | 71.4 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 831 | 2522 | 2522.0 | 90.3 | 90.3 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 832 | 5040 | 2520.0 | 146.2 | 73.1 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 833 | 5037 | 2518.5 | 137.9 | 69.0 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 834 | 2516 | 2516.0 | 44.4 | 44.4 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | False |
| 835 | 2515 | 2515.0 | 77.0 | 77.0 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | False |
| 836 | 2514 | 2514.0 | 74.9 | 74.9 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | False |
| 837 | 2512 | 2512.0 | 73.5 | 73.5 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 838 | 7519 | 2506.3 | 305.5 | 101.8 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 839 | 5007 | 2503.5 | 70.5 | 35.2 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H LOE, J SILNESS | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 840 | 5007 | 2503.5 | 165.1 | 82.5 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 841 | 2503 | 2503.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 842 | 5005 | 2502.5 | 96.2 | 48.1 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | False |
| 843 | 2502 | 2502.0 | 68.5 | 68.5 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | False |
| 844 | 2498 | 2498.0 | 60.1 | 60.1 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 845 | 2494 | 2494.0 | 75.3 | 75.3 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
| 846 | 4983 | 2491.5 | 180.4 | 90.2 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 847 | 2491 | 2491.0 | 57.3 | 57.3 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | False |
| 848 | 2491 | 2491.0 | 67.0 | 67.0 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | False |
| 849 | 4969 | 2484.5 | 159.6 | 79.8 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 850 | 4961 | 2480.5 | 147.1 | 73.5 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | False |
| 851 | 4960 | 2480.0 | 160.7 | 80.3 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 852 | 4958 | 2479.0 | 131.5 | 65.8 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | False |
| 853 | 2473 | 2473.0 | 111.8 | 111.8 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 854 | 2472 | 2472.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S LENNOX | Virology | 1955 | 13267987 | Yes |
| 855 | 2472 | 2472.0 | 50.6 | 50.6 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | False |
| 856 | 2470 | 2470.0 | 69.5 | 69.5 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 857 | 2469 | 2469.0 | 78.7 | 78.7 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 858 | 2469 | 2469.0 | 44.2 | 44.2 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | False |
| 859 | 2464 | 2464.0 | 43.9 | 43.9 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 860 | 4927 | 2463.5 | 93.8 | 46.9 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | False |
| 861 | 2463 | 2463.0 | 103.7 | 103.7 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | False |
| 862 | 2458 | 2458.0 | 81.6 | 81.6 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 863 | 2458 | 2458.0 | 52.2 | 52.2 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | False |
| 864 | 2455 | 2455.0 | 47.3 | 47.3 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 865 | 2451 | 2451.0 | 67.1 | 67.1 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | False |
| 866 | 4899 | 2449.5 | 128.1 | 64.0 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 867 | 2448 | 2448.0 | 61.6 | 61.6 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | False |
| 868 | 2447 | 2447.0 | 94.5 | 94.5 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 869 | 4894 | 2447.0 | 94.7 | 47.4 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | False |
| 870 | 2447 | 2447.0 | 69.2 | 69.2 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | False |
| 871 | 2445 | 2445.0 | 53.9 | 53.9 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | False |
| 872 | 2443 | 2443.0 | 53.0 | 53.0 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | False |
| 873 | 2442 | 2442.0 | 65.2 | 65.2 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 874 | 2440 | 2440.0 | 60.3 | 60.3 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | False |
| 875 | 4880 | 2440.0 | 128.7 | 64.3 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | False |
| 876 | 7316 | 2438.7 | 155.9 | 52.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | False |
| 877 | 7312 | 2437.3 | 378.2 | 126.1 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 878 | 2436 | 2436.0 | 75.8 | 75.8 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | False |
| 879 | 4870 | 2435.0 | 105.1 | 52.5 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | False |
| 880 | 9738 | 2434.5 | 206.5 | 51.6 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 881 | 2433 | 2433.0 | 51.8 | 51.8 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | False |
| 882 | 2432 | 2432.0 | 62.0 | 62.0 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | False |
| 883 | 4861 | 2430.5 | 159.0 | 79.5 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 884 | 4857 | 2428.5 | 120.1 | 60.0 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | False |
| 885 | 4853 | 2426.5 | 117.1 | 58.5 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 886 | 4852 | 2426.0 | 143.0 | 71.5 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 887 | 9693 | 2423.2 | 208.8 | 52.2 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 888 | 2419 | 2419.0 | 31.0 | 31.0 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T HIGUCHI | J Pharm Sci | 1963 | 14088963 | Yes |
| 889 | 2413 | 2413.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G BERTANI | J Bacteriol | 1951 | 14888646 | Yes |
| 890 | 2412 | 2412.0 | 58.3 | 58.3 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | False |
| 891 | 2410 | 2410.0 | 54.8 | 54.8 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | False |
| 892 | 2410 | 2410.0 | 58.1 | 58.1 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | False |
| 893 | 2409 | 2409.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F HUXLEY | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 894 | 4815 | 2407.5 | 174.3 | 87.2 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | False |
| 895 | 2406 | 2406.0 | 52.0 | 52.0 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | False |
| 896 | 2403 | 2403.0 | 67.3 | 67.3 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 897 | 2401 | 2401.0 | 77.5 | 77.5 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | False |
| 898 | 9604 | 2401.0 | 191.4 | 47.9 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 899 | 2397 | 2397.0 | 49.1 | 49.1 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | False |
| 900 | 2396 | 2396.0 | 62.6 | 62.6 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 901 | 2392 | 2392.0 | 61.4 | 61.4 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | False |
| 902 | 2392 | 2392.0 | 63.3 | 63.3 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | False |
| 903 | 7174 | 2391.3 | 188.8 | 62.9 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
| 904 | 4782 | 2391.0 | 97.4 | 48.7 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | False |
| 905 | 2391 | 2391.0 | 61.8 | 61.8 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 906 | 2391 | 2391.0 | 61.2 | 61.2 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | False |
| 907 | 4779 | 2389.5 | 108.9 | 54.5 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | False |
| 908 | 11946 | 2389.2 | 272.3 | 54.5 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 909 | 4776 | 2388.0 | 104.5 | 52.2 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | False |
| 910 | 4772 | 2386.0 | 118.4 | 59.2 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | False |
| 911 | 2386 | 2386.0 | 69.1 | 69.1 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | False |
| 912 | 4770 | 2385.0 | 126.0 | 63.0 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 913 | 2384 | 2384.0 | 73.4 | 73.4 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 914 | 2383 | 2383.0 | 49.3 | 49.3 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | False |
| 915 | 7146 | 2382.0 | 70.6 | 23.5 | On The Nature Of Allosteric Transitions: A Plausible Model. | J MONOD, J WYMAN, J P CHANGEUX | J Mol Biol | 1965 | 14343300 | Yes |
| 916 | 2382 | 2382.0 | 159.7 | 159.7 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | False |
| 917 | 2381 | 2381.0 | 55.0 | 55.0 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | False |
| 918 | 4759 | 2379.5 | 90.7 | 45.4 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | False |
| 919 | 4755 | 2377.5 | 124.5 | 62.2 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 920 | 2375 | 2375.0 | 80.3 | 80.3 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
| 921 | 4749 | 2374.5 | 173.4 | 86.7 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | False |
| 922 | 2373 | 2373.0 | 56.0 | 56.0 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | False |
| 923 | 2371 | 2371.0 | 98.1 | 98.1 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 924 | 2370 | 2370.0 | 127.4 | 127.4 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | False |
| 925 | 4736 | 2368.0 | 129.5 | 64.8 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | False |
| 926 | 2367 | 2367.0 | 58.7 | 58.7 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | False |
| 927 | 7100 | 2366.7 | 217.4 | 72.5 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 928 | 4732 | 2366.0 | 133.2 | 66.6 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | False |
| 929 | 2365 | 2365.0 | 79.7 | 79.7 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 930 | 4729 | 2364.5 | 103.0 | 51.5 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | False |
| 931 | 4726 | 2363.0 | 88.6 | 44.3 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 932 | 4717 | 2358.5 | 110.3 | 55.1 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | False |
| 933 | 2358 | 2358.0 | 56.7 | 56.7 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | False |
| 934 | 4699 | 2349.5 | 134.2 | 67.1 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | False |
| 935 | 2349 | 2349.0 | 127.7 | 127.7 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | False |
| 936 | 2347 | 2347.0 | 73.0 | 73.0 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | False |
| 937 | 2346 | 2346.0 | 39.8 | 39.8 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 938 | 4692 | 2346.0 | 96.1 | 48.0 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | False |
| 939 | 4688 | 2344.0 | 117.9 | 59.0 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 940 | 2343 | 2343.0 | 51.8 | 51.8 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | False |
| 941 | 2342 | 2342.0 | 134.5 | 134.5 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 942 | 2341 | 2341.0 | 57.8 | 57.8 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | False |
| 943 | 7022 | 2340.7 | 191.6 | 63.9 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | False |
| 944 | 2340 | 2340.0 | 66.0 | 66.0 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | False |
| 945 | 4674 | 2337.0 | 77.1 | 38.5 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 946 | 4670 | 2335.0 | 102.8 | 51.4 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 947 | 2331 | 2331.0 | 84.4 | 84.4 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | False |
| 948 | 4661 | 2330.5 | 87.7 | 43.9 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 949 | 2330 | 2330.0 | 56.1 | 56.1 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | False |
| 950 | 6985 | 2328.3 | 201.0 | 67.0 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | False |
| 951 | 2326 | 2326.0 | 45.0 | 45.0 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | False |
| 952 | 2324 | 2324.0 | 43.0 | 43.0 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | False |
| 953 | 2321 | 2321.0 | 124.5 | 124.5 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 954 | 2320 | 2320.0 | 90.8 | 90.8 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 955 | 2319 | 2319.0 | 65.5 | 65.5 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | False |
| 956 | 4636 | 2318.0 | 129.9 | 65.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 957 | 4636 | 2318.0 | 115.0 | 57.5 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | False |
| 958 | 2318 | 2318.0 | 125.2 | 125.2 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 959 | 2314 | 2314.0 | 42.5 | 42.5 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | False |
| 960 | 9228 | 2307.0 | 433.5 | 108.4 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 961 | 2307 | 2307.0 | 68.9 | 68.9 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | False |
| 962 | 2306 | 2306.0 | 71.5 | 71.5 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | False |
| 963 | 2305 | 2305.0 | 71.4 | 71.4 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | False |
| 964 | 9210 | 2302.5 | 214.7 | 53.7 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 965 | 4604 | 2302.0 | 69.1 | 34.5 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 966 | 2301 | 2301.0 | 56.7 | 56.7 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | False |
| 967 | 2298 | 2298.0 | 46.6 | 46.6 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 968 | 2296 | 2296.0 | 56.5 | 56.5 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | False |
| 969 | 2294 | 2294.0 | 85.4 | 85.4 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 970 | 2292 | 2292.0 | 56.6 | 56.6 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | False |
| 971 | 4578 | 2289.0 | 114.9 | 57.5 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | False |
| 972 | 4574 | 2287.0 | 90.4 | 45.2 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 973 | 2284 | 2284.0 | 61.3 | 61.3 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 974 | 2283 | 2283.0 | 52.2 | 52.2 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 975 | 2282 | 2282.0 | 75.8 | 75.8 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | False |
| 976 | 4564 | 2282.0 | 75.8 | 37.9 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 977 | 2282 | 2282.0 | 45.2 | 45.2 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 978 | 2277 | 2277.0 | 69.0 | 69.0 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | False |
| 979 | 4551 | 2275.5 | 108.8 | 54.4 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | False |
| 980 | 6818 | 2272.7 | 263.8 | 87.9 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 981 | 4541 | 2270.5 | 188.6 | 94.3 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | False |
| 982 | 2269 | 2269.0 | 49.4 | 49.4 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | False |
| 983 | 4535 | 2267.5 | 108.4 | 54.2 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 984 | 2267 | 2267.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A CLAUSS | Acta Haematol | 1957 | 13434757 | Yes |
| 985 | 4530 | 2265.0 | 167.1 | 83.5 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | False |
| 986 | 2264 | 2264.0 | 91.2 | 91.2 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | False |
| 987 | 2263 | 2263.0 | 60.8 | 60.8 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 988 | 4526 | 2263.0 | 115.2 | 57.6 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | False |
| 989 | 4522 | 2261.0 | 132.4 | 66.2 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 990 | 2261 | 2261.0 | 138.3 | 138.3 | Application of a microtechnique to viral serological investigations. | J L SEVER | J Immunol | 1962 | 13910995 | Yes |
| 991 | 4518 | 2259.0 | 89.2 | 44.6 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 992 | 2259 | 2259.0 | 47.4 | 47.4 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | False |
| 993 | 2258 | 2258.0 | 47.3 | 47.3 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | False |
| 994 | 18052 | 2256.5 | 709.4 | 88.7 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 995 | 6763 | 2254.3 | 136.4 | 45.5 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 996 | 6763 | 2254.3 | 200.1 | 66.7 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 997 | 2251 | 2251.0 | 48.6 | 48.6 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 998 | 2250 | 2250.0 | 67.8 | 67.8 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | False |
| 999 | 2250 | 2250.0 | 53.0 | 53.0 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | False |
| 1000 | 4499 | 2249.5 | 39.2 | 19.6 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 1001 | 4497 | 2248.5 | 102.5 | 51.2 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 1002 | 2247 | 2247.0 | 48.2 | 48.2 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | False |
| 1003 | 4493 | 2246.5 | 128.7 | 64.3 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 1004 | 4491 | 2245.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B SCOVILLE, B MILNER | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1005 | 2244 | 2244.0 | 56.0 | 56.0 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | False |
| 1006 | 2244 | 2244.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H PENNES | J Appl Physiol | 1948 | 18887578 | Yes |
| 1007 | 2242 | 2242.0 | 61.1 | 61.1 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | False |
| 1008 | 2242 | 2242.0 | 115.7 | 115.7 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 1009 | 2241 | 2241.0 | 54.9 | 54.9 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 1010 | 2238 | 2238.0 | 76.7 | 76.7 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | False |
| 1011 | 2238 | 2238.0 | 51.1 | 51.1 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | False |
| 1012 | 4475 | 2237.5 | 186.9 | 93.5 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1013 | 2237 | 2237.0 | 49.9 | 49.9 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | False |
| 1014 | 2236 | 2236.0 | 54.5 | 54.5 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1015 | 6696 | 2232.0 | 269.6 | 89.9 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | False |
| 1016 | 6695 | 2231.7 | 154.2 | 51.4 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1017 | 4463 | 2231.5 | 109.6 | 54.8 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | False |
| 1018 | 4463 | 2231.5 | 148.4 | 74.2 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | False |
| 1019 | 2230 | 2230.0 | 111.5 | 111.5 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | False |
| 1020 | 2230 | 2230.0 | 57.6 | 57.6 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | False |
| 1021 | 2229 | 2229.0 | 48.9 | 48.9 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | False |
| 1022 | 2228 | 2228.0 | 65.7 | 65.7 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 1023 | 4455 | 2227.5 | 85.8 | 42.9 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | False |
| 1024 | 2227 | 2227.0 | 49.2 | 49.2 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | False |
| 1025 | 4453 | 2226.5 | 103.1 | 51.5 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | False |
| 1026 | 2225 | 2225.0 | 53.3 | 53.3 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | False |
| 1027 | 4448 | 2224.0 | 98.0 | 49.0 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | False |
| 1028 | 4448 | 2224.0 | 99.1 | 49.5 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | False |
| 1029 | 2223 | 2223.0 | 52.2 | 52.2 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | False |
| 1030 | 4442 | 2221.0 | 82.7 | 41.4 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1031 | 2218 | 2218.0 | 52.5 | 52.5 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | False |
| 1032 | 2216 | 2216.0 | 60.9 | 60.9 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | False |
| 1033 | 2216 | 2216.0 | 65.3 | 65.3 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | False |
| 1034 | 2213 | 2213.0 | 52.2 | 52.2 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1035 | 2211 | 2211.0 | 94.7 | 94.7 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1036 | 4421 | 2210.5 | 120.5 | 60.2 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | False |
| 1037 | 2209 | 2209.0 | 59.3 | 59.3 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1038 | 2209 | 2209.0 | 67.0 | 67.0 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 1039 | 13251 | 2208.5 | 293.5 | 48.9 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1040 | 2207 | 2207.0 | 48.0 | 48.0 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | False |
| 1041 | 2205 | 2205.0 | 56.4 | 56.4 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 1042 | 2204 | 2204.0 | 67.8 | 67.8 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | False |
| 1043 | 2204 | 2204.0 | 91.2 | 91.2 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1044 | 2203 | 2203.0 | 83.8 | 83.8 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | False |
| 1045 | 2202 | 2202.0 | 48.4 | 48.4 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | False |
| 1046 | 2202 | 2202.0 | 55.3 | 55.3 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | False |
| 1047 | 4403 | 2201.5 | 138.6 | 69.3 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
| 1048 | 2200 | 2200.0 | 78.9 | 78.9 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1049 | 2199 | 2199.0 | 71.9 | 71.9 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1050 | 4377 | 2188.5 | 94.4 | 47.2 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 1051 | 2188 | 2188.0 | 39.7 | 39.7 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | False |
| 1052 | 2186 | 2186.0 | 76.2 | 76.2 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | False |
| 1053 | 4370 | 2185.0 | 124.7 | 62.4 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | False |
| 1054 | 24026 | 2184.2 | 583.8 | 53.1 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1055 | 2183 | 2183.0 | 63.6 | 63.6 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 1056 | 4364 | 2182.0 | 148.1 | 74.0 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1057 | 4362 | 2181.0 | 137.4 | 68.7 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 1058 | 4361 | 2180.5 | 161.8 | 80.9 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | False |
| 1059 | 6540 | 2180.0 | 188.5 | 62.8 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1060 | 2179 | 2179.0 | 62.0 | 62.0 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | False |
| 1061 | 6536 | 2178.7 | 165.4 | 55.1 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1062 | 4357 | 2178.5 | 83.4 | 41.7 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | False |
| 1063 | 4345 | 2172.5 | 80.5 | 40.2 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | False |
| 1064 | 2171 | 2171.0 | 53.4 | 53.4 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | False |
| 1065 | 2166 | 2166.0 | 41.6 | 41.6 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | False |
| 1066 | 6490 | 2163.3 | 118.5 | 39.5 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1067 | 2163 | 2163.0 | 64.8 | 64.8 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1068 | 2163 | 2163.0 | 72.2 | 72.2 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | False |
| 1069 | 2161 | 2161.0 | 108.5 | 108.5 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | False |
| 1070 | 4319 | 2159.5 | 93.1 | 46.5 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1071 | 2157 | 2157.0 | 49.6 | 49.6 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | False |
| 1072 | 4314 | 2157.0 | 92.5 | 46.2 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | False |
| 1073 | 2157 | 2157.0 | 87.6 | 87.6 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | False |
| 1074 | 4310 | 2155.0 | 156.1 | 78.0 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | False |
| 1075 | 8618 | 2154.5 | 336.8 | 84.2 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1076 | 4308 | 2154.0 | 100.9 | 50.5 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | False |
| 1077 | 2154 | 2154.0 | 48.5 | 48.5 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | False |
| 1078 | 2152 | 2152.0 | 46.1 | 46.1 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | False |
| 1079 | 2152 | 2152.0 | 31.2 | 31.2 | Sedimentation Studies Of The Size And Shape Of Dna. | F W STUDIER | J Mol Biol | 1965 | 14290352 | Yes |
| 1080 | 2152 | 2152.0 | 63.1 | 63.1 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | False |
| 1081 | 2146 | 2146.0 | 50.9 | 50.9 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | False |
| 1082 | 2146 | 2146.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z DISCHE | J Biol Chem | 1947 | 20281638 | Yes |
| 1083 | 2145 | 2145.0 | 74.7 | 74.7 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | False |
| 1084 | 8576 | 2144.0 | 279.4 | 69.8 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1085 | 4288 | 2144.0 | 106.8 | 53.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | False |
| 1086 | 2144 | 2144.0 | 58.0 | 58.0 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1087 | 4287 | 2143.5 | 132.4 | 66.2 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | False |
| 1088 | 4284 | 2142.0 | 73.0 | 36.5 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H VENABLE, R COGGESHALL | J Cell Biol | 1965 | 14287192 | Yes |
| 1089 | 4281 | 2140.5 | 102.6 | 51.3 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1090 | 2139 | 2139.0 | 42.8 | 42.8 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | False |
| 1091 | 2137 | 2137.0 | 83.9 | 83.9 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1092 | 6411 | 2137.0 | 145.9 | 48.6 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1093 | 2137 | 2137.0 | 41.5 | 41.5 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | False |
| 1094 | 4269 | 2134.5 | 188.8 | 94.4 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1095 | 2134 | 2134.0 | 64.3 | 64.3 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1096 | 2134 | 2134.0 | 42.5 | 42.5 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | False |
| 1097 | 6399 | 2133.0 | 131.1 | 43.7 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1098 | 6396 | 2132.0 | 271.4 | 90.5 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1099 | 4262 | 2131.0 | 81.8 | 40.9 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | False |
| 1100 | 2131 | 2131.0 | 43.4 | 43.4 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | False |
| 1101 | 2131 | 2131.0 | 95.9 | 95.9 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | False |
| 1102 | 2127 | 2127.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O WARBURG | Science | 1956 | 13351639 | Yes |
| 1103 | 2127 | 2127.0 | 50.4 | 50.4 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | False |
| 1104 | 6380 | 2126.7 | 176.0 | 58.7 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1105 | 4253 | 2126.5 | 149.7 | 74.8 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1106 | 4252 | 2126.0 | 121.5 | 60.8 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | False |
| 1107 | 2124 | 2124.0 | 44.2 | 44.2 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | False |
| 1108 | 4247 | 2123.5 | 121.5 | 60.8 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | False |
| 1109 | 4246 | 2123.0 | 181.6 | 90.8 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1110 | 2123 | 2123.0 | 67.7 | 67.7 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | False |
| 1111 | 2122 | 2122.0 | 40.3 | 40.3 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | False |
| 1112 | 4243 | 2121.5 | 110.2 | 55.1 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | False |
| 1113 | 4243 | 2121.5 | 103.6 | 51.8 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | False |
| 1114 | 8485 | 2121.2 | 199.6 | 49.9 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | False |
| 1115 | 4237 | 2118.5 | 36.0 | 18.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F JACOB, J MONOD | J Mol Biol | 1961 | 13718526 | Yes |
| 1116 | 2118 | 2118.0 | 50.5 | 50.5 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1117 | 2118 | 2118.0 | 35.0 | 35.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D AMINOFF | Biochem J | 1961 | 13860975 | Yes |
| 1118 | 4235 | 2117.5 | 93.7 | 46.9 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | False |
| 1119 | 2116 | 2116.0 | 58.3 | 58.3 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | False |
| 1120 | 2114 | 2114.0 | 49.4 | 49.4 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | False |
| 1121 | 6340 | 2113.3 | 202.7 | 67.6 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1122 | 2113 | 2113.0 | 41.8 | 41.8 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | False |
| 1123 | 4221 | 2110.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F BEERS, I W SIZER | J Biol Chem | 1952 | 14938361 | Yes |
| 1124 | 4217 | 2108.5 | 82.4 | 41.2 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | False |
| 1125 | 2108 | 2108.0 | 60.4 | 60.4 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | False |
| 1126 | 2108 | 2108.0 | 83.6 | 83.6 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | False |
| 1127 | 4213 | 2106.5 | 188.5 | 94.2 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | False |
| 1128 | 4210 | 2105.0 | 106.1 | 53.0 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1129 | 2104 | 2104.0 | 49.1 | 49.1 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1130 | 6311 | 2103.7 | 230.4 | 76.8 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 1131 | 2103 | 2103.0 | 65.3 | 65.3 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | False |
| 1132 | 2100 | 2100.0 | 42.6 | 42.6 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | False |
| 1133 | 6299 | 2099.7 | 204.6 | 68.2 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | False |
| 1134 | 4198 | 2099.0 | 82.0 | 41.0 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1135 | 6296 | 2098.7 | 183.2 | 61.1 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1136 | 8393 | 2098.2 | 312.9 | 78.2 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
| 1137 | 2098 | 2098.0 | 64.1 | 64.1 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | False |
| 1138 | 4195 | 2097.5 | 96.6 | 48.3 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | False |
| 1139 | 8370 | 2092.5 | 199.4 | 49.9 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1140 | 2092 | 2092.0 | 43.3 | 43.3 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | False |
| 1141 | 2091 | 2091.0 | 40.5 | 40.5 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | False |
| 1142 | 4180 | 2090.0 | 113.2 | 56.6 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | False |
| 1143 | 2090 | 2090.0 | 58.7 | 58.7 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 1144 | 2085 | 2085.0 | 39.9 | 39.9 | Method For Assay Of Intestinal Disaccharidases. | A DAHLQVIST | Anal Biochem | 1964 | 14106916 | Yes |
| 1145 | 2084 | 2084.0 | 76.7 | 76.7 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | False |
| 1146 | 14586 | 2083.7 | 317.0 | 45.3 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1147 | 2081 | 2081.0 | 49.7 | 49.7 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1148 | 2081 | 2081.0 | 64.6 | 64.6 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | False |
| 1149 | 8323 | 2080.8 | 268.2 | 67.0 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | False |
| 1150 | 2080 | 2080.0 | 98.6 | 98.6 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1151 | 2080 | 2080.0 | 44.2 | 44.2 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | False |
| 1152 | 2079 | 2079.0 | 56.7 | 56.7 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | False |
| 1153 | 4157 | 2078.5 | 80.3 | 40.1 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | False |
| 1154 | 2076 | 2076.0 | 59.3 | 59.3 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1155 | 2076 | 2076.0 | 53.7 | 53.7 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | False |
| 1156 | 4151 | 2075.5 | 114.9 | 57.5 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 1157 | 8286 | 2071.5 | 267.2 | 66.8 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1158 | 2070 | 2070.0 | 52.5 | 52.5 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | False |
| 1159 | 2069 | 2069.0 | 40.3 | 40.3 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | False |
| 1160 | 2069 | 2069.0 | 47.0 | 47.0 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | False |
| 1161 | 4136 | 2068.0 | 110.5 | 55.2 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | False |
| 1162 | 2068 | 2068.0 | 37.3 | 37.3 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C SKOU | Physiol Rev | 1965 | 14337569 | False |
| 1163 | 6204 | 2068.0 | 202.4 | 67.5 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | False |
| 1164 | 2067 | 2067.0 | 65.6 | 65.6 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
| 1165 | 4133 | 2066.5 | 99.1 | 49.5 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1166 | 2066 | 2066.0 | 73.5 | 73.5 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1167 | 2065 | 2065.0 | 42.4 | 42.4 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | False |
| 1168 | 2064 | 2064.0 | 39.3 | 39.3 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | False |
| 1169 | 2064 | 2064.0 | 91.2 | 91.2 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | False |
| 1170 | 2063 | 2063.0 | 70.7 | 70.7 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | False |
| 1171 | 4120 | 2060.0 | 85.7 | 42.9 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1172 | 14417 | 2059.6 | 320.9 | 45.8 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1173 | 2059 | 2059.0 | 39.8 | 39.8 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | False |
| 1174 | 2059 | 2059.0 | 42.2 | 42.2 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | False |
| 1175 | 2059 | 2059.0 | 38.6 | 38.6 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | False |
| 1176 | 4118 | 2059.0 | 120.5 | 60.2 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1177 | 4117 | 2058.5 | 132.9 | 66.5 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | False |
| 1178 | 4116 | 2058.0 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R DULBECCO, M VOGT | J Exp Med | 1954 | 13130792 | Yes |
| 1179 | 2058 | 2058.0 | 22.9 | 22.9 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W CLELAND | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1180 | 4116 | 2058.0 | 159.2 | 79.6 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 1181 | 2055 | 2055.0 | 39.0 | 39.0 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | False |
| 1182 | 2054 | 2054.0 | 48.5 | 48.5 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1183 | 2054 | 2054.0 | 57.5 | 57.5 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | False |
| 1184 | 2053 | 2053.0 | 50.1 | 50.1 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | False |
| 1185 | 4105 | 2052.5 | 95.4 | 47.7 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1186 | 2052 | 2052.0 | 51.7 | 51.7 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | False |
| 1187 | 2052 | 2052.0 | 23.8 | 23.8 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W LITTLEFIELD | Science | 1964 | 14168277 | Yes |
| 1188 | 2051 | 2051.0 | 46.5 | 46.5 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | False |
| 1189 | 4102 | 2051.0 | 166.4 | 83.2 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | False |
| 1190 | 2050 | 2050.0 | 47.4 | 47.4 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | False |
| 1191 | 2049 | 2049.0 | 63.1 | 63.1 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | False |
| 1192 | 12293 | 2048.8 | 365.9 | 61.0 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
| 1193 | 16388 | 2048.5 | 389.6 | 48.7 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1194 | 6142 | 2047.3 | 228.8 | 76.3 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1195 | 2047 | 2047.0 | 84.3 | 84.3 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1196 | 4092 | 2046.0 | 147.6 | 73.8 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | False |
| 1197 | 4090 | 2045.0 | 229.2 | 114.6 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 1198 | 4088 | 2044.0 | 114.7 | 57.4 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | False |
| 1199 | 2040 | 2040.0 | 34.7 | 34.7 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | False |
| 1200 | 6111 | 2037.0 | 196.6 | 65.5 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | False |
| 1201 | 2037 | 2037.0 | 63.6 | 63.6 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | False |
| 1202 | 2036 | 2036.0 | 101.0 | 101.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V NEEL | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1203 | 16281 | 2035.1 | 460.7 | 57.6 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1204 | 10171 | 2034.2 | 321.9 | 64.4 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | False |
| 1205 | 2034 | 2034.0 | 67.2 | 67.2 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1206 | 2033 | 2033.0 | 58.5 | 58.5 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | False |
| 1207 | 2033 | 2033.0 | 63.9 | 63.9 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1208 | 2033 | 2033.0 | 42.9 | 42.9 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | False |
| 1209 | 4062 | 2031.0 | 97.9 | 49.0 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1210 | 2027 | 2027.0 | 47.3 | 47.3 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | False |
| 1211 | 4054 | 2027.0 | 92.3 | 46.1 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1212 | 4051 | 2025.5 | 114.0 | 57.0 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 1213 | 2024 | 2024.0 | 60.3 | 60.3 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | False |
| 1214 | 2023 | 2023.0 | 66.8 | 66.8 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | False |
| 1215 | 2022 | 2022.0 | 52.6 | 52.6 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1216 | 4042 | 2021.0 | 110.3 | 55.1 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1217 | 4042 | 2021.0 | 89.9 | 45.0 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | False |
| 1218 | 2021 | 2021.0 | 78.9 | 78.9 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | False |
| 1219 | 4041 | 2020.5 | 117.1 | 58.5 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | False |
| 1220 | 2019 | 2019.0 | 46.4 | 46.4 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1221 | 2018 | 2018.0 | 36.8 | 36.8 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1222 | 4035 | 2017.5 | 232.9 | 116.5 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1223 | 2017 | 2017.0 | 50.5 | 50.5 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1224 | 4033 | 2016.5 | 154.6 | 77.3 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | False |
| 1225 | 2016 | 2016.0 | 45.6 | 45.6 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | False |
| 1226 | 4032 | 2016.0 | 87.9 | 44.0 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | False |
| 1227 | 4031 | 2015.5 | 81.3 | 40.6 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | False |
| 1228 | 2015 | 2015.0 | 34.5 | 34.5 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | False |
| 1229 | 2015 | 2015.0 | 46.3 | 46.3 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | False |
| 1230 | 4029 | 2014.5 | 124.4 | 62.2 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1231 | 4027 | 2013.5 | 143.7 | 71.8 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | False |
| 1232 | 4027 | 2013.5 | 102.0 | 51.0 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1233 | 2013 | 2013.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A SHOLL | J Anat | 1953 | 13117757 | Yes |
| 1234 | 2013 | 2013.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1235 | 2010 | 2010.0 | 87.8 | 87.8 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1236 | 2010 | 2010.0 | 62.8 | 62.8 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1237 | 2009 | 2009.0 | 41.2 | 41.2 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1238 | 4016 | 2008.0 | 137.8 | 68.9 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1239 | 4008 | 2004.0 | 98.2 | 49.1 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | False |
| 1240 | 4007 | 2003.5 | 141.4 | 70.7 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1241 | 2003 | 2003.0 | 50.6 | 50.6 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | False |
| 1242 | 2003 | 2003.0 | 71.4 | 71.4 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | False |
| 1243 | 4005 | 2002.5 | 85.4 | 42.7 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | False |
| 1244 | 2002 | 2002.0 | 54.9 | 54.9 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | False |
| 1245 | 2002 | 2002.0 | 56.5 | 56.5 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | False |
| 1246 | 2002 | 2002.0 | 76.3 | 76.3 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | False |
| 1247 | 2001 | 2001.0 | 39.1 | 39.1 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | False |
| 1248 | 2000 | 2000.0 | 51.3 | 51.3 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | False |
| 1249 | 2000 | 2000.0 | 58.0 | 58.0 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1250 | 2000 | 2000.0 | 41.5 | 41.5 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | False |
| 1251 | 1999 | 1999.0 | 43.5 | 43.5 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1252 | 3998 | 1999.0 | 135.2 | 67.6 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | Yes |
| 1253 | 1999 | 1999.0 | 54.8 | 54.8 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1254 | 1999 | 1999.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C TOLMAN | Psychol Rev | 1948 | 18870876 | Yes |
| 1255 | 1998 | 1998.0 | 43.3 | 43.3 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | False |
| 1256 | 3994 | 1997.0 | 109.1 | 54.5 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | False |
| 1257 | 3993 | 1996.5 | 86.3 | 43.1 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1258 | 1994 | 1994.0 | 45.4 | 45.4 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1259 | 1993 | 1993.0 | 42.6 | 42.6 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1260 | 1993 | 1993.0 | 63.9 | 63.9 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | False |
| 1261 | 1992 | 1992.0 | 37.9 | 37.9 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | False |
| 1262 | 1991 | 1991.0 | 43.8 | 43.8 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1263 | 3981 | 1990.5 | 138.6 | 69.3 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | False |
| 1264 | 1990 | 1990.0 | 52.7 | 52.7 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | False |
| 1265 | 7953 | 1988.2 | 218.6 | 54.6 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1266 | 1988 | 1988.0 | 40.4 | 40.4 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | False |
| 1267 | 5964 | 1988.0 | 107.3 | 35.8 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1268 | 3975 | 1987.5 | 108.2 | 54.1 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | False |
| 1269 | 1987 | 1987.0 | 82.7 | 82.7 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1270 | 13904 | 1986.3 | 398.8 | 57.0 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1271 | 1986 | 1986.0 | 34.6 | 34.6 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | False |
| 1272 | 7937 | 1984.2 | 186.8 | 46.7 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | False |
| 1273 | 3966 | 1983.0 | 121.0 | 60.5 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1274 | 3961 | 1980.5 | 59.7 | 29.9 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R MORRISON, L M SMITH | J Lipid Res | 1964 | 14221106 | Yes |
| 1275 | 1980 | 1980.0 | 76.0 | 76.0 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1276 | 1980 | 1980.0 | 43.4 | 43.4 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | False |
| 1277 | 1979 | 1979.0 | 39.7 | 39.7 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | False |
| 1278 | 1979 | 1979.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1279 | 3956 | 1978.0 | 95.7 | 47.9 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1280 | 1978 | 1978.0 | 22.6 | 22.6 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1281 | 3954 | 1977.0 | 96.5 | 48.2 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | False |
| 1282 | 1977 | 1977.0 | 50.1 | 50.1 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | False |
| 1283 | 1976 | 1976.0 | 54.6 | 54.6 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | False |
| 1284 | 3950 | 1975.0 | 89.5 | 44.8 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1285 | 3947 | 1973.5 | 123.2 | 61.6 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | False |
| 1286 | 1973 | 1973.0 | 51.8 | 51.8 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | False |
| 1287 | 3944 | 1972.0 | 224.2 | 112.1 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 1288 | 1970 | 1970.0 | 39.8 | 39.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | False |
| 1289 | 1970 | 1970.0 | 39.2 | 39.2 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | False |
| 1290 | 1970 | 1970.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R STEELE | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1291 | 3933 | 1966.5 | 132.7 | 66.3 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | False |
| 1292 | 5899 | 1966.3 | 196.8 | 65.6 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 1293 | 1965 | 1965.0 | 57.6 | 57.6 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | False |
| 1294 | 3929 | 1964.5 | 125.8 | 62.9 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1295 | 7858 | 1964.5 | 304.8 | 76.2 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1296 | 3928 | 1964.0 | 76.5 | 38.2 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
| 1297 | 1962 | 1962.0 | 48.6 | 48.6 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1298 | 3923 | 1961.5 | 94.5 | 47.2 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | False |
| 1299 | 1961 | 1961.0 | 38.7 | 38.7 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1300 | 3920 | 1960.0 | 96.8 | 48.4 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | False |
| 1301 | 1958 | 1958.0 | 51.1 | 51.1 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1302 | 1956 | 1956.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B WOOLF | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1303 | 9770 | 1954.0 | 224.2 | 44.8 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1304 | 5861 | 1953.7 | 192.6 | 64.2 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1305 | 3907 | 1953.5 | 122.3 | 61.1 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | False |
| 1306 | 1953 | 1953.0 | 58.2 | 58.2 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1307 | 3905 | 1952.5 | 114.0 | 57.0 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1308 | 1952 | 1952.0 | 41.2 | 41.2 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | False |
| 1309 | 1952 | 1952.0 | 44.8 | 44.8 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | False |
| 1310 | 1951 | 1951.0 | 55.4 | 55.4 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | False |
| 1311 | 1950 | 1950.0 | 57.6 | 57.6 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1312 | 1950 | 1950.0 | 15.8 | 15.8 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1313 | 5850 | 1950.0 | 200.4 | 66.8 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1314 | 3899 | 1949.5 | 154.0 | 77.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1315 | 3897 | 1948.5 | 84.0 | 42.0 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1316 | 1948 | 1948.0 | 78.4 | 78.4 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | False |
| 1317 | 1948 | 1948.0 | 55.2 | 55.2 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | False |
| 1318 | 1948 | 1948.0 | 58.2 | 58.2 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | False |
| 1319 | 3894 | 1947.0 | 65.7 | 32.9 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1320 | 3894 | 1947.0 | 148.5 | 74.2 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | False |
| 1321 | 5837 | 1945.7 | 147.6 | 49.2 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1322 | 3891 | 1945.5 | 90.0 | 45.0 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | False |
| 1323 | 1945 | 1945.0 | 70.5 | 70.5 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | False |
| 1324 | 3890 | 1945.0 | 75.9 | 38.0 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1325 | 1945 | 1945.0 | 66.0 | 66.0 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1326 | 3889 | 1944.5 | 99.0 | 49.5 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1327 | 1944 | 1944.0 | 50.5 | 50.5 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | False |
| 1328 | 1943 | 1943.0 | 58.6 | 58.6 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1329 | 3886 | 1943.0 | 73.3 | 36.6 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | False |
| 1330 | 5825 | 1941.7 | 119.5 | 39.8 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1331 | 1941 | 1941.0 | 63.3 | 63.3 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | False |
| 1332 | 1941 | 1941.0 | 41.0 | 41.0 | The etiology of chondromalacia patellae. | R E OUTERBRIDGE | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1333 | 1940 | 1940.0 | 42.6 | 42.6 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1334 | 1940 | 1940.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V BOYDEN | J Exp Med | 1951 | 14803635 | Yes |
| 1335 | 1940 | 1940.0 | 50.1 | 50.1 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | False |
| 1336 | 3880 | 1940.0 | 170.9 | 85.5 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | False |
| 1337 | 11638 | 1939.7 | 333.8 | 55.6 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1338 | 3877 | 1938.5 | 79.7 | 39.9 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | False |
| 1339 | 1937 | 1937.0 | 64.1 | 64.1 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1340 | 1935 | 1935.0 | 62.9 | 62.9 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | False |
| 1341 | 1934 | 1934.0 | 33.8 | 33.8 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | False |
| 1342 | 1934 | 1934.0 | 45.8 | 45.8 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | False |
| 1343 | 1933 | 1933.0 | 70.2 | 70.2 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1344 | 1932 | 1932.0 | 63.6 | 63.6 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | False |
| 1345 | 1932 | 1932.0 | 54.0 | 54.0 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | False |
| 1346 | 1931 | 1931.0 | 61.6 | 61.6 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1347 | 1931 | 1931.0 | 45.6 | 45.6 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1348 | 1930 | 1930.0 | 41.9 | 41.9 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | False |
| 1349 | 3858 | 1929.0 | 85.0 | 42.5 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1350 | 3857 | 1928.5 | 102.4 | 51.2 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | False |
| 1351 | 1928 | 1928.0 | 42.3 | 42.3 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | False |
| 1352 | 3853 | 1926.5 | 69.2 | 34.6 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | False |
| 1353 | 3851 | 1925.5 | 133.7 | 66.8 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | False |
| 1354 | 1925 | 1925.0 | 50.3 | 50.3 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | False |
| 1355 | 7695 | 1923.8 | 187.6 | 46.9 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | False |
| 1356 | 11537 | 1922.8 | 333.0 | 55.5 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1357 | 3845 | 1922.5 | 104.4 | 52.2 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | False |
| 1358 | 1922 | 1922.0 | 46.5 | 46.5 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | False |
| 1359 | 1922 | 1922.0 | 45.3 | 45.3 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | False |
| 1360 | 3844 | 1922.0 | 119.5 | 59.8 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | False |
| 1361 | 3841 | 1920.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J VOGEL, D M BONNER | J Biol Chem | 1956 | 13278318 | Yes |
| 1362 | 1920 | 1920.0 | 54.8 | 54.8 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | False |
| 1363 | 1920 | 1920.0 | 47.3 | 47.3 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | False |
| 1364 | 3839 | 1919.5 | 79.2 | 39.6 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1365 | 3838 | 1919.0 | 101.0 | 50.5 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | False |
| 1366 | 13431 | 1918.7 | 472.4 | 67.5 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1367 | 3836 | 1918.0 | 102.1 | 51.0 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | False |
| 1368 | 1916 | 1916.0 | 46.7 | 46.7 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | False |
| 1369 | 1916 | 1916.0 | 41.3 | 41.3 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | False |
| 1370 | 1914 | 1914.0 | 39.8 | 39.8 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1371 | 3827 | 1913.5 | 108.4 | 54.2 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | False |
| 1372 | 3826 | 1913.0 | 94.7 | 47.4 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1373 | 3826 | 1913.0 | 111.8 | 55.9 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1374 | 3822 | 1911.0 | 86.7 | 43.4 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1375 | 1911 | 1911.0 | 50.8 | 50.8 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | False |
| 1376 | 5729 | 1909.7 | 166.6 | 55.5 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | False |
| 1377 | 1909 | 1909.0 | 53.8 | 53.8 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1378 | 1909 | 1909.0 | 40.8 | 40.8 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | False |
| 1379 | 3811 | 1905.5 | 83.5 | 41.8 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | False |
| 1380 | 3809 | 1904.5 | 112.5 | 56.2 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1381 | 7615 | 1903.8 | 318.2 | 79.5 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1382 | 5710 | 1903.3 | 339.1 | 113.0 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1383 | 5705 | 1901.7 | 124.4 | 41.5 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1384 | 1901 | 1901.0 | 52.7 | 52.7 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | False |
| 1385 | 3800 | 1900.0 | 84.8 | 42.4 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1386 | 1900 | 1900.0 | 41.1 | 41.1 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | False |
| 1387 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H HIRS | J Biol Chem | 1956 | 13319283 | Yes |
| 1388 | 1899 | 1899.0 | 50.8 | 50.8 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | False |
| 1389 | 3796 | 1898.0 | 75.3 | 37.6 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1390 | 3794 | 1897.0 | 126.7 | 63.4 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1391 | 1897 | 1897.0 | 63.3 | 63.3 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | False |
| 1392 | 1897 | 1897.0 | 55.0 | 55.0 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | False |
| 1393 | 3793 | 1896.5 | 85.6 | 42.8 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | False |
| 1394 | 1896 | 1896.0 | 51.1 | 51.1 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1395 | 1895 | 1895.0 | 82.4 | 82.4 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | False |
| 1396 | 1893 | 1893.0 | 41.9 | 41.9 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1397 | 1893 | 1893.0 | 46.0 | 46.0 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1398 | 1893 | 1893.0 | 75.8 | 75.8 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | False |
| 1399 | 1891 | 1891.0 | 86.5 | 86.5 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1400 | 3782 | 1891.0 | 124.3 | 62.1 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1401 | 11345 | 1890.8 | 261.0 | 43.5 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1402 | 7555 | 1888.8 | 252.3 | 63.1 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1403 | 1888 | 1888.0 | 61.3 | 61.3 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1404 | 3776 | 1888.0 | 116.0 | 58.0 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1405 | 1888 | 1888.0 | 50.5 | 50.5 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | False |
| 1406 | 1888 | 1888.0 | 39.7 | 39.7 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | False |
| 1407 | 5663 | 1887.7 | 148.9 | 49.6 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1408 | 7542 | 1885.5 | 253.0 | 63.2 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | False |
| 1409 | 5655 | 1885.0 | 167.3 | 55.8 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1410 | 1885 | 1885.0 | 60.4 | 60.4 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1411 | 3770 | 1885.0 | 89.2 | 44.6 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1412 | 1885 | 1885.0 | 49.2 | 49.2 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | False |
| 1413 | 1885 | 1885.0 | 50.5 | 50.5 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | False |
| 1414 | 5653 | 1884.3 | 125.2 | 41.7 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1415 | 1883 | 1883.0 | 37.4 | 37.4 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | False |
| 1416 | 3763 | 1881.5 | 85.4 | 42.7 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | False |
| 1417 | 5644 | 1881.3 | 144.4 | 48.1 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1418 | 1881 | 1881.0 | 73.7 | 73.7 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1419 | 1880 | 1880.0 | 75.3 | 75.3 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | False |
| 1420 | 1880 | 1880.0 | 55.7 | 55.7 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | False |
| 1421 | 13159 | 1879.9 | 354.1 | 50.6 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1422 | 1879 | 1879.0 | 43.8 | 43.8 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | False |
| 1423 | 5629 | 1876.3 | 115.8 | 38.6 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1424 | 1876 | 1876.0 | 49.9 | 49.9 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1425 | 3751 | 1875.5 | 187.3 | 93.7 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1426 | 3751 | 1875.5 | 76.9 | 38.5 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | False |
| 1427 | 1875 | 1875.0 | 67.1 | 67.1 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | False |
| 1428 | 1874 | 1874.0 | 59.9 | 59.9 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | False |
| 1429 | 3746 | 1873.0 | 88.0 | 44.0 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | False |
| 1430 | 5618 | 1872.7 | 242.2 | 80.7 | Shedding light on the cell biology of extracellular vesicles. | Guillaume van Niel, Gisela D'Angelo, Graça Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | False |
| 1431 | 3744 | 1872.0 | 137.6 | 68.8 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1432 | 1871 | 1871.0 | 36.8 | 36.8 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | False |
| 1433 | 1871 | 1871.0 | 70.5 | 70.5 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | False |
| 1434 | 3740 | 1870.0 | 77.1 | 38.5 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1435 | 1869 | 1869.0 | 85.4 | 85.4 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | False |
| 1436 | 5605 | 1868.3 | 139.4 | 46.5 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1437 | 7468 | 1867.0 | 179.1 | 44.8 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1438 | 1867 | 1867.0 | 43.2 | 43.2 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
| 1439 | 1866 | 1866.0 | 19.5 | 19.5 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1440 | 1866 | 1866.0 | 65.7 | 65.7 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1441 | 1866 | 1866.0 | 68.0 | 68.0 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1442 | 1864 | 1864.0 | 48.5 | 48.5 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | False |
| 1443 | 1862 | 1862.0 | 53.9 | 53.9 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | False |
| 1444 | 1862 | 1862.0 | 36.2 | 36.2 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | False |
| 1445 | 1859 | 1859.0 | 35.1 | 35.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | False |
| 1446 | 3717 | 1858.5 | 120.2 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | False |
| 1447 | 1858 | 1858.0 | 52.1 | 52.1 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1448 | 1858 | 1858.0 | 37.2 | 37.2 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1449 | 1858 | 1858.0 | 37.2 | 37.2 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | False |
| 1450 | 3715 | 1857.5 | 78.0 | 39.0 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1451 | 5572 | 1857.3 | 252.4 | 84.1 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1452 | 1857 | 1857.0 | 56.4 | 56.4 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | False |
| 1453 | 1856 | 1856.0 | 44.5 | 44.5 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | False |
| 1454 | 3712 | 1856.0 | 100.3 | 50.1 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | False |
| 1455 | 1856 | 1856.0 | 67.8 | 67.8 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | False |
| 1456 | 1855 | 1855.0 | 70.4 | 70.4 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | False |
| 1457 | 14836 | 1854.5 | 414.8 | 51.9 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1458 | 1854 | 1854.0 | 42.7 | 42.7 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1459 | 1852 | 1852.0 | 57.8 | 57.8 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | False |
| 1460 | 3702 | 1851.0 | 138.1 | 69.0 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1461 | 1848 | 1848.0 | 21.3 | 21.3 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A ROBINSON | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1462 | 1847 | 1847.0 | 66.0 | 66.0 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1463 | 3693 | 1846.5 | 103.4 | 51.7 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1464 | 1846 | 1846.0 | 35.8 | 35.8 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | False |
| 1465 | 5537 | 1845.7 | 102.8 | 34.3 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | False |
| 1466 | 3691 | 1845.5 | 52.4 | 26.2 | Immunoassay of insulin with insulin-antibody precipitate. | C N HALES, P J RANDLE | Biochem J | 1963 | 13952078 | Yes |
| 1467 | 7379 | 1844.8 | 339.3 | 84.8 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1468 | 1844 | 1844.0 | 41.1 | 41.1 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | False |
| 1469 | 1844 | 1844.0 | 54.1 | 54.1 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | False |
| 1470 | 3687 | 1843.5 | 75.0 | 37.5 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | False |
| 1471 | 1843 | 1843.0 | 50.3 | 50.3 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1472 | 9212 | 1842.4 | 330.4 | 66.1 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1473 | 1842 | 1842.0 | 57.3 | 57.3 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1474 | 1842 | 1842.0 | 49.5 | 49.5 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1475 | 1841 | 1841.0 | 53.4 | 53.4 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | False |
| 1476 | 3681 | 1840.5 | 77.0 | 38.5 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1477 | 7360 | 1840.0 | 207.2 | 51.8 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | False |
| 1478 | 1840 | 1840.0 | 49.1 | 49.1 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1479 | 1838 | 1838.0 | 74.5 | 74.5 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | False |
| 1480 | 1838 | 1838.0 | 33.3 | 33.3 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | False |
| 1481 | 9189 | 1837.8 | 235.9 | 47.2 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1482 | 9182 | 1836.4 | 208.7 | 41.7 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1483 | 1835 | 1835.0 | 50.0 | 50.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | False |
| 1484 | 1835 | 1835.0 | 47.2 | 47.2 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | False |
| 1485 | 3669 | 1834.5 | 105.7 | 52.9 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1486 | 1834 | 1834.0 | 67.3 | 67.3 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | False |
| 1487 | 1834 | 1834.0 | 45.4 | 45.4 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | False |
| 1488 | 3668 | 1834.0 | 84.0 | 42.0 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | False |
| 1489 | 1833 | 1833.0 | 42.1 | 42.1 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | False |
| 1490 | 1832 | 1832.0 | 45.5 | 45.5 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | False |
| 1491 | 5495 | 1831.7 | 121.3 | 40.4 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1492 | 5491 | 1830.3 | 113.1 | 37.7 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1493 | 1829 | 1829.0 | 37.4 | 37.4 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | False |
| 1494 | 1829 | 1829.0 | 36.5 | 36.5 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
| 1495 | 1829 | 1829.0 | 71.6 | 71.6 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | False |
| 1496 | 3656 | 1828.0 | 97.4 | 48.7 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | False |
| 1497 | 1828 | 1828.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C SKOU | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1498 | 3655 | 1827.5 | 93.0 | 46.5 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1499 | 1827 | 1827.0 | 33.3 | 33.3 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | False |
| 1500 | 3653 | 1826.5 | 111.7 | 55.9 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | False |
| 1501 | 3653 | 1826.5 | 99.6 | 49.8 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | False |
| 1502 | 1826 | 1826.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D SIMPSON | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1503 | 1824 | 1824.0 | 48.7 | 48.7 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1504 | 1824 | 1824.0 | 33.1 | 33.1 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1505 | 1823 | 1823.0 | 59.9 | 59.9 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | False |
| 1506 | 1823 | 1823.0 | 43.1 | 43.1 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | False |
| 1507 | 1822 | 1822.0 | 59.3 | 59.3 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | False |
| 1508 | 3644 | 1822.0 | 186.0 | 93.0 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1509 | 1822 | 1822.0 | 38.5 | 38.5 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | False |
| 1510 | 7286 | 1821.5 | 139.4 | 34.9 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | False |
| 1511 | 3642 | 1821.0 | 112.8 | 56.4 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1512 | 1820 | 1820.0 | 42.7 | 42.7 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | False |
| 1513 | 1819 | 1819.0 | 89.5 | 89.5 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S COHEN | J Biol Chem | 1962 | 13880319 | Yes |
| 1514 | 1818 | 1818.0 | 67.7 | 67.7 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1515 | 1817 | 1817.0 | 43.4 | 43.4 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1516 | 1816 | 1816.0 | 41.7 | 41.7 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1517 | 5448 | 1816.0 | 120.3 | 40.1 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | False |
| 1518 | 3632 | 1816.0 | 121.8 | 60.9 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | False |
| 1519 | 5441 | 1813.7 | 140.6 | 46.9 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | False |
| 1520 | 1813 | 1813.0 | 45.1 | 45.1 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | False |
| 1521 | 1811 | 1811.0 | 59.1 | 59.1 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1522 | 1810 | 1810.0 | 36.4 | 36.4 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | False |
| 1523 | 1810 | 1810.0 | 46.6 | 46.6 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | False |
| 1524 | 1809 | 1809.0 | 41.7 | 41.7 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | False |
| 1525 | 1809 | 1809.0 | 41.4 | 41.4 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | False |
| 1526 | 1808 | 1808.0 | 53.9 | 53.9 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1527 | 1808 | 1808.0 | 55.9 | 55.9 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | False |
| 1528 | 3615 | 1807.5 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T CAMPBELL, D W FISKE | Psychol Bull | 1959 | 13634291 | Yes |
| 1529 | 1807 | 1807.0 | 62.8 | 62.8 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | False |
| 1530 | 1807 | 1807.0 | 53.2 | 53.2 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | False |
| 1531 | 3613 | 1806.5 | 139.9 | 70.0 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1532 | 3613 | 1806.5 | 94.4 | 47.2 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | False |
| 1533 | 1806 | 1806.0 | 34.1 | 34.1 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | False |
| 1534 | 1804 | 1804.0 | 49.7 | 49.7 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1535 | 9010 | 1802.0 | 217.8 | 43.6 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1536 | 5403 | 1801.0 | 138.9 | 46.3 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1537 | 3598 | 1799.0 | 86.1 | 43.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | False |
| 1538 | 1799 | 1799.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J WHITNEY | J Physiol | 1953 | 13085295 | Yes |
| 1539 | 3595 | 1797.5 | 94.0 | 47.0 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | False |
| 1540 | 1797 | 1797.0 | 37.6 | 37.6 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | False |
| 1541 | 3593 | 1796.5 | 115.2 | 57.6 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | False |
| 1542 | 17963 | 1796.3 | 561.5 | 56.1 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1543 | 1796 | 1796.0 | 95.0 | 95.0 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1544 | 1796 | 1796.0 | 43.4 | 43.4 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | False |
| 1545 | 1796 | 1796.0 | 40.4 | 40.4 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | False |
| 1546 | 1796 | 1796.0 | 54.5 | 54.5 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | False |
| 1547 | 3590 | 1795.0 | 74.9 | 37.5 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | False |
| 1548 | 1795 | 1795.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1549 | 3588 | 1794.0 | 127.9 | 64.0 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1550 | 1794 | 1794.0 | 40.7 | 40.7 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1551 | 1791 | 1791.0 | 42.6 | 42.6 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1552 | 5371 | 1790.3 | 173.8 | 57.9 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1553 | 7161 | 1790.2 | 205.0 | 51.2 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1554 | 1790 | 1790.0 | 43.3 | 43.3 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1555 | 3580 | 1790.0 | 101.2 | 50.6 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 1556 | 3579 | 1789.5 | 133.9 | 67.0 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1557 | 3578 | 1789.0 | 163.4 | 81.7 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | False |
| 1558 | 1788 | 1788.0 | 61.4 | 61.4 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | False |
| 1559 | 1787 | 1787.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S HESTRIN | J Biol Chem | 1949 | 18133390 | Yes |
| 1560 | 3574 | 1787.0 | 163.5 | 81.8 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 1561 | 1786 | 1786.0 | 57.1 | 57.1 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | False |
| 1562 | 1786 | 1786.0 | 79.1 | 79.1 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1563 | 3570 | 1785.0 | 88.5 | 44.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | False |
| 1564 | 1785 | 1785.0 | 40.8 | 40.8 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | False |
| 1565 | 3570 | 1785.0 | 89.6 | 44.8 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1566 | 3569 | 1784.5 | 130.7 | 65.3 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | False |
| 1567 | 1784 | 1784.0 | 54.4 | 54.4 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1568 | 8917 | 1783.4 | 109.0 | 21.8 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE | JAMA | 1963 | 14044222 | Yes |
| 1569 | 1783 | 1783.0 | 37.8 | 37.8 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1570 | 7129 | 1782.2 | 188.9 | 47.2 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 1571 | 1781 | 1781.0 | 58.9 | 58.9 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | False |
| 1572 | 1781 | 1781.0 | 37.4 | 37.4 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | False |
| 1573 | 7124 | 1781.0 | 327.2 | 81.8 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 1574 | 1780 | 1780.0 | 56.1 | 56.1 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1575 | 3559 | 1779.5 | 103.9 | 52.0 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1576 | 3559 | 1779.5 | 127.5 | 63.8 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 1577 | 1779 | 1779.0 | 40.8 | 40.8 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | False |
| 1578 | 3558 | 1779.0 | 88.2 | 44.1 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1579 | 1779 | 1779.0 | 36.0 | 36.0 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1580 | 1779 | 1779.0 | 53.0 | 53.0 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1581 | 1778 | 1778.0 | 51.3 | 51.3 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1582 | 3555 | 1777.5 | 79.7 | 39.9 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | False |
| 1583 | 1777 | 1777.0 | 47.1 | 47.1 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | False |
| 1584 | 1777 | 1777.0 | 46.7 | 46.7 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1585 | 1774 | 1774.0 | 42.7 | 42.7 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | False |
| 1586 | 1774 | 1774.0 | 38.6 | 38.6 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | False |
| 1587 | 1774 | 1774.0 | 19.3 | 19.3 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1588 | 3547 | 1773.5 | 86.3 | 43.1 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | False |
| 1589 | 1773 | 1773.0 | 35.4 | 35.4 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | False |
| 1590 | 1772 | 1772.0 | 51.2 | 51.2 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1591 | 1771 | 1771.0 | 39.0 | 39.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1592 | 1771 | 1771.0 | 41.1 | 41.1 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1593 | 3541 | 1770.5 | 151.9 | 76.0 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1594 | 5310 | 1770.0 | 279.2 | 93.1 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 1595 | 3540 | 1770.0 | 275.1 | 137.6 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | False |
| 1596 | 1769 | 1769.0 | 37.7 | 37.7 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | False |
| 1597 | 3538 | 1769.0 | 151.6 | 75.8 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1598 | 10609 | 1768.2 | 286.3 | 47.7 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1599 | 1768 | 1768.0 | 46.5 | 46.5 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | False |
| 1600 | 3532 | 1766.0 | 105.7 | 52.9 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | False |
| 1601 | 3530 | 1765.0 | 43.8 | 21.9 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1602 | 1765 | 1765.0 | 60.6 | 60.6 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | False |
| 1603 | 1764 | 1764.0 | 58.4 | 58.4 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | False |
| 1604 | 7054 | 1763.5 | 274.2 | 68.5 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1605 | 1763 | 1763.0 | 47.2 | 47.2 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1606 | 3525 | 1762.5 | 224.9 | 112.5 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1607 | 1762 | 1762.0 | 72.4 | 72.4 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | False |
| 1608 | 3524 | 1762.0 | 102.1 | 51.0 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | False |
| 1609 | 3521 | 1760.5 | 140.0 | 70.0 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | False |
| 1610 | 1760 | 1760.0 | 40.1 | 40.1 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | False |
| 1611 | 1759 | 1759.0 | 57.7 | 57.7 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1612 | 1758 | 1758.0 | 39.0 | 39.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
| 1613 | 3514 | 1757.0 | 72.8 | 36.4 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | False |
| 1614 | 3513 | 1756.5 | 92.9 | 46.5 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1615 | 3513 | 1756.5 | 72.8 | 36.4 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1616 | 1756 | 1756.0 | 65.8 | 65.8 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1617 | 1755 | 1755.0 | 62.5 | 62.5 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | False |
| 1618 | 1754 | 1754.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A TAYLOR | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1619 | 3508 | 1754.0 | 102.6 | 51.3 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | False |
| 1620 | 1753 | 1753.0 | 38.4 | 38.4 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | False |
| 1621 | 7011 | 1752.8 | 301.9 | 75.5 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1622 | 3505 | 1752.5 | 81.7 | 40.9 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1623 | 3505 | 1752.5 | 82.3 | 41.1 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 1624 | 1752 | 1752.0 | 21.0 | 21.0 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1625 | 1752 | 1752.0 | 33.2 | 33.2 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1626 | 5254 | 1751.3 | 162.9 | 54.3 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | False |
| 1627 | 1751 | 1751.0 | 60.2 | 60.2 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1628 | 1750 | 1750.0 | 44.3 | 44.3 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | False |
| 1629 | 1750 | 1750.0 | 39.9 | 39.9 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1630 | 1749 | 1749.0 | 37.0 | 37.0 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1631 | 1749 | 1749.0 | 45.0 | 45.0 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1632 | 1749 | 1749.0 | 33.7 | 33.7 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | False |
| 1633 | 5247 | 1749.0 | 119.4 | 39.8 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1634 | 5245 | 1748.3 | 113.9 | 38.0 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1635 | 3496 | 1748.0 | 149.0 | 74.5 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1636 | 1748 | 1748.0 | 60.6 | 60.6 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1637 | 6991 | 1747.8 | 211.8 | 53.0 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1638 | 6986 | 1746.5 | 135.9 | 34.0 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1639 | 3493 | 1746.5 | 85.7 | 42.9 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1640 | 1746 | 1746.0 | 74.1 | 74.1 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | False |
| 1641 | 1746 | 1746.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1642 | 3492 | 1746.0 | 88.2 | 44.1 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | False |
| 1643 | 1746 | 1746.0 | 65.1 | 65.1 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | False |
| 1644 | 1745 | 1745.0 | 64.2 | 64.2 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1645 | 1745 | 1745.0 | 59.3 | 59.3 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | False |
| 1646 | 1745 | 1745.0 | 38.3 | 38.3 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1647 | 3488 | 1744.0 | 223.9 | 112.0 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1648 | 1743 | 1743.0 | 76.4 | 76.4 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1649 | 3485 | 1742.5 | 167.4 | 83.7 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | False |
| 1650 | 1742 | 1742.0 | 41.6 | 41.6 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1651 | 1742 | 1742.0 | 53.6 | 53.6 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | False |
| 1652 | 1741 | 1741.0 | 41.4 | 41.4 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1653 | 3482 | 1741.0 | 67.4 | 33.7 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1654 | 1741 | 1741.0 | 54.1 | 54.1 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | False |
| 1655 | 3481 | 1740.5 | 79.9 | 40.0 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | False |
| 1656 | 1740 | 1740.0 | 52.2 | 52.2 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1657 | 1740 | 1740.0 | 37.9 | 37.9 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | False |
| 1658 | 1739 | 1739.0 | 62.6 | 62.6 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1659 | 5217 | 1739.0 | 121.7 | 40.6 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1660 | 3477 | 1738.5 | 80.1 | 40.0 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | False |
| 1661 | 3476 | 1738.0 | 93.5 | 46.8 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1662 | 3476 | 1738.0 | 125.2 | 62.6 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | False |
| 1663 | 5212 | 1737.3 | 147.6 | 49.2 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallières, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
| 1664 | 3474 | 1737.0 | 109.6 | 54.8 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1665 | 10419 | 1736.5 | 210.3 | 35.1 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1666 | 1736 | 1736.0 | 38.7 | 38.7 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | False |
| 1667 | 1734 | 1734.0 | 31.5 | 31.5 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1668 | 3468 | 1734.0 | 86.3 | 43.1 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1669 | 1734 | 1734.0 | 48.3 | 48.3 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | False |
| 1670 | 1734 | 1734.0 | 39.1 | 39.1 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | False |
| 1671 | 5196 | 1732.0 | 111.1 | 37.0 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | False |
| 1672 | 1732 | 1732.0 | 41.9 | 41.9 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1673 | 1731 | 1731.0 | 62.3 | 62.3 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | False |
| 1674 | 5189 | 1729.7 | 111.7 | 37.2 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1675 | 17295 | 1729.5 | 547.1 | 54.7 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1676 | 3459 | 1729.5 | 71.6 | 35.8 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | False |
| 1677 | 1729 | 1729.0 | 56.2 | 56.2 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1678 | 1729 | 1729.0 | 69.2 | 69.2 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1679 | 1729 | 1729.0 | 38.2 | 38.2 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | False |
| 1680 | 1729 | 1729.0 | 62.7 | 62.7 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1681 | 3457 | 1728.5 | 88.5 | 44.2 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1682 | 1728 | 1728.0 | 38.9 | 38.9 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | False |
| 1683 | 10365 | 1727.5 | 286.4 | 47.7 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1684 | 3453 | 1726.5 | 82.0 | 41.0 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1685 | 1726 | 1726.0 | 58.8 | 58.8 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | False |
| 1686 | 3449 | 1724.5 | 89.6 | 44.8 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | False |
| 1687 | 6898 | 1724.5 | 218.9 | 54.7 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1688 | 1724 | 1724.0 | 57.7 | 57.7 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | False |
| 1689 | 1724 | 1724.0 | 59.6 | 59.6 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1690 | 8618 | 1723.6 | 415.4 | 83.1 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 1691 | 1723 | 1723.0 | 52.4 | 52.4 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1692 | 1722 | 1722.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H SELYE | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1693 | 3443 | 1721.5 | 68.5 | 34.2 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | False |
| 1694 | 5164 | 1721.3 | 230.9 | 77.0 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1695 | 1720 | 1720.0 | 44.4 | 44.4 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | False |
| 1696 | 1719 | 1719.0 | 31.4 | 31.4 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | False |
| 1697 | 1718 | 1718.0 | 32.7 | 32.7 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1698 | 3435 | 1717.5 | 71.0 | 35.5 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
| 1699 | 5151 | 1717.0 | 274.3 | 91.4 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1700 | 1716 | 1716.0 | 41.9 | 41.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1701 | 5147 | 1715.7 | 201.7 | 67.2 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1702 | 1715 | 1715.0 | 31.3 | 31.3 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | False |
| 1703 | 1714 | 1714.0 | 73.7 | 73.7 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1704 | 1714 | 1714.0 | 68.0 | 68.0 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1705 | 1714 | 1714.0 | 35.8 | 35.8 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | False |
| 1706 | 1714 | 1714.0 | 47.1 | 47.1 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | False |
| 1707 | 3427 | 1713.5 | 79.0 | 39.5 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | False |
| 1708 | 1712 | 1712.0 | 65.3 | 65.3 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | False |
| 1709 | 6848 | 1712.0 | 143.7 | 35.9 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1710 | 1712 | 1712.0 | 35.9 | 35.9 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | False |
| 1711 | 3424 | 1712.0 | 99.0 | 49.5 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | False |
| 1712 | 18828 | 1711.6 | 474.9 | 43.2 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1713 | 1711 | 1711.0 | 44.2 | 44.2 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | False |
| 1714 | 1711 | 1711.0 | 17.1 | 17.1 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1715 | 1711 | 1711.0 | 85.3 | 85.3 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | False |
| 1716 | 1710 | 1710.0 | 33.5 | 33.5 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | False |
| 1717 | 3418 | 1709.0 | 82.4 | 41.2 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1718 | 3418 | 1709.0 | 96.1 | 48.0 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1719 | 1708 | 1708.0 | 45.1 | 45.1 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | False |
| 1720 | 1707 | 1707.0 | 51.8 | 51.8 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | False |
| 1721 | 3414 | 1707.0 | 69.9 | 35.0 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | False |
| 1722 | 3413 | 1706.5 | 49.7 | 24.9 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J KARNOVSKY, L ROOTS | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1723 | 1705 | 1705.0 | 39.7 | 39.7 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | False |
| 1724 | 1702 | 1702.0 | 72.8 | 72.8 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1725 | 3404 | 1702.0 | 96.5 | 48.2 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1726 | 3402 | 1701.0 | 86.3 | 43.1 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1727 | 1700 | 1700.0 | 42.7 | 42.7 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | False |
| 1728 | 1700 | 1700.0 | 44.7 | 44.7 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1729 | 1700 | 1700.0 | 30.7 | 30.7 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | False |
| 1730 | 1699 | 1699.0 | 45.8 | 45.8 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | False |
| 1731 | 3395 | 1697.5 | 91.5 | 45.8 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | False |
| 1732 | 3394 | 1697.0 | 81.1 | 40.5 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1733 | 3393 | 1696.5 | 110.6 | 55.3 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | False |
| 1734 | 3390 | 1695.0 | 74.0 | 37.0 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | False |
| 1735 | 3389 | 1694.5 | 125.8 | 62.9 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1736 | 1694 | 1694.0 | 47.8 | 47.8 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | False |
| 1737 | 1692 | 1692.0 | 45.0 | 45.0 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | False |
| 1738 | 1692 | 1692.0 | 39.9 | 39.9 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1739 | 1692 | 1692.0 | 32.9 | 32.9 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | False |
| 1740 | 1692 | 1692.0 | 38.4 | 38.4 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | False |
| 1741 | 1691 | 1691.0 | 83.0 | 83.0 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
| 1742 | 1691 | 1691.0 | 29.3 | 29.3 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H MOLLENHAUER | Stain Technol | 1964 | 14127791 | Yes |
| 1743 | 3380 | 1690.0 | 93.0 | 46.5 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | False |
| 1744 | 1690 | 1690.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J RANKIN | Scott Med J | 1957 | 13432835 | Yes |
| 1745 | 3379 | 1689.5 | 66.6 | 33.3 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | False |
| 1746 | 3377 | 1688.5 | 129.8 | 64.9 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1747 | 3376 | 1688.0 | 78.8 | 39.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | False |
| 1748 | 1688 | 1688.0 | 40.1 | 40.1 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | False |
| 1749 | 3374 | 1687.0 | 65.0 | 32.5 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | False |
| 1750 | 3373 | 1686.5 | 93.1 | 46.5 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1751 | 1686 | 1686.0 | 62.4 | 62.4 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | False |
| 1752 | 1685 | 1685.0 | 55.0 | 55.0 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | False |
| 1753 | 1685 | 1685.0 | 0.0 | 0.0 | A new readability yardstick. | R FLESCH | J Appl Psychol | 1948 | 18867058 | Yes |
| 1754 | 1684 | 1684.0 | 58.5 | 58.5 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | False |
| 1755 | 3368 | 1684.0 | 75.4 | 37.7 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1756 | 3367 | 1683.5 | 77.6 | 38.8 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | False |
| 1757 | 1683 | 1683.0 | 52.8 | 52.8 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | False |
| 1758 | 1683 | 1683.0 | 45.4 | 45.4 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | False |
| 1759 | 3365 | 1682.5 | 110.1 | 55.0 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | False |
| 1760 | 1682 | 1682.0 | 31.1 | 31.1 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | False |
| 1761 | 1682 | 1682.0 | 30.1 | 30.1 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | False |
| 1762 | 1682 | 1682.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G GRAY | J Anat | 1959 | 13829103 | Yes |
| 1763 | 1681 | 1681.0 | 37.6 | 37.6 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | False |
| 1764 | 6723 | 1680.8 | 236.3 | 59.1 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 1765 | 1679 | 1679.0 | 40.8 | 40.8 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1766 | 15111 | 1679.0 | 460.1 | 51.1 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | False |
| 1767 | 1678 | 1678.0 | 73.5 | 73.5 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1768 | 1678 | 1678.0 | 35.1 | 35.1 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | False |
| 1769 | 5034 | 1678.0 | 96.5 | 32.2 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1770 | 1678 | 1678.0 | 17.8 | 17.8 | Chromatographic Separation Of Human Brain Gangliosides. | L SVENNERHOLM | J Neurochem | 1963 | 14066623 | Yes |
| 1771 | 1678 | 1678.0 | 37.7 | 37.7 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | False |
| 1772 | 10063 | 1677.2 | 230.5 | 38.4 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1773 | 3354 | 1677.0 | 84.7 | 42.4 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | False |
| 1774 | 1677 | 1677.0 | 64.5 | 64.5 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | False |
| 1775 | 1676 | 1676.0 | 42.8 | 42.8 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | False |
| 1776 | 1676 | 1676.0 | 38.2 | 38.2 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | False |
| 1777 | 5028 | 1676.0 | 118.2 | 39.4 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | False |
| 1778 | 3351 | 1675.5 | 102.7 | 51.4 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | False |
| 1779 | 1675 | 1675.0 | 42.9 | 42.9 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | False |
| 1780 | 3350 | 1675.0 | 71.7 | 35.9 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | False |
| 1781 | 1675 | 1675.0 | 70.9 | 70.9 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | False |
| 1782 | 1674 | 1674.0 | 22.5 | 22.5 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1783 | 1674 | 1674.0 | 58.5 | 58.5 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | False |
| 1784 | 1674 | 1674.0 | 32.1 | 32.1 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | False |
| 1785 | 1674 | 1674.0 | 46.2 | 46.2 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 1786 | 1673 | 1673.0 | 43.2 | 43.2 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1787 | 1673 | 1673.0 | 36.9 | 36.9 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 1788 | 3344 | 1672.0 | 91.1 | 45.5 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | False |
| 1789 | 3343 | 1671.5 | 194.0 | 97.0 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1790 | 1671 | 1671.0 | 56.3 | 56.3 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | False |
| 1791 | 1670 | 1670.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1792 | 8349 | 1669.8 | 346.6 | 69.3 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 1793 | 5009 | 1669.7 | 128.3 | 42.8 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1794 | 1669 | 1669.0 | 72.2 | 72.2 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 1795 | 3338 | 1669.0 | 69.4 | 34.7 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1796 | 1669 | 1669.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A LASSEN | Physiol Rev | 1959 | 13645234 | Yes |
| 1797 | 1668 | 1668.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F BOAS | J Biol Chem | 1953 | 13117829 | Yes |
| 1798 | 1667 | 1667.0 | 50.6 | 50.6 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1799 | 1666 | 1666.0 | 54.5 | 54.5 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | False |
| 1800 | 1666 | 1666.0 | 40.2 | 40.2 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | False |
| 1801 | 1666 | 1666.0 | 45.0 | 45.0 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1802 | 3331 | 1665.5 | 54.3 | 27.1 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T OMURA, R SATO | J Biol Chem | 1964 | 14209972 | Yes |
| 1803 | 1664 | 1664.0 | 48.5 | 48.5 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1804 | 1664 | 1664.0 | 82.8 | 82.8 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | False |
| 1805 | 1663 | 1663.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S KETY | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1806 | 9977 | 1662.8 | 343.7 | 57.3 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1807 | 3324 | 1662.0 | 111.1 | 55.5 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 1808 | 3323 | 1661.5 | 97.8 | 48.9 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1809 | 1661 | 1661.0 | 49.1 | 49.1 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1810 | 1661 | 1661.0 | 37.0 | 37.0 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | False |
| 1811 | 3322 | 1661.0 | 126.3 | 63.1 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 1812 | 3320 | 1660.0 | 60.5 | 30.2 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1813 | 1660 | 1660.0 | 31.7 | 31.7 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | False |
| 1814 | 1660 | 1660.0 | 33.7 | 33.7 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | False |
| 1815 | 1659 | 1659.0 | 46.9 | 46.9 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1816 | 1659 | 1659.0 | 58.8 | 58.8 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1817 | 1659 | 1659.0 | 41.6 | 41.6 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | False |
| 1818 | 6634 | 1658.5 | 152.3 | 38.1 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1819 | 3315 | 1657.5 | 70.0 | 35.0 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 1820 | 1657 | 1657.0 | 52.7 | 52.7 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | False |
| 1821 | 1657 | 1657.0 | 39.2 | 39.2 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | False |
| 1822 | 1657 | 1657.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P MORAN | Biometrika | 1950 | 15420245 | Yes |
| 1823 | 6628 | 1657.0 | 252.8 | 63.2 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 1824 | 3313 | 1656.5 | 83.9 | 42.0 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1825 | 3311 | 1655.5 | 64.1 | 32.0 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | False |
| 1826 | 3311 | 1655.5 | 110.8 | 55.4 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | False |
| 1827 | 1654 | 1654.0 | 49.0 | 49.0 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | False |
| 1828 | 1654 | 1654.0 | 40.1 | 40.1 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | False |
| 1829 | 1654 | 1654.0 | 44.7 | 44.7 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | False |
| 1830 | 1654 | 1654.0 | 69.4 | 69.4 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 1831 | 1653 | 1653.0 | 32.2 | 32.2 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1832 | 4956 | 1652.0 | 108.8 | 36.3 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M G Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1833 | 1652 | 1652.0 | 90.5 | 90.5 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | False |
| 1834 | 3302 | 1651.0 | 71.2 | 35.6 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1835 | 1651 | 1651.0 | 46.7 | 46.7 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | False |
| 1836 | 3301 | 1650.5 | 80.5 | 40.2 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 1837 | 1650 | 1650.0 | 37.9 | 37.9 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | False |
| 1838 | 1650 | 1650.0 | 61.7 | 61.7 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1839 | 3298 | 1649.0 | 80.8 | 40.4 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | False |
| 1840 | 1648 | 1648.0 | 30.6 | 30.6 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | False |
| 1841 | 1648 | 1648.0 | 53.3 | 53.3 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1842 | 3295 | 1647.5 | 70.5 | 35.2 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | False |
| 1843 | 1647 | 1647.0 | 56.7 | 56.7 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | False |
| 1844 | 1647 | 1647.0 | 37.3 | 37.3 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | False |
| 1845 | 1647 | 1647.0 | 34.9 | 34.9 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | False |
| 1846 | 1647 | 1647.0 | 49.0 | 49.0 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | False |
| 1847 | 1646 | 1646.0 | 53.4 | 53.4 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1848 | 1646 | 1646.0 | 33.3 | 33.3 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | False |
| 1849 | 1646 | 1646.0 | 31.3 | 31.3 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1850 | 1646 | 1646.0 | 34.6 | 34.6 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | False |
| 1851 | 3292 | 1646.0 | 69.7 | 34.9 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | False |
| 1852 | 3291 | 1645.5 | 85.4 | 42.7 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1853 | 4933 | 1644.3 | 135.3 | 45.1 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1854 | 1644 | 1644.0 | 48.3 | 48.3 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | False |
| 1855 | 1644 | 1644.0 | 45.0 | 45.0 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | False |
| 1856 | 1643 | 1643.0 | 68.8 | 68.8 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | False |
| 1857 | 1641 | 1641.0 | 23.0 | 23.0 | Structural considerations in the interaction of DNA and acridines. | L S LERMAN | J Mol Biol | 1961 | 13761054 | Yes |
| 1858 | 1641 | 1641.0 | 169.9 | 169.9 | Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. | Brent R Stockwell | Cell | 2022 | 35803244 | False |
| 1859 | 3281 | 1640.5 | 71.8 | 35.9 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | False |
| 1860 | 1640 | 1640.0 | 36.5 | 36.5 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | False |
| 1861 | 1640 | 1640.0 | 77.3 | 77.3 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | False |
| 1862 | 3279 | 1639.5 | 97.8 | 48.9 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | False |
| 1863 | 1639 | 1639.0 | 28.7 | 28.7 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 1864 | 1639 | 1639.0 | 36.3 | 36.3 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | Yes |
| 1865 | 1638 | 1638.0 | 45.1 | 45.1 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 1866 | 1637 | 1637.0 | 46.6 | 46.6 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | False |
| 1867 | 3274 | 1637.0 | 96.6 | 48.3 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 1868 | 1637 | 1637.0 | 34.7 | 34.7 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | False |
| 1869 | 6547 | 1636.8 | 155.5 | 38.9 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1870 | 1636 | 1636.0 | 27.6 | 27.6 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | False |
| 1871 | 1636 | 1636.0 | 36.7 | 36.7 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | False |
| 1872 | 4907 | 1635.7 | 117.8 | 39.3 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1873 | 1635 | 1635.0 | 62.9 | 62.9 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1874 | 1634 | 1634.0 | 39.3 | 39.3 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | False |
| 1875 | 1634 | 1634.0 | 101.5 | 101.5 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D MATTINGLY | J Clin Pathol | 1962 | 14471419 | Yes |
| 1876 | 1633 | 1633.0 | 37.2 | 37.2 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1877 | 1631 | 1631.0 | 51.0 | 51.0 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | False |
| 1878 | 1631 | 1631.0 | 41.1 | 41.1 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | False |
| 1879 | 3262 | 1631.0 | 69.2 | 34.6 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | False |
| 1880 | 1630 | 1630.0 | 70.9 | 70.9 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1881 | 3260 | 1630.0 | 66.2 | 33.1 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | False |
| 1882 | 3260 | 1630.0 | 65.7 | 32.9 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1883 | 9780 | 1630.0 | 223.7 | 37.3 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 1884 | 1629 | 1629.0 | 49.7 | 49.7 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | False |
| 1885 | 1629 | 1629.0 | 56.3 | 56.3 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | False |
| 1886 | 3258 | 1629.0 | 182.9 | 91.5 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J MARMUR, P DOTY | J Mol Biol | 1962 | 14470099 | Yes |
| 1887 | 1628 | 1628.0 | 71.8 | 71.8 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | False |
| 1888 | 1627 | 1627.0 | 47.1 | 47.1 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | False |
| 1889 | 3254 | 1627.0 | 58.8 | 29.4 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | False |
| 1890 | 3252 | 1626.0 | 76.5 | 38.2 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1891 | 1626 | 1626.0 | 58.1 | 58.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | False |
| 1892 | 1626 | 1626.0 | 40.4 | 40.4 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | False |
| 1893 | 1626 | 1626.0 | 38.8 | 38.8 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | False |
| 1894 | 1626 | 1626.0 | 49.4 | 49.4 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | False |
| 1895 | 1625 | 1625.0 | 33.3 | 33.3 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | False |
| 1896 | 3248 | 1624.0 | 77.3 | 38.6 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | False |
| 1897 | 1623 | 1623.0 | 45.6 | 45.6 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 1898 | 1623 | 1623.0 | 31.1 | 31.1 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | False |
| 1899 | 1623 | 1623.0 | 43.8 | 43.8 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | False |
| 1900 | 1623 | 1623.0 | 38.9 | 38.9 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1901 | 1622 | 1622.0 | 30.1 | 30.1 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | False |
| 1902 | 4866 | 1622.0 | 103.1 | 34.4 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | False |
| 1903 | 3244 | 1622.0 | 81.0 | 40.5 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 1904 | 3243 | 1621.5 | 74.2 | 37.1 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | False |
| 1905 | 1621 | 1621.0 | 30.3 | 30.3 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | False |
| 1906 | 3242 | 1621.0 | 67.0 | 33.5 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | False |
| 1907 | 1620 | 1620.0 | 34.0 | 34.0 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | False |
| 1908 | 1620 | 1620.0 | 30.2 | 30.2 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | False |
| 1909 | 1619 | 1619.0 | 29.9 | 29.9 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | False |
| 1910 | 1619 | 1619.0 | 31.4 | 31.4 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1911 | 1618 | 1618.0 | 47.4 | 47.4 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | False |
| 1912 | 3236 | 1618.0 | 80.4 | 40.2 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | False |
| 1913 | 1617 | 1617.0 | 42.5 | 42.5 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1914 | 1616 | 1616.0 | 71.8 | 71.8 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | False |
| 1915 | 3232 | 1616.0 | 92.8 | 46.4 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | False |
| 1916 | 1615 | 1615.0 | 50.9 | 50.9 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | False |
| 1917 | 1615 | 1615.0 | 62.2 | 62.2 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | False |
| 1918 | 1615 | 1615.0 | 42.8 | 42.8 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 1919 | 1614 | 1614.0 | 111.8 | 111.8 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 1920 | 4842 | 1614.0 | 122.3 | 40.8 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1921 | 1614 | 1614.0 | 34.6 | 34.6 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | False |
| 1922 | 4841 | 1613.7 | 162.0 | 54.0 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | False |
| 1923 | 3227 | 1613.5 | 62.2 | 31.1 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 1924 | 3227 | 1613.5 | 103.5 | 51.8 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | False |
| 1925 | 1613 | 1613.0 | 40.4 | 40.4 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | False |
| 1926 | 1613 | 1613.0 | 46.0 | 46.0 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | False |
| 1927 | 1613 | 1613.0 | 28.3 | 28.3 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | False |
| 1928 | 1612 | 1612.0 | 34.3 | 34.3 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | False |
| 1929 | 1612 | 1612.0 | 33.6 | 33.6 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | False |
| 1930 | 1612 | 1612.0 | 29.9 | 29.9 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | False |
| 1931 | 1612 | 1612.0 | 35.7 | 35.7 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | False |
| 1932 | 3224 | 1612.0 | 92.1 | 46.0 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | False |
| 1933 | 3223 | 1611.5 | 90.9 | 45.5 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1934 | 3223 | 1611.5 | 91.8 | 45.9 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 1935 | 3221 | 1610.5 | 67.2 | 33.6 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | False |
| 1936 | 4828 | 1609.3 | 122.9 | 41.0 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | False |
| 1937 | 1609 | 1609.0 | 37.6 | 37.6 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | False |
| 1938 | 3217 | 1608.5 | 74.0 | 37.0 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1939 | 4825 | 1608.3 | 115.6 | 38.5 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 1940 | 1607 | 1607.0 | 28.9 | 28.9 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | False |
| 1941 | 1607 | 1607.0 | 49.2 | 49.2 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | False |
| 1942 | 1607 | 1607.0 | 29.4 | 29.4 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | False |
| 1943 | 1607 | 1607.0 | 29.2 | 29.2 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 1944 | 1607 | 1607.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W KUFFLER | J Neurophysiol | 1953 | 13035466 | Yes |
| 1945 | 1606 | 1606.0 | 42.6 | 42.6 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | False |
| 1946 | 1605 | 1605.0 | 46.5 | 46.5 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | False |
| 1947 | 1605 | 1605.0 | 36.7 | 36.7 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | False |
| 1948 | 3209 | 1604.5 | 113.1 | 56.5 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 1949 | 3209 | 1604.5 | 78.0 | 39.0 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | False |
| 1950 | 1604 | 1604.0 | 52.1 | 52.1 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | False |
| 1951 | 1604 | 1604.0 | 63.2 | 63.2 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 1952 | 4812 | 1604.0 | 134.7 | 44.9 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 1953 | 3208 | 1604.0 | 70.1 | 35.0 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | False |
| 1954 | 1604 | 1604.0 | 26.1 | 26.1 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | False |
| 1955 | 3207 | 1603.5 | 61.3 | 30.6 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 1956 | 3207 | 1603.5 | 78.0 | 39.0 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 1957 | 3205 | 1602.5 | 87.9 | 44.0 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | False |
| 1958 | 1602 | 1602.0 | 29.4 | 29.4 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | False |
| 1959 | 1602 | 1602.0 | 19.5 | 19.5 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W CLELAND | Biochemistry | 1964 | 14192894 | Yes |
| 1960 | 1601 | 1601.0 | 36.1 | 36.1 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | False |
| 1961 | 3200 | 1600.0 | 110.7 | 55.4 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 1962 | 3200 | 1600.0 | 67.1 | 33.5 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | False |
| 1963 | 1600 | 1600.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 1964 | 7999 | 1599.8 | 287.9 | 57.6 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | False |
| 1965 | 3199 | 1599.5 | 91.3 | 45.6 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | False |
| 1966 | 1599 | 1599.0 | 39.4 | 39.4 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 1967 | 3198 | 1599.0 | 65.1 | 32.5 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | False |
| 1968 | 3198 | 1599.0 | 81.0 | 40.5 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 1969 | 1599 | 1599.0 | 43.8 | 43.8 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | False |
| 1970 | 3197 | 1598.5 | 59.9 | 29.9 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 1971 | 1598 | 1598.0 | 36.6 | 36.6 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | False |
| 1972 | 3196 | 1598.0 | 77.4 | 38.7 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 1973 | 1597 | 1597.0 | 31.3 | 31.3 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | False |
| 1974 | 1596 | 1596.0 | 51.9 | 51.9 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 1975 | 1596 | 1596.0 | 74.6 | 74.6 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1976 | 4786 | 1595.3 | 294.9 | 98.3 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 1977 | 9571 | 1595.2 | 278.6 | 46.4 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 1978 | 1595 | 1595.0 | 69.4 | 69.4 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | False |
| 1979 | 3189 | 1594.5 | 192.8 | 96.4 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 1980 | 1594 | 1594.0 | 32.6 | 32.6 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | False |
| 1981 | 1594 | 1594.0 | 38.3 | 38.3 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 1982 | 4780 | 1593.3 | 88.3 | 29.4 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | False |
| 1983 | 1593 | 1593.0 | 49.2 | 49.2 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 1984 | 3182 | 1591.0 | 57.1 | 28.6 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | False |
| 1985 | 1591 | 1591.0 | 31.3 | 31.3 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | False |
| 1986 | 15905 | 1590.5 | 374.3 | 37.4 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 1987 | 9541 | 1590.2 | 308.0 | 51.3 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 1988 | 1590 | 1590.0 | 35.3 | 35.3 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | False |
| 1989 | 1590 | 1590.0 | 44.5 | 44.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 1990 | 1590 | 1590.0 | 34.2 | 34.2 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | False |
| 1991 | 4769 | 1589.7 | 93.6 | 31.2 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 1992 | 4769 | 1589.7 | 59.6 | 19.9 | Improved method for the determination of blood glutathione. | E BEUTLER, O DURON, B M KELLY | J Lab Clin Med | 1963 | 13967893 | Yes |
| 1993 | 1589 | 1589.0 | 42.8 | 42.8 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | False |
| 1994 | 1588 | 1588.0 | 48.5 | 48.5 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 1995 | 3175 | 1587.5 | 91.1 | 45.5 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | False |
| 1996 | 1587 | 1587.0 | 50.1 | 50.1 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 1997 | 4760 | 1586.7 | 91.8 | 30.6 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 1998 | 3173 | 1586.5 | 63.2 | 31.6 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 1999 | 7931 | 1586.2 | 371.3 | 74.3 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 2000 | 1586 | 1586.0 | 49.4 | 49.4 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | False |
| 2001 | 3171 | 1585.5 | 96.3 | 48.1 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 2002 | 3171 | 1585.5 | 82.7 | 41.4 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | False |
| 2003 | 1585 | 1585.0 | 37.6 | 37.6 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 2004 | 3170 | 1585.0 | 60.4 | 30.2 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 2005 | 4751 | 1583.7 | 130.0 | 43.3 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 2006 | 3167 | 1583.5 | 101.0 | 50.5 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | False |
| 2007 | 7915 | 1583.0 | 153.3 | 30.7 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 2008 | 1582 | 1582.0 | 50.5 | 50.5 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2009 | 1580 | 1580.0 | 35.2 | 35.2 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | False |
| 2010 | 3159 | 1579.5 | 62.6 | 31.3 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | False |
| 2011 | 3159 | 1579.5 | 63.3 | 31.6 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | False |
| 2012 | 1579 | 1579.0 | 41.5 | 41.5 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | False |
| 2013 | 1578 | 1578.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C HUMMEL | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 2014 | 4734 | 1578.0 | 121.3 | 40.4 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2015 | 3155 | 1577.5 | 67.1 | 33.5 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2016 | 1577 | 1577.0 | 52.7 | 52.7 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | False |
| 2017 | 3153 | 1576.5 | 77.6 | 38.8 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | False |
| 2018 | 1576 | 1576.0 | 33.9 | 33.9 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | False |
| 2019 | 3149 | 1574.5 | 91.8 | 45.9 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 2020 | 1574 | 1574.0 | 65.1 | 65.1 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | False |
| 2021 | 1574 | 1574.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H EAGLE | Science | 1955 | 13255879 | Yes |
| 2022 | 1573 | 1573.0 | 50.0 | 50.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2023 | 3144 | 1572.0 | 121.2 | 60.6 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | False |
| 2024 | 3144 | 1572.0 | 189.4 | 94.7 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | False |
| 2025 | 3143 | 1571.5 | 61.7 | 30.9 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | False |
| 2026 | 1571 | 1571.0 | 79.7 | 79.7 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 2027 | 1571 | 1571.0 | 44.8 | 44.8 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | False |
| 2028 | 1571 | 1571.0 | 46.6 | 46.6 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2029 | 1571 | 1571.0 | 54.9 | 54.9 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2030 | 1570 | 1570.0 | 61.7 | 61.7 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2031 | 1570 | 1570.0 | 80.6 | 80.6 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2032 | 1570 | 1570.0 | 31.3 | 31.3 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | False |
| 2033 | 3140 | 1570.0 | 76.3 | 38.1 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2034 | 4707 | 1569.0 | 156.0 | 52.0 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | False |
| 2035 | 3135 | 1567.5 | 76.8 | 38.4 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | False |
| 2036 | 4701 | 1567.0 | 114.4 | 38.1 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | False |
| 2037 | 1567 | 1567.0 | 33.2 | 33.2 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | False |
| 2038 | 3133 | 1566.5 | 89.2 | 44.6 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 2039 | 1566 | 1566.0 | 58.8 | 58.8 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | False |
| 2040 | 3132 | 1566.0 | 71.7 | 35.9 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | False |
| 2041 | 1566 | 1566.0 | 51.1 | 51.1 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 2042 | 1565 | 1565.0 | 55.6 | 55.6 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | False |
| 2043 | 3127 | 1563.5 | 113.1 | 56.5 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | False |
| 2044 | 3124 | 1562.0 | 77.7 | 38.9 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2045 | 1562 | 1562.0 | 60.5 | 60.5 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | False |
| 2046 | 3123 | 1561.5 | 105.2 | 52.6 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2047 | 20296 | 1561.2 | 513.6 | 39.5 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2048 | 1561 | 1561.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 2049 | 3120 | 1560.0 | 79.6 | 39.8 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 2050 | 1560 | 1560.0 | 41.1 | 41.1 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | False |
| 2051 | 4679 | 1559.7 | 170.1 | 56.7 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 2052 | 6230 | 1557.5 | 118.9 | 29.7 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2053 | 3115 | 1557.5 | 29.5 | 14.8 | Junctional complexes in various epithelia. | M G FARQUHAR, G E PALADE | J Cell Biol | 1963 | 13944428 | Yes |
| 2054 | 3114 | 1557.0 | 38.5 | 19.2 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 2055 | 1556 | 1556.0 | 42.2 | 42.2 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | False |
| 2056 | 4667 | 1555.7 | 128.6 | 42.9 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | False |
| 2057 | 4665 | 1555.0 | 103.1 | 34.4 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 2058 | 1554 | 1554.0 | 49.1 | 49.1 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | False |
| 2059 | 7769 | 1553.8 | 277.2 | 55.4 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 2060 | 3106 | 1553.0 | 67.8 | 33.9 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | False |
| 2061 | 1552 | 1552.0 | 38.3 | 38.3 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | False |
| 2062 | 1552 | 1552.0 | 56.7 | 56.7 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2063 | 1551 | 1551.0 | 43.8 | 43.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | False |
| 2064 | 1551 | 1551.0 | 32.1 | 32.1 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 2065 | 1551 | 1551.0 | 65.0 | 65.0 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 2066 | 6203 | 1550.8 | 207.8 | 52.0 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 2067 | 1550 | 1550.0 | 44.8 | 44.8 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | False |
| 2068 | 1550 | 1550.0 | 32.6 | 32.6 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | False |
| 2069 | 1550 | 1550.0 | 59.1 | 59.1 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | False |
| 2070 | 6198 | 1549.5 | 153.4 | 38.4 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2071 | 12395 | 1549.4 | 303.4 | 37.9 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2072 | 1549 | 1549.0 | 38.4 | 38.4 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2073 | 1549 | 1549.0 | 28.0 | 28.0 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | False |
| 2074 | 1548 | 1548.0 | 54.2 | 54.2 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | False |
| 2075 | 1547 | 1547.0 | 38.6 | 38.6 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | False |
| 2076 | 4640 | 1546.7 | 140.4 | 46.8 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2077 | 1545 | 1545.0 | 31.4 | 31.4 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | False |
| 2078 | 4632 | 1544.0 | 89.2 | 29.7 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 2079 | 1544 | 1544.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L WELCH | Biometrika | 1947 | 20287819 | Yes |
| 2080 | 1544 | 1544.0 | 45.8 | 45.8 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | False |
| 2081 | 1543 | 1543.0 | 33.0 | 33.0 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | False |
| 2082 | 1543 | 1543.0 | 46.9 | 46.9 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 2083 | 3085 | 1542.5 | 71.1 | 35.5 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 2084 | 1541 | 1541.0 | 42.8 | 42.8 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | False |
| 2085 | 1541 | 1541.0 | 44.7 | 44.7 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 2086 | 1541 | 1541.0 | 42.3 | 42.3 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | False |
| 2087 | 1539 | 1539.0 | 53.5 | 53.5 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2088 | 1539 | 1539.0 | 43.1 | 43.1 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2089 | 1538 | 1538.0 | 50.9 | 50.9 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | False |
| 2090 | 6151 | 1537.8 | 177.4 | 44.4 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2091 | 4612 | 1537.3 | 90.7 | 30.2 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2092 | 1537 | 1537.0 | 90.8 | 90.8 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2093 | 1537 | 1537.0 | 30.0 | 30.0 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2094 | 1537 | 1537.0 | 45.8 | 45.8 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | False |
| 2095 | 3074 | 1537.0 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G SCHMIDT, S J THANNHAUSER | J Biol Chem | 1945 | 21005717 | Yes |
| 2096 | 1536 | 1536.0 | 57.7 | 57.7 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2097 | 10745 | 1535.0 | 226.7 | 32.4 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2098 | 1535 | 1535.0 | 31.9 | 31.9 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | False |
| 2099 | 3070 | 1535.0 | 113.7 | 56.9 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | False |
| 2100 | 1534 | 1534.0 | 18.8 | 18.8 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2101 | 1534 | 1534.0 | 40.2 | 40.2 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | False |
| 2102 | 4600 | 1533.3 | 96.3 | 32.1 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | False |
| 2103 | 1533 | 1533.0 | 59.3 | 59.3 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2104 | 1533 | 1533.0 | 33.8 | 33.8 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2105 | 1533 | 1533.0 | 44.6 | 44.6 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2106 | 1532 | 1532.0 | 35.9 | 35.9 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | False |
| 2107 | 1531 | 1531.0 | 57.1 | 57.1 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2108 | 1531 | 1531.0 | 37.5 | 37.5 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2109 | 1531 | 1531.0 | 57.0 | 57.0 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2110 | 1530 | 1530.0 | 41.0 | 41.0 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | False |
| 2111 | 6120 | 1530.0 | 146.9 | 36.7 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2112 | 1530 | 1530.0 | 88.4 | 88.4 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 2113 | 3059 | 1529.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
| 2114 | 1529 | 1529.0 | 50.2 | 50.2 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2115 | 3058 | 1529.0 | 88.7 | 44.4 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | False |
| 2116 | 1529 | 1529.0 | 36.6 | 36.6 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | False |
| 2117 | 1528 | 1528.0 | 33.4 | 33.4 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | False |
| 2118 | 1528 | 1528.0 | 21.3 | 21.3 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2119 | 1528 | 1528.0 | 31.4 | 31.4 | Antigen-Antibody Crossed Electrophoresis. | C B LAURELL | Anal Biochem | 1965 | 14302464 | Yes |
| 2120 | 3055 | 1527.5 | 59.7 | 29.9 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | False |
| 2121 | 1527 | 1527.0 | 67.8 | 67.8 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2122 | 1527 | 1527.0 | 39.3 | 39.3 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | False |
| 2123 | 1527 | 1527.0 | 32.4 | 32.4 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | False |
| 2124 | 3053 | 1526.5 | 66.7 | 33.4 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | False |
| 2125 | 1526 | 1526.0 | 50.2 | 50.2 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2126 | 10682 | 1526.0 | 255.9 | 36.6 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 2127 | 4578 | 1526.0 | 149.0 | 49.7 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graça Raposo, Clotilde Théry | Annu Rev Cell Dev Biol | 2014 | 25288114 | False |
| 2128 | 6103 | 1525.8 | 253.4 | 63.4 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | False |
| 2129 | 3049 | 1524.5 | 98.5 | 49.2 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | False |
| 2130 | 3049 | 1524.5 | 94.3 | 47.1 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | False |
| 2131 | 1523 | 1523.0 | 38.7 | 38.7 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | False |
| 2132 | 1523 | 1523.0 | 43.9 | 43.9 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | False |
| 2133 | 1522 | 1522.0 | 45.2 | 45.2 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2134 | 1522 | 1522.0 | 48.1 | 48.1 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | False |
| 2135 | 6088 | 1522.0 | 202.7 | 50.7 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 2136 | 1521 | 1521.0 | 45.6 | 45.6 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2137 | 1521 | 1521.0 | 47.9 | 47.9 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2138 | 1521 | 1521.0 | 40.8 | 40.8 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | False |
| 2139 | 1521 | 1521.0 | 33.2 | 33.2 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | False |
| 2140 | 4561 | 1520.3 | 93.7 | 31.2 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | False |
| 2141 | 4560 | 1520.0 | 165.5 | 55.2 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2142 | 3039 | 1519.5 | 95.1 | 47.5 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | False |
| 2143 | 1519 | 1519.0 | 43.6 | 43.6 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2144 | 1518 | 1518.0 | 56.9 | 56.9 | Inflammation, metaflammation and immunometabolic disorders. | Gökhan S Hotamisligil | Nature | 2017 | 28179656 | False |
| 2145 | 3035 | 1517.5 | 59.9 | 29.9 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | False |
| 2146 | 1517 | 1517.0 | 40.0 | 40.0 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2147 | 1517 | 1517.0 | 37.9 | 37.9 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | False |
| 2148 | 1517 | 1517.0 | 97.3 | 97.3 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2149 | 6068 | 1517.0 | 130.4 | 32.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2150 | 4549 | 1516.3 | 109.8 | 36.6 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | False |
| 2151 | 1516 | 1516.0 | 26.9 | 26.9 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2152 | 4548 | 1516.0 | 153.4 | 51.1 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2153 | 1516 | 1516.0 | 56.5 | 56.5 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
| 2154 | 1516 | 1516.0 | 65.1 | 65.1 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | False |
| 2155 | 1515 | 1515.0 | 12.3 | 12.3 | The Relation Of Recombination To Mutational Advance. | H J MULLER | Mutat Res | 1964 | 14195748 | Yes |
| 2156 | 1515 | 1515.0 | 35.3 | 35.3 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | False |
| 2157 | 1514 | 1514.0 | 26.4 | 26.4 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | False |
| 2158 | 1514 | 1514.0 | 29.1 | 29.1 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L RAMANATHAN | J Appl Physiol | 1964 | 14173555 | Yes |
| 2159 | 1513 | 1513.0 | 40.8 | 40.8 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | False |
| 2160 | 3023 | 1511.5 | 88.0 | 44.0 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | False |
| 2161 | 3022 | 1511.0 | 58.5 | 29.2 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | False |
| 2162 | 1510 | 1510.0 | 42.6 | 42.6 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2163 | 1510 | 1510.0 | 45.4 | 45.4 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2164 | 1510 | 1510.0 | 39.9 | 39.9 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2165 | 3018 | 1509.0 | 89.6 | 44.8 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2166 | 1509 | 1509.0 | 83.2 | 83.2 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | False |
| 2167 | 6034 | 1508.5 | 196.4 | 49.1 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 2168 | 4525 | 1508.3 | 140.6 | 46.9 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2169 | 1508 | 1508.0 | 38.4 | 38.4 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | False |
| 2170 | 1508 | 1508.0 | 41.0 | 41.0 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | False |
| 2171 | 1507 | 1507.0 | 33.7 | 33.7 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2172 | 1507 | 1507.0 | 25.6 | 25.6 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K FUXE | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2173 | 1507 | 1507.0 | 115.7 | 115.7 | The changing landscape of atherosclerosis. | Peter Libby | Nature | 2021 | 33883728 | False |
| 2174 | 1506 | 1506.0 | 40.5 | 40.5 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | False |
| 2175 | 1506 | 1506.0 | 96.9 | 96.9 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2176 | 1506 | 1506.0 | 44.3 | 44.3 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2177 | 1506 | 1506.0 | 39.5 | 39.5 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2178 | 1505 | 1505.0 | 49.2 | 49.2 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | False |
| 2179 | 1505 | 1505.0 | 35.1 | 35.1 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | False |
| 2180 | 3010 | 1505.0 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F WROBLEWSKI, J S LADUE | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2181 | 4514 | 1504.7 | 101.5 | 33.8 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | False |
| 2182 | 3009 | 1504.5 | 58.4 | 29.2 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | False |
| 2183 | 1504 | 1504.0 | 22.1 | 22.1 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2184 | 1504 | 1504.0 | 46.6 | 46.6 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | False |
| 2185 | 1504 | 1504.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2186 | 3008 | 1504.0 | 122.8 | 61.4 | Interpreting findings from Mendelian randomization using the MR-Egger method. | Stephen Burgess, Simon G Thompson | Eur J Epidemiol | 2017 | 28527048 | Yes |
| 2187 | 3007 | 1503.5 | 97.1 | 48.5 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | False |
| 2188 | 4509 | 1503.0 | 259.7 | 86.6 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A WINTER, E A RISLEY, G W NUSS | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2189 | 1503 | 1503.0 | 45.5 | 45.5 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | False |
| 2190 | 1502 | 1502.0 | 19.1 | 19.1 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2191 | 1501 | 1501.0 | 31.8 | 31.8 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2192 | 4501 | 1500.3 | 97.0 | 32.3 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2193 | 1500 | 1500.0 | 32.8 | 32.8 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | False |
| 2194 | 1500 | 1500.0 | 52.0 | 52.0 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | False |
| 2195 | 2998 | 1499.0 | 92.6 | 46.3 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | False |
| 2196 | 1498 | 1498.0 | 43.2 | 43.2 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | False |
| 2197 | 1497 | 1497.0 | 44.5 | 44.5 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | False |
| 2198 | 1497 | 1497.0 | 17.8 | 17.8 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | False |
| 2199 | 2992 | 1496.0 | 61.6 | 30.8 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | False |
| 2200 | 2992 | 1496.0 | 56.6 | 28.3 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | False |
| 2201 | 1496 | 1496.0 | 36.0 | 36.0 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | False |
| 2202 | 2991 | 1495.5 | 98.1 | 49.0 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2203 | 2991 | 1495.5 | 100.1 | 50.0 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | False |
| 2204 | 4486 | 1495.3 | 103.4 | 34.5 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | False |
| 2205 | 1495 | 1495.0 | 56.7 | 56.7 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2206 | 2990 | 1495.0 | 84.3 | 42.1 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2207 | 1495 | 1495.0 | 33.5 | 33.5 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | False |
| 2208 | 1495 | 1495.0 | 53.4 | 53.4 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 2209 | 5978 | 1494.5 | 263.5 | 65.9 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 2210 | 2988 | 1494.0 | 101.8 | 50.9 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2211 | 2988 | 1494.0 | 56.7 | 28.4 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | False |
| 2212 | 1494 | 1494.0 | 36.9 | 36.9 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | False |
| 2213 | 1494 | 1494.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B MOUNTCASTLE | J Neurophysiol | 1957 | 13439410 | Yes |
| 2214 | 2987 | 1493.5 | 93.7 | 46.9 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 2215 | 1493 | 1493.0 | 45.9 | 45.9 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | False |
| 2216 | 1493 | 1493.0 | 38.2 | 38.2 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2217 | 1493 | 1493.0 | 51.8 | 51.8 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | False |
| 2218 | 1492 | 1492.0 | 11.8 | 11.8 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W SPERRY | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2219 | 1491 | 1491.0 | 39.0 | 39.0 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | False |
| 2220 | 1490 | 1490.0 | 49.7 | 49.7 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2221 | 1490 | 1490.0 | 34.3 | 34.3 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | False |
| 2222 | 1490 | 1490.0 | 44.6 | 44.6 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | False |
| 2223 | 1490 | 1490.0 | 43.8 | 43.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | False |
| 2224 | 1489 | 1489.0 | 36.3 | 36.3 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | False |
| 2225 | 1489 | 1489.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2226 | 4466 | 1488.7 | 53.5 | 17.8 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T DODGE, C MITCHELL, D J HANAHAN | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2227 | 1488 | 1488.0 | 33.8 | 33.8 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | False |
| 2228 | 1488 | 1488.0 | 36.4 | 36.4 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2229 | 1488 | 1488.0 | 42.1 | 42.1 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | False |
| 2230 | 2975 | 1487.5 | 69.9 | 35.0 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2231 | 2975 | 1487.5 | 114.9 | 57.5 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | False |
| 2232 | 4462 | 1487.3 | 141.8 | 47.3 | SCANPY: large-scale single-cell gene expression data analysis. | F Alexander Wolf, Philipp Angerer, Fabian J Theis | Genome Biol | 2018 | 29409532 | Yes |
| 2233 | 7436 | 1487.2 | 326.6 | 65.3 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 2234 | 1486 | 1486.0 | 38.2 | 38.2 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | False |
| 2235 | 1485 | 1485.0 | 33.2 | 33.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2236 | 1485 | 1485.0 | 39.2 | 39.2 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | False |
| 2237 | 1484 | 1484.0 | 34.8 | 34.8 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2238 | 1484 | 1484.0 | 26.3 | 26.3 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2239 | 1484 | 1484.0 | 28.4 | 28.4 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | False |
| 2240 | 5933 | 1483.2 | 247.4 | 61.9 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2241 | 1483 | 1483.0 | 40.5 | 40.5 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | False |
| 2242 | 4448 | 1482.7 | 106.5 | 35.5 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2243 | 4448 | 1482.7 | 156.3 | 52.1 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | False |
| 2244 | 2962 | 1481.0 | 75.3 | 37.6 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2245 | 1481 | 1481.0 | 62.3 | 62.3 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | False |
| 2246 | 1481 | 1481.0 | 50.5 | 50.5 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2247 | 1481 | 1481.0 | 36.6 | 36.6 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | False |
| 2248 | 2962 | 1481.0 | 85.3 | 42.6 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | False |
| 2249 | 13325 | 1480.6 | 408.4 | 45.4 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2250 | 2961 | 1480.5 | 70.6 | 35.3 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | False |
| 2251 | 1480 | 1480.0 | 78.2 | 78.2 | Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. | Cynthia Rudin | Nat Mach Intell | 2019 | 35603010 | Yes |
| 2252 | 1479 | 1479.0 | 48.5 | 48.5 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2253 | 1479 | 1479.0 | 40.9 | 40.9 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | False |
| 2254 | 2958 | 1479.0 | 76.8 | 38.4 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | False |
| 2255 | 2957 | 1478.5 | 96.4 | 48.2 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | False |
| 2256 | 1477 | 1477.0 | 31.4 | 31.4 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | False |
| 2257 | 1477 | 1477.0 | 31.7 | 31.7 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | False |
| 2258 | 1477 | 1477.0 | 14.3 | 14.3 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E HUXLEY | J Mol Biol | 1963 | 14064165 | Yes |
| 2259 | 1477 | 1477.0 | 39.8 | 39.8 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | False |
| 2260 | 2953 | 1476.5 | 68.1 | 34.0 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | False |
| 2261 | 1476 | 1476.0 | 25.3 | 25.3 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | False |
| 2262 | 1476 | 1476.0 | 30.5 | 30.5 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | False |
| 2263 | 2951 | 1475.5 | 67.2 | 33.6 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | False |
| 2264 | 1475 | 1475.0 | 34.3 | 34.3 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C NOWELL | Cancer Res | 1960 | 14427849 | Yes |
| 2265 | 2950 | 1475.0 | 94.7 | 47.4 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | False |
| 2266 | 1475 | 1475.0 | 58.4 | 58.4 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2267 | 1475 | 1475.0 | 52.1 | 52.1 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2268 | 1474 | 1474.0 | 37.4 | 37.4 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | False |
| 2269 | 2947 | 1473.5 | 76.1 | 38.0 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | False |
| 2270 | 1473 | 1473.0 | 33.7 | 33.7 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | False |
| 2271 | 2945 | 1472.5 | 81.1 | 40.5 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2272 | 2945 | 1472.5 | 158.2 | 79.1 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G GRAY, V P WHITTAKER | J Anat | 1962 | 13901297 | Yes |
| 2273 | 2945 | 1472.5 | 75.4 | 37.7 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | False |
| 2274 | 2944 | 1472.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2275 | 1471 | 1471.0 | 52.7 | 52.7 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2276 | 1471 | 1471.0 | 42.8 | 42.8 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | False |
| 2277 | 1471 | 1471.0 | 47.7 | 47.7 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | False |
| 2278 | 1471 | 1471.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2279 | 1471 | 1471.0 | 51.1 | 51.1 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2280 | 2941 | 1470.5 | 67.9 | 34.0 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | False |
| 2281 | 1470 | 1470.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H ROSEN | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2282 | 4409 | 1469.7 | 121.1 | 40.4 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2283 | 2939 | 1469.5 | 95.7 | 47.9 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2284 | 1469 | 1469.0 | 30.4 | 30.4 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2285 | 1469 | 1469.0 | 32.9 | 32.9 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | False |
| 2286 | 1469 | 1469.0 | 76.7 | 76.7 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | False |
| 2287 | 1468 | 1468.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E SATTERTHWAITE | Biometrics | 1946 | 20287815 | Yes |
| 2288 | 1468 | 1468.0 | 34.4 | 34.4 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | False |
| 2289 | 1467 | 1467.0 | 35.5 | 35.5 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2290 | 1467 | 1467.0 | 47.8 | 47.8 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2291 | 4400 | 1466.7 | 95.8 | 31.9 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2292 | 10260 | 1465.7 | 338.0 | 48.3 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 2293 | 1465 | 1465.0 | 37.0 | 37.0 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | False |
| 2294 | 1465 | 1465.0 | 51.1 | 51.1 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | False |
| 2295 | 1464 | 1464.0 | 33.5 | 33.5 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J KARNOVSKY | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2296 | 2927 | 1463.5 | 91.6 | 45.8 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | False |
| 2297 | 1463 | 1463.0 | 37.9 | 37.9 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2298 | 1463 | 1463.0 | 34.4 | 34.4 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2299 | 1463 | 1463.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2300 | 2924 | 1462.0 | 99.4 | 49.7 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2301 | 2920 | 1460.0 | 152.8 | 76.4 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2302 | 1460 | 1460.0 | 53.0 | 53.0 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2303 | 1460 | 1460.0 | 30.0 | 30.0 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | False |
| 2304 | 2919 | 1459.5 | 77.2 | 38.6 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | False |
| 2305 | 1459 | 1459.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E BUSH | Biochem J | 1952 | 14915960 | Yes |
| 2306 | 2918 | 1459.0 | 67.2 | 33.6 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | False |
| 2307 | 1458 | 1458.0 | 20.8 | 20.8 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2308 | 1458 | 1458.0 | 38.1 | 38.1 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | False |
| 2309 | 2915 | 1457.5 | 101.7 | 50.9 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2310 | 1457 | 1457.0 | 38.1 | 38.1 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2311 | 7284 | 1456.8 | 264.7 | 52.9 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | False |
| 2312 | 1456 | 1456.0 | 54.1 | 54.1 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | False |
| 2313 | 1456 | 1456.0 | 41.1 | 41.1 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | False |
| 2314 | 4367 | 1455.7 | 144.3 | 48.1 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2315 | 2911 | 1455.5 | 54.0 | 27.0 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | False |
| 2316 | 2910 | 1455.0 | 86.0 | 43.0 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | False |
| 2317 | 2909 | 1454.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H CLARKE, J CASALS | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2318 | 4363 | 1454.3 | 92.4 | 30.8 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | False |
| 2319 | 1454 | 1454.0 | 36.4 | 36.4 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | False |
| 2320 | 1454 | 1454.0 | 25.7 | 25.7 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | False |
| 2321 | 2907 | 1453.5 | 55.1 | 27.6 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | False |
| 2322 | 2906 | 1453.0 | 75.3 | 37.6 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2323 | 1453 | 1453.0 | 43.9 | 43.9 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2324 | 1453 | 1453.0 | 29.1 | 29.1 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | False |
| 2325 | 1453 | 1453.0 | 40.1 | 40.1 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2326 | 1453 | 1453.0 | 49.5 | 49.5 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | False |
| 2327 | 5809 | 1452.2 | 232.1 | 58.0 | Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. | Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess | Genet Epidemiol | 2016 | 27061298 | Yes |
| 2328 | 1452 | 1452.0 | 33.5 | 33.5 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | False |
| 2329 | 2903 | 1451.5 | 79.5 | 39.8 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2330 | 2903 | 1451.5 | 55.0 | 27.5 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | False |
| 2331 | 2902 | 1451.0 | 85.7 | 42.9 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2332 | 1450 | 1450.0 | 35.6 | 35.6 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2333 | 1450 | 1450.0 | 30.5 | 30.5 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | False |
| 2334 | 4349 | 1449.7 | 254.9 | 85.0 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 2335 | 1449 | 1449.0 | 48.4 | 48.4 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2336 | 1449 | 1449.0 | 36.6 | 36.6 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | False |
| 2337 | 1449 | 1449.0 | 38.6 | 38.6 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | False |
| 2338 | 2898 | 1449.0 | 81.1 | 40.5 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2339 | 2895 | 1447.5 | 62.6 | 31.3 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | False |
| 2340 | 2894 | 1447.0 | 78.3 | 39.1 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | False |
| 2341 | 2894 | 1447.0 | 65.9 | 33.0 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2342 | 5786 | 1446.5 | 152.7 | 38.2 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2343 | 2893 | 1446.5 | 87.7 | 43.9 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2344 | 4339 | 1446.3 | 150.1 | 50.0 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2345 | 4334 | 1444.7 | 94.3 | 31.4 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2346 | 2889 | 1444.5 | 63.0 | 31.5 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | False |
| 2347 | 2888 | 1444.0 | 57.0 | 28.5 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2348 | 2888 | 1444.0 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D DAVIS, E S MINGIOLI | J Bacteriol | 1950 | 15436457 | Yes |
| 2349 | 1443 | 1443.0 | 34.7 | 34.7 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2350 | 2886 | 1443.0 | 79.8 | 39.9 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2351 | 1443 | 1443.0 | 32.8 | 32.8 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | False |
| 2352 | 1443 | 1443.0 | 36.2 | 36.2 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | False |
| 2353 | 2884 | 1442.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A ISAACS, J LINDENMANN | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2354 | 2884 | 1442.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J BLOOM, W W RICHARDSON | Br J Cancer | 1957 | 13499785 | Yes |
| 2355 | 2884 | 1442.0 | 174.6 | 87.3 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H ANTON, D F SAYRE | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2356 | 7206 | 1441.2 | 154.6 | 30.9 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2357 | 1441 | 1441.0 | 41.1 | 41.1 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2358 | 4323 | 1441.0 | 85.8 | 28.6 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | False |
| 2359 | 2881 | 1440.5 | 52.7 | 26.4 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | False |
| 2360 | 2881 | 1440.5 | 66.5 | 33.2 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | False |
| 2361 | 2879 | 1439.5 | 70.3 | 35.1 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2362 | 2879 | 1439.5 | 84.8 | 42.4 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2363 | 2879 | 1439.5 | 106.2 | 53.1 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | False |
| 2364 | 1439 | 1439.0 | 37.0 | 37.0 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | False |
| 2365 | 1439 | 1439.0 | 31.2 | 31.2 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | False |
| 2366 | 2878 | 1439.0 | 75.7 | 37.9 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | False |
| 2367 | 1439 | 1439.0 | 41.2 | 41.2 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2368 | 4314 | 1438.0 | 134.5 | 44.8 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2369 | 4310 | 1436.7 | 86.8 | 28.9 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | False |
| 2370 | 1436 | 1436.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D POULIK | Nature | 1957 | 13493570 | Yes |
| 2371 | 1436 | 1436.0 | 41.0 | 41.0 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2372 | 2871 | 1435.5 | 95.2 | 47.6 | Nitric oxide synthases: regulation and function. | Ulrich Förstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | False |
| 2373 | 1435 | 1435.0 | 27.4 | 27.4 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | False |
| 2374 | 7175 | 1435.0 | 203.7 | 40.7 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2375 | 1435 | 1435.0 | 28.9 | 28.9 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | False |
| 2376 | 4302 | 1434.0 | 88.7 | 29.6 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | False |
| 2377 | 1434 | 1434.0 | 33.2 | 33.2 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2378 | 4301 | 1433.7 | 114.0 | 38.0 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2379 | 2865 | 1432.5 | 70.4 | 35.2 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2380 | 1432 | 1432.0 | 32.6 | 32.6 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | False |
| 2381 | 1432 | 1432.0 | 31.2 | 31.2 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | False |
| 2382 | 2864 | 1432.0 | 95.4 | 47.7 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | False |
| 2383 | 1432 | 1432.0 | 61.4 | 61.4 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 2384 | 1431 | 1431.0 | 26.5 | 26.5 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | False |
| 2385 | 2862 | 1431.0 | 70.4 | 35.2 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2386 | 4292 | 1430.7 | 202.0 | 67.3 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2387 | 10015 | 1430.7 | 399.7 | 57.1 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2388 | 1430 | 1430.0 | 16.5 | 16.5 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J WYMAN | Adv Protein Chem | 1964 | 14268785 | False |
| 2389 | 2860 | 1430.0 | 80.4 | 40.2 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | False |
| 2390 | 7148 | 1429.6 | 254.6 | 50.9 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 2391 | 1429 | 1429.0 | 84.9 | 84.9 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2392 | 2858 | 1429.0 | 65.8 | 32.9 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | False |
| 2393 | 4286 | 1428.7 | 91.8 | 30.6 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2394 | 2857 | 1428.5 | 70.0 | 35.0 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2395 | 1428 | 1428.0 | 30.8 | 30.8 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2396 | 5710 | 1427.5 | 205.2 | 51.3 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2397 | 1427 | 1427.0 | 46.1 | 46.1 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2398 | 2854 | 1427.0 | 71.1 | 35.5 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2399 | 2854 | 1427.0 | 67.6 | 33.8 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | False |
| 2400 | 7135 | 1427.0 | 166.7 | 33.3 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2401 | 2853 | 1426.5 | 180.5 | 90.2 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. | Helmut Sies, Dean P Jones | Nat Rev Mol Cell Biol | 2020 | 32231263 | False |
| 2402 | 1426 | 1426.0 | 16.9 | 16.9 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2403 | 4278 | 1426.0 | 106.9 | 35.6 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2404 | 1426 | 1426.0 | 33.1 | 33.1 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | False |
| 2405 | 1425 | 1425.0 | 30.7 | 30.7 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2406 | 1425 | 1425.0 | 34.3 | 34.3 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | False |
| 2407 | 1425 | 1425.0 | 42.1 | 42.1 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2408 | 4274 | 1424.7 | 139.8 | 46.6 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2409 | 2849 | 1424.5 | 83.0 | 41.5 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | False |
| 2410 | 5698 | 1424.5 | 134.1 | 33.5 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | False |
| 2411 | 4273 | 1424.3 | 99.4 | 33.1 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2412 | 1424 | 1424.0 | 53.8 | 53.8 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2413 | 1424 | 1424.0 | 29.7 | 29.7 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2414 | 1424 | 1424.0 | 12.8 | 12.8 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2415 | 2848 | 1424.0 | 61.8 | 30.9 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2416 | 1424 | 1424.0 | 42.6 | 42.6 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2417 | 1424 | 1424.0 | 41.8 | 41.8 | Function and information content of DNA methylation. | Dirk Schübeler | Nature | 2015 | 25592537 | False |
| 2418 | 2847 | 1423.5 | 88.9 | 44.5 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2419 | 4269 | 1423.0 | 330.4 | 110.1 | Ferroptosis: mechanisms, biology and role in disease. | Xuejun Jiang, Brent R Stockwell, Marcus Conrad | Nat Rev Mol Cell Biol | 2021 | 33495651 | False |
| 2420 | 2845 | 1422.5 | 36.4 | 18.2 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A DAHLSTROEM, K FUXE | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2421 | 2845 | 1422.5 | 110.3 | 55.1 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | Yes |
| 2422 | 8533 | 1422.2 | 211.4 | 35.2 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2423 | 2844 | 1422.0 | 73.6 | 36.8 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 2424 | 1422 | 1422.0 | 33.1 | 33.1 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | False |
| 2425 | 1422 | 1422.0 | 39.2 | 39.2 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2426 | 2844 | 1422.0 | 97.8 | 48.9 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | False |
| 2427 | 1421 | 1421.0 | 50.4 | 50.4 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2428 | 1421 | 1421.0 | 0.0 | 0.0 | The critical incident technique. | J C FLANAGAN | Psychol Bull | 1954 | 13177800 | Yes |
| 2429 | 1420 | 1420.0 | 66.9 | 66.9 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2430 | 1420 | 1420.0 | 44.0 | 44.0 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | False |
| 2431 | 2840 | 1420.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L HODGKIN, B KATZ | J Physiol | 1949 | 18128147 | Yes |
| 2432 | 2839 | 1419.5 | 77.3 | 38.6 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | False |
| 2433 | 1419 | 1419.0 | 58.3 | 58.3 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2434 | 1419 | 1419.0 | 42.8 | 42.8 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | False |
| 2435 | 1419 | 1419.0 | 59.2 | 59.2 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | False |
| 2436 | 1418 | 1418.0 | 29.2 | 29.2 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2437 | 2835 | 1417.5 | 58.7 | 29.4 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | False |
| 2438 | 1416 | 1416.0 | 47.4 | 47.4 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2439 | 1416 | 1416.0 | 39.9 | 39.9 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | False |
| 2440 | 1415 | 1415.0 | 50.9 | 50.9 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | False |
| 2441 | 2829 | 1414.5 | 81.0 | 40.5 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2442 | 2829 | 1414.5 | 77.3 | 38.6 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | False |
| 2443 | 1414 | 1414.0 | 30.3 | 30.3 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | False |
| 2444 | 1413 | 1413.0 | 33.3 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | False |
| 2445 | 2825 | 1412.5 | 65.8 | 32.9 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | False |
| 2446 | 1412 | 1412.0 | 25.3 | 25.3 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2447 | 1412 | 1412.0 | 24.4 | 24.4 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | False |
| 2448 | 2824 | 1412.0 | 79.5 | 39.8 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2449 | 1412 | 1412.0 | 36.4 | 36.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2450 | 2824 | 1412.0 | 79.1 | 39.5 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marçais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 2451 | 2824 | 1412.0 | 104.2 | 52.1 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | False |
| 2452 | 1412 | 1412.0 | 70.3 | 70.3 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2453 | 2823 | 1411.5 | 95.3 | 47.6 | A new scale of social desirability independent of psychopathology. | D P CROWNE, D MARLOWE | J Consult Psychol | 1960 | 13813058 | Yes |
| 2454 | 2818 | 1409.0 | 71.0 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2455 | 1409 | 1409.0 | 26.8 | 26.8 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | False |
| 2456 | 2818 | 1409.0 | 82.5 | 41.2 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2457 | 2815 | 1407.5 | 81.2 | 40.6 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | False |
| 2458 | 2815 | 1407.5 | 82.4 | 41.2 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2459 | 2815 | 1407.5 | 42.4 | 21.2 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2460 | 1407 | 1407.0 | 28.4 | 28.4 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | False |
| 2461 | 1407 | 1407.0 | 36.8 | 36.8 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | False |
| 2462 | 1407 | 1407.0 | 29.3 | 29.3 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | False |
| 2463 | 1407 | 1407.0 | 27.9 | 27.9 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2464 | 1407 | 1407.0 | 27.9 | 27.9 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | False |
| 2465 | 4220 | 1406.7 | 106.9 | 35.6 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | False |
| 2466 | 2813 | 1406.5 | 167.4 | 83.7 | Osteoarthritis. | David J Hunter, Sita Bierma-Zeinstra | Lancet | 2019 | 31034380 | False |
| 2467 | 1406 | 1406.0 | 28.8 | 28.8 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | False |
| 2468 | 1406 | 1406.0 | 34.6 | 34.6 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2469 | 1406 | 1406.0 | 31.5 | 31.5 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2470 | 1406 | 1406.0 | 44.3 | 44.3 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2471 | 4218 | 1406.0 | 110.4 | 36.8 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | False |
| 2472 | 2811 | 1405.5 | 98.4 | 49.2 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2473 | 1405 | 1405.0 | 32.6 | 32.6 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2474 | 1405 | 1405.0 | 31.8 | 31.8 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | False |
| 2475 | 1405 | 1405.0 | 25.9 | 25.9 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | False |
| 2476 | 1405 | 1405.0 | 31.3 | 31.3 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | False |
| 2477 | 2810 | 1405.0 | 66.6 | 33.3 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | False |
| 2478 | 1405 | 1405.0 | 33.9 | 33.9 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | False |
| 2479 | 2810 | 1405.0 | 100.5 | 50.2 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2480 | 7016 | 1403.2 | 262.4 | 52.5 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2481 | 1403 | 1403.0 | 43.3 | 43.3 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2482 | 1403 | 1403.0 | 56.7 | 56.7 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | False |
| 2483 | 1402 | 1402.0 | 45.8 | 45.8 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | False |
| 2484 | 4206 | 1402.0 | 116.9 | 39.0 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2485 | 1401 | 1401.0 | 43.0 | 43.0 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | False |
| 2486 | 2802 | 1401.0 | 61.9 | 30.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2487 | 1401 | 1401.0 | 60.5 | 60.5 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | False |
| 2488 | 4202 | 1400.7 | 91.8 | 30.6 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | False |
| 2489 | 1400 | 1400.0 | 35.7 | 35.7 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2490 | 1400 | 1400.0 | 32.5 | 32.5 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | False |
| 2491 | 22382 | 1398.9 | 608.1 | 38.0 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | False |
| 2492 | 2796 | 1398.0 | 57.7 | 28.9 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | False |
| 2493 | 1398 | 1398.0 | 36.4 | 36.4 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | False |
| 2494 | 1397 | 1397.0 | 25.1 | 25.1 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | False |
| 2495 | 1397 | 1397.0 | 28.8 | 28.8 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | False |
| 2496 | 1397 | 1397.0 | 38.3 | 38.3 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | False |
| 2497 | 8379 | 1396.5 | 204.6 | 34.1 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2498 | 1396 | 1396.0 | 39.4 | 39.4 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | False |
| 2499 | 2791 | 1395.5 | 81.6 | 40.8 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P DOLE, H MEINERTZ | J Biol Chem | 1960 | 13817286 | Yes |
| 2500 | 2791 | 1395.5 | 65.6 | 32.8 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | False |
| 2501 | 8370 | 1395.0 | 301.7 | 50.3 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2502 | 2789 | 1394.5 | 69.1 | 34.5 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | False |
| 2503 | 2788 | 1394.0 | 62.4 | 31.2 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2504 | 2788 | 1394.0 | 60.8 | 30.4 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2505 | 2788 | 1394.0 | 72.6 | 36.3 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2506 | 1393 | 1393.0 | 43.5 | 43.5 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | False |
| 2507 | 2784 | 1392.0 | 100.9 | 50.5 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | False |
| 2508 | 1392 | 1392.0 | 30.7 | 30.7 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | False |
| 2509 | 1392 | 1392.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F ROSENBLATT | Psychol Rev | 1958 | 13602029 | Yes |
| 2510 | 2783 | 1391.5 | 61.5 | 30.8 | Immunoassay of endogenous plasma insulin in man. | R S YALOW, S A BERSON | J Clin Invest | 1960 | 13846364 | Yes |
| 2511 | 6956 | 1391.2 | 251.6 | 50.3 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2512 | 2782 | 1391.0 | 94.9 | 47.5 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | False |
| 2513 | 1391 | 1391.0 | 31.1 | 31.1 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | False |
| 2514 | 2782 | 1391.0 | 83.2 | 41.6 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2515 | 4172 | 1390.7 | 126.2 | 42.1 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | False |
| 2516 | 2781 | 1390.5 | 69.0 | 34.5 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | False |
| 2517 | 2780 | 1390.0 | 126.3 | 63.1 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2518 | 1390 | 1390.0 | 34.2 | 34.2 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | False |
| 2519 | 1390 | 1390.0 | 39.8 | 39.8 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | False |
| 2520 | 4169 | 1389.7 | 155.5 | 51.8 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 2521 | 1389 | 1389.0 | 28.5 | 28.5 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2522 | 5554 | 1388.5 | 257.2 | 64.3 | Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do | Nat Genet | 2018 | 29686387 | Yes |
| 2523 | 1388 | 1388.0 | 40.7 | 40.7 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | False |
| 2524 | 1388 | 1388.0 | 37.2 | 37.2 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | False |
| 2525 | 4164 | 1388.0 | 95.6 | 31.9 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2526 | 2776 | 1388.0 | 68.5 | 34.2 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | False |
| 2527 | 8325 | 1387.5 | 251.8 | 42.0 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdóttir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 2528 | 1387 | 1387.0 | 30.9 | 30.9 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | False |
| 2529 | 1387 | 1387.0 | 22.3 | 22.3 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | False |
| 2530 | 1387 | 1387.0 | 41.0 | 41.0 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | False |
| 2531 | 2773 | 1386.5 | 88.5 | 44.2 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2532 | 1386 | 1386.0 | 60.1 | 60.1 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2533 | 1386 | 1386.0 | 25.6 | 25.6 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | False |
| 2534 | 2772 | 1386.0 | 61.9 | 30.9 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | False |
| 2535 | 2772 | 1386.0 | 59.7 | 29.9 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2536 | 2770 | 1385.0 | 71.1 | 35.5 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2537 | 2770 | 1385.0 | 104.1 | 52.0 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2538 | 6925 | 1385.0 | 129.3 | 25.9 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2539 | 1385 | 1385.0 | 54.0 | 54.0 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A de Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 2540 | 2769 | 1384.5 | 111.4 | 55.7 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2541 | 5537 | 1384.2 | 192.1 | 48.0 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2542 | 1384 | 1384.0 | 29.5 | 29.5 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | False |
| 2543 | 1384 | 1384.0 | 20.9 | 20.9 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2544 | 1384 | 1384.0 | 52.7 | 52.7 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2545 | 2767 | 1383.5 | 63.2 | 31.6 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | False |
| 2546 | 2767 | 1383.5 | 98.6 | 49.3 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | False |
| 2547 | 2766 | 1383.0 | 169.6 | 84.8 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2548 | 1383 | 1383.0 | 46.9 | 46.9 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2549 | 1383 | 1383.0 | 38.0 | 38.0 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2550 | 1383 | 1383.0 | 49.2 | 49.2 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | False |
| 2551 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C SCHNEIDER | J Biol Chem | 1948 | 18886166 | Yes |
| 2552 | 2763 | 1381.5 | 70.3 | 35.1 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2553 | 4144 | 1381.3 | 83.2 | 27.7 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | False |
| 2554 | 2762 | 1381.0 | 105.1 | 52.5 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2555 | 1381 | 1381.0 | 24.0 | 24.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2556 | 2761 | 1380.5 | 77.1 | 38.5 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2557 | 1380 | 1380.0 | 26.1 | 26.1 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | False |
| 2558 | 4138 | 1379.3 | 93.3 | 31.1 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | False |
| 2559 | 2758 | 1379.0 | 55.5 | 27.8 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | False |
| 2560 | 6894 | 1378.8 | 185.4 | 37.1 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2561 | 4134 | 1378.0 | 104.9 | 35.0 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2562 | 4134 | 1378.0 | 90.9 | 30.3 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | False |
| 2563 | 5511 | 1377.8 | 286.4 | 71.6 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 2564 | 1377 | 1377.0 | 27.5 | 27.5 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | False |
| 2565 | 1377 | 1377.0 | 34.3 | 34.3 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | False |
| 2566 | 2752 | 1376.0 | 70.2 | 35.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2567 | 1376 | 1376.0 | 24.0 | 24.0 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | False |
| 2568 | 1376 | 1376.0 | 34.2 | 34.2 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | False |
| 2569 | 4126 | 1375.3 | 78.7 | 26.2 | Exosomes: composition, biogenesis and function. | Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | False |
| 2570 | 1375 | 1375.0 | 36.1 | 36.1 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | False |
| 2571 | 5500 | 1375.0 | 118.8 | 29.7 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2572 | 1375 | 1375.0 | 34.9 | 34.9 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | False |
| 2573 | 1375 | 1375.0 | 28.4 | 28.4 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | False |
| 2574 | 1374 | 1374.0 | 43.1 | 43.1 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | False |
| 2575 | 1374 | 1374.0 | 38.2 | 38.2 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2576 | 1374 | 1374.0 | 40.4 | 40.4 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | False |
| 2577 | 1374 | 1374.0 | 29.4 | 29.4 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | False |
| 2578 | 2746 | 1373.0 | 96.3 | 48.1 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2579 | 1372 | 1372.0 | 27.6 | 27.6 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | False |
| 2580 | 5488 | 1372.0 | 146.0 | 36.5 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2581 | 5487 | 1371.8 | 139.8 | 35.0 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2582 | 2743 | 1371.5 | 53.4 | 26.7 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | False |
| 2583 | 2742 | 1371.0 | 60.7 | 30.4 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2584 | 1371 | 1371.0 | 49.0 | 49.0 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2585 | 1371 | 1371.0 | 32.2 | 32.2 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | False |
| 2586 | 2741 | 1370.5 | 54.9 | 27.4 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2587 | 8221 | 1370.2 | 217.6 | 36.3 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2588 | 1370 | 1370.0 | 31.8 | 31.8 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | False |
| 2589 | 1370 | 1370.0 | 24.8 | 24.8 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | False |
| 2590 | 4109 | 1369.7 | 119.7 | 39.9 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2591 | 1369 | 1369.0 | 72.0 | 72.0 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | False |
| 2592 | 2737 | 1368.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B CHANCE, G R WILLIAMS | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2593 | 1368 | 1368.0 | 43.6 | 43.6 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | False |
| 2594 | 1368 | 1368.0 | 30.8 | 30.8 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | False |
| 2595 | 2736 | 1368.0 | 54.3 | 27.1 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | False |
| 2596 | 1368 | 1368.0 | 46.2 | 46.2 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | False |
| 2597 | 2735 | 1367.5 | 70.4 | 35.2 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | False |
| 2598 | 1367 | 1367.0 | 48.0 | 48.0 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2599 | 1367 | 1367.0 | 41.5 | 41.5 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2600 | 2733 | 1366.5 | 53.8 | 26.9 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2601 | 5466 | 1366.5 | 125.8 | 31.4 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2602 | 2732 | 1366.0 | 56.0 | 28.0 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2603 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O SMITHIES | Biochem J | 1959 | 13638269 | Yes |
| 2604 | 1366 | 1366.0 | 39.1 | 39.1 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2605 | 2731 | 1365.5 | 65.2 | 32.6 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2606 | 2731 | 1365.5 | 72.1 | 36.0 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 2607 | 9557 | 1365.3 | 3598.9 | 514.1 | Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Mathieu Laversanne, Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Isabelle Soerjomataram, Ahmedin Jemal | CA Cancer J Clin | 2024 | 38572751 | Yes |
| 2608 | 8191 | 1365.2 | 203.0 | 33.8 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2609 | 1365 | 1365.0 | 32.7 | 32.7 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2610 | 1365 | 1365.0 | 11.6 | 11.6 | Immunological function of the thymus. | J F MILLER | Lancet | 1961 | 14474038 | Yes |
| 2611 | 9554 | 1364.9 | 279.8 | 40.0 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2612 | 1364 | 1364.0 | 46.1 | 46.1 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | False |
| 2613 | 1364 | 1364.0 | 34.4 | 34.4 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | False |
| 2614 | 1364 | 1364.0 | 23.6 | 23.6 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | False |
| 2615 | 1363 | 1363.0 | 46.7 | 46.7 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | False |
| 2616 | 1363 | 1363.0 | 32.3 | 32.3 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | False |
| 2617 | 1363 | 1363.0 | 52.8 | 52.8 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | False |
| 2618 | 2726 | 1363.0 | 107.6 | 53.8 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 2619 | 1362 | 1362.0 | 27.0 | 27.0 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | False |
| 2620 | 2724 | 1362.0 | 67.0 | 33.5 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | False |
| 2621 | 2722 | 1361.0 | 0.0 | 0.0 | Construct validity in psychological tests. | L J CRONBACH, P E MEEHL | Psychol Bull | 1955 | 13245896 | Yes |
| 2622 | 2721 | 1360.5 | 82.4 | 41.2 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | False |
| 2623 | 1360 | 1360.0 | 31.2 | 31.2 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2624 | 1360 | 1360.0 | 22.8 | 22.8 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | False |
| 2625 | 1360 | 1360.0 | 36.6 | 36.6 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | False |
| 2626 | 2719 | 1359.5 | 230.2 | 115.1 | Gut microbiota in human metabolic health and disease. | Yong Fan, Oluf Pedersen | Nat Rev Microbiol | 2021 | 32887946 | False |
| 2627 | 4078 | 1359.3 | 145.1 | 48.4 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2628 | 1359 | 1359.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B CLOWARD | J Neurosurg | 1958 | 13599052 | Yes |
| 2629 | 1359 | 1359.0 | 30.9 | 30.9 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | False |
| 2630 | 1359 | 1359.0 | 35.5 | 35.5 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | False |
| 2631 | 1359 | 1359.0 | 34.7 | 34.7 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | False |
| 2632 | 1358 | 1358.0 | 33.7 | 33.7 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | False |
| 2633 | 1358 | 1358.0 | 28.2 | 28.2 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2634 | 1358 | 1358.0 | 0.0 | 0.0 | On the psychophysical law. | S S STEVENS | Psychol Rev | 1957 | 13441853 | Yes |
| 2635 | 1358 | 1358.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B CAULFIELD | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2636 | 4074 | 1358.0 | 117.5 | 39.2 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | False |
| 2637 | 1357 | 1357.0 | 41.9 | 41.9 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | False |
| 2638 | 1357 | 1357.0 | 32.1 | 32.1 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2639 | 1357 | 1357.0 | 10.8 | 10.8 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2640 | 1357 | 1357.0 | 41.7 | 41.7 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2641 | 1357 | 1357.0 | 47.4 | 47.4 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | False |
| 2642 | 1357 | 1357.0 | 36.4 | 36.4 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | False |
| 2643 | 1356 | 1356.0 | 41.1 | 41.1 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | False |
| 2644 | 1356 | 1356.0 | 39.0 | 39.0 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | False |
| 2645 | 1356 | 1356.0 | 42.8 | 42.8 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | False |
| 2646 | 2711 | 1355.5 | 163.0 | 81.5 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2647 | 2711 | 1355.5 | 322.7 | 161.3 | Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. | Luke A McGuinness, Julian P T Higgins | Res Synth Methods | 2021 | 32336025 | Yes |
| 2648 | 2709 | 1354.5 | 73.7 | 36.9 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2649 | 1354 | 1354.0 | 63.6 | 63.6 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | False |
| 2650 | 1354 | 1354.0 | 30.8 | 30.8 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | False |
| 2651 | 5413 | 1353.2 | 124.2 | 31.1 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2652 | 1353 | 1353.0 | 58.2 | 58.2 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2653 | 1353 | 1353.0 | 42.0 | 42.0 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | False |
| 2654 | 2706 | 1353.0 | 62.0 | 31.0 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | False |
| 2655 | 1353 | 1353.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M REITAN | J Consult Psychol | 1955 | 13263471 | Yes |
| 2656 | 1352 | 1352.0 | 28.5 | 28.5 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2657 | 1352 | 1352.0 | 44.7 | 44.7 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | False |
| 2658 | 1352 | 1352.0 | 40.0 | 40.0 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | False |
| 2659 | 4055 | 1351.7 | 53.3 | 17.8 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D SABATINI, K BENSCH, R J BARRNETT | J Cell Biol | 1963 | 13975866 | Yes |
| 2660 | 2703 | 1351.5 | 98.4 | 49.2 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 2661 | 1351 | 1351.0 | 25.8 | 25.8 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | False |
| 2662 | 1351 | 1351.0 | 28.6 | 28.6 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | False |
| 2663 | 5404 | 1351.0 | 105.4 | 26.4 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2664 | 1351 | 1351.0 | 35.2 | 35.2 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | False |
| 2665 | 1351 | 1351.0 | 27.2 | 27.2 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | False |
| 2666 | 2701 | 1350.5 | 61.2 | 30.6 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | False |
| 2667 | 1350 | 1350.0 | 48.2 | 48.2 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | False |
| 2668 | 1350 | 1350.0 | 34.1 | 34.1 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | False |
| 2669 | 2700 | 1350.0 | 47.0 | 23.5 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | False |
| 2670 | 1350 | 1350.0 | 30.2 | 30.2 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2671 | 2699 | 1349.5 | 56.8 | 28.4 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | False |
| 2672 | 13493 | 1349.3 | 502.5 | 50.2 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 2673 | 8096 | 1349.3 | 283.3 | 47.2 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 2674 | 1349 | 1349.0 | 29.6 | 29.6 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2675 | 1348 | 1348.0 | 35.3 | 35.3 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | False |
| 2676 | 2696 | 1348.0 | 59.1 | 29.6 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2677 | 1348 | 1348.0 | 32.8 | 32.8 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | False |
| 2678 | 1348 | 1348.0 | 35.0 | 35.0 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | False |
| 2679 | 5389 | 1347.2 | 116.3 | 29.1 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2680 | 2694 | 1347.0 | 119.5 | 59.8 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2681 | 1347 | 1347.0 | 43.0 | 43.0 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | False |
| 2682 | 1347 | 1347.0 | 43.2 | 43.2 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 2683 | 1347 | 1347.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J WADDELL | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2684 | 1346 | 1346.0 | 37.9 | 37.9 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | False |
| 2685 | 1346 | 1346.0 | 23.0 | 23.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2686 | 4037 | 1345.7 | 91.1 | 30.4 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | False |
| 2687 | 2691 | 1345.5 | 62.0 | 31.0 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2688 | 1345 | 1345.0 | 31.6 | 31.6 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | False |
| 2689 | 2688 | 1344.0 | 66.8 | 33.4 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | False |
| 2690 | 2687 | 1343.5 | 65.9 | 33.0 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | False |
| 2691 | 2686 | 1343.0 | 88.1 | 44.0 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2692 | 1343 | 1343.0 | 14.5 | 14.5 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | False |
| 2693 | 2686 | 1343.0 | 68.4 | 34.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | False |
| 2694 | 1343 | 1343.0 | 37.2 | 37.2 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | False |
| 2695 | 1343 | 1343.0 | 32.6 | 32.6 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2696 | 1342 | 1342.0 | 35.5 | 35.5 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | False |
| 2697 | 1342 | 1342.0 | 23.2 | 23.2 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | False |
| 2698 | 1342 | 1342.0 | 63.1 | 63.1 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 2699 | 2684 | 1342.0 | 84.8 | 42.4 | CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. | Jing Huang, Alexander D MacKerell | J Comput Chem | 2013 | 23832629 | Yes |
| 2700 | 2682 | 1341.0 | 55.7 | 27.9 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | False |
| 2701 | 2681 | 1340.5 | 39.1 | 19.6 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2702 | 2681 | 1340.5 | 57.4 | 28.7 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2703 | 1340 | 1340.0 | 33.4 | 33.4 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | False |
| 2704 | 1340 | 1340.0 | 35.6 | 35.6 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2705 | 8040 | 1340.0 | 224.8 | 37.5 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | False |
| 2706 | 1340 | 1340.0 | 51.2 | 51.2 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | False |
| 2707 | 2679 | 1339.5 | 112.0 | 56.0 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 2708 | 1339 | 1339.0 | 17.2 | 17.2 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | False |
| 2709 | 1339 | 1339.0 | 29.6 | 29.6 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2710 | 4017 | 1339.0 | 127.5 | 42.5 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2711 | 2677 | 1338.5 | 68.6 | 34.3 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2712 | 1338 | 1338.0 | 46.7 | 46.7 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2713 | 2676 | 1338.0 | 68.6 | 34.3 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | False |
| 2714 | 1337 | 1337.0 | 35.0 | 35.0 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | False |
| 2715 | 1337 | 1337.0 | 25.2 | 25.2 | A modified procedure for lead staining of thin sections. | G MILLONIG | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2716 | 1337 | 1337.0 | 39.8 | 39.8 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | False |
| 2717 | 1336 | 1336.0 | 48.0 | 48.0 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2718 | 1336 | 1336.0 | 22.9 | 22.9 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | False |
| 2719 | 2671 | 1335.5 | 133.7 | 66.8 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2720 | 2670 | 1335.0 | 79.6 | 39.8 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2721 | 1335 | 1335.0 | 44.0 | 44.0 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | False |
| 2722 | 1335 | 1335.0 | 55.2 | 55.2 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2723 | 1335 | 1335.0 | 24.3 | 24.3 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | False |
| 2724 | 1335 | 1335.0 | 28.2 | 28.2 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 2725 | 2670 | 1335.0 | 114.0 | 57.0 | AMPK: guardian of metabolism and mitochondrial homeostasis. | Sébastien Herzig, Reuben J Shaw | Nat Rev Mol Cell Biol | 2018 | 28974774 | False |
| 2726 | 2668 | 1334.0 | 49.8 | 24.9 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 2727 | 1333 | 1333.0 | 63.3 | 63.3 | Cellular resistance to infection. | G B MACKANESS | J Exp Med | 1962 | 14467923 | Yes |
| 2728 | 2664 | 1332.0 | 200.4 | 100.2 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2729 | 1332 | 1332.0 | 24.6 | 24.6 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | False |
| 2730 | 1332 | 1332.0 | 50.7 | 50.7 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | False |
| 2731 | 3995 | 1331.7 | 98.8 | 32.9 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2732 | 2663 | 1331.5 | 44.8 | 22.4 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | False |
| 2733 | 1331 | 1331.0 | 45.1 | 45.1 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | False |
| 2734 | 2662 | 1331.0 | 53.3 | 26.6 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 2735 | 5321 | 1330.2 | 119.1 | 29.8 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | False |
| 2736 | 5320 | 1330.0 | 130.4 | 32.6 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 2737 | 1330 | 1330.0 | 80.2 | 80.2 | Head and Neck Cancer. | Laura Q M Chow | N Engl J Med | 2020 | 31893516 | False |
| 2738 | 2659 | 1329.5 | 100.4 | 50.2 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2739 | 2658 | 1329.0 | 49.3 | 24.6 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2740 | 1329 | 1329.0 | 65.5 | 65.5 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2741 | 1329 | 1329.0 | 29.8 | 29.8 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | False |
| 2742 | 3987 | 1329.0 | 82.5 | 27.5 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2743 | 3987 | 1329.0 | 83.7 | 27.9 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 2744 | 2658 | 1329.0 | 51.9 | 25.9 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | False |
| 2745 | 5312 | 1328.0 | 167.7 | 41.9 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2746 | 1328 | 1328.0 | 35.1 | 35.1 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | False |
| 2747 | 1328 | 1328.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J BERKSON | Biometrics | 1946 | 21001024 | Yes |
| 2748 | 2655 | 1327.5 | 72.5 | 36.2 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | False |
| 2749 | 5307 | 1326.8 | 122.8 | 30.7 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2750 | 2652 | 1326.0 | 60.0 | 30.0 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | False |
| 2751 | 1326 | 1326.0 | 33.4 | 33.4 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | False |
| 2752 | 2651 | 1325.5 | 63.6 | 31.8 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | False |
| 2753 | 5300 | 1325.0 | 295.9 | 74.0 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2754 | 1325 | 1325.0 | 24.7 | 24.7 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2755 | 1325 | 1325.0 | 32.5 | 32.5 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2756 | 1325 | 1325.0 | 29.8 | 29.8 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | False |
| 2757 | 1325 | 1325.0 | 62.9 | 62.9 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 2758 | 5299 | 1324.8 | 258.6 | 64.7 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 2759 | 1324 | 1324.0 | 44.7 | 44.7 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 2760 | 2647 | 1323.5 | 77.8 | 38.9 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | False |
| 2761 | 2647 | 1323.5 | 58.5 | 29.2 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | False |
| 2762 | 3970 | 1323.3 | 96.5 | 32.2 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | False |
| 2763 | 1323 | 1323.0 | 35.5 | 35.5 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | False |
| 2764 | 1323 | 1323.0 | 34.5 | 34.5 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | False |
| 2765 | 2646 | 1323.0 | 62.1 | 31.1 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2766 | 1323 | 1323.0 | 32.0 | 32.0 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2767 | 1323 | 1323.0 | 48.7 | 48.7 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | False |
| 2768 | 2646 | 1323.0 | 98.7 | 49.4 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | False |
| 2769 | 1323 | 1323.0 | 64.1 | 64.1 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | False |
| 2770 | 2645 | 1322.5 | 75.5 | 37.8 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M van der Bliek | Science | 2012 | 22936770 | False |
| 2771 | 1322 | 1322.0 | 35.1 | 35.1 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 2772 | 2642 | 1321.0 | 71.1 | 35.5 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | False |
| 2773 | 1321 | 1321.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2774 | 1321 | 1321.0 | 39.5 | 39.5 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | False |
| 2775 | 3962 | 1320.7 | 122.6 | 40.9 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2776 | 1320 | 1320.0 | 22.6 | 22.6 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | False |
| 2777 | 1320 | 1320.0 | 27.0 | 27.0 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | False |
| 2778 | 1320 | 1320.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W TUKEY | Biometrics | 1949 | 18151955 | Yes |
| 2779 | 1320 | 1320.0 | 27.2 | 27.2 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | False |
| 2780 | 2639 | 1319.5 | 84.6 | 42.3 | MissForest--non-parametric missing value imputation for mixed-type data. | Daniel J Stekhoven, Peter Bühlmann | Bioinformatics | 2012 | 22039212 | Yes |
| 2781 | 1319 | 1319.0 | 45.5 | 45.5 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2782 | 2638 | 1319.0 | 70.5 | 35.2 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 2783 | 2638 | 1319.0 | 52.2 | 26.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | False |
| 2784 | 2637 | 1318.5 | 64.0 | 32.0 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | False |
| 2785 | 1318 | 1318.0 | 48.0 | 48.0 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | False |
| 2786 | 6589 | 1317.8 | 161.9 | 32.4 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 2787 | 1317 | 1317.0 | 50.9 | 50.9 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2788 | 2634 | 1317.0 | 64.9 | 32.5 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | False |
| 2789 | 2632 | 1316.0 | 40.5 | 20.2 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 2790 | 1316 | 1316.0 | 34.2 | 34.2 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2791 | 1316 | 1316.0 | 37.1 | 37.1 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2792 | 5260 | 1315.0 | 158.0 | 39.5 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | False |
| 2793 | 3942 | 1314.0 | 93.2 | 31.1 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2794 | 1314 | 1314.0 | 31.1 | 31.1 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | False |
| 2795 | 1314 | 1314.0 | 45.7 | 45.7 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | False |
| 2796 | 1314 | 1314.0 | 22.0 | 22.0 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | False |
| 2797 | 2628 | 1314.0 | 45.9 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2798 | 2627 | 1313.5 | 90.2 | 45.1 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2799 | 2627 | 1313.5 | 64.9 | 32.5 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | False |
| 2800 | 10506 | 1313.2 | 257.9 | 32.2 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2801 | 1313 | 1313.0 | 37.2 | 37.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | False |
| 2802 | 3939 | 1313.0 | 192.8 | 64.3 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2803 | 1313 | 1313.0 | 35.7 | 35.7 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 2804 | 1313 | 1313.0 | 27.5 | 27.5 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2805 | 1313 | 1313.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A BERG | J Gen Psychol | 1948 | 18889466 | Yes |
| 2806 | 2626 | 1313.0 | 104.9 | 52.5 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | False |
| 2807 | 3938 | 1312.7 | 119.5 | 39.8 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2808 | 1312 | 1312.0 | 54.5 | 54.5 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2809 | 1312 | 1312.0 | 33.8 | 33.8 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | False |
| 2810 | 1312 | 1312.0 | 36.0 | 36.0 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | False |
| 2811 | 1312 | 1312.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F SCHOLANDER | J Biol Chem | 1947 | 20281644 | Yes |
| 2812 | 11807 | 1311.9 | 289.0 | 32.1 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2813 | 2622 | 1311.0 | 49.6 | 24.8 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 2814 | 2622 | 1311.0 | 50.1 | 25.1 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | False |
| 2815 | 5244 | 1311.0 | 132.6 | 33.1 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2816 | 2621 | 1310.5 | 43.4 | 21.7 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 2817 | 2621 | 1310.5 | 78.3 | 39.1 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | False |
| 2818 | 1310 | 1310.0 | 56.3 | 56.3 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2819 | 2620 | 1310.0 | 57.0 | 28.5 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | False |
| 2820 | 2619 | 1309.5 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A EDMONDSON, P E STEINER | Cancer | 1954 | 13160935 | Yes |
| 2821 | 2619 | 1309.5 | 54.9 | 27.4 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | False |
| 2822 | 1309 | 1309.0 | 32.1 | 32.1 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | False |
| 2823 | 1309 | 1309.0 | 39.4 | 39.4 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | False |
| 2824 | 1309 | 1309.0 | 27.5 | 27.5 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | False |
| 2825 | 1309 | 1309.0 | 32.0 | 32.0 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2826 | 2617 | 1308.5 | 59.3 | 29.6 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2827 | 1308 | 1308.0 | 34.3 | 34.3 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | False |
| 2828 | 1308 | 1308.0 | 35.1 | 35.1 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | False |
| 2829 | 2616 | 1308.0 | 67.1 | 33.5 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | False |
| 2830 | 1308 | 1308.0 | 34.6 | 34.6 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | False |
| 2831 | 2615 | 1307.5 | 97.2 | 48.6 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | False |
| 2832 | 1307 | 1307.0 | 28.6 | 28.6 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | False |
| 2833 | 1307 | 1307.0 | 42.9 | 42.9 | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. | Tristan Ian Croll | Acta Crystallogr D Struct Biol | 2018 | 29872003 | Yes |
| 2834 | 2613 | 1306.5 | 74.1 | 37.0 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | False |
| 2835 | 2612 | 1306.0 | 55.2 | 27.6 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | False |
| 2836 | 1306 | 1306.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S FARR | J Infect Dis | 1958 | 13611294 | Yes |
| 2837 | 2611 | 1305.5 | 61.4 | 30.7 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 2838 | 2610 | 1305.0 | 82.8 | 41.4 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | False |
| 2839 | 1305 | 1305.0 | 30.8 | 30.8 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | False |
| 2840 | 2610 | 1305.0 | 46.7 | 23.4 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | False |
| 2841 | 1304 | 1304.0 | 61.4 | 61.4 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 2842 | 1304 | 1304.0 | 23.2 | 23.2 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | False |
| 2843 | 1304 | 1304.0 | 29.7 | 29.7 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | False |
| 2844 | 5213 | 1303.2 | 143.6 | 35.9 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 2845 | 2606 | 1303.0 | 24.1 | 12.1 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 2846 | 1303 | 1303.0 | 28.8 | 28.8 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 2847 | 6513 | 1302.6 | 334.6 | 66.9 | Standards for reporting qualitative research: a synthesis of recommendations. | Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook | Acad Med | 2014 | 24979285 | Yes |
| 2848 | 3907 | 1302.3 | 90.9 | 30.3 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 2849 | 3906 | 1302.0 | 172.7 | 57.6 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2850 | 1302 | 1302.0 | 29.9 | 29.9 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | False |
| 2851 | 2603 | 1301.5 | 118.9 | 59.5 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | False |
| 2852 | 1301 | 1301.0 | 42.1 | 42.1 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | False |
| 2853 | 2602 | 1301.0 | 94.4 | 47.2 | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. | Christoph Hafemeister, Rahul Satija | Genome Biol | 2019 | 31870423 | Yes |
| 2854 | 2601 | 1300.5 | 86.7 | 43.4 | Severe sepsis and septic shock. | Derek C Angus, Tom van der Poll | N Engl J Med | 2013 | 23984731 | False |
| 2855 | 3901 | 1300.3 | 114.1 | 38.0 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | False |
| 2856 | 2600 | 1300.0 | 83.5 | 41.8 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | False |
| 2857 | 1299 | 1299.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J BATEMAN | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2858 | 1299 | 1299.0 | 35.4 | 35.4 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | False |
| 2859 | 1299 | 1299.0 | 58.9 | 58.9 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 2860 | 3896 | 1298.7 | 96.9 | 32.3 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 2861 | 1298 | 1298.0 | 26.0 | 26.0 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | False |
| 2862 | 5191 | 1297.8 | 134.9 | 33.7 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 2863 | 2595 | 1297.5 | 63.0 | 31.5 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | False |
| 2864 | 1297 | 1297.0 | 30.9 | 30.9 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | False |
| 2865 | 3890 | 1296.7 | 104.8 | 34.9 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2866 | 2593 | 1296.5 | 59.2 | 29.6 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | False |
| 2867 | 1296 | 1296.0 | 43.0 | 43.0 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | False |
| 2868 | 2592 | 1296.0 | 51.3 | 25.6 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | False |
| 2869 | 2592 | 1296.0 | 82.1 | 41.0 | Liquid phase condensation in cell physiology and disease. | Yongdae Shin, Clifford P Brangwynne | Science | 2017 | 28935776 | False |
| 2870 | 2591 | 1295.5 | 49.8 | 24.9 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 2871 | 1295 | 1295.0 | 51.7 | 51.7 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | Yes |
| 2872 | 3883 | 1294.3 | 120.4 | 40.1 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | False |
| 2873 | 1294 | 1294.0 | 51.6 | 51.6 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2874 | 1294 | 1294.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C BRUTON | Pediatrics | 1952 | 14929630 | Yes |
| 2875 | 5175 | 1293.8 | 106.8 | 26.7 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | False |
| 2876 | 2587 | 1293.5 | 77.0 | 38.5 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 2877 | 2587 | 1293.5 | 67.4 | 33.7 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 2878 | 1293 | 1293.0 | 28.9 | 28.9 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | False |
| 2879 | 1293 | 1293.0 | 42.6 | 42.6 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 2880 | 2586 | 1293.0 | 52.7 | 26.4 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | False |
| 2881 | 3879 | 1293.0 | 104.0 | 34.7 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | False |
| 2882 | 5172 | 1293.0 | 228.2 | 57.0 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Göker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 2883 | 3877 | 1292.3 | 161.0 | 53.7 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 2884 | 1292 | 1292.0 | 42.2 | 42.2 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 2885 | 2584 | 1292.0 | 54.1 | 27.1 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | False |
| 2886 | 2584 | 1292.0 | 72.1 | 36.0 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 2887 | 1292 | 1292.0 | 25.1 | 25.1 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2888 | 1292 | 1292.0 | 61.8 | 61.8 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 2889 | 2583 | 1291.5 | 105.3 | 52.6 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2890 | 1291 | 1291.0 | 84.2 | 84.2 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 2891 | 1291 | 1291.0 | 32.3 | 32.3 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | False |
| 2892 | 2582 | 1291.0 | 56.5 | 28.2 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | False |
| 2893 | 5163 | 1290.8 | 142.0 | 35.5 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 2894 | 3872 | 1290.7 | 90.6 | 30.2 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | False |
| 2895 | 2581 | 1290.5 | 65.5 | 32.8 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | False |
| 2896 | 2581 | 1290.5 | 72.3 | 36.1 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | False |
| 2897 | 2581 | 1290.5 | 83.4 | 41.7 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschöpe | J Am Coll Cardiol | 2013 | 23684677 | False |
| 2898 | 1290 | 1290.0 | 32.4 | 32.4 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 2899 | 2579 | 1289.5 | 64.9 | 32.5 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2900 | 1289 | 1289.0 | 46.7 | 46.7 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 2901 | 1289 | 1289.0 | 32.1 | 32.1 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 2902 | 1289 | 1289.0 | 34.2 | 34.2 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2903 | 2577 | 1288.5 | 87.2 | 43.6 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | False |
| 2904 | 3865 | 1288.3 | 121.0 | 40.3 | Mendelian randomization analysis with multiple genetic variants using summarized data. | Stephen Burgess, Adam Butterworth, Simon G Thompson | Genet Epidemiol | 2013 | 24114802 | Yes |
| 2905 | 1288 | 1288.0 | 34.4 | 34.4 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | False |
| 2906 | 1288 | 1288.0 | 36.8 | 36.8 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 2907 | 1288 | 1288.0 | 26.6 | 26.6 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | False |
| 2908 | 2575 | 1287.5 | 76.0 | 38.0 | Opportunities and challenges for a sustainable energy future. | Steven Chu, Arun Majumdar | Nature | 2012 | 22895334 | False |
| 2909 | 2574 | 1287.0 | 89.9 | 45.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | False |
| 2910 | 1287 | 1287.0 | 30.1 | 30.1 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | False |
| 2911 | 1287 | 1287.0 | 32.2 | 32.2 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | False |
| 2912 | 2574 | 1287.0 | 67.1 | 33.5 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | False |
| 2913 | 2573 | 1286.5 | 60.8 | 30.4 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 2914 | 2573 | 1286.5 | 44.4 | 22.2 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | False |
| 2915 | 1286 | 1286.0 | 45.5 | 45.5 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2916 | 1286 | 1286.0 | 39.6 | 39.6 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | False |
| 2917 | 1286 | 1286.0 | 31.0 | 31.0 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2918 | 1286 | 1286.0 | 29.5 | 29.5 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | False |
| 2919 | 2571 | 1285.5 | 70.4 | 35.2 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2920 | 2571 | 1285.5 | 44.7 | 22.4 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | False |
| 2921 | 1285 | 1285.0 | 38.8 | 38.8 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | False |
| 2922 | 1285 | 1285.0 | 29.9 | 29.9 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | False |
| 2923 | 1285 | 1285.0 | 30.7 | 30.7 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | False |
| 2924 | 1285 | 1285.0 | 26.0 | 26.0 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | False |
| 2925 | 2569 | 1284.5 | 66.9 | 33.5 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 2926 | 1284 | 1284.0 | 61.2 | 61.2 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | False |
| 2927 | 1284 | 1284.0 | 30.8 | 30.8 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 2928 | 1284 | 1284.0 | 33.5 | 33.5 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | False |
| 2929 | 1284 | 1284.0 | 43.4 | 43.4 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | False |
| 2930 | 2568 | 1284.0 | 47.8 | 23.9 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 2931 | 1284 | 1284.0 | 30.5 | 30.5 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 2932 | 1284 | 1284.0 | 26.8 | 26.8 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | False |
| 2933 | 1284 | 1284.0 | 37.9 | 37.9 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | False |
| 2934 | 2567 | 1283.5 | 92.8 | 46.4 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Théry | Cell | 2016 | 26967288 | False |
| 2935 | 2567 | 1283.5 | 136.3 | 68.2 | Depression. | Gin S Malhi, J John Mann | Lancet | 2018 | 30396512 | False |
| 2936 | 3850 | 1283.3 | 88.8 | 29.6 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | False |
| 2937 | 1283 | 1283.0 | 45.9 | 45.9 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | False |
| 2938 | 3848 | 1282.7 | 90.1 | 30.0 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 2939 | 1282 | 1282.0 | 30.3 | 30.3 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | False |
| 2940 | 1281 | 1281.0 | 66.3 | 66.3 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2941 | 1281 | 1281.0 | 27.3 | 27.3 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | False |
| 2942 | 1281 | 1281.0 | 52.8 | 52.8 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 2943 | 2561 | 1280.5 | 67.3 | 33.6 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | False |
| 2944 | 2559 | 1279.5 | 56.3 | 28.1 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P van den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 2945 | 2559 | 1279.5 | 68.6 | 34.3 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 2946 | 7674 | 1279.0 | 219.3 | 36.6 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 2947 | 2558 | 1279.0 | 48.3 | 24.1 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | False |
| 2948 | 1279 | 1279.0 | 64.7 | 64.7 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. | Nicholas A Meanwell | J Med Chem | 2018 | 29400967 | False |
| 2949 | 1278 | 1278.0 | 25.4 | 25.4 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | False |
| 2950 | 1278 | 1278.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M KALCKAR | J Biol Chem | 1947 | 20285041 | Yes |
| 2951 | 6389 | 1277.8 | 200.2 | 40.0 | CD-HIT: accelerated for clustering the next-generation sequencing data. | Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li | Bioinformatics | 2012 | 23060610 | Yes |
| 2952 | 3833 | 1277.7 | 93.7 | 31.2 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | False |
| 2953 | 2555 | 1277.5 | 68.8 | 34.4 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 2954 | 2555 | 1277.5 | 76.0 | 38.0 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | False |
| 2955 | 2554 | 1277.0 | 77.9 | 39.0 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 2956 | 2554 | 1277.0 | 48.9 | 24.4 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 2957 | 1277 | 1277.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L MILLER | Science | 1953 | 13056598 | Yes |
| 2958 | 1277 | 1277.0 | 24.3 | 24.3 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | False |
| 2959 | 1277 | 1277.0 | 43.2 | 43.2 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamás Rőszer | Mediators Inflamm | 2015 | 26089604 | False |
| 2960 | 3830 | 1276.7 | 250.7 | 83.6 | Correlation Coefficients: Appropriate Use and Interpretation. | Patrick Schober, Christa Boer, Lothar A Schwarte | Anesth Analg | 2018 | 29481436 | False |
| 2961 | 2553 | 1276.5 | 49.0 | 24.5 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 2962 | 1276 | 1276.0 | 31.6 | 31.6 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 2963 | 1276 | 1276.0 | 32.5 | 32.5 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | False |
| 2964 | 1276 | 1276.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B VERNEY | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 2965 | 1276 | 1276.0 | 44.2 | 44.2 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 2966 | 2551 | 1275.5 | 58.0 | 29.0 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 2967 | 6377 | 1275.4 | 309.9 | 62.0 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 2968 | 1275 | 1275.0 | 14.2 | 14.2 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 2969 | 1275 | 1275.0 | 28.5 | 28.5 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | False |
| 2970 | 2549 | 1274.5 | 19.9 | 9.9 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J TODARO, H GREEN | J Cell Biol | 1963 | 13985244 | Yes |
| 2971 | 1274 | 1274.0 | 43.5 | 43.5 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 2972 | 1274 | 1274.0 | 46.5 | 46.5 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | False |
| 2973 | 5093 | 1273.2 | 144.1 | 36.0 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 2974 | 1273 | 1273.0 | 58.4 | 58.4 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 2975 | 6365 | 1273.0 | 177.1 | 35.4 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 2976 | 1273 | 1273.0 | 35.9 | 35.9 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | False |
| 2977 | 2546 | 1273.0 | 135.5 | 67.8 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R GUILLARD, J H RYTHER | Can J Microbiol | 1962 | 13902807 | Yes |
| 2978 | 2545 | 1272.5 | 50.6 | 25.3 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 2979 | 1272 | 1272.0 | 29.2 | 29.2 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | False |
| 2980 | 1272 | 1272.0 | 25.8 | 25.8 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | False |
| 2981 | 1272 | 1272.0 | 29.4 | 29.4 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | False |
| 2982 | 1272 | 1272.0 | 34.3 | 34.3 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | False |
| 2983 | 3814 | 1271.3 | 112.9 | 37.6 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | False |
| 2984 | 1271 | 1271.0 | 38.5 | 38.5 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | False |
| 2985 | 7625 | 1270.8 | 226.5 | 37.8 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 2986 | 1270 | 1270.0 | 33.6 | 33.6 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 2987 | 3810 | 1270.0 | 129.4 | 43.1 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 2988 | 1270 | 1270.0 | 24.9 | 24.9 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | False |
| 2989 | 2539 | 1269.5 | 77.7 | 38.9 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | False |
| 2990 | 1269 | 1269.0 | 30.2 | 30.2 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | False |
| 2991 | 1269 | 1269.0 | 42.2 | 42.2 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | False |
| 2992 | 7613 | 1268.8 | 273.0 | 45.5 | Second-generation PLINK: rising to the challenge of larger and richer datasets. | Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee | Gigascience | 2015 | 25722852 | Yes |
| 2993 | 2537 | 1268.5 | 62.1 | 31.1 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | False |
| 2994 | 1268 | 1268.0 | 70.4 | 70.4 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A ROSE | Bull World Health Organ | 1962 | 13974778 | Yes |
| 2995 | 1268 | 1268.0 | 32.1 | 32.1 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 2996 | 2534 | 1267.0 | 56.9 | 28.4 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 2997 | 1267 | 1267.0 | 33.9 | 33.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | False |
| 2998 | 1267 | 1267.0 | 17.0 | 17.0 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 2999 | 1267 | 1267.0 | 37.7 | 37.7 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3000 | 1267 | 1267.0 | 27.7 | 27.7 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | False |
| 3001 | 1267 | 1267.0 | 33.2 | 33.2 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3002 | 1267 | 1267.0 | 24.6 | 24.6 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | False |
| 3003 | 1266 | 1266.0 | 38.1 | 38.1 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | False |
| 3004 | 2532 | 1266.0 | 56.3 | 28.1 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | False |
| 3005 | 3797 | 1265.7 | 95.6 | 31.9 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | False |
| 3006 | 1265 | 1265.0 | 36.0 | 36.0 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | False |
| 3007 | 2530 | 1265.0 | 65.0 | 32.5 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | False |
| 3008 | 2530 | 1265.0 | 64.8 | 32.4 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 3009 | 2528 | 1264.0 | 67.0 | 33.5 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 3010 | 1264 | 1264.0 | 36.6 | 36.6 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | False |
| 3011 | 1264 | 1264.0 | 43.5 | 43.5 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | False |
| 3012 | 1263 | 1263.0 | 20.8 | 20.8 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 3013 | 2526 | 1263.0 | 61.1 | 30.6 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | False |
| 3014 | 1263 | 1263.0 | 42.3 | 42.3 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | False |
| 3015 | 13892 | 1262.9 | 383.3 | 34.8 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 3016 | 2524 | 1262.0 | 72.8 | 36.4 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | False |
| 3017 | 1262 | 1262.0 | 34.5 | 34.5 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | False |
| 3018 | 2524 | 1262.0 | 97.1 | 48.5 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3019 | 2524 | 1262.0 | 93.1 | 46.5 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 3020 | 2524 | 1262.0 | 81.3 | 40.6 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3021 | 1262 | 1262.0 | 26.5 | 26.5 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | False |
| 3022 | 1261 | 1261.0 | 27.8 | 27.8 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | False |
| 3023 | 3781 | 1260.3 | 92.3 | 30.8 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3024 | 1260 | 1260.0 | 28.2 | 28.2 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | False |
| 3025 | 1259 | 1259.0 | 28.9 | 28.9 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 3026 | 1259 | 1259.0 | 25.7 | 25.7 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | False |
| 3027 | 1259 | 1259.0 | 31.3 | 31.3 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | False |
| 3028 | 1259 | 1259.0 | 28.2 | 28.2 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | False |
| 3029 | 1259 | 1259.0 | 56.2 | 56.2 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | False |
| 3030 | 1258 | 1258.0 | 25.6 | 25.6 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 3031 | 1258 | 1258.0 | 24.6 | 24.6 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | False |
| 3032 | 1258 | 1258.0 | 26.2 | 26.2 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | False |
| 3033 | 11320 | 1257.8 | 278.2 | 30.9 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3034 | 2515 | 1257.5 | 33.6 | 16.8 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H VANDENDOOL, P D KRATZ | J Chromatogr | 1963 | 14062605 | Yes |
| 3035 | 2515 | 1257.5 | 69.1 | 34.5 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3036 | 3772 | 1257.3 | 94.9 | 31.6 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | False |
| 3037 | 2514 | 1257.0 | 80.1 | 40.0 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3038 | 2514 | 1257.0 | 74.2 | 37.1 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3039 | 1257 | 1257.0 | 35.9 | 35.9 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | False |
| 3040 | 2514 | 1257.0 | 57.7 | 28.9 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | False |
| 3041 | 12570 | 1257.0 | 307.3 | 30.7 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3042 | 2514 | 1257.0 | 58.2 | 29.1 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoît D'Autréaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | False |
| 3043 | 1257 | 1257.0 | 37.4 | 37.4 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 3044 | 1256 | 1256.0 | 27.9 | 27.9 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | False |
| 3045 | 1256 | 1256.0 | 29.7 | 29.7 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3046 | 1256 | 1256.0 | 43.9 | 43.9 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjöström | J Intern Med | 2013 | 23163728 | False |
| 3047 | 2512 | 1256.0 | 78.9 | 39.5 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | False |
| 3048 | 1255 | 1255.0 | 22.4 | 22.4 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 3049 | 1255 | 1255.0 | 45.5 | 45.5 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | False |
| 3050 | 1255 | 1255.0 | 21.5 | 21.5 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 3051 | 1255 | 1255.0 | 31.2 | 31.2 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | False |
| 3052 | 1255 | 1255.0 | 72.6 | 72.6 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D WINTER | Nature | 1962 | 14007593 | Yes |
| 3053 | 2510 | 1255.0 | 50.3 | 25.1 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | False |
| 3054 | 1254 | 1254.0 | 31.4 | 31.4 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | False |
| 3055 | 1254 | 1254.0 | 22.5 | 22.5 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | False |
| 3056 | 2507 | 1253.5 | 76.8 | 38.4 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 3057 | 1253 | 1253.0 | 30.7 | 30.7 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | False |
| 3058 | 1253 | 1253.0 | 42.1 | 42.1 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | False |
| 3059 | 1253 | 1253.0 | 39.1 | 39.1 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | False |
| 3060 | 1253 | 1253.0 | 32.1 | 32.1 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | False |
| 3061 | 3758 | 1252.7 | 107.4 | 35.8 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | False |
| 3062 | 2505 | 1252.5 | 91.2 | 45.6 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | False |
| 3063 | 5009 | 1252.2 | 115.4 | 28.9 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3064 | 2504 | 1252.0 | 57.6 | 28.8 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 3065 | 2504 | 1252.0 | 68.4 | 34.2 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | False |
| 3066 | 1252 | 1252.0 | 0.0 | 0.0 | A modification of receptor theory. | R P STEPHENSON | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 3067 | 1252 | 1252.0 | 34.9 | 34.9 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | False |
| 3068 | 2503 | 1251.5 | 56.6 | 28.3 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | False |
| 3069 | 2502 | 1251.0 | 64.8 | 32.4 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | False |
| 3070 | 1251 | 1251.0 | 40.4 | 40.4 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3071 | 3753 | 1251.0 | 107.2 | 35.7 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 3072 | 2502 | 1251.0 | 86.9 | 43.5 | Inflammasomes: mechanism of assembly, regulation and signalling. | Petr Broz, Vishva M Dixit | Nat Rev Immunol | 2016 | 27291964 | False |
| 3073 | 2501 | 1250.5 | 54.2 | 27.1 | The Polycomb complex PRC2 and its mark in life. | Raphaël Margueron, Danny Reinberg | Nature | 2011 | 21248841 | False |
| 3074 | 2501 | 1250.5 | 71.7 | 35.9 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | False |
| 3075 | 2499 | 1249.5 | 100.0 | 50.0 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3076 | 1249 | 1249.0 | 26.9 | 26.9 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | False |
| 3077 | 2498 | 1249.0 | 74.6 | 37.3 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | False |
| 3078 | 1249 | 1249.0 | 25.1 | 25.1 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | False |
| 3079 | 2498 | 1249.0 | 50.8 | 25.4 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | False |
| 3080 | 1249 | 1249.0 | 47.6 | 47.6 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 3081 | 3747 | 1249.0 | 88.3 | 29.4 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Gonçalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 3082 | 1249 | 1249.0 | 73.3 | 73.3 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 3083 | 2497 | 1248.5 | 78.7 | 39.4 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3084 | 2497 | 1248.5 | 51.6 | 25.8 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3085 | 1248 | 1248.0 | 22.7 | 22.7 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 3086 | 2496 | 1248.0 | 84.0 | 42.0 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3087 | 1248 | 1248.0 | 24.7 | 24.7 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | False |
| 3088 | 1248 | 1248.0 | 32.5 | 32.5 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | False |
| 3089 | 1248 | 1248.0 | 22.7 | 22.7 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | False |
| 3090 | 1248 | 1248.0 | 23.9 | 23.9 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3091 | 4989 | 1247.2 | 132.0 | 33.0 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | False |
| 3092 | 1247 | 1247.0 | 20.4 | 20.4 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | False |
| 3093 | 1247 | 1247.0 | 26.5 | 26.5 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3094 | 2494 | 1247.0 | 58.3 | 29.1 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | False |
| 3095 | 2493 | 1246.5 | 62.8 | 31.4 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | False |
| 3096 | 2493 | 1246.5 | 53.2 | 26.6 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | False |
| 3097 | 2492 | 1246.0 | 60.6 | 30.3 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | False |
| 3098 | 1246 | 1246.0 | 60.4 | 60.4 | Embracing the unknown: disentangling the complexities of the soil microbiome. | Noah Fierer | Nat Rev Microbiol | 2017 | 28824177 | False |
| 3099 | 1245 | 1245.0 | 44.4 | 44.4 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | False |
| 3100 | 1245 | 1245.0 | 24.7 | 24.7 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | False |
| 3101 | 1245 | 1245.0 | 27.4 | 27.4 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | False |
| 3102 | 1245 | 1245.0 | 26.3 | 26.3 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | False |
| 3103 | 1245 | 1245.0 | 26.3 | 26.3 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | False |
| 3104 | 1245 | 1245.0 | 33.7 | 33.7 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | False |
| 3105 | 2489 | 1244.5 | 48.3 | 24.1 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | False |
| 3106 | 2489 | 1244.5 | 47.6 | 23.8 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3107 | 2489 | 1244.5 | 76.8 | 38.4 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | False |
| 3108 | 3733 | 1244.3 | 104.2 | 34.7 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | Yes |
| 3109 | 2488 | 1244.0 | 64.2 | 32.1 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3110 | 1244 | 1244.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E MORTON | Am J Hum Genet | 1955 | 13258560 | Yes |
| 3111 | 2488 | 1244.0 | 57.5 | 28.8 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | False |
| 3112 | 1244 | 1244.0 | 31.6 | 31.6 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3113 | 2487 | 1243.5 | 49.8 | 24.9 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | False |
| 3114 | 1243 | 1243.0 | 36.1 | 36.1 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | False |
| 3115 | 1243 | 1243.0 | 30.4 | 30.4 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | False |
| 3116 | 1243 | 1243.0 | 29.2 | 29.2 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | False |
| 3117 | 2484 | 1242.0 | 65.9 | 33.0 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | False |
| 3118 | 1242 | 1242.0 | 42.0 | 42.0 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | False |
| 3119 | 1242 | 1242.0 | 38.0 | 38.0 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | False |
| 3120 | 2484 | 1242.0 | 56.8 | 28.4 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3121 | 1242 | 1242.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B MEDAWAR | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3122 | 1242 | 1242.0 | 33.8 | 33.8 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | False |
| 3123 | 1241 | 1241.0 | 35.5 | 35.5 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | False |
| 3124 | 1241 | 1241.0 | 25.2 | 25.2 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | False |
| 3125 | 2482 | 1241.0 | 70.6 | 35.3 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3126 | 1241 | 1241.0 | 31.9 | 31.9 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | False |
| 3127 | 1241 | 1241.0 | 40.8 | 40.8 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | False |
| 3128 | 2481 | 1240.5 | 51.6 | 25.8 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | False |
| 3129 | 2480 | 1240.0 | 61.0 | 30.5 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | False |
| 3130 | 2479 | 1239.5 | 64.2 | 32.1 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | False |
| 3131 | 1239 | 1239.0 | 33.7 | 33.7 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3132 | 1239 | 1239.0 | 29.1 | 29.1 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | False |
| 3133 | 1239 | 1239.0 | 25.5 | 25.5 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | False |
| 3134 | 7434 | 1239.0 | 166.0 | 27.7 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3135 | 1239 | 1239.0 | 31.8 | 31.8 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3136 | 2478 | 1239.0 | 53.0 | 26.5 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N AMES, D T DUBIN | J Biol Chem | 1960 | 13793161 | Yes |
| 3137 | 1238 | 1238.0 | 16.4 | 16.4 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M VAN ROSSUM | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 3138 | 1237 | 1237.0 | 55.4 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 3139 | 1237 | 1237.0 | 36.5 | 36.5 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | False |
| 3140 | 1237 | 1237.0 | 45.0 | 45.0 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | False |
| 3141 | 1237 | 1237.0 | 38.2 | 38.2 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | False |
| 3142 | 1237 | 1237.0 | 33.0 | 33.0 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | False |
| 3143 | 1237 | 1237.0 | 37.5 | 37.5 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 3144 | 1236 | 1236.0 | 48.7 | 48.7 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | False |
| 3145 | 1236 | 1236.0 | 31.7 | 31.7 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3146 | 3708 | 1236.0 | 90.9 | 30.3 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | False |
| 3147 | 1235 | 1235.0 | 39.3 | 39.3 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | False |
| 3148 | 1235 | 1235.0 | 59.6 | 59.6 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3149 | 1235 | 1235.0 | 62.3 | 62.3 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3150 | 2470 | 1235.0 | 48.0 | 24.0 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | False |
| 3151 | 3705 | 1235.0 | 105.3 | 35.1 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3152 | 6174 | 1234.8 | 191.3 | 38.3 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 3153 | 2469 | 1234.5 | 69.1 | 34.5 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 3154 | 1234 | 1234.0 | 46.0 | 46.0 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | False |
| 3155 | 2468 | 1234.0 | 39.3 | 19.6 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 3156 | 1234 | 1234.0 | 39.7 | 39.7 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | False |
| 3157 | 1234 | 1234.0 | 26.3 | 26.3 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | False |
| 3158 | 1234 | 1234.0 | 34.0 | 34.0 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | False |
| 3159 | 2468 | 1234.0 | 81.0 | 40.5 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 3160 | 2466 | 1233.0 | 52.0 | 26.0 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | False |
| 3161 | 3697 | 1232.3 | 84.3 | 28.1 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3162 | 2464 | 1232.0 | 67.5 | 33.8 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3163 | 1232 | 1232.0 | 15.5 | 15.5 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | False |
| 3164 | 2464 | 1232.0 | 52.3 | 26.1 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | False |
| 3165 | 1232 | 1232.0 | 30.0 | 30.0 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3166 | 2464 | 1232.0 | 65.1 | 32.5 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | False |
| 3167 | 2463 | 1231.5 | 63.3 | 31.6 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3168 | 7386 | 1231.0 | 135.1 | 22.5 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3169 | 1231 | 1231.0 | 25.8 | 25.8 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | False |
| 3170 | 2462 | 1231.0 | 107.9 | 54.0 | Activation of apoptosis signalling pathways by reactive oxygen species. | Maureen Redza-Dutordoir, Diana A Averill-Bates | Biochim Biophys Acta | 2016 | 27646922 | False |
| 3171 | 2460 | 1230.0 | 188.6 | 94.3 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3172 | 1230 | 1230.0 | 33.9 | 33.9 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 3173 | 2460 | 1230.0 | 95.7 | 47.9 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | False |
| 3174 | 1230 | 1230.0 | 25.3 | 25.3 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | False |
| 3175 | 1230 | 1230.0 | 45.6 | 45.6 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | False |
| 3176 | 1230 | 1230.0 | 51.1 | 51.1 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | False |
| 3177 | 2458 | 1229.0 | 117.0 | 58.5 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | False |
| 3178 | 1229 | 1229.0 | 31.9 | 31.9 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 3179 | 1229 | 1229.0 | 25.9 | 25.9 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | False |
| 3180 | 1229 | 1229.0 | 53.3 | 53.3 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | False |
| 3181 | 1229 | 1229.0 | 39.5 | 39.5 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | False |
| 3182 | 7373 | 1228.8 | 160.5 | 26.8 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3183 | 1228 | 1228.0 | 24.6 | 24.6 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | False |
| 3184 | 1228 | 1228.0 | 64.3 | 64.3 | Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. | Dimitrios Tsikas | Anal Biochem | 2017 | 27789233 | False |
| 3185 | 8592 | 1227.4 | 261.4 | 37.3 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3186 | 2454 | 1227.0 | 50.1 | 25.1 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | False |
| 3187 | 1227 | 1227.0 | 23.0 | 23.0 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | False |
| 3188 | 1227 | 1227.0 | 36.7 | 36.7 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | False |
| 3189 | 2453 | 1226.5 | 63.3 | 31.6 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | False |
| 3190 | 3679 | 1226.3 | 111.6 | 37.2 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3191 | 2452 | 1226.0 | 53.9 | 26.9 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 3192 | 1226 | 1226.0 | 35.8 | 35.8 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3193 | 1226 | 1226.0 | 20.9 | 20.9 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | False |
| 3194 | 3678 | 1226.0 | 96.2 | 32.1 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | False |
| 3195 | 3677 | 1225.7 | 86.7 | 28.9 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | False |
| 3196 | 1225 | 1225.0 | 25.0 | 25.0 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | False |
| 3197 | 1225 | 1225.0 | 30.5 | 30.5 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | False |
| 3198 | 1224 | 1224.0 | 28.4 | 28.4 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | False |
| 3199 | 1224 | 1224.0 | 33.8 | 33.8 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | False |
| 3200 | 1224 | 1224.0 | 22.1 | 22.1 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 3201 | 1224 | 1224.0 | 45.6 | 45.6 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | False |
| 3202 | 1224 | 1224.0 | 33.6 | 33.6 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | False |
| 3203 | 6117 | 1223.4 | 203.9 | 40.8 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3204 | 1223 | 1223.0 | 36.7 | 36.7 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | False |
| 3205 | 1223 | 1223.0 | 58.6 | 58.6 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | False |
| 3206 | 2446 | 1223.0 | 71.5 | 35.8 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3207 | 1223 | 1223.0 | 27.3 | 27.3 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | False |
| 3208 | 1223 | 1223.0 | 28.7 | 28.7 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | False |
| 3209 | 1223 | 1223.0 | 23.3 | 23.3 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | False |
| 3210 | 3668 | 1222.7 | 73.6 | 24.5 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | False |
| 3211 | 6111 | 1222.2 | 112.1 | 22.4 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | False |
| 3212 | 1222 | 1222.0 | 47.0 | 47.0 | A simple method for determination of serum catalase activity and revision of reference range. | L Góth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3213 | 1222 | 1222.0 | 34.6 | 34.6 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3214 | 1222 | 1222.0 | 22.2 | 22.2 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | False |
| 3215 | 1222 | 1222.0 | 30.1 | 30.1 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | False |
| 3216 | 1221 | 1221.0 | 27.8 | 27.8 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3217 | 1221 | 1221.0 | 74.5 | 74.5 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3218 | 1221 | 1221.0 | 25.8 | 25.8 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | False |
| 3219 | 1221 | 1221.0 | 26.7 | 26.7 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | False |
| 3220 | 4883 | 1220.8 | 174.2 | 43.5 | MultiQC: summarize analysis results for multiple tools and samples in a single report. | Philip Ewels, Måns Magnusson, Sverker Lundin, Max Käller | Bioinformatics | 2016 | 27312411 | Yes |
| 3221 | 2441 | 1220.5 | 68.0 | 34.0 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | False |
| 3222 | 2440 | 1220.0 | 69.1 | 34.5 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | False |
| 3223 | 1220 | 1220.0 | 30.5 | 30.5 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | False |
| 3224 | 3659 | 1219.7 | 60.7 | 20.2 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3225 | 3659 | 1219.7 | 71.1 | 23.7 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | False |
| 3226 | 1219 | 1219.0 | 25.0 | 25.0 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | False |
| 3227 | 1219 | 1219.0 | 27.0 | 27.0 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | False |
| 3228 | 1219 | 1219.0 | 32.7 | 32.7 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | False |
| 3229 | 2437 | 1218.5 | 51.9 | 25.9 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | False |
| 3230 | 1218 | 1218.0 | 24.7 | 24.7 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3231 | 1218 | 1218.0 | 40.8 | 40.8 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | False |
| 3232 | 1218 | 1218.0 | 58.7 | 58.7 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3233 | 1218 | 1218.0 | 37.2 | 37.2 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | False |
| 3234 | 1218 | 1218.0 | 23.7 | 23.7 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | False |
| 3235 | 1218 | 1218.0 | 26.3 | 26.3 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3236 | 1218 | 1218.0 | 30.4 | 30.4 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3237 | 2435 | 1217.5 | 29.8 | 14.9 | The Aggregation Of Blood Platelets. | G V BORN, M J CROSS | J Physiol | 1963 | 14056485 | Yes |
| 3238 | 2433 | 1216.5 | 82.5 | 41.2 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | False |
| 3239 | 1216 | 1216.0 | 29.1 | 29.1 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | False |
| 3240 | 2432 | 1216.0 | 89.8 | 44.9 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3241 | 2432 | 1216.0 | 89.1 | 44.5 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3242 | 3648 | 1216.0 | 101.7 | 33.9 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3243 | 1216 | 1216.0 | 23.6 | 23.6 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | False |
| 3244 | 1216 | 1216.0 | 22.7 | 22.7 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | False |
| 3245 | 1216 | 1216.0 | 28.2 | 28.2 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | False |
| 3246 | 1216 | 1216.0 | 31.7 | 31.7 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3247 | 1216 | 1216.0 | 51.7 | 51.7 | Overview of the IL-1 family in innate inflammation and acquired immunity. | Charles A Dinarello | Immunol Rev | 2018 | 29247995 | False |
| 3248 | 1215 | 1215.0 | 28.2 | 28.2 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3249 | 1215 | 1215.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A MERTON | J Physiol | 1954 | 13152698 | Yes |
| 3250 | 1215 | 1215.0 | 35.1 | 35.1 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | False |
| 3251 | 2429 | 1214.5 | 48.7 | 24.4 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | False |
| 3252 | 1214 | 1214.0 | 48.3 | 48.3 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | False |
| 3253 | 1214 | 1214.0 | 32.8 | 32.8 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | False |
| 3254 | 3642 | 1214.0 | 72.5 | 24.2 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3255 | 2428 | 1214.0 | 72.3 | 36.1 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3256 | 4855 | 1213.8 | 138.8 | 34.7 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3257 | 2426 | 1213.0 | 35.1 | 17.6 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3258 | 1213 | 1213.0 | 31.0 | 31.0 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | False |
| 3259 | 1213 | 1213.0 | 21.0 | 21.0 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat Rev Immunol | 2005 | 15928679 | False |
| 3260 | 2426 | 1213.0 | 113.1 | 56.5 | An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. | Jesper L R Andersson, Stamatios N Sotiropoulos | Neuroimage | 2016 | 26481672 | Yes |
| 3261 | 7273 | 1212.2 | 263.2 | 43.9 | ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. | James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling | J Chem Theory Comput | 2015 | 26574453 | Yes |
| 3262 | 1212 | 1212.0 | 26.3 | 26.3 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | False |
| 3263 | 1212 | 1212.0 | 45.4 | 45.4 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3264 | 2423 | 1211.5 | 53.7 | 26.9 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3265 | 2423 | 1211.5 | 71.0 | 35.5 | Crosstalk of reactive oxygen species and NF-κB signaling. | Michael J Morgan, Zheng-gang Liu | Cell Res | 2011 | 21187859 | False |
| 3266 | 2423 | 1211.5 | 75.6 | 37.8 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | False |
| 3267 | 2422 | 1211.0 | 71.2 | 35.6 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | False |
| 3268 | 1211 | 1211.0 | 29.0 | 29.0 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | False |
| 3269 | 1211 | 1211.0 | 25.0 | 25.0 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | False |
| 3270 | 2421 | 1210.5 | 67.8 | 33.9 | Mitochondria: in sickness and in health. | Jodi Nunnari, Anu Suomalainen | Cell | 2012 | 22424226 | False |
| 3271 | 3631 | 1210.3 | 112.3 | 37.4 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | False |
| 3272 | 1210 | 1210.0 | 52.5 | 52.5 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3273 | 3630 | 1210.0 | 102.5 | 34.2 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3274 | 1210 | 1210.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G BUONOCORE | J Dent Res | 1955 | 13271655 | Yes |
| 3275 | 2418 | 1209.0 | 64.1 | 32.0 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | False |
| 3276 | 1209 | 1209.0 | 30.2 | 30.2 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | False |
| 3277 | 1209 | 1209.0 | 28.0 | 28.0 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | False |
| 3278 | 1209 | 1209.0 | 32.6 | 32.6 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | False |
| 3279 | 1209 | 1209.0 | 39.0 | 39.0 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | False |
| 3280 | 1208 | 1208.0 | 28.0 | 28.0 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3281 | 1208 | 1208.0 | 25.6 | 25.6 | Human papillomavirus and cervical cancer. | Eileen M Burd | Clin Microbiol Rev | 2003 | 12525422 | False |
| 3282 | 1208 | 1208.0 | 23.7 | 23.7 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | False |
| 3283 | 1207 | 1207.0 | 38.5 | 38.5 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | False |
| 3284 | 1207 | 1207.0 | 31.4 | 31.4 | Philosophical conceptions of the self: implications for cognitive science. | I Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3285 | 1207 | 1207.0 | 24.3 | 24.3 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | False |
| 3286 | 1207 | 1207.0 | 28.6 | 28.6 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | False |
| 3287 | 1206 | 1206.0 | 56.1 | 56.1 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3288 | 2412 | 1206.0 | 59.2 | 29.6 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3289 | 1206 | 1206.0 | 29.0 | 29.0 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | False |
| 3290 | 2412 | 1206.0 | 66.8 | 33.4 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3291 | 1205 | 1205.0 | 35.9 | 35.9 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | False |
| 3292 | 2409 | 1204.5 | 103.9 | 52.0 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3293 | 2409 | 1204.5 | 48.7 | 24.4 | TM-align: a protein structure alignment algorithm based on the TM-score. | Yang Zhang, Jeffrey Skolnick | Nucleic Acids Res | 2005 | 15849316 | Yes |
| 3294 | 2408 | 1204.0 | 82.5 | 41.2 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | False |
| 3295 | 1204 | 1204.0 | 18.6 | 18.6 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3296 | 2408 | 1204.0 | 53.1 | 26.6 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3297 | 1204 | 1204.0 | 109.3 | 109.3 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3298 | 1204 | 1204.0 | 25.5 | 25.5 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3299 | 2407 | 1203.5 | 87.7 | 43.9 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3300 | 2407 | 1203.5 | 54.4 | 27.2 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | False |
| 3301 | 2407 | 1203.5 | 52.3 | 26.1 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | False |
| 3302 | 1203 | 1203.0 | 50.2 | 50.2 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3303 | 1203 | 1203.0 | 41.2 | 41.2 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3304 | 2406 | 1203.0 | 63.6 | 31.8 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | False |
| 3305 | 2406 | 1203.0 | 42.5 | 21.2 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | False |
| 3306 | 6012 | 1202.4 | 231.8 | 46.4 | Frailty in elderly people. | Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood | Lancet | 2013 | 23395245 | False |
| 3307 | 1202 | 1202.0 | 37.8 | 37.8 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | False |
| 3308 | 1201 | 1201.0 | 29.9 | 29.9 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3309 | 1201 | 1201.0 | 26.8 | 26.8 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | False |
| 3310 | 6004 | 1200.8 | 282.8 | 56.6 | Using the framework method for the analysis of qualitative data in multi-disciplinary health research. | Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood | BMC Med Res Methodol | 2013 | 24047204 | Yes |
| 3311 | 6003 | 1200.6 | 161.5 | 32.3 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3312 | 6002 | 1200.4 | 141.3 | 28.3 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3313 | 1200 | 1200.0 | 30.0 | 30.0 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | False |
| 3314 | 1200 | 1200.0 | 19.2 | 19.2 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | False |
| 3315 | 2400 | 1200.0 | 81.6 | 40.8 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | False |
| 3316 | 3599 | 1199.7 | 93.3 | 31.1 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3317 | 1199 | 1199.0 | 48.9 | 48.9 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | False |
| 3318 | 1199 | 1199.0 | 23.6 | 23.6 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3319 | 1199 | 1199.0 | 25.7 | 25.7 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3320 | 1199 | 1199.0 | 32.1 | 32.1 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3321 | 4795 | 1198.8 | 90.4 | 22.6 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3322 | 8390 | 1198.6 | 242.2 | 34.6 | pROC: an open-source package for R and S+ to analyze and compare ROC curves. | Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frédérique Lisacek, Jean-Charles Sanchez, Markus Müller | BMC Bioinformatics | 2011 | 21414208 | Yes |
| 3323 | 2396 | 1198.0 | 77.1 | 38.5 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3324 | 2396 | 1198.0 | 80.7 | 40.4 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | False |
| 3325 | 2395 | 1197.5 | 56.4 | 28.2 | Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. | In Suk Joung, Thomas E Cheatham | J Phys Chem B | 2008 | 18593145 | Yes |
| 3326 | 3592 | 1197.3 | 110.1 | 36.7 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3327 | 1197 | 1197.0 | 36.5 | 36.5 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | False |
| 3328 | 1197 | 1197.0 | 25.4 | 25.4 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | False |
| 3329 | 1197 | 1197.0 | 28.9 | 28.9 | Identifying and characterizing binding sites and assessing druggability. | Thomas A Halgren | J Chem Inf Model | 2009 | 19434839 | Yes |
| 3330 | 3590 | 1196.7 | 91.4 | 30.5 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3331 | 3590 | 1196.7 | 85.7 | 28.6 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | False |
| 3332 | 7180 | 1196.7 | 276.7 | 46.1 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3333 | 2392 | 1196.0 | 87.2 | 43.6 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3334 | 2392 | 1196.0 | 45.8 | 22.9 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | False |
| 3335 | 1196 | 1196.0 | 17.7 | 17.7 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E HOPE-SIMPSON | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3336 | 2392 | 1196.0 | 60.8 | 30.4 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | False |
| 3337 | 10761 | 1195.7 | 352.5 | 39.2 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3338 | 1195 | 1195.0 | 28.4 | 28.4 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3339 | 1195 | 1195.0 | 21.3 | 21.3 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3340 | 1195 | 1195.0 | 62.4 | 62.4 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3341 | 2390 | 1195.0 | 51.7 | 25.9 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3342 | 2389 | 1194.5 | 68.2 | 34.1 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | False |
| 3343 | 1194 | 1194.0 | 20.4 | 20.4 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | False |
| 3344 | 7163 | 1193.8 | 242.9 | 40.5 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3345 | 3580 | 1193.3 | 72.0 | 24.0 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | False |
| 3346 | 1193 | 1193.0 | 40.3 | 40.3 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3347 | 1193 | 1193.0 | 45.2 | 45.2 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | False |
| 3348 | 1193 | 1193.0 | 32.6 | 32.6 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | False |
| 3349 | 1193 | 1193.0 | 33.8 | 33.8 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | False |
| 3350 | 2386 | 1193.0 | 61.3 | 30.6 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3351 | 3579 | 1193.0 | 73.5 | 24.5 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | False |
| 3352 | 3579 | 1193.0 | 91.2 | 30.4 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3353 | 4770 | 1192.5 | 106.3 | 26.6 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3354 | 1192 | 1192.0 | 33.4 | 33.4 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3355 | 1192 | 1192.0 | 22.4 | 22.4 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | False |
| 3356 | 1192 | 1192.0 | 32.5 | 32.5 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | False |
| 3357 | 3574 | 1191.3 | 124.9 | 41.6 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3358 | 2382 | 1191.0 | 95.5 | 47.8 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3359 | 1191 | 1191.0 | 29.4 | 29.4 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | False |
| 3360 | 1191 | 1191.0 | 46.8 | 46.8 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | False |
| 3361 | 8335 | 1190.7 | 160.5 | 22.9 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3362 | 2381 | 1190.5 | 68.3 | 34.1 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3363 | 2381 | 1190.5 | 56.9 | 28.4 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3364 | 2380 | 1190.0 | 48.2 | 24.1 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | False |
| 3365 | 1190 | 1190.0 | 23.4 | 23.4 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G DUNCOMBE | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3366 | 2380 | 1190.0 | 44.1 | 22.1 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | False |
| 3367 | 2379 | 1189.5 | 46.1 | 23.1 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3368 | 2379 | 1189.5 | 139.8 | 69.9 | Sarcopenia. | Alfonso J Cruz-Jentoft, Avan A Sayer | Lancet | 2019 | 31171417 | False |
| 3369 | 1189 | 1189.0 | 68.2 | 68.2 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | False |
| 3370 | 2378 | 1189.0 | 48.1 | 24.1 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | False |
| 3371 | 1189 | 1189.0 | 31.4 | 31.4 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | Yes |
| 3372 | 2377 | 1188.5 | 96.3 | 48.1 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | False |
| 3373 | 1188 | 1188.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3374 | 1188 | 1188.0 | 32.4 | 32.4 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | False |
| 3375 | 1188 | 1188.0 | 32.8 | 32.8 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | False |
| 3376 | 3562 | 1187.3 | 165.5 | 55.2 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3377 | 11872 | 1187.2 | 383.7 | 38.4 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3378 | 1187 | 1187.0 | 31.0 | 31.0 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | False |
| 3379 | 1187 | 1187.0 | 34.0 | 34.0 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | False |
| 3380 | 1187 | 1187.0 | 12.6 | 12.6 | A New Serum Type System In Man--The Lp System. | K BERG | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3381 | 16612 | 1186.6 | 351.3 | 25.1 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3382 | 2373 | 1186.5 | 50.4 | 25.2 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | False |
| 3383 | 7119 | 1186.5 | 159.9 | 26.7 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3384 | 2372 | 1186.0 | 111.3 | 55.6 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3385 | 1186 | 1186.0 | 27.4 | 27.4 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | False |
| 3386 | 2372 | 1186.0 | 49.0 | 24.5 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | False |
| 3387 | 3557 | 1185.7 | 79.4 | 26.5 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3388 | 2371 | 1185.5 | 43.3 | 21.6 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | False |
| 3389 | 5926 | 1185.2 | 191.6 | 38.3 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | False |
| 3390 | 2370 | 1185.0 | 37.4 | 18.7 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3391 | 1185 | 1185.0 | 80.2 | 80.2 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3392 | 1185 | 1185.0 | 43.8 | 43.8 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3393 | 1185 | 1185.0 | 39.4 | 39.4 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | False |
| 3394 | 1185 | 1185.0 | 41.6 | 41.6 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3395 | 1185 | 1185.0 | 29.2 | 29.2 | Seed Germination and Dormancy. | J. D. Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3396 | 2370 | 1185.0 | 52.4 | 26.2 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3397 | 1185 | 1185.0 | 23.2 | 23.2 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B ASHWORTH | Practitioner | 1964 | 14143329 | Yes |
| 3398 | 1185 | 1185.0 | 25.1 | 25.1 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | False |
| 3399 | 2370 | 1185.0 | 70.3 | 35.1 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | False |
| 3400 | 1184 | 1184.0 | 30.4 | 30.4 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | False |
| 3401 | 7100 | 1183.3 | 149.9 | 25.0 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3402 | 1183 | 1183.0 | 37.3 | 37.3 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3403 | 2366 | 1183.0 | 49.6 | 24.8 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | False |
| 3404 | 3547 | 1182.3 | 197.6 | 65.9 | Improved metagenomic analysis with Kraken 2. | Derrick E Wood, Jennifer Lu, Ben Langmead | Genome Biol | 2019 | 31779668 | Yes |
| 3405 | 4729 | 1182.2 | 109.3 | 27.3 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3406 | 1182 | 1182.0 | 38.9 | 38.9 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | False |
| 3407 | 1182 | 1182.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C CHANG | Nature | 1951 | 14882325 | Yes |
| 3408 | 2364 | 1182.0 | 88.0 | 44.0 | Comparative Protein Structure Modeling Using MODELLER. | Benjamin Webb, Andrej Sali | Curr Protoc Bioinformatics | 2016 | 27322406 | Yes |
| 3409 | 2363 | 1181.5 | 49.7 | 24.9 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3410 | 1181 | 1181.0 | 36.2 | 36.2 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | False |
| 3411 | 1181 | 1181.0 | 26.3 | 26.3 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | False |
| 3412 | 1181 | 1181.0 | 22.0 | 22.0 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | False |
| 3413 | 2362 | 1181.0 | 67.8 | 33.9 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | False |
| 3414 | 11809 | 1180.9 | 262.0 | 26.2 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3415 | 3542 | 1180.7 | 75.9 | 25.3 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | False |
| 3416 | 2360 | 1180.0 | 64.9 | 32.5 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | False |
| 3417 | 1180 | 1180.0 | 11.7 | 11.7 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3418 | 1180 | 1180.0 | 26.7 | 26.7 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3419 | 1180 | 1180.0 | 33.9 | 33.9 | pegas: an R package for population genetics with an integrated-modular approach. | Emmanuel Paradis | Bioinformatics | 2010 | 20080509 | Yes |
| 3420 | 2360 | 1180.0 | 64.4 | 32.2 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. | Marie Cargnello, Philippe P Roux | Microbiol Mol Biol Rev | 2011 | 21372320 | False |
| 3421 | 1180 | 1180.0 | 40.7 | 40.7 | Human milk oligosaccharides: every baby needs a sugar mama. | Lars Bode | Glycobiology | 2012 | 22513036 | False |
| 3422 | 2359 | 1179.5 | 49.5 | 24.8 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | False |
| 3423 | 2358 | 1179.0 | 73.7 | 36.9 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | False |
| 3424 | 3537 | 1179.0 | 70.6 | 23.5 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3425 | 1179 | 1179.0 | 32.9 | 32.9 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | False |
| 3426 | 2358 | 1179.0 | 100.9 | 50.5 | Designing hydrogels for controlled drug delivery. | Jianyu Li, David J Mooney | Nat Rev Mater | 2016 | 29657852 | Yes |
| 3427 | 4714 | 1178.5 | 113.5 | 28.4 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3428 | 1178 | 1178.0 | 51.5 | 51.5 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3429 | 1178 | 1178.0 | 34.7 | 34.7 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | False |
| 3430 | 3534 | 1178.0 | 79.9 | 26.6 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernán, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3431 | 1178 | 1178.0 | 31.2 | 31.2 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3432 | 2356 | 1178.0 | 56.8 | 28.4 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | False |
| 3433 | 1178 | 1178.0 | 29.6 | 29.6 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3434 | 2355 | 1177.5 | 120.9 | 60.5 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3435 | 2355 | 1177.5 | 102.4 | 51.2 | Principal component analysis: a review and recent developments. | Ian T Jolliffe, Jorge Cadima | Philos Trans A Math Phys Eng Sci | 2016 | 26953178 | False |
| 3436 | 1177 | 1177.0 | 20.7 | 20.7 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3437 | 1177 | 1177.0 | 27.1 | 27.1 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3438 | 2353 | 1176.5 | 42.8 | 21.4 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3439 | 1176 | 1176.0 | 22.1 | 22.1 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | False |
| 3440 | 2352 | 1176.0 | 56.1 | 28.1 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | False |
| 3441 | 1176 | 1176.0 | 22.7 | 22.7 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | False |
| 3442 | 2352 | 1176.0 | 63.8 | 31.9 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | False |
| 3443 | 2351 | 1175.5 | 51.4 | 25.7 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | False |
| 3444 | 1175 | 1175.0 | 34.2 | 34.2 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | False |
| 3445 | 1175 | 1175.0 | 31.8 | 31.8 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | False |
| 3446 | 1175 | 1175.0 | 30.7 | 30.7 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | False |
| 3447 | 1175 | 1175.0 | 42.3 | 42.3 | Type 2 inflammation in asthma--present in most, absent in many. | John V Fahy | Nat Rev Immunol | 2015 | 25534623 | False |
| 3448 | 2349 | 1174.5 | 51.3 | 25.6 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3449 | 3523 | 1174.3 | 92.8 | 30.9 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3450 | 1174 | 1174.0 | 57.7 | 57.7 | Osseointegration and its experimental background. | P I Brånemark | J Prosthet Dent | 1983 | 6352924 | False |
| 3451 | 1173 | 1173.0 | 36.6 | 36.6 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | False |
| 3452 | 1173 | 1173.0 | 23.9 | 23.9 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3453 | 1173 | 1173.0 | 31.9 | 31.9 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | False |
| 3454 | 2346 | 1173.0 | 66.5 | 33.2 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | False |
| 3455 | 3518 | 1172.7 | 93.0 | 31.0 | FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | Mol Biol Evol | 2009 | 19377059 | Yes |
| 3456 | 2345 | 1172.5 | 63.9 | 31.9 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | False |
| 3457 | 2345 | 1172.5 | 50.1 | 25.1 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | False |
| 3458 | 2345 | 1172.5 | 55.5 | 27.8 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | False |
| 3459 | 2344 | 1172.0 | 74.6 | 37.3 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | False |
| 3460 | 1172 | 1172.0 | 30.6 | 30.6 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3461 | 1171 | 1171.0 | 26.1 | 26.1 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | False |
| 3462 | 1171 | 1171.0 | 36.7 | 36.7 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan St B T Evans | Annu Rev Psychol | 2008 | 18154502 | False |
| 3463 | 1171 | 1171.0 | 38.3 | 38.3 | Epidemiology of heart failure. | Véronique L Roger | Circ Res | 2013 | 23989710 | False |
| 3464 | 2341 | 1170.5 | 105.0 | 52.5 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3465 | 2341 | 1170.5 | 67.5 | 33.8 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | False |
| 3466 | 1170 | 1170.0 | 34.9 | 34.9 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | False |
| 3467 | 1170 | 1170.0 | 31.8 | 31.8 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | False |
| 3468 | 1170 | 1170.0 | 36.8 | 36.8 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3469 | 1170 | 1170.0 | 0.0 | 0.0 | The powerful placebo. | H K BEECHER | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3470 | 1170 | 1170.0 | 26.3 | 26.3 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | False |
| 3471 | 1170 | 1170.0 | 33.8 | 33.8 | The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. | John Duncan | Trends Cogn Sci | 2010 | 20171926 | False |
| 3472 | 3507 | 1169.0 | 140.9 | 47.0 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3473 | 1169 | 1169.0 | 29.0 | 29.0 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | False |
| 3474 | 1169 | 1169.0 | 23.4 | 23.4 | Searching for intellectual turning points: progressive knowledge domain visualization. | Chaomei Chen | Proc Natl Acad Sci U S A | 2004 | 14724295 | Yes |
| 3475 | 1169 | 1169.0 | 26.9 | 26.9 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | False |
| 3476 | 1169 | 1169.0 | 33.5 | 33.5 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | False |
| 3477 | 1169 | 1169.0 | 36.6 | 36.6 | The inflammatory response in myocardial injury, repair, and remodelling. | Nikolaos G Frangogiannis | Nat Rev Cardiol | 2014 | 24663091 | False |
| 3478 | 3506 | 1168.7 | 95.9 | 32.0 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3479 | 9347 | 1168.4 | 286.0 | 35.8 | Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. | V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks | Am J Prev Med | 1998 | 9635069 | Yes |
| 3480 | 1168 | 1168.0 | 39.1 | 39.1 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | False |
| 3481 | 1168 | 1168.0 | 53.0 | 53.0 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3482 | 1168 | 1168.0 | 11.5 | 11.5 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3483 | 3504 | 1168.0 | 118.6 | 39.5 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | False |
| 3484 | 2336 | 1168.0 | 102.2 | 51.1 | The role of inflammation in depression: from evolutionary imperative to modern treatment target. | Andrew H Miller, Charles L Raison | Nat Rev Immunol | 2016 | 26711676 | False |
| 3485 | 2335 | 1167.5 | 84.4 | 42.2 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3486 | 2335 | 1167.5 | 66.9 | 33.5 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | False |
| 3487 | 4669 | 1167.2 | 121.8 | 30.4 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3488 | 1167 | 1167.0 | 55.6 | 55.6 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | False |
| 3489 | 1167 | 1167.0 | 39.4 | 39.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3490 | 1167 | 1167.0 | 28.3 | 28.3 | Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" | F D Haldane | Phys Rev Lett | 1988 | 10038961 | Yes |
| 3491 | 2334 | 1167.0 | 76.8 | 38.4 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | False |
| 3492 | 2334 | 1167.0 | 47.0 | 23.5 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3493 | 2334 | 1167.0 | 39.5 | 19.8 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3494 | 3498 | 1166.0 | 80.4 | 26.8 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3495 | 2332 | 1166.0 | 43.5 | 21.8 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | False |
| 3496 | 1166 | 1166.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B REXED | J Comp Neurol | 1952 | 14946260 | Yes |
| 3497 | 1166 | 1166.0 | 34.1 | 34.1 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bünzli | Chem Rev | 2010 | 20151630 | False |
| 3498 | 2331 | 1165.5 | 56.0 | 28.0 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | False |
| 3499 | 2331 | 1165.5 | 75.1 | 37.5 | Toll-like receptor signaling pathways. | Takumi Kawasaki, Taro Kawai | Front Immunol | 2014 | 25309543 | False |
| 3500 | 1165 | 1165.0 | 30.4 | 30.4 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3501 | 1165 | 1165.0 | 25.7 | 25.7 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3502 | 2330 | 1165.0 | 55.7 | 27.9 | Interaction revisited: the difference between two estimates. | Douglas G Altman, J Martin Bland | BMJ | 2003 | 12543843 | False |
| 3503 | 1165 | 1165.0 | 21.3 | 21.3 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | False |
| 3504 | 1164 | 1164.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B BROWN | Biochem J | 1955 | 14389222 | Yes |
| 3505 | 2327 | 1163.5 | 57.5 | 28.8 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | False |
| 3506 | 1163 | 1163.0 | 33.9 | 33.9 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | False |
| 3507 | 1163 | 1163.0 | 33.5 | 33.5 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | False |
| 3508 | 1163 | 1163.0 | 31.3 | 31.3 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | False |
| 3509 | 1163 | 1163.0 | 28.9 | 28.9 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | False |
| 3510 | 1163 | 1163.0 | 24.0 | 24.0 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | False |
| 3511 | 1163 | 1163.0 | 26.3 | 26.3 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | False |
| 3512 | 1163 | 1163.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J FAIRBANK | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3513 | 2325 | 1162.5 | 50.5 | 25.2 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | False |
| 3514 | 1162 | 1162.0 | 42.5 | 42.5 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | False |
| 3515 | 1162 | 1162.0 | 20.8 | 20.8 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | False |
| 3516 | 1162 | 1162.0 | 32.0 | 32.0 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | False |
| 3517 | 1162 | 1162.0 | 34.6 | 34.6 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | False |
| 3518 | 1162 | 1162.0 | 23.0 | 23.0 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | False |
| 3519 | 1162 | 1162.0 | 30.6 | 30.6 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | False |
| 3520 | 1162 | 1162.0 | 52.4 | 52.4 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3521 | 5808 | 1161.6 | 207.3 | 41.5 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3522 | 4646 | 1161.5 | 120.4 | 30.1 | Mussel-inspired surface chemistry for multifunctional coatings. | Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith | Science | 2007 | 17947576 | Yes |
| 3523 | 2323 | 1161.5 | 93.8 | 46.9 | Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. | T J Cole, T Lobstein | Pediatr Obes | 2012 | 22715120 | Yes |
| 3524 | 1161 | 1161.0 | 61.4 | 61.4 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3525 | 1161 | 1161.0 | 26.6 | 26.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | False |
| 3526 | 2322 | 1161.0 | 63.2 | 31.6 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3527 | 1161 | 1161.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E BULBRING | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3528 | 1160 | 1160.0 | 52.5 | 52.5 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3529 | 1160 | 1160.0 | 43.1 | 43.1 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3530 | 1160 | 1160.0 | 31.4 | 31.4 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | False |
| 3531 | 1160 | 1160.0 | 28.4 | 28.4 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | False |
| 3532 | 1160 | 1160.0 | 28.1 | 28.1 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | False |
| 3533 | 3478 | 1159.3 | 117.2 | 39.1 | Ecological momentary assessment. | Saul Shiffman, Arthur A Stone, Michael R Hufford | Annu Rev Clin Psychol | 2008 | 18509902 | False |
| 3534 | 2318 | 1159.0 | 66.6 | 33.3 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3535 | 1159 | 1159.0 | 42.7 | 42.7 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | False |
| 3536 | 2318 | 1159.0 | 72.7 | 36.4 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | False |
| 3537 | 5794 | 1158.8 | 113.3 | 22.7 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3538 | 3475 | 1158.3 | 176.8 | 58.9 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3539 | 2316 | 1158.0 | 131.7 | 65.8 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W BUTCHER, E W SUTHERLAND | J Biol Chem | 1962 | 13875173 | Yes |
| 3540 | 1158 | 1158.0 | 24.0 | 24.0 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | False |
| 3541 | 1157 | 1157.0 | 24.4 | 24.4 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3542 | 1157 | 1157.0 | 24.3 | 24.3 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3543 | 2314 | 1157.0 | 49.2 | 24.6 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | False |
| 3544 | 1157 | 1157.0 | 30.3 | 30.3 | Inflammation 2010: new adventures of an old flame. | Ruslan Medzhitov | Cell | 2010 | 20303867 | False |
| 3545 | 12723 | 1156.6 | 236.4 | 21.5 | Model-based analysis of ChIP-Seq (MACS). | Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu | Genome Biol | 2008 | 18798982 | Yes |
| 3546 | 1156 | 1156.0 | 24.3 | 24.3 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3547 | 1156 | 1156.0 | 38.3 | 38.3 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3548 | 3467 | 1155.7 | 84.2 | 28.1 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3549 | 2311 | 1155.5 | 46.9 | 23.4 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3550 | 2311 | 1155.5 | 91.5 | 45.8 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. | Michael A Gimbrone, Guillermo García-Cardeña | Circ Res | 2016 | 26892962 | False |
| 3551 | 2310 | 1155.0 | 70.3 | 35.1 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | False |
| 3552 | 2310 | 1155.0 | 93.8 | 46.9 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3553 | 1155 | 1155.0 | 21.6 | 21.6 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | False |
| 3554 | 1155 | 1155.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J VAGUE | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3555 | 1155 | 1155.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R VANE | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3556 | 1155 | 1155.0 | 33.9 | 33.9 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | False |
| 3557 | 9235 | 1154.4 | 425.1 | 53.1 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. | Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda | Nat Commun | 2019 | 30944313 | Yes |
| 3558 | 1154 | 1154.0 | 29.3 | 29.3 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3559 | 1154 | 1154.0 | 33.0 | 33.0 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3560 | 1154 | 1154.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3561 | 1154 | 1154.0 | 27.8 | 27.8 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | False |
| 3562 | 3460 | 1153.3 | 89.2 | 29.7 | Fluorine in pharmaceuticals: looking beyond intuition. | Klaus Müller, Christoph Faeh, François Diederich | Science | 2007 | 17901324 | False |
| 3563 | 3460 | 1153.3 | 137.9 | 46.0 | Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. | Antonio Ayala, Mario F Muñoz, Sandro Argüelles | Oxid Med Cell Longev | 2014 | 24999379 | False |
| 3564 | 1153 | 1153.0 | 20.4 | 20.4 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | False |
| 3565 | 1153 | 1153.0 | 34.8 | 34.8 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3566 | 1153 | 1153.0 | 34.0 | 34.0 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3567 | 1152 | 1152.0 | 31.6 | 31.6 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | False |
| 3568 | 2303 | 1151.5 | 46.1 | 23.1 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 3569 | 2303 | 1151.5 | 60.8 | 30.4 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3570 | 2303 | 1151.5 | 49.2 | 24.6 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | False |
| 3571 | 1151 | 1151.0 | 34.8 | 34.8 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | False |
| 3572 | 1151 | 1151.0 | 30.2 | 30.2 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3573 | 1151 | 1151.0 | 22.0 | 22.0 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | False |
| 3574 | 1151 | 1151.0 | 29.5 | 29.5 | The quantum internet. | H J Kimble | Nature | 2008 | 18563153 | Yes |
| 3575 | 1151 | 1151.0 | 29.5 | 29.5 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | False |
| 3576 | 1151 | 1151.0 | 43.6 | 43.6 | The angular gyrus: multiple functions and multiple subdivisions. | Mohamed L Seghier | Neuroscientist | 2013 | 22547530 | False |
| 3577 | 2302 | 1151.0 | 76.6 | 38.3 | The gut microbiota--masters of host development and physiology. | Felix Sommer, Fredrik Bäckhed | Nat Rev Microbiol | 2013 | 23435359 | False |
| 3578 | 1151 | 1151.0 | 33.0 | 33.0 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | False |
| 3579 | 4604 | 1151.0 | 248.9 | 62.2 | Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. | Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun | IEEE Trans Pattern Anal Mach Intell | 2017 | 27295650 | Yes |
| 3580 | 3451 | 1150.3 | 72.7 | 24.2 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3581 | 2300 | 1150.0 | 48.2 | 24.1 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3582 | 2300 | 1150.0 | 58.7 | 29.4 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | False |
| 3583 | 1150 | 1150.0 | 33.5 | 33.5 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3584 | 1150 | 1150.0 | 25.9 | 25.9 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | False |
| 3585 | 3450 | 1150.0 | 73.3 | 24.4 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3586 | 3448 | 1149.3 | 117.1 | 39.0 | Social relationships and mortality risk: a meta-analytic review. | Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton | PLoS Med | 2010 | 20668659 | False |
| 3587 | 1149 | 1149.0 | 30.9 | 30.9 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | False |
| 3588 | 1149 | 1149.0 | 37.2 | 37.2 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | False |
| 3589 | 1149 | 1149.0 | 21.1 | 21.1 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | False |
| 3590 | 1149 | 1149.0 | 48.0 | 48.0 | Mediation Analysis: A Practitioner's Guide. | Tyler J VanderWeele | Annu Rev Public Health | 2016 | 26653405 | False |
| 3591 | 1148 | 1148.0 | 34.3 | 34.3 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3592 | 1148 | 1148.0 | 32.0 | 32.0 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | False |
| 3593 | 2296 | 1148.0 | 88.6 | 44.3 | Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. | N L Glass, G C Donaldson | Appl Environ Microbiol | 1995 | 7747954 | Yes |
| 3594 | 1148 | 1148.0 | 23.9 | 23.9 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | False |
| 3595 | 1148 | 1148.0 | 25.4 | 25.4 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | False |
| 3596 | 2296 | 1148.0 | 87.7 | 43.9 | Tumour heterogeneity and resistance to cancer therapies. | Ibiayi Dagogo-Jack, Alice T Shaw | Nat Rev Clin Oncol | 2018 | 29115304 | False |
| 3597 | 6887 | 1147.8 | 177.7 | 29.6 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3598 | 2295 | 1147.5 | 68.5 | 34.2 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3599 | 1147 | 1147.0 | 21.6 | 21.6 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | False |
| 3600 | 1147 | 1147.0 | 21.7 | 21.7 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 3601 | 1147 | 1147.0 | 32.3 | 32.3 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | False |
| 3602 | 1147 | 1147.0 | 23.2 | 23.2 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | False |
| 3603 | 1147 | 1147.0 | 21.8 | 21.8 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | False |
| 3604 | 1147 | 1147.0 | 23.9 | 23.9 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3605 | 3441 | 1147.0 | 122.4 | 40.8 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. | Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott | Physiol Rev | 2014 | 24987008 | False |
| 3606 | 2293 | 1146.5 | 50.5 | 25.2 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | False |
| 3607 | 4586 | 1146.5 | 109.9 | 27.5 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 3608 | 3439 | 1146.3 | 134.3 | 44.8 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3609 | 2292 | 1146.0 | 66.5 | 33.2 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | False |
| 3610 | 1146 | 1146.0 | 24.0 | 24.0 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | False |
| 3611 | 1146 | 1146.0 | 33.2 | 33.2 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3612 | 1146 | 1146.0 | 26.7 | 26.7 | Matrix eQTL: ultra fast eQTL analysis via large matrix operations. | Andrey A Shabalin | Bioinformatics | 2012 | 22492648 | Yes |
| 3613 | 2291 | 1145.5 | 76.6 | 38.3 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N Engl J Med | 1992 | 1307234 | Yes |
| 3614 | 2291 | 1145.5 | 46.6 | 23.3 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3615 | 2291 | 1145.5 | 60.6 | 30.3 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3616 | 1145 | 1145.0 | 27.1 | 27.1 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3617 | 1145 | 1145.0 | 20.2 | 20.2 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | False |
| 3618 | 1145 | 1145.0 | 25.7 | 25.7 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | False |
| 3619 | 1145 | 1145.0 | 29.9 | 29.9 | Neural stimulation and recording electrodes. | Stuart F Cogan | Annu Rev Biomed Eng | 2008 | 18429704 | False |
| 3620 | 1145 | 1145.0 | 28.2 | 28.2 | Overview of the immune response. | David D Chaplin | J Allergy Clin Immunol | 2010 | 20176265 | False |
| 3621 | 4578 | 1144.5 | 107.4 | 26.9 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3622 | 1144 | 1144.0 | 31.1 | 31.1 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3623 | 1144 | 1144.0 | 20.9 | 20.9 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | False |
| 3624 | 1144 | 1144.0 | 28.3 | 28.3 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | False |
| 3625 | 2288 | 1144.0 | 60.4 | 30.2 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. | Maria M Mihaylova, Reuben J Shaw | Nat Cell Biol | 2011 | 21892142 | False |
| 3626 | 1144 | 1144.0 | 39.7 | 39.7 | DREADDs for Neuroscientists. | Bryan L Roth | Neuron | 2016 | 26889809 | False |
| 3627 | 1143 | 1143.0 | 44.1 | 44.1 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3628 | 2286 | 1143.0 | 44.3 | 22.1 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | False |
| 3629 | 1143 | 1143.0 | 28.6 | 28.6 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 3630 | 2286 | 1143.0 | 53.0 | 26.5 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3631 | 1143 | 1143.0 | 31.9 | 31.9 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 3632 | 1143 | 1143.0 | 29.3 | 29.3 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | False |
| 3633 | 3427 | 1142.3 | 111.0 | 37.0 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 3634 | 3424 | 1141.3 | 87.9 | 29.3 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3635 | 1141 | 1141.0 | 33.9 | 33.9 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3636 | 2282 | 1141.0 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H USSING, K ZERAHN | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3637 | 1141 | 1141.0 | 30.4 | 30.4 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3638 | 1141 | 1141.0 | 34.2 | 34.2 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | False |
| 3639 | 1141 | 1141.0 | 35.1 | 35.1 | The Danish Cancer Registry. | Marianne Lundkjær Gjerstorff | Scand J Public Health | 2011 | 21775350 | Yes |
| 3640 | 2281 | 1140.5 | 49.7 | 24.9 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | False |
| 3641 | 2281 | 1140.5 | 61.6 | 30.8 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3642 | 2281 | 1140.5 | 80.1 | 40.0 | ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. | Tauno Metsalu, Jaak Vilo | Nucleic Acids Res | 2015 | 25969447 | Yes |
| 3643 | 2281 | 1140.5 | 86.1 | 43.0 | OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. | David M Emms, Steven Kelly | Genome Biol | 2015 | 26243257 | Yes |
| 3644 | 1140 | 1140.0 | 17.4 | 17.4 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O EGEBERG | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3645 | 1140 | 1140.0 | 67.9 | 67.9 | Diffusion-in-gel methods for immunological analysis. II. | O OUCHTERLONY | Prog Allergy | 1962 | 14482809 | Yes |
| 3646 | 1140 | 1140.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D HOTCHKISS | Arch Biochem | 1948 | 18921848 | Yes |
| 3647 | 2280 | 1140.0 | 58.2 | 29.1 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | False |
| 3648 | 2279 | 1139.5 | 56.1 | 28.1 | Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. | Sophia Y Lunt, Matthew G Vander Heiden | Annu Rev Cell Dev Biol | 2011 | 21985671 | False |
| 3649 | 1139 | 1139.0 | 19.1 | 19.1 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3650 | 4556 | 1139.0 | 145.6 | 36.4 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | False |
| 3651 | 1139 | 1139.0 | 28.5 | 28.5 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | False |
| 3652 | 1139 | 1139.0 | 24.5 | 24.5 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | False |
| 3653 | 2278 | 1139.0 | 58.8 | 29.4 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | False |
| 3654 | 3415 | 1138.3 | 90.8 | 30.3 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3655 | 1138 | 1138.0 | 32.0 | 32.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3656 | 2276 | 1138.0 | 59.1 | 29.6 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | False |
| 3657 | 2276 | 1138.0 | 45.0 | 22.5 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | False |
| 3658 | 1138 | 1138.0 | 20.3 | 20.3 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3659 | 1138 | 1138.0 | 22.7 | 22.7 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | False |
| 3660 | 1138 | 1138.0 | 16.7 | 16.7 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J PENNINGTON | Biochem J | 1961 | 13734134 | Yes |
| 3661 | 1138 | 1138.0 | 29.3 | 29.3 | The complex world of WNT receptor signalling. | Christof Niehrs | Nat Rev Mol Cell Biol | 2012 | 23151663 | False |
| 3662 | 2276 | 1138.0 | 71.7 | 35.9 | Infernal 1.1: 100-fold faster RNA homology searches. | Eric P Nawrocki, Sean R Eddy | Bioinformatics | 2013 | 24008419 | Yes |
| 3663 | 2275 | 1137.5 | 56.2 | 28.1 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | False |
| 3664 | 1137 | 1137.0 | 26.0 | 26.0 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3665 | 4548 | 1137.0 | 45.1 | 11.3 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLME | Lancet | 1963 | 13990765 | Yes |
| 3666 | 1137 | 1137.0 | 30.2 | 30.2 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | False |
| 3667 | 1137 | 1137.0 | 21.8 | 21.8 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3668 | 1137 | 1137.0 | 57.0 | 57.0 | Resin composite--state of the art. | Jack L Ferracane | Dent Mater | 2011 | 21093034 | False |
| 3669 | 3409 | 1136.3 | 103.7 | 34.6 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. | Irith Wiegand, Kai Hilpert, Robert E W Hancock | Nat Protoc | 2008 | 18274517 | Yes |
| 3670 | 2272 | 1136.0 | 45.1 | 22.6 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | False |
| 3671 | 2271 | 1135.5 | 59.3 | 29.6 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J Biol Chem | 1986 | 3456347 | Yes |
| 3672 | 1135 | 1135.0 | 40.9 | 40.9 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3673 | 1135 | 1135.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O SCHILD | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 3674 | 5675 | 1135.0 | 232.1 | 46.4 | KEGG: new perspectives on genomes, pathways, diseases and drugs. | Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima | Nucleic Acids Res | 2017 | 27899662 | Yes |
| 3675 | 3404 | 1134.7 | 100.4 | 33.5 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3676 | 2269 | 1134.5 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C TRUELOVE, L J WITTS | Br Med J | 1955 | 13260656 | Yes |
| 3677 | 6805 | 1134.2 | 172.7 | 28.8 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3678 | 1134 | 1134.0 | 20.4 | 20.4 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 3679 | 1134 | 1134.0 | 40.1 | 40.1 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | False |
| 3680 | 1134 | 1134.0 | 25.9 | 25.9 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 3681 | 1134 | 1134.0 | 24.1 | 24.1 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | False |
| 3682 | 3400 | 1133.3 | 93.1 | 31.0 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 3683 | 4533 | 1133.2 | 103.9 | 26.0 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 3684 | 1133 | 1133.0 | 34.7 | 34.7 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 3685 | 1133 | 1133.0 | 23.7 | 23.7 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | False |
| 3686 | 2266 | 1133.0 | 62.7 | 31.4 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H. Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3687 | 1133 | 1133.0 | 34.8 | 34.8 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | False |
| 3688 | 2265 | 1132.5 | 55.1 | 27.6 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3689 | 1132 | 1132.0 | 69.6 | 69.6 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 3690 | 2264 | 1132.0 | 72.2 | 36.1 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3691 | 1132 | 1132.0 | 40.4 | 40.4 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3692 | 1132 | 1132.0 | 25.0 | 25.0 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 3693 | 1132 | 1132.0 | 37.6 | 37.6 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | False |
| 3694 | 1132 | 1132.0 | 38.2 | 38.2 | Constructive and unconstructive repetitive thought. | Edward R Watkins | Psychol Bull | 2008 | 18298268 | False |
| 3695 | 1132 | 1132.0 | 38.4 | 38.4 | The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. | Peter C Austin | Stat Med | 2014 | 24122911 | Yes |
| 3696 | 2263 | 1131.5 | 88.5 | 44.2 | The Human Intestinal Microbiome in Health and Disease. | Susan V Lynch, Oluf Pedersen | N Engl J Med | 2016 | 27974040 | False |
| 3697 | 1131 | 1131.0 | 56.7 | 56.7 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3698 | 1131 | 1131.0 | 27.5 | 27.5 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | False |
| 3699 | 2262 | 1131.0 | 40.9 | 20.4 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | False |
| 3700 | 1131 | 1131.0 | 21.0 | 21.0 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | False |
| 3701 | 1131 | 1131.0 | 28.9 | 28.9 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | False |
| 3702 | 1131 | 1131.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3703 | 3393 | 1131.0 | 98.4 | 32.8 | Macrophage biology in development, homeostasis and disease. | Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard | Nature | 2013 | 23619691 | False |
| 3704 | 1130 | 1130.0 | 23.6 | 23.6 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | False |
| 3705 | 1130 | 1130.0 | 42.6 | 42.6 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | False |
| 3706 | 1130 | 1130.0 | 28.7 | 28.7 | Gibberellin metabolism and its regulation. | Shinjiro Yamaguchi | Annu Rev Plant Biol | 2008 | 18173378 | False |
| 3707 | 1130 | 1130.0 | 42.9 | 42.9 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | False |
| 3708 | 1129 | 1129.0 | 39.9 | 39.9 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | False |
| 3709 | 1129 | 1129.0 | 28.5 | 28.5 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 3710 | 1129 | 1129.0 | 43.8 | 43.8 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3711 | 2258 | 1129.0 | 63.0 | 31.5 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3712 | 2258 | 1129.0 | 49.5 | 24.8 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3713 | 1129 | 1129.0 | 33.0 | 33.0 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | False |
| 3714 | 1129 | 1129.0 | 31.6 | 31.6 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | False |
| 3715 | 2256 | 1128.0 | 45.2 | 22.6 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 3716 | 1128 | 1128.0 | 44.3 | 44.3 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3717 | 1128 | 1128.0 | 26.7 | 26.7 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3718 | 1128 | 1128.0 | 25.9 | 25.9 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3719 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B STAVITSKY | J Immunol | 1954 | 13163409 | Yes |
| 3720 | 1128 | 1128.0 | 31.8 | 31.8 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. | Masabumi Shibuya | Genes Cancer | 2011 | 22866201 | Yes |
| 3721 | 2256 | 1128.0 | 91.1 | 45.5 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jérôme Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | False |
| 3722 | 2255 | 1127.5 | 36.4 | 18.2 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 3723 | 2255 | 1127.5 | 56.5 | 28.2 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nuñez | Nat Rev Immunol | 2010 | 21088683 | False |
| 3724 | 1127 | 1127.0 | 81.4 | 81.4 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3725 | 2254 | 1127.0 | 55.5 | 27.8 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 3726 | 1127 | 1127.0 | 33.2 | 33.2 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 3727 | 1127 | 1127.0 | 31.6 | 31.6 | Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. | J C Morris | Int Psychogeriatr | 1997 | 9447441 | Yes |
| 3728 | 1127 | 1127.0 | 33.2 | 33.2 | The mental health continuum: from languishing to flourishing in life. | Corey L M Keyes | J Health Soc Behav | 2002 | 12096700 | Yes |
| 3729 | 1127 | 1127.0 | 38.5 | 38.5 | The pain self-efficacy questionnaire: Taking pain into account. | Michael K Nicholas | Eur J Pain | 2007 | 16446108 | Yes |
| 3730 | 1127 | 1127.0 | 22.8 | 22.8 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | False |
| 3731 | 2254 | 1127.0 | 95.8 | 47.9 | Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. | Douglas J Morrison, Tom Preston | Gut Microbes | 2016 | 26963409 | False |
| 3732 | 3379 | 1126.3 | 97.0 | 32.3 | AMPK: a nutrient and energy sensor that maintains energy homeostasis. | D Grahame Hardie, Fiona A Ross, Simon A Hawley | Nat Rev Mol Cell Biol | 2012 | 22436748 | False |
| 3733 | 2252 | 1126.0 | 53.3 | 26.6 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3734 | 1126 | 1126.0 | 28.6 | 28.6 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 3735 | 2252 | 1126.0 | 84.5 | 42.2 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3736 | 1126 | 1126.0 | 20.1 | 20.1 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3737 | 1126 | 1126.0 | 21.8 | 21.8 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | False |
| 3738 | 2252 | 1126.0 | 58.4 | 29.2 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | False |
| 3739 | 6753 | 1125.5 | 184.9 | 30.8 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3740 | 1125 | 1125.0 | 49.6 | 49.6 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | False |
| 3741 | 1125 | 1125.0 | 34.0 | 34.0 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | False |
| 3742 | 1125 | 1125.0 | 34.4 | 34.4 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | False |
| 3743 | 1125 | 1125.0 | 28.0 | 28.0 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | False |
| 3744 | 1125 | 1125.0 | 26.8 | 26.8 | Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. | R Zahorec | Bratisl Lek Listy | 2001 | 11723675 | Yes |
| 3745 | 1125 | 1125.0 | 26.6 | 26.6 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | False |
| 3746 | 1125 | 1125.0 | 29.3 | 29.3 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | False |
| 3747 | 1125 | 1125.0 | 31.4 | 31.4 | Normal bone anatomy and physiology. | Bart Clarke | Clin J Am Soc Nephrol | 2008 | 18988698 | False |
| 3748 | 3374 | 1124.7 | 168.7 | 56.2 | Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. | Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas | Nurs Health Sci | 2013 | 23480423 | False |
| 3749 | 2249 | 1124.5 | 87.7 | 43.9 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3750 | 1124 | 1124.0 | 26.7 | 26.7 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | False |
| 3751 | 1124 | 1124.0 | 43.0 | 43.0 | A polarizing question: do M1 and M2 microglia exist? | Richard M Ransohoff | Nat Neurosci | 2016 | 27459405 | False |
| 3752 | 1123 | 1123.0 | 41.4 | 41.4 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 3753 | 2246 | 1123.0 | 48.7 | 24.4 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 3754 | 1123 | 1123.0 | 27.1 | 27.1 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | False |
| 3755 | 1123 | 1123.0 | 25.7 | 25.7 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3756 | 2246 | 1123.0 | 45.3 | 22.6 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | False |
| 3757 | 1123 | 1123.0 | 38.5 | 38.5 | Considerations in determining sample size for pilot studies. | Melody A Hertzog | Res Nurs Health | 2008 | 18183564 | False |
| 3758 | 3368 | 1122.7 | 76.0 | 25.3 | STATs in cancer inflammation and immunity: a leading role for STAT3. | Hua Yu, Drew Pardoll, Richard Jove | Nat Rev Cancer | 2009 | 19851315 | False |
| 3759 | 2245 | 1122.5 | 135.4 | 67.7 | Modified reagents for determination of urea and ammonia. | A L CHANEY, E P MARBACH | Clin Chem | 1962 | 13878063 | Yes |
| 3760 | 2244 | 1122.0 | 84.2 | 42.1 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3761 | 1122 | 1122.0 | 18.5 | 18.5 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3762 | 1122 | 1122.0 | 32.7 | 32.7 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | False |
| 3763 | 1122 | 1122.0 | 25.9 | 25.9 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3764 | 1122 | 1122.0 | 24.2 | 24.2 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | False |
| 3765 | 1122 | 1122.0 | 44.4 | 44.4 | Vitamin D metabolism, mechanism of action, and clinical applications. | Daniel D Bikle | Chem Biol | 2014 | 24529992 | False |
| 3766 | 2243 | 1121.5 | 40.8 | 20.4 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3767 | 2242 | 1121.0 | 89.8 | 44.9 | The aggression questionnaire. | A H Buss, M Perry | J Pers Soc Psychol | 1992 | 1403624 | Yes |
| 3768 | 1121 | 1121.0 | 29.7 | 29.7 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 3769 | 1121 | 1121.0 | 27.8 | 27.8 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | False |
| 3770 | 1121 | 1121.0 | 36.0 | 36.0 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
| 3771 | 1121 | 1121.0 | 29.4 | 29.4 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | False |
| 3772 | 1121 | 1121.0 | 31.6 | 31.6 | Cellular and molecular mechanisms of renal fibrosis. | Youhua Liu | Nat Rev Nephrol | 2011 | 22009250 | False |
| 3773 | 1121 | 1121.0 | 43.4 | 43.4 | Reference methods for the assessment of physical characteristics of meat. | K O Honikel | Meat Sci | 1998 | 22060626 | Yes |
| 3774 | 1121 | 1121.0 | 41.0 | 41.0 | Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. | Georgia Salanti | Res Synth Methods | 2012 | 26062083 | Yes |
| 3775 | 2241 | 1120.5 | 99.5 | 49.8 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3776 | 1120 | 1120.0 | 23.2 | 23.2 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 3777 | 1120 | 1120.0 | 20.4 | 20.4 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | False |
| 3778 | 1120 | 1120.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W WHITE | Psychol Rev | 1959 | 13844397 | Yes |
| 3779 | 3360 | 1120.0 | 67.0 | 22.3 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. | Juri Rappsilber, Matthias Mann, Yasushi Ishihama | Nat Protoc | 2007 | 17703201 | Yes |
| 3780 | 2240 | 1120.0 | 47.1 | 23.6 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. | Javier A Menendez, Ruth Lupu | Nat Rev Cancer | 2007 | 17882277 | False |
| 3781 | 1120 | 1120.0 | 44.2 | 44.2 | Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). | Laura J Julian | Arthritis Care Res (Hoboken) | 2011 | 22588767 | False |
| 3782 | 1119 | 1119.0 | 25.0 | 25.0 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3783 | 3357 | 1119.0 | 64.1 | 21.4 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3784 | 1119 | 1119.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L LEKSELL | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3785 | 1119 | 1119.0 | 0.0 | 0.0 | A new microscopic principle. | D GABOR | Nature | 1948 | 18860291 | Yes |
| 3786 | 2238 | 1119.0 | 63.2 | 31.6 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 3787 | 1119 | 1119.0 | 33.0 | 33.0 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | False |
| 3788 | 2237 | 1118.5 | 64.6 | 32.3 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | False |
| 3789 | 1118 | 1118.0 | 37.2 | 37.2 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | False |
| 3790 | 1118 | 1118.0 | 26.4 | 26.4 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | False |
| 3791 | 1118 | 1118.0 | 24.5 | 24.5 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | False |
| 3792 | 2236 | 1118.0 | 55.1 | 27.6 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | Laetitia Prut, Catherine Belzung | Eur J Pharmacol | 2003 | 12600700 | False |
| 3793 | 1118 | 1118.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B REXED | J Comp Neurol | 1954 | 13163236 | Yes |
| 3794 | 1118 | 1118.0 | 26.4 | 26.4 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | False |
| 3795 | 2236 | 1118.0 | 55.4 | 27.7 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | False |
| 3796 | 1118 | 1118.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
| 3797 | 1118 | 1118.0 | 44.0 | 44.0 | Root canal irrigants. | Matthias Zehnder | J Endod | 2006 | 16631834 | False |
| 3798 | 2235 | 1117.5 | 71.1 | 35.5 | Positive psychology. An introduction. | M E Seligman, M Csikszentmihalyi | Am Psychol | 2000 | 11392865 | Yes |
| 3799 | 4470 | 1117.5 | 115.7 | 28.9 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 3800 | 3352 | 1117.3 | 119.1 | 39.7 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 3801 | 2234 | 1117.0 | 70.5 | 35.2 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | False |
| 3802 | 1117 | 1117.0 | 32.8 | 32.8 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | False |
| 3803 | 1117 | 1117.0 | 41.1 | 41.1 | View through a window may influence recovery from surgery. | R S Ulrich | Science | 1984 | 6143402 | Yes |
| 3804 | 7817 | 1116.7 | 134.3 | 19.2 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3805 | 3349 | 1116.3 | 173.5 | 57.8 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | False |
| 3806 | 1116 | 1116.0 | 31.1 | 31.1 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | False |
| 3807 | 1116 | 1116.0 | 23.8 | 23.8 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | False |
| 3808 | 1116 | 1116.0 | 28.8 | 28.8 | Electrogenerated chemiluminescence and its biorelated applications. | Wujian Miao | Chem Rev | 2008 | 18505298 | False |
| 3809 | 2232 | 1116.0 | 56.1 | 28.1 | Monocyte recruitment during infection and inflammation. | Chao Shi, Eric G Pamer | Nat Rev Immunol | 2011 | 21984070 | False |
| 3810 | 2232 | 1116.0 | 87.7 | 43.9 | Shared decision making--pinnacle of patient-centered care. | Michael J Barry, Susan Edgman-Levitan | N Engl J Med | 2012 | 22375967 | Yes |
| 3811 | 1116 | 1116.0 | 54.3 | 54.3 | A decade of immune-checkpoint inhibitors in cancer therapy. | Caroline Robert | Nat Commun | 2020 | 32732879 | Yes |
| 3812 | 4463 | 1115.8 | 170.5 | 42.6 | The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. | L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg | Arch Neurol | 1989 | 2803071 | Yes |
| 3813 | 5577 | 1115.4 | 198.8 | 39.8 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3814 | 2230 | 1115.0 | 53.9 | 26.9 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 3815 | 1115 | 1115.0 | 13.3 | 13.3 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 3816 | 2229 | 1114.5 | 86.6 | 43.3 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3817 | 2229 | 1114.5 | 57.8 | 28.9 | Cu-catalyzed azide-alkyne cycloaddition. | Morten Meldal, Christian Wenzel Tornøe | Chem Rev | 2008 | 18698735 | False |
| 3818 | 3343 | 1114.3 | 79.7 | 26.6 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | False |
| 3819 | 1114 | 1114.0 | 27.1 | 27.1 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | False |
| 3820 | 1114 | 1114.0 | 21.2 | 21.2 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | False |
| 3821 | 1114 | 1114.0 | 22.4 | 22.4 | Alpha-synuclein and neurodegenerative diseases. | M Goedert | Nat Rev Neurosci | 2001 | 11433374 | False |
| 3822 | 2228 | 1114.0 | 32.4 | 16.2 | Microdroplet Assay Of Human Serum Cytotoxins. | P I TERASAKI, J D MCCLELLAND | Nature | 1964 | 14248725 | Yes |
| 3823 | 1114 | 1114.0 | 31.5 | 31.5 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | False |
| 3824 | 1114 | 1114.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 3825 | 1114 | 1114.0 | 31.1 | 31.1 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | False |
| 3826 | 1113 | 1113.0 | 28.0 | 28.0 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | False |
| 3827 | 1113 | 1113.0 | 36.5 | 36.5 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3828 | 20021 | 1112.3 | 482.1 | 26.8 | PHENIX: a comprehensive Python-based system for macromolecular structure solution. | Paul D Adams, Pavel V Afonine, Gábor Bunkóczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart | Acta Crystallogr D Biol Crystallogr | 2010 | 20124702 | Yes |
| 3829 | 4449 | 1112.2 | 199.6 | 49.9 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | False |
| 3830 | 1112 | 1112.0 | 30.5 | 30.5 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | False |
| 3831 | 1112 | 1112.0 | 26.3 | 26.3 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3832 | 1112 | 1112.0 | 23.0 | 23.0 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 3833 | 2224 | 1112.0 | 50.2 | 25.1 | Efficient behavior of small-world networks. | V Latora, M Marchiori | Phys Rev Lett | 2001 | 11690461 | Yes |
| 3834 | 1112 | 1112.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A EASTERBROOK | Psychol Rev | 1959 | 13658305 | Yes |
| 3835 | 4448 | 1112.0 | 141.9 | 35.5 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 3836 | 1112 | 1112.0 | 42.1 | 42.1 | Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. | Walter S Leal | Annu Rev Entomol | 2013 | 23020622 | False |
| 3837 | 5558 | 1111.6 | 149.1 | 29.8 | A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi | Cell | 2011 | 21802130 | Yes |
| 3838 | 2222 | 1111.0 | 65.8 | 32.9 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 3839 | 1111 | 1111.0 | 23.9 | 23.9 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | False |
| 3840 | 1111 | 1111.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J DEESE | J Exp Psychol | 1959 | 13664879 | Yes |
| 3841 | 2222 | 1111.0 | 27.0 | 13.5 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P GOLD, S O FREEDMAN | J Exp Med | 1965 | 14270243 | Yes |
| 3842 | 17776 | 1111.0 | 664.0 | 41.5 | SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. | Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner | J Comput Biol | 2012 | 22506599 | Yes |
| 3843 | 2221 | 1110.5 | 69.7 | 34.9 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | False |
| 3844 | 1110 | 1110.0 | 23.2 | 23.2 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 3845 | 1110 | 1110.0 | 36.8 | 36.8 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | False |
| 3846 | 1110 | 1110.0 | 26.6 | 26.6 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | False |
| 3847 | 3329 | 1109.7 | 220.5 | 73.5 | How to perform a meta-analysis with R: a practical tutorial. | Sara Balduzzi, Gerta Rücker, Guido Schwarzer | Evid Based Ment Health | 2019 | 31563865 | Yes |
| 3848 | 1109 | 1109.0 | 25.9 | 25.9 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 3849 | 1109 | 1109.0 | 28.1 | 28.1 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | False |
| 3850 | 1109 | 1109.0 | 18.5 | 18.5 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | False |
| 3851 | 3327 | 1109.0 | 72.0 | 24.0 | Mitochondria, oxidants, and aging. | Robert S Balaban, Shino Nemoto, Toren Finkel | Cell | 2005 | 15734681 | False |
| 3852 | 1109 | 1109.0 | 20.6 | 20.6 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | False |
| 3853 | 2217 | 1108.5 | 76.2 | 38.1 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
| 3854 | 3325 | 1108.3 | 110.4 | 36.8 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 3855 | 1108 | 1108.0 | 25.6 | 25.6 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | False |
| 3856 | 1108 | 1108.0 | 25.2 | 25.2 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | False |
| 3857 | 1108 | 1108.0 | 33.4 | 33.4 | Recommended effect size statistics for repeated measures designs. | Roger Bakeman | Behav Res Methods | 2005 | 16405133 | Yes |
| 3858 | 2215 | 1107.5 | 65.0 | 32.5 | Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. | R J Ginsberg, L V Rubinstein | Ann Thorac Surg | 1995 | 7677489 | Yes |
| 3859 | 1107 | 1107.0 | 22.1 | 22.1 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | False |
| 3860 | 1107 | 1107.0 | 21.7 | 21.7 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | False |
| 3861 | 1107 | 1107.0 | 33.9 | 33.9 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | False |
| 3862 | 2213 | 1106.5 | 94.5 | 47.2 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 3863 | 1106 | 1106.0 | 36.1 | 36.1 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 3864 | 1106 | 1106.0 | 26.7 | 26.7 | Omega-3 fatty acids in inflammation and autoimmune diseases. | Artemis P Simopoulos | J Am Coll Nutr | 2002 | 12480795 | False |
| 3865 | 1106 | 1106.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W TEALE | Biochim Biophys Acta | 1959 | 13837237 | Yes |
| 3866 | 1106 | 1106.0 | 30.0 | 30.0 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | False |
| 3867 | 1106 | 1106.0 | 41.0 | 41.0 | Surface-enhanced Raman spectroscopy: concepts and chemical applications. | Sebastian Schlücker | Angew Chem Int Ed Engl | 2014 | 24711218 | Yes |
| 3868 | 4421 | 1105.2 | 95.8 | 23.9 | Isolation and characterization of exosomes from cell culture supernatants and biological fluids. | Clotilde Théry, Sebastian Amigorena, Graça Raposo, Aled Clayton | Curr Protoc Cell Biol | 2006 | 18228490 | Yes |
| 3869 | 1105 | 1105.0 | 54.9 | 54.9 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | False |
| 3870 | 1105 | 1105.0 | 26.9 | 26.9 | Biological effects of resveratrol. | L Frémont | Life Sci | 2000 | 10680575 | False |
| 3871 | 2210 | 1105.0 | 46.5 | 23.2 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 3872 | 1105 | 1105.0 | 24.6 | 24.6 | What is principal component analysis? | Markus Ringnér | Nat Biotechnol | 2008 | 18327243 | Yes |
| 3873 | 2209 | 1104.5 | 45.7 | 22.9 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | False |
| 3874 | 4417 | 1104.2 | 83.8 | 20.9 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3875 | 1104 | 1104.0 | 59.8 | 59.8 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | False |
| 3876 | 2208 | 1104.0 | 77.4 | 38.7 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | False |
| 3877 | 1104 | 1104.0 | 22.4 | 22.4 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | False |
| 3878 | 1104 | 1104.0 | 32.0 | 32.0 | Targeting the DNA Damage Response in Cancer. | Mark J O'Connor | Mol Cell | 2015 | 26590714 | False |
| 3879 | 2208 | 1104.0 | 82.6 | 41.3 | Gut microbiota, metabolites and host immunity. | Michelle G Rooks, Wendy S Garrett | Nat Rev Immunol | 2016 | 27231050 | False |
| 3880 | 4415 | 1103.8 | 102.5 | 25.6 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 3881 | 2207 | 1103.5 | 48.8 | 24.4 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | False |
| 3882 | 2207 | 1103.5 | 51.6 | 25.8 | A note on quantifying follow-up in studies of failure time. | M Schemper, T L Smith | Control Clin Trials | 1996 | 8889347 | Yes |
| 3883 | 2207 | 1103.5 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H COONS, M H KAPLAN | J Exp Med | 1950 | 15395569 | Yes |
| 3884 | 2207 | 1103.5 | 83.1 | 41.5 | Epidemiology of adult fractures: A review. | Charles M Court-Brown, Ben Caesar | Injury | 2006 | 16814787 | False |
| 3885 | 2206 | 1103.0 | 43.9 | 21.9 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Kärre | Immunol Today | 1990 | 2201309 | False |
| 3886 | 1103 | 1103.0 | 35.5 | 35.5 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 3887 | 1103 | 1103.0 | 21.7 | 21.7 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | False |
| 3888 | 1103 | 1103.0 | 38.1 | 38.1 | Development of the practice environment scale of the Nursing Work Index. | Eileen T Lake | Res Nurs Health | 2002 | 12015780 | Yes |
| 3889 | 1103 | 1103.0 | 37.0 | 37.0 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | False |
| 3890 | 2206 | 1103.0 | 84.7 | 42.4 | Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). | Marta Kutas, Kara D Federmeier | Annu Rev Psychol | 2011 | 20809790 | False |
| 3891 | 2205 | 1102.5 | 53.8 | 26.9 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | False |
| 3892 | 2204 | 1102.0 | 49.6 | 24.8 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | False |
| 3893 | 1102 | 1102.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H KASS | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 3894 | 1102 | 1102.0 | 23.4 | 23.4 | Pyramidal neurons: dendritic structure and synaptic integration. | Nelson Spruston | Nat Rev Neurosci | 2008 | 18270515 | False |
| 3895 | 1102 | 1102.0 | 35.5 | 35.5 | Biomedical photoacoustic imaging. | Paul Beard | Interface Focus | 2011 | 22866233 | Yes |
| 3896 | 2202 | 1101.0 | 107.8 | 53.9 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 3897 | 1101 | 1101.0 | 39.9 | 39.9 | An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. | F G Happé | J Autism Dev Disord | 1994 | 8040158 | Yes |
| 3898 | 1101 | 1101.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W SPERRY | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 3899 | 5504 | 1100.8 | 114.9 | 23.0 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
| 3900 | 4401 | 1100.2 | 158.9 | 39.7 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 3901 | 1100 | 1100.0 | 21.9 | 21.9 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 3902 | 2200 | 1100.0 | 45.4 | 22.7 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | False |
| 3903 | 1100 | 1100.0 | 31.4 | 31.4 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | False |
| 3904 | 1100 | 1100.0 | 29.2 | 29.2 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 3905 | 1100 | 1100.0 | 18.8 | 18.8 | 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. | Judith K Christman | Oncogene | 2002 | 12154409 | False |
| 3906 | 1099 | 1099.0 | 11.3 | 11.3 | Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. | J J Hopfield | Proc Natl Acad Sci U S A | 1974 | 4530290 | Yes |
| 3907 | 1099 | 1099.0 | 41.9 | 41.9 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | False |
| 3908 | 2198 | 1099.0 | 65.3 | 32.6 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | False |
| 3909 | 2198 | 1099.0 | 63.4 | 31.7 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | False |
| 3910 | 1099 | 1099.0 | 33.8 | 33.8 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | False |
| 3911 | 1099 | 1099.0 | 24.2 | 24.2 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | False |
| 3912 | 2198 | 1099.0 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E VAN HANDEL, D B ZILVERSMIT | J Lab Clin Med | 1957 | 13439279 | Yes |
| 3913 | 1099 | 1099.0 | 24.4 | 24.4 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | False |
| 3914 | 1099 | 1099.0 | 31.5 | 31.5 | The social brain in adolescence. | Sarah-Jayne Blakemore | Nat Rev Neurosci | 2008 | 18354399 | False |
| 3915 | 3296 | 1098.7 | 133.6 | 44.5 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 3916 | 2197 | 1098.5 | 95.5 | 47.8 | The Tumor Microenvironment Innately Modulates Cancer Progression. | Dominique C Hinshaw, Lalita A Shevde | Cancer Res | 2019 | 31350295 | False |
| 3917 | 4393 | 1098.2 | 107.8 | 26.9 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 3918 | 1098 | 1098.0 | 27.3 | 27.3 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
| 3919 | 1098 | 1098.0 | 20.6 | 20.6 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
| 3920 | 1098 | 1098.0 | 18.9 | 18.9 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | False |
| 3921 | 1098 | 1098.0 | 29.8 | 29.8 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | False |
| 3922 | 1098 | 1098.0 | 36.7 | 36.7 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
| 3923 | 1098 | 1098.0 | 22.3 | 22.3 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | False |
| 3924 | 1098 | 1098.0 | 26.5 | 26.5 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | False |
| 3925 | 2196 | 1098.0 | 46.4 | 23.2 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | False |
| 3926 | 1097 | 1097.0 | 23.9 | 23.9 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | False |
| 3927 | 2193 | 1096.5 | 53.1 | 26.6 | The neural basis of decision making. | Joshua I Gold, Michael N Shadlen | Annu Rev Neurosci | 2007 | 17600525 | False |
| 3928 | 1096 | 1096.0 | 20.6 | 20.6 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
| 3929 | 2192 | 1096.0 | 51.3 | 25.6 | The oxytocin receptor system: structure, function, and regulation. | G Gimpl, F Fahrenholz | Physiol Rev | 2001 | 11274341 | False |
| 3930 | 4382 | 1095.5 | 112.3 | 28.1 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 3931 | 2190 | 1095.0 | 64.3 | 32.1 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 3932 | 5475 | 1095.0 | 254.6 | 50.9 | VSEARCH: a versatile open source tool for metagenomics. | Torbjørn Rognes, Tomáš Flouri, Ben Nichols, Christopher Quince, Frédéric Mahé | PeerJ | 2016 | 27781170 | Yes |
| 3933 | 2189 | 1094.5 | 34.7 | 17.4 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | False |
| 3934 | 5472 | 1094.4 | 175.4 | 35.1 | A simulation study of the number of events per variable in logistic regression analysis. | P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein | J Clin Epidemiol | 1996 | 8970487 | Yes |
| 3935 | 2188 | 1094.0 | 70.9 | 35.5 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 3936 | 3282 | 1094.0 | 109.3 | 36.4 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 3937 | 1094 | 1094.0 | 21.4 | 21.4 | Automated NMR structure calculation with CYANA. | Peter Güntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 3938 | 1094 | 1094.0 | 24.8 | 24.8 | Mucins in cancer: function, prognosis and therapy. | Donald W Kufe | Nat Rev Cancer | 2009 | 19935676 | False |
| 3939 | 2187 | 1093.5 | 38.1 | 19.1 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 3940 | 2187 | 1093.5 | 51.8 | 25.9 | Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Bioinformatics | 2007 | 17050570 | Yes |
| 3941 | 2187 | 1093.5 | 53.1 | 26.6 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | False |
| 3942 | 3280 | 1093.3 | 78.5 | 26.2 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. | Chun-Chi Liang, Ann Y Park, Jun-Lin Guan | Nat Protoc | 2007 | 17406593 | Yes |
| 3943 | 1093 | 1093.0 | 18.8 | 18.8 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
| 3944 | 1093 | 1093.0 | 22.4 | 22.4 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | False |
| 3945 | 1093 | 1093.0 | 0.0 | 0.0 | The purine and pyrimidine composition of deoxypentose nucleic acids. | G R WYATT | Biochem J | 1951 | 14838906 | Yes |
| 3946 | 1093 | 1093.0 | 26.8 | 26.8 | Telomere length measurement by a novel monochrome multiplex quantitative PCR method. | Richard M Cawthon | Nucleic Acids Res | 2009 | 19129229 | Yes |
| 3947 | 3279 | 1093.0 | 131.2 | 43.7 | The biology and management of non-small cell lung cancer. | Roy S Herbst, Daniel Morgensztern, Chris Boshoff | Nature | 2018 | 29364287 | False |
| 3948 | 6557 | 1092.8 | 164.0 | 27.3 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 3949 | 2185 | 1092.5 | 68.2 | 34.1 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | False |
| 3950 | 1092 | 1092.0 | 21.0 | 21.0 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat Rev Genet | 2007 | 17304246 | False |
| 3951 | 1092 | 1092.0 | 0.0 | 0.0 | Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. | S M PARTRIDGE | Nature | 1949 | 18140444 | Yes |
| 3952 | 1092 | 1092.0 | 47.4 | 47.4 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. | Daniel J Drucker | Cell Metab | 2018 | 29617641 | False |
| 3953 | 2183 | 1091.5 | 63.9 | 31.9 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | False |
| 3954 | 2183 | 1091.5 | 60.1 | 30.1 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N Engl J Med | 2007 | 17652652 | Yes |
| 3955 | 1091 | 1091.0 | 20.1 | 20.1 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | False |
| 3956 | 1091 | 1091.0 | 13.3 | 13.3 | The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. | C CRONE | Acta Physiol Scand | 1963 | 14078649 | Yes |
| 3957 | 1091 | 1091.0 | 25.4 | 25.4 | The emotional brain, fear, and the amygdala. | Joseph LeDoux | Cell Mol Neurobiol | 2003 | 14514027 | False |
| 3958 | 1091 | 1091.0 | 29.3 | 29.3 | Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. | John W Newcomer | CNS Drugs | 2005 | 15998156 | False |
| 3959 | 1091 | 1091.0 | 22.8 | 22.8 | The molecular biology of coronaviruses. | Paul S Masters | Adv Virus Res | 2006 | 16877062 | False |
| 3960 | 2182 | 1091.0 | 48.8 | 24.4 | How to interpret LC3 immunoblotting. | Noboru Mizushima, Tamotsu Yoshimori | Autophagy | 2007 | 17611390 | False |
| 3961 | 1091 | 1091.0 | 34.4 | 34.4 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 3962 | 1090 | 1090.0 | 18.9 | 18.9 | Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. | W Kolch | Biochem J | 2000 | 11023813 | False |
| 3963 | 1090 | 1090.0 | 32.0 | 32.0 | Spontaneous dissection of the carotid and vertebral arteries. | W I Schievink | N Engl J Med | 2001 | 11259724 | False |
| 3964 | 1090 | 1090.0 | 26.3 | 26.3 | Hybridization as an invasion of the genome. | James Mallet | Trends Ecol Evol | 2005 | 16701374 | Yes |
| 3965 | 1090 | 1090.0 | 23.3 | 23.3 | The action potential in mammalian central neurons. | Bruce P Bean | Nat Rev Neurosci | 2007 | 17514198 | False |
| 3966 | 1090 | 1090.0 | 56.2 | 56.2 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. | Héctor F Escobar-Morreale | Nat Rev Endocrinol | 2018 | 29569621 | False |
| 3967 | 7628 | 1089.7 | 549.9 | 78.6 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. | Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia | Mol Plant | 2020 | 32585190 | Yes |
| 3968 | 10892 | 1089.2 | 451.8 | 45.2 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. | David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison | Acta Neuropathol | 2016 | 27157931 | False |
| 3969 | 1089 | 1089.0 | 37.3 | 37.3 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann Surg | 1992 | 1503516 | False |
| 3970 | 1089 | 1089.0 | 32.3 | 32.3 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 3971 | 1089 | 1089.0 | 44.6 | 44.6 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | False |
| 3972 | 1089 | 1089.0 | 20.2 | 20.2 | Cytokines in cancer pathogenesis and cancer therapy. | Glenn Dranoff | Nat Rev Cancer | 2004 | 14708024 | False |
| 3973 | 1089 | 1089.0 | 29.4 | 29.4 | Innate immunity of fish (overview). | Bergljót Magnadóttir | Fish Shellfish Immunol | 2006 | 15950491 | False |
| 3974 | 4354 | 1088.5 | 147.4 | 36.9 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 3975 | 2177 | 1088.5 | 87.4 | 43.7 | Global estimates of visual impairment: 2010. | Donatella Pascolini, Silvio Paolo Mariotti | Br J Ophthalmol | 2012 | 22133988 | Yes |
| 3976 | 2177 | 1088.5 | 58.2 | 29.1 | DNA methylation: roles in mammalian development. | Zachary D Smith, Alexander Meissner | Nat Rev Genet | 2013 | 23400093 | False |
| 3977 | 1088 | 1088.0 | 22.7 | 22.7 | The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. | S Roseman | Chem Phys Lipids | 1970 | 5476326 | Yes |
| 3978 | 1088 | 1088.0 | 38.2 | 38.2 | Coronary physiology. | E O Feigl | Physiol Rev | 1983 | 6296890 | False |
| 3979 | 1088 | 1088.0 | 31.6 | 31.6 | Image matching as a diffusion process: an analogy with Maxwell's demons. | J P Thirion | Med Image Anal | 1998 | 9873902 | Yes |
| 3980 | 1088 | 1088.0 | 24.6 | 24.6 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | False |
| 3981 | 2176 | 1088.0 | 0.0 | 0.0 | A revision of the Schoenheimer-Sperry method for cholesterol determination. | W M SPERRY, M WEBB | J Biol Chem | 1950 | 14794694 | Yes |
| 3982 | 1088 | 1088.0 | 37.9 | 37.9 | Microbial life in the phyllosphere. | Julia A Vorholt | Nat Rev Microbiol | 2012 | 23154261 | False |
| 3983 | 2175 | 1087.5 | 60.4 | 30.2 | Flexible regression models with cubic splines. | S Durrleman, R Simon | Stat Med | 1989 | 2657958 | Yes |
| 3984 | 2175 | 1087.5 | 51.3 | 25.6 | Peroxidase-labeled antibody. A new method of conjugation. | P K Nakane, A Kawaoi | J Histochem Cytochem | 1974 | 4443551 | Yes |
| 3985 | 2175 | 1087.5 | 73.2 | 36.6 | Glycosylation in cancer: mechanisms and clinical implications. | Salomé S Pinho, Celso A Reis | Nat Rev Cancer | 2015 | 26289314 | False |
| 3986 | 1087 | 1087.0 | 22.8 | 22.8 | Ligand-targeted therapeutics in anticancer therapy. | Theresa M Allen | Nat Rev Cancer | 2002 | 12360278 | False |
| 3987 | 1087 | 1087.0 | 18.3 | 18.3 | The concept of synthetic lethality in the context of anticancer therapy. | William G Kaelin | Nat Rev Cancer | 2005 | 16110319 | False |
| 3988 | 1087 | 1087.0 | 34.8 | 34.8 | Vitamin D status: measurement, interpretation, and clinical application. | Michael F Holick | Ann Epidemiol | 2009 | 18329892 | False |
| 3989 | 1087 | 1087.0 | 23.8 | 23.8 | Cells of origin in cancer. | Jane E Visvader | Nature | 2011 | 21248838 | False |
| 3990 | 2173 | 1086.5 | 43.5 | 21.8 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
| 3991 | 2173 | 1086.5 | 53.2 | 26.6 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief Bioinform | 2008 | 18372315 | Yes |
| 3992 | 2172 | 1086.0 | 88.2 | 44.1 | Emotional processing of fear: exposure to corrective information. | E B Foa, M J Kozak | Psychol Bull | 1986 | 2871574 | Yes |
| 3993 | 1086 | 1086.0 | 44.6 | 44.6 | Corticosteroids and lymphoid cells. | H N Claman | N Engl J Med | 1972 | 5043524 | Yes |
| 3994 | 1085 | 1085.0 | 37.0 | 37.0 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 3995 | 1085 | 1085.0 | 22.6 | 22.6 | T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. | R H Schwartz | Annu Rev Immunol | 1985 | 2415139 | False |
| 3996 | 1085 | 1085.0 | 40.9 | 40.9 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | False |
| 3997 | 1085 | 1085.0 | 33.3 | 33.3 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | False |
| 3998 | 1085 | 1085.0 | 12.8 | 12.8 | Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. | R M BERNE | Am J Physiol | 1963 | 13971060 | Yes |
| 3999 | 1085 | 1085.0 | 30.9 | 30.9 | Lanthanide-based luminescent hybrid materials. | Koen Binnemans | Chem Rev | 2009 | 19650663 | Yes |
| 4000 | 1085 | 1085.0 | 29.6 | 29.6 | Voltage-gated calcium channels. | William A Catterall | Cold Spring Harb Perspect Biol | 2011 | 21746798 | False |
| 4001 | 7595 | 1085.0 | 722.1 | 103.2 | The psychological impact of quarantine and how to reduce it: rapid review of the evidence. | Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin | Lancet | 2020 | 32112714 | False |
| 4002 | 2169 | 1084.5 | 46.7 | 23.4 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | False |
| 4003 | 1084 | 1084.0 | 38.1 | 38.1 | Perceptual selectivity for color and form. | J Theeuwes | Percept Psychophys | 1992 | 1620571 | False |
| 4004 | 1084 | 1084.0 | 23.1 | 23.1 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
| 4005 | 1084 | 1084.0 | 25.0 | 25.0 | Biochemistry and genetics of von Willebrand factor. | J E Sadler | Annu Rev Biochem | 1998 | 9759493 | False |
| 4006 | 1084 | 1084.0 | 23.5 | 23.5 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat Rev Neurosci | 2000 | 11252767 | False |
| 4007 | 1084 | 1084.0 | 20.4 | 20.4 | The immune response of Drosophila. | Jules A Hoffmann | Nature | 2003 | 14603309 | False |
| 4008 | 1084 | 1084.0 | 25.3 | 25.3 | NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. | Weihai Ying | Antioxid Redox Signal | 2008 | 18020963 | False |
| 4009 | 1083 | 1083.0 | 13.5 | 13.5 | The evolutionary advantage of recombination. | J Felsenstein | Genetics | 1974 | 4448362 | Yes |
| 4010 | 1083 | 1083.0 | 29.4 | 29.4 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | False |
| 4011 | 4332 | 1083.0 | 110.7 | 27.7 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res | 1996 | 8908518 | Yes |
| 4012 | 1083 | 1083.0 | 24.8 | 24.8 | Marine viruses and their biogeochemical and ecological effects. | J A Fuhrman | Nature | 1999 | 10376593 | False |
| 4013 | 2166 | 1083.0 | 53.4 | 26.7 | Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. | D Rice, S Barone | Environ Health Perspect | 2000 | 10852851 | False |
| 4014 | 1083 | 1083.0 | 21.3 | 21.3 | Unfolding the role of protein misfolding in neurodegenerative diseases. | Claudio Soto | Nat Rev Neurosci | 2003 | 12511861 | False |
| 4015 | 1083 | 1083.0 | 0.0 | 0.0 | On the Absorption of Fluids from the Connective Tissue Spaces. | E H Starling | J Physiol | 1896 | 16992325 | Yes |
| 4016 | 3248 | 1082.7 | 112.3 | 37.4 | The weirdest people in the world? | Joseph Henrich, Steven J Heine, Ara Norenzayan | Behav Brain Sci | 2010 | 20550733 | Yes |
| 4017 | 2165 | 1082.5 | 55.4 | 27.7 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. | L Pellerin, P J Magistretti | Proc Natl Acad Sci U S A | 1994 | 7938003 | Yes |
| 4018 | 2165 | 1082.5 | 77.6 | 38.8 | Coronaviruses: an overview of their replication and pathogenesis. | Anthony R Fehr, Stanley Perlman | Methods Mol Biol | 2015 | 25720466 | False |
| 4019 | 2163 | 1081.5 | 48.9 | 24.4 | Mechanisms of endocytosis. | Gary J Doherty, Harvey T McMahon | Annu Rev Biochem | 2009 | 19317650 | False |
| 4020 | 1081 | 1081.0 | 27.1 | 27.1 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | False |
| 4021 | 1081 | 1081.0 | 28.6 | 28.6 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 4022 | 1081 | 1081.0 | 18.4 | 18.4 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
| 4023 | 1081 | 1081.0 | 22.3 | 22.3 | Large-scale recording of neuronal ensembles. | György Buzsáki | Nat Neurosci | 2004 | 15114356 | False |
| 4024 | 1081 | 1081.0 | 23.8 | 23.8 | Immunosuppressive drugs for kidney transplantation. | Philip F Halloran | N Engl J Med | 2004 | 15616206 | False |
| 4025 | 2162 | 1081.0 | 78.3 | 39.1 | Perceived discrimination and health: a meta-analytic review. | Elizabeth A Pascoe, Laura Smart Richman | Psychol Bull | 2009 | 19586161 | Yes |
| 4026 | 4324 | 1081.0 | 112.1 | 28.0 | REVIGO summarizes and visualizes long lists of gene ontology terms. | Fran Supek, Matko Bošnjak, Nives Škunca, Tomislav Šmuc | PLoS One | 2011 | 21789182 | Yes |
| 4027 | 6484 | 1080.7 | 146.3 | 24.4 | Alpha-synuclein in Lewy bodies. | M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert | Nature | 1997 | 9278044 | Yes |
| 4028 | 2161 | 1080.5 | 45.0 | 22.5 | A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. | S Whelan, N Goldman | Mol Biol Evol | 2001 | 11319253 | Yes |
| 4029 | 2161 | 1080.5 | 51.9 | 25.9 | CpG islands and the regulation of transcription. | Aimée M Deaton, Adrian Bird | Genes Dev | 2011 | 21576262 | False |
| 4030 | 1080 | 1080.0 | 27.5 | 27.5 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
| 4031 | 1080 | 1080.0 | 29.0 | 29.0 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | False |
| 4032 | 1080 | 1080.0 | 23.4 | 23.4 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | False |
| 4033 | 1080 | 1080.0 | 29.5 | 29.5 | Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. | R Bonnet | Antimicrob Agents Chemother | 2004 | 14693512 | False |
| 4034 | 1080 | 1080.0 | 26.4 | 26.4 | Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. | Peter Fransson | Hum Brain Mapp | 2005 | 15852468 | Yes |
| 4035 | 1080 | 1080.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
| 4036 | 1080 | 1080.0 | 30.8 | 30.8 | Conceptual synthesis in community ecology. | Mark Vellend | Q Rev Biol | 2010 | 20565040 | False |
| 4037 | 6479 | 1079.8 | 137.6 | 22.9 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res | 1984 | 6091052 | Yes |
| 4038 | 1079 | 1079.0 | 32.2 | 32.2 | Topography of cognition: parallel distributed networks in primate association cortex. | P S Goldman-Rakic | Annu Rev Neurosci | 1988 | 3284439 | False |
| 4039 | 1079 | 1079.0 | 27.2 | 27.2 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
| 4040 | 2158 | 1079.0 | 44.4 | 22.2 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr Opin Cell Biol | 1997 | 9069255 | False |
| 4041 | 1079 | 1079.0 | 21.9 | 21.9 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | False |
| 4042 | 2158 | 1079.0 | 61.8 | 30.9 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | False |
| 4043 | 2157 | 1078.5 | 42.8 | 21.4 | Autophagy in health and disease: a double-edged sword. | Takahiro Shintani, Daniel J Klionsky | Science | 2004 | 15528435 | False |
| 4044 | 1078 | 1078.0 | 32.9 | 32.9 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
| 4045 | 1078 | 1078.0 | 42.2 | 42.2 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
| 4046 | 3234 | 1078.0 | 81.5 | 27.2 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
| 4047 | 1078 | 1078.0 | 30.5 | 30.5 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
| 4048 | 1078 | 1078.0 | 43.9 | 43.9 | Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. | Hannah R Snyder | Psychol Bull | 2013 | 22642228 | False |
| 4049 | 1078 | 1078.0 | 59.8 | 59.8 | Cisplatin: The first metal based anticancer drug. | Sumit Ghosh | Bioorg Chem | 2019 | 31003078 | False |
| 4050 | 2155 | 1077.5 | 101.7 | 50.9 | Development, reliability, and validity of a dissociation scale. | E M Bernstein, F W Putnam | J Nerv Ment Dis | 1986 | 3783140 | Yes |
| 4051 | 5387 | 1077.4 | 139.7 | 27.9 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4052 | 3232 | 1077.3 | 76.5 | 25.5 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | False |
| 4053 | 1077 | 1077.0 | 29.6 | 29.6 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
| 4054 | 2154 | 1077.0 | 80.2 | 40.1 | A psychomotor stimulant theory of addiction. | R A Wise, M A Bozarth | Psychol Rev | 1987 | 3317472 | False |
| 4055 | 2154 | 1077.0 | 44.6 | 22.3 | An energy budget for signaling in the grey matter of the brain. | D Attwell, S B Laughlin | J Cereb Blood Flow Metab | 2001 | 11598490 | False |
| 4056 | 1077 | 1077.0 | 31.3 | 31.3 | G(ST) and its relatives do not measure differentiation. | Lou Jost | Mol Ecol | 2008 | 19238703 | Yes |
| 4057 | 3230 | 1076.7 | 111.7 | 37.2 | The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. | Stefka Tyanova, Tikira Temu, Juergen Cox | Nat Protoc | 2016 | 27809316 | Yes |
| 4058 | 2153 | 1076.5 | 82.3 | 41.1 | Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. | G A Diamond, J S Forrester | N Engl J Med | 1979 | 440357 | Yes |
| 4059 | 1076 | 1076.0 | 23.2 | 23.2 | Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. | J Denis McGarry | Diabetes | 2002 | 11756317 | False |
| 4060 | 2151 | 1075.5 | 85.3 | 42.6 | Comparative aspects of the brain growth spurt. | J Dobbing, J Sands | Early Hum Dev | 1979 | 118862 | Yes |
| 4061 | 1075 | 1075.0 | 0.0 | 0.0 | The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. | M VOGT | J Physiol | 1954 | 13152692 | Yes |
| 4062 | 2150 | 1075.0 | 84.8 | 42.4 | Chronic catheterization of the spinal subarachnoid space. | T L Yaksh, T A Rudy | Physiol Behav | 1976 | 14677603 | Yes |
| 4063 | 2150 | 1075.0 | 53.3 | 26.6 | Mesenchymal stem cells as trophic mediators. | Arnold I Caplan, James E Dennis | J Cell Biochem | 2006 | 16619257 | False |
| 4064 | 1075 | 1075.0 | 54.4 | 54.4 | The expanding regulatory mechanisms and cellular functions of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2020 | 32366901 | False |
| 4065 | 2149 | 1074.5 | 48.2 | 24.1 | The significance of digital gene expression profiles. | S Audic, J M Claverie | Genome Res | 1997 | 9331369 | Yes |
| 4066 | 4298 | 1074.5 | 193.3 | 48.3 | Random effects structure for confirmatory hypothesis testing: Keep it maximal. | Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily | J Mem Lang | 2013 | 24403724 | Yes |
| 4067 | 1074 | 1074.0 | 14.1 | 14.1 | Relative and absolute strength of response as a function of frequency of reinforcement. | R J HERRNSTEIN | J Exp Anal Behav | 1961 | 13713775 | Yes |
| 4068 | 1074 | 1074.0 | 26.6 | 26.6 | Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. | Randy L Buckner | Neuron | 2004 | 15450170 | False |
| 4069 | 1074 | 1074.0 | 20.1 | 20.1 | Tetraspanin functions and associated microdomains. | Martin E Hemler | Nat Rev Mol Cell Biol | 2005 | 16314869 | False |
| 4070 | 1074 | 1074.0 | 23.2 | 23.2 | Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. | Linda J Pike | J Lipid Res | 2006 | 16645198 | False |
| 4071 | 2148 | 1074.0 | 41.6 | 20.8 | Phosphoinositides in cell regulation and membrane dynamics. | Gilbert Di Paolo, Pietro De Camilli | Nature | 2006 | 17035995 | False |
| 4072 | 1074 | 1074.0 | 30.7 | 30.7 | Cytochrome p450 and chemical toxicology. | F Peter Guengerich | Chem Res Toxicol | 2008 | 18052394 | False |
| 4073 | 1074 | 1074.0 | 25.5 | 25.5 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4074 | 1074 | 1074.0 | 23.4 | 23.4 | Principles and challenges of genomewide DNA methylation analysis. | Peter W Laird | Nat Rev Genet | 2010 | 20125086 | False |
| 4075 | 3221 | 1073.7 | 195.0 | 65.0 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade | Sci Rep | 2019 | 30626917 | Yes |
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