No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
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1 | 225455 | 225455.0 | 4294.8 | 4294.8 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
2 | 178065 | 178065.0 | 7014.2 | 7014.2 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
3 | 287723 | 71930.8 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
4 | 131990 | 65995.0 | 3253.6 | 1626.8 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
5 | 46223 | 46223.0 | 1382.58 | 1382.6 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
6 | 37928 | 37928.0 | 1221.2 | 1221.2 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
7 | 64635 | 32317.5 | 1935.92 | 968.0 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
8 | 30245 | 30245.0 | 823.2 | 823.2 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
9 | 28760 | 28760.0 | 884.88 | 884.9 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
10 | 28611 | 28611.0 | 668.16 | 668.2 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
11 | 28556 | 28556.0 | 622.06 | 622.1 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
12 | 26969 | 26969.0 | 690.49 | 690.5 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
13 | 25690 | 25690.0 | 584.95 | 585.0 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
14 | 25125 | 25125.0 | 783.39 | 783.4 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
15 | 45619 | 22809.5 | 1370.9 | 685.5 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
16 | 68413 | 22804.3 | 2505.21 | 835.1 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
17 | 66207 | 22069.0 | 1642.78 | 547.6 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
18 | 21627 | 21627.0 | 592.63 | 592.6 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
19 | 21282 | 21282.0 | 723.84 | 723.8 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
20 | 41197 | 20598.5 | 1273.96 | 637.0 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
21 | 20380 | 20380.0 | 204.54 | 204.5 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
22 | 20094 | 20094.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
23 | 38553 | 19276.5 | 1584.35 | 792.2 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
24 | 37512 | 18756.0 | 1757.58 | 878.8 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
25 | 18668 | 18668.0 | 752.73 | 752.7 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
26 | 54826 | 18275.3 | 1951.02 | 650.3 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
27 | 17987 | 17987.0 | 664.0 | 664.0 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
28 | 53544 | 17848.0 | 1993.12 | 664.4 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
29 | 17751 | 17751.0 | 727.59 | 727.6 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
30 | 53072 | 17690.7 | 1551.74 | 517.2 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
31 | 35098 | 17549.0 | 1073.12 | 536.6 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
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33 | 16762 | 16762.0 | 283.11 | 283.1 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
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35 | 33238 | 16619.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
36 | 16222 | 16222.0 | 449.63 | 449.6 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
37 | 32118 | 16059.0 | 1273.77 | 636.9 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
38 | 15928 | 15928.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
39 | 15871 | 15871.0 | 388.7 | 388.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
40 | 15794 | 15794.0 | 748.55 | 748.5 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
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43 | 45942 | 15314.0 | 1307.18 | 435.7 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
44 | 29355 | 14677.5 | 794.23 | 397.1 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
45 | 42890 | 14296.7 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
46 | 13302 | 13302.0 | 329.37 | 329.4 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
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48 | 65987 | 13197.4 | 1890.07 | 378.0 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
49 | 13013 | 13013.0 | 403.11 | 403.1 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
50 | 38912 | 12970.7 | 1445.53 | 481.8 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
51 | 12960 | 12960.0 | 498.71 | 498.7 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
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57 | 12654 | 12654.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
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76 | 10299 | 10299.0 | 201.38 | 201.4 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
77 | 10192 | 10192.0 | 433.29 | 433.3 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
78 | 10014 | 10014.0 | 282.96 | 283.0 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
79 | 9974 | 9974.0 | 278.95 | 278.9 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
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3972 | 1080 | 1080.0 | 27.5 | 27.5 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
3973 | 1080 | 1080.0 | 18.36 | 18.4 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
3974 | 1080 | 1080.0 | 23.06 | 23.1 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
3975 | 1080 | 1080.0 | 24.56 | 24.6 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | No |
3976 | 1080 | 1080.0 | 26.2 | 26.2 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | No |
3977 | 1080 | 1080.0 | 30.78 | 30.8 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | No |
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3980 | 1079 | 1079.0 | 27.07 | 27.1 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | No |
3981 | 1079 | 1079.0 | 29.15 | 29.1 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | No |
3982 | 1079 | 1079.0 | 33.26 | 33.3 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | No |
3983 | 1079 | 1079.0 | 36.15 | 36.1 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
3984 | 1079 | 1079.0 | 22.23 | 22.2 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | No |
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3994 | 1078 | 1078.0 | 32.9 | 32.9 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
3995 | 1078 | 1078.0 | 32.03 | 32.0 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
3996 | 1078 | 1078.0 | 36.73 | 36.7 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
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3998 | 1078 | 1078.0 | 27.21 | 27.2 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
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4017 | 1075 | 1075.0 | 32.3 | 32.3 | Topography of cognition: parallel distributed networks in primate association cortex. | P S Goldman-Rakic | Annu Rev Neurosci | 1988 | 3284439 | No |
4018 | 2150 | 1075.0 | 80.24 | 40.1 | A psychomotor stimulant theory of addiction. | R A Wise, M A Bozarth | Psychol Rev | 1987 | 3317472 | No |
4019 | 2150 | 1075.0 | 52.65 | 26.3 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | No |
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