Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 4103 papers with ECcit ≥ 1078.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 62, October 2025
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 225964 | 225964.0 | 4689.0 | 4689.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 179698 | 179698.0 | 7096.0 | 7096.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 288107 | 72026.8 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 136276 | 68138.0 | 3335.1 | 1667.5 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 46559 | 46559.0 | 1375.4 | 1375.4 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 38476 | 38476.0 | 1237.4 | 1237.4 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64721 | 32360.5 | 1931.5 | 965.8 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30254 | 30254.0 | 823.0 | 823.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 29342 | 29342.0 | 680.3 | 680.3 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 10 | 29270 | 29270.0 | 921.2 | 921.2 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 28879 | 28879.0 | 624.4 | 624.4 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | False |
| 12 | 27406 | 27406.0 | 699.2 | 699.2 | A rating scale for depression. | M HAMILTON | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 26192 | 26192.0 | 592.3 | 592.3 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 25437 | 25437.0 | 792.3 | 792.3 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 47014 | 23507.0 | 1390.9 | 695.5 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | False |
| 16 | 69498 | 23166.0 | 2535.6 | 845.2 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 17 | 22850 | 22850.0 | 622.5 | 622.5 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 18 | 66348 | 22116.0 | 1642.7 | 547.6 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 19 | 21731 | 21731.0 | 735.9 | 735.9 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 41679 | 20839.5 | 1285.6 | 642.8 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 21 | 20442 | 20442.0 | 204.2 | 204.2 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J Cell Biol | 1963 | 13986422 | Yes |
| 22 | 20351 | 20351.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 23 | 60058 | 20019.3 | 2094.5 | 698.2 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 24 | 39444 | 19722.0 | 1612.0 | 806.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 25 | 19409 | 19409.0 | 762.0 | 762.0 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 26 | 37850 | 18925.0 | 1763.8 | 881.9 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 27 | 37285 | 18642.5 | 1120.9 | 560.5 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 28 | 55683 | 18561.0 | 1618.9 | 539.6 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 29 | 18295 | 18295.0 | 673.0 | 673.0 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 30 | 18205 | 18205.0 | 743.9 | 743.9 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 31 | 53632 | 17877.3 | 2029.5 | 676.5 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 32 | 34917 | 17458.5 | 853.5 | 426.8 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 33 | 17295 | 17295.0 | 427.8 | 427.8 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | False |
| 34 | 33541 | 16770.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 35 | 16770 | 16770.0 | 283.1 | 283.1 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J DAVIS | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 36 | 16689 | 16689.0 | 766.5 | 766.5 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 37 | 33005 | 16502.5 | 1303.2 | 651.6 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 38 | 16226 | 16226.0 | 449.7 | 449.7 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 39 | 16085 | 16085.0 | 389.3 | 389.3 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | False |
| 40 | 15938 | 15938.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem J | 1956 | 13293190 | Yes |
| 41 | 31777 | 15888.5 | 1181.7 | 590.9 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 42 | 15832 | 15832.0 | 608.9 | 608.9 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 43 | 31083 | 15541.5 | 837.3 | 418.6 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 44 | 46277 | 15425.7 | 1312.2 | 437.4 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 45 | 43147 | 14382.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J Biol Chem | 1957 | 13428781 | Yes |
| 46 | 13962 | 13962.0 | 526.4 | 526.4 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 47 | 41666 | 13888.7 | 1511.6 | 503.9 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 48 | 13771 | 13771.0 | 336.1 | 336.1 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 49 | 27108 | 13554.0 | 546.3 | 273.1 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 50 | 67348 | 13469.6 | 1924.1 | 384.8 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 51 | 26807 | 13403.5 | 713.4 | 356.7 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 52 | 13342 | 13342.0 | 444.5 | 444.5 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 53 | 13322 | 13322.0 | 604.9 | 604.9 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 54 | 13286 | 13286.0 | 405.2 | 405.2 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 55 | 13135 | 13135.0 | 392.7 | 392.7 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 56 | 26251 | 13125.5 | 1061.1 | 530.5 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 57 | 26203 | 13101.5 | 942.9 | 471.4 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 58 | 39121 | 13040.3 | 1357.1 | 452.4 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 59 | 12770 | 12770.0 | 147.8 | 147.8 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 60 | 12658 | 12658.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J Biol Chem | 1959 | 13641241 | Yes |
| 61 | 25030 | 12515.0 | 532.3 | 266.1 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 62 | 12445 | 12445.0 | 407.4 | 407.4 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 63 | 37335 | 12445.0 | 964.6 | 321.5 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 64 | 12275 | 12275.0 | 513.2 | 513.2 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 65 | 36609 | 12203.0 | 1169.0 | 389.7 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | False |
| 66 | 24109 | 12054.5 | 518.4 | 259.2 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 67 | 11986 | 11986.0 | 450.9 | 450.9 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 68 | 46146 | 11536.5 | 1292.4 | 323.1 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | False |
| 69 | 11184 | 11184.0 | 503.5 | 503.5 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 70 | 22124 | 11062.0 | 926.4 | 463.2 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 71 | 10913 | 10913.0 | 277.3 | 277.3 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 72 | 10830 | 10830.0 | 355.5 | 355.5 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 73 | 21560 | 10780.0 | 555.7 | 277.9 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 74 | 10637 | 10637.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 75 | 10417 | 10417.0 | 439.9 | 439.9 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 76 | 10305 | 10305.0 | 201.2 | 201.2 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 77 | 10288 | 10288.0 | 282.6 | 282.6 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | False |
| 78 | 10197 | 10197.0 | 288.5 | 288.5 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 79 | 40533 | 10133.2 | 1469.3 | 367.3 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 80 | 10033 | 10033.0 | 203.5 | 203.5 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 81 | 39925 | 9981.2 | 1278.3 | 319.6 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 82 | 19815 | 9907.5 | 356.4 | 178.2 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 83 | 29567 | 9855.7 | 851.2 | 283.7 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 84 | 9782 | 9782.0 | 272.7 | 272.7 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | False |
| 85 | 29326 | 9775.3 | 748.5 | 249.5 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 86 | 9736 | 9736.0 | 228.7 | 228.7 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 87 | 19471 | 9735.5 | 496.7 | 248.3 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 88 | 19407 | 9703.5 | 497.7 | 248.8 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 89 | 9631 | 9631.0 | 248.1 | 248.1 | Canonical dynamics: Equilibrium phase-space distributions. | WG Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 90 | 9619 | 9619.0 | 317.1 | 317.1 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | False |
| 91 | 9601 | 9601.0 | 379.0 | 379.0 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 92 | 9593 | 9593.0 | 242.4 | 242.4 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 93 | 19176 | 9588.0 | 564.7 | 282.4 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 94 | 19021 | 9510.5 | 390.7 | 195.3 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | False |
| 95 | 9505 | 9505.0 | 250.8 | 250.8 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 96 | 28270 | 9423.3 | 696.9 | 232.3 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 97 | 9348 | 9348.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 98 | 9279 | 9279.0 | 236.1 | 236.1 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | False |
| 99 | 9254 | 9254.0 | 262.0 | 262.0 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 100 | 9203 | 9203.0 | 257.7 | 257.7 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | False |
| 101 | 18385 | 9192.5 | 392.4 | 196.2 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 102 | 9176 | 9176.0 | 235.6 | 235.6 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 103 | 18329 | 9164.5 | 420.4 | 210.2 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 104 | 9083 | 9083.0 | 232.0 | 232.0 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | False |
| 105 | 27091 | 9030.3 | 1345.2 | 448.4 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 106 | 8951 | 8951.0 | 176.6 | 176.6 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 107 | 8857 | 8857.0 | 258.7 | 258.7 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 108 | 8847 | 8847.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M HAMILTON | Br J Med Psychol | 1959 | 13638508 | Yes |
| 109 | 8832 | 8832.0 | 183.6 | 183.6 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | False |
| 110 | 17581 | 8790.5 | 576.1 | 288.1 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 111 | 34913 | 8728.2 | 1120.2 | 280.1 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 112 | 17125 | 8562.5 | 395.1 | 197.6 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 113 | 8525 | 8525.0 | 389.0 | 389.0 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 114 | 25325 | 8441.7 | 749.8 | 249.9 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 115 | 16744 | 8372.0 | 373.5 | 186.8 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 116 | 16520 | 8260.0 | 1000.9 | 500.4 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 117 | 8227 | 8227.0 | 222.2 | 222.2 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 118 | 8186 | 8186.0 | 341.1 | 341.1 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 119 | 8135 | 8135.0 | 195.4 | 195.4 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 120 | 16159 | 8079.5 | 387.9 | 193.9 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 121 | 8070 | 8070.0 | 195.6 | 195.6 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | False |
| 122 | 24087 | 8029.0 | 824.3 | 274.8 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 123 | 7980 | 7980.0 | 336.1 | 336.1 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 124 | 7954 | 7954.0 | 155.0 | 155.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | False |
| 125 | 7922 | 7922.0 | 247.1 | 247.1 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 126 | 7919 | 7919.0 | 218.1 | 218.1 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 127 | 7913 | 7913.0 | 164.0 | 164.0 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | False |
| 128 | 7863 | 7863.0 | 226.4 | 226.4 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 129 | 7826 | 7826.0 | 254.9 | 254.9 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 130 | 7825 | 7825.0 | 270.6 | 270.6 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 131 | 7800 | 7800.0 | 215.2 | 215.2 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | False |
| 132 | 23300 | 7766.7 | 902.8 | 300.9 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 133 | 7712 | 7712.0 | 229.8 | 229.8 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 134 | 7700 | 7700.0 | 218.4 | 218.4 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 135 | 7684 | 7684.0 | 220.2 | 220.2 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 136 | 15264 | 7632.0 | 417.3 | 208.7 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 137 | 53020 | 7574.3 | 1350.9 | 193.0 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | False |
| 138 | 7487 | 7487.0 | 192.0 | 192.0 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 139 | 7459 | 7459.0 | 242.9 | 242.9 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 140 | 14862 | 7431.0 | 395.1 | 197.6 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 141 | 7397 | 7397.0 | 119.2 | 119.2 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 142 | 14551 | 7275.5 | 373.3 | 186.7 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 143 | 7086 | 7086.0 | 191.7 | 191.7 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 144 | 14116 | 7058.0 | 772.6 | 386.3 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | False |
| 145 | 7005 | 7005.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J YOUDEN | Cancer | 1950 | 15405679 | Yes |
| 146 | 13962 | 6981.0 | 355.2 | 177.6 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 147 | 6857 | 6857.0 | 182.7 | 182.7 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | False |
| 148 | 6825 | 6825.0 | 116.9 | 116.9 | A Self-Rating Depression Scale. | W W ZUNG | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 149 | 6766 | 6766.0 | 131.7 | 131.7 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | False |
| 150 | 13522 | 6761.0 | 462.6 | 231.3 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 151 | 6714 | 6714.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L WARREN | J Biol Chem | 1959 | 13672998 | Yes |
| 152 | 6706 | 6706.0 | 216.8 | 216.8 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | False |
| 153 | 6704 | 6704.0 | 152.4 | 152.4 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 154 | 13368 | 6684.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N MANTEL, W HAENSZEL | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 155 | 6655 | 6655.0 | 152.8 | 152.8 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | False |
| 156 | 13303 | 6651.5 | 309.9 | 154.9 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 157 | 6622 | 6622.0 | 197.4 | 197.4 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | False |
| 158 | 19794 | 6598.0 | 551.9 | 184.0 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 159 | 6596 | 6596.0 | 169.0 | 169.0 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | False |
| 160 | 13186 | 6593.0 | 444.4 | 222.2 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 161 | 6574 | 6574.0 | 170.1 | 170.1 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | False |
| 162 | 6495 | 6495.0 | 152.4 | 152.4 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | False |
| 163 | 19417 | 6472.3 | 971.2 | 323.7 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 164 | 12929 | 6464.5 | 514.3 | 257.1 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 165 | 6449 | 6449.0 | 148.9 | 148.9 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 166 | 6428 | 6428.0 | 135.2 | 135.2 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | False |
| 167 | 6415 | 6415.0 | 128.8 | 128.8 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 168 | 6400 | 6400.0 | 147.0 | 147.0 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | False |
| 169 | 6400 | 6400.0 | 136.9 | 136.9 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | False |
| 170 | 6350 | 6350.0 | 116.6 | 116.6 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 171 | 37706 | 6284.3 | 1272.8 | 212.1 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 172 | 12421 | 6210.5 | 335.5 | 167.8 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | False |
| 173 | 6209 | 6209.0 | 168.9 | 168.9 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 174 | 6197 | 6197.0 | 270.2 | 270.2 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | False |
| 175 | 6193 | 6193.0 | 214.7 | 214.7 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | False |
| 176 | 6190 | 6190.0 | 139.9 | 139.9 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 177 | 6155 | 6155.0 | 198.4 | 198.4 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | False |
| 178 | 12289 | 6144.5 | 262.5 | 131.2 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 179 | 12284 | 6142.0 | 295.2 | 147.6 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 180 | 12278 | 6139.0 | 444.6 | 222.3 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 181 | 12272 | 6136.0 | 280.3 | 140.2 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 182 | 6113 | 6113.0 | 136.8 | 136.8 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 183 | 6110 | 6110.0 | 132.8 | 132.8 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 184 | 6093 | 6093.0 | 79.3 | 79.3 | The Environment And Disease: Association Or Causation? | A B HILL | Proc R Soc Med | 1965 | 14283879 | Yes |
| 185 | 6081 | 6081.0 | 152.5 | 152.5 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | False |
| 186 | 6078 | 6078.0 | 146.9 | 146.9 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | False |
| 187 | 6049 | 6049.0 | 151.1 | 151.1 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | False |
| 188 | 6048 | 6048.0 | 184.3 | 184.3 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 189 | 23969 | 5992.2 | 788.9 | 197.2 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 190 | 11832 | 5916.0 | 389.6 | 194.8 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 191 | 11676 | 5838.0 | 451.3 | 225.7 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 192 | 5832 | 5832.0 | 152.4 | 152.4 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | False |
| 193 | 5830 | 5830.0 | 141.3 | 141.3 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 194 | 5805 | 5805.0 | 178.1 | 178.1 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 195 | 5801 | 5801.0 | 149.2 | 149.2 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | False |
| 196 | 5792 | 5792.0 | 229.1 | 229.1 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 197 | 11578 | 5789.0 | 245.2 | 122.6 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 198 | 11572 | 5786.0 | 283.3 | 141.7 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 199 | 5776 | 5776.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D HARMAN | J Gerontol | 1956 | 13332224 | Yes |
| 200 | 23095 | 5773.8 | 662.8 | 165.7 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 201 | 23058 | 5764.5 | 563.2 | 140.8 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 202 | 11524 | 5762.0 | 239.4 | 119.7 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | False |
| 203 | 11455 | 5727.5 | 193.7 | 96.8 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T OMURA, R SATO | J Biol Chem | 1964 | 14209971 | Yes |
| 204 | 5722 | 5722.0 | 142.3 | 142.3 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | False |
| 205 | 11431 | 5715.5 | 248.0 | 124.0 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | False |
| 206 | 5704 | 5704.0 | 119.3 | 119.3 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 207 | 17101 | 5700.3 | 528.7 | 176.2 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 208 | 11397 | 5698.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V HAMBURGER, H L HAMILTON | J Morphol | 1951 | 24539719 | Yes |
| 209 | 5693 | 5693.0 | 212.5 | 212.5 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 210 | 17053 | 5684.3 | 629.6 | 209.9 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 211 | 5671 | 5671.0 | 94.9 | 94.9 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 212 | 22664 | 5666.0 | 677.5 | 169.4 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 213 | 5618 | 5618.0 | 566.2 | 566.2 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | False |
| 214 | 11232 | 5616.0 | 530.6 | 265.3 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 215 | 11211 | 5605.5 | 255.9 | 128.0 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 216 | 5601 | 5601.0 | 213.7 | 213.7 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 217 | 5590 | 5590.0 | 89.5 | 89.5 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 218 | 5579 | 5579.0 | 118.8 | 118.8 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | False |
| 219 | 16684 | 5561.3 | 499.9 | 166.6 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 220 | 5551 | 5551.0 | 163.1 | 163.1 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 221 | 11034 | 5517.0 | 293.4 | 146.7 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 222 | 11005 | 5502.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L HODGKIN, A F HUXLEY | J Physiol | 1952 | 12991237 | Yes |
| 223 | 10927 | 5463.5 | 285.8 | 142.9 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 224 | 16354 | 5451.3 | 398.0 | 132.7 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 225 | 16285 | 5428.3 | 637.8 | 212.6 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 226 | 5412 | 5412.0 | 103.3 | 103.3 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | False |
| 227 | 10786 | 5393.0 | 299.9 | 149.9 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 228 | 5388 | 5388.0 | 135.9 | 135.9 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 229 | 16138 | 5379.3 | 637.4 | 212.5 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | False |
| 230 | 5367 | 5367.0 | 54.3 | 54.3 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P LAUREN | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 231 | 26781 | 5356.2 | 717.9 | 143.6 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 232 | 10671 | 5335.5 | 354.0 | 177.0 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | False |
| 233 | 5321 | 5321.0 | 127.2 | 127.2 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | False |
| 234 | 5316 | 5316.0 | 127.2 | 127.2 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | False |
| 235 | 5308 | 5308.0 | 104.1 | 104.1 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | False |
| 236 | 5307 | 5307.0 | 134.8 | 134.8 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 237 | 10613 | 5306.5 | 226.0 | 113.0 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | False |
| 238 | 10563 | 5281.5 | 249.3 | 124.7 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 239 | 5268 | 5268.0 | 151.8 | 151.8 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | False |
| 240 | 5223 | 5223.0 | 188.3 | 188.3 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | False |
| 241 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J SCHEIDEGGER | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 242 | 5199 | 5199.0 | 68.3 | 68.3 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 243 | 10379 | 5189.5 | 365.1 | 182.6 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 244 | 10376 | 5188.0 | 179.1 | 89.5 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 245 | 5181 | 5181.0 | 229.7 | 229.7 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | False |
| 246 | 5147 | 5147.0 | 101.4 | 101.4 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | False |
| 247 | 10268 | 5134.0 | 271.6 | 135.8 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 248 | 10252 | 5126.0 | 167.9 | 84.0 | Functional Evaluation: The Barthel Index. | F I MAHONEY, D W BARTHEL | Md State Med J | 1965 | 14258950 | Yes |
| 249 | 25611 | 5122.2 | 1041.1 | 208.2 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 250 | 5122 | 5122.0 | 187.8 | 187.8 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 251 | 5085 | 5085.0 | 144.4 | 144.4 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 252 | 10169 | 5084.5 | 264.8 | 132.4 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 253 | 15242 | 5080.7 | 535.4 | 178.5 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 254 | 5070 | 5070.0 | 154.1 | 154.1 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | False |
| 255 | 10134 | 5067.0 | 237.9 | 119.0 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | False |
| 256 | 5052 | 5052.0 | 112.8 | 112.8 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 257 | 15149 | 5049.7 | 501.2 | 167.1 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 258 | 10085 | 5042.5 | 354.8 | 177.4 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 259 | 25042 | 5008.4 | 420.8 | 84.2 | An inventory for measuring depression. | A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 260 | 14994 | 4998.0 | 651.6 | 217.2 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 261 | 14984 | 4994.7 | 472.5 | 157.5 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 262 | 4994 | 4994.0 | 91.4 | 91.4 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | False |
| 263 | 14977 | 4992.3 | 539.7 | 179.9 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 264 | 4949 | 4949.0 | 122.8 | 122.8 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 265 | 9872 | 4936.0 | 222.9 | 111.5 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 266 | 4911 | 4911.0 | 156.1 | 156.1 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 267 | 19570 | 4892.5 | 314.0 | 78.5 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 268 | 9783 | 4891.5 | 349.4 | 174.7 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 269 | 14651 | 4883.7 | 392.5 | 130.8 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 270 | 4882 | 4882.0 | 97.4 | 97.4 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | False |
| 271 | 14511 | 4837.0 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G GORNALL, C J BARDAWILL, M M DAVID | J Biol Chem | 1949 | 18110453 | Yes |
| 272 | 4835 | 4835.0 | 112.4 | 112.4 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 273 | 4828 | 4828.0 | 207.3 | 207.3 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 274 | 4815 | 4815.0 | 107.3 | 107.3 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | False |
| 275 | 14441 | 4813.7 | 356.3 | 118.8 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 276 | 4807 | 4807.0 | 57.5 | 57.5 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M RODBELL | J Biol Chem | 1964 | 14169133 | Yes |
| 277 | 4800 | 4800.0 | 104.7 | 104.7 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | False |
| 278 | 9599 | 4799.5 | 352.1 | 176.1 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 279 | 4798 | 4798.0 | 103.7 | 103.7 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | False |
| 280 | 19183 | 4795.8 | 596.8 | 149.2 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
| 281 | 9565 | 4782.5 | 227.0 | 113.5 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 282 | 4774 | 4774.0 | 41.3 | 41.3 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L HAYFLICK | Exp Cell Res | 1965 | 14315085 | Yes |
| 283 | 14312 | 4770.7 | 308.8 | 102.9 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 284 | 4766 | 4766.0 | 104.3 | 104.3 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | False |
| 285 | 33351 | 4764.4 | 722.9 | 103.3 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 286 | 9522 | 4761.0 | 158.7 | 79.3 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 287 | 9482 | 4741.0 | 386.1 | 193.1 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 288 | 9460 | 4730.0 | 236.6 | 118.3 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 289 | 4718 | 4718.0 | 94.5 | 94.5 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | False |
| 290 | 4706 | 4706.0 | 156.1 | 156.1 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | False |
| 291 | 4706 | 4706.0 | 264.7 | 264.7 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V BORN | Nature | 1962 | 13871375 | Yes |
| 292 | 9380 | 4690.0 | 136.5 | 68.2 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 293 | 4678 | 4678.0 | 129.6 | 129.6 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 294 | 18679 | 4669.8 | 522.9 | 130.7 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 295 | 4653 | 4653.0 | 120.6 | 120.6 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 296 | 9299 | 4649.5 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H KELLGREN, J S LAWRENCE | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 297 | 4646 | 4646.0 | 48.8 | 48.8 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 298 | 4626 | 4626.0 | 141.6 | 141.6 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 299 | 9226 | 4613.0 | 202.1 | 101.0 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 300 | 13830 | 4610.0 | 474.5 | 158.2 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | False |
| 301 | 4605 | 4605.0 | 95.5 | 95.5 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 302 | 9200 | 4600.0 | 229.8 | 114.9 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 303 | 9187 | 4593.5 | 227.7 | 113.8 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 304 | 4592 | 4592.0 | 170.5 | 170.5 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | False |
| 305 | 4582 | 4582.0 | 104.1 | 104.1 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | False |
| 306 | 4582 | 4582.0 | 164.4 | 164.4 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | False |
| 307 | 4577 | 4577.0 | 91.4 | 91.4 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | False |
| 308 | 9152 | 4576.0 | 351.6 | 175.8 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
| 309 | 4560 | 4560.0 | 125.5 | 125.5 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 310 | 9114 | 4557.0 | 249.1 | 124.5 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 311 | 4547 | 4547.0 | 96.6 | 96.6 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | False |
| 312 | 9090 | 4545.0 | 261.5 | 130.8 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 313 | 22700 | 4540.0 | 862.1 | 172.4 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 314 | 9065 | 4532.5 | 240.7 | 120.3 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | False |
| 315 | 9045 | 4522.5 | 207.4 | 103.7 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 316 | 4522 | 4522.0 | 90.9 | 90.9 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 317 | 4504 | 4504.0 | 131.8 | 131.8 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 318 | 4495 | 4495.0 | 162.7 | 162.7 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 319 | 4493 | 4493.0 | 86.4 | 86.4 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 320 | 13466 | 4488.7 | 492.8 | 164.3 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 321 | 4487 | 4487.0 | 84.2 | 84.2 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | False |
| 322 | 8963 | 4481.5 | 284.4 | 142.2 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 323 | 8932 | 4466.0 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T LITCHFIELD, F WILCOXON | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 324 | 4436 | 4436.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B DE B WEIR | J Physiol | 1949 | 15394301 | Yes |
| 325 | 4435 | 4435.0 | 107.5 | 107.5 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 326 | 26517 | 4419.5 | 858.2 | 143.0 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 327 | 26446 | 4407.7 | 920.4 | 153.4 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 328 | 4404 | 4404.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 329 | 4397 | 4397.0 | 102.0 | 102.0 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | False |
| 330 | 8765 | 4382.5 | 162.1 | 81.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 331 | 4382 | 4382.0 | 120.9 | 120.9 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 332 | 4378 | 4378.0 | 132.8 | 132.8 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | False |
| 333 | 4377 | 4377.0 | 93.0 | 93.0 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | False |
| 334 | 4365 | 4365.0 | 112.0 | 112.0 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | False |
| 335 | 4355 | 4355.0 | 110.9 | 110.9 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 336 | 4353 | 4353.0 | 221.9 | 221.9 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 337 | 4351 | 4351.0 | 104.0 | 104.0 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | False |
| 338 | 8697 | 4348.5 | 205.6 | 102.8 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 339 | 4341 | 4341.0 | 90.7 | 90.7 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 340 | 4341 | 4341.0 | 110.1 | 110.1 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 341 | 4339 | 4339.0 | 111.1 | 111.1 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | False |
| 342 | 4327 | 4327.0 | 127.9 | 127.9 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | False |
| 343 | 8591 | 4295.5 | 265.2 | 132.6 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 344 | 8582 | 4291.0 | 218.4 | 109.2 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 345 | 8580 | 4290.0 | 465.7 | 232.8 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M HUNTER, F C GREENWOOD | Nature | 1962 | 14450081 | Yes |
| 346 | 4288 | 4288.0 | 118.0 | 118.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 347 | 4274 | 4274.0 | 112.7 | 112.7 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | False |
| 348 | 8547 | 4273.5 | 225.2 | 112.6 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 349 | 4272 | 4272.0 | 93.7 | 93.7 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 350 | 4272 | 4272.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M ABERCROMBIE | Anat Rec | 1946 | 21015608 | Yes |
| 351 | 4271 | 4271.0 | 87.7 | 87.7 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | False |
| 352 | 4267 | 4267.0 | 91.6 | 91.6 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | False |
| 353 | 4259 | 4259.0 | 75.6 | 75.6 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 354 | 4258 | 4258.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T NASH | Biochem J | 1953 | 13105648 | Yes |
| 355 | 4247 | 4247.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H EAGLE | Science | 1959 | 13675766 | Yes |
| 356 | 8480 | 4240.0 | 212.5 | 106.2 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | False |
| 357 | 4238 | 4238.0 | 173.9 | 173.9 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 358 | 4232 | 4232.0 | 107.3 | 107.3 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 359 | 4231 | 4231.0 | 105.2 | 105.2 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | False |
| 360 | 4228 | 4228.0 | 109.0 | 109.0 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 361 | 4226 | 4226.0 | 141.0 | 141.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 362 | 4221 | 4221.0 | 51.2 | 51.2 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 363 | 4221 | 4221.0 | 93.8 | 93.8 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 364 | 4220 | 4220.0 | 86.6 | 86.6 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | False |
| 365 | 4211 | 4211.0 | 112.5 | 112.5 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | False |
| 366 | 21005 | 4201.0 | 1233.2 | 246.6 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 367 | 4200 | 4200.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P DOLE | J Clin Invest | 1956 | 13286333 | Yes |
| 368 | 4196 | 4196.0 | 119.8 | 119.8 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 369 | 4194 | 4194.0 | 80.4 | 80.4 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | False |
| 370 | 4193 | 4193.0 | 86.5 | 86.5 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | False |
| 371 | 4188 | 4188.0 | 174.8 | 174.8 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 372 | 4184 | 4184.0 | 73.2 | 73.2 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 373 | 12519 | 4173.0 | 318.7 | 106.2 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 374 | 4165 | 4165.0 | 100.4 | 100.4 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | False |
| 375 | 4162 | 4162.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M DIXON | Biochem J | 1953 | 13093635 | Yes |
| 376 | 8314 | 4157.0 | 216.1 | 108.0 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | False |
| 377 | 4153 | 4153.0 | 109.7 | 109.7 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | False |
| 378 | 8280 | 4140.0 | 177.4 | 88.7 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 379 | 4135 | 4135.0 | 127.7 | 127.7 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | False |
| 380 | 8265 | 4132.5 | 177.2 | 88.6 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 381 | 4130 | 4130.0 | 111.1 | 111.1 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 382 | 4122 | 4122.0 | 98.5 | 98.5 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 383 | 4104 | 4104.0 | 85.6 | 85.6 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | False |
| 384 | 8189 | 4094.5 | 191.8 | 95.9 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | False |
| 385 | 4090 | 4090.0 | 99.9 | 99.9 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 386 | 16356 | 4089.0 | 366.5 | 91.6 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 387 | 4073 | 4073.0 | 101.4 | 101.4 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | False |
| 388 | 4065 | 4065.0 | 106.5 | 106.5 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 389 | 4051 | 4051.0 | 112.7 | 112.7 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | False |
| 390 | 4036 | 4036.0 | 132.7 | 132.7 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | False |
| 391 | 4017 | 4017.0 | 106.9 | 106.9 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | False |
| 392 | 4017 | 4017.0 | 103.0 | 103.0 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | False |
| 393 | 8034 | 4017.0 | 194.6 | 97.3 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | False |
| 394 | 8031 | 4015.5 | 151.3 | 75.7 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 395 | 12023 | 4007.7 | 322.2 | 107.4 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | False |
| 396 | 4007 | 4007.0 | 81.8 | 81.8 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 397 | 4005 | 4005.0 | 114.5 | 114.5 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | False |
| 398 | 4000 | 4000.0 | 127.9 | 127.9 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | False |
| 399 | 8000 | 4000.0 | 150.4 | 75.2 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 400 | 3989 | 3989.0 | 90.7 | 90.7 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | False |
| 401 | 3973 | 3973.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L WATSON | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 402 | 3970 | 3970.0 | 68.2 | 68.2 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 403 | 3970 | 3970.0 | 82.1 | 82.1 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | False |
| 404 | 7922 | 3961.0 | 195.4 | 97.7 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | False |
| 405 | 3953 | 3953.0 | 86.5 | 86.5 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | False |
| 406 | 3950 | 3950.0 | 95.5 | 95.5 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | False |
| 407 | 7868 | 3934.0 | 258.8 | 129.4 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 408 | 7849 | 3924.5 | 219.0 | 109.5 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 409 | 7845 | 3922.5 | 211.3 | 105.7 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 410 | 3922 | 3922.0 | 112.2 | 112.2 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | False |
| 411 | 11766 | 3922.0 | 278.9 | 93.0 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | False |
| 412 | 3920 | 3920.0 | 120.3 | 120.3 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | False |
| 413 | 15678 | 3919.5 | 554.1 | 138.5 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 414 | 3915 | 3915.0 | 64.0 | 64.0 | Disc Electrophoresis. I. Background And Theory. | L ORNSTEIN | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 415 | 3897 | 3897.0 | 142.9 | 142.9 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | False |
| 416 | 3895 | 3895.0 | 119.1 | 119.1 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 417 | 3885 | 3885.0 | 75.8 | 75.8 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 418 | 3879 | 3879.0 | 111.9 | 111.9 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 419 | 3877 | 3877.0 | 103.5 | 103.5 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 420 | 3876 | 3876.0 | 140.0 | 140.0 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 421 | 3872 | 3872.0 | 174.0 | 174.0 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 422 | 3863 | 3863.0 | 125.1 | 125.1 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | False |
| 423 | 3863 | 3863.0 | 90.8 | 90.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | False |
| 424 | 3860 | 3860.0 | 90.5 | 90.5 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 425 | 3858 | 3858.0 | 90.8 | 90.8 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 426 | 3853 | 3853.0 | 88.4 | 88.4 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 427 | 3849 | 3849.0 | 116.6 | 116.6 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 428 | 3848 | 3848.0 | 108.9 | 108.9 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | False |
| 429 | 3845 | 3845.0 | 122.4 | 122.4 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 430 | 3836 | 3836.0 | 115.1 | 115.1 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 431 | 3826 | 3826.0 | 102.5 | 102.5 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 432 | 3824 | 3824.0 | 93.3 | 93.3 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | False |
| 433 | 3818 | 3818.0 | 97.9 | 97.9 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | False |
| 434 | 3803 | 3803.0 | 77.6 | 77.6 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | False |
| 435 | 7598 | 3799.0 | 180.9 | 90.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | False |
| 436 | 3795 | 3795.0 | 79.2 | 79.2 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 437 | 3790 | 3790.0 | 89.6 | 89.6 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
| 438 | 15125 | 3781.2 | 691.4 | 172.8 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 439 | 33970 | 3774.4 | 1023.1 | 113.7 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 440 | 3773 | 3773.0 | 98.6 | 98.6 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | False |
| 441 | 7531 | 3765.5 | 163.4 | 81.7 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | False |
| 442 | 3760 | 3760.0 | 119.2 | 119.2 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 443 | 33817 | 3757.4 | 718.0 | 79.8 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 444 | 3757 | 3757.0 | 65.3 | 65.3 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 445 | 3753 | 3753.0 | 107.2 | 107.2 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 446 | 26196 | 3742.3 | 906.0 | 129.4 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 447 | 11224 | 3741.3 | 213.9 | 71.3 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 448 | 3730 | 3730.0 | 66.0 | 66.0 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | False |
| 449 | 3718 | 3718.0 | 90.5 | 90.5 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | False |
| 450 | 11144 | 3714.7 | 355.0 | 118.3 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 451 | 7426 | 3713.0 | 375.0 | 187.5 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 452 | 7425 | 3712.5 | 172.9 | 86.5 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 453 | 3706 | 3706.0 | 164.8 | 164.8 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | False |
| 454 | 11114 | 3704.7 | 259.0 | 86.3 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 455 | 3704 | 3704.0 | 68.4 | 68.4 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 456 | 14811 | 3702.8 | 604.6 | 151.2 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 457 | 3698 | 3698.0 | 101.7 | 101.7 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | False |
| 458 | 7384 | 3692.0 | 221.4 | 110.7 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 459 | 3688 | 3688.0 | 95.9 | 95.9 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | False |
| 460 | 3678 | 3678.0 | 76.2 | 76.2 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | False |
| 461 | 3631 | 3631.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A MILLER | Psychol Rev | 1956 | 13310704 | Yes |
| 462 | 3627 | 3627.0 | 115.3 | 115.3 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 463 | 3625 | 3625.0 | 84.2 | 84.2 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | False |
| 464 | 7240 | 3620.0 | 203.4 | 101.7 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 465 | 3618 | 3618.0 | 80.9 | 80.9 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | False |
| 466 | 7231 | 3615.5 | 128.3 | 64.2 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | False |
| 467 | 3614 | 3614.0 | 166.2 | 166.2 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 468 | 3609 | 3609.0 | 108.3 | 108.3 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | False |
| 469 | 3608 | 3608.0 | 80.3 | 80.3 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | False |
| 470 | 3607 | 3607.0 | 70.9 | 70.9 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | False |
| 471 | 7210 | 3605.0 | 363.8 | 181.9 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H HUBEL, T N WIESEL | J Physiol | 1962 | 14449617 | Yes |
| 472 | 3591 | 3591.0 | 54.7 | 54.7 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 473 | 3588 | 3588.0 | 67.0 | 67.0 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | False |
| 474 | 7170 | 3585.0 | 167.6 | 83.8 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 475 | 3584 | 3584.0 | 106.0 | 106.0 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | False |
| 476 | 7167 | 3583.5 | 223.4 | 111.7 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 477 | 3582 | 3582.0 | 117.1 | 117.1 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 478 | 7158 | 3579.0 | 262.0 | 131.0 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 479 | 3570 | 3570.0 | 138.7 | 138.7 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 480 | 3561 | 3561.0 | 91.3 | 91.3 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | False |
| 481 | 7120 | 3560.0 | 137.4 | 68.7 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 482 | 3559 | 3559.0 | 124.1 | 124.1 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | False |
| 483 | 3550 | 3550.0 | 76.4 | 76.4 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | False |
| 484 | 10636 | 3545.3 | 249.5 | 83.2 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 485 | 7080 | 3540.0 | 208.3 | 104.2 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | False |
| 486 | 3539 | 3539.0 | 85.6 | 85.6 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | False |
| 487 | 3536 | 3536.0 | 84.9 | 84.9 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | False |
| 488 | 7068 | 3534.0 | 145.8 | 72.9 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 489 | 3523 | 3523.0 | 57.0 | 57.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 490 | 3523 | 3523.0 | 132.7 | 132.7 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | False |
| 491 | 17574 | 3514.8 | 494.3 | 98.9 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 492 | 3511 | 3511.0 | 52.3 | 52.3 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F WOESSNER | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 493 | 3504 | 3504.0 | 94.2 | 94.2 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | False |
| 494 | 3502 | 3502.0 | 97.9 | 97.9 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 495 | 6995 | 3497.5 | 196.2 | 98.1 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | False |
| 496 | 3497 | 3497.0 | 87.5 | 87.5 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | False |
| 497 | 6987 | 3493.5 | 132.5 | 66.2 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | False |
| 498 | 3485 | 3485.0 | 58.9 | 58.9 | Statistical estimations in enzyme kinetics. | G N WILKINSON | Biochem J | 1961 | 13785321 | Yes |
| 499 | 3479 | 3479.0 | 120.7 | 120.7 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | False |
| 500 | 10433 | 3477.7 | 248.1 | 82.7 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 501 | 3469 | 3469.0 | 108.5 | 108.5 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | False |
| 502 | 3466 | 3466.0 | 80.1 | 80.1 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | False |
| 503 | 38030 | 3457.3 | 779.7 | 70.9 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 504 | 3457 | 3457.0 | 94.6 | 94.6 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 505 | 6899 | 3449.5 | 182.5 | 91.2 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 506 | 3448 | 3448.0 | 76.4 | 76.4 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | False |
| 507 | 6886 | 3443.0 | 405.6 | 202.8 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | False |
| 508 | 6885 | 3442.5 | 206.4 | 103.2 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 509 | 6881 | 3440.5 | 160.3 | 80.2 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | False |
| 510 | 3439 | 3439.0 | 69.1 | 69.1 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | False |
| 511 | 6877 | 3438.5 | 182.1 | 91.0 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 512 | 6874 | 3437.0 | 162.4 | 81.2 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 513 | 3432 | 3432.0 | 76.9 | 76.9 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | False |
| 514 | 6857 | 3428.5 | 142.8 | 71.4 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | False |
| 515 | 3427 | 3427.0 | 81.8 | 81.8 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | False |
| 516 | 6850 | 3425.0 | 171.6 | 85.8 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | False |
| 517 | 3420 | 3420.0 | 65.3 | 65.3 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | False |
| 518 | 3417 | 3417.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W KAUZMANN | Adv Protein Chem | 1959 | 14404936 | Yes |
| 519 | 3411 | 3411.0 | 81.9 | 81.9 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | False |
| 520 | 3404 | 3404.0 | 91.3 | 91.3 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 521 | 3390 | 3390.0 | 69.7 | 69.7 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | False |
| 522 | 6778 | 3389.0 | 171.3 | 85.7 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | False |
| 523 | 3387 | 3387.0 | 135.5 | 135.5 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 524 | 10148 | 3382.7 | 98.2 | 32.7 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C GREENWOOD, W M HUNTER, J S GLOVER | Biochem J | 1963 | 14097352 | Yes |
| 525 | 3371 | 3371.0 | 112.9 | 112.9 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 526 | 6740 | 3370.0 | 210.1 | 105.0 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 527 | 6735 | 3367.5 | 203.7 | 101.8 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 528 | 6734 | 3367.0 | 211.3 | 105.7 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 529 | 3365 | 3365.0 | 68.5 | 68.5 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | False |
| 530 | 3365 | 3365.0 | 68.5 | 68.5 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | False |
| 531 | 3361 | 3361.0 | 76.6 | 76.6 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
| 532 | 26862 | 3357.8 | 572.6 | 71.6 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 533 | 6691 | 3345.5 | 187.6 | 93.8 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 534 | 6679 | 3339.5 | 216.6 | 108.3 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | False |
| 535 | 6671 | 3335.5 | 159.9 | 80.0 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 536 | 3335 | 3335.0 | 68.0 | 68.0 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 537 | 3329 | 3329.0 | 60.2 | 60.2 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | False |
| 538 | 9976 | 3325.3 | 275.7 | 91.9 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 539 | 3325 | 3325.0 | 100.0 | 100.0 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | False |
| 540 | 3320 | 3320.0 | 87.8 | 87.8 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | False |
| 541 | 6636 | 3318.0 | 270.2 | 135.1 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 542 | 3311 | 3311.0 | 106.7 | 106.7 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 543 | 6621 | 3310.5 | 56.7 | 28.4 | The serial cultivation of human diploid cell strains. | L HAYFLICK, P S MOORHEAD | Exp Cell Res | 1961 | 13905658 | Yes |
| 544 | 6616 | 3308.0 | 184.2 | 92.1 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | False |
| 545 | 3303 | 3303.0 | 83.7 | 83.7 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | False |
| 546 | 3299 | 3299.0 | 46.2 | 46.2 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A YPHANTIS | Biochemistry | 1964 | 14155091 | Yes |
| 547 | 9895 | 3298.3 | 270.8 | 90.3 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hänzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 548 | 9885 | 3295.0 | 990.0 | 330.0 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 549 | 6587 | 3293.5 | 105.4 | 52.7 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | False |
| 550 | 3292 | 3292.0 | 94.3 | 94.3 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 551 | 3280 | 3280.0 | 64.1 | 64.1 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | False |
| 552 | 3278 | 3278.0 | 69.5 | 69.5 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | False |
| 553 | 13087 | 3271.8 | 488.7 | 122.2 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 554 | 3267 | 3267.0 | 77.7 | 77.7 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | False |
| 555 | 3259 | 3259.0 | 110.7 | 110.7 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | False |
| 556 | 13035 | 3258.8 | 741.9 | 185.5 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 557 | 6509 | 3254.5 | 161.6 | 80.8 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | False |
| 558 | 9759 | 3253.0 | 471.5 | 157.2 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | False |
| 559 | 12997 | 3249.2 | 298.3 | 74.6 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 560 | 6497 | 3248.5 | 161.7 | 80.8 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | False |
| 561 | 3248 | 3248.0 | 66.0 | 66.0 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | False |
| 562 | 3246 | 3246.0 | 125.2 | 125.2 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | False |
| 563 | 3243 | 3243.0 | 93.1 | 93.1 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | False |
| 564 | 9718 | 3239.3 | 180.3 | 60.1 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 565 | 6478 | 3239.0 | 579.1 | 289.6 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 566 | 3235 | 3235.0 | 52.0 | 52.0 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L HORN | Psychometrika | 1965 | 14306381 | Yes |
| 567 | 3234 | 3234.0 | 73.8 | 73.8 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 568 | 3234 | 3234.0 | 74.6 | 74.6 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | False |
| 569 | 6464 | 3232.0 | 133.7 | 66.8 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | False |
| 570 | 9693 | 3231.0 | 273.3 | 91.1 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 571 | 3229 | 3229.0 | 66.5 | 66.5 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | False |
| 572 | 3217 | 3217.0 | 66.0 | 66.0 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | False |
| 573 | 3209 | 3209.0 | 58.9 | 58.9 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 574 | 3206 | 3206.0 | 27.3 | 27.3 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F LYON | Nature | 1961 | 13764598 | Yes |
| 575 | 3200 | 3200.0 | 66.4 | 66.4 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | False |
| 576 | 3198 | 3198.0 | 70.0 | 70.0 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | False |
| 577 | 3187 | 3187.0 | 142.0 | 142.0 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 578 | 6367 | 3183.5 | 110.0 | 55.0 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 579 | 3176 | 3176.0 | 73.5 | 73.5 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | False |
| 580 | 9524 | 3174.7 | 402.2 | 134.1 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 581 | 9513 | 3171.0 | 193.9 | 64.6 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 582 | 3171 | 3171.0 | 86.6 | 86.6 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | False |
| 583 | 3169 | 3169.0 | 108.8 | 108.8 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 584 | 3168 | 3168.0 | 126.6 | 126.6 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | False |
| 585 | 6328 | 3164.0 | 135.8 | 67.9 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | False |
| 586 | 3163 | 3163.0 | 74.2 | 74.2 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 587 | 3162 | 3162.0 | 85.4 | 85.4 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | False |
| 588 | 3160 | 3160.0 | 77.6 | 77.6 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | False |
| 589 | 6320 | 3160.0 | 139.9 | 70.0 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | False |
| 590 | 12606 | 3151.5 | 358.4 | 89.6 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 591 | 3146 | 3146.0 | 97.4 | 97.4 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 592 | 3140 | 3140.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O OUCHTERLONY | Prog Allergy | 1958 | 13578996 | Yes |
| 593 | 3140 | 3140.0 | 70.6 | 70.6 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | False |
| 594 | 6279 | 3139.5 | 291.9 | 145.9 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | False |
| 595 | 6276 | 3138.0 | 148.0 | 74.0 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 596 | 3136 | 3136.0 | 105.1 | 105.1 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 597 | 6264 | 3132.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S REITMAN, S FRANKEL | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 598 | 3131 | 3131.0 | 72.6 | 72.6 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 599 | 3126 | 3126.0 | 68.5 | 68.5 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | False |
| 600 | 3124 | 3124.0 | 92.9 | 92.9 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | False |
| 601 | 3124 | 3124.0 | 85.7 | 85.7 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | False |
| 602 | 6246 | 3123.0 | 161.1 | 80.5 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 603 | 6245 | 3122.5 | 130.3 | 65.2 | Emergence of scaling in random networks | A L Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 604 | 3116 | 3116.0 | 152.9 | 152.9 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | False |
| 605 | 9343 | 3114.3 | 311.3 | 103.8 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 606 | 3107 | 3107.0 | 73.8 | 73.8 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 607 | 3088 | 3088.0 | 153.1 | 153.1 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | False |
| 608 | 3087 | 3087.0 | 92.8 | 92.8 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 609 | 9229 | 3076.3 | 296.9 | 99.0 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 610 | 12300 | 3075.0 | 284.0 | 71.0 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 611 | 6140 | 3070.0 | 125.7 | 62.9 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | False |
| 612 | 9208 | 3069.3 | 204.4 | 68.1 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 613 | 3066 | 3066.0 | 86.0 | 86.0 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 614 | 9198 | 3066.0 | 212.0 | 70.7 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 615 | 3059 | 3059.0 | 59.5 | 59.5 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | False |
| 616 | 3057 | 3057.0 | 47.7 | 47.7 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S HAKOMORI | J Biochem | 1964 | 14135466 | Yes |
| 617 | 3056 | 3056.0 | 70.1 | 70.1 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | False |
| 618 | 3056 | 3056.0 | 93.8 | 93.8 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 619 | 3048 | 3048.0 | 103.4 | 103.4 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | False |
| 620 | 9110 | 3036.7 | 229.4 | 76.5 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 621 | 3036 | 3036.0 | 94.9 | 94.9 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 622 | 3034 | 3034.0 | 55.1 | 55.1 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | False |
| 623 | 9086 | 3028.7 | 175.2 | 58.4 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 624 | 3028 | 3028.0 | 30.1 | 30.1 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P MITCHELL | Nature | 1961 | 13771349 | Yes |
| 625 | 6055 | 3027.5 | 187.5 | 93.8 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | False |
| 626 | 3022 | 3022.0 | 111.0 | 111.0 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | False |
| 627 | 18115 | 3019.2 | 873.5 | 145.6 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 628 | 3018 | 3018.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I SELDINGER | Acta Radiol (Stockh) | 1953 | 13057644 | Yes |
| 629 | 6035 | 3017.5 | 191.4 | 95.7 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | False |
| 630 | 6024 | 3012.0 | 238.6 | 119.3 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 631 | 3011 | 3011.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E PALADE | J Exp Med | 1952 | 14927794 | Yes |
| 632 | 3011 | 3011.0 | 0.0 | 0.0 | The genetical structure of populations. | S WRIGHT | Ann Eugen | 1951 | 24540312 | Yes |
| 633 | 6005 | 3002.5 | 143.5 | 71.8 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 634 | 3000 | 3000.0 | 88.4 | 88.4 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | False |
| 635 | 2998 | 2998.0 | 73.3 | 73.3 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | False |
| 636 | 2998 | 2998.0 | 65.7 | 65.7 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | False |
| 637 | 2993 | 2993.0 | 56.5 | 56.5 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 638 | 2988 | 2988.0 | 127.6 | 127.6 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 639 | 2985 | 2985.0 | 70.1 | 70.1 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | False |
| 640 | 2984 | 2984.0 | 70.0 | 70.0 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 641 | 2981 | 2981.0 | 68.0 | 68.0 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | False |
| 642 | 5960 | 2980.0 | 124.8 | 62.4 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 643 | 2979 | 2979.0 | 91.0 | 91.0 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | False |
| 644 | 2977 | 2977.0 | 56.7 | 56.7 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | False |
| 645 | 2975 | 2975.0 | 52.9 | 52.9 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 646 | 2969 | 2969.0 | 158.0 | 158.0 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | False |
| 647 | 2968 | 2968.0 | 90.0 | 90.0 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 648 | 5929 | 2964.5 | 179.9 | 90.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 649 | 2964 | 2964.0 | 57.3 | 57.3 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | False |
| 650 | 2956 | 2956.0 | 74.4 | 74.4 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 651 | 8861 | 2953.7 | 241.6 | 80.5 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 652 | 2952 | 2952.0 | 61.6 | 61.6 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | False |
| 653 | 8840 | 2946.7 | 194.8 | 64.9 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | False |
| 654 | 5889 | 2944.5 | 176.9 | 88.5 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | False |
| 655 | 2941 | 2941.0 | 44.3 | 44.3 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | False |
| 656 | 2938 | 2938.0 | 61.9 | 61.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | False |
| 657 | 5865 | 2932.5 | 125.9 | 63.0 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | False |
| 658 | 5860 | 2930.0 | 193.1 | 96.5 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 659 | 2929 | 2929.0 | 57.7 | 57.7 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 660 | 2923 | 2923.0 | 125.6 | 125.6 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | False |
| 661 | 5835 | 2917.5 | 197.7 | 98.8 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 662 | 2914 | 2914.0 | 86.6 | 86.6 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 663 | 2914 | 2914.0 | 52.4 | 52.4 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | False |
| 664 | 2912 | 2912.0 | 72.1 | 72.1 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | False |
| 665 | 2911 | 2911.0 | 59.9 | 59.9 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | False |
| 666 | 5820 | 2910.0 | 161.9 | 81.0 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | False |
| 667 | 8729 | 2909.7 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J HAVEL, H A EDER, J H BRAGDON | J Clin Invest | 1955 | 13252080 | Yes |
| 668 | 2909 | 2909.0 | 70.7 | 70.7 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 669 | 2908 | 2908.0 | 82.0 | 82.0 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | False |
| 670 | 2908 | 2908.0 | 75.8 | 75.8 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 671 | 2907 | 2907.0 | 73.4 | 73.4 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | False |
| 672 | 5809 | 2904.5 | 130.5 | 65.2 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | False |
| 673 | 2901 | 2901.0 | 130.3 | 130.3 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 674 | 2899 | 2899.0 | 48.6 | 48.6 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | False |
| 675 | 2897 | 2897.0 | 86.6 | 86.6 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | False |
| 676 | 5789 | 2894.5 | 249.3 | 124.7 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 677 | 2893 | 2893.0 | 0.0 | 0.0 | Notes on sugar determination. | M SMOGYI | J Biol Chem | 1952 | 14938350 | Yes |
| 678 | 5784 | 2892.0 | 169.3 | 84.7 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | False |
| 679 | 17349 | 2891.5 | 375.8 | 62.6 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 680 | 2890 | 2890.0 | 95.2 | 95.2 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | False |
| 681 | 2888 | 2888.0 | 50.0 | 50.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A GEHAN | Biometrika | 1965 | 14341275 | Yes |
| 682 | 2881 | 2881.0 | 90.7 | 90.7 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | False |
| 683 | 2879 | 2879.0 | 128.5 | 128.5 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 684 | 5754 | 2877.0 | 154.3 | 77.2 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | False |
| 685 | 2876 | 2876.0 | 67.9 | 67.9 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | False |
| 686 | 5747 | 2873.5 | 115.0 | 57.5 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 687 | 2872 | 2872.0 | 50.6 | 50.6 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 688 | 5732 | 2866.0 | 194.6 | 97.3 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 689 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C SCHNEIDER | J Biol Chem | 1945 | 21005736 | Yes |
| 690 | 2857 | 2857.0 | 60.5 | 60.5 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | False |
| 691 | 5714 | 2857.0 | 111.0 | 55.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | False |
| 692 | 2856 | 2856.0 | 82.6 | 82.6 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 693 | 5706 | 2853.0 | 161.3 | 80.7 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 694 | 8553 | 2851.0 | 246.9 | 82.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 695 | 5690 | 2845.0 | 172.1 | 86.0 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 696 | 2842 | 2842.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P AHLQUIST | Am J Physiol | 1948 | 18882199 | Yes |
| 697 | 2841 | 2841.0 | 76.4 | 76.4 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | False |
| 698 | 2838 | 2838.0 | 96.4 | 96.4 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 699 | 2838 | 2838.0 | 71.9 | 71.9 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | False |
| 700 | 5659 | 2829.5 | 203.2 | 101.6 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 701 | 2825 | 2825.0 | 94.2 | 94.2 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 702 | 5646 | 2823.0 | 158.9 | 79.5 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 703 | 2818 | 2818.0 | 110.5 | 110.5 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 704 | 5629 | 2814.5 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D WATSON, F H CRICK | Nature | 1953 | 13054692 | Yes |
| 705 | 2809 | 2809.0 | 83.4 | 83.4 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 706 | 2807 | 2807.0 | 63.7 | 63.7 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 707 | 2807 | 2807.0 | 65.3 | 65.3 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | False |
| 708 | 5612 | 2806.0 | 134.2 | 67.1 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | False |
| 709 | 5609 | 2804.5 | 152.0 | 76.0 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 710 | 5607 | 2803.5 | 132.3 | 66.2 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 711 | 5606 | 2803.0 | 125.7 | 62.9 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | False |
| 712 | 5604 | 2802.0 | 172.0 | 86.0 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 713 | 2801 | 2801.0 | 63.7 | 63.7 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | False |
| 714 | 8398 | 2799.3 | 221.1 | 73.7 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 715 | 5596 | 2798.0 | 315.0 | 157.5 | A modified uronic acid carbazole reaction. | T BITTER, H M MUIR | Anal Biochem | 1962 | 13971270 | Yes |
| 716 | 5589 | 2794.5 | 146.0 | 73.0 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 717 | 5580 | 2790.0 | 77.8 | 38.9 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G MARTIN, B N AMES | J Biol Chem | 1961 | 13767412 | Yes |
| 718 | 2785 | 2785.0 | 111.5 | 111.5 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 719 | 2785 | 2785.0 | 61.9 | 61.9 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | False |
| 720 | 2783 | 2783.0 | 56.0 | 56.0 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 721 | 11131 | 2782.8 | 294.8 | 73.7 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 722 | 2781 | 2781.0 | 87.9 | 87.9 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 723 | 2781 | 2781.0 | 52.9 | 52.9 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 724 | 2781 | 2781.0 | 91.2 | 91.2 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | False |
| 725 | 2777 | 2777.0 | 109.7 | 109.7 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 726 | 5552 | 2776.0 | 133.9 | 67.0 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | False |
| 727 | 2773 | 2773.0 | 24.1 | 24.1 | Satellite cell of skeletal muscle fibers. | A MAURO | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 728 | 2772 | 2772.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 729 | 5541 | 2770.5 | 167.0 | 83.5 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | False |
| 730 | 5526 | 2763.0 | 159.7 | 79.8 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 731 | 2763 | 2763.0 | 67.7 | 67.7 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | False |
| 732 | 2762 | 2762.0 | 61.6 | 61.6 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | False |
| 733 | 11047 | 2761.8 | 320.3 | 80.1 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 734 | 2757 | 2757.0 | 64.2 | 64.2 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 735 | 2756 | 2756.0 | 61.0 | 61.0 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 736 | 2754 | 2754.0 | 65.7 | 65.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | False |
| 737 | 2754 | 2754.0 | 60.9 | 60.9 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | False |
| 738 | 2754 | 2754.0 | 60.5 | 60.5 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | False |
| 739 | 2750 | 2750.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L SVENNERHOLM | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 740 | 5496 | 2748.0 | 176.8 | 88.4 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | False |
| 741 | 2742 | 2742.0 | 74.9 | 74.9 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 742 | 2738 | 2738.0 | 65.7 | 65.7 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | False |
| 743 | 5473 | 2736.5 | 107.7 | 53.9 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 744 | 8207 | 2735.7 | 209.9 | 70.0 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 745 | 10937 | 2734.2 | 256.1 | 64.0 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | False |
| 746 | 2732 | 2732.0 | 143.9 | 143.9 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 747 | 8187 | 2729.0 | 206.4 | 68.8 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | False |
| 748 | 2726 | 2726.0 | 97.5 | 97.5 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | False |
| 749 | 5450 | 2725.0 | 215.4 | 107.7 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 750 | 5450 | 2725.0 | 108.7 | 54.4 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J SILNESS, H LOE | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 751 | 2722 | 2722.0 | 64.2 | 64.2 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 752 | 5435 | 2717.5 | 109.6 | 54.8 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | False |
| 753 | 8147 | 2715.7 | 174.3 | 58.1 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 754 | 5403 | 2701.5 | 102.9 | 51.5 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | False |
| 755 | 10805 | 2701.2 | 226.5 | 56.6 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 756 | 2697 | 2697.0 | 73.7 | 73.7 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | False |
| 757 | 2696 | 2696.0 | 66.7 | 66.7 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 758 | 2695 | 2695.0 | 107.5 | 107.5 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | False |
| 759 | 2693 | 2693.0 | 82.8 | 82.8 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | False |
| 760 | 5380 | 2690.0 | 232.6 | 116.3 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 761 | 2687 | 2687.0 | 51.3 | 51.3 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | False |
| 762 | 2686 | 2686.0 | 54.7 | 54.7 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | False |
| 763 | 2686 | 2686.0 | 56.4 | 56.4 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | False |
| 764 | 5371 | 2685.5 | 135.8 | 67.9 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 765 | 2685 | 2685.0 | 57.9 | 57.9 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | False |
| 766 | 2685 | 2685.0 | 69.0 | 69.0 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | False |
| 767 | 5367 | 2683.5 | 123.0 | 61.5 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 768 | 8050 | 2683.3 | 193.7 | 64.6 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | False |
| 769 | 2683 | 2683.0 | 50.7 | 50.7 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | False |
| 770 | 5366 | 2683.0 | 118.6 | 59.3 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | False |
| 771 | 2678 | 2678.0 | 80.3 | 80.3 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | False |
| 772 | 8033 | 2677.7 | 324.5 | 108.2 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 773 | 8032 | 2677.3 | 195.4 | 65.1 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 774 | 5349 | 2674.5 | 140.7 | 70.3 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | False |
| 775 | 2669 | 2669.0 | 74.1 | 74.1 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 776 | 2669 | 2669.0 | 49.5 | 49.5 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | False |
| 777 | 2664 | 2664.0 | 61.7 | 61.7 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | False |
| 778 | 2662 | 2662.0 | 63.8 | 63.8 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | False |
| 779 | 2662 | 2662.0 | 107.6 | 107.6 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | False |
| 780 | 2660 | 2660.0 | 58.9 | 58.9 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 781 | 2657 | 2657.0 | 65.9 | 65.9 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | False |
| 782 | 5314 | 2657.0 | 171.3 | 85.7 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | False |
| 783 | 5312 | 2656.0 | 71.6 | 35.8 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 784 | 5312 | 2656.0 | 129.4 | 64.7 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 785 | 2650 | 2650.0 | 70.1 | 70.1 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | False |
| 786 | 2650 | 2650.0 | 76.6 | 76.6 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | False |
| 787 | 7948 | 2649.3 | 232.1 | 77.4 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 788 | 2649 | 2649.0 | 72.4 | 72.4 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 789 | 2645 | 2645.0 | 106.3 | 106.3 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 790 | 5290 | 2645.0 | 154.0 | 77.0 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 791 | 5279 | 2639.5 | 138.0 | 69.0 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 792 | 5273 | 2636.5 | 130.2 | 65.1 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 793 | 2631 | 2631.0 | 55.4 | 55.4 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | False |
| 794 | 2630 | 2630.0 | 55.4 | 55.4 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | False |
| 795 | 10486 | 2621.5 | 263.1 | 65.8 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 796 | 2619 | 2619.0 | 97.6 | 97.6 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 797 | 2618 | 2618.0 | 63.8 | 63.8 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | False |
| 798 | 5233 | 2616.5 | 116.4 | 58.2 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | False |
| 799 | 5233 | 2616.5 | 110.0 | 55.0 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 800 | 5231 | 2615.5 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O ARUNLAKSHANA, H O SCHILD | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 801 | 2612 | 2612.0 | 64.6 | 64.6 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | False |
| 802 | 5223 | 2611.5 | 180.4 | 90.2 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 803 | 5222 | 2611.0 | 160.6 | 80.3 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | False |
| 804 | 5220 | 2610.0 | 126.1 | 63.0 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | False |
| 805 | 2609 | 2609.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 806 | 2605 | 2605.0 | 79.7 | 79.7 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 807 | 2598 | 2598.0 | 85.7 | 85.7 | Working memory. | A Baddeley | Science | 1992 | 1736359 | False |
| 808 | 2597 | 2597.0 | 36.5 | 36.5 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | False |
| 809 | 41529 | 2595.6 | 1272.9 | 79.6 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 810 | 2594 | 2594.0 | 55.0 | 55.0 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | False |
| 811 | 2589 | 2589.0 | 80.4 | 80.4 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 812 | 2589 | 2589.0 | 92.7 | 92.7 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 813 | 5172 | 2586.0 | 102.0 | 51.0 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 814 | 2583 | 2583.0 | 115.1 | 115.1 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 815 | 2578 | 2578.0 | 120.5 | 120.5 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | False |
| 816 | 2574 | 2574.0 | 73.1 | 73.1 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 817 | 7717 | 2572.3 | 311.8 | 103.9 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 818 | 2571 | 2571.0 | 61.3 | 61.3 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | False |
| 819 | 2570 | 2570.0 | 56.0 | 56.0 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | False |
| 820 | 5140 | 2570.0 | 168.0 | 84.0 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 821 | 5139 | 2569.5 | 111.1 | 55.5 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | False |
| 822 | 7698 | 2566.0 | 214.7 | 71.6 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | False |
| 823 | 2565 | 2565.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R PORTER | Biochem J | 1959 | 14434282 | Yes |
| 824 | 5129 | 2564.5 | 163.1 | 81.5 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 825 | 2564 | 2564.0 | 74.7 | 74.7 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 826 | 2562 | 2562.0 | 81.0 | 81.0 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | False |
| 827 | 5110 | 2555.0 | 276.9 | 138.4 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 828 | 7665 | 2555.0 | 389.8 | 129.9 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 829 | 2552 | 2552.0 | 69.5 | 69.5 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | False |
| 830 | 5102 | 2551.0 | 218.5 | 109.2 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 831 | 2548 | 2548.0 | 125.9 | 125.9 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S BOYDEN | J Exp Med | 1962 | 13872176 | Yes |
| 832 | 2547 | 2547.0 | 103.3 | 103.3 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 833 | 2545 | 2545.0 | 50.8 | 50.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | False |
| 834 | 2545 | 2545.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O SMITHIES | Biochem J | 1955 | 13276348 | Yes |
| 835 | 5080 | 2540.0 | 138.5 | 69.2 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 836 | 2537 | 2537.0 | 60.8 | 60.8 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 837 | 2536 | 2536.0 | 105.5 | 105.5 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | False |
| 838 | 5071 | 2535.5 | 146.9 | 73.5 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 839 | 2534 | 2534.0 | 74.9 | 74.9 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | False |
| 840 | 2532 | 2532.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M FITTS | J Exp Psychol | 1954 | 13174710 | Yes |
| 841 | 5063 | 2531.5 | 121.6 | 60.8 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 842 | 5061 | 2530.5 | 143.3 | 71.7 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 843 | 2520 | 2520.0 | 67.3 | 67.3 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | False |
| 844 | 2517 | 2517.0 | 44.3 | 44.3 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | False |
| 845 | 2516 | 2516.0 | 76.9 | 76.9 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | False |
| 846 | 2516 | 2516.0 | 75.9 | 75.9 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
| 847 | 2516 | 2516.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 848 | 5027 | 2513.5 | 70.6 | 35.3 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H LOE, J SILNESS | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 849 | 5017 | 2508.5 | 96.1 | 48.0 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | False |
| 850 | 5014 | 2507.0 | 132.4 | 66.2 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | False |
| 851 | 2505 | 2505.0 | 70.2 | 70.2 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 852 | 5000 | 2500.0 | 148.1 | 74.0 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | False |
| 853 | 2499 | 2499.0 | 57.3 | 57.3 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | False |
| 854 | 4989 | 2494.5 | 146.4 | 73.2 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 855 | 2494 | 2494.0 | 79.3 | 79.3 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 856 | 2494 | 2494.0 | 67.7 | 67.7 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | False |
| 857 | 4985 | 2492.5 | 180.9 | 90.5 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 858 | 9955 | 2488.8 | 210.6 | 52.6 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 859 | 2487 | 2487.0 | 82.0 | 82.0 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 860 | 4974 | 2487.0 | 161.2 | 80.6 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 861 | 2487 | 2487.0 | 163.1 | 163.1 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | False |
| 862 | 2483 | 2483.0 | 50.7 | 50.7 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | False |
| 863 | 2478 | 2478.0 | 44.2 | 44.2 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | False |
| 864 | 4954 | 2477.0 | 129.7 | 64.8 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | False |
| 865 | 4952 | 2476.0 | 129.0 | 64.5 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 866 | 2473 | 2473.0 | 112.1 | 112.1 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 867 | 2473 | 2473.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S LENNOX | Virology | 1955 | 13267987 | Yes |
| 868 | 7414 | 2471.3 | 194.6 | 64.9 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
| 869 | 2471 | 2471.0 | 62.1 | 62.1 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | False |
| 870 | 2470 | 2470.0 | 69.5 | 69.5 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | False |
| 871 | 2470 | 2470.0 | 52.2 | 52.2 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | False |
| 872 | 4938 | 2469.0 | 93.7 | 46.9 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | False |
| 873 | 2469 | 2469.0 | 43.9 | 43.9 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 874 | 4934 | 2467.0 | 160.7 | 80.3 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 875 | 2467 | 2467.0 | 130.2 | 130.2 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | False |
| 876 | 2464 | 2464.0 | 60.7 | 60.7 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | False |
| 877 | 2461 | 2461.0 | 76.3 | 76.3 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | False |
| 878 | 2459 | 2459.0 | 94.8 | 94.8 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 879 | 2458 | 2458.0 | 52.2 | 52.2 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | False |
| 880 | 2458 | 2458.0 | 62.3 | 62.3 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | False |
| 881 | 2457 | 2457.0 | 47.3 | 47.3 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 882 | 4912 | 2456.0 | 94.9 | 47.5 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | False |
| 883 | 2451 | 2451.0 | 53.0 | 53.0 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | False |
| 884 | 7349 | 2449.7 | 156.0 | 52.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | False |
| 885 | 4896 | 2448.0 | 117.9 | 59.0 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 886 | 4893 | 2446.5 | 105.0 | 52.5 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | False |
| 887 | 2445 | 2445.0 | 53.9 | 53.9 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | False |
| 888 | 2445 | 2445.0 | 65.1 | 65.1 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 889 | 4887 | 2443.5 | 120.4 | 60.2 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | False |
| 890 | 9763 | 2440.8 | 209.6 | 52.4 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 891 | 2440 | 2440.0 | 59.0 | 59.0 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | False |
| 892 | 2439 | 2439.0 | 28.3 | 28.3 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T HIGUCHI | J Pharm Sci | 1963 | 14088963 | Yes |
| 893 | 12176 | 2435.2 | 276.4 | 55.3 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 894 | 2433 | 2433.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G BERTANI | J Bacteriol | 1951 | 14888646 | Yes |
| 895 | 2431 | 2431.0 | 69.9 | 69.9 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | False |
| 896 | 9710 | 2427.5 | 193.0 | 48.2 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 897 | 2427 | 2427.0 | 58.3 | 58.3 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | False |
| 898 | 2426 | 2426.0 | 78.1 | 78.1 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | False |
| 899 | 4838 | 2419.0 | 131.4 | 65.7 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | False |
| 900 | 2417 | 2417.0 | 61.7 | 61.7 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | False |
| 901 | 2417 | 2417.0 | 129.1 | 129.1 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | False |
| 902 | 4832 | 2416.0 | 174.7 | 87.3 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | False |
| 903 | 4832 | 2416.0 | 105.3 | 52.6 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | False |
| 904 | 2414 | 2414.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F HUXLEY | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 905 | 2413 | 2413.0 | 51.9 | 51.9 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | False |
| 906 | 2412 | 2412.0 | 54.7 | 54.7 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | False |
| 907 | 2411 | 2411.0 | 63.6 | 63.6 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | False |
| 908 | 2410 | 2410.0 | 61.6 | 61.6 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | False |
| 909 | 2410 | 2410.0 | 67.4 | 67.4 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 910 | 2405 | 2405.0 | 74.0 | 74.0 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 911 | 2405 | 2405.0 | 59.2 | 59.2 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | False |
| 912 | 2404 | 2404.0 | 62.0 | 62.0 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 913 | 2403 | 2403.0 | 49.0 | 49.0 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | False |
| 914 | 4805 | 2402.5 | 109.0 | 54.5 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | False |
| 915 | 4801 | 2400.5 | 126.8 | 63.4 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 916 | 2400 | 2400.0 | 62.6 | 62.6 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 917 | 4798 | 2399.0 | 97.3 | 48.6 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | False |
| 918 | 7181 | 2393.7 | 219.5 | 73.2 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 919 | 2392 | 2392.0 | 55.2 | 55.2 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | False |
| 920 | 4784 | 2392.0 | 91.0 | 45.5 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | False |
| 921 | 2391 | 2391.0 | 80.5 | 80.5 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
| 922 | 2391 | 2391.0 | 57.2 | 57.2 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | False |
| 923 | 4781 | 2390.5 | 118.3 | 59.1 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | False |
| 924 | 2390 | 2390.0 | 49.3 | 49.3 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | False |
| 925 | 4777 | 2388.5 | 134.0 | 67.0 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | False |
| 926 | 7165 | 2388.3 | 70.7 | 23.6 | On The Nature Of Allosteric Transitions: A Plausible Model. | J MONOD, J WYMAN, J P CHANGEUX | J Mol Biol | 1965 | 14343300 | Yes |
| 927 | 2388 | 2388.0 | 127.4 | 127.4 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 928 | 4774 | 2387.0 | 111.2 | 55.6 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | False |
| 929 | 4772 | 2386.0 | 174.0 | 87.0 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | False |
| 930 | 4771 | 2385.5 | 124.5 | 62.2 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 931 | 4768 | 2384.0 | 135.2 | 67.6 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | False |
| 932 | 2375 | 2375.0 | 55.9 | 55.9 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | False |
| 933 | 2374 | 2374.0 | 73.8 | 73.8 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | False |
| 934 | 2373 | 2373.0 | 98.1 | 98.1 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 935 | 4740 | 2370.0 | 88.8 | 44.4 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 936 | 4740 | 2370.0 | 103.0 | 51.5 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | False |
| 937 | 2365 | 2365.0 | 79.8 | 79.8 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 938 | 2360 | 2360.0 | 141.1 | 141.1 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 939 | 4717 | 2358.5 | 118.3 | 59.1 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 940 | 7067 | 2355.7 | 192.3 | 64.1 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | False |
| 941 | 4708 | 2354.0 | 96.2 | 48.1 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | False |
| 942 | 2353 | 2353.0 | 125.7 | 125.7 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 943 | 2349 | 2349.0 | 39.8 | 39.8 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 944 | 7047 | 2349.0 | 201.9 | 67.3 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | False |
| 945 | 9391 | 2347.8 | 439.7 | 109.9 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 946 | 2347 | 2347.0 | 57.9 | 57.9 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | False |
| 947 | 2346 | 2346.0 | 47.4 | 47.4 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 948 | 2344 | 2344.0 | 51.9 | 51.9 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | False |
| 949 | 2341 | 2341.0 | 65.7 | 65.7 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | False |
| 950 | 4681 | 2340.5 | 77.2 | 38.6 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 951 | 2337 | 2337.0 | 45.1 | 45.1 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | False |
| 952 | 2336 | 2336.0 | 56.0 | 56.0 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | False |
| 953 | 4670 | 2335.0 | 102.8 | 51.4 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 954 | 4670 | 2335.0 | 87.8 | 43.9 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 955 | 2333 | 2333.0 | 91.0 | 91.0 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 956 | 2331 | 2331.0 | 84.2 | 84.2 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | False |
| 957 | 2331 | 2331.0 | 42.6 | 42.6 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | False |
| 958 | 2328 | 2328.0 | 43.0 | 43.0 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | False |
| 959 | 9301 | 2325.2 | 215.9 | 54.0 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 960 | 4646 | 2323.0 | 115.1 | 57.5 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | False |
| 961 | 2322 | 2322.0 | 65.5 | 65.5 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | False |
| 962 | 4642 | 2321.0 | 168.2 | 84.1 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | False |
| 963 | 2320 | 2320.0 | 69.0 | 69.0 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | False |
| 964 | 18557 | 2319.6 | 722.6 | 90.3 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 965 | 4636 | 2318.0 | 130.1 | 65.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 966 | 2315 | 2315.0 | 71.8 | 71.8 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | False |
| 967 | 2313 | 2313.0 | 71.5 | 71.5 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | False |
| 968 | 6934 | 2311.3 | 277.2 | 92.4 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | False |
| 969 | 4621 | 2310.5 | 115.4 | 57.7 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | False |
| 970 | 2306 | 2306.0 | 85.5 | 85.5 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 971 | 2305 | 2305.0 | 52.7 | 52.7 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 972 | 4608 | 2304.0 | 134.6 | 67.3 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 973 | 4605 | 2302.5 | 69.1 | 34.5 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 974 | 2302 | 2302.0 | 56.6 | 56.6 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | False |
| 975 | 2302 | 2302.0 | 56.4 | 56.4 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | False |
| 976 | 2300 | 2300.0 | 61.5 | 61.5 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 977 | 2299 | 2299.0 | 56.7 | 56.7 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | False |
| 978 | 4590 | 2295.0 | 190.0 | 95.0 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | False |
| 979 | 4589 | 2294.5 | 109.4 | 54.7 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 980 | 4588 | 2294.0 | 76.1 | 38.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 981 | 6882 | 2294.0 | 203.0 | 67.7 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 982 | 4587 | 2293.5 | 90.6 | 45.3 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 983 | 4580 | 2290.0 | 115.8 | 57.9 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | False |
| 984 | 2287 | 2287.0 | 49.4 | 49.4 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 985 | 4571 | 2285.5 | 109.0 | 54.5 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | False |
| 986 | 2283 | 2283.0 | 49.4 | 49.4 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | False |
| 987 | 6846 | 2282.0 | 264.7 | 88.2 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 988 | 2282 | 2282.0 | 75.8 | 75.8 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | False |
| 989 | 2282 | 2282.0 | 45.2 | 45.2 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 990 | 2279 | 2279.0 | 69.0 | 69.0 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | False |
| 991 | 2279 | 2279.0 | 47.8 | 47.8 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | False |
| 992 | 6831 | 2277.0 | 137.5 | 45.8 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 993 | 2270 | 2270.0 | 91.2 | 91.2 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | False |
| 994 | 2269 | 2269.0 | 47.4 | 47.4 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | False |
| 995 | 2268 | 2268.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A CLAUSS | Acta Haematol | 1957 | 13434757 | Yes |
| 996 | 2266 | 2266.0 | 60.6 | 60.6 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 997 | 4531 | 2265.5 | 150.0 | 75.0 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | False |
| 998 | 2263 | 2263.0 | 68.1 | 68.1 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | False |
| 999 | 4524 | 2262.0 | 188.3 | 94.2 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1000 | 4524 | 2262.0 | 89.3 | 44.6 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 1001 | 2262 | 2262.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H PENNES | J Appl Physiol | 1948 | 18887578 | Yes |
| 1002 | 2261 | 2261.0 | 138.6 | 138.6 | Application of a microtechnique to viral serological investigations. | J L SEVER | J Immunol | 1962 | 13910995 | Yes |
| 1003 | 4517 | 2258.5 | 110.6 | 55.3 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | False |
| 1004 | 2256 | 2256.0 | 56.2 | 56.2 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | False |
| 1005 | 4509 | 2254.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B SCOVILLE, B MILNER | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1006 | 2252 | 2252.0 | 53.0 | 53.0 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | False |
| 1007 | 2252 | 2252.0 | 54.7 | 54.7 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1008 | 2251 | 2251.0 | 53.8 | 53.8 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | False |
| 1009 | 4502 | 2251.0 | 39.2 | 19.6 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 1010 | 2250 | 2250.0 | 48.2 | 48.2 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | False |
| 1011 | 2250 | 2250.0 | 51.3 | 51.3 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | False |
| 1012 | 6750 | 2250.0 | 155.0 | 51.7 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1013 | 2249 | 2249.0 | 67.9 | 67.9 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 1014 | 4497 | 2248.5 | 102.4 | 51.2 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 1015 | 4497 | 2248.5 | 128.6 | 64.3 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 1016 | 2248 | 2248.0 | 50.0 | 50.0 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | False |
| 1017 | 4495 | 2247.5 | 86.4 | 43.2 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | False |
| 1018 | 4494 | 2247.0 | 83.4 | 41.7 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1019 | 2245 | 2245.0 | 60.9 | 60.9 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | False |
| 1020 | 2243 | 2243.0 | 60.0 | 60.0 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1021 | 2242 | 2242.0 | 115.7 | 115.7 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 1022 | 2242 | 2242.0 | 54.8 | 54.8 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 1023 | 2242 | 2242.0 | 89.6 | 89.6 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | False |
| 1024 | 2239 | 2239.0 | 76.6 | 76.6 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | False |
| 1025 | 2238 | 2238.0 | 65.8 | 65.8 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | False |
| 1026 | 4475 | 2237.5 | 163.8 | 81.9 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | False |
| 1027 | 2236 | 2236.0 | 57.6 | 57.6 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | False |
| 1028 | 2236 | 2236.0 | 55.9 | 55.9 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | False |
| 1029 | 4472 | 2236.0 | 103.1 | 51.5 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | False |
| 1030 | 2234 | 2234.0 | 61.2 | 61.2 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | False |
| 1031 | 2234 | 2234.0 | 48.9 | 48.9 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | False |
| 1032 | 2234 | 2234.0 | 52.7 | 52.7 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | False |
| 1033 | 2233 | 2233.0 | 64.7 | 64.7 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 1034 | 4465 | 2232.5 | 120.9 | 60.5 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | False |
| 1035 | 2232 | 2232.0 | 49.3 | 49.3 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | False |
| 1036 | 2232 | 2232.0 | 65.7 | 65.7 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 1037 | 2230 | 2230.0 | 111.5 | 111.5 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | False |
| 1038 | 4460 | 2230.0 | 99.0 | 49.5 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | False |
| 1039 | 4448 | 2224.0 | 98.0 | 49.0 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | False |
| 1040 | 2224 | 2224.0 | 52.2 | 52.2 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | False |
| 1041 | 2224 | 2224.0 | 52.3 | 52.3 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1042 | 2224 | 2224.0 | 48.1 | 48.1 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | False |
| 1043 | 4443 | 2221.5 | 139.9 | 70.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 1044 | 2221 | 2221.0 | 95.0 | 95.0 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1045 | 13318 | 2219.7 | 294.7 | 49.1 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1046 | 24402 | 2218.4 | 590.3 | 53.7 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1047 | 4433 | 2216.5 | 139.2 | 69.6 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
| 1048 | 4426 | 2213.0 | 125.8 | 62.9 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | False |
| 1049 | 2210 | 2210.0 | 72.2 | 72.2 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1050 | 4419 | 2209.5 | 158.6 | 79.3 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | False |
| 1051 | 2206 | 2206.0 | 67.6 | 67.6 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | False |
| 1052 | 2206 | 2206.0 | 91.3 | 91.3 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1053 | 2205 | 2205.0 | 56.4 | 56.4 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 1054 | 2204 | 2204.0 | 109.7 | 109.7 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | False |
| 1055 | 2204 | 2204.0 | 48.4 | 48.4 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | False |
| 1056 | 2203 | 2203.0 | 83.8 | 83.8 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | False |
| 1057 | 2203 | 2203.0 | 78.9 | 78.9 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1058 | 2201 | 2201.0 | 39.8 | 39.8 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | False |
| 1059 | 2201 | 2201.0 | 62.3 | 62.3 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | False |
| 1060 | 2199 | 2199.0 | 76.0 | 76.0 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | False |
| 1061 | 2197 | 2197.0 | 72.6 | 72.6 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | False |
| 1062 | 6591 | 2197.0 | 237.7 | 79.2 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 1063 | 2194 | 2194.0 | 76.4 | 76.4 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | False |
| 1064 | 4387 | 2193.5 | 94.3 | 47.1 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 1065 | 4385 | 2192.5 | 83.6 | 41.8 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | False |
| 1066 | 2191 | 2191.0 | 97.7 | 97.7 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | False |
| 1067 | 6560 | 2186.7 | 165.8 | 55.3 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1068 | 6556 | 2185.3 | 188.9 | 63.0 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1069 | 4370 | 2185.0 | 148.2 | 74.1 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1070 | 8729 | 2182.2 | 339.2 | 84.8 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1071 | 2181 | 2181.0 | 53.4 | 53.4 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | False |
| 1072 | 2181 | 2181.0 | 63.5 | 63.5 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | False |
| 1073 | 4359 | 2179.5 | 93.0 | 46.5 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | False |
| 1074 | 4358 | 2179.0 | 93.6 | 46.8 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1075 | 4358 | 2179.0 | 80.4 | 40.2 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | False |
| 1076 | 2179 | 2179.0 | 44.3 | 44.3 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | False |
| 1077 | 4349 | 2174.5 | 193.5 | 96.8 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | False |
| 1078 | 2174 | 2174.0 | 58.6 | 58.6 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1079 | 6522 | 2174.0 | 118.7 | 39.6 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1080 | 2172 | 2172.0 | 48.6 | 48.6 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | False |
| 1081 | 2166 | 2166.0 | 41.6 | 41.6 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | False |
| 1082 | 2165 | 2165.0 | 64.8 | 64.8 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1083 | 6493 | 2164.3 | 177.7 | 59.2 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1084 | 2162 | 2162.0 | 46.1 | 46.1 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | False |
| 1085 | 2162 | 2162.0 | 51.0 | 51.0 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | False |
| 1086 | 2160 | 2160.0 | 49.6 | 49.6 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | False |
| 1087 | 4319 | 2159.5 | 133.4 | 66.7 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | False |
| 1088 | 8631 | 2157.8 | 280.8 | 70.2 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1089 | 4313 | 2156.5 | 100.9 | 50.5 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | False |
| 1090 | 4313 | 2156.5 | 151.5 | 75.8 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1091 | 2154 | 2154.0 | 50.9 | 50.9 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | False |
| 1092 | 4304 | 2152.0 | 102.9 | 51.5 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1093 | 2152 | 2152.0 | 31.2 | 31.2 | Sedimentation Studies Of The Size And Shape Of Dna. | F W STUDIER | J Mol Biol | 1965 | 14290352 | Yes |
| 1094 | 2149 | 2149.0 | 84.3 | 84.3 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1095 | 2149 | 2149.0 | 51.1 | 51.1 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1096 | 4294 | 2147.0 | 189.1 | 94.5 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1097 | 4293 | 2146.5 | 106.7 | 53.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | False |
| 1098 | 2146 | 2146.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z DISCHE | J Biol Chem | 1947 | 20281638 | Yes |
| 1099 | 2145 | 2145.0 | 42.7 | 42.7 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | False |
| 1100 | 8579 | 2144.8 | 275.2 | 68.8 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | False |
| 1101 | 4289 | 2144.5 | 82.1 | 41.0 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | False |
| 1102 | 2144 | 2144.0 | 77.8 | 77.8 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | False |
| 1103 | 4288 | 2144.0 | 234.3 | 117.2 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 1104 | 4285 | 2142.5 | 72.9 | 36.5 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H VENABLE, R COGGESHALL | J Cell Biol | 1965 | 14287192 | Yes |
| 1105 | 6422 | 2140.7 | 146.0 | 48.7 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1106 | 2140 | 2140.0 | 42.5 | 42.5 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | False |
| 1107 | 2140 | 2140.0 | 41.4 | 41.4 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | False |
| 1108 | 2138 | 2138.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O WARBURG | Science | 1956 | 13351639 | Yes |
| 1109 | 2138 | 2138.0 | 59.8 | 59.8 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 1110 | 2138 | 2138.0 | 67.3 | 67.3 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | False |
| 1111 | 2137 | 2137.0 | 58.5 | 58.5 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | False |
| 1112 | 8547 | 2136.8 | 200.4 | 50.1 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | False |
| 1113 | 2135 | 2135.0 | 64.3 | 64.3 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1114 | 2134 | 2134.0 | 40.4 | 40.4 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | False |
| 1115 | 4267 | 2133.5 | 182.2 | 91.1 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1116 | 6400 | 2133.3 | 271.4 | 90.5 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1117 | 6400 | 2133.3 | 131.1 | 43.7 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1118 | 2132 | 2132.0 | 49.6 | 49.6 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | False |
| 1119 | 4261 | 2130.5 | 121.6 | 60.8 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | False |
| 1120 | 4261 | 2130.5 | 103.8 | 51.9 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | False |
| 1121 | 4260 | 2130.0 | 93.9 | 47.0 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | False |
| 1122 | 6389 | 2129.7 | 203.8 | 67.9 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1123 | 4259 | 2129.5 | 119.2 | 59.6 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 1124 | 8510 | 2127.5 | 202.3 | 50.6 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1125 | 2127 | 2127.0 | 65.8 | 65.8 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | False |
| 1126 | 4252 | 2126.0 | 36.1 | 18.1 | Genetic regulatory mechanisms in the synthesis of proteins. | F JACOB, J MONOD | J Mol Biol | 1961 | 13718526 | Yes |
| 1127 | 4251 | 2125.5 | 121.7 | 60.9 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | False |
| 1128 | 4250 | 2125.0 | 110.4 | 55.2 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | False |
| 1129 | 4250 | 2125.0 | 97.6 | 48.8 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | False |
| 1130 | 2125 | 2125.0 | 64.7 | 64.7 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | False |
| 1131 | 2124 | 2124.0 | 44.1 | 44.1 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | False |
| 1132 | 2121 | 2121.0 | 41.8 | 41.8 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | False |
| 1133 | 4242 | 2121.0 | 116.6 | 58.3 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 1134 | 4239 | 2119.5 | 114.4 | 57.2 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | False |
| 1135 | 2118 | 2118.0 | 35.0 | 35.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D AMINOFF | Biochem J | 1961 | 13860975 | Yes |
| 1136 | 2118 | 2118.0 | 92.4 | 92.4 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | False |
| 1137 | 4230 | 2115.0 | 82.4 | 41.2 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | False |
| 1138 | 4229 | 2114.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F BEERS, I W SIZER | J Biol Chem | 1952 | 14938361 | Yes |
| 1139 | 2113 | 2113.0 | 42.8 | 42.8 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | False |
| 1140 | 8450 | 2112.5 | 313.7 | 78.4 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
| 1141 | 2112 | 2112.0 | 83.6 | 83.6 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | False |
| 1142 | 2110 | 2110.0 | 60.4 | 60.4 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | False |
| 1143 | 2110 | 2110.0 | 43.6 | 43.6 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | False |
| 1144 | 2108 | 2108.0 | 40.8 | 40.8 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | False |
| 1145 | 6322 | 2107.3 | 204.9 | 68.3 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | False |
| 1146 | 2107 | 2107.0 | 49.2 | 49.2 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1147 | 2107 | 2107.0 | 54.2 | 54.2 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | False |
| 1148 | 4213 | 2106.5 | 106.0 | 53.0 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1149 | 4213 | 2106.5 | 162.0 | 81.0 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 1150 | 4210 | 2105.0 | 82.2 | 41.1 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1151 | 6312 | 2104.0 | 183.0 | 61.0 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1152 | 2100 | 2100.0 | 50.0 | 50.0 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1153 | 2097 | 2097.0 | 66.5 | 66.5 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
| 1154 | 4191 | 2095.5 | 122.0 | 61.0 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1155 | 14668 | 2095.4 | 318.0 | 45.4 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1156 | 2095 | 2095.0 | 44.3 | 44.3 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | False |
| 1157 | 4189 | 2094.5 | 167.6 | 83.8 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | False |
| 1158 | 2094 | 2094.0 | 65.0 | 65.0 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | False |
| 1159 | 2091 | 2091.0 | 98.8 | 98.8 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1160 | 6269 | 2089.7 | 202.6 | 67.5 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | False |
| 1161 | 16697 | 2087.1 | 470.6 | 58.8 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1162 | 4174 | 2087.0 | 80.5 | 40.2 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | False |
| 1163 | 2085 | 2085.0 | 39.9 | 39.9 | Method For Assay Of Intestinal Disaccharidases. | A DAHLQVIST | Anal Biochem | 1964 | 14106916 | Yes |
| 1164 | 2084 | 2084.0 | 57.8 | 57.8 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | False |
| 1165 | 2084 | 2084.0 | 68.0 | 68.0 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | False |
| 1166 | 2082 | 2082.0 | 56.7 | 56.7 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | False |
| 1167 | 2081 | 2081.0 | 47.1 | 47.1 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | False |
| 1168 | 8323 | 2080.8 | 267.8 | 67.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1169 | 2079 | 2079.0 | 40.3 | 40.3 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | False |
| 1170 | 2078 | 2078.0 | 59.3 | 59.3 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1171 | 2077 | 2077.0 | 52.5 | 52.5 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | False |
| 1172 | 4154 | 2077.0 | 132.8 | 66.4 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | False |
| 1173 | 10384 | 2076.8 | 326.2 | 65.2 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | False |
| 1174 | 2075 | 2075.0 | 46.8 | 46.8 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | False |
| 1175 | 4149 | 2074.5 | 116.2 | 58.1 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | False |
| 1176 | 2074 | 2074.0 | 39.4 | 39.4 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | False |
| 1177 | 2073 | 2073.0 | 73.7 | 73.7 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1178 | 4145 | 2072.5 | 99.2 | 49.6 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1179 | 14503 | 2071.9 | 321.3 | 45.9 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1180 | 4143 | 2071.5 | 110.6 | 55.3 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | False |
| 1181 | 2070 | 2070.0 | 48.9 | 48.9 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1182 | 2069 | 2069.0 | 40.0 | 40.0 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | False |
| 1183 | 4138 | 2069.0 | 149.0 | 74.5 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | False |
| 1184 | 2069 | 2069.0 | 37.4 | 37.4 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C SKOU | Physiol Rev | 1965 | 14337569 | False |
| 1185 | 4137 | 2068.5 | 156.5 | 78.2 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | False |
| 1186 | 2067 | 2067.0 | 42.4 | 42.4 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | False |
| 1187 | 2067 | 2067.0 | 50.0 | 50.0 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | False |
| 1188 | 2067 | 2067.0 | 42.2 | 42.2 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | False |
| 1189 | 2067 | 2067.0 | 38.6 | 38.6 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | False |
| 1190 | 2067 | 2067.0 | 79.8 | 79.8 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | False |
| 1191 | 16522 | 2065.2 | 391.4 | 48.9 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1192 | 2065 | 2065.0 | 64.1 | 64.1 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | False |
| 1193 | 2063 | 2063.0 | 70.7 | 70.7 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | False |
| 1194 | 2063 | 2063.0 | 39.0 | 39.0 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | False |
| 1195 | 4122 | 2061.0 | 82.8 | 41.4 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | False |
| 1196 | 4120 | 2060.0 | 85.7 | 42.9 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1197 | 2060 | 2060.0 | 18.6 | 18.6 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W CLELAND | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1198 | 4118 | 2059.0 | 118.2 | 59.1 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | False |
| 1199 | 4117 | 2058.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R DULBECCO, M VOGT | J Exp Med | 1954 | 13130792 | Yes |
| 1200 | 2056 | 2056.0 | 51.7 | 51.7 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | False |
| 1201 | 2056 | 2056.0 | 63.3 | 63.3 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | False |
| 1202 | 4111 | 2055.5 | 95.5 | 47.8 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1203 | 2055 | 2055.0 | 64.2 | 64.2 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1204 | 2055 | 2055.0 | 43.2 | 43.2 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | False |
| 1205 | 6156 | 2052.0 | 228.8 | 76.3 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1206 | 2052 | 2052.0 | 23.8 | 23.8 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W LITTLEFIELD | Science | 1964 | 14168277 | Yes |
| 1207 | 12307 | 2051.2 | 364.6 | 60.8 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
| 1208 | 2051 | 2051.0 | 47.3 | 47.3 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | False |
| 1209 | 2050 | 2050.0 | 84.3 | 84.3 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1210 | 6150 | 2050.0 | 202.8 | 67.6 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 1211 | 4096 | 2048.0 | 230.6 | 115.3 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1212 | 6142 | 2047.3 | 197.2 | 65.7 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | False |
| 1213 | 2047 | 2047.0 | 46.8 | 46.8 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1214 | 4091 | 2045.5 | 226.8 | 113.4 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 1215 | 2045 | 2045.0 | 100.6 | 100.6 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V NEEL | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1216 | 2045 | 2045.0 | 77.3 | 77.3 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | False |
| 1217 | 4086 | 2043.0 | 145.3 | 72.7 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | False |
| 1218 | 2043 | 2043.0 | 34.6 | 34.6 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | False |
| 1219 | 2039 | 2039.0 | 58.6 | 58.6 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | False |
| 1220 | 2039 | 2039.0 | 67.3 | 67.3 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1221 | 4076 | 2038.0 | 140.1 | 70.0 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | False |
| 1222 | 2036 | 2036.0 | 51.2 | 51.2 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | False |
| 1223 | 2036 | 2036.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C TOLMAN | Psychol Rev | 1948 | 18870876 | Yes |
| 1224 | 2034 | 2034.0 | 72.0 | 72.0 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | False |
| 1225 | 14225 | 2032.1 | 406.0 | 58.0 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1226 | 2032 | 2032.0 | 45.8 | 45.8 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | False |
| 1227 | 4064 | 2032.0 | 88.3 | 44.1 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | False |
| 1228 | 4063 | 2031.5 | 97.9 | 49.0 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1229 | 4063 | 2031.5 | 92.3 | 46.1 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1230 | 4062 | 2031.0 | 110.2 | 55.1 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1231 | 2030 | 2030.0 | 47.2 | 47.2 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | False |
| 1232 | 4060 | 2030.0 | 152.8 | 76.4 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | False |
| 1233 | 4059 | 2029.5 | 142.8 | 71.4 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1234 | 2029 | 2029.0 | 46.4 | 46.4 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | False |
| 1235 | 4057 | 2028.5 | 89.9 | 45.0 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | False |
| 1236 | 4054 | 2027.0 | 124.7 | 62.4 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1237 | 4053 | 2026.5 | 137.0 | 68.5 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | Yes |
| 1238 | 2025 | 2025.0 | 34.6 | 34.6 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | False |
| 1239 | 2024 | 2024.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A SHOLL | J Anat | 1953 | 13117757 | Yes |
| 1240 | 2024 | 2024.0 | 60.0 | 60.0 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | False |
| 1241 | 2024 | 2024.0 | 64.4 | 64.4 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | False |
| 1242 | 2022 | 2022.0 | 52.6 | 52.6 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1243 | 4044 | 2022.0 | 101.7 | 50.9 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1244 | 2022 | 2022.0 | 56.8 | 56.8 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | False |
| 1245 | 2021 | 2021.0 | 36.8 | 36.8 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1246 | 2020 | 2020.0 | 50.5 | 50.5 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1247 | 2020 | 2020.0 | 58.4 | 58.4 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1248 | 4038 | 2019.0 | 138.4 | 69.2 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1249 | 4037 | 2018.5 | 109.4 | 54.7 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | False |
| 1250 | 2017 | 2017.0 | 62.8 | 62.8 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1251 | 2015 | 2015.0 | 51.6 | 51.6 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | False |
| 1252 | 2013 | 2013.0 | 88.2 | 88.2 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1253 | 2013 | 2013.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1254 | 4024 | 2012.0 | 98.4 | 49.2 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | False |
| 1255 | 2012 | 2012.0 | 55.0 | 55.0 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1256 | 2010 | 2010.0 | 41.1 | 41.1 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1257 | 4019 | 2009.5 | 174.7 | 87.3 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | False |
| 1258 | 8036 | 2009.0 | 220.7 | 55.2 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1259 | 2008 | 2008.0 | 41.4 | 41.4 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | False |
| 1260 | 2007 | 2007.0 | 39.0 | 39.0 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | False |
| 1261 | 4013 | 2006.5 | 85.5 | 42.8 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | False |
| 1262 | 2005 | 2005.0 | 38.0 | 38.0 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | False |
| 1263 | 2004 | 2004.0 | 45.4 | 45.4 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1264 | 4007 | 2003.5 | 124.4 | 62.2 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | False |
| 1265 | 2003 | 2003.0 | 54.8 | 54.8 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | False |
| 1266 | 2003 | 2003.0 | 83.4 | 83.4 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1267 | 2002 | 2002.0 | 43.4 | 43.4 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | False |
| 1268 | 2001 | 2001.0 | 43.5 | 43.5 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1269 | 2000 | 2000.0 | 42.6 | 42.6 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1270 | 5999 | 1999.7 | 203.9 | 68.0 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1271 | 3999 | 1999.5 | 98.2 | 49.1 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | False |
| 1272 | 3996 | 1998.0 | 86.3 | 43.1 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1273 | 3996 | 1998.0 | 77.5 | 38.8 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
| 1274 | 1998 | 1998.0 | 52.3 | 52.3 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | False |
| 1275 | 5990 | 1996.7 | 107.4 | 35.8 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1276 | 1996 | 1996.0 | 50.3 | 50.3 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | False |
| 1277 | 3988 | 1994.0 | 85.6 | 42.8 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1278 | 7974 | 1993.5 | 186.8 | 46.7 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | False |
| 1279 | 3985 | 1992.5 | 121.3 | 60.6 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1280 | 3984 | 1992.0 | 108.0 | 54.0 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | False |
| 1281 | 1991 | 1991.0 | 43.8 | 43.8 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1282 | 1991 | 1991.0 | 34.6 | 34.6 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | False |
| 1283 | 1990 | 1990.0 | 52.6 | 52.6 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | False |
| 1284 | 1989 | 1989.0 | 40.3 | 40.3 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | False |
| 1285 | 1988 | 1988.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1286 | 1987 | 1987.0 | 39.7 | 39.7 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | False |
| 1287 | 1987 | 1987.0 | 43.4 | 43.4 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | False |
| 1288 | 3972 | 1986.0 | 95.9 | 48.0 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1289 | 1986 | 1986.0 | 76.1 | 76.1 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1290 | 1986 | 1986.0 | 22.6 | 22.6 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1291 | 1985 | 1985.0 | 54.7 | 54.7 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | False |
| 1292 | 3964 | 1982.0 | 89.5 | 44.8 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1293 | 3962 | 1981.0 | 96.5 | 48.2 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | False |
| 1294 | 3960 | 1980.0 | 59.7 | 29.9 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R MORRISON, L M SMITH | J Lipid Res | 1964 | 14221106 | Yes |
| 1295 | 3957 | 1978.5 | 155.9 | 78.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1296 | 1978 | 1978.0 | 58.9 | 58.9 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | False |
| 1297 | 1976 | 1976.0 | 39.8 | 39.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | False |
| 1298 | 1975 | 1975.0 | 39.2 | 39.2 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | False |
| 1299 | 1974 | 1974.0 | 51.4 | 51.4 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1300 | 1974 | 1974.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R STEELE | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1301 | 7894 | 1973.5 | 305.7 | 76.4 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1302 | 3945 | 1972.5 | 132.7 | 66.3 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | False |
| 1303 | 3944 | 1972.0 | 100.3 | 50.1 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1304 | 1972 | 1972.0 | 63.2 | 63.2 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | False |
| 1305 | 3941 | 1970.5 | 76.7 | 38.4 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1306 | 3939 | 1969.5 | 114.8 | 57.4 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1307 | 9838 | 1967.6 | 224.7 | 44.9 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1308 | 1967 | 1967.0 | 58.5 | 58.5 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1309 | 1967 | 1967.0 | 38.6 | 38.6 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1310 | 1967 | 1967.0 | 50.8 | 50.8 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | False |
| 1311 | 3934 | 1967.0 | 90.6 | 45.3 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | False |
| 1312 | 3933 | 1966.5 | 94.5 | 47.2 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | False |
| 1313 | 1966 | 1966.0 | 57.6 | 57.6 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | False |
| 1314 | 1966 | 1966.0 | 48.5 | 48.5 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1315 | 3931 | 1965.5 | 126.1 | 63.0 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1316 | 3924 | 1962.0 | 113.9 | 57.0 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1317 | 1960 | 1960.0 | 15.9 | 15.9 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1318 | 3920 | 1960.0 | 122.5 | 61.2 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | False |
| 1319 | 5878 | 1959.3 | 193.2 | 64.4 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1320 | 1959 | 1959.0 | 58.7 | 58.7 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1321 | 1959 | 1959.0 | 41.2 | 41.2 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | False |
| 1322 | 1959 | 1959.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B WOOLF | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1323 | 1958 | 1958.0 | 70.7 | 70.7 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | False |
| 1324 | 1957 | 1957.0 | 55.6 | 55.6 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | False |
| 1325 | 11741 | 1956.8 | 335.5 | 55.9 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1326 | 1956 | 1956.0 | 55.4 | 55.4 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | False |
| 1327 | 1956 | 1956.0 | 44.8 | 44.8 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | False |
| 1328 | 1956 | 1956.0 | 66.3 | 66.3 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1329 | 1956 | 1956.0 | 77.2 | 77.2 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | False |
| 1330 | 3910 | 1955.0 | 120.5 | 60.2 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | False |
| 1331 | 3909 | 1954.5 | 135.6 | 67.8 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | False |
| 1332 | 5862 | 1954.0 | 147.9 | 49.3 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1333 | 3908 | 1954.0 | 73.6 | 36.8 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | False |
| 1334 | 1954 | 1954.0 | 50.4 | 50.4 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | False |
| 1335 | 3908 | 1954.0 | 96.3 | 48.1 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1336 | 1953 | 1953.0 | 57.4 | 57.4 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1337 | 3903 | 1951.5 | 79.8 | 39.9 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | False |
| 1338 | 1949 | 1949.0 | 63.4 | 63.4 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | False |
| 1339 | 1948 | 1948.0 | 78.4 | 78.4 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | False |
| 1340 | 3896 | 1948.0 | 65.6 | 32.8 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1341 | 1947 | 1947.0 | 41.1 | 41.1 | The etiology of chondromalacia patellae. | R E OUTERBRIDGE | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1342 | 1946 | 1946.0 | 45.7 | 45.7 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | False |
| 1343 | 11674 | 1945.7 | 335.4 | 55.9 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1344 | 3887 | 1943.5 | 109.3 | 54.6 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | False |
| 1345 | 1943 | 1943.0 | 42.6 | 42.6 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1346 | 3885 | 1942.5 | 101.5 | 50.8 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | False |
| 1347 | 3884 | 1942.0 | 85.4 | 42.7 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1348 | 5826 | 1942.0 | 119.4 | 39.8 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1349 | 1942 | 1942.0 | 54.1 | 54.1 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | False |
| 1350 | 1942 | 1942.0 | 42.4 | 42.4 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | False |
| 1351 | 3883 | 1941.5 | 114.3 | 57.1 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1352 | 3883 | 1941.5 | 105.1 | 52.5 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | False |
| 1353 | 5824 | 1941.3 | 168.6 | 56.2 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | False |
| 1354 | 1941 | 1941.0 | 70.4 | 70.4 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1355 | 1941 | 1941.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V BOYDEN | J Exp Med | 1951 | 14803635 | Yes |
| 1356 | 5821 | 1940.3 | 148.3 | 49.4 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1357 | 1940 | 1940.0 | 51.4 | 51.4 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | False |
| 1358 | 1939 | 1939.0 | 42.0 | 42.0 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | False |
| 1359 | 1938 | 1938.0 | 63.9 | 63.9 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | False |
| 1360 | 1938 | 1938.0 | 33.8 | 33.8 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | False |
| 1361 | 1938 | 1938.0 | 47.7 | 47.7 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | False |
| 1362 | 1937 | 1937.0 | 64.0 | 64.0 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1363 | 1937 | 1937.0 | 45.7 | 45.7 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | False |
| 1364 | 1936 | 1936.0 | 45.6 | 45.6 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1365 | 1935 | 1935.0 | 54.9 | 54.9 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | False |
| 1366 | 3866 | 1933.0 | 69.1 | 34.5 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | False |
| 1367 | 3865 | 1932.5 | 79.7 | 39.9 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1368 | 1932 | 1932.0 | 72.3 | 72.3 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | False |
| 1369 | 13520 | 1931.4 | 362.5 | 51.8 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1370 | 1931 | 1931.0 | 61.6 | 61.6 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1371 | 3860 | 1930.0 | 102.5 | 51.2 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | False |
| 1372 | 5785 | 1928.3 | 244.9 | 81.6 | Shedding light on the cell biology of extracellular vesicles. | Guillaume van Niel, Gisela D'Angelo, Graça Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | False |
| 1373 | 1928 | 1928.0 | 51.3 | 51.3 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | False |
| 1374 | 11567 | 1927.8 | 265.0 | 44.2 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1375 | 3855 | 1927.5 | 102.5 | 51.2 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | False |
| 1376 | 1927 | 1927.0 | 50.3 | 50.3 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | False |
| 1377 | 1926 | 1926.0 | 55.3 | 55.3 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | False |
| 1378 | 13480 | 1925.7 | 473.3 | 67.6 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1379 | 7702 | 1925.5 | 187.5 | 46.9 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | False |
| 1380 | 3851 | 1925.5 | 84.1 | 42.0 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | False |
| 1381 | 7701 | 1925.2 | 321.1 | 80.3 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1382 | 1925 | 1925.0 | 46.5 | 46.5 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | False |
| 1383 | 1924 | 1924.0 | 41.4 | 41.4 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | False |
| 1384 | 1923 | 1923.0 | 40.9 | 40.9 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | False |
| 1385 | 1922 | 1922.0 | 50.0 | 50.0 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | False |
| 1386 | 3844 | 1922.0 | 76.0 | 38.0 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1387 | 1921 | 1921.0 | 69.2 | 69.2 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1388 | 3841 | 1920.5 | 87.0 | 43.5 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1389 | 3841 | 1920.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J VOGEL, D M BONNER | J Biol Chem | 1956 | 13278318 | Yes |
| 1390 | 1919 | 1919.0 | 46.7 | 46.7 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | False |
| 1391 | 7671 | 1917.8 | 257.0 | 64.2 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | False |
| 1392 | 1916 | 1916.0 | 39.7 | 39.7 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1393 | 3830 | 1915.0 | 86.3 | 43.1 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | False |
| 1394 | 1915 | 1915.0 | 63.7 | 63.7 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | False |
| 1395 | 1913 | 1913.0 | 53.0 | 53.0 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | False |
| 1396 | 1912 | 1912.0 | 74.7 | 74.7 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1397 | 1912 | 1912.0 | 60.9 | 60.9 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | False |
| 1398 | 1912 | 1912.0 | 69.1 | 69.1 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | False |
| 1399 | 5733 | 1911.0 | 124.7 | 41.6 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1400 | 1909 | 1909.0 | 53.8 | 53.8 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1401 | 3818 | 1909.0 | 139.1 | 69.5 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1402 | 1908 | 1908.0 | 56.1 | 56.1 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | False |
| 1403 | 5723 | 1907.7 | 255.6 | 85.2 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1404 | 5716 | 1905.3 | 338.2 | 112.7 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1405 | 1905 | 1905.0 | 50.8 | 50.8 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | False |
| 1406 | 1904 | 1904.0 | 46.2 | 46.2 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1407 | 5711 | 1903.7 | 150.1 | 50.0 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1408 | 3805 | 1902.5 | 126.8 | 63.4 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1409 | 3805 | 1902.5 | 84.8 | 42.4 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1410 | 3805 | 1902.5 | 123.8 | 61.9 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1411 | 1902 | 1902.0 | 60.8 | 60.8 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1412 | 1902 | 1902.0 | 39.8 | 39.8 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | False |
| 1413 | 1900 | 1900.0 | 51.1 | 51.1 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1414 | 1900 | 1900.0 | 41.9 | 41.9 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1415 | 1900 | 1900.0 | 41.0 | 41.0 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | False |
| 1416 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H HIRS | J Biol Chem | 1956 | 13319283 | Yes |
| 1417 | 1897 | 1897.0 | 50.6 | 50.6 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | False |
| 1418 | 5686 | 1895.3 | 168.1 | 56.0 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1419 | 1894 | 1894.0 | 87.3 | 87.3 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1420 | 1893 | 1893.0 | 82.8 | 82.8 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | False |
| 1421 | 1892 | 1892.0 | 75.6 | 75.6 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | False |
| 1422 | 5673 | 1891.0 | 116.3 | 38.8 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1423 | 7563 | 1890.8 | 252.3 | 63.1 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1424 | 3779 | 1889.5 | 89.3 | 44.6 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1425 | 1889 | 1889.0 | 67.2 | 67.2 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | False |
| 1426 | 1888 | 1888.0 | 61.3 | 61.3 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1427 | 3776 | 1888.0 | 112.5 | 56.2 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1428 | 1887 | 1887.0 | 37.3 | 37.3 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | False |
| 1429 | 1887 | 1887.0 | 56.7 | 56.7 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | False |
| 1430 | 3773 | 1886.5 | 188.5 | 94.2 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1431 | 3773 | 1886.5 | 88.3 | 44.1 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | False |
| 1432 | 1886 | 1886.0 | 50.1 | 50.1 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1433 | 5655 | 1885.0 | 124.8 | 41.6 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1434 | 3764 | 1882.0 | 85.3 | 42.6 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | False |
| 1435 | 1881 | 1881.0 | 43.8 | 43.8 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | False |
| 1436 | 1881 | 1881.0 | 43.4 | 43.4 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
| 1437 | 3761 | 1880.5 | 76.9 | 38.5 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | False |
| 1438 | 3760 | 1880.0 | 101.0 | 50.5 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | False |
| 1439 | 1876 | 1876.0 | 85.7 | 85.7 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | False |
| 1440 | 1876 | 1876.0 | 65.5 | 65.5 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1441 | 3750 | 1875.0 | 138.2 | 69.1 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1442 | 1874 | 1874.0 | 36.8 | 36.8 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | False |
| 1443 | 1873 | 1873.0 | 19.6 | 19.6 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1444 | 3746 | 1873.0 | 77.2 | 38.6 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1445 | 5613 | 1871.0 | 115.2 | 38.4 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1446 | 1871 | 1871.0 | 72.3 | 72.3 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | False |
| 1447 | 5612 | 1870.7 | 139.2 | 46.4 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1448 | 1870 | 1870.0 | 37.3 | 37.3 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1449 | 1870 | 1870.0 | 54.7 | 54.7 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | False |
| 1450 | 3740 | 1870.0 | 106.9 | 53.5 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1451 | 7477 | 1869.2 | 179.0 | 44.8 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1452 | 1869 | 1869.0 | 37.2 | 37.2 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | False |
| 1453 | 1869 | 1869.0 | 50.8 | 50.8 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1454 | 3735 | 1867.5 | 168.1 | 84.0 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 1455 | 1867 | 1867.0 | 35.1 | 35.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | False |
| 1456 | 1867 | 1867.0 | 49.5 | 49.5 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1457 | 1866 | 1866.0 | 54.0 | 54.0 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | False |
| 1458 | 1865 | 1865.0 | 48.5 | 48.5 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | False |
| 1459 | 1865 | 1865.0 | 36.2 | 36.2 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | False |
| 1460 | 1864 | 1864.0 | 75.4 | 75.4 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | False |
| 1461 | 1864 | 1864.0 | 53.8 | 53.8 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | False |
| 1462 | 7450 | 1862.5 | 209.1 | 52.3 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | False |
| 1463 | 1862 | 1862.0 | 58.1 | 58.1 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | False |
| 1464 | 1861 | 1861.0 | 70.4 | 70.4 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | False |
| 1465 | 1861 | 1861.0 | 44.5 | 44.5 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | False |
| 1466 | 9303 | 1860.6 | 331.1 | 66.2 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1467 | 3720 | 1860.0 | 120.2 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | False |
| 1468 | 1859 | 1859.0 | 49.8 | 49.8 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1469 | 1858 | 1858.0 | 52.1 | 52.1 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1470 | 3715 | 1857.5 | 77.8 | 38.9 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1471 | 3713 | 1856.5 | 103.7 | 51.9 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1472 | 3713 | 1856.5 | 77.3 | 38.6 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1473 | 14850 | 1856.2 | 415.0 | 51.9 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1474 | 1854 | 1854.0 | 42.7 | 42.7 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1475 | 1854 | 1854.0 | 35.8 | 35.8 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | False |
| 1476 | 9265 | 1853.0 | 210.3 | 42.1 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1477 | 3705 | 1852.5 | 75.1 | 37.5 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | False |
| 1478 | 3705 | 1852.5 | 122.7 | 61.4 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | False |
| 1479 | 7409 | 1852.2 | 336.9 | 84.2 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 1480 | 1852 | 1852.0 | 66.2 | 66.2 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1481 | 1852 | 1852.0 | 33.6 | 33.6 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1482 | 1852 | 1852.0 | 33.4 | 33.4 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | False |
| 1483 | 1852 | 1852.0 | 45.9 | 45.9 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | False |
| 1484 | 1850 | 1850.0 | 57.6 | 57.6 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1485 | 1850 | 1850.0 | 17.8 | 17.8 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A ROBINSON | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1486 | 3700 | 1850.0 | 112.6 | 56.3 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | False |
| 1487 | 5548 | 1849.3 | 102.9 | 34.3 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | False |
| 1488 | 1848 | 1848.0 | 45.6 | 45.6 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | False |
| 1489 | 1848 | 1848.0 | 47.4 | 47.4 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | False |
| 1490 | 3695 | 1847.5 | 97.9 | 49.0 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | False |
| 1491 | 7386 | 1846.5 | 195.1 | 48.8 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 1492 | 7384 | 1846.0 | 340.2 | 85.0 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1493 | 1846 | 1846.0 | 41.1 | 41.1 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | False |
| 1494 | 3691 | 1845.5 | 52.9 | 26.4 | Immunoassay of insulin with insulin-antibody precipitate. | C N HALES, P J RANDLE | Biochem J | 1963 | 13952078 | Yes |
| 1495 | 1845 | 1845.0 | 33.5 | 33.5 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | False |
| 1496 | 9219 | 1843.8 | 236.1 | 47.2 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1497 | 3686 | 1843.0 | 277.6 | 138.8 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | False |
| 1498 | 3685 | 1842.5 | 187.7 | 93.8 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1499 | 3683 | 1841.5 | 84.0 | 42.0 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | False |
| 1500 | 1839 | 1839.0 | 38.7 | 38.7 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | False |
| 1501 | 1837 | 1837.0 | 50.0 | 50.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | False |
| 1502 | 1836 | 1836.0 | 42.0 | 42.0 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | False |
| 1503 | 1835 | 1835.0 | 67.3 | 67.3 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | False |
| 1504 | 1835 | 1835.0 | 37.4 | 37.4 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | False |
| 1505 | 1835 | 1835.0 | 56.5 | 56.5 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | False |
| 1506 | 3670 | 1835.0 | 99.6 | 49.8 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | False |
| 1507 | 1834 | 1834.0 | 42.0 | 42.0 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1508 | 1834 | 1834.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D SIMPSON | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1509 | 1834 | 1834.0 | 36.4 | 36.4 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
| 1510 | 5501 | 1833.7 | 283.5 | 94.5 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 1511 | 1833 | 1833.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C SKOU | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1512 | 1832 | 1832.0 | 43.7 | 43.7 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1513 | 5495 | 1831.7 | 121.3 | 40.4 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1514 | 1831 | 1831.0 | 59.4 | 59.4 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | False |
| 1515 | 5492 | 1830.7 | 141.6 | 47.2 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | False |
| 1516 | 3661 | 1830.5 | 113.4 | 56.7 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1517 | 3661 | 1830.5 | 102.3 | 51.1 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 1518 | 1830 | 1830.0 | 43.1 | 43.1 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | False |
| 1519 | 3658 | 1829.0 | 92.8 | 46.4 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1520 | 1828 | 1828.0 | 48.7 | 48.7 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1521 | 1828 | 1828.0 | 45.3 | 45.3 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | False |
| 1522 | 3656 | 1828.0 | 130.2 | 65.1 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 1523 | 5483 | 1827.7 | 120.7 | 40.2 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | False |
| 1524 | 1827 | 1827.0 | 60.0 | 60.0 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | False |
| 1525 | 1827 | 1827.0 | 42.0 | 42.0 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | False |
| 1526 | 1826 | 1826.0 | 67.9 | 67.9 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1527 | 1826 | 1826.0 | 42.8 | 42.8 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | False |
| 1528 | 1826 | 1826.0 | 41.6 | 41.6 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | False |
| 1529 | 7298 | 1824.5 | 139.1 | 34.8 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | False |
| 1530 | 3647 | 1823.5 | 140.9 | 70.5 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1531 | 1823 | 1823.0 | 53.6 | 53.6 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | False |
| 1532 | 3644 | 1822.0 | 95.0 | 47.5 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | False |
| 1533 | 1821 | 1821.0 | 88.9 | 88.9 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S COHEN | J Biol Chem | 1962 | 13880319 | Yes |
| 1534 | 1820 | 1820.0 | 46.8 | 46.8 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | False |
| 1535 | 3634 | 1817.0 | 129.6 | 64.8 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1536 | 1817 | 1817.0 | 54.1 | 54.1 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1537 | 1817 | 1817.0 | 62.4 | 62.4 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | False |
| 1538 | 1816 | 1816.0 | 43.7 | 43.7 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | False |
| 1539 | 1816 | 1816.0 | 49.8 | 49.8 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1540 | 1816 | 1816.0 | 73.6 | 73.6 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | False |
| 1541 | 1815 | 1815.0 | 36.4 | 36.4 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | False |
| 1542 | 1815 | 1815.0 | 52.2 | 52.2 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1543 | 3628 | 1814.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T CAMPBELL, D W FISKE | Psychol Bull | 1959 | 13634291 | Yes |
| 1544 | 1814 | 1814.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1545 | 9069 | 1813.8 | 218.5 | 43.7 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1546 | 1813 | 1813.0 | 34.1 | 34.1 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | False |
| 1547 | 1813 | 1813.0 | 79.8 | 79.8 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1548 | 1812 | 1812.0 | 40.7 | 40.7 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | False |
| 1549 | 3624 | 1812.0 | 94.1 | 47.0 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | False |
| 1550 | 3622 | 1811.0 | 116.0 | 58.0 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | False |
| 1551 | 5433 | 1811.0 | 139.5 | 46.5 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1552 | 1811 | 1811.0 | 59.1 | 59.1 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1553 | 1811 | 1811.0 | 41.2 | 41.2 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | False |
| 1554 | 7241 | 1810.2 | 206.9 | 51.7 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1555 | 1810 | 1810.0 | 62.9 | 62.9 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | False |
| 1556 | 1808 | 1808.0 | 54.6 | 54.6 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | False |
| 1557 | 3614 | 1807.0 | 132.0 | 66.0 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | False |
| 1558 | 1807 | 1807.0 | 53.7 | 53.7 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1559 | 1806 | 1806.0 | 40.9 | 40.9 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1560 | 1804 | 1804.0 | 37.5 | 37.5 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | False |
| 1561 | 3606 | 1803.0 | 74.9 | 37.5 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | False |
| 1562 | 1802 | 1802.0 | 42.9 | 42.9 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1563 | 18017 | 1801.7 | 562.4 | 56.2 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1564 | 3603 | 1801.5 | 133.9 | 67.0 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1565 | 9006 | 1801.2 | 428.2 | 85.6 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 1566 | 1800 | 1800.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J WHITNEY | J Physiol | 1953 | 13085295 | Yes |
| 1567 | 1800 | 1800.0 | 38.0 | 38.0 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1568 | 5399 | 1799.7 | 174.4 | 58.1 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1569 | 3599 | 1799.5 | 86.0 | 43.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | False |
| 1570 | 10787 | 1797.8 | 289.3 | 48.2 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1571 | 3595 | 1797.5 | 83.7 | 41.9 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 1572 | 3593 | 1796.5 | 89.7 | 44.9 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1573 | 8981 | 1796.2 | 95.7 | 19.1 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE | JAMA | 1963 | 14044222 | Yes |
| 1574 | 1796 | 1796.0 | 97.7 | 97.7 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1575 | 1796 | 1796.0 | 43.0 | 43.0 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | False |
| 1576 | 3590 | 1795.0 | 104.7 | 52.4 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1577 | 3589 | 1794.5 | 106.1 | 53.0 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | False |
| 1578 | 1794 | 1794.0 | 43.5 | 43.5 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1579 | 3587 | 1793.5 | 83.3 | 41.6 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1580 | 1792 | 1792.0 | 37.5 | 37.5 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | False |
| 1581 | 3583 | 1791.5 | 80.1 | 40.0 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | False |
| 1582 | 1791 | 1791.0 | 61.5 | 61.5 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | False |
| 1583 | 1790 | 1790.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S HESTRIN | J Biol Chem | 1949 | 18133390 | Yes |
| 1584 | 1790 | 1790.0 | 19.4 | 19.4 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1585 | 3579 | 1789.5 | 88.5 | 44.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | False |
| 1586 | 3578 | 1789.0 | 163.4 | 81.7 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | False |
| 1587 | 1788 | 1788.0 | 57.1 | 57.1 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | False |
| 1588 | 1788 | 1788.0 | 55.9 | 55.9 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1589 | 1787 | 1787.0 | 46.9 | 46.9 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1590 | 1785 | 1785.0 | 41.0 | 41.0 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | False |
| 1591 | 1785 | 1785.0 | 54.4 | 54.4 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1592 | 3567 | 1783.5 | 102.0 | 51.0 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | False |
| 1593 | 1783 | 1783.0 | 58.9 | 58.9 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | False |
| 1594 | 1783 | 1783.0 | 35.5 | 35.5 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | False |
| 1595 | 3562 | 1781.0 | 150.5 | 75.2 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1596 | 1781 | 1781.0 | 87.2 | 87.2 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | False |
| 1597 | 3562 | 1781.0 | 139.3 | 69.7 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | False |
| 1598 | 1781 | 1781.0 | 173.8 | 173.8 | Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. | Brent R Stockwell | Cell | 2022 | 35803244 | False |
| 1599 | 7121 | 1780.2 | 276.0 | 69.0 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1600 | 1780 | 1780.0 | 37.7 | 37.7 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | False |
| 1601 | 1780 | 1780.0 | 38.6 | 38.6 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | False |
| 1602 | 3558 | 1779.0 | 88.2 | 44.1 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1603 | 1779 | 1779.0 | 47.1 | 47.1 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | False |
| 1604 | 1779 | 1779.0 | 35.9 | 35.9 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1605 | 5336 | 1778.7 | 150.4 | 50.1 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallières, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
| 1606 | 3556 | 1778.0 | 86.3 | 43.1 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | False |
| 1607 | 3556 | 1778.0 | 103.3 | 51.6 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | False |
| 1608 | 3552 | 1776.0 | 152.0 | 76.0 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1609 | 1774 | 1774.0 | 38.7 | 38.7 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1610 | 3547 | 1773.5 | 225.9 | 113.0 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1611 | 1773 | 1773.0 | 49.4 | 49.4 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1612 | 1772 | 1772.0 | 39.1 | 39.1 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1613 | 1772 | 1772.0 | 41.1 | 41.1 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1614 | 3542 | 1771.0 | 73.2 | 36.6 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1615 | 1771 | 1771.0 | 62.9 | 62.9 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | False |
| 1616 | 1769 | 1769.0 | 46.5 | 46.5 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | False |
| 1617 | 7074 | 1768.5 | 305.0 | 76.2 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1618 | 1768 | 1768.0 | 57.9 | 57.9 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1619 | 1767 | 1767.0 | 58.5 | 58.5 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | False |
| 1620 | 3533 | 1766.5 | 43.9 | 21.9 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1621 | 1766 | 1766.0 | 45.3 | 45.3 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1622 | 3532 | 1766.0 | 125.9 | 63.0 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | False |
| 1623 | 1763 | 1763.0 | 66.0 | 66.0 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1624 | 1763 | 1763.0 | 47.2 | 47.2 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1625 | 1762 | 1762.0 | 52.6 | 52.6 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1626 | 1762 | 1762.0 | 53.8 | 53.8 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | False |
| 1627 | 1762 | 1762.0 | 64.9 | 64.9 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | False |
| 1628 | 1761 | 1761.0 | 40.1 | 40.1 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | False |
| 1629 | 3521 | 1760.5 | 72.7 | 36.4 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | False |
| 1630 | 1760 | 1760.0 | 38.8 | 38.8 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
| 1631 | 1760 | 1760.0 | 60.4 | 60.4 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1632 | 1760 | 1760.0 | 21.1 | 21.1 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1633 | 1760 | 1760.0 | 33.2 | 33.2 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1634 | 3519 | 1759.5 | 88.2 | 44.1 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | False |
| 1635 | 5278 | 1759.3 | 119.4 | 39.8 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1636 | 1759 | 1759.0 | 42.3 | 42.3 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1637 | 3518 | 1759.0 | 166.5 | 83.2 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | False |
| 1638 | 5276 | 1758.7 | 114.0 | 38.0 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1639 | 3517 | 1758.5 | 93.0 | 46.5 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1640 | 1757 | 1757.0 | 37.1 | 37.1 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1641 | 5270 | 1756.7 | 163.2 | 54.4 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | False |
| 1642 | 1756 | 1756.0 | 33.7 | 33.7 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | False |
| 1643 | 7021 | 1755.2 | 212.5 | 53.1 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1644 | 3510 | 1755.0 | 67.9 | 34.0 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1645 | 1755 | 1755.0 | 38.4 | 38.4 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | False |
| 1646 | 1755 | 1755.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A TAYLOR | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1647 | 5263 | 1754.3 | 122.4 | 40.8 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1648 | 1754 | 1754.0 | 76.9 | 76.9 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1649 | 1753 | 1753.0 | 64.3 | 64.3 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1650 | 3506 | 1753.0 | 149.3 | 74.7 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1651 | 1753 | 1753.0 | 40.0 | 40.0 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1652 | 3505 | 1752.5 | 109.6 | 54.8 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1653 | 1752 | 1752.0 | 44.3 | 44.3 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | False |
| 1654 | 1752 | 1752.0 | 38.1 | 38.1 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | False |
| 1655 | 1751 | 1751.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1656 | 3500 | 1750.0 | 80.4 | 40.2 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | False |
| 1657 | 3499 | 1749.5 | 225.0 | 112.5 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1658 | 3498 | 1749.0 | 80.0 | 40.0 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | False |
| 1659 | 3498 | 1749.0 | 85.4 | 42.7 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1660 | 1749 | 1749.0 | 63.4 | 63.4 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1661 | 1748 | 1748.0 | 74.1 | 74.1 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | False |
| 1662 | 1748 | 1748.0 | 60.5 | 60.5 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1663 | 6991 | 1747.8 | 136.0 | 34.0 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1664 | 1747 | 1747.0 | 59.3 | 59.3 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | False |
| 1665 | 1746 | 1746.0 | 41.5 | 41.5 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1666 | 1746 | 1746.0 | 41.7 | 41.7 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1667 | 1745 | 1745.0 | 54.0 | 54.0 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | False |
| 1668 | 3490 | 1745.0 | 89.2 | 44.6 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1669 | 10465 | 1744.2 | 210.9 | 35.1 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1670 | 1744 | 1744.0 | 48.5 | 48.5 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | False |
| 1671 | 1742 | 1742.0 | 59.2 | 59.2 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | False |
| 1672 | 19161 | 1741.9 | 480.9 | 43.7 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1673 | 1741 | 1741.0 | 62.6 | 62.6 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1674 | 3482 | 1741.0 | 93.7 | 46.9 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1675 | 1741 | 1741.0 | 38.7 | 38.7 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | False |
| 1676 | 1741 | 1741.0 | 47.8 | 47.8 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | False |
| 1677 | 1739 | 1739.0 | 31.6 | 31.6 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1678 | 5216 | 1738.7 | 111.3 | 37.1 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | False |
| 1679 | 1738 | 1738.0 | 39.0 | 39.0 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | False |
| 1680 | 3475 | 1737.5 | 86.3 | 43.1 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1681 | 1737 | 1737.0 | 38.3 | 38.3 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | False |
| 1682 | 3474 | 1737.0 | 79.8 | 39.9 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | False |
| 1683 | 3473 | 1736.5 | 99.6 | 49.8 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | False |
| 1684 | 1735 | 1735.0 | 39.0 | 39.0 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | False |
| 1685 | 1733 | 1733.0 | 59.8 | 59.8 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1686 | 1733 | 1733.0 | 56.1 | 56.1 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1687 | 17327 | 1732.7 | 547.4 | 54.7 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1688 | 3465 | 1732.5 | 71.3 | 35.6 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | False |
| 1689 | 1732 | 1732.0 | 62.3 | 62.3 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | False |
| 1690 | 1732 | 1732.0 | 17.3 | 17.3 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1691 | 1732 | 1732.0 | 69.3 | 69.3 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1692 | 10389 | 1731.5 | 286.6 | 47.8 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1693 | 6922 | 1730.5 | 218.0 | 54.5 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1694 | 1730 | 1730.0 | 45.5 | 45.5 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | False |
| 1695 | 1730 | 1730.0 | 46.3 | 46.3 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | False |
| 1696 | 5189 | 1729.7 | 111.5 | 37.2 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1697 | 3459 | 1729.5 | 68.7 | 34.4 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | False |
| 1698 | 3458 | 1729.0 | 82.0 | 41.0 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1699 | 1728 | 1728.0 | 63.0 | 63.0 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | False |
| 1700 | 1727 | 1727.0 | 32.8 | 32.8 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1701 | 1727 | 1727.0 | 52.5 | 52.5 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1702 | 3453 | 1726.5 | 89.6 | 44.8 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | False |
| 1703 | 1725 | 1725.0 | 56.0 | 56.0 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | False |
| 1704 | 3450 | 1725.0 | 71.3 | 35.6 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
| 1705 | 1725 | 1725.0 | 73.6 | 73.6 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1706 | 5169 | 1723.0 | 274.6 | 91.5 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1707 | 1723 | 1723.0 | 68.3 | 68.3 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1708 | 1723 | 1723.0 | 31.3 | 31.3 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | False |
| 1709 | 1723 | 1723.0 | 39.9 | 39.9 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | False |
| 1710 | 1723 | 1723.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H SELYE | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1711 | 3445 | 1722.5 | 87.0 | 43.5 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1712 | 6889 | 1722.2 | 240.7 | 60.2 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 1713 | 1722 | 1722.0 | 31.3 | 31.3 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | False |
| 1714 | 1722 | 1722.0 | 35.9 | 35.9 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | False |
| 1715 | 5164 | 1721.3 | 230.7 | 76.9 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1716 | 3442 | 1721.0 | 96.4 | 48.2 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1717 | 5162 | 1720.7 | 202.1 | 67.4 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1718 | 1720 | 1720.0 | 44.3 | 44.3 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | False |
| 1719 | 6878 | 1719.5 | 260.2 | 65.0 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 1720 | 3437 | 1718.5 | 110.8 | 55.4 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | False |
| 1721 | 1718 | 1718.0 | 73.9 | 73.9 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1722 | 3436 | 1718.0 | 91.9 | 46.0 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | False |
| 1723 | 3435 | 1717.5 | 96.7 | 48.4 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1724 | 3434 | 1717.0 | 70.1 | 35.0 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | False |
| 1725 | 1716 | 1716.0 | 41.9 | 41.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1726 | 1716 | 1716.0 | 0.0 | 0.0 | A new readability yardstick. | R FLESCH | J Appl Psychol | 1948 | 18867058 | Yes |
| 1727 | 12010 | 1715.7 | 3955.9 | 565.1 | Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Mathieu Laversanne, Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Isabelle Soerjomataram, Ahmedin Jemal | CA Cancer J Clin | 2024 | 38572751 | Yes |
| 1728 | 1715 | 1715.0 | 65.5 | 65.5 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | False |
| 1729 | 1715 | 1715.0 | 44.2 | 44.2 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | False |
| 1730 | 1715 | 1715.0 | 35.8 | 35.8 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | False |
| 1731 | 1715 | 1715.0 | 33.5 | 33.5 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | False |
| 1732 | 6858 | 1714.5 | 143.8 | 36.0 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1733 | 3424 | 1712.0 | 126.7 | 63.4 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1734 | 1711 | 1711.0 | 44.8 | 44.8 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1735 | 3422 | 1711.0 | 74.5 | 37.2 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | False |
| 1736 | 1711 | 1711.0 | 30.7 | 30.7 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | False |
| 1737 | 3420 | 1710.0 | 131.0 | 65.5 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1738 | 1709 | 1709.0 | 51.8 | 51.8 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | False |
| 1739 | 3418 | 1709.0 | 82.3 | 41.1 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1740 | 1709 | 1709.0 | 92.3 | 92.3 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | False |
| 1741 | 1708 | 1708.0 | 71.7 | 71.7 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | False |
| 1742 | 3415 | 1707.5 | 49.7 | 24.9 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J KARNOVSKY, L ROOTS | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1743 | 1707 | 1707.0 | 65.3 | 65.3 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | False |
| 1744 | 1706 | 1706.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J RANKIN | Scott Med J | 1957 | 13432835 | Yes |
| 1745 | 8530 | 1706.0 | 349.8 | 70.0 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 1746 | 1705 | 1705.0 | 48.0 | 48.0 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | False |
| 1747 | 1705 | 1705.0 | 37.4 | 37.4 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 1748 | 3403 | 1701.5 | 93.4 | 46.7 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1749 | 1700 | 1700.0 | 42.7 | 42.7 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | False |
| 1750 | 15298 | 1699.8 | 465.3 | 51.7 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | False |
| 1751 | 3398 | 1699.0 | 80.9 | 40.5 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1752 | 1698 | 1698.0 | 40.7 | 40.7 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | False |
| 1753 | 1697 | 1697.0 | 46.7 | 46.7 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 1754 | 5088 | 1696.0 | 119.1 | 39.7 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | False |
| 1755 | 3391 | 1695.5 | 65.2 | 32.6 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | False |
| 1756 | 1695 | 1695.0 | 32.8 | 32.8 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | False |
| 1757 | 1695 | 1695.0 | 45.5 | 45.5 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | False |
| 1758 | 3389 | 1694.5 | 112.2 | 56.1 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | False |
| 1759 | 1694 | 1694.0 | 57.1 | 57.1 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | False |
| 1760 | 1694 | 1694.0 | 38.4 | 38.4 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | False |
| 1761 | 3388 | 1694.0 | 66.6 | 33.3 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | False |
| 1762 | 3388 | 1694.0 | 77.8 | 38.9 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | False |
| 1763 | 3386 | 1693.0 | 85.2 | 42.6 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | False |
| 1764 | 3386 | 1693.0 | 127.6 | 63.8 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 1765 | 1692 | 1692.0 | 83.2 | 83.2 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
| 1766 | 3384 | 1692.0 | 78.8 | 39.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | False |
| 1767 | 1692 | 1692.0 | 44.9 | 44.9 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | False |
| 1768 | 1692 | 1692.0 | 39.9 | 39.9 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1769 | 3384 | 1692.0 | 93.1 | 46.5 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | False |
| 1770 | 1692 | 1692.0 | 55.2 | 55.2 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | False |
| 1771 | 1691 | 1691.0 | 29.3 | 29.3 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H MOLLENHAUER | Stain Technol | 1964 | 14127791 | Yes |
| 1772 | 1690 | 1690.0 | 40.1 | 40.1 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | False |
| 1773 | 1690 | 1690.0 | 37.6 | 37.6 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | False |
| 1774 | 1689 | 1689.0 | 35.2 | 35.2 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | False |
| 1775 | 1689 | 1689.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P MORAN | Biometrika | 1950 | 15420245 | Yes |
| 1776 | 3378 | 1689.0 | 75.4 | 37.7 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1777 | 1688 | 1688.0 | 73.0 | 73.0 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 1778 | 3376 | 1688.0 | 72.1 | 36.0 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | False |
| 1779 | 5062 | 1687.3 | 96.8 | 32.3 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1780 | 1687 | 1687.0 | 37.8 | 37.8 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | False |
| 1781 | 1687 | 1687.0 | 54.9 | 54.9 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | False |
| 1782 | 3372 | 1686.0 | 110.2 | 55.1 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | False |
| 1783 | 1686 | 1686.0 | 31.1 | 31.1 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | False |
| 1784 | 1686 | 1686.0 | 51.0 | 51.0 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1785 | 1685 | 1685.0 | 58.5 | 58.5 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | False |
| 1786 | 1685 | 1685.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G GRAY | J Anat | 1959 | 13829103 | Yes |
| 1787 | 5055 | 1685.0 | 129.3 | 43.1 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1788 | 1684 | 1684.0 | 52.8 | 52.8 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | False |
| 1789 | 3368 | 1684.0 | 69.8 | 34.9 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1790 | 1684 | 1684.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A LASSEN | Physiol Rev | 1959 | 13645234 | Yes |
| 1791 | 1684 | 1684.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1792 | 3367 | 1683.5 | 103.0 | 51.5 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | False |
| 1793 | 3366 | 1683.0 | 194.9 | 97.5 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1794 | 1683 | 1683.0 | 40.9 | 40.9 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1795 | 1683 | 1683.0 | 43.0 | 43.0 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | False |
| 1796 | 10096 | 1682.7 | 231.1 | 38.5 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1797 | 3365 | 1682.5 | 112.1 | 56.0 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 1798 | 1682 | 1682.0 | 30.0 | 30.0 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | False |
| 1799 | 3364 | 1682.0 | 81.7 | 40.9 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 1800 | 1682 | 1682.0 | 69.7 | 69.7 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 1801 | 1681 | 1681.0 | 69.3 | 69.3 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | False |
| 1802 | 5042 | 1680.7 | 305.5 | 101.8 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 1803 | 3361 | 1680.5 | 70.7 | 35.4 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 1804 | 1680 | 1680.0 | 73.6 | 73.6 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1805 | 1680 | 1680.0 | 14.0 | 14.0 | Chromatographic Separation Of Human Brain Gangliosides. | L SVENNERHOLM | J Neurochem | 1963 | 14066623 | Yes |
| 1806 | 1679 | 1679.0 | 77.8 | 77.8 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | False |
| 1807 | 1678 | 1678.0 | 38.1 | 38.1 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | False |
| 1808 | 3356 | 1678.0 | 91.3 | 45.6 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | False |
| 1809 | 1677 | 1677.0 | 22.5 | 22.5 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1810 | 1677 | 1677.0 | 42.8 | 42.8 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | False |
| 1811 | 1677 | 1677.0 | 54.0 | 54.0 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1812 | 1676 | 1676.0 | 43.3 | 43.3 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1813 | 1676 | 1676.0 | 58.4 | 58.4 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | False |
| 1814 | 1676 | 1676.0 | 45.0 | 45.0 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1815 | 1675 | 1675.0 | 32.1 | 32.1 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | False |
| 1816 | 1674 | 1674.0 | 83.2 | 83.2 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | False |
| 1817 | 1673 | 1673.0 | 33.9 | 33.9 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | False |
| 1818 | 1672 | 1672.0 | 31.8 | 31.8 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | False |
| 1819 | 1672 | 1672.0 | 44.9 | 44.9 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | False |
| 1820 | 1671 | 1671.0 | 49.5 | 49.5 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | False |
| 1821 | 3341 | 1670.5 | 98.1 | 49.0 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1822 | 1670 | 1670.0 | 37.1 | 37.1 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | False |
| 1823 | 1670 | 1670.0 | 46.9 | 46.9 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | False |
| 1824 | 8347 | 1669.4 | 382.2 | 76.4 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 1825 | 10016 | 1669.3 | 345.1 | 57.5 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1826 | 1668 | 1668.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F BOAS | J Biol Chem | 1953 | 13117829 | Yes |
| 1827 | 1667 | 1667.0 | 48.6 | 48.6 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1828 | 1667 | 1667.0 | 62.0 | 62.0 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1829 | 5000 | 1666.7 | 109.2 | 36.4 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M G Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1830 | 3331 | 1665.5 | 54.3 | 27.1 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T OMURA, R SATO | J Biol Chem | 1964 | 14209972 | Yes |
| 1831 | 3330 | 1665.0 | 64.2 | 32.1 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | False |
| 1832 | 1664 | 1664.0 | 34.9 | 34.9 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | False |
| 1833 | 1664 | 1664.0 | 38.1 | 38.1 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | False |
| 1834 | 3327 | 1663.5 | 70.1 | 35.0 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | False |
| 1835 | 1663 | 1663.0 | 49.2 | 49.2 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | False |
| 1836 | 1663 | 1663.0 | 32.2 | 32.2 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1837 | 1663 | 1663.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S KETY | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1838 | 3326 | 1663.0 | 70.9 | 35.5 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | False |
| 1839 | 1662 | 1662.0 | 52.8 | 52.8 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | False |
| 1840 | 1661 | 1661.0 | 49.1 | 49.1 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1841 | 3322 | 1661.0 | 60.6 | 30.3 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1842 | 1661 | 1661.0 | 58.7 | 58.7 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1843 | 1661 | 1661.0 | 41.6 | 41.6 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | False |
| 1844 | 1660 | 1660.0 | 40.2 | 40.2 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | False |
| 1845 | 6636 | 1659.0 | 152.1 | 38.0 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1846 | 1659 | 1659.0 | 46.9 | 46.9 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1847 | 1659 | 1659.0 | 39.2 | 39.2 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | False |
| 1848 | 1658 | 1658.0 | 35.0 | 35.0 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | False |
| 1849 | 1657 | 1657.0 | 71.4 | 71.4 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | False |
| 1850 | 3313 | 1656.5 | 84.0 | 42.0 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1851 | 3311 | 1655.5 | 82.3 | 41.1 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 1852 | 3308 | 1654.0 | 71.2 | 35.6 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1853 | 3307 | 1653.5 | 72.0 | 36.0 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | False |
| 1854 | 1652 | 1652.0 | 41.0 | 41.0 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | False |
| 1855 | 4953 | 1651.0 | 135.7 | 45.2 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1856 | 1651 | 1651.0 | 56.6 | 56.6 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | False |
| 1857 | 1651 | 1651.0 | 31.3 | 31.3 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1858 | 3300 | 1650.0 | 85.6 | 42.8 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1859 | 1650 | 1650.0 | 36.5 | 36.5 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | False |
| 1860 | 1650 | 1650.0 | 43.3 | 43.3 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 1861 | 1649 | 1649.0 | 53.4 | 53.4 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1862 | 1649 | 1649.0 | 37.2 | 37.2 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | False |
| 1863 | 8245 | 1649.0 | 294.8 | 59.0 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | False |
| 1864 | 1649 | 1649.0 | 63.0 | 63.0 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | False |
| 1865 | 1648 | 1648.0 | 30.5 | 30.5 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | False |
| 1866 | 1647 | 1647.0 | 63.1 | 63.1 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1867 | 3293 | 1646.5 | 97.8 | 48.9 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | False |
| 1868 | 9877 | 1646.2 | 224.8 | 37.5 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 1869 | 1646 | 1646.0 | 33.3 | 33.3 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | False |
| 1870 | 1646 | 1646.0 | 23.0 | 23.0 | Structural considerations in the interaction of DNA and acridines. | L S LERMAN | J Mol Biol | 1961 | 13761054 | Yes |
| 1871 | 1646 | 1646.0 | 37.4 | 37.4 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1872 | 6583 | 1645.8 | 155.8 | 39.0 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1873 | 1645 | 1645.0 | 48.3 | 48.3 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | False |
| 1874 | 1645 | 1645.0 | 45.0 | 45.0 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | False |
| 1875 | 1645 | 1645.0 | 36.2 | 36.2 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | Yes |
| 1876 | 1645 | 1645.0 | 49.6 | 49.6 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | False |
| 1877 | 3289 | 1644.5 | 69.4 | 34.7 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | False |
| 1878 | 1644 | 1644.0 | 47.5 | 47.5 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | False |
| 1879 | 4931 | 1643.7 | 118.2 | 39.4 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1880 | 3286 | 1643.0 | 80.4 | 40.2 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | False |
| 1881 | 1642 | 1642.0 | 36.7 | 36.7 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | False |
| 1882 | 1642 | 1642.0 | 39.0 | 39.0 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | False |
| 1883 | 1641 | 1641.0 | 34.8 | 34.8 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | False |
| 1884 | 1640 | 1640.0 | 45.2 | 45.2 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 1885 | 1640 | 1640.0 | 28.7 | 28.7 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 1886 | 3278 | 1639.0 | 96.6 | 48.3 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 1887 | 1639 | 1639.0 | 33.4 | 33.4 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | False |
| 1888 | 3277 | 1638.5 | 93.2 | 46.6 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | False |
| 1889 | 1638 | 1638.0 | 46.8 | 46.8 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | False |
| 1890 | 1637 | 1637.0 | 27.5 | 27.5 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | False |
| 1891 | 3273 | 1636.5 | 66.3 | 33.1 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | False |
| 1892 | 1636 | 1636.0 | 39.2 | 39.2 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | False |
| 1893 | 3271 | 1635.5 | 65.7 | 32.9 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1894 | 4905 | 1635.0 | 123.7 | 41.2 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1895 | 1634 | 1634.0 | 49.8 | 49.8 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | False |
| 1896 | 1634 | 1634.0 | 71.0 | 71.0 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1897 | 1634 | 1634.0 | 41.1 | 41.1 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | False |
| 1898 | 3268 | 1634.0 | 58.9 | 29.4 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | False |
| 1899 | 1634 | 1634.0 | 101.7 | 101.7 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D MATTINGLY | J Clin Pathol | 1962 | 14471419 | Yes |
| 1900 | 1634 | 1634.0 | 39.0 | 39.0 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1901 | 3268 | 1634.0 | 80.6 | 40.3 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | False |
| 1902 | 3267 | 1633.5 | 193.3 | 96.7 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | False |
| 1903 | 1633 | 1633.0 | 31.2 | 31.2 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | False |
| 1904 | 4898 | 1632.7 | 103.4 | 34.5 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | False |
| 1905 | 1632 | 1632.0 | 71.8 | 71.8 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | False |
| 1906 | 1632 | 1632.0 | 56.3 | 56.3 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | False |
| 1907 | 1631 | 1631.0 | 50.9 | 50.9 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | False |
| 1908 | 3261 | 1630.5 | 74.2 | 37.1 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | False |
| 1909 | 3260 | 1630.0 | 182.5 | 91.2 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J MARMUR, P DOTY | J Mol Biol | 1962 | 14470099 | Yes |
| 1910 | 3260 | 1630.0 | 104.1 | 52.0 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | False |
| 1911 | 3259 | 1629.5 | 77.4 | 38.7 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | False |
| 1912 | 3259 | 1629.5 | 67.1 | 33.5 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | False |
| 1913 | 4885 | 1628.3 | 162.8 | 54.3 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | False |
| 1914 | 1628 | 1628.0 | 46.9 | 46.9 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | False |
| 1915 | 1628 | 1628.0 | 43.8 | 43.8 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | False |
| 1916 | 1628 | 1628.0 | 30.3 | 30.3 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | False |
| 1917 | 3255 | 1627.5 | 76.6 | 38.3 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1918 | 1627 | 1627.0 | 58.1 | 58.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | False |
| 1919 | 1627 | 1627.0 | 34.1 | 34.1 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | False |
| 1920 | 3253 | 1626.5 | 92.4 | 46.2 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 1921 | 1626 | 1626.0 | 44.3 | 44.3 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | False |
| 1922 | 3251 | 1625.5 | 91.5 | 45.8 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1923 | 1625 | 1625.0 | 30.1 | 30.1 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | False |
| 1924 | 1625 | 1625.0 | 29.8 | 29.8 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | False |
| 1925 | 3250 | 1625.0 | 93.0 | 46.5 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | False |
| 1926 | 1624 | 1624.0 | 45.6 | 45.6 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 1927 | 1624 | 1624.0 | 28.4 | 28.4 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | False |
| 1928 | 1624 | 1624.0 | 63.9 | 63.9 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 1929 | 1624 | 1624.0 | 30.2 | 30.2 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | False |
| 1930 | 1623 | 1623.0 | 31.4 | 31.4 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1931 | 1622 | 1622.0 | 49.6 | 49.6 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | False |
| 1932 | 4866 | 1622.0 | 123.8 | 41.3 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | False |
| 1933 | 3244 | 1622.0 | 92.0 | 46.0 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | False |
| 1934 | 3241 | 1620.5 | 74.3 | 37.1 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1935 | 3241 | 1620.5 | 70.6 | 35.3 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | False |
| 1936 | 9722 | 1620.3 | 313.3 | 52.2 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 1937 | 1619 | 1619.0 | 112.0 | 112.0 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 1938 | 1619 | 1619.0 | 42.5 | 42.5 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1939 | 1619 | 1619.0 | 75.5 | 75.5 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1940 | 1619 | 1619.0 | 71.8 | 71.8 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | False |
| 1941 | 1619 | 1619.0 | 37.7 | 37.7 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | False |
| 1942 | 1618 | 1618.0 | 47.3 | 47.3 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | False |
| 1943 | 1618 | 1618.0 | 46.1 | 46.1 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | False |
| 1944 | 1618 | 1618.0 | 50.9 | 50.9 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | False |
| 1945 | 1618 | 1618.0 | 36.9 | 36.9 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | False |
| 1946 | 1618 | 1618.0 | 42.8 | 42.8 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | False |
| 1947 | 3235 | 1617.5 | 67.3 | 33.6 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | False |
| 1948 | 1617 | 1617.0 | 29.9 | 29.9 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | False |
| 1949 | 1616 | 1616.0 | 40.4 | 40.4 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | False |
| 1950 | 1616 | 1616.0 | 34.5 | 34.5 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | False |
| 1951 | 1616 | 1616.0 | 35.7 | 35.7 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | False |
| 1952 | 3231 | 1615.5 | 62.3 | 31.1 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 1953 | 1615 | 1615.0 | 29.3 | 29.3 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 1954 | 1615 | 1615.0 | 61.9 | 61.9 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | False |
| 1955 | 4844 | 1614.7 | 135.4 | 45.1 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 1956 | 1614 | 1614.0 | 91.9 | 91.9 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 1957 | 1613 | 1613.0 | 34.3 | 34.3 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | False |
| 1958 | 1613 | 1613.0 | 33.6 | 33.6 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | False |
| 1959 | 1612 | 1612.0 | 26.2 | 26.2 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | False |
| 1960 | 1612 | 1612.0 | 38.6 | 38.6 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 1961 | 3223 | 1611.5 | 65.4 | 32.7 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | False |
| 1962 | 3221 | 1610.5 | 78.1 | 39.0 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | False |
| 1963 | 4829 | 1609.7 | 115.4 | 38.5 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 1964 | 1609 | 1609.0 | 28.9 | 28.9 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | False |
| 1965 | 1609 | 1609.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W KUFFLER | J Neurophysiol | 1953 | 13035466 | Yes |
| 1966 | 3217 | 1608.5 | 81.2 | 40.6 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 1967 | 3217 | 1608.5 | 77.8 | 38.9 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 1968 | 1608 | 1608.0 | 52.2 | 52.2 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 1969 | 3216 | 1608.0 | 193.6 | 96.8 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 1970 | 1607 | 1607.0 | 52.2 | 52.2 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | False |
| 1971 | 1607 | 1607.0 | 29.4 | 29.4 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | False |
| 1972 | 4821 | 1607.0 | 131.3 | 43.8 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 1973 | 3212 | 1606.0 | 111.0 | 55.5 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 1974 | 4818 | 1606.0 | 53.5 | 17.8 | Improved method for the determination of blood glutathione. | E BEUTLER, O DURON, B M KELLY | J Lab Clin Med | 1963 | 13967893 | Yes |
| 1975 | 3211 | 1605.5 | 60.1 | 30.1 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 1976 | 1605 | 1605.0 | 56.2 | 56.2 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 1977 | 3209 | 1604.5 | 113.1 | 56.5 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 1978 | 3209 | 1604.5 | 88.1 | 44.0 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | False |
| 1979 | 1604 | 1604.0 | 29.3 | 29.3 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | False |
| 1980 | 1604 | 1604.0 | 19.5 | 19.5 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W CLELAND | Biochemistry | 1964 | 14192894 | Yes |
| 1981 | 3207 | 1603.5 | 61.0 | 30.5 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 1982 | 3207 | 1603.5 | 114.3 | 57.1 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | False |
| 1983 | 4810 | 1603.3 | 92.4 | 30.8 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 1984 | 9617 | 1602.8 | 277.5 | 46.2 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 1985 | 8012 | 1602.4 | 281.4 | 56.3 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 1986 | 1602 | 1602.0 | 36.1 | 36.1 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | False |
| 1987 | 3204 | 1602.0 | 91.4 | 45.7 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | False |
| 1988 | 1602 | 1602.0 | 51.9 | 51.9 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 1989 | 3202 | 1601.0 | 67.2 | 33.6 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | False |
| 1990 | 3202 | 1601.0 | 122.8 | 61.4 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | False |
| 1991 | 1600 | 1600.0 | 32.7 | 32.7 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | False |
| 1992 | 1600 | 1600.0 | 50.5 | 50.5 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 1993 | 1600 | 1600.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 1994 | 3200 | 1600.0 | 63.4 | 31.7 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 1995 | 1599 | 1599.0 | 39.4 | 39.4 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 1996 | 3198 | 1599.0 | 77.4 | 38.7 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 1997 | 1599 | 1599.0 | 118.2 | 118.2 | The changing landscape of atherosclerosis. | Peter Libby | Nature | 2021 | 33883728 | False |
| 1998 | 4795 | 1598.3 | 88.3 | 29.4 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | False |
| 1999 | 1598 | 1598.0 | 36.5 | 36.5 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | False |
| 2000 | 1598 | 1598.0 | 66.5 | 66.5 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 2001 | 1597 | 1597.0 | 31.3 | 31.3 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | False |
| 2002 | 3194 | 1597.0 | 57.2 | 28.6 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | False |
| 2003 | 15961 | 1596.1 | 374.7 | 37.5 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 2004 | 1596 | 1596.0 | 31.3 | 31.3 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | False |
| 2005 | 4785 | 1595.0 | 93.8 | 31.3 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 2006 | 1595 | 1595.0 | 50.6 | 50.6 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2007 | 3189 | 1594.5 | 92.5 | 46.2 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 2008 | 3189 | 1594.5 | 82.5 | 41.2 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | False |
| 2009 | 1594 | 1594.0 | 44.5 | 44.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 2010 | 1594 | 1594.0 | 34.1 | 34.1 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | False |
| 2011 | 4780 | 1593.3 | 173.1 | 57.7 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 2012 | 1593 | 1593.0 | 49.1 | 49.1 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 2013 | 1592 | 1592.0 | 49.5 | 49.5 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | False |
| 2014 | 1590 | 1590.0 | 35.2 | 35.2 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | False |
| 2015 | 3179 | 1589.5 | 62.8 | 31.4 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | False |
| 2016 | 7946 | 1589.2 | 153.4 | 30.7 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 2017 | 1589 | 1589.0 | 48.5 | 48.5 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 2018 | 1589 | 1589.0 | 42.8 | 42.8 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | False |
| 2019 | 3178 | 1589.0 | 90.3 | 45.1 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 2020 | 3177 | 1588.5 | 63.5 | 31.8 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | False |
| 2021 | 3176 | 1588.0 | 60.3 | 30.1 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 2022 | 1588 | 1588.0 | 49.9 | 49.9 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | False |
| 2023 | 3176 | 1588.0 | 77.3 | 38.6 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | False |
| 2024 | 3174 | 1587.0 | 96.2 | 48.1 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 2025 | 1586 | 1586.0 | 37.5 | 37.5 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 2026 | 3172 | 1586.0 | 77.7 | 38.9 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | False |
| 2027 | 1584 | 1584.0 | 62.1 | 62.1 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2028 | 1584 | 1584.0 | 33.9 | 33.9 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | False |
| 2029 | 3168 | 1584.0 | 76.6 | 38.3 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2030 | 4751 | 1583.7 | 121.1 | 40.4 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2031 | 3167 | 1583.5 | 101.0 | 50.5 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | False |
| 2032 | 3167 | 1583.5 | 127.4 | 63.7 | Interpreting findings from Mendelian randomization using the MR-Egger method. | Stephen Burgess, Simon G Thompson | Eur J Epidemiol | 2017 | 28527048 | Yes |
| 2033 | 1581 | 1581.0 | 35.2 | 35.2 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | False |
| 2034 | 3162 | 1581.0 | 115.7 | 57.9 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | False |
| 2035 | 6323 | 1580.8 | 203.0 | 50.8 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 2036 | 4742 | 1580.7 | 148.7 | 49.6 | SCANPY: large-scale single-cell gene expression data analysis. | F Alexander Wolf, Philipp Angerer, Fabian J Theis | Genome Biol | 2018 | 29409532 | Yes |
| 2037 | 1580 | 1580.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C HUMMEL | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 2038 | 6317 | 1579.2 | 209.8 | 52.5 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 2039 | 3158 | 1579.0 | 67.2 | 33.6 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2040 | 1579 | 1579.0 | 50.0 | 50.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2041 | 1579 | 1579.0 | 81.0 | 81.0 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2042 | 1579 | 1579.0 | 41.4 | 41.4 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | False |
| 2043 | 1579 | 1579.0 | 46.8 | 46.8 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2044 | 1579 | 1579.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H EAGLE | Science | 1955 | 13255879 | Yes |
| 2045 | 1579 | 1579.0 | 59.6 | 59.6 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | False |
| 2046 | 1578 | 1578.0 | 52.5 | 52.5 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | False |
| 2047 | 3156 | 1578.0 | 78.3 | 39.1 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2048 | 4734 | 1578.0 | 114.8 | 38.3 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | False |
| 2049 | 1578 | 1578.0 | 66.8 | 66.8 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | False |
| 2050 | 1577 | 1577.0 | 32.6 | 32.6 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 2051 | 3154 | 1577.0 | 61.7 | 30.9 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | False |
| 2052 | 1577 | 1577.0 | 58.3 | 58.3 | Inflammation, metaflammation and immunometabolic disorders. | Gökhan S Hotamisligil | Nature | 2017 | 28179656 | False |
| 2053 | 1575 | 1575.0 | 31.3 | 31.3 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | False |
| 2054 | 1575 | 1575.0 | 33.2 | 33.2 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | False |
| 2055 | 3149 | 1574.5 | 71.9 | 36.0 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | False |
| 2056 | 1574 | 1574.0 | 65.1 | 65.1 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | False |
| 2057 | 3147 | 1573.5 | 104.8 | 52.4 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2058 | 1573 | 1573.0 | 79.4 | 79.4 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 2059 | 1573 | 1573.0 | 44.9 | 44.9 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | False |
| 2060 | 4717 | 1572.3 | 156.0 | 52.0 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | False |
| 2061 | 1572 | 1572.0 | 46.2 | 46.2 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | False |
| 2062 | 20408 | 1569.8 | 514.3 | 39.6 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2063 | 1568 | 1568.0 | 41.0 | 41.0 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | False |
| 2064 | 1567 | 1567.0 | 45.0 | 45.0 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | False |
| 2065 | 1567 | 1567.0 | 80.6 | 80.6 | Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. | Cynthia Rudin | Nat Mach Intell | 2019 | 35603010 | Yes |
| 2066 | 1566 | 1566.0 | 58.8 | 58.8 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | False |
| 2067 | 1566 | 1566.0 | 42.5 | 42.5 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | False |
| 2068 | 12521 | 1565.1 | 305.9 | 38.2 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2069 | 1565 | 1565.0 | 47.2 | 47.2 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 2070 | 1565 | 1565.0 | 84.2 | 84.2 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | False |
| 2071 | 1564 | 1564.0 | 38.8 | 38.8 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2072 | 1564 | 1564.0 | 39.0 | 39.0 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | False |
| 2073 | 1564 | 1564.0 | 32.7 | 32.7 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | False |
| 2074 | 3127 | 1563.5 | 79.7 | 39.9 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 2075 | 6250 | 1562.5 | 118.9 | 29.7 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2076 | 6249 | 1562.2 | 154.2 | 38.5 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2077 | 6249 | 1562.2 | 205.5 | 51.4 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 2078 | 1561 | 1561.0 | 55.5 | 55.5 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | False |
| 2079 | 1561 | 1561.0 | 38.4 | 38.4 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | False |
| 2080 | 1561 | 1561.0 | 40.9 | 40.9 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | False |
| 2081 | 1561 | 1561.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 2082 | 1561 | 1561.0 | 51.3 | 51.3 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | False |
| 2083 | 3121 | 1560.5 | 21.7 | 10.8 | Junctional complexes in various epithelia. | M G FARQUHAR, G E PALADE | J Cell Biol | 1963 | 13944428 | Yes |
| 2084 | 10921 | 1560.1 | 259.7 | 37.1 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 2085 | 1560 | 1560.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L WELCH | Biometrika | 1947 | 20287819 | Yes |
| 2086 | 3117 | 1558.5 | 38.5 | 19.2 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 2087 | 4675 | 1558.3 | 128.5 | 42.8 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | False |
| 2088 | 4669 | 1556.3 | 140.6 | 46.9 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2089 | 1556 | 1556.0 | 56.7 | 56.7 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2090 | 3112 | 1556.0 | 67.9 | 34.0 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | False |
| 2091 | 4666 | 1555.3 | 91.4 | 30.5 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2092 | 4665 | 1555.0 | 103.0 | 34.3 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 2093 | 1553 | 1553.0 | 44.4 | 44.4 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | False |
| 2094 | 6208 | 1552.0 | 148.3 | 37.1 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2095 | 1552 | 1552.0 | 44.7 | 44.7 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2096 | 1551 | 1551.0 | 53.2 | 53.2 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | False |
| 2097 | 1551 | 1551.0 | 43.7 | 43.7 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | False |
| 2098 | 1551 | 1551.0 | 53.8 | 53.8 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2099 | 1551 | 1551.0 | 28.0 | 28.0 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | False |
| 2100 | 6204 | 1551.0 | 269.7 | 67.4 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 2101 | 7754 | 1550.8 | 336.7 | 67.3 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 2102 | 1550 | 1550.0 | 43.5 | 43.5 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2103 | 6199 | 1549.8 | 256.2 | 64.0 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | False |
| 2104 | 6193 | 1548.2 | 178.3 | 44.6 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2105 | 1548 | 1548.0 | 44.8 | 44.8 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 2106 | 1548 | 1548.0 | 33.0 | 33.0 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | False |
| 2107 | 1548 | 1548.0 | 31.3 | 31.3 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | False |
| 2108 | 1548 | 1548.0 | 36.8 | 36.8 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | False |
| 2109 | 1547 | 1547.0 | 59.7 | 59.7 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2110 | 1547 | 1547.0 | 42.4 | 42.4 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | False |
| 2111 | 4634 | 1544.7 | 149.2 | 49.7 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graça Raposo, Clotilde Théry | Annu Rev Cell Dev Biol | 2014 | 25288114 | False |
| 2112 | 4632 | 1544.0 | 89.2 | 29.7 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 2113 | 1544 | 1544.0 | 41.7 | 41.7 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | False |
| 2114 | 1543 | 1543.0 | 42.8 | 42.8 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | False |
| 2115 | 1543 | 1543.0 | 57.6 | 57.6 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2116 | 3085 | 1542.5 | 71.1 | 35.5 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 2117 | 3085 | 1542.5 | 95.0 | 47.5 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | False |
| 2118 | 3084 | 1542.0 | 99.4 | 49.7 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | False |
| 2119 | 1542 | 1542.0 | 36.1 | 36.1 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | False |
| 2120 | 3084 | 1542.0 | 117.6 | 58.8 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | False |
| 2121 | 3083 | 1541.5 | 60.1 | 30.1 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | False |
| 2122 | 1541 | 1541.0 | 91.4 | 91.4 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2123 | 1541 | 1541.0 | 33.8 | 33.8 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2124 | 1541 | 1541.0 | 31.8 | 31.8 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | False |
| 2125 | 3082 | 1541.0 | 98.9 | 49.5 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | False |
| 2126 | 4623 | 1541.0 | 344.8 | 114.9 | Ferroptosis: mechanisms, biology and role in disease. | Xuejun Jiang, Brent R Stockwell, Marcus Conrad | Nat Rev Mol Cell Biol | 2021 | 33495651 | False |
| 2127 | 10783 | 1540.4 | 227.1 | 32.4 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2128 | 1539 | 1539.0 | 32.6 | 32.6 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | False |
| 2129 | 1538 | 1538.0 | 30.0 | 30.0 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2130 | 1538 | 1538.0 | 18.8 | 18.8 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2131 | 1537 | 1537.0 | 45.8 | 45.8 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | False |
| 2132 | 3074 | 1537.0 | 88.8 | 44.4 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | False |
| 2133 | 3074 | 1537.0 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G SCHMIDT, S J THANNHAUSER | J Biol Chem | 1945 | 21005717 | Yes |
| 2134 | 1536 | 1536.0 | 57.7 | 57.7 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2135 | 1536 | 1536.0 | 52.7 | 52.7 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | False |
| 2136 | 4607 | 1535.7 | 96.5 | 32.2 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | False |
| 2137 | 3071 | 1535.5 | 88.4 | 44.2 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | False |
| 2138 | 1535 | 1535.0 | 68.1 | 68.1 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2139 | 1535 | 1535.0 | 39.4 | 39.4 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | False |
| 2140 | 1535 | 1535.0 | 56.9 | 56.9 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
| 2141 | 3069 | 1534.5 | 95.7 | 47.9 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | False |
| 2142 | 3069 | 1534.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
| 2143 | 1534 | 1534.0 | 37.5 | 37.5 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2144 | 1533 | 1533.0 | 57.0 | 57.0 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2145 | 1533 | 1533.0 | 40.2 | 40.2 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2146 | 1533 | 1533.0 | 41.1 | 41.1 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | False |
| 2147 | 4597 | 1532.3 | 110.1 | 36.7 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | False |
| 2148 | 3064 | 1532.0 | 99.0 | 49.5 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | False |
| 2149 | 3061 | 1530.5 | 66.7 | 33.4 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | False |
| 2150 | 4591 | 1530.3 | 154.5 | 51.5 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2151 | 1530 | 1530.0 | 33.4 | 33.4 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | False |
| 2152 | 1530 | 1530.0 | 41.0 | 41.0 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | False |
| 2153 | 1530 | 1530.0 | 50.3 | 50.3 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2154 | 1530 | 1530.0 | 50.2 | 50.2 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2155 | 1529 | 1529.0 | 21.3 | 21.3 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2156 | 1529 | 1529.0 | 33.2 | 33.2 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | False |
| 2157 | 1528 | 1528.0 | 45.5 | 45.5 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2158 | 1528 | 1528.0 | 48.1 | 48.1 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2159 | 1528 | 1528.0 | 31.4 | 31.4 | Antigen-Antibody Crossed Electrophoresis. | C B LAURELL | Anal Biochem | 1965 | 14302464 | Yes |
| 2160 | 1526 | 1526.0 | 12.4 | 12.4 | The Relation Of Recombination To Mutational Advance. | H J MULLER | Mutat Res | 1964 | 14195748 | Yes |
| 2161 | 1526 | 1526.0 | 45.8 | 45.8 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2162 | 1524 | 1524.0 | 97.4 | 97.4 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2163 | 4572 | 1524.0 | 93.6 | 31.2 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | False |
| 2164 | 1523 | 1523.0 | 45.2 | 45.2 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2165 | 1523 | 1523.0 | 38.7 | 38.7 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | False |
| 2166 | 1523 | 1523.0 | 44.6 | 44.6 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2167 | 3046 | 1523.0 | 60.0 | 30.0 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | False |
| 2168 | 1523 | 1523.0 | 48.1 | 48.1 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | False |
| 2169 | 1523 | 1523.0 | 29.2 | 29.2 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L RAMANATHAN | J Appl Physiol | 1964 | 14173555 | Yes |
| 2170 | 1523 | 1523.0 | 35.4 | 35.4 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | False |
| 2171 | 4567 | 1522.3 | 165.7 | 55.2 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2172 | 3044 | 1522.0 | 95.2 | 47.6 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 2173 | 1522 | 1522.0 | 54.0 | 54.0 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 2174 | 1521 | 1521.0 | 32.2 | 32.2 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2175 | 1521 | 1521.0 | 43.5 | 43.5 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2176 | 1521 | 1521.0 | 34.0 | 34.0 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | False |
| 2177 | 1521 | 1521.0 | 45.6 | 45.6 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | False |
| 2178 | 6083 | 1520.8 | 130.4 | 32.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2179 | 4559 | 1519.7 | 141.4 | 47.1 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2180 | 1519 | 1519.0 | 26.5 | 26.5 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | False |
| 2181 | 1519 | 1519.0 | 40.9 | 40.9 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | False |
| 2182 | 1517 | 1517.0 | 40.0 | 40.0 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2183 | 1517 | 1517.0 | 37.9 | 37.9 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | False |
| 2184 | 3034 | 1517.0 | 90.0 | 45.0 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2185 | 1517 | 1517.0 | 35.2 | 35.2 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | False |
| 2186 | 1516 | 1516.0 | 26.9 | 26.9 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2187 | 3032 | 1516.0 | 58.6 | 29.3 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | False |
| 2188 | 4548 | 1516.0 | 158.4 | 52.8 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | False |
| 2189 | 1515 | 1515.0 | 57.3 | 57.3 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2190 | 1515 | 1515.0 | 39.8 | 39.8 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2191 | 4542 | 1514.0 | 101.7 | 33.9 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | False |
| 2192 | 1512 | 1512.0 | 42.6 | 42.6 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2193 | 1512 | 1512.0 | 45.2 | 45.2 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | False |
| 2194 | 6048 | 1512.0 | 238.5 | 59.6 | Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. | Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess | Genet Epidemiol | 2016 | 27061298 | Yes |
| 2195 | 3022 | 1511.0 | 58.5 | 29.2 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | False |
| 2196 | 1510 | 1510.0 | 49.5 | 49.5 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2197 | 1510 | 1510.0 | 37.3 | 37.3 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | False |
| 2198 | 1510 | 1510.0 | 76.6 | 76.6 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | False |
| 2199 | 3019 | 1509.5 | 102.7 | 51.4 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2200 | 1509 | 1509.0 | 40.5 | 40.5 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | False |
| 2201 | 1509 | 1509.0 | 96.7 | 96.7 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2202 | 1509 | 1509.0 | 22.2 | 22.2 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2203 | 4527 | 1509.0 | 108.0 | 36.0 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2204 | 4527 | 1509.0 | 104.0 | 34.7 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | False |
| 2205 | 4525 | 1508.3 | 97.1 | 32.4 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2206 | 1508 | 1508.0 | 33.6 | 33.6 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2207 | 1508 | 1508.0 | 25.6 | 25.6 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K FUXE | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2208 | 3015 | 1507.5 | 84.7 | 42.4 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2209 | 3014 | 1507.0 | 92.8 | 46.4 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | False |
| 2210 | 1507 | 1507.0 | 38.4 | 38.4 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | False |
| 2211 | 1507 | 1507.0 | 36.2 | 36.2 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | False |
| 2212 | 1506 | 1506.0 | 49.2 | 49.2 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | False |
| 2213 | 4517 | 1505.7 | 259.9 | 86.6 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A WINTER, E A RISLEY, G W NUSS | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2214 | 3011 | 1505.5 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F WROBLEWSKI, J S LADUE | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2215 | 1505 | 1505.0 | 19.1 | 19.1 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2216 | 1505 | 1505.0 | 46.6 | 46.6 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | False |
| 2217 | 1505 | 1505.0 | 38.4 | 38.4 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2218 | 1505 | 1505.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2219 | 4514 | 1504.7 | 258.6 | 86.2 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 2220 | 3009 | 1504.5 | 61.8 | 30.9 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | False |
| 2221 | 1504 | 1504.0 | 44.5 | 44.5 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | False |
| 2222 | 3008 | 1504.0 | 86.6 | 43.3 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | False |
| 2223 | 3002 | 1501.0 | 98.5 | 49.2 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2224 | 1501 | 1501.0 | 50.1 | 50.1 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2225 | 3002 | 1501.0 | 100.6 | 50.3 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | False |
| 2226 | 1501 | 1501.0 | 42.3 | 42.3 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | False |
| 2227 | 3001 | 1500.5 | 184.2 | 92.1 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. | Helmut Sies, Dean P Jones | Nat Rev Mol Cell Biol | 2020 | 32231263 | False |
| 2228 | 1500 | 1500.0 | 32.8 | 32.8 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | False |
| 2229 | 1500 | 1500.0 | 51.9 | 51.9 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | False |
| 2230 | 1500 | 1500.0 | 17.8 | 17.8 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | False |
| 2231 | 1499 | 1499.0 | 43.2 | 43.2 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | False |
| 2232 | 2997 | 1498.5 | 56.7 | 28.4 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | False |
| 2233 | 2997 | 1498.5 | 56.5 | 28.2 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | False |
| 2234 | 2997 | 1498.5 | 77.4 | 38.7 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | False |
| 2235 | 1498 | 1498.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B MOUNTCASTLE | J Neurophysiol | 1957 | 13439410 | Yes |
| 2236 | 1498 | 1498.0 | 43.8 | 43.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | False |
| 2237 | 1498 | 1498.0 | 63.6 | 63.6 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 2238 | 1497 | 1497.0 | 8.0 | 8.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W SPERRY | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2239 | 4490 | 1496.7 | 122.8 | 40.9 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2240 | 10473 | 1496.1 | 342.6 | 48.9 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 2241 | 1496 | 1496.0 | 48.2 | 48.2 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | False |
| 2242 | 1496 | 1496.0 | 58.8 | 58.8 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2243 | 1495 | 1495.0 | 46.0 | 46.0 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | False |
| 2244 | 1493 | 1493.0 | 34.3 | 34.3 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | False |
| 2245 | 1493 | 1493.0 | 37.8 | 37.8 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | False |
| 2246 | 2986 | 1493.0 | 69.9 | 35.0 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2247 | 1493 | 1493.0 | 37.6 | 37.6 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | False |
| 2248 | 1492 | 1492.0 | 38.2 | 38.2 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | False |
| 2249 | 1492 | 1492.0 | 28.5 | 28.5 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | False |
| 2250 | 1492 | 1492.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2251 | 1492 | 1492.0 | 51.4 | 51.4 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | False |
| 2252 | 1491 | 1491.0 | 39.0 | 39.0 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | False |
| 2253 | 1491 | 1491.0 | 62.6 | 62.6 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | False |
| 2254 | 1490 | 1490.0 | 36.3 | 36.3 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | False |
| 2255 | 1490 | 1490.0 | 36.4 | 36.4 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2256 | 1490 | 1490.0 | 31.6 | 31.6 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | False |
| 2257 | 1490 | 1490.0 | 33.2 | 33.2 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | False |
| 2258 | 2979 | 1489.5 | 70.6 | 35.3 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | False |
| 2259 | 1489 | 1489.0 | 33.7 | 33.7 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | False |
| 2260 | 2978 | 1489.0 | 67.6 | 33.8 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | False |
| 2261 | 4467 | 1489.0 | 45.9 | 15.3 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T DODGE, C MITCHELL, D J HANAHAN | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2262 | 1489 | 1489.0 | 40.0 | 40.0 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | False |
| 2263 | 7438 | 1487.6 | 261.3 | 52.3 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 2264 | 2975 | 1487.5 | 94.7 | 47.4 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | False |
| 2265 | 1487 | 1487.0 | 50.3 | 50.3 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2266 | 1486 | 1486.0 | 36.7 | 36.7 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | False |
| 2267 | 2972 | 1486.0 | 75.4 | 37.7 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | False |
| 2268 | 1485 | 1485.0 | 53.2 | 53.2 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2269 | 1485 | 1485.0 | 33.2 | 33.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2270 | 1485 | 1485.0 | 39.1 | 39.1 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | False |
| 2271 | 1485 | 1485.0 | 41.7 | 41.7 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | False |
| 2272 | 5937 | 1484.2 | 248.3 | 62.1 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2273 | 1484 | 1484.0 | 34.8 | 34.8 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2274 | 1484 | 1484.0 | 26.3 | 26.3 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2275 | 1484 | 1484.0 | 25.3 | 25.3 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | False |
| 2276 | 1484 | 1484.0 | 40.9 | 40.9 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | False |
| 2277 | 1483 | 1483.0 | 40.5 | 40.5 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | False |
| 2278 | 13343 | 1482.6 | 409.0 | 45.4 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2279 | 2965 | 1482.5 | 75.1 | 37.5 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2280 | 1481 | 1481.0 | 38.4 | 38.4 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | False |
| 2281 | 1481 | 1481.0 | 52.3 | 52.3 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2282 | 5919 | 1479.8 | 138.9 | 34.7 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | False |
| 2283 | 2956 | 1478.0 | 68.2 | 34.1 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | False |
| 2284 | 1478 | 1478.0 | 31.6 | 31.6 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | False |
| 2285 | 1478 | 1478.0 | 30.4 | 30.4 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | False |
| 2286 | 1478 | 1478.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2287 | 1478 | 1478.0 | 51.2 | 51.2 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2288 | 1478 | 1478.0 | 34.3 | 34.3 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | False |
| 2289 | 4431 | 1477.0 | 146.0 | 48.7 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2290 | 1477 | 1477.0 | 10.7 | 10.7 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E HUXLEY | J Mol Biol | 1963 | 14064165 | Yes |
| 2291 | 1477 | 1477.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E SATTERTHWAITE | Biometrics | 1946 | 20287815 | Yes |
| 2292 | 1476 | 1476.0 | 34.3 | 34.3 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C NOWELL | Cancer Res | 1960 | 14427849 | Yes |
| 2293 | 2951 | 1475.5 | 76.1 | 38.0 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | False |
| 2294 | 2950 | 1475.0 | 95.9 | 48.0 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2295 | 1475 | 1475.0 | 35.4 | 35.4 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2296 | 2949 | 1474.5 | 67.9 | 34.0 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | False |
| 2297 | 1474 | 1474.0 | 42.9 | 42.9 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | False |
| 2298 | 1474 | 1474.0 | 33.6 | 33.6 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | False |
| 2299 | 2948 | 1474.0 | 77.8 | 38.9 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | False |
| 2300 | 2947 | 1473.5 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2301 | 2947 | 1473.5 | 170.5 | 85.2 | Osteoarthritis. | David J Hunter, Sita Bierma-Zeinstra | Lancet | 2019 | 31034380 | False |
| 2302 | 4420 | 1473.3 | 95.9 | 32.0 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2303 | 2946 | 1473.0 | 157.6 | 78.8 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G GRAY, V P WHITTAKER | J Anat | 1962 | 13901297 | Yes |
| 2304 | 2945 | 1472.5 | 78.0 | 39.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2305 | 2945 | 1472.5 | 91.9 | 46.0 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | False |
| 2306 | 1471 | 1471.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H ROSEN | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2307 | 2942 | 1471.0 | 67.4 | 33.7 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | False |
| 2308 | 1470 | 1470.0 | 53.3 | 53.3 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2309 | 1470 | 1470.0 | 49.6 | 49.6 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | False |
| 2310 | 2939 | 1469.5 | 112.3 | 56.1 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | Yes |
| 2311 | 1469 | 1469.0 | 30.4 | 30.4 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2312 | 1469 | 1469.0 | 47.8 | 47.8 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2313 | 1469 | 1469.0 | 54.5 | 54.5 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | False |
| 2314 | 1469 | 1469.0 | 30.1 | 30.1 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | False |
| 2315 | 1469 | 1469.0 | 33.4 | 33.4 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | False |
| 2316 | 2936 | 1468.0 | 96.6 | 48.3 | Nitric oxide synthases: regulation and function. | Ulrich Förstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | False |
| 2317 | 2935 | 1467.5 | 97.6 | 48.8 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2318 | 2934 | 1467.0 | 153.2 | 76.6 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2319 | 7335 | 1467.0 | 266.1 | 53.2 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | False |
| 2320 | 1466 | 1466.0 | 37.9 | 37.9 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2321 | 1466 | 1466.0 | 30.7 | 30.7 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | False |
| 2322 | 2932 | 1466.0 | 88.4 | 44.2 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2323 | 1464 | 1464.0 | 33.5 | 33.5 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J KARNOVSKY | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2324 | 2927 | 1463.5 | 96.7 | 48.4 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | False |
| 2325 | 1463 | 1463.0 | 34.4 | 34.4 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2326 | 1463 | 1463.0 | 38.3 | 38.3 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2327 | 1463 | 1463.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2328 | 1463 | 1463.0 | 38.7 | 38.7 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | False |
| 2329 | 1462 | 1462.0 | 44.2 | 44.2 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2330 | 2922 | 1461.0 | 54.0 | 27.0 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | False |
| 2331 | 1461 | 1461.0 | 25.7 | 25.7 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | False |
| 2332 | 1460 | 1460.0 | 36.4 | 36.4 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | False |
| 2333 | 2920 | 1460.0 | 55.2 | 27.6 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | False |
| 2334 | 2920 | 1460.0 | 81.4 | 40.7 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2335 | 1459 | 1459.0 | 20.8 | 20.8 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2336 | 1459 | 1459.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E BUSH | Biochem J | 1952 | 14915960 | Yes |
| 2337 | 1459 | 1459.0 | 41.6 | 41.6 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2338 | 2918 | 1459.0 | 63.3 | 31.6 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | False |
| 2339 | 2916 | 1458.0 | 99.7 | 49.9 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2340 | 2916 | 1458.0 | 86.0 | 43.0 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | False |
| 2341 | 4372 | 1457.3 | 92.4 | 30.8 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | False |
| 2342 | 1457 | 1457.0 | 60.1 | 60.1 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | False |
| 2343 | 2914 | 1457.0 | 106.4 | 53.2 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | False |
| 2344 | 2912 | 1456.0 | 54.9 | 27.4 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | False |
| 2345 | 2910 | 1455.0 | 85.7 | 42.9 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2346 | 1455 | 1455.0 | 40.1 | 40.1 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2347 | 2909 | 1454.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H CLARKE, J CASALS | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2348 | 1454 | 1454.0 | 35.6 | 35.6 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2349 | 4361 | 1453.7 | 94.4 | 31.5 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2350 | 2907 | 1453.5 | 72.1 | 36.0 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2351 | 1453 | 1453.0 | 33.4 | 33.4 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | False |
| 2352 | 1453 | 1453.0 | 29.1 | 29.1 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | False |
| 2353 | 1453 | 1453.0 | 36.3 | 36.3 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | False |
| 2354 | 2906 | 1453.0 | 330.2 | 165.1 | Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. | Luke A McGuinness, Julian P T Higgins | Res Synth Methods | 2021 | 32336025 | Yes |
| 2355 | 5811 | 1452.8 | 263.9 | 66.0 | Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do | Nat Genet | 2018 | 29686387 | Yes |
| 2356 | 2905 | 1452.5 | 62.6 | 31.3 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | False |
| 2357 | 4357 | 1452.3 | 150.6 | 50.2 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2358 | 2904 | 1452.0 | 57.3 | 28.6 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2359 | 2903 | 1451.5 | 79.5 | 39.8 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2360 | 2903 | 1451.5 | 81.0 | 40.5 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | False |
| 2361 | 7252 | 1450.4 | 168.7 | 33.7 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2362 | 4351 | 1450.3 | 86.1 | 28.7 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | False |
| 2363 | 2900 | 1450.0 | 75.0 | 37.5 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 2364 | 1450 | 1450.0 | 31.3 | 31.3 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | False |
| 2365 | 1450 | 1450.0 | 43.0 | 43.0 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2366 | 1449 | 1449.0 | 48.3 | 48.3 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2367 | 1449 | 1449.0 | 34.9 | 34.9 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2368 | 1449 | 1449.0 | 41.3 | 41.3 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2369 | 2896 | 1448.0 | 66.6 | 33.3 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | False |
| 2370 | 2895 | 1447.5 | 78.3 | 39.1 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | False |
| 2371 | 2895 | 1447.5 | 65.8 | 32.9 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2372 | 2895 | 1447.5 | 80.0 | 40.0 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2373 | 2895 | 1447.5 | 80.6 | 40.3 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marçais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 2374 | 2894 | 1447.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A ISAACS, J LINDENMANN | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2375 | 4341 | 1447.0 | 134.8 | 44.9 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2376 | 5786 | 1446.5 | 152.7 | 38.2 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2377 | 2893 | 1446.5 | 62.7 | 31.4 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2378 | 2893 | 1446.5 | 105.9 | 53.0 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | False |
| 2379 | 7230 | 1446.0 | 204.5 | 40.9 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2380 | 1446 | 1446.0 | 29.0 | 29.0 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | False |
| 2381 | 2892 | 1446.0 | 98.6 | 49.3 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | False |
| 2382 | 1446 | 1446.0 | 42.0 | 42.0 | Function and information content of DNA methylation. | Dirk Schübeler | Nature | 2015 | 25592537 | False |
| 2383 | 2891 | 1445.5 | 75.9 | 38.0 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | False |
| 2384 | 10118 | 1445.4 | 402.9 | 57.6 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2385 | 4335 | 1445.0 | 89.1 | 29.7 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | False |
| 2386 | 2889 | 1444.5 | 52.7 | 26.4 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | False |
| 2387 | 2889 | 1444.5 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D DAVIS, E S MINGIOLI | J Bacteriol | 1950 | 15436457 | Yes |
| 2388 | 1444 | 1444.0 | 36.3 | 36.3 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | False |
| 2389 | 2888 | 1444.0 | 70.8 | 35.4 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2390 | 1444 | 1444.0 | 32.7 | 32.7 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | False |
| 2391 | 1444 | 1444.0 | 41.1 | 41.1 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2392 | 2887 | 1443.5 | 70.3 | 35.1 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2393 | 2887 | 1443.5 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J BLOOM, W W RICHARDSON | Br J Cancer | 1957 | 13499785 | Yes |
| 2394 | 7217 | 1443.4 | 154.8 | 31.0 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2395 | 1443 | 1443.0 | 31.4 | 31.4 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | False |
| 2396 | 4328 | 1442.7 | 92.3 | 30.8 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2397 | 2885 | 1442.5 | 84.6 | 42.3 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2398 | 1442 | 1442.0 | 85.0 | 85.0 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2399 | 1442 | 1442.0 | 70.9 | 70.9 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2400 | 8651 | 1441.8 | 258.9 | 43.1 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdóttir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 2401 | 4325 | 1441.7 | 108.1 | 36.0 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2402 | 2883 | 1441.5 | 174.8 | 87.4 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H ANTON, D F SAYRE | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2403 | 1440 | 1440.0 | 36.9 | 36.9 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | False |
| 2404 | 1440 | 1440.0 | 31.0 | 31.0 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2405 | 1440 | 1440.0 | 27.4 | 27.4 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | False |
| 2406 | 2880 | 1440.0 | 67.9 | 34.0 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | False |
| 2407 | 1440 | 1440.0 | 44.4 | 44.4 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | False |
| 2408 | 4318 | 1439.3 | 114.4 | 38.1 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2409 | 4317 | 1439.0 | 86.7 | 28.9 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | False |
| 2410 | 1439 | 1439.0 | 42.2 | 42.2 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2411 | 2878 | 1439.0 | 234.4 | 117.2 | Gut microbiota in human metabolic health and disease. | Yong Fan, Oluf Pedersen | Nat Rev Microbiol | 2021 | 32887946 | False |
| 2412 | 2877 | 1438.5 | 66.0 | 33.0 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | False |
| 2413 | 4312 | 1437.3 | 202.6 | 67.5 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2414 | 1436 | 1436.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D POULIK | Nature | 1957 | 13493570 | Yes |
| 2415 | 1436 | 1436.0 | 39.5 | 39.5 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2416 | 5743 | 1435.8 | 204.7 | 51.2 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2417 | 1435 | 1435.0 | 33.1 | 33.1 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2418 | 2870 | 1435.0 | 101.7 | 50.9 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2419 | 1434 | 1434.0 | 46.8 | 46.8 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2420 | 2868 | 1434.0 | 70.4 | 35.2 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2421 | 5736 | 1434.0 | 293.3 | 73.3 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 2422 | 8601 | 1433.5 | 212.3 | 35.4 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2423 | 2866 | 1433.0 | 80.3 | 40.1 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2424 | 2864 | 1432.0 | 70.1 | 35.0 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2425 | 1432 | 1432.0 | 26.5 | 26.5 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | False |
| 2426 | 1432 | 1432.0 | 16.6 | 16.6 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J WYMAN | Adv Protein Chem | 1964 | 14268785 | False |
| 2427 | 1432 | 1432.0 | 34.4 | 34.4 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | False |
| 2428 | 1432 | 1432.0 | 61.0 | 61.0 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | False |
| 2429 | 2863 | 1431.5 | 71.2 | 35.6 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2430 | 1431 | 1431.0 | 30.8 | 30.8 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2431 | 1430 | 1430.0 | 17.0 | 17.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2432 | 1430 | 1430.0 | 67.3 | 67.3 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2433 | 1430 | 1430.0 | 43.1 | 43.1 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | False |
| 2434 | 4290 | 1430.0 | 99.5 | 33.2 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2435 | 1430 | 1430.0 | 33.2 | 33.2 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | False |
| 2436 | 1430 | 1430.0 | 57.3 | 57.3 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | False |
| 2437 | 1429 | 1429.0 | 46.1 | 46.1 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2438 | 2857 | 1428.5 | 59.1 | 29.6 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | False |
| 2439 | 4284 | 1428.0 | 139.6 | 46.5 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2440 | 1428 | 1428.0 | 33.1 | 33.1 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | False |
| 2441 | 1428 | 1428.0 | 34.2 | 34.2 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | False |
| 2442 | 1428 | 1428.0 | 46.5 | 46.5 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | False |
| 2443 | 2854 | 1427.0 | 83.0 | 41.5 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | False |
| 2444 | 1427 | 1427.0 | 0.0 | 0.0 | The critical incident technique. | J C FLANAGAN | Psychol Bull | 1954 | 13177800 | Yes |
| 2445 | 1427 | 1427.0 | 29.6 | 29.6 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2446 | 7133 | 1426.6 | 266.8 | 53.4 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2447 | 1426 | 1426.0 | 53.8 | 53.8 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2448 | 8556 | 1426.0 | 306.6 | 51.1 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2449 | 2851 | 1425.5 | 77.6 | 38.8 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | False |
| 2450 | 2850 | 1425.0 | 36.4 | 18.2 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A DAHLSTROEM, K FUXE | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2451 | 1425 | 1425.0 | 12.8 | 12.8 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2452 | 1425 | 1425.0 | 39.0 | 39.0 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | False |
| 2453 | 1424 | 1424.0 | 50.4 | 50.4 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2454 | 1424 | 1424.0 | 58.4 | 58.4 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2455 | 2847 | 1423.5 | 88.8 | 44.4 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2456 | 4270 | 1423.3 | 128.6 | 42.9 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | False |
| 2457 | 1423 | 1423.0 | 29.2 | 29.2 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2458 | 1423 | 1423.0 | 40.1 | 40.1 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | False |
| 2459 | 2845 | 1422.5 | 77.3 | 38.6 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | False |
| 2460 | 2845 | 1422.5 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L HODGKIN, B KATZ | J Physiol | 1949 | 18128147 | Yes |
| 2461 | 2844 | 1422.0 | 66.1 | 33.0 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | False |
| 2462 | 1422 | 1422.0 | 44.7 | 44.7 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2463 | 1422 | 1422.0 | 30.4 | 30.4 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | False |
| 2464 | 4264 | 1421.3 | 107.7 | 35.9 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | False |
| 2465 | 2842 | 1421.0 | 114.4 | 57.2 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2466 | 1421 | 1421.0 | 53.9 | 53.9 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2467 | 22734 | 1420.9 | 614.4 | 38.4 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | False |
| 2468 | 1420 | 1420.0 | 36.4 | 36.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2469 | 4259 | 1419.7 | 111.0 | 37.0 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | False |
| 2470 | 1419 | 1419.0 | 34.9 | 34.9 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2471 | 1419 | 1419.0 | 26.9 | 26.9 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | False |
| 2472 | 4256 | 1418.7 | 156.7 | 52.2 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 2473 | 1418 | 1418.0 | 28.0 | 28.0 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2474 | 2835 | 1417.5 | 81.0 | 40.5 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2475 | 2834 | 1417.0 | 70.1 | 35.0 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | False |
| 2476 | 1417 | 1417.0 | 28.0 | 28.0 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | False |
| 2477 | 1417 | 1417.0 | 36.5 | 36.5 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | False |
| 2478 | 1416 | 1416.0 | 50.9 | 50.9 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | False |
| 2479 | 1416 | 1416.0 | 24.4 | 24.4 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | False |
| 2480 | 2832 | 1416.0 | 95.5 | 47.8 | A new scale of social desirability independent of psychopathology. | D P CROWNE, D MARLOWE | J Consult Psychol | 1960 | 13813058 | Yes |
| 2481 | 2829 | 1414.5 | 66.8 | 33.4 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | False |
| 2482 | 1414 | 1414.0 | 25.2 | 25.2 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2483 | 1414 | 1414.0 | 31.6 | 31.6 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2484 | 2828 | 1414.0 | 82.8 | 41.4 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2485 | 1413 | 1413.0 | 33.3 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | False |
| 2486 | 1413 | 1413.0 | 31.3 | 31.3 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | False |
| 2487 | 4239 | 1413.0 | 92.2 | 30.7 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | False |
| 2488 | 1413 | 1413.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F ROSENBLATT | Psychol Rev | 1958 | 13602029 | Yes |
| 2489 | 2825 | 1412.5 | 58.1 | 29.1 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | False |
| 2490 | 1412 | 1412.0 | 28.9 | 28.9 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | False |
| 2491 | 1411 | 1411.0 | 36.8 | 36.8 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | False |
| 2492 | 2821 | 1410.5 | 71.1 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2493 | 4231 | 1410.3 | 117.1 | 39.0 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2494 | 8460 | 1410.0 | 205.9 | 34.3 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2495 | 2819 | 1409.5 | 42.4 | 21.2 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2496 | 2819 | 1409.5 | 65.9 | 33.0 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | False |
| 2497 | 2818 | 1409.0 | 82.4 | 41.2 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2498 | 1409 | 1409.0 | 29.2 | 29.2 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | False |
| 2499 | 2817 | 1408.5 | 98.5 | 49.2 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2500 | 2816 | 1408.0 | 81.4 | 40.7 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | False |
| 2501 | 1408 | 1408.0 | 35.8 | 35.8 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2502 | 1408 | 1408.0 | 34.9 | 34.9 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | False |
| 2503 | 1408 | 1408.0 | 43.7 | 43.7 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | False |
| 2504 | 1407 | 1407.0 | 31.8 | 31.8 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | False |
| 2505 | 1407 | 1407.0 | 25.2 | 25.2 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | False |
| 2506 | 2813 | 1406.5 | 110.4 | 55.2 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 2507 | 1406 | 1406.0 | 28.8 | 28.8 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2508 | 1406 | 1406.0 | 32.6 | 32.6 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | False |
| 2509 | 1406 | 1406.0 | 25.9 | 25.9 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | False |
| 2510 | 1406 | 1406.0 | 37.6 | 37.6 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | False |
| 2511 | 1406 | 1406.0 | 38.5 | 38.5 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2512 | 1406 | 1406.0 | 39.3 | 39.3 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | False |
| 2513 | 1406 | 1406.0 | 40.1 | 40.1 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | False |
| 2514 | 1405 | 1405.0 | 32.6 | 32.6 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2515 | 1405 | 1405.0 | 43.4 | 43.4 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2516 | 1405 | 1405.0 | 54.2 | 54.2 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | False |
| 2517 | 1403 | 1403.0 | 43.0 | 43.0 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | False |
| 2518 | 1403 | 1403.0 | 28.9 | 28.9 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | False |
| 2519 | 2805 | 1402.5 | 83.7 | 41.9 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2520 | 7011 | 1402.2 | 250.6 | 50.1 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2521 | 2804 | 1402.0 | 69.2 | 34.6 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | False |
| 2522 | 5607 | 1401.8 | 192.2 | 48.0 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2523 | 2802 | 1401.0 | 61.8 | 30.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2524 | 1401 | 1401.0 | 54.3 | 54.3 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A de Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 2525 | 1400 | 1400.0 | 47.5 | 47.5 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2526 | 1400 | 1400.0 | 31.2 | 31.2 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | False |
| 2527 | 1400 | 1400.0 | 49.7 | 49.7 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2528 | 1400 | 1400.0 | 49.2 | 49.2 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | False |
| 2529 | 1399 | 1399.0 | 28.1 | 28.1 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | False |
| 2530 | 1399 | 1399.0 | 31.1 | 31.1 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | False |
| 2531 | 2798 | 1399.0 | 68.8 | 34.4 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | False |
| 2532 | 1399 | 1399.0 | 41.2 | 41.2 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | False |
| 2533 | 2797 | 1398.5 | 72.3 | 36.1 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2534 | 2796 | 1398.0 | 63.6 | 31.8 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | False |
| 2535 | 2796 | 1398.0 | 117.5 | 58.8 | AMPK: guardian of metabolism and mitochondrial homeostasis. | Sébastien Herzig, Reuben J Shaw | Nat Rev Mol Cell Biol | 2018 | 28974774 | False |
| 2536 | 2795 | 1397.5 | 98.3 | 49.1 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | False |
| 2537 | 2793 | 1396.5 | 128.0 | 64.0 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2538 | 2793 | 1396.5 | 95.0 | 47.5 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | False |
| 2539 | 2793 | 1396.5 | 62.4 | 31.2 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2540 | 1396 | 1396.0 | 34.2 | 34.2 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | False |
| 2541 | 1396 | 1396.0 | 46.5 | 46.5 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | False |
| 2542 | 2791 | 1395.5 | 60.7 | 30.4 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2543 | 2791 | 1395.5 | 81.6 | 40.8 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P DOLE, H MEINERTZ | J Biol Chem | 1960 | 13817286 | Yes |
| 2544 | 4186 | 1395.3 | 95.9 | 32.0 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2545 | 1395 | 1395.0 | 40.9 | 40.9 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | False |
| 2546 | 2790 | 1395.0 | 170.2 | 85.1 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2547 | 2790 | 1395.0 | 101.1 | 50.5 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 2548 | 6973 | 1394.6 | 129.9 | 26.0 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2549 | 2789 | 1394.5 | 104.8 | 52.4 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2550 | 8367 | 1394.5 | 289.5 | 48.2 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 2551 | 1394 | 1394.0 | 42.2 | 42.2 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2552 | 1393 | 1393.0 | 21.1 | 21.1 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2553 | 1393 | 1393.0 | 30.7 | 30.7 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | False |
| 2554 | 2786 | 1393.0 | 62.0 | 31.0 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | False |
| 2555 | 5571 | 1392.8 | 147.2 | 36.8 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2556 | 2785 | 1392.5 | 101.0 | 50.5 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | False |
| 2557 | 2785 | 1392.5 | 61.5 | 30.8 | Immunoassay of endogenous plasma insulin in man. | R S YALOW, S A BERSON | J Clin Invest | 1960 | 13846364 | Yes |
| 2558 | 2785 | 1392.5 | 54.1 | 27.1 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | False |
| 2559 | 4177 | 1392.3 | 79.3 | 26.4 | Exosomes: composition, biogenesis and function. | Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | False |
| 2560 | 4177 | 1392.3 | 83.6 | 27.9 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | False |
| 2561 | 2784 | 1392.0 | 86.2 | 43.1 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2562 | 1392 | 1392.0 | 22.2 | 22.2 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | False |
| 2563 | 2784 | 1392.0 | 73.2 | 36.6 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 2564 | 2783 | 1391.5 | 105.7 | 52.9 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2565 | 8348 | 1391.3 | 219.1 | 36.5 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2566 | 1391 | 1391.0 | 32.2 | 32.2 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | False |
| 2567 | 5561 | 1390.2 | 141.0 | 35.2 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2568 | 2780 | 1390.0 | 66.2 | 33.1 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2569 | 2780 | 1390.0 | 59.8 | 29.9 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2570 | 1388 | 1388.0 | 29.5 | 29.5 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | False |
| 2571 | 4163 | 1387.7 | 93.4 | 31.1 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | False |
| 2572 | 1387 | 1387.0 | 60.3 | 60.3 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2573 | 1387 | 1387.0 | 25.0 | 25.0 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | False |
| 2574 | 2774 | 1387.0 | 86.9 | 43.5 | CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. | Jing Huang, Alexander D MacKerell | J Comput Chem | 2013 | 23832629 | Yes |
| 2575 | 4159 | 1386.3 | 105.2 | 35.1 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2576 | 1386 | 1386.0 | 25.5 | 25.5 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | False |
| 2577 | 2772 | 1386.0 | 67.6 | 33.8 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | False |
| 2578 | 2770 | 1385.0 | 71.1 | 35.5 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2579 | 1385 | 1385.0 | 40.7 | 40.7 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | False |
| 2580 | 1385 | 1385.0 | 26.2 | 26.2 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | False |
| 2581 | 1384 | 1384.0 | 38.4 | 38.4 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2582 | 6920 | 1384.0 | 185.7 | 37.1 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2583 | 1384 | 1384.0 | 34.9 | 34.9 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | False |
| 2584 | 1384 | 1384.0 | 48.1 | 48.1 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | False |
| 2585 | 2766 | 1383.0 | 55.4 | 27.7 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | False |
| 2586 | 1383 | 1383.0 | 24.1 | 24.1 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | False |
| 2587 | 1383 | 1383.0 | 29.5 | 29.5 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | False |
| 2588 | 4148 | 1382.7 | 90.9 | 30.3 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | False |
| 2589 | 2765 | 1382.5 | 87.9 | 44.0 | MissForest--non-parametric missing value imputation for mixed-type data. | Daniel J Stekhoven, Peter Bühlmann | Bioinformatics | 2012 | 22039212 | Yes |
| 2590 | 1382 | 1382.0 | 24.0 | 24.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2591 | 2764 | 1382.0 | 77.0 | 38.5 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2592 | 1382 | 1382.0 | 31.6 | 31.6 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2593 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C SCHNEIDER | J Biol Chem | 1948 | 18886166 | Yes |
| 2594 | 1382 | 1382.0 | 27.8 | 27.8 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | False |
| 2595 | 2763 | 1381.5 | 61.2 | 30.6 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2596 | 2763 | 1381.5 | 70.3 | 35.1 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2597 | 9667 | 1381.0 | 282.7 | 40.4 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2598 | 5524 | 1381.0 | 118.9 | 29.7 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2599 | 1381 | 1381.0 | 34.2 | 34.2 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | False |
| 2600 | 1381 | 1381.0 | 32.3 | 32.3 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | False |
| 2601 | 1381 | 1381.0 | 41.0 | 41.0 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | False |
| 2602 | 1381 | 1381.0 | 80.6 | 80.6 | Head and Neck Cancer. | Laura Q M Chow | N Engl J Med | 2020 | 31893516 | False |
| 2603 | 1380 | 1380.0 | 31.0 | 31.0 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | False |
| 2604 | 1380 | 1380.0 | 27.5 | 27.5 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | False |
| 2605 | 1380 | 1380.0 | 28.4 | 28.4 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | False |
| 2606 | 2760 | 1380.0 | 70.6 | 35.3 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | False |
| 2607 | 1379 | 1379.0 | 72.3 | 72.3 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | False |
| 2608 | 1378 | 1378.0 | 36.1 | 36.1 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | False |
| 2609 | 1378 | 1378.0 | 35.0 | 35.0 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | False |
| 2610 | 13776 | 1377.6 | 510.2 | 51.0 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 2611 | 2755 | 1377.5 | 113.4 | 56.7 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 2612 | 1377 | 1377.0 | 43.2 | 43.2 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | False |
| 2613 | 2754 | 1377.0 | 70.3 | 35.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2614 | 2752 | 1376.0 | 96.4 | 48.2 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2615 | 2750 | 1375.0 | 54.5 | 27.2 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | False |
| 2616 | 1373 | 1373.0 | 10.9 | 10.9 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2617 | 1373 | 1373.0 | 34.6 | 34.6 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | False |
| 2618 | 4118 | 1372.7 | 118.3 | 39.4 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | False |
| 2619 | 2744 | 1372.0 | 82.8 | 41.4 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | False |
| 2620 | 2744 | 1372.0 | 0.0 | 0.0 | Construct validity in psychological tests. | L J CRONBACH, P E MEEHL | Psychol Bull | 1955 | 13245896 | Yes |
| 2621 | 1372 | 1372.0 | 31.1 | 31.1 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | False |
| 2622 | 2743 | 1371.5 | 54.6 | 27.3 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2623 | 1371 | 1371.0 | 23.6 | 23.6 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | False |
| 2624 | 1371 | 1371.0 | 36.7 | 36.7 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | False |
| 2625 | 1371 | 1371.0 | 40.4 | 40.4 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | False |
| 2626 | 1371 | 1371.0 | 64.0 | 64.0 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 2627 | 1371 | 1371.0 | 64.8 | 64.8 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 2628 | 8224 | 1370.7 | 203.1 | 33.9 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2629 | 2740 | 1370.0 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B CHANCE, G R WILLIAMS | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2630 | 1370 | 1370.0 | 11.6 | 11.6 | Immunological function of the thymus. | J F MILLER | Lancet | 1961 | 14474038 | Yes |
| 2631 | 1370 | 1370.0 | 39.1 | 39.1 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2632 | 1370 | 1370.0 | 32.3 | 32.3 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | False |
| 2633 | 1370 | 1370.0 | 51.6 | 51.6 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | False |
| 2634 | 1370 | 1370.0 | 44.1 | 44.1 | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. | Tristan Ian Croll | Acta Crystallogr D Struct Biol | 2018 | 29872003 | Yes |
| 2635 | 4109 | 1369.7 | 120.0 | 40.0 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2636 | 5477 | 1369.2 | 125.6 | 31.4 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2637 | 1369 | 1369.0 | 14.8 | 14.8 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | False |
| 2638 | 1369 | 1369.0 | 43.6 | 43.6 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | False |
| 2639 | 4105 | 1368.3 | 145.9 | 48.6 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2640 | 1368 | 1368.0 | 47.1 | 47.1 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2641 | 1368 | 1368.0 | 32.7 | 32.7 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2642 | 1368 | 1368.0 | 37.7 | 37.7 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | False |
| 2643 | 1368 | 1368.0 | 35.3 | 35.3 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | False |
| 2644 | 1368 | 1368.0 | 36.5 | 36.5 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | False |
| 2645 | 1368 | 1368.0 | 42.9 | 42.9 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | False |
| 2646 | 2735 | 1367.5 | 53.8 | 26.9 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2647 | 1367 | 1367.0 | 28.2 | 28.2 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2648 | 1367 | 1367.0 | 43.7 | 43.7 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 2649 | 1367 | 1367.0 | 22.9 | 22.9 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | False |
| 2650 | 2732 | 1366.0 | 56.0 | 28.0 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2651 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O SMITHIES | Biochem J | 1959 | 13638269 | Yes |
| 2652 | 1365 | 1365.0 | 32.3 | 32.3 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2653 | 2730 | 1365.0 | 163.7 | 81.8 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2654 | 1365 | 1365.0 | 0.0 | 0.0 | On the psychophysical law. | S S STEVENS | Psychol Rev | 1957 | 13441853 | Yes |
| 2655 | 1364 | 1364.0 | 46.7 | 46.7 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | False |
| 2656 | 1364 | 1364.0 | 46.1 | 46.1 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | False |
| 2657 | 1364 | 1364.0 | 27.0 | 27.0 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | False |
| 2658 | 1364 | 1364.0 | 38.9 | 38.9 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | False |
| 2659 | 2728 | 1364.0 | 97.0 | 48.5 | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. | Christoph Hafemeister, Rahul Satija | Genome Biol | 2019 | 31870423 | Yes |
| 2660 | 1363 | 1363.0 | 41.8 | 41.8 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2661 | 1362 | 1362.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B CLOWARD | J Neurosurg | 1958 | 13599052 | Yes |
| 2662 | 1362 | 1362.0 | 30.9 | 30.9 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | False |
| 2663 | 1362 | 1362.0 | 27.3 | 27.3 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | False |
| 2664 | 1362 | 1362.0 | 49.0 | 49.0 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | False |
| 2665 | 6809 | 1361.8 | 346.2 | 69.2 | Standards for reporting qualitative research: a synthesis of recommendations. | Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook | Acad Med | 2014 | 24979285 | Yes |
| 2666 | 1361 | 1361.0 | 33.7 | 33.7 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | False |
| 2667 | 1361 | 1361.0 | 35.4 | 35.4 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | False |
| 2668 | 1361 | 1361.0 | 28.7 | 28.7 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 2669 | 1360 | 1360.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M REITAN | J Consult Psychol | 1955 | 13263471 | Yes |
| 2670 | 2720 | 1360.0 | 67.2 | 33.6 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | False |
| 2671 | 1359 | 1359.0 | 30.3 | 30.3 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2672 | 1358 | 1358.0 | 41.9 | 41.9 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | False |
| 2673 | 1358 | 1358.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B CAULFIELD | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2674 | 2715 | 1357.5 | 50.5 | 25.2 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 2675 | 1357 | 1357.0 | 41.1 | 41.1 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | False |
| 2676 | 1357 | 1357.0 | 33.0 | 33.0 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | False |
| 2677 | 5427 | 1356.8 | 105.4 | 26.4 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2678 | 2712 | 1356.0 | 73.8 | 36.9 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2679 | 2712 | 1356.0 | 54.0 | 27.0 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 2680 | 1356 | 1356.0 | 28.6 | 28.6 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | False |
| 2681 | 1356 | 1356.0 | 31.7 | 31.7 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | False |
| 2682 | 2712 | 1356.0 | 56.8 | 28.4 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | False |
| 2683 | 1355 | 1355.0 | 58.2 | 58.2 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2684 | 1355 | 1355.0 | 23.1 | 23.1 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2685 | 1355 | 1355.0 | 42.1 | 42.1 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | False |
| 2686 | 1355 | 1355.0 | 44.9 | 44.9 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | False |
| 2687 | 5418 | 1354.5 | 124.3 | 31.1 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2688 | 2709 | 1354.5 | 47.0 | 23.5 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | False |
| 2689 | 5418 | 1354.5 | 260.5 | 65.1 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 2690 | 1354 | 1354.0 | 28.5 | 28.5 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2691 | 1354 | 1354.0 | 63.5 | 63.5 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | False |
| 2692 | 1354 | 1354.0 | 35.1 | 35.1 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | False |
| 2693 | 2707 | 1353.5 | 61.9 | 30.9 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | False |
| 2694 | 5413 | 1353.2 | 116.2 | 29.1 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2695 | 1353 | 1353.0 | 48.6 | 48.6 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2696 | 4058 | 1352.7 | 49.7 | 16.6 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D SABATINI, K BENSCH, R J BARRNETT | J Cell Biol | 1963 | 13975866 | Yes |
| 2697 | 2704 | 1352.0 | 61.2 | 30.6 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | False |
| 2698 | 1352 | 1352.0 | 43.1 | 43.1 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | False |
| 2699 | 2704 | 1352.0 | 66.1 | 33.0 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | False |
| 2700 | 1352 | 1352.0 | 65.0 | 65.0 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | False |
| 2701 | 1351 | 1351.0 | 48.2 | 48.2 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | False |
| 2702 | 1351 | 1351.0 | 37.8 | 37.8 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | False |
| 2703 | 1351 | 1351.0 | 25.7 | 25.7 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | False |
| 2704 | 1351 | 1351.0 | 29.6 | 29.6 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2705 | 1351 | 1351.0 | 32.7 | 32.7 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2706 | 2701 | 1350.5 | 120.5 | 60.2 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2707 | 4051 | 1350.3 | 91.1 | 30.4 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | False |
| 2708 | 1350 | 1350.0 | 34.1 | 34.1 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | False |
| 2709 | 2699 | 1349.5 | 39.4 | 19.7 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2710 | 8096 | 1349.3 | 225.5 | 37.6 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | False |
| 2711 | 1349 | 1349.0 | 35.3 | 35.3 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | False |
| 2712 | 1349 | 1349.0 | 29.7 | 29.7 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2713 | 4045 | 1348.3 | 125.7 | 41.9 | Mendelian randomization analysis with multiple genetic variants using summarized data. | Stephen Burgess, Adam Butterworth, Simon G Thompson | Genet Epidemiol | 2013 | 24114802 | Yes |
| 2714 | 2696 | 1348.0 | 68.8 | 34.4 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | False |
| 2715 | 1348 | 1348.0 | 35.5 | 35.5 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | False |
| 2716 | 2696 | 1348.0 | 58.9 | 29.4 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2717 | 4042 | 1347.3 | 83.5 | 27.8 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2718 | 2694 | 1347.0 | 62.1 | 31.1 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2719 | 2694 | 1347.0 | 68.5 | 34.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | False |
| 2720 | 1347 | 1347.0 | 23.0 | 23.0 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | False |
| 2721 | 1347 | 1347.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J WADDELL | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2722 | 1347 | 1347.0 | 35.7 | 35.7 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2723 | 2693 | 1346.5 | 99.5 | 49.8 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | False |
| 2724 | 2692 | 1346.0 | 119.7 | 59.9 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | False |
| 2725 | 2691 | 1345.5 | 57.5 | 28.8 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2726 | 4036 | 1345.3 | 127.5 | 42.5 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2727 | 1345 | 1345.0 | 17.3 | 17.3 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | False |
| 2728 | 1345 | 1345.0 | 23.3 | 23.3 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | False |
| 2729 | 2688 | 1344.0 | 88.3 | 44.1 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2730 | 1344 | 1344.0 | 49.1 | 49.1 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | False |
| 2731 | 2688 | 1344.0 | 76.1 | 38.0 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M van der Bliek | Science | 2012 | 22936770 | False |
| 2732 | 4031 | 1343.7 | 257.4 | 85.8 | Correlation Coefficients: Appropriate Use and Interpretation. | Patrick Schober, Christa Boer, Lothar A Schwarte | Anesth Analg | 2018 | 29481436 | False |
| 2733 | 2687 | 1343.5 | 68.7 | 34.4 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2734 | 2685 | 1342.5 | 134.2 | 67.1 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2735 | 2685 | 1342.5 | 55.7 | 27.9 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | False |
| 2736 | 1342 | 1342.0 | 35.5 | 35.5 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | False |
| 2737 | 1342 | 1342.0 | 33.4 | 33.4 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | False |
| 2738 | 1342 | 1342.0 | 24.3 | 24.3 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | False |
| 2739 | 4022 | 1340.7 | 99.4 | 33.1 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2740 | 5362 | 1340.5 | 169.1 | 42.3 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2741 | 1340 | 1340.0 | 46.7 | 46.7 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2742 | 2680 | 1340.0 | 52.1 | 26.1 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | False |
| 2743 | 1340 | 1340.0 | 44.6 | 44.6 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 2744 | 2678 | 1339.0 | 71.5 | 35.8 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 2745 | 2678 | 1339.0 | 83.6 | 41.8 | Liquid phase condensation in cell physiology and disease. | Yongdae Shin, Clifford P Brangwynne | Science | 2017 | 28935776 | False |
| 2746 | 1338 | 1338.0 | 44.1 | 44.1 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | False |
| 2747 | 1338 | 1338.0 | 65.8 | 65.8 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2748 | 5352 | 1338.0 | 119.3 | 29.8 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | False |
| 2749 | 2674 | 1337.0 | 220.1 | 110.0 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2750 | 1337 | 1337.0 | 35.0 | 35.0 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | False |
| 2751 | 4011 | 1337.0 | 123.7 | 41.2 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2752 | 1337 | 1337.0 | 25.2 | 25.2 | A modified procedure for lead staining of thin sections. | G MILLONIG | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2753 | 1337 | 1337.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W TUKEY | Biometrics | 1949 | 18151955 | Yes |
| 2754 | 5346 | 1336.5 | 298.4 | 74.6 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2755 | 1336 | 1336.0 | 46.1 | 46.1 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2756 | 1336 | 1336.0 | 55.2 | 55.2 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2757 | 2671 | 1335.5 | 63.8 | 31.9 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | False |
| 2758 | 2670 | 1335.0 | 79.5 | 39.8 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2759 | 1335 | 1335.0 | 35.8 | 35.8 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | False |
| 2760 | 1335 | 1335.0 | 62.8 | 62.8 | Cellular resistance to infection. | G B MACKANESS | J Exp Med | 1962 | 14467923 | Yes |
| 2761 | 1335 | 1335.0 | 35.3 | 35.3 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 2762 | 2669 | 1334.5 | 104.8 | 52.4 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | False |
| 2763 | 1334 | 1334.0 | 24.6 | 24.6 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | False |
| 2764 | 2668 | 1334.0 | 44.8 | 22.4 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | False |
| 2765 | 1333 | 1333.0 | 45.1 | 45.1 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | False |
| 2766 | 1333 | 1333.0 | 39.5 | 39.5 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | False |
| 2767 | 2664 | 1332.0 | 49.4 | 24.7 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2768 | 1332 | 1332.0 | 50.7 | 50.7 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | False |
| 2769 | 2664 | 1332.0 | 72.6 | 36.3 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | False |
| 2770 | 3994 | 1331.3 | 83.5 | 27.8 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 2771 | 1331 | 1331.0 | 32.6 | 32.6 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2772 | 1331 | 1331.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J BERKSON | Biometrics | 1946 | 21001024 | Yes |
| 2773 | 2661 | 1330.5 | 99.9 | 50.0 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2774 | 2661 | 1330.5 | 138.5 | 69.2 | Depression. | Gin S Malhi, J John Mann | Lancet | 2018 | 30396512 | False |
| 2775 | 5321 | 1330.2 | 159.0 | 39.8 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | False |
| 2776 | 5320 | 1330.0 | 130.4 | 32.6 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 2777 | 1330 | 1330.0 | 29.7 | 29.7 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | False |
| 2778 | 1330 | 1330.0 | 32.1 | 32.1 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2779 | 2660 | 1330.0 | 78.8 | 39.4 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | False |
| 2780 | 2660 | 1330.0 | 97.4 | 48.7 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | False |
| 2781 | 2659 | 1329.5 | 71.3 | 35.6 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | False |
| 2782 | 1329 | 1329.0 | 24.7 | 24.7 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2783 | 1329 | 1329.0 | 33.4 | 33.4 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | False |
| 2784 | 1329 | 1329.0 | 34.4 | 34.4 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2785 | 2657 | 1328.5 | 62.1 | 31.1 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2786 | 2656 | 1328.0 | 78.2 | 39.1 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | False |
| 2787 | 1328 | 1328.0 | 29.8 | 29.8 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | False |
| 2788 | 1328 | 1328.0 | 34.6 | 34.6 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | False |
| 2789 | 5309 | 1327.2 | 122.4 | 30.6 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2790 | 1327 | 1327.0 | 51.3 | 51.3 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2791 | 1327 | 1327.0 | 46.1 | 46.1 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | False |
| 2792 | 1327 | 1327.0 | 42.7 | 42.7 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | False |
| 2793 | 2653 | 1326.5 | 60.0 | 30.0 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | False |
| 2794 | 3979 | 1326.3 | 193.6 | 64.5 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2795 | 10609 | 1326.1 | 259.0 | 32.4 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2796 | 1326 | 1326.0 | 27.7 | 27.7 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2797 | 1326 | 1326.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2798 | 2652 | 1326.0 | 58.4 | 29.2 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | False |
| 2799 | 3978 | 1326.0 | 97.9 | 32.6 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 2800 | 1325 | 1325.0 | 27.2 | 27.2 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | False |
| 2801 | 2649 | 1324.5 | 64.1 | 32.0 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | False |
| 2802 | 2649 | 1324.5 | 52.3 | 26.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | False |
| 2803 | 3972 | 1324.0 | 96.3 | 32.1 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | False |
| 2804 | 3972 | 1324.0 | 94.2 | 31.4 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2805 | 1324 | 1324.0 | 27.0 | 27.0 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | False |
| 2806 | 2647 | 1323.5 | 87.3 | 43.6 | Severe sepsis and septic shock. | Derek C Angus, Tom van der Poll | N Engl J Med | 2013 | 23984731 | False |
| 2807 | 11909 | 1323.2 | 290.0 | 32.2 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2808 | 2646 | 1323.0 | 65.2 | 32.6 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | False |
| 2809 | 1323 | 1323.0 | 32.2 | 32.2 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2810 | 1323 | 1323.0 | 65.6 | 65.6 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. | Nicholas A Meanwell | J Med Chem | 2018 | 29400967 | False |
| 2811 | 1322 | 1322.0 | 22.6 | 22.6 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | False |
| 2812 | 1322 | 1322.0 | 35.4 | 35.4 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | False |
| 2813 | 3966 | 1322.0 | 91.8 | 30.6 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 2814 | 3965 | 1321.7 | 119.9 | 40.0 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2815 | 2643 | 1321.5 | 88.5 | 44.2 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | False |
| 2816 | 2642 | 1321.0 | 65.0 | 32.5 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | False |
| 2817 | 1321 | 1321.0 | 37.3 | 37.3 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2818 | 1321 | 1321.0 | 59.4 | 59.4 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 2819 | 5283 | 1320.8 | 133.1 | 33.3 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2820 | 2641 | 1320.5 | 90.6 | 45.3 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2821 | 5278 | 1319.5 | 144.2 | 36.0 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 2822 | 6597 | 1319.4 | 205.4 | 41.1 | CD-HIT: accelerated for clustering the next-generation sequencing data. | Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li | Bioinformatics | 2012 | 23060610 | Yes |
| 2823 | 1319 | 1319.0 | 54.7 | 54.7 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2824 | 6595 | 1319.0 | 161.9 | 32.4 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 2825 | 1319 | 1319.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A BERG | J Gen Psychol | 1948 | 18889466 | Yes |
| 2826 | 2637 | 1318.5 | 73.3 | 36.6 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 2827 | 5273 | 1318.2 | 144.9 | 36.2 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 2828 | 2636 | 1318.0 | 40.5 | 20.2 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 2829 | 1318 | 1318.0 | 36.0 | 36.0 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | False |
| 2830 | 1318 | 1318.0 | 30.1 | 30.1 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | False |
| 2831 | 2635 | 1317.5 | 45.9 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2832 | 2635 | 1317.5 | 57.0 | 28.5 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | False |
| 2833 | 2635 | 1317.5 | 74.3 | 37.1 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | False |
| 2834 | 2635 | 1317.5 | 77.1 | 38.5 | Opportunities and challenges for a sustainable energy future. | Steven Chu, Arun Majumdar | Nature | 2012 | 22895334 | False |
| 2835 | 1317 | 1317.0 | 52.2 | 52.2 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | Yes |
| 2836 | 5265 | 1316.2 | 230.3 | 57.6 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Göker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 2837 | 1316 | 1316.0 | 56.4 | 56.4 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2838 | 1316 | 1316.0 | 33.9 | 33.9 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | False |
| 2839 | 1316 | 1316.0 | 21.9 | 21.9 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | False |
| 2840 | 2632 | 1316.0 | 55.0 | 27.5 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | False |
| 2841 | 2631 | 1315.5 | 84.3 | 42.1 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschöpe | J Am Coll Cardiol | 2013 | 23684677 | False |
| 2842 | 1315 | 1315.0 | 37.2 | 37.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | False |
| 2843 | 2630 | 1315.0 | 50.1 | 25.1 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | False |
| 2844 | 1315 | 1315.0 | 28.7 | 28.7 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | False |
| 2845 | 1315 | 1315.0 | 29.9 | 29.9 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | False |
| 2846 | 2629 | 1314.5 | 67.1 | 33.5 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | False |
| 2847 | 1314 | 1314.0 | 35.5 | 35.5 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 2848 | 1314 | 1314.0 | 31.1 | 31.1 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | False |
| 2849 | 1314 | 1314.0 | 34.6 | 34.6 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | False |
| 2850 | 1314 | 1314.0 | 35.6 | 35.6 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | False |
| 2851 | 1313 | 1313.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J BATEMAN | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2852 | 2625 | 1312.5 | 83.1 | 41.5 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | False |
| 2853 | 1312 | 1312.0 | 32.1 | 32.1 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | False |
| 2854 | 1312 | 1312.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F SCHOLANDER | J Biol Chem | 1947 | 20281644 | Yes |
| 2855 | 1312 | 1312.0 | 45.1 | 45.1 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 2856 | 7870 | 1311.7 | 279.2 | 46.5 | Second-generation PLINK: rising to the challenge of larger and richer datasets. | Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee | Gigascience | 2015 | 25722852 | Yes |
| 2857 | 2623 | 1311.5 | 43.4 | 21.7 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 2858 | 2622 | 1311.0 | 49.6 | 24.8 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 2859 | 2622 | 1311.0 | 73.0 | 36.5 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | False |
| 2860 | 1311 | 1311.0 | 62.3 | 62.3 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 2861 | 2621 | 1310.5 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A EDMONDSON, P E STEINER | Cancer | 1954 | 13160935 | Yes |
| 2862 | 7863 | 1310.5 | 232.5 | 38.8 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 2863 | 1310 | 1310.0 | 34.4 | 34.4 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | False |
| 2864 | 1309 | 1309.0 | 39.4 | 39.4 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | False |
| 2865 | 1309 | 1309.0 | 61.4 | 61.4 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 2866 | 1309 | 1309.0 | 27.5 | 27.5 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | False |
| 2867 | 3926 | 1308.7 | 114.9 | 38.3 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | False |
| 2868 | 2617 | 1308.5 | 59.2 | 29.6 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2869 | 1308 | 1308.0 | 30.8 | 30.8 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | False |
| 2870 | 2616 | 1308.0 | 61.4 | 30.7 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 2871 | 2615 | 1307.5 | 55.2 | 27.6 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | False |
| 2872 | 2615 | 1307.5 | 46.6 | 23.3 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | False |
| 2873 | 3921 | 1307.0 | 162.5 | 54.2 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 2874 | 2614 | 1307.0 | 24.2 | 12.1 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 2875 | 5227 | 1306.8 | 135.2 | 33.8 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 2876 | 3918 | 1306.0 | 173.1 | 57.7 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2877 | 1306 | 1306.0 | 23.1 | 23.1 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | False |
| 2878 | 1306 | 1306.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S FARR | J Infect Dis | 1958 | 13611294 | Yes |
| 2879 | 1306 | 1306.0 | 26.1 | 26.1 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | False |
| 2880 | 1305 | 1305.0 | 46.6 | 46.6 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | False |
| 2881 | 1305 | 1305.0 | 31.3 | 31.3 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2882 | 1305 | 1305.0 | 28.8 | 28.8 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 2883 | 3915 | 1305.0 | 91.3 | 30.4 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | False |
| 2884 | 2610 | 1305.0 | 59.4 | 29.7 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | False |
| 2885 | 2610 | 1305.0 | 93.1 | 46.5 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Théry | Cell | 2016 | 26967288 | False |
| 2886 | 2608 | 1304.0 | 67.6 | 33.8 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 2887 | 1304 | 1304.0 | 25.2 | 25.2 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2888 | 2607 | 1303.5 | 63.2 | 31.6 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | False |
| 2889 | 2607 | 1303.5 | 65.4 | 32.7 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2890 | 1303 | 1303.0 | 52.0 | 52.0 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2891 | 1303 | 1303.0 | 34.5 | 34.5 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2892 | 2606 | 1303.0 | 51.3 | 25.6 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | False |
| 2893 | 1303 | 1303.0 | 29.8 | 29.8 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | False |
| 2894 | 3908 | 1302.7 | 121.0 | 40.3 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | False |
| 2895 | 2605 | 1302.5 | 106.2 | 53.1 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2896 | 3907 | 1302.3 | 105.0 | 35.0 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2897 | 1302 | 1302.0 | 43.2 | 43.2 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | False |
| 2898 | 1302 | 1302.0 | 43.5 | 43.5 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamás Rőszer | Mediators Inflamm | 2015 | 26089604 | False |
| 2899 | 3904 | 1301.3 | 104.3 | 34.8 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | False |
| 2900 | 5204 | 1301.0 | 106.9 | 26.7 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | False |
| 2901 | 2602 | 1301.0 | 57.0 | 28.5 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P van den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 2902 | 1301 | 1301.0 | 42.9 | 42.9 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | False |
| 2903 | 2601 | 1300.5 | 83.6 | 41.8 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | False |
| 2904 | 2600 | 1300.0 | 49.9 | 24.9 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 2905 | 2599 | 1299.5 | 54.1 | 27.1 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | False |
| 2906 | 2598 | 1299.0 | 77.3 | 38.6 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 2907 | 2598 | 1299.0 | 58.9 | 29.4 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 2908 | 1298 | 1298.0 | 32.6 | 32.6 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 2909 | 1298 | 1298.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C BRUTON | Pediatrics | 1952 | 14929630 | Yes |
| 2910 | 2596 | 1298.0 | 56.5 | 28.2 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | False |
| 2911 | 2596 | 1298.0 | 65.6 | 32.8 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | False |
| 2912 | 2595 | 1297.5 | 76.8 | 38.4 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | False |
| 2913 | 2594 | 1297.0 | 70.9 | 35.5 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2914 | 1297 | 1297.0 | 30.9 | 30.9 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | False |
| 2915 | 1297 | 1297.0 | 32.3 | 32.3 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | False |
| 2916 | 1297 | 1297.0 | 32.8 | 32.8 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 2917 | 2594 | 1297.0 | 67.3 | 33.6 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | False |
| 2918 | 1296 | 1296.0 | 26.6 | 26.6 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | False |
| 2919 | 1296 | 1296.0 | 57.0 | 57.0 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | False |
| 2920 | 1295 | 1295.0 | 46.2 | 46.2 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 2921 | 2589 | 1294.5 | 44.8 | 22.4 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | False |
| 2922 | 1294 | 1294.0 | 28.8 | 28.8 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | False |
| 2923 | 1294 | 1294.0 | 84.3 | 84.3 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 2924 | 2588 | 1294.0 | 52.6 | 26.3 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | False |
| 2925 | 1294 | 1294.0 | 26.1 | 26.1 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | False |
| 2926 | 1293 | 1293.0 | 42.6 | 42.6 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 2927 | 1293 | 1293.0 | 32.3 | 32.3 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | False |
| 2928 | 7758 | 1293.0 | 221.5 | 36.9 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 2929 | 1292 | 1292.0 | 34.5 | 34.5 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | False |
| 2930 | 1292 | 1292.0 | 42.2 | 42.2 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 2931 | 1292 | 1292.0 | 26.8 | 26.8 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | False |
| 2932 | 2584 | 1292.0 | 78.7 | 39.4 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | False |
| 2933 | 1291 | 1291.0 | 66.8 | 66.8 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2934 | 1291 | 1291.0 | 45.5 | 45.5 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2935 | 1291 | 1291.0 | 32.1 | 32.1 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 2936 | 1291 | 1291.0 | 33.6 | 33.6 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | False |
| 2937 | 1291 | 1291.0 | 43.4 | 43.4 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | False |
| 2938 | 1291 | 1291.0 | 30.6 | 30.6 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 2939 | 1291 | 1291.0 | 30.8 | 30.8 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | False |
| 2940 | 2580 | 1290.0 | 66.9 | 33.5 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 2941 | 1290 | 1290.0 | 44.1 | 44.1 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | False |
| 2942 | 1290 | 1290.0 | 53.1 | 53.1 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 2943 | 3869 | 1289.7 | 90.4 | 30.1 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 2944 | 2579 | 1289.5 | 68.7 | 34.4 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 2945 | 1289 | 1289.0 | 30.9 | 30.9 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 2946 | 6444 | 1288.8 | 178.8 | 35.8 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 2947 | 3865 | 1288.3 | 94.2 | 31.4 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | False |
| 2948 | 1288 | 1288.0 | 36.7 | 36.7 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 2949 | 2576 | 1288.0 | 47.8 | 23.9 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 2950 | 1288 | 1288.0 | 30.1 | 30.1 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | False |
| 2951 | 2576 | 1288.0 | 44.4 | 22.2 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | False |
| 2952 | 1288 | 1288.0 | 37.9 | 37.9 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | False |
| 2953 | 1288 | 1288.0 | 30.2 | 30.2 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | False |
| 2954 | 2575 | 1287.5 | 89.9 | 45.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | False |
| 2955 | 1287 | 1287.0 | 34.1 | 34.1 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 2956 | 1287 | 1287.0 | 39.6 | 39.6 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | False |
| 2957 | 1287 | 1287.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L MILLER | Science | 1953 | 13056598 | Yes |
| 2958 | 2573 | 1286.5 | 60.7 | 30.4 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 2959 | 1286 | 1286.0 | 38.8 | 38.8 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | False |
| 2960 | 1286 | 1286.0 | 37.1 | 37.1 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | False |
| 2961 | 1286 | 1286.0 | 74.7 | 74.7 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 2962 | 3857 | 1285.7 | 88.7 | 29.6 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | False |
| 2963 | 5142 | 1285.5 | 181.0 | 45.2 | MultiQC: summarize analysis results for multiple tools and samples in a single report. | Philip Ewels, Måns Magnusson, Sverker Lundin, Max Käller | Bioinformatics | 2016 | 27312411 | Yes |
| 2964 | 1285 | 1285.0 | 43.9 | 43.9 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 2965 | 1285 | 1285.0 | 29.8 | 29.8 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | False |
| 2966 | 1285 | 1285.0 | 27.3 | 27.3 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | False |
| 2967 | 6423 | 1284.6 | 311.3 | 62.3 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 2968 | 2569 | 1284.5 | 71.7 | 35.9 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 2969 | 2568 | 1284.0 | 78.1 | 39.0 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 2970 | 3852 | 1284.0 | 130.7 | 43.6 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 2971 | 1284 | 1284.0 | 42.6 | 42.6 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | False |
| 2972 | 14123 | 1283.9 | 388.3 | 35.3 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 2973 | 1283 | 1283.0 | 17.2 | 17.2 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 2974 | 1283 | 1283.0 | 38.8 | 38.8 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | False |
| 2975 | 2566 | 1283.0 | 135.8 | 67.9 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R GUILLARD, J H RYTHER | Can J Microbiol | 1962 | 13902807 | Yes |
| 2976 | 2565 | 1282.5 | 65.4 | 32.7 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 2977 | 1282 | 1282.0 | 32.5 | 32.5 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | False |
| 2978 | 1282 | 1282.0 | 28.6 | 28.6 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | False |
| 2979 | 1282 | 1282.0 | 61.0 | 61.0 | Embracing the unknown: disentangling the complexities of the soil microbiome. | Noah Fierer | Nat Rev Microbiol | 2017 | 28824177 | False |
| 2980 | 2562 | 1281.0 | 49.1 | 24.6 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 2981 | 1281 | 1281.0 | 14.3 | 14.3 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 2982 | 1281 | 1281.0 | 61.4 | 61.4 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | False |
| 2983 | 2562 | 1281.0 | 48.2 | 24.1 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | False |
| 2984 | 1281 | 1281.0 | 28.5 | 28.5 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | False |
| 2985 | 1281 | 1281.0 | 24.3 | 24.3 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | False |
| 2986 | 2561 | 1280.5 | 67.3 | 33.6 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | False |
| 2987 | 3841 | 1280.3 | 96.0 | 32.0 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | False |
| 2988 | 1280 | 1280.0 | 25.4 | 25.4 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | False |
| 2989 | 1280 | 1280.0 | 58.7 | 58.7 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 2990 | 1280 | 1280.0 | 36.1 | 36.1 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | False |
| 2991 | 2558 | 1279.0 | 49.0 | 24.5 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 2992 | 1279 | 1279.0 | 24.8 | 24.8 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | False |
| 2993 | 1279 | 1279.0 | 28.5 | 28.5 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | False |
| 2994 | 2557 | 1278.5 | 66.2 | 33.1 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 2995 | 1278 | 1278.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B VERNEY | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 2996 | 1278 | 1278.0 | 48.3 | 48.3 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 2997 | 1278 | 1278.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M KALCKAR | J Biol Chem | 1947 | 20285041 | Yes |
| 2998 | 2555 | 1277.5 | 94.2 | 47.1 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 2999 | 2555 | 1277.5 | 13.4 | 6.7 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J TODARO, H GREEN | J Cell Biol | 1963 | 13985244 | Yes |
| 3000 | 2555 | 1277.5 | 32.1 | 16.1 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H VANDENDOOL, P D KRATZ | J Chromatogr | 1963 | 14062605 | Yes |
| 3001 | 2555 | 1277.5 | 56.5 | 28.2 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | False |
| 3002 | 2554 | 1277.0 | 98.3 | 49.1 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3003 | 1277 | 1277.0 | 29.2 | 29.2 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | False |
| 3004 | 1277 | 1277.0 | 34.3 | 34.3 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | False |
| 3005 | 1277 | 1277.0 | 26.5 | 26.5 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | False |
| 3006 | 1277 | 1277.0 | 33.4 | 33.4 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3007 | 2552 | 1276.0 | 61.6 | 30.8 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | False |
| 3008 | 1276 | 1276.0 | 24.9 | 24.9 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | False |
| 3009 | 1276 | 1276.0 | 31.6 | 31.6 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 3010 | 1276 | 1276.0 | 37.8 | 37.8 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 3011 | 2551 | 1275.5 | 79.4 | 39.7 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | False |
| 3012 | 5100 | 1275.0 | 144.1 | 36.0 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 3013 | 2550 | 1275.0 | 87.4 | 43.7 | Inflammasomes: mechanism of assembly, regulation and signalling. | Petr Broz, Vishva M Dixit | Nat Rev Immunol | 2016 | 27291964 | False |
| 3014 | 3823 | 1274.3 | 108.3 | 36.1 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 3015 | 1274 | 1274.0 | 46.5 | 46.5 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | False |
| 3016 | 1274 | 1274.0 | 37.8 | 37.8 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3017 | 1274 | 1274.0 | 29.4 | 29.4 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | False |
| 3018 | 1274 | 1274.0 | 44.2 | 44.2 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjöström | J Intern Med | 2013 | 23163728 | False |
| 3019 | 3821 | 1273.7 | 113.0 | 37.7 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | False |
| 3020 | 1273 | 1273.0 | 25.7 | 25.7 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | False |
| 3021 | 1273 | 1273.0 | 70.4 | 70.4 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A ROSE | Bull World Health Organ | 1962 | 13974778 | Yes |
| 3022 | 1273 | 1273.0 | 29.8 | 29.8 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | False |
| 3023 | 2545 | 1272.5 | 50.6 | 25.3 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 3024 | 1272 | 1272.0 | 29.1 | 29.1 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 3025 | 2544 | 1272.0 | 81.7 | 40.9 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3026 | 1272 | 1272.0 | 65.5 | 65.5 | Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. | Dimitrios Tsikas | Anal Biochem | 2017 | 27789233 | False |
| 3027 | 2542 | 1271.0 | 65.1 | 32.5 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | False |
| 3028 | 3813 | 1271.0 | 89.5 | 29.8 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Gonçalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 3029 | 1271 | 1271.0 | 41.2 | 41.2 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | False |
| 3030 | 2541 | 1270.5 | 62.0 | 31.0 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | False |
| 3031 | 2540 | 1270.0 | 56.9 | 28.4 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 3032 | 1270 | 1270.0 | 27.7 | 27.7 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | False |
| 3033 | 1270 | 1270.0 | 26.5 | 26.5 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | False |
| 3034 | 1270 | 1270.0 | 38.1 | 38.1 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | False |
| 3035 | 2539 | 1269.5 | 72.4 | 36.2 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | False |
| 3036 | 12693 | 1269.3 | 309.2 | 30.9 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3037 | 3808 | 1269.3 | 95.2 | 31.7 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | False |
| 3038 | 1269 | 1269.0 | 30.2 | 30.2 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | False |
| 3039 | 2538 | 1269.0 | 74.7 | 37.4 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3040 | 2538 | 1269.0 | 58.5 | 29.2 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoît D'Autréaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | False |
| 3041 | 1268 | 1268.0 | 33.9 | 33.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | False |
| 3042 | 1268 | 1268.0 | 36.0 | 36.0 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | False |
| 3043 | 1268 | 1268.0 | 30.0 | 30.0 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3044 | 3800 | 1266.7 | 92.3 | 30.8 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3045 | 11395 | 1266.1 | 278.7 | 31.0 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3046 | 2531 | 1265.5 | 54.4 | 27.2 | The Polycomb complex PRC2 and its mark in life. | Raphaël Margueron, Danny Reinberg | Nature | 2011 | 21248841 | False |
| 3047 | 2531 | 1265.5 | 109.4 | 54.7 | Activation of apoptosis signalling pathways by reactive oxygen species. | Maureen Redza-Dutordoir, Diana A Averill-Bates | Biochim Biophys Acta | 2016 | 27646922 | False |
| 3048 | 3796 | 1265.3 | 107.4 | 35.8 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | False |
| 3049 | 1265 | 1265.0 | 20.8 | 20.8 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 3050 | 1265 | 1265.0 | 31.4 | 31.4 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | False |
| 3051 | 1265 | 1265.0 | 53.0 | 53.0 | Overview of the IL-1 family in innate inflammation and acquired immunity. | Charles A Dinarello | Immunol Rev | 2018 | 29247995 | False |
| 3052 | 2530 | 1265.0 | 144.9 | 72.5 | Sarcopenia. | Alfonso J Cruz-Jentoft, Avan A Sayer | Lancet | 2019 | 31171417 | False |
| 3053 | 2528 | 1264.0 | 67.0 | 33.5 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 3054 | 1264 | 1264.0 | 31.4 | 31.4 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | False |
| 3055 | 2528 | 1264.0 | 58.8 | 29.4 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | False |
| 3056 | 1264 | 1264.0 | 27.8 | 27.8 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | False |
| 3057 | 2528 | 1264.0 | 50.4 | 25.2 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | False |
| 3058 | 2527 | 1263.5 | 72.7 | 36.4 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | False |
| 3059 | 2527 | 1263.5 | 51.1 | 25.6 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | False |
| 3060 | 2525 | 1262.5 | 69.0 | 34.5 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3061 | 1262 | 1262.0 | 45.7 | 45.7 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | False |
| 3062 | 2524 | 1262.0 | 80.4 | 40.2 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3063 | 1262 | 1262.0 | 34.5 | 34.5 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | False |
| 3064 | 1262 | 1262.0 | 72.8 | 72.8 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D WINTER | Nature | 1962 | 14007593 | Yes |
| 3065 | 2523 | 1261.5 | 75.1 | 37.5 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | False |
| 3066 | 1261 | 1261.0 | 21.5 | 21.5 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 3067 | 1261 | 1261.0 | 26.7 | 26.7 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3068 | 3783 | 1261.0 | 105.3 | 35.1 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | Yes |
| 3069 | 2522 | 1261.0 | 56.8 | 28.4 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | False |
| 3070 | 1261 | 1261.0 | 38.0 | 38.0 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 3071 | 1260 | 1260.0 | 22.5 | 22.5 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 3072 | 1260 | 1260.0 | 38.7 | 38.7 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | False |
| 3073 | 2520 | 1260.0 | 115.8 | 57.9 | An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. | Jesper L R Andersson, Stamatios N Sotiropoulos | Neuroimage | 2016 | 26481672 | Yes |
| 3074 | 2519 | 1259.5 | 64.8 | 32.4 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | False |
| 3075 | 1259 | 1259.0 | 25.7 | 25.7 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | False |
| 3076 | 1259 | 1259.0 | 24.6 | 24.6 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | False |
| 3077 | 1259 | 1259.0 | 25.2 | 25.2 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | False |
| 3078 | 1259 | 1259.0 | 40.5 | 40.5 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3079 | 1259 | 1259.0 | 32.1 | 32.1 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | False |
| 3080 | 2517 | 1258.5 | 57.6 | 28.8 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | False |
| 3081 | 7551 | 1258.5 | 168.0 | 28.0 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3082 | 2517 | 1258.5 | 57.9 | 28.9 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | False |
| 3083 | 1258 | 1258.0 | 27.9 | 27.9 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | False |
| 3084 | 1258 | 1258.0 | 25.6 | 25.6 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 3085 | 1258 | 1258.0 | 36.0 | 36.0 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | False |
| 3086 | 1258 | 1258.0 | 34.5 | 34.5 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | False |
| 3087 | 2516 | 1258.0 | 81.9 | 41.0 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 3088 | 2514 | 1257.0 | 51.8 | 25.9 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3089 | 2514 | 1257.0 | 100.5 | 50.2 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3090 | 2514 | 1257.0 | 64.8 | 32.4 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | False |
| 3091 | 1257 | 1257.0 | 34.8 | 34.8 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | False |
| 3092 | 5025 | 1256.2 | 115.6 | 28.9 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3093 | 2512 | 1256.0 | 76.7 | 38.4 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 3094 | 2512 | 1256.0 | 83.9 | 42.0 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3095 | 1256 | 1256.0 | 22.5 | 22.5 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | False |
| 3096 | 1256 | 1256.0 | 26.5 | 26.5 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | False |
| 3097 | 1256 | 1256.0 | 32.1 | 32.1 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | False |
| 3098 | 1256 | 1256.0 | 33.4 | 33.4 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | False |
| 3099 | 2510 | 1255.0 | 76.9 | 38.5 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3100 | 1255 | 1255.0 | 39.1 | 39.1 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | False |
| 3101 | 2510 | 1255.0 | 53.4 | 26.7 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | False |
| 3102 | 1255 | 1255.0 | 34.0 | 34.0 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | False |
| 3103 | 2509 | 1254.5 | 77.3 | 38.6 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | False |
| 3104 | 2508 | 1254.0 | 91.3 | 45.6 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | False |
| 3105 | 2508 | 1254.0 | 68.5 | 34.2 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | False |
| 3106 | 1254 | 1254.0 | 31.3 | 31.3 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | False |
| 3107 | 1254 | 1254.0 | 38.3 | 38.3 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | False |
| 3108 | 2508 | 1254.0 | 64.5 | 32.2 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3109 | 1254 | 1254.0 | 39.9 | 39.9 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | False |
| 3110 | 3761 | 1253.7 | 85.4 | 28.5 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3111 | 1253 | 1253.0 | 30.7 | 30.7 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | False |
| 3112 | 2506 | 1253.0 | 47.9 | 23.9 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3113 | 1253 | 1253.0 | 42.0 | 42.0 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | False |
| 3114 | 1253 | 1253.0 | 23.9 | 23.9 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3115 | 2505 | 1252.5 | 57.6 | 28.8 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 3116 | 1252 | 1252.0 | 26.9 | 26.9 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | False |
| 3117 | 1252 | 1252.0 | 0.0 | 0.0 | A modification of receptor theory. | R P STEPHENSON | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 3118 | 2504 | 1252.0 | 49.9 | 24.9 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | False |
| 3119 | 5007 | 1251.8 | 131.9 | 33.0 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | False |
| 3120 | 2503 | 1251.5 | 57.0 | 28.5 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3121 | 2503 | 1251.5 | 51.8 | 25.9 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | False |
| 3122 | 1251 | 1251.0 | 22.8 | 22.8 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 3123 | 1251 | 1251.0 | 20.4 | 20.4 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | False |
| 3124 | 1251 | 1251.0 | 33.6 | 33.6 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | False |
| 3125 | 1249 | 1249.0 | 25.5 | 25.5 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | False |
| 3126 | 1249 | 1249.0 | 22.6 | 22.6 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | False |
| 3127 | 1249 | 1249.0 | 26.3 | 26.3 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | False |
| 3128 | 1249 | 1249.0 | 51.2 | 51.2 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | False |
| 3129 | 2497 | 1248.5 | 60.6 | 30.3 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | False |
| 3130 | 1248 | 1248.0 | 24.6 | 24.6 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | False |
| 3131 | 1248 | 1248.0 | 32.4 | 32.4 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | False |
| 3132 | 1248 | 1248.0 | 31.9 | 31.9 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3133 | 1248 | 1248.0 | 31.8 | 31.8 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3134 | 1248 | 1248.0 | 31.7 | 31.7 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3135 | 2495 | 1247.5 | 70.1 | 35.0 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3136 | 3742 | 1247.3 | 203.4 | 67.8 | Improved metagenomic analysis with Kraken 2. | Derrick E Wood, Jennifer Lu, Ben Langmead | Genome Biol | 2019 | 31779668 | Yes |
| 3137 | 1247 | 1247.0 | 33.8 | 33.8 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3138 | 1247 | 1247.0 | 36.2 | 36.2 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | False |
| 3139 | 2493 | 1246.5 | 62.7 | 31.4 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | False |
| 3140 | 1246 | 1246.0 | 44.4 | 44.4 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | False |
| 3141 | 2492 | 1246.0 | 48.4 | 24.2 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | False |
| 3142 | 1246 | 1246.0 | 60.1 | 60.1 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3143 | 1246 | 1246.0 | 24.7 | 24.7 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | False |
| 3144 | 7473 | 1245.5 | 266.9 | 44.5 | ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. | James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling | J Chem Theory Comput | 2015 | 26574453 | Yes |
| 3145 | 3736 | 1245.3 | 91.1 | 30.4 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | False |
| 3146 | 1245 | 1245.0 | 35.5 | 35.5 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | False |
| 3147 | 1245 | 1245.0 | 27.3 | 27.3 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | False |
| 3148 | 1245 | 1245.0 | 29.2 | 29.2 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | False |
| 3149 | 1245 | 1245.0 | 25.2 | 25.2 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | False |
| 3150 | 1245 | 1245.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E MORTON | Am J Hum Genet | 1955 | 13258560 | Yes |
| 3151 | 1245 | 1245.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B MEDAWAR | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3152 | 2490 | 1245.0 | 72.4 | 36.2 | Crosstalk of reactive oxygen species and NF-κB signaling. | Michael J Morgan, Zheng-gang Liu | Cell Res | 2011 | 21187859 | False |
| 3153 | 1245 | 1245.0 | 45.6 | 45.6 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | False |
| 3154 | 3734 | 1244.7 | 113.0 | 37.7 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3155 | 2489 | 1244.5 | 66.0 | 33.0 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | False |
| 3156 | 1244 | 1244.0 | 49.0 | 49.0 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | False |
| 3157 | 2488 | 1244.0 | 65.2 | 32.6 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | False |
| 3158 | 2486 | 1243.0 | 52.3 | 26.1 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | False |
| 3159 | 1243 | 1243.0 | 30.2 | 30.2 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | False |
| 3160 | 1243 | 1243.0 | 30.1 | 30.1 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3161 | 1242 | 1242.0 | 42.0 | 42.0 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | False |
| 3162 | 2484 | 1242.0 | 69.1 | 34.5 | Mitochondria: in sickness and in health. | Jodi Nunnari, Anu Suomalainen | Cell | 2012 | 22424226 | False |
| 3163 | 2483 | 1241.5 | 96.5 | 48.2 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | False |
| 3164 | 2482 | 1241.0 | 61.0 | 30.5 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | False |
| 3165 | 1241 | 1241.0 | 45.0 | 45.0 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | False |
| 3166 | 3722 | 1240.7 | 105.3 | 35.1 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3167 | 7442 | 1240.3 | 161.4 | 26.9 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3168 | 1240 | 1240.0 | 46.2 | 46.2 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | False |
| 3169 | 1240 | 1240.0 | 62.4 | 62.4 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3170 | 1240 | 1240.0 | 24.7 | 24.7 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | False |
| 3171 | 1240 | 1240.0 | 26.3 | 26.3 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | False |
| 3172 | 2478 | 1239.0 | 53.0 | 26.5 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N AMES, D T DUBIN | J Biol Chem | 1960 | 13793161 | Yes |
| 3173 | 2478 | 1239.0 | 52.4 | 26.2 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | False |
| 3174 | 8671 | 1238.7 | 263.4 | 37.6 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3175 | 1238 | 1238.0 | 39.4 | 39.4 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | False |
| 3176 | 1238 | 1238.0 | 47.5 | 47.5 | A simple method for determination of serum catalase activity and revision of reference range. | L Góth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3177 | 1238 | 1238.0 | 55.4 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 3178 | 2476 | 1238.0 | 48.0 | 24.0 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | False |
| 3179 | 1238 | 1238.0 | 26.2 | 26.2 | Human papillomavirus and cervical cancer. | Eileen M Burd | Clin Microbiol Rev | 2003 | 12525422 | False |
| 3180 | 1238 | 1238.0 | 15.3 | 15.3 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M VAN ROSSUM | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 3181 | 2475 | 1237.5 | 63.5 | 31.8 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3182 | 1237 | 1237.0 | 36.5 | 36.5 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | False |
| 3183 | 1237 | 1237.0 | 39.7 | 39.7 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | False |
| 3184 | 1237 | 1237.0 | 25.8 | 25.8 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | False |
| 3185 | 6183 | 1236.6 | 191.2 | 38.2 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 3186 | 2472 | 1236.0 | 67.7 | 33.9 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3187 | 1236 | 1236.0 | 34.8 | 34.8 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3188 | 3708 | 1236.0 | 87.0 | 29.0 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | False |
| 3189 | 2472 | 1236.0 | 68.5 | 34.2 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | False |
| 3190 | 1236 | 1236.0 | 33.0 | 33.0 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | False |
| 3191 | 3708 | 1236.0 | 96.3 | 32.1 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | False |
| 3192 | 6178 | 1235.6 | 288.6 | 57.7 | Using the framework method for the analysis of qualitative data in multi-disciplinary health research. | Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood | BMC Med Res Methodol | 2013 | 24047204 | Yes |
| 3193 | 2471 | 1235.5 | 117.8 | 58.9 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | False |
| 3194 | 1235 | 1235.0 | 15.5 | 15.5 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | False |
| 3195 | 1235 | 1235.0 | 53.5 | 53.5 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | False |
| 3196 | 2470 | 1235.0 | 49.7 | 24.9 | TM-align: a protein structure alignment algorithm based on the TM-score. | Yang Zhang, Jeffrey Skolnick | Nucleic Acids Res | 2005 | 15849316 | Yes |
| 3197 | 2469 | 1234.5 | 39.3 | 19.6 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 3198 | 7404 | 1234.0 | 134.9 | 22.5 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3199 | 1234 | 1234.0 | 28.5 | 28.5 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | False |
| 3200 | 1234 | 1234.0 | 35.5 | 35.5 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | False |
| 3201 | 8636 | 1233.7 | 247.7 | 35.4 | pROC: an open-source package for R and S+ to analyze and compare ROC curves. | Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frédérique Lisacek, Jean-Charles Sanchez, Markus Müller | BMC Bioinformatics | 2011 | 21414208 | Yes |
| 3202 | 1233 | 1233.0 | 23.4 | 23.4 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | False |
| 3203 | 1232 | 1232.0 | 28.1 | 28.1 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3204 | 1232 | 1232.0 | 35.9 | 35.9 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3205 | 1232 | 1232.0 | 25.3 | 25.3 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | False |
| 3206 | 1232 | 1232.0 | 36.7 | 36.7 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | False |
| 3207 | 1232 | 1232.0 | 28.8 | 28.8 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | False |
| 3208 | 6156 | 1231.2 | 235.3 | 47.1 | Frailty in elderly people. | Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood | Lancet | 2013 | 23395245 | False |
| 3209 | 1231 | 1231.0 | 36.8 | 36.8 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | False |
| 3210 | 1231 | 1231.0 | 45.8 | 45.8 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | False |
| 3211 | 2461 | 1230.5 | 50.0 | 25.0 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | False |
| 3212 | 1230 | 1230.0 | 33.9 | 33.9 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 3213 | 2460 | 1230.0 | 71.8 | 35.9 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3214 | 1230 | 1230.0 | 20.9 | 20.9 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | False |
| 3215 | 1230 | 1230.0 | 22.3 | 22.3 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | False |
| 3216 | 1230 | 1230.0 | 30.5 | 30.5 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3217 | 1229 | 1229.0 | 31.9 | 31.9 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 3218 | 1229 | 1229.0 | 25.9 | 25.9 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | False |
| 3219 | 1229 | 1229.0 | 23.0 | 23.0 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | False |
| 3220 | 1229 | 1229.0 | 27.1 | 27.1 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | False |
| 3221 | 3686 | 1228.7 | 73.7 | 24.6 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | False |
| 3222 | 2457 | 1228.5 | 206.7 | 103.3 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3223 | 2457 | 1228.5 | 76.2 | 38.1 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | False |
| 3224 | 6141 | 1228.2 | 204.3 | 40.9 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3225 | 6141 | 1228.2 | 112.2 | 22.4 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | False |
| 3226 | 1228 | 1228.0 | 58.6 | 58.6 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3227 | 1228 | 1228.0 | 45.6 | 45.6 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3228 | 2454 | 1227.0 | 63.2 | 31.6 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | False |
| 3229 | 1227 | 1227.0 | 26.5 | 26.5 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3230 | 1227 | 1227.0 | 30.5 | 30.5 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | False |
| 3231 | 3679 | 1226.3 | 71.2 | 23.7 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | False |
| 3232 | 2452 | 1226.0 | 53.9 | 26.9 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 3233 | 1226 | 1226.0 | 24.8 | 24.8 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3234 | 1226 | 1226.0 | 25.0 | 25.0 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | False |
| 3235 | 1226 | 1226.0 | 31.7 | 31.7 | Philosophical conceptions of the self: implications for cognitive science. | I Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3236 | 1226 | 1226.0 | 30.1 | 30.1 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | False |
| 3237 | 2451 | 1225.5 | 105.3 | 52.6 | Principal component analysis: a review and recent developments. | Ian T Jolliffe, Jorge Cadima | Philos Trans A Math Phys Eng Sci | 2016 | 26953178 | False |
| 3238 | 1225 | 1225.0 | 28.4 | 28.4 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | False |
| 3239 | 2450 | 1225.0 | 89.4 | 44.7 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3240 | 1225 | 1225.0 | 37.3 | 37.3 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | False |
| 3241 | 1225 | 1225.0 | 30.4 | 30.4 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | False |
| 3242 | 1225 | 1225.0 | 27.2 | 27.2 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | False |
| 3243 | 1225 | 1225.0 | 25.1 | 25.1 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | False |
| 3244 | 1224 | 1224.0 | 33.8 | 33.8 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | False |
| 3245 | 1224 | 1224.0 | 22.1 | 22.1 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 3246 | 1224 | 1224.0 | 33.6 | 33.6 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | False |
| 3247 | 1224 | 1224.0 | 24.4 | 24.4 | Searching for intellectual turning points: progressive knowledge domain visualization. | Chaomei Chen | Proc Natl Acad Sci U S A | 2004 | 14724295 | Yes |
| 3248 | 2448 | 1224.0 | 51.9 | 25.9 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | False |
| 3249 | 2447 | 1223.5 | 90.3 | 45.1 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3250 | 1223 | 1223.0 | 58.6 | 58.6 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | False |
| 3251 | 1223 | 1223.0 | 74.6 | 74.6 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3252 | 2446 | 1223.0 | 69.0 | 34.5 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | False |
| 3253 | 1222 | 1222.0 | 31.7 | 31.7 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3254 | 2442 | 1221.0 | 83.6 | 41.8 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | False |
| 3255 | 1221 | 1221.0 | 25.8 | 25.8 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | False |
| 3256 | 1221 | 1221.0 | 23.8 | 23.8 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | False |
| 3257 | 1221 | 1221.0 | 26.6 | 26.6 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | False |
| 3258 | 1221 | 1221.0 | 22.7 | 22.7 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | False |
| 3259 | 1221 | 1221.0 | 21.1 | 21.1 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat Rev Immunol | 2005 | 15928679 | False |
| 3260 | 3662 | 1220.7 | 60.5 | 20.2 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3261 | 1220 | 1220.0 | 25.0 | 25.0 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | False |
| 3262 | 1220 | 1220.0 | 31.1 | 31.1 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | False |
| 3263 | 1220 | 1220.0 | 23.6 | 23.6 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | False |
| 3264 | 2438 | 1219.0 | 82.4 | 41.2 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | False |
| 3265 | 1219 | 1219.0 | 40.8 | 40.8 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | False |
| 3266 | 2438 | 1219.0 | 48.7 | 24.4 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | False |
| 3267 | 2438 | 1219.0 | 67.2 | 33.6 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3268 | 1219 | 1219.0 | 39.1 | 39.1 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | False |
| 3269 | 2437 | 1218.5 | 72.2 | 36.1 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3270 | 1218 | 1218.0 | 28.1 | 28.1 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3271 | 2436 | 1218.0 | 26.0 | 13.0 | The Aggregation Of Blood Platelets. | G V BORN, M J CROSS | J Physiol | 1963 | 14056485 | Yes |
| 3272 | 1218 | 1218.0 | 29.1 | 29.1 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | False |
| 3273 | 7308 | 1218.0 | 277.1 | 46.2 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3274 | 3653 | 1217.7 | 101.7 | 33.9 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3275 | 1217 | 1217.0 | 28.7 | 28.7 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | False |
| 3276 | 1217 | 1217.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A MERTON | J Physiol | 1954 | 13152698 | Yes |
| 3277 | 4867 | 1216.8 | 139.1 | 34.8 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3278 | 2433 | 1216.5 | 53.9 | 26.9 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3279 | 1216 | 1216.0 | 29.0 | 29.0 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | False |
| 3280 | 2432 | 1216.0 | 71.4 | 35.7 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | False |
| 3281 | 1216 | 1216.0 | 28.2 | 28.2 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3282 | 6080 | 1216.0 | 163.3 | 32.7 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3283 | 3647 | 1215.7 | 102.8 | 34.3 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3284 | 3646 | 1215.3 | 72.3 | 24.1 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3285 | 3646 | 1215.3 | 111.9 | 37.3 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | False |
| 3286 | 1214 | 1214.0 | 48.3 | 48.3 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | False |
| 3287 | 1214 | 1214.0 | 32.8 | 32.8 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | False |
| 3288 | 1214 | 1214.0 | 23.9 | 23.9 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3289 | 1214 | 1214.0 | 32.6 | 32.6 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | False |
| 3290 | 1214 | 1214.0 | 29.1 | 29.1 | Identifying and characterizing binding sites and assessing druggability. | Thomas A Halgren | J Chem Inf Model | 2009 | 19434839 | Yes |
| 3291 | 2427 | 1213.5 | 34.9 | 17.4 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3292 | 2427 | 1213.5 | 81.1 | 40.5 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | False |
| 3293 | 2427 | 1213.5 | 54.6 | 27.3 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | False |
| 3294 | 1213 | 1213.0 | 56.5 | 56.5 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3295 | 1213 | 1213.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G BUONOCORE | J Dent Res | 1955 | 13271655 | Yes |
| 3296 | 1213 | 1213.0 | 23.7 | 23.7 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | False |
| 3297 | 1213 | 1213.0 | 32.9 | 32.9 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | False |
| 3298 | 2425 | 1212.5 | 56.9 | 28.4 | Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. | In Suk Joung, Thomas E Cheatham | J Phys Chem B | 2008 | 18593145 | Yes |
| 3299 | 1212 | 1212.0 | 26.3 | 26.3 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | False |
| 3300 | 1212 | 1212.0 | 30.2 | 30.2 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | False |
| 3301 | 1212 | 1212.0 | 24.3 | 24.3 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | False |
| 3302 | 2423 | 1211.5 | 64.2 | 32.1 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | False |
| 3303 | 2423 | 1211.5 | 63.8 | 31.9 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | False |
| 3304 | 2423 | 1211.5 | 81.3 | 40.6 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | False |
| 3305 | 1211 | 1211.0 | 28.0 | 28.0 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | False |
| 3306 | 1211 | 1211.0 | 29.0 | 29.0 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | False |
| 3307 | 2422 | 1211.0 | 102.1 | 51.0 | Designing hydrogels for controlled drug delivery. | Jianyu Li, David J Mooney | Nat Rev Mater | 2016 | 29657852 | Yes |
| 3308 | 2421 | 1210.5 | 52.4 | 26.2 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | False |
| 3309 | 1210 | 1210.0 | 52.5 | 52.5 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3310 | 1210 | 1210.0 | 33.2 | 33.2 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | False |
| 3311 | 3626 | 1208.7 | 91.7 | 30.6 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3312 | 1208 | 1208.0 | 30.2 | 30.2 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | False |
| 3313 | 1208 | 1208.0 | 50.2 | 50.2 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3314 | 2416 | 1208.0 | 61.1 | 30.6 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | False |
| 3315 | 2415 | 1207.5 | 104.1 | 52.0 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3316 | 3622 | 1207.3 | 93.5 | 31.2 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3317 | 1207 | 1207.0 | 36.0 | 36.0 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | False |
| 3318 | 1207 | 1207.0 | 38.4 | 38.4 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | False |
| 3319 | 1207 | 1207.0 | 108.7 | 108.7 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3320 | 3620 | 1206.7 | 74.0 | 24.7 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | False |
| 3321 | 2413 | 1206.5 | 59.1 | 29.6 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3322 | 2413 | 1206.5 | 42.4 | 21.2 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | False |
| 3323 | 1206 | 1206.0 | 25.4 | 25.4 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3324 | 1206 | 1206.0 | 25.8 | 25.8 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3325 | 1206 | 1206.0 | 41.2 | 41.2 | Human milk oligosaccharides: every baby needs a sugar mama. | Lars Bode | Glycobiology | 2012 | 22513036 | False |
| 3326 | 1206 | 1206.0 | 32.7 | 32.7 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | False |
| 3327 | 2411 | 1205.5 | 87.6 | 43.8 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3328 | 7231 | 1205.2 | 161.6 | 26.9 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3329 | 1205 | 1205.0 | 41.2 | 41.2 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3330 | 2410 | 1205.0 | 88.4 | 44.2 | Comparative Protein Structure Modeling Using MODELLER. | Benjamin Webb, Andrej Sali | Curr Protoc Bioinformatics | 2016 | 27322406 | Yes |
| 3331 | 2409 | 1204.5 | 87.7 | 43.9 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3332 | 2409 | 1204.5 | 53.0 | 26.5 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3333 | 4818 | 1204.5 | 90.5 | 22.6 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3334 | 1204 | 1204.0 | 18.6 | 18.6 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3335 | 1204 | 1204.0 | 19.2 | 19.2 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | False |
| 3336 | 2408 | 1204.0 | 65.2 | 32.6 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. | Marie Cargnello, Philippe P Roux | Microbiol Mol Biol Rev | 2011 | 21372320 | False |
| 3337 | 1203 | 1203.0 | 26.9 | 26.9 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | False |
| 3338 | 2406 | 1203.0 | 57.2 | 28.6 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3339 | 1203 | 1203.0 | 34.6 | 34.6 | The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. | John Duncan | Trends Cogn Sci | 2010 | 20171926 | False |
| 3340 | 2405 | 1202.5 | 51.9 | 25.9 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3341 | 1202 | 1202.0 | 37.7 | 37.7 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | False |
| 3342 | 1202 | 1202.0 | 62.7 | 62.7 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3343 | 1202 | 1202.0 | 25.4 | 25.4 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | False |
| 3344 | 1202 | 1202.0 | 46.8 | 46.8 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | False |
| 3345 | 2403 | 1201.5 | 61.5 | 30.8 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3346 | 3604 | 1201.3 | 125.6 | 41.9 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3347 | 2402 | 1201.0 | 97.3 | 48.6 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | False |
| 3348 | 6005 | 1201.0 | 141.3 | 28.3 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3349 | 1201 | 1201.0 | 29.8 | 29.8 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3350 | 12010 | 1201.0 | 387.0 | 38.7 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3351 | 1201 | 1201.0 | 31.7 | 31.7 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3352 | 1201 | 1201.0 | 32.0 | 32.0 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3353 | 2402 | 1201.0 | 103.6 | 51.8 | The role of inflammation in depression: from evolutionary imperative to modern treatment target. | Andrew H Miller, Charles L Raison | Nat Rev Immunol | 2016 | 26711676 | False |
| 3354 | 2401 | 1200.5 | 45.8 | 22.9 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | False |
| 3355 | 1200 | 1200.0 | 48.9 | 48.9 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | False |
| 3356 | 1200 | 1200.0 | 17.7 | 17.7 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E HOPE-SIMPSON | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3357 | 3599 | 1199.7 | 91.5 | 30.5 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3358 | 2399 | 1199.5 | 68.2 | 34.1 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | False |
| 3359 | 1199 | 1199.0 | 36.5 | 36.5 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | False |
| 3360 | 3597 | 1199.0 | 110.1 | 36.7 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3361 | 1199 | 1199.0 | 20.4 | 20.4 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | False |
| 3362 | 1199 | 1199.0 | 42.0 | 42.0 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3363 | 1199 | 1199.0 | 29.6 | 29.6 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | False |
| 3364 | 1199 | 1199.0 | 34.2 | 34.2 | pegas: an R package for population genetics with an integrated-modular approach. | Emmanuel Paradis | Bioinformatics | 2010 | 20080509 | Yes |
| 3365 | 2397 | 1198.5 | 77.2 | 38.6 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3366 | 1198 | 1198.0 | 21.3 | 21.3 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3367 | 1198 | 1198.0 | 75.6 | 75.6 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3368 | 1198 | 1198.0 | 37.1 | 37.1 | The inflammatory response in myocardial injury, repair, and remodelling. | Nikolaos G Frangogiannis | Nat Rev Cardiol | 2014 | 24663091 | False |
| 3369 | 1198 | 1198.0 | 42.6 | 42.6 | Type 2 inflammation in asthma--present in most, absent in many. | John V Fahy | Nat Rev Immunol | 2015 | 25534623 | False |
| 3370 | 3593 | 1197.7 | 85.6 | 28.5 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | False |
| 3371 | 1197 | 1197.0 | 28.3 | 28.3 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3372 | 1197 | 1197.0 | 33.1 | 33.1 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | False |
| 3373 | 10772 | 1196.9 | 352.3 | 39.1 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3374 | 7181 | 1196.8 | 243.4 | 40.6 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3375 | 2393 | 1196.5 | 68.6 | 34.3 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3376 | 3589 | 1196.3 | 79.9 | 26.6 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3377 | 3588 | 1196.0 | 94.4 | 31.5 | FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | Mol Biol Evol | 2009 | 19377059 | Yes |
| 3378 | 2392 | 1196.0 | 57.2 | 28.6 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | False |
| 3379 | 2392 | 1196.0 | 67.1 | 33.5 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | False |
| 3380 | 1196 | 1196.0 | 49.2 | 49.2 | Mediation Analysis: A Practitioner's Guide. | Tyler J VanderWeele | Annu Rev Public Health | 2016 | 26653405 | False |
| 3381 | 9568 | 1196.0 | 430.7 | 53.8 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. | Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda | Nat Commun | 2019 | 30944313 | Yes |
| 3382 | 3586 | 1195.3 | 71.8 | 23.9 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | False |
| 3383 | 1195 | 1195.0 | 32.6 | 32.6 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | False |
| 3384 | 3585 | 1195.0 | 80.8 | 26.9 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernán, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3385 | 1195 | 1195.0 | 30.6 | 30.6 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | False |
| 3386 | 1195 | 1195.0 | 31.4 | 31.4 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | Yes |
| 3387 | 4779 | 1194.8 | 254.8 | 63.7 | Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. | Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun | IEEE Trans Pattern Anal Mach Intell | 2017 | 27295650 | Yes |
| 3388 | 2389 | 1194.5 | 50.0 | 25.0 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3389 | 4776 | 1194.0 | 106.4 | 26.6 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3390 | 1194 | 1194.0 | 45.2 | 45.2 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | False |
| 3391 | 9552 | 1194.0 | 291.9 | 36.5 | Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. | V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks | Am J Prev Med | 1998 | 9635069 | Yes |
| 3392 | 2388 | 1194.0 | 48.2 | 24.1 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | False |
| 3393 | 1194 | 1194.0 | 22.4 | 22.4 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | False |
| 3394 | 8355 | 1193.6 | 160.4 | 22.9 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3395 | 2387 | 1193.5 | 48.0 | 24.0 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | False |
| 3396 | 2387 | 1193.5 | 44.1 | 22.1 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | False |
| 3397 | 1193 | 1193.0 | 40.3 | 40.3 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3398 | 1193 | 1193.0 | 33.4 | 33.4 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3399 | 1193 | 1193.0 | 33.7 | 33.7 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | False |
| 3400 | 2385 | 1192.5 | 46.3 | 23.1 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3401 | 3577 | 1192.3 | 166.0 | 55.3 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3402 | 1192 | 1192.0 | 29.3 | 29.3 | Seed Germination and Dormancy. | J. D. Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3403 | 2384 | 1192.0 | 68.4 | 34.2 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | False |
| 3404 | 2383 | 1191.5 | 43.4 | 21.7 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | False |
| 3405 | 1191 | 1191.0 | 68.4 | 68.4 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | False |
| 3406 | 1191 | 1191.0 | 30.9 | 30.9 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | False |
| 3407 | 1191 | 1191.0 | 37.5 | 37.5 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3408 | 2382 | 1191.0 | 95.4 | 47.7 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3409 | 1191 | 1191.0 | 26.4 | 26.4 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | False |
| 3410 | 1191 | 1191.0 | 27.4 | 27.4 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | False |
| 3411 | 1191 | 1191.0 | 10.0 | 10.0 | A New Serum Type System In Man--The Lp System. | K BERG | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3412 | 1191 | 1191.0 | 23.4 | 23.4 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G DUNCOMBE | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3413 | 1191 | 1191.0 | 29.7 | 29.7 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3414 | 2381 | 1190.5 | 49.0 | 24.5 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | False |
| 3415 | 2381 | 1190.5 | 70.0 | 35.0 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | False |
| 3416 | 1190 | 1190.0 | 44.0 | 44.0 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3417 | 1190 | 1190.0 | 39.3 | 39.3 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | False |
| 3418 | 1190 | 1190.0 | 25.1 | 25.1 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | False |
| 3419 | 2379 | 1189.5 | 89.3 | 44.6 | Tumour heterogeneity and resistance to cancer therapies. | Ibiayi Dagogo-Jack, Alice T Shaw | Nat Rev Clin Oncol | 2018 | 29115304 | False |
| 3420 | 2378 | 1189.0 | 122.1 | 61.0 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3421 | 1189 | 1189.0 | 23.0 | 23.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B ASHWORTH | Practitioner | 1964 | 14143329 | Yes |
| 3422 | 1189 | 1189.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3423 | 7132 | 1188.7 | 150.1 | 25.0 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3424 | 2377 | 1188.5 | 37.5 | 18.8 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3425 | 2377 | 1188.5 | 52.4 | 26.2 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3426 | 2377 | 1188.5 | 50.3 | 25.1 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | False |
| 3427 | 2377 | 1188.5 | 49.6 | 24.8 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | False |
| 3428 | 2377 | 1188.5 | 67.9 | 34.0 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | False |
| 3429 | 2377 | 1188.5 | 92.9 | 46.5 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. | Michael A Gimbrone, Guillermo García-Cardeña | Circ Res | 2016 | 26892962 | False |
| 3430 | 11881 | 1188.1 | 262.5 | 26.2 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3431 | 1188 | 1188.0 | 34.0 | 34.0 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | False |
| 3432 | 1188 | 1188.0 | 22.8 | 22.8 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | False |
| 3433 | 3563 | 1187.7 | 119.6 | 39.9 | Ecological momentary assessment. | Saul Shiffman, Arthur A Stone, Michael R Hufford | Annu Rev Clin Psychol | 2008 | 18509902 | False |
| 3434 | 3563 | 1187.7 | 125.4 | 41.8 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. | Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott | Physiol Rev | 2014 | 24987008 | False |
| 3435 | 16618 | 1187.0 | 350.7 | 25.1 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3436 | 1187 | 1187.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C CHANG | Nature | 1951 | 14882325 | Yes |
| 3437 | 1187 | 1187.0 | 37.1 | 37.1 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan St B T Evans | Annu Rev Psychol | 2008 | 18154502 | False |
| 3438 | 5931 | 1186.2 | 191.3 | 38.3 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | False |
| 3439 | 2372 | 1186.0 | 111.3 | 55.6 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3440 | 2372 | 1186.0 | 56.4 | 28.2 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | False |
| 3441 | 4742 | 1185.5 | 113.7 | 28.4 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3442 | 3556 | 1185.3 | 119.1 | 39.7 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | False |
| 3443 | 1185 | 1185.0 | 58.2 | 58.2 | Osseointegration and its experimental background. | P I Brånemark | J Prosthet Dent | 1983 | 6352924 | False |
| 3444 | 1185 | 1185.0 | 22.0 | 22.0 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | False |
| 3445 | 3555 | 1185.0 | 140.2 | 46.7 | Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. | Antonio Ayala, Mario F Muñoz, Sandro Argüelles | Oxid Med Cell Longev | 2014 | 24999379 | False |
| 3446 | 4739 | 1184.8 | 109.3 | 27.3 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3447 | 1184 | 1184.0 | 36.2 | 36.2 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | False |
| 3448 | 1184 | 1184.0 | 20.8 | 20.8 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3449 | 2367 | 1183.5 | 106.1 | 53.0 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3450 | 2367 | 1183.5 | 50.5 | 25.2 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | False |
| 3451 | 13016 | 1183.3 | 241.2 | 21.9 | Model-based analysis of ChIP-Seq (MACS). | Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu | Genome Biol | 2008 | 18798982 | Yes |
| 3452 | 1183 | 1183.0 | 11.7 | 11.7 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3453 | 2366 | 1183.0 | 74.8 | 37.4 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | False |
| 3454 | 2366 | 1183.0 | 75.5 | 37.8 | Toll-like receptor signaling pathways. | Takumi Kawasaki, Taro Kawai | Front Immunol | 2014 | 25309543 | False |
| 3455 | 5914 | 1182.8 | 209.6 | 41.9 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3456 | 2365 | 1182.5 | 63.8 | 31.9 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | False |
| 3457 | 1182 | 1182.0 | 38.9 | 38.9 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | False |
| 3458 | 1182 | 1182.0 | 31.9 | 31.9 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | False |
| 3459 | 3546 | 1182.0 | 75.9 | 25.3 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | False |
| 3460 | 1182 | 1182.0 | 30.8 | 30.8 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | False |
| 3461 | 1182 | 1182.0 | 31.9 | 31.9 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | False |
| 3462 | 3545 | 1181.7 | 93.2 | 31.1 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3463 | 2363 | 1181.5 | 51.5 | 25.8 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | False |
| 3464 | 3543 | 1181.0 | 70.6 | 23.5 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3465 | 2362 | 1181.0 | 49.5 | 24.8 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | False |
| 3466 | 1181 | 1181.0 | 28.1 | 28.1 | Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" | F D Haldane | Phys Rev Lett | 1988 | 10038961 | Yes |
| 3467 | 1181 | 1181.0 | 22.1 | 22.1 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | False |
| 3468 | 2362 | 1181.0 | 56.2 | 28.1 | Interaction revisited: the difference between two estimates. | Douglas G Altman, J Martin Bland | BMJ | 2003 | 12543843 | False |
| 3469 | 1181 | 1181.0 | 27.1 | 27.1 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3470 | 2361 | 1180.5 | 64.9 | 32.5 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | False |
| 3471 | 2361 | 1180.5 | 64.2 | 32.1 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | False |
| 3472 | 2360 | 1180.0 | 73.8 | 36.9 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | False |
| 3473 | 1180 | 1180.0 | 56.3 | 56.3 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | False |
| 3474 | 1180 | 1180.0 | 26.6 | 26.6 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3475 | 2360 | 1180.0 | 55.7 | 27.9 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | False |
| 3476 | 1180 | 1180.0 | 52.8 | 52.8 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3477 | 4719 | 1179.8 | 122.4 | 30.6 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3478 | 1179 | 1179.0 | 38.2 | 38.2 | Epidemiology of heart failure. | Véronique L Roger | Circ Res | 2013 | 23989710 | False |
| 3479 | 1178 | 1178.0 | 34.7 | 34.7 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | False |
| 3480 | 1178 | 1178.0 | 26.4 | 26.4 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | False |
| 3481 | 2356 | 1178.0 | 51.2 | 25.6 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3482 | 3533 | 1177.7 | 179.2 | 59.7 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3483 | 2355 | 1177.5 | 47.3 | 23.6 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3484 | 1177 | 1177.0 | 36.7 | 36.7 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | False |
| 3485 | 1177 | 1177.0 | 51.4 | 51.4 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3486 | 2354 | 1177.0 | 42.7 | 21.4 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3487 | 1177 | 1177.0 | 30.0 | 30.0 | The quantum internet. | H J Kimble | Nature | 2008 | 18563153 | Yes |
| 3488 | 2353 | 1176.5 | 39.7 | 19.9 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3489 | 2353 | 1176.5 | 94.2 | 47.1 | Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. | T J Cole, T Lobstein | Pediatr Obes | 2012 | 22715120 | Yes |
| 3490 | 1176 | 1176.0 | 62.1 | 62.1 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3491 | 1176 | 1176.0 | 29.1 | 29.1 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | False |
| 3492 | 1176 | 1176.0 | 23.9 | 23.9 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3493 | 2350 | 1175.0 | 84.8 | 42.4 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3494 | 1175 | 1175.0 | 53.1 | 53.1 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3495 | 1175 | 1175.0 | 43.7 | 43.7 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3496 | 3525 | 1175.0 | 96.2 | 32.1 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3497 | 1175 | 1175.0 | 30.6 | 30.6 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3498 | 1175 | 1175.0 | 30.8 | 30.8 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | False |
| 3499 | 1175 | 1175.0 | 28.8 | 28.8 | Overview of the immune response. | David D Chaplin | J Allergy Clin Immunol | 2010 | 20176265 | False |
| 3500 | 3524 | 1174.7 | 227.2 | 75.7 | How to perform a meta-analysis with R: a practical tutorial. | Sara Balduzzi, Gerta Rücker, Guido Schwarzer | Evid Based Ment Health | 2019 | 31563865 | Yes |
| 3501 | 4697 | 1174.2 | 120.9 | 30.2 | Mussel-inspired surface chemistry for multifunctional coatings. | Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith | Science | 2007 | 17947576 | Yes |
| 3502 | 1174 | 1174.0 | 39.2 | 39.2 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | False |
| 3503 | 1174 | 1174.0 | 32.2 | 32.2 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | False |
| 3504 | 1174 | 1174.0 | 0.0 | 0.0 | The powerful placebo. | H K BEECHER | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3505 | 1174 | 1174.0 | 26.9 | 26.9 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | False |
| 3506 | 1174 | 1174.0 | 34.1 | 34.1 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bünzli | Chem Rev | 2010 | 20151630 | False |
| 3507 | 1174 | 1174.0 | 33.4 | 33.4 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | False |
| 3508 | 2348 | 1174.0 | 73.2 | 36.6 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | False |
| 3509 | 2346 | 1173.0 | 57.8 | 28.9 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | False |
| 3510 | 1173 | 1173.0 | 28.6 | 28.6 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | False |
| 3511 | 1173 | 1173.0 | 38.8 | 38.8 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3512 | 1173 | 1173.0 | 44.0 | 44.0 | The angular gyrus: multiple functions and multiple subdivisions. | Mohamed L Seghier | Neuroscientist | 2013 | 22547530 | False |
| 3513 | 2345 | 1172.5 | 56.1 | 28.1 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | False |
| 3514 | 2345 | 1172.5 | 63.5 | 31.8 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3515 | 1172 | 1172.0 | 26.1 | 26.1 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | False |
| 3516 | 1172 | 1172.0 | 52.8 | 52.8 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3517 | 1172 | 1172.0 | 36.8 | 36.8 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3518 | 1172 | 1172.0 | 29.1 | 29.1 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | False |
| 3519 | 1172 | 1172.0 | 34.2 | 34.2 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | False |
| 3520 | 1172 | 1172.0 | 26.3 | 26.3 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | False |
| 3521 | 1171 | 1171.0 | 31.8 | 31.8 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | False |
| 3522 | 1171 | 1171.0 | 30.5 | 30.5 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3523 | 1171 | 1171.0 | 39.4 | 39.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3524 | 1171 | 1171.0 | 25.8 | 25.8 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3525 | 1171 | 1171.0 | 24.2 | 24.2 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | False |
| 3526 | 2342 | 1171.0 | 77.3 | 38.6 | The gut microbiota--masters of host development and physiology. | Felix Sommer, Fredrik Bäckhed | Nat Rev Microbiol | 2013 | 23435359 | False |
| 3527 | 1171 | 1171.0 | 33.2 | 33.2 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | False |
| 3528 | 2341 | 1170.5 | 90.1 | 45.0 | Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. | N L Glass, G C Donaldson | Appl Environ Microbiol | 1995 | 7747954 | Yes |
| 3529 | 2341 | 1170.5 | 76.9 | 38.5 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | False |
| 3530 | 1170 | 1170.0 | 34.9 | 34.9 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | False |
| 3531 | 1170 | 1170.0 | 34.0 | 34.0 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | False |
| 3532 | 1170 | 1170.0 | 21.3 | 21.3 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | False |
| 3533 | 1170 | 1170.0 | 28.2 | 28.2 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | False |
| 3534 | 1170 | 1170.0 | 34.7 | 34.7 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | False |
| 3535 | 1170 | 1170.0 | 23.1 | 23.1 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | False |
| 3536 | 2339 | 1169.5 | 43.4 | 21.7 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | False |
| 3537 | 3508 | 1169.3 | 141.3 | 47.1 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3538 | 3508 | 1169.3 | 118.6 | 39.5 | Social relationships and mortality risk: a meta-analytic review. | Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton | PLoS Med | 2010 | 20668659 | False |
| 3539 | 2338 | 1169.0 | 66.9 | 33.5 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | False |
| 3540 | 1168 | 1168.0 | 34.0 | 34.0 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | False |
| 3541 | 1168 | 1168.0 | 11.5 | 11.5 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3542 | 1168 | 1168.0 | 33.6 | 33.6 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | False |
| 3543 | 1168 | 1168.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B REXED | J Comp Neurol | 1952 | 14946260 | Yes |
| 3544 | 1168 | 1168.0 | 29.9 | 29.9 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | False |
| 3545 | 1168 | 1168.0 | 30.4 | 30.4 | Inflammation 2010: new adventures of an old flame. | Ruslan Medzhitov | Cell | 2010 | 20303867 | False |
| 3546 | 2336 | 1168.0 | 97.7 | 48.9 | Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. | Douglas J Morrison, Tom Preston | Gut Microbes | 2016 | 26963409 | False |
| 3547 | 2335 | 1167.5 | 94.4 | 47.2 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3548 | 1167 | 1167.0 | 24.0 | 24.0 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | False |
| 3549 | 3501 | 1167.0 | 89.8 | 29.9 | Fluorine in pharmaceuticals: looking beyond intuition. | Klaus Müller, Christoph Faeh, François Diederich | Science | 2007 | 17901324 | False |
| 3550 | 2334 | 1167.0 | 50.5 | 25.2 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | False |
| 3551 | 3500 | 1166.7 | 80.4 | 26.8 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3552 | 3498 | 1166.0 | 74.2 | 24.7 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3553 | 1166 | 1166.0 | 34.3 | 34.3 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3554 | 2332 | 1166.0 | 72.8 | 36.4 | Infernal 1.1: 100-fold faster RNA homology searches. | Eric P Nawrocki, Sean R Eddy | Bioinformatics | 2013 | 24008419 | Yes |
| 3555 | 1165 | 1165.0 | 24.2 | 24.2 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3556 | 1165 | 1165.0 | 31.3 | 31.3 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | False |
| 3557 | 1165 | 1165.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J FAIRBANK | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3558 | 1165 | 1165.0 | 26.9 | 26.9 | Matrix eQTL: ultra fast eQTL analysis via large matrix operations. | Andrey A Shabalin | Bioinformatics | 2012 | 22492648 | Yes |
| 3559 | 1165 | 1165.0 | 39.8 | 39.8 | DREADDs for Neuroscientists. | Bryan L Roth | Neuron | 2016 | 26889809 | False |
| 3560 | 2329 | 1164.5 | 49.2 | 24.6 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | False |
| 3561 | 2329 | 1164.5 | 91.6 | 45.8 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jérôme Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | False |
| 3562 | 1164 | 1164.0 | 42.6 | 42.6 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | False |
| 3563 | 5820 | 1164.0 | 113.4 | 22.7 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3564 | 1164 | 1164.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B BROWN | Biochem J | 1955 | 14389222 | Yes |
| 3565 | 1163 | 1163.0 | 26.6 | 26.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | False |
| 3566 | 1163 | 1163.0 | 31.4 | 31.4 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | False |
| 3567 | 1163 | 1163.0 | 33.1 | 33.1 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3568 | 1163 | 1163.0 | 31.8 | 31.8 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | False |
| 3569 | 1163 | 1163.0 | 43.8 | 43.8 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | False |
| 3570 | 1162 | 1162.0 | 20.8 | 20.8 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | False |
| 3571 | 1162 | 1162.0 | 21.6 | 21.6 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | False |
| 3572 | 1162 | 1162.0 | 30.2 | 30.2 | Neural stimulation and recording electrodes. | Stuart F Cogan | Annu Rev Biomed Eng | 2008 | 18429704 | False |
| 3573 | 1161 | 1161.0 | 30.4 | 30.4 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3574 | 2322 | 1161.0 | 46.9 | 23.4 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3575 | 1161 | 1161.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E BULBRING | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3576 | 2321 | 1160.5 | 86.5 | 43.2 | OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. | David M Emms, Steven Kelly | Genome Biol | 2015 | 26243257 | Yes |
| 3577 | 1160 | 1160.0 | 35.0 | 35.0 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | False |
| 3578 | 1160 | 1160.0 | 35.5 | 35.5 | The Danish Cancer Registry. | Marianne Lundkjær Gjerstorff | Scand J Public Health | 2011 | 21775350 | Yes |
| 3579 | 1160 | 1160.0 | 32.5 | 32.5 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. | Masabumi Shibuya | Genes Cancer | 2011 | 22866201 | Yes |
| 3580 | 2319 | 1159.5 | 66.6 | 33.3 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3581 | 1159 | 1159.0 | 24.4 | 24.4 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3582 | 1159 | 1159.0 | 26.0 | 26.0 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | False |
| 3583 | 1159 | 1159.0 | 24.2 | 24.2 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3584 | 1159 | 1159.0 | 25.6 | 25.6 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | False |
| 3585 | 2318 | 1159.0 | 80.4 | 40.2 | ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. | Tauno Metsalu, Jaak Vilo | Nucleic Acids Res | 2015 | 25969447 | Yes |
| 3586 | 2316 | 1158.0 | 131.5 | 65.8 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W BUTCHER, E W SUTHERLAND | J Biol Chem | 1962 | 13875173 | Yes |
| 3587 | 1158 | 1158.0 | 25.7 | 25.7 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | False |
| 3588 | 1158 | 1158.0 | 39.6 | 39.6 | Considerations in determining sample size for pilot studies. | Melody A Hertzog | Res Nurs Health | 2008 | 18183564 | False |
| 3589 | 2315 | 1157.5 | 56.6 | 28.3 | Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. | Sophia Y Lunt, Matthew G Vander Heiden | Annu Rev Cell Dev Biol | 2011 | 21985671 | False |
| 3590 | 1157 | 1157.0 | 37.5 | 37.5 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | False |
| 3591 | 1157 | 1157.0 | 34.8 | 34.8 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3592 | 3470 | 1156.7 | 105.1 | 35.0 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. | Irith Wiegand, Kai Hilpert, Robert E W Hancock | Nat Protoc | 2008 | 18274517 | Yes |
| 3593 | 1156 | 1156.0 | 24.3 | 24.3 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3594 | 1156 | 1156.0 | 27.5 | 27.5 | Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. | R Zahorec | Bratisl Lek Listy | 2001 | 11723675 | Yes |
| 3595 | 1156 | 1156.0 | 20.4 | 20.4 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | False |
| 3596 | 1156 | 1156.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J VAGUE | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3597 | 1156 | 1156.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3598 | 1156 | 1156.0 | 41.9 | 41.9 | Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. | Georgia Salanti | Res Synth Methods | 2012 | 26062083 | Yes |
| 3599 | 2312 | 1156.0 | 89.2 | 44.6 | The Human Intestinal Microbiome in Health and Disease. | Susan V Lynch, Oluf Pedersen | N Engl J Med | 2016 | 27974040 | False |
| 3600 | 3467 | 1155.7 | 84.2 | 28.1 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3601 | 2310 | 1155.0 | 70.2 | 35.1 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | False |
| 3602 | 1155 | 1155.0 | 29.3 | 29.3 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3603 | 1155 | 1155.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R VANE | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3604 | 2310 | 1155.0 | 60.5 | 30.2 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. | Maria M Mihaylova, Reuben J Shaw | Nat Cell Biol | 2011 | 21892142 | False |
| 3605 | 5773 | 1154.6 | 232.5 | 46.5 | KEGG: new perspectives on genomes, pathways, diseases and drugs. | Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima | Nucleic Acids Res | 2017 | 27899662 | Yes |
| 3606 | 2309 | 1154.5 | 60.9 | 30.4 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3607 | 2308 | 1154.0 | 68.9 | 34.5 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3608 | 2308 | 1154.0 | 58.8 | 29.4 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | False |
| 3609 | 1154 | 1154.0 | 34.0 | 34.0 | The mental health continuum: from languishing to flourishing in life. | Corey L M Keyes | J Health Soc Behav | 2002 | 12096700 | Yes |
| 3610 | 1154 | 1154.0 | 57.5 | 57.5 | Resin composite--state of the art. | Jack L Ferracane | Dent Mater | 2011 | 21093034 | False |
| 3611 | 1154 | 1154.0 | 27.7 | 27.7 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | False |
| 3612 | 3461 | 1153.7 | 135.3 | 45.1 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3613 | 2307 | 1153.5 | 49.2 | 24.6 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | False |
| 3614 | 1153 | 1153.0 | 33.6 | 33.6 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3615 | 1153 | 1153.0 | 22.0 | 22.0 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | False |
| 3616 | 1153 | 1153.0 | 54.4 | 54.4 | A decade of immune-checkpoint inhibitors in cancer therapy. | Caroline Robert | Nat Commun | 2020 | 32732879 | Yes |
| 3617 | 3458 | 1152.7 | 72.7 | 24.2 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3618 | 2305 | 1152.5 | 60.6 | 30.3 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3619 | 6914 | 1152.3 | 178.1 | 29.7 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3620 | 1152 | 1152.0 | 30.9 | 30.9 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | False |
| 3621 | 2304 | 1152.0 | 46.0 | 23.0 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 3622 | 1152 | 1152.0 | 32.2 | 32.2 | Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. | J C Morris | Int Psychogeriatr | 1997 | 9447441 | Yes |
| 3623 | 1152 | 1152.0 | 21.1 | 21.1 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | False |
| 3624 | 1152 | 1152.0 | 30.6 | 30.6 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3625 | 1152 | 1152.0 | 34.5 | 34.5 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | False |
| 3626 | 2304 | 1152.0 | 58.3 | 29.1 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | False |
| 3627 | 2303 | 1151.5 | 62.0 | 31.0 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3628 | 1151 | 1151.0 | 28.3 | 28.3 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | False |
| 3629 | 2302 | 1151.0 | 58.9 | 29.4 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | False |
| 3630 | 1151 | 1151.0 | 29.4 | 29.4 | The complex world of WNT receptor signalling. | Christof Niehrs | Nat Rev Mol Cell Biol | 2012 | 23151663 | False |
| 3631 | 1151 | 1151.0 | 49.2 | 49.2 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. | Daniel J Drucker | Cell Metab | 2018 | 29617641 | False |
| 3632 | 2301 | 1150.5 | 50.5 | 25.2 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | False |
| 3633 | 2300 | 1150.0 | 48.2 | 24.1 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3634 | 2300 | 1150.0 | 66.6 | 33.3 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | False |
| 3635 | 1150 | 1150.0 | 27.1 | 27.1 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3636 | 1150 | 1150.0 | 29.4 | 29.4 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | False |
| 3637 | 1150 | 1150.0 | 21.9 | 21.9 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3638 | 3450 | 1150.0 | 175.3 | 58.4 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | False |
| 3639 | 2299 | 1149.5 | 76.9 | 38.5 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N Engl J Med | 1992 | 1307234 | Yes |
| 3640 | 4598 | 1149.5 | 107.7 | 26.9 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3641 | 1149 | 1149.0 | 32.0 | 32.0 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | False |
| 3642 | 1149 | 1149.0 | 42.4 | 42.4 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | False |
| 3643 | 1149 | 1149.0 | 23.2 | 23.2 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | False |
| 3644 | 1149 | 1149.0 | 21.8 | 21.8 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | False |
| 3645 | 1149 | 1149.0 | 24.0 | 24.0 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | False |
| 3646 | 2297 | 1148.5 | 49.9 | 24.9 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | False |
| 3647 | 1148 | 1148.0 | 32.3 | 32.3 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | False |
| 3648 | 1148 | 1148.0 | 34.3 | 34.3 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3649 | 1148 | 1148.0 | 23.9 | 23.9 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | False |
| 3650 | 1148 | 1148.0 | 20.9 | 20.9 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | False |
| 3651 | 1148 | 1148.0 | 38.6 | 38.6 | Constructive and unconstructive repetitive thought. | Edward R Watkins | Psychol Bull | 2008 | 18298268 | False |
| 3652 | 1148 | 1148.0 | 35.0 | 35.0 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | False |
| 3653 | 3443 | 1147.7 | 99.0 | 33.0 | Macrophage biology in development, homeostasis and disease. | Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard | Nature | 2013 | 23619691 | False |
| 3654 | 2295 | 1147.5 | 46.6 | 23.3 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3655 | 2295 | 1147.5 | 56.4 | 28.2 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | False |
| 3656 | 3442 | 1147.3 | 170.5 | 56.8 | Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. | Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas | Nurs Health Sci | 2013 | 23480423 | False |
| 3657 | 1147 | 1147.0 | 21.6 | 21.6 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | False |
| 3658 | 1147 | 1147.0 | 21.7 | 21.7 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 3659 | 1147 | 1147.0 | 41.2 | 41.2 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3660 | 1147 | 1147.0 | 28.6 | 28.6 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | False |
| 3661 | 4587 | 1146.8 | 109.7 | 27.4 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 3662 | 1146 | 1146.0 | 31.1 | 31.1 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3663 | 1146 | 1146.0 | 33.1 | 33.1 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3664 | 1146 | 1146.0 | 20.2 | 20.2 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | False |
| 3665 | 2291 | 1145.5 | 53.1 | 26.6 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3666 | 2290 | 1145.0 | 44.3 | 22.1 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | False |
| 3667 | 3435 | 1145.0 | 87.8 | 29.3 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3668 | 1145 | 1145.0 | 22.8 | 22.8 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | False |
| 3669 | 1145 | 1145.0 | 29.0 | 29.0 | Gibberellin metabolism and its regulation. | Shinjiro Yamaguchi | Annu Rev Plant Biol | 2008 | 18173378 | False |
| 3670 | 1145 | 1145.0 | 44.9 | 44.9 | Vitamin D metabolism, mechanism of action, and clinical applications. | Daniel D Bikle | Chem Biol | 2014 | 24529992 | False |
| 3671 | 3434 | 1144.7 | 98.0 | 32.7 | AMPK: a nutrient and energy sensor that maintains energy homeostasis. | D Grahame Hardie, Fiona A Ross, Simon A Hawley | Nat Rev Mol Cell Biol | 2012 | 22436748 | False |
| 3672 | 1144 | 1144.0 | 19.1 | 19.1 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3673 | 2288 | 1144.0 | 45.0 | 22.5 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | False |
| 3674 | 1144 | 1144.0 | 31.8 | 31.8 | Normal bone anatomy and physiology. | Bart Clarke | Clin J Am Soc Nephrol | 2008 | 18988698 | False |
| 3675 | 1144 | 1144.0 | 32.0 | 32.0 | Cellular and molecular mechanisms of renal fibrosis. | Youhua Liu | Nat Rev Nephrol | 2011 | 22009250 | False |
| 3676 | 1144 | 1144.0 | 38.5 | 38.5 | The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. | Peter C Austin | Stat Med | 2014 | 24122911 | Yes |
| 3677 | 1144 | 1144.0 | 43.1 | 43.1 | A polarizing question: do M1 and M2 microglia exist? | Richard M Ransohoff | Nat Neurosci | 2016 | 27459405 | False |
| 3678 | 1143 | 1143.0 | 44.2 | 44.2 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3679 | 1143 | 1143.0 | 28.6 | 28.6 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 3680 | 1143 | 1143.0 | 31.9 | 31.9 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 3681 | 4572 | 1143.0 | 145.9 | 36.5 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | False |
| 3682 | 1143 | 1143.0 | 20.4 | 20.4 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3683 | 1143 | 1143.0 | 30.3 | 30.3 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | False |
| 3684 | 1143 | 1143.0 | 38.9 | 38.9 | The pain self-efficacy questionnaire: Taking pain into account. | Michael K Nicholas | Eur J Pain | 2007 | 16446108 | Yes |
| 3685 | 1143 | 1143.0 | 24.5 | 24.5 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | False |
| 3686 | 1143 | 1143.0 | 31.6 | 31.6 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | False |
| 3687 | 2285 | 1142.5 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H USSING, K ZERAHN | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3688 | 2285 | 1142.5 | 58.9 | 29.4 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | False |
| 3689 | 3427 | 1142.3 | 111.0 | 37.0 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 3690 | 3426 | 1142.0 | 100.7 | 33.6 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3691 | 2284 | 1142.0 | 59.2 | 29.6 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | False |
| 3692 | 2284 | 1142.0 | 55.2 | 27.6 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3693 | 1142 | 1142.0 | 24.1 | 24.1 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | False |
| 3694 | 2283 | 1141.5 | 49.9 | 24.9 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3695 | 1141 | 1141.0 | 33.8 | 33.8 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3696 | 2282 | 1141.0 | 57.0 | 28.5 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nuñez | Nat Rev Immunol | 2010 | 21088683 | False |
| 3697 | 3422 | 1140.7 | 90.9 | 30.3 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3698 | 6843 | 1140.5 | 173.2 | 28.9 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3699 | 4562 | 1140.5 | 34.0 | 8.5 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J RANDLE, P B GARLAND, C N HALES, E A NEWSHOLME | Lancet | 1963 | 13990765 | Yes |
| 3700 | 3421 | 1140.3 | 67.8 | 22.6 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. | Juri Rappsilber, Matthias Mann, Yasushi Ishihama | Nat Protoc | 2007 | 17703201 | Yes |
| 3701 | 1140 | 1140.0 | 56.5 | 56.5 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3702 | 1140 | 1140.0 | 32.0 | 32.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3703 | 2280 | 1140.0 | 45.2 | 22.6 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | False |
| 3704 | 1140 | 1140.0 | 26.0 | 26.0 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3705 | 2280 | 1140.0 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C TRUELOVE, L J WITTS | Br Med J | 1955 | 13260656 | Yes |
| 3706 | 1140 | 1140.0 | 17.4 | 17.4 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O EGEBERG | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3707 | 1140 | 1140.0 | 67.9 | 67.9 | Diffusion-in-gel methods for immunological analysis. II. | O OUCHTERLONY | Prog Allergy | 1962 | 14482809 | Yes |
| 3708 | 1140 | 1140.0 | 28.9 | 28.9 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | False |
| 3709 | 1140 | 1140.0 | 0.0 | 0.0 | A new microscopic principle. | D GABOR | Nature | 1948 | 18860291 | Yes |
| 3710 | 1140 | 1140.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D HOTCHKISS | Arch Biochem | 1948 | 18921848 | Yes |
| 3711 | 1139 | 1139.0 | 40.6 | 40.6 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3712 | 1139 | 1139.0 | 44.8 | 44.8 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3713 | 1139 | 1139.0 | 26.8 | 26.8 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | False |
| 3714 | 1139 | 1139.0 | 31.7 | 31.7 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | False |
| 3715 | 1139 | 1139.0 | 57.7 | 57.7 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. | Héctor F Escobar-Morreale | Nat Rev Endocrinol | 2018 | 29569621 | False |
| 3716 | 2277 | 1138.5 | 41.0 | 20.5 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | False |
| 3717 | 4553 | 1138.2 | 203.2 | 50.8 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | False |
| 3718 | 1138 | 1138.0 | 16.7 | 16.7 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J PENNINGTON | Biochem J | 1961 | 13734134 | Yes |
| 3719 | 1137 | 1137.0 | 26.0 | 26.0 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3720 | 1137 | 1137.0 | 33.1 | 33.1 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | False |
| 3721 | 1137 | 1137.0 | 44.6 | 44.6 | Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). | Laura J Julian | Arthritis Care Res (Hoboken) | 2011 | 22588767 | False |
| 3722 | 1136 | 1136.0 | 40.1 | 40.1 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | False |
| 3723 | 1136 | 1136.0 | 37.6 | 37.6 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | False |
| 3724 | 2272 | 1136.0 | 62.8 | 31.4 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H. Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3725 | 2272 | 1136.0 | 45.6 | 22.8 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | False |
| 3726 | 6815 | 1135.8 | 185.9 | 31.0 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3727 | 2271 | 1135.5 | 59.3 | 29.6 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J Biol Chem | 1986 | 3456347 | Yes |
| 3728 | 2270 | 1135.0 | 72.4 | 36.2 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3729 | 1135 | 1135.0 | 41.7 | 41.7 | View through a window may influence recovery from surgery. | R S Ulrich | Science | 1984 | 6143402 | Yes |
| 3730 | 4540 | 1135.0 | 103.9 | 26.0 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 3731 | 1135 | 1135.0 | 23.7 | 23.7 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | False |
| 3732 | 1135 | 1135.0 | 26.9 | 26.9 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | False |
| 3733 | 2270 | 1135.0 | 63.1 | 31.6 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3734 | 1135 | 1135.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O SCHILD | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 3735 | 1135 | 1135.0 | 42.2 | 42.2 | Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. | Walter S Leal | Annu Rev Entomol | 2013 | 23020622 | False |
| 3736 | 1134 | 1134.0 | 34.6 | 34.6 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 3737 | 1134 | 1134.0 | 20.4 | 20.4 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 3738 | 1134 | 1134.0 | 26.8 | 26.8 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3739 | 1134 | 1134.0 | 43.9 | 43.9 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3740 | 1134 | 1134.0 | 25.8 | 25.8 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 3741 | 1134 | 1134.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3742 | 2268 | 1134.0 | 56.6 | 28.3 | Monocyte recruitment during infection and inflammation. | Chao Shi, Eric G Pamer | Nat Rev Immunol | 2011 | 21984070 | False |
| 3743 | 1134 | 1134.0 | 44.0 | 44.0 | Reference methods for the assessment of physical characteristics of meat. | K O Honikel | Meat Sci | 1998 | 22060626 | Yes |
| 3744 | 3401 | 1133.7 | 93.1 | 31.0 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 3745 | 2267 | 1133.5 | 72.1 | 36.0 | Positive psychology. An introduction. | M E Seligman, M Csikszentmihalyi | Am Psychol | 2000 | 11392865 | Yes |
| 3746 | 2267 | 1133.5 | 88.4 | 44.2 | Shared decision making--pinnacle of patient-centered care. | Michael J Barry, Susan Edgman-Levitan | N Engl J Med | 2012 | 22375967 | Yes |
| 3747 | 2267 | 1133.5 | 83.7 | 41.9 | Gut microbiota, metabolites and host immunity. | Michelle G Rooks, Wendy S Garrett | Nat Rev Immunol | 2016 | 27231050 | False |
| 3748 | 1133 | 1133.0 | 34.3 | 34.3 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | False |
| 3749 | 1133 | 1133.0 | 27.5 | 27.5 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | False |
| 3750 | 2266 | 1133.0 | 85.0 | 42.5 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3751 | 1133 | 1133.0 | 25.0 | 25.0 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 3752 | 1133 | 1133.0 | 21.0 | 21.0 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | False |
| 3753 | 1133 | 1133.0 | 29.3 | 29.3 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | False |
| 3754 | 1133 | 1133.0 | 22.8 | 22.8 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | False |
| 3755 | 1133 | 1133.0 | 33.2 | 33.2 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | False |
| 3756 | 3397 | 1132.3 | 76.3 | 25.4 | STATs in cancer inflammation and immunity: a leading role for STAT3. | Hua Yu, Drew Pardoll, Richard Jove | Nat Rev Cancer | 2009 | 19851315 | False |
| 3757 | 1132 | 1132.0 | 69.6 | 69.6 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 3758 | 1132 | 1132.0 | 26.5 | 26.5 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | False |
| 3759 | 2264 | 1132.0 | 47.3 | 23.6 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. | Javier A Menendez, Ruth Lupu | Nat Rev Cancer | 2007 | 17882277 | False |
| 3760 | 18109 | 1131.8 | 672.0 | 42.0 | SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. | Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner | J Comput Biol | 2012 | 22506599 | Yes |
| 3761 | 2263 | 1131.5 | 87.5 | 43.8 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3762 | 2263 | 1131.5 | 90.6 | 45.3 | The aggression questionnaire. | A H Buss, M Perry | J Pers Soc Psychol | 1992 | 1403624 | Yes |
| 3763 | 1131 | 1131.0 | 81.2 | 81.2 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3764 | 2261 | 1130.5 | 55.5 | 27.8 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | Laetitia Prut, Catherine Belzung | Eur J Pharmacol | 2003 | 12600700 | False |
| 3765 | 1130 | 1130.0 | 23.6 | 23.6 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | False |
| 3766 | 4520 | 1130.0 | 172.7 | 43.2 | The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. | L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg | Arch Neurol | 1989 | 2803071 | Yes |
| 3767 | 1130 | 1130.0 | 42.6 | 42.6 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | False |
| 3768 | 1130 | 1130.0 | 36.3 | 36.3 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
| 3769 | 2260 | 1130.0 | 96.0 | 48.0 | The Tumor Microenvironment Innately Modulates Cancer Progression. | Dominique C Hinshaw, Lalita A Shevde | Cancer Res | 2019 | 31350295 | False |
| 3770 | 3389 | 1129.7 | 133.3 | 44.4 | The biology and management of non-small cell lung cancer. | Roy S Herbst, Daniel Morgensztern, Chris Boshoff | Nature | 2018 | 29364287 | False |
| 3771 | 2259 | 1129.5 | 136.2 | 68.1 | Modified reagents for determination of urea and ammonia. | A L CHANEY, E P MARBACH | Clin Chem | 1962 | 13878063 | Yes |
| 3772 | 1129 | 1129.0 | 39.9 | 39.9 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | False |
| 3773 | 1129 | 1129.0 | 20.1 | 20.1 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3774 | 1129 | 1129.0 | 28.5 | 28.5 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 3775 | 1129 | 1129.0 | 33.2 | 33.2 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 3776 | 1129 | 1129.0 | 27.2 | 27.2 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | False |
| 3777 | 2258 | 1129.0 | 64.7 | 32.4 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | False |
| 3778 | 2258 | 1129.0 | 99.2 | 49.6 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. | Luigi Ferrucci, Elisa Fabbri | Nat Rev Cardiol | 2018 | 30065258 | False |
| 3779 | 2257 | 1128.5 | 55.5 | 27.8 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 3780 | 2257 | 1128.5 | 50.8 | 25.4 | Efficient behavior of small-world networks. | V Latora, M Marchiori | Phys Rev Lett | 2001 | 11690461 | Yes |
| 3781 | 2257 | 1128.5 | 40.9 | 20.4 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3782 | 1128 | 1128.0 | 28.6 | 28.6 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 3783 | 2256 | 1128.0 | 45.1 | 22.6 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 3784 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B STAVITSKY | J Immunol | 1954 | 13163409 | Yes |
| 3785 | 1128 | 1128.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
| 3786 | 2255 | 1127.5 | 36.4 | 18.2 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 3787 | 7892 | 1127.4 | 135.1 | 19.3 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3788 | 1127 | 1127.0 | 27.9 | 27.9 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | False |
| 3789 | 1127 | 1127.0 | 26.6 | 26.6 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3790 | 1127 | 1127.0 | 25.9 | 25.9 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3791 | 3381 | 1127.0 | 80.4 | 26.8 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | False |
| 3792 | 2254 | 1127.0 | 77.3 | 38.6 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
| 3793 | 1127 | 1127.0 | 28.9 | 28.9 | Electrogenerated chemiluminescence and its biorelated applications. | Wujian Miao | Chem Rev | 2008 | 18505298 | False |
| 3794 | 5633 | 1126.6 | 257.9 | 51.6 | VSEARCH: a versatile open source tool for metagenomics. | Torbjørn Rognes, Tomáš Flouri, Ben Nichols, Christopher Quince, Frédéric Mahé | PeerJ | 2016 | 27781170 | Yes |
| 3795 | 2252 | 1126.0 | 53.3 | 26.6 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3796 | 1126 | 1126.0 | 34.4 | 34.4 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | False |
| 3797 | 1126 | 1126.0 | 18.6 | 18.6 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3798 | 1126 | 1126.0 | 21.8 | 21.8 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | False |
| 3799 | 1126 | 1126.0 | 29.4 | 29.4 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | False |
| 3800 | 1126 | 1126.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L LEKSELL | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3801 | 1126 | 1126.0 | 25.7 | 25.7 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3802 | 1126 | 1126.0 | 24.0 | 24.0 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | False |
| 3803 | 1126 | 1126.0 | 24.2 | 24.2 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | False |
| 3804 | 7879 | 1125.6 | 551.0 | 78.7 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. | Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia | Mol Plant | 2020 | 32585190 | Yes |
| 3805 | 3376 | 1125.3 | 64.2 | 21.4 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3806 | 1125 | 1125.0 | 49.6 | 49.6 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | False |
| 3807 | 2250 | 1125.0 | 84.3 | 42.1 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3808 | 1125 | 1125.0 | 27.3 | 27.3 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | False |
| 3809 | 1125 | 1125.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W WHITE | Psychol Rev | 1959 | 13844397 | Yes |
| 3810 | 2250 | 1125.0 | 55.6 | 27.8 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | False |
| 3811 | 2250 | 1125.0 | 86.0 | 43.0 | Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). | Marta Kutas, Kara D Federmeier | Annu Rev Psychol | 2011 | 20809790 | False |
| 3812 | 20238 | 1124.3 | 484.9 | 26.9 | PHENIX: a comprehensive Python-based system for macromolecular structure solution. | Paul D Adams, Pavel V Afonine, Gábor Bunkóczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart | Acta Crystallogr D Biol Crystallogr | 2010 | 20124702 | Yes |
| 3813 | 1124 | 1124.0 | 25.1 | 25.1 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3814 | 2248 | 1124.0 | 99.6 | 49.8 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3815 | 2248 | 1124.0 | 48.7 | 24.4 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 3816 | 1124 | 1124.0 | 44.1 | 44.1 | Root canal irrigants. | Matthias Zehnder | J Endod | 2006 | 16631834 | False |
| 3817 | 1124 | 1124.0 | 32.1 | 32.1 | Targeting the DNA Damage Response in Cancer. | Mark J O'Connor | Mol Cell | 2015 | 26590714 | False |
| 3818 | 5619 | 1123.8 | 200.0 | 40.0 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3819 | 2247 | 1123.5 | 84.2 | 42.1 | Epidemiology of adult fractures: A review. | Charles M Court-Brown, Ben Caesar | Injury | 2006 | 16814787 | False |
| 3820 | 2246 | 1123.0 | 70.9 | 35.5 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | False |
| 3821 | 1123 | 1123.0 | 41.4 | 41.4 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 3822 | 2246 | 1123.0 | 58.0 | 29.0 | Cu-catalyzed azide-alkyne cycloaddition. | Morten Meldal, Christian Wenzel Tornøe | Chem Rev | 2008 | 18698735 | False |
| 3823 | 5613 | 1122.6 | 149.7 | 29.9 | A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi | Cell | 2011 | 21802130 | Yes |
| 3824 | 2245 | 1122.5 | 87.0 | 43.5 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3825 | 1122 | 1122.0 | 32.7 | 32.7 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | False |
| 3826 | 1122 | 1122.0 | 24.5 | 24.5 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | False |
| 3827 | 1122 | 1122.0 | 38.8 | 38.8 | Development of the practice environment scale of the Nursing Work Index. | Eileen T Lake | Res Nurs Health | 2002 | 12015780 | Yes |
| 3828 | 1122 | 1122.0 | 31.6 | 31.6 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | False |
| 3829 | 1122 | 1122.0 | 24.8 | 24.8 | What is principal component analysis? | Markus Ringnér | Nat Biotechnol | 2008 | 18327243 | Yes |
| 3830 | 2244 | 1122.0 | 82.5 | 41.2 | MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. | Martin Steinegger, Johannes Söding | Nat Biotechnol | 2017 | 29035372 | Yes |
| 3831 | 1121 | 1121.0 | 29.7 | 29.7 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 3832 | 1121 | 1121.0 | 27.7 | 27.7 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | False |
| 3833 | 1121 | 1121.0 | 23.2 | 23.2 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 3834 | 1121 | 1121.0 | 31.2 | 31.2 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | False |
| 3835 | 1121 | 1121.0 | 33.7 | 33.7 | Recommended effect size statistics for repeated measures designs. | Roger Bakeman | Behav Res Methods | 2005 | 16405133 | Yes |
| 3836 | 1120 | 1120.0 | 32.9 | 32.9 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | False |
| 3837 | 1120 | 1120.0 | 26.4 | 26.4 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | False |
| 3838 | 1120 | 1120.0 | 20.3 | 20.3 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | False |
| 3839 | 2240 | 1120.0 | 62.9 | 31.4 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 3840 | 1120 | 1120.0 | 41.2 | 41.2 | Surface-enhanced Raman spectroscopy: concepts and chemical applications. | Sebastian Schlücker | Angew Chem Int Ed Engl | 2014 | 24711218 | Yes |
| 3841 | 4477 | 1119.2 | 115.6 | 28.9 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 3842 | 3357 | 1119.0 | 119.2 | 39.7 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 3843 | 1119 | 1119.0 | 22.4 | 22.4 | Alpha-synuclein and neurodegenerative diseases. | M Goedert | Nat Rev Neurosci | 2001 | 11433374 | False |
| 3844 | 1119 | 1119.0 | 26.9 | 26.9 | Omega-3 fatty acids in inflammation and autoimmune diseases. | Artemis P Simopoulos | J Am Coll Nutr | 2002 | 12480795 | False |
| 3845 | 4476 | 1119.0 | 96.6 | 24.1 | Isolation and characterization of exosomes from cell culture supernatants and biological fluids. | Clotilde Théry, Sebastian Amigorena, Graça Raposo, Aled Clayton | Curr Protoc Cell Biol | 2006 | 18228490 | Yes |
| 3846 | 1119 | 1119.0 | 26.6 | 26.6 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | False |
| 3847 | 5594 | 1118.8 | 178.9 | 35.8 | A simulation study of the number of events per variable in logistic regression analysis. | P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein | J Clin Epidemiol | 1996 | 8970487 | Yes |
| 3848 | 1118 | 1118.0 | 37.1 | 37.1 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | False |
| 3849 | 2236 | 1118.0 | 65.5 | 32.8 | Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. | R J Ginsberg, L V Rubinstein | Ann Thorac Surg | 1995 | 7677489 | Yes |
| 3850 | 2236 | 1118.0 | 52.1 | 26.1 | A note on quantifying follow-up in studies of failure time. | M Schemper, T L Smith | Control Clin Trials | 1996 | 8889347 | Yes |
| 3851 | 1118 | 1118.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B REXED | J Comp Neurol | 1954 | 13163236 | Yes |
| 3852 | 1118 | 1118.0 | 37.4 | 37.4 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | False |
| 3853 | 1117 | 1117.0 | 23.0 | 23.0 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 3854 | 1117 | 1117.0 | 21.1 | 21.1 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | False |
| 3855 | 1117 | 1117.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 3856 | 2232 | 1116.0 | 53.9 | 26.9 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 3857 | 1116 | 1116.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A EASTERBROOK | Psychol Rev | 1959 | 13658305 | Yes |
| 3858 | 1116 | 1116.0 | 31.9 | 31.9 | The social brain in adolescence. | Sarah-Jayne Blakemore | Nat Rev Neurosci | 2008 | 18354399 | False |
| 3859 | 1116 | 1116.0 | 35.7 | 35.7 | Biomedical photoacoustic imaging. | Paul Beard | Interface Focus | 2011 | 22866233 | Yes |
| 3860 | 1116 | 1116.0 | 54.8 | 54.8 | The expanding regulatory mechanisms and cellular functions of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2020 | 32366901 | False |
| 3861 | 3347 | 1115.7 | 72.2 | 24.1 | Mitochondria, oxidants, and aging. | Robert S Balaban, Shino Nemoto, Toren Finkel | Cell | 2005 | 15734681 | False |
| 3862 | 1115 | 1115.0 | 13.3 | 13.3 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 3863 | 1115 | 1115.0 | 36.5 | 36.5 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3864 | 1115 | 1115.0 | 27.0 | 27.0 | Biological effects of resveratrol. | L Frémont | Life Sci | 2000 | 10680575 | False |
| 3865 | 1114 | 1114.0 | 28.0 | 28.0 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | False |
| 3866 | 1114 | 1114.0 | 30.5 | 30.5 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | False |
| 3867 | 1114 | 1114.0 | 23.9 | 23.9 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | False |
| 3868 | 1114 | 1114.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J DEESE | J Exp Psychol | 1959 | 13664879 | Yes |
| 3869 | 2228 | 1114.0 | 32.4 | 16.2 | Microdroplet Assay Of Human Serum Cytotoxins. | P I TERASAKI, J D MCCLELLAND | Nature | 1964 | 14248725 | Yes |
| 3870 | 1114 | 1114.0 | 23.7 | 23.7 | The action potential in mammalian central neurons. | Bruce P Bean | Nat Rev Neurosci | 2007 | 17514198 | False |
| 3871 | 2227 | 1113.5 | 66.0 | 33.0 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 3872 | 2227 | 1113.5 | 95.1 | 47.5 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 3873 | 1113 | 1113.0 | 35.4 | 35.4 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 3874 | 1113 | 1113.0 | 36.8 | 36.8 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | False |
| 3875 | 1113 | 1113.0 | 18.5 | 18.5 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | False |
| 3876 | 1113 | 1113.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W SPERRY | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 3877 | 1113 | 1113.0 | 23.5 | 23.5 | Pyramidal neurons: dendritic structure and synaptic integration. | Nelson Spruston | Nat Rev Neurosci | 2008 | 18270515 | False |
| 3878 | 4452 | 1113.0 | 141.3 | 35.3 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 3879 | 2225 | 1112.5 | 74.0 | 37.0 | Glycosylation in cancer: mechanisms and clinical implications. | Salomé S Pinho, Celso A Reis | Nat Rev Cancer | 2015 | 26289314 | False |
| 3880 | 3337 | 1112.3 | 114.6 | 38.2 | The weirdest people in the world? | Joseph Henrich, Steven J Heine, Ara Norenzayan | Behav Brain Sci | 2010 | 20550733 | Yes |
| 3881 | 1112 | 1112.0 | 40.3 | 40.3 | An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. | F G Happé | J Autism Dev Disord | 1994 | 8040158 | Yes |
| 3882 | 1112 | 1112.0 | 28.1 | 28.1 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | False |
| 3883 | 1112 | 1112.0 | 37.1 | 37.1 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
| 3884 | 1112 | 1112.0 | 22.8 | 22.8 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | False |
| 3885 | 1112 | 1112.0 | 19.0 | 19.0 | 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. | Judith K Christman | Oncogene | 2002 | 12154409 | False |
| 3886 | 2224 | 1112.0 | 26.9 | 13.4 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P GOLD, S O FREEDMAN | J Exp Med | 1965 | 14270243 | Yes |
| 3887 | 1112 | 1112.0 | 20.6 | 20.6 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | False |
| 3888 | 2224 | 1112.0 | 52.5 | 26.2 | Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Bioinformatics | 2007 | 17050570 | Yes |
| 3889 | 1112 | 1112.0 | 30.0 | 30.0 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | False |
| 3890 | 2224 | 1112.0 | 53.6 | 26.8 | The neural basis of decision making. | Joshua I Gold, Michael N Shadlen | Annu Rev Neurosci | 2007 | 17600525 | False |
| 3891 | 4447 | 1111.8 | 84.1 | 21.0 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3892 | 1111 | 1111.0 | 36.2 | 36.2 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 3893 | 1111 | 1111.0 | 33.8 | 33.8 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | False |
| 3894 | 7774 | 1110.6 | 518.6 | 74.1 | IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. | Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt von Haeseler, Robert Lanfear | Mol Biol Evol | 2020 | 32011700 | Yes |
| 3895 | 2221 | 1110.5 | 69.7 | 34.9 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | False |
| 3896 | 2221 | 1110.5 | 46.5 | 23.2 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 3897 | 1110 | 1110.0 | 23.2 | 23.2 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 3898 | 1110 | 1110.0 | 25.9 | 25.9 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 3899 | 1110 | 1110.0 | 25.6 | 25.6 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | False |
| 3900 | 1109 | 1109.0 | 25.1 | 25.1 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | False |
| 3901 | 1109 | 1109.0 | 24.5 | 24.5 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | False |
| 3902 | 1109 | 1109.0 | 25.0 | 25.0 | Mucins in cancer: function, prognosis and therapy. | Donald W Kufe | Nat Rev Cancer | 2009 | 19935676 | False |
| 3903 | 3326 | 1108.7 | 110.3 | 36.8 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 3904 | 2217 | 1108.5 | 108.3 | 54.1 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 3905 | 1108 | 1108.0 | 55.1 | 55.1 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | False |
| 3906 | 1108 | 1108.0 | 22.4 | 22.4 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | False |
| 3907 | 1108 | 1108.0 | 21.6 | 21.6 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | False |
| 3908 | 1108 | 1108.0 | 26.6 | 26.6 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | False |
| 3909 | 2215 | 1107.5 | 45.8 | 22.9 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | False |
| 3910 | 1107 | 1107.0 | 22.1 | 22.1 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | False |
| 3911 | 1107 | 1107.0 | 29.3 | 29.3 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 3912 | 1107 | 1107.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W TEALE | Biochim Biophys Acta | 1959 | 13837237 | Yes |
| 3913 | 1107 | 1107.0 | 26.6 | 26.6 | Hybridization as an invasion of the genome. | James Mallet | Trends Ecol Evol | 2005 | 16701374 | Yes |
| 3914 | 3320 | 1106.7 | 79.1 | 26.4 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. | Chun-Chi Liang, Ann Y Park, Jun-Lin Guan | Nat Protoc | 2007 | 17406593 | Yes |
| 3915 | 2213 | 1106.5 | 53.7 | 26.9 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | False |
| 3916 | 2213 | 1106.5 | 51.6 | 25.8 | The oxytocin receptor system: structure, function, and regulation. | G Gimpl, F Fahrenholz | Physiol Rev | 2001 | 11274341 | False |
| 3917 | 4425 | 1106.2 | 102.4 | 25.6 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 3918 | 1106 | 1106.0 | 11.4 | 11.4 | Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. | J J Hopfield | Proc Natl Acad Sci U S A | 1974 | 4530290 | Yes |
| 3919 | 2212 | 1106.0 | 77.5 | 38.8 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | False |
| 3920 | 1106 | 1106.0 | 31.5 | 31.5 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | False |
| 3921 | 1106 | 1106.0 | 22.4 | 22.4 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | False |
| 3922 | 1106 | 1106.0 | 38.3 | 38.3 | Microbial life in the phyllosphere. | Julia A Vorholt | Nat Rev Microbiol | 2012 | 23154261 | False |
| 3923 | 3317 | 1105.7 | 113.2 | 37.7 | The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. | Stefka Tyanova, Tikira Temu, Juergen Cox | Nat Protoc | 2016 | 27809316 | Yes |
| 3924 | 2211 | 1105.5 | 43.9 | 21.9 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Kärre | Immunol Today | 1990 | 2201309 | False |
| 3925 | 1105 | 1105.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H KASS | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 3926 | 2210 | 1105.0 | 46.5 | 23.2 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | False |
| 3927 | 4419 | 1104.8 | 159.2 | 39.8 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 3928 | 4419 | 1104.8 | 108.1 | 27.0 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 3929 | 2209 | 1104.5 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H COONS, M H KAPLAN | J Exp Med | 1950 | 15395569 | Yes |
| 3930 | 1104 | 1104.0 | 61.7 | 61.7 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | False |
| 3931 | 2208 | 1104.0 | 48.7 | 24.4 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | False |
| 3932 | 1104 | 1104.0 | 21.7 | 21.7 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | False |
| 3933 | 1104 | 1104.0 | 32.3 | 32.3 | Spontaneous dissection of the carotid and vertebral arteries. | W I Schievink | N Engl J Med | 2001 | 11259724 | False |
| 3934 | 1104 | 1104.0 | 27.0 | 27.0 | Telomere length measurement by a novel monochrome multiplex quantitative PCR method. | Richard M Cawthon | Nucleic Acids Res | 2009 | 19129229 | Yes |
| 3935 | 3312 | 1104.0 | 132.3 | 44.1 | Rheumatoid arthritis. | Josef S Smolen, Daniel Aletaha, Iain B McInnes | Lancet | 2016 | 27156434 | False |
| 3936 | 3311 | 1103.7 | 134.0 | 44.7 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 3937 | 2206 | 1103.0 | 53.3 | 26.6 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | False |
| 3938 | 5511 | 1102.2 | 114.9 | 23.0 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
| 3939 | 4408 | 1102.0 | 112.8 | 28.2 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 3940 | 2204 | 1102.0 | 49.4 | 24.7 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | False |
| 3941 | 1102 | 1102.0 | 44.5 | 44.5 | Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. | Hannah R Snyder | Psychol Bull | 2013 | 22642228 | False |
| 3942 | 1101 | 1101.0 | 27.4 | 27.4 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
| 3943 | 1101 | 1101.0 | 22.0 | 22.0 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 3944 | 1101 | 1101.0 | 29.8 | 29.8 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | False |
| 3945 | 1101 | 1101.0 | 23.0 | 23.0 | The molecular biology of coronaviruses. | Paul S Masters | Adv Virus Res | 2006 | 16877062 | False |
| 3946 | 2201 | 1100.5 | 45.3 | 22.6 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | False |
| 3947 | 11002 | 1100.2 | 450.1 | 45.0 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. | David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison | Acta Neuropathol | 2016 | 27157931 | False |
| 3948 | 3300 | 1100.0 | 109.6 | 36.5 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 3949 | 1100 | 1100.0 | 33.8 | 33.8 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | False |
| 3950 | 1100 | 1100.0 | 59.6 | 59.6 | Cisplatin: The first metal based anticancer drug. | Sumit Ghosh | Bioorg Chem | 2019 | 31003078 | False |
| 3951 | 2199 | 1099.5 | 65.3 | 32.6 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | False |
| 3952 | 2199 | 1099.5 | 63.3 | 31.6 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | False |
| 3953 | 2198 | 1099.0 | 61.0 | 30.5 | Flexible regression models with cubic splines. | S Durrleman, R Simon | Stat Med | 1989 | 2657958 | Yes |
| 3954 | 1099 | 1099.0 | 41.9 | 41.9 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | False |
| 3955 | 1099 | 1099.0 | 24.1 | 24.1 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | False |
| 3956 | 1099 | 1099.0 | 23.9 | 23.9 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | False |
| 3957 | 2198 | 1099.0 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E VAN HANDEL, D B ZILVERSMIT | J Lab Clin Med | 1957 | 13439279 | Yes |
| 3958 | 1099 | 1099.0 | 25.5 | 25.5 | The emotional brain, fear, and the amygdala. | Joseph LeDoux | Cell Mol Neurobiol | 2003 | 14514027 | False |
| 3959 | 1099 | 1099.0 | 21.5 | 21.5 | Automated NMR structure calculation with CYANA. | Peter Güntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 3960 | 1099 | 1099.0 | 29.6 | 29.6 | Innate immunity of fish (overview). | Bergljót Magnadóttir | Fish Shellfish Immunol | 2006 | 15950491 | False |
| 3961 | 1099 | 1099.0 | 21.0 | 21.0 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat Rev Genet | 2007 | 17304246 | False |
| 3962 | 1099 | 1099.0 | 31.2 | 31.2 | Conceptual synthesis in community ecology. | Mark Vellend | Q Rev Biol | 2010 | 20565040 | False |
| 3963 | 2198 | 1099.0 | 58.3 | 29.1 | DNA methylation: roles in mammalian development. | Zachary D Smith, Alexander Meissner | Nat Rev Genet | 2013 | 23400093 | False |
| 3964 | 2197 | 1098.5 | 71.3 | 35.6 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 3965 | 2197 | 1098.5 | 79.1 | 39.5 | Perceived discrimination and health: a meta-analytic review. | Elizabeth A Pascoe, Laura Smart Richman | Psychol Bull | 2009 | 19586161 | Yes |
| 3966 | 1098 | 1098.0 | 38.6 | 38.6 | Perceptual selectivity for color and form. | J Theeuwes | Percept Psychophys | 1992 | 1620571 | False |
| 3967 | 1098 | 1098.0 | 20.6 | 20.6 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
| 3968 | 2196 | 1098.0 | 64.4 | 32.2 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 3969 | 1098 | 1098.0 | 18.9 | 18.9 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | False |
| 3970 | 1098 | 1098.0 | 31.9 | 31.9 | Image matching as a diffusion process: an analogy with Maxwell's demons. | J P Thirion | Med Image Anal | 1998 | 9873902 | Yes |
| 3971 | 1098 | 1098.0 | 29.7 | 29.7 | Voltage-gated calcium channels. | William A Catterall | Cold Spring Harb Perspect Biol | 2011 | 21746798 | False |
| 3972 | 1098 | 1098.0 | 39.1 | 39.1 | T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. | Shane Crotty | Immunity | 2019 | 31117010 | False |
| 3973 | 2195 | 1097.5 | 38.1 | 19.1 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 3974 | 2195 | 1097.5 | 60.1 | 30.1 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N Engl J Med | 2007 | 17652652 | Yes |
| 3975 | 1097 | 1097.0 | 20.6 | 20.6 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
| 3976 | 1097 | 1097.0 | 20.2 | 20.2 | Cytokines in cancer pathogenesis and cancer therapy. | Glenn Dranoff | Nat Rev Cancer | 2004 | 14708024 | False |
| 3977 | 2194 | 1097.0 | 87.5 | 43.8 | Global estimates of visual impairment: 2010. | Donatella Pascolini, Silvio Paolo Mariotti | Br J Ophthalmol | 2012 | 22133988 | Yes |
| 3978 | 4388 | 1097.0 | 195.8 | 49.0 | Random effects structure for confirmatory hypothesis testing: Keep it maximal. | Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily | J Mem Lang | 2013 | 24403724 | Yes |
| 3979 | 6576 | 1096.0 | 164.0 | 27.3 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 3980 | 2192 | 1096.0 | 116.9 | 58.5 | Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. | Amy J H Kind, William R Buckingham | N Engl J Med | 2018 | 29949490 | Yes |
| 3981 | 2191 | 1095.5 | 48.8 | 24.4 | How to interpret LC3 immunoblotting. | Noboru Mizushima, Tamotsu Yoshimori | Autophagy | 2007 | 17611390 | False |
| 3982 | 2190 | 1095.0 | 64.1 | 32.0 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | False |
| 3983 | 2190 | 1095.0 | 88.8 | 44.4 | Emotional processing of fear: exposure to corrective information. | E B Foa, M J Kozak | Psychol Bull | 1986 | 2871574 | Yes |
| 3984 | 2190 | 1095.0 | 34.7 | 17.4 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | False |
| 3985 | 1095 | 1095.0 | 22.9 | 22.9 | Ligand-targeted therapeutics in anticancer therapy. | Theresa M Allen | Nat Rev Cancer | 2002 | 12360278 | False |
| 3986 | 1095 | 1095.0 | 21.4 | 21.4 | Unfolding the role of protein misfolding in neurodegenerative diseases. | Claudio Soto | Nat Rev Neurosci | 2003 | 12511861 | False |
| 3987 | 1095 | 1095.0 | 24.7 | 24.7 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | False |
| 3988 | 1095 | 1095.0 | 34.9 | 34.9 | Vitamin D status: measurement, interpretation, and clinical application. | Michael F Holick | Ann Epidemiol | 2009 | 18329892 | False |
| 3989 | 4377 | 1094.2 | 148.1 | 37.0 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 3990 | 1094 | 1094.0 | 32.4 | 32.4 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 3991 | 1094 | 1094.0 | 18.7 | 18.7 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
| 3992 | 2188 | 1094.0 | 53.8 | 26.9 | Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. | D Rice, S Barone | Environ Health Perspect | 2000 | 10852851 | False |
| 3993 | 1094 | 1094.0 | 23.6 | 23.6 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat Rev Neurosci | 2000 | 11252767 | False |
| 3994 | 1094 | 1094.0 | 0.0 | 0.0 | The purine and pyrimidine composition of deoxypentose nucleic acids. | G R WYATT | Biochem J | 1951 | 14838906 | Yes |
| 3995 | 1094 | 1094.0 | 29.3 | 29.3 | Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. | John W Newcomer | CNS Drugs | 2005 | 15998156 | False |
| 3996 | 1094 | 1094.0 | 25.4 | 25.4 | NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. | Weihai Ying | Antioxid Redox Signal | 2008 | 18020963 | False |
| 3997 | 1094 | 1094.0 | 44.9 | 44.9 | How Many Subjects Does It Take To Do A Regression Analysis. | S B Green | Multivariate Behav Res | 1991 | 26776715 | Yes |
| 3998 | 1094 | 1094.0 | 34.3 | 34.3 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 3999 | 4374 | 1093.5 | 112.6 | 28.1 | REVIGO summarizes and visualizes long lists of gene ontology terms. | Fran Supek, Matko Bošnjak, Nives Škunca, Tomislav Šmuc | PLoS One | 2011 | 21789182 | Yes |
| 4000 | 2186 | 1093.0 | 68.3 | 34.1 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | False |
| 4001 | 6558 | 1093.0 | 147.4 | 24.6 | Alpha-synuclein in Lewy bodies. | M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert | Nature | 1997 | 9278044 | Yes |
| 4002 | 1093 | 1093.0 | 18.3 | 18.3 | The concept of synthetic lethality in the context of anticancer therapy. | William G Kaelin | Nat Rev Cancer | 2005 | 16110319 | False |
| 4003 | 1093 | 1093.0 | 24.5 | 24.5 | Pathogenesis of atherosclerosis. | Erling Falk | J Am Coll Cardiol | 2006 | 16631513 | Yes |
| 4004 | 2186 | 1093.0 | 53.3 | 26.6 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief Bioinform | 2008 | 18372315 | Yes |
| 4005 | 1093 | 1093.0 | 30.9 | 30.9 | Lanthanide-based luminescent hybrid materials. | Koen Binnemans | Chem Rev | 2009 | 19650663 | Yes |
| 4006 | 1093 | 1093.0 | 23.7 | 23.7 | Cells of origin in cancer. | Jane E Visvader | Nature | 2011 | 21248838 | False |
| 4007 | 3279 | 1093.0 | 156.6 | 52.2 | The NLRP3 inflammasome: molecular activation and regulation to therapeutics. | Karen V Swanson, Meng Deng, Jenny P-Y Ting | Nat Rev Immunol | 2019 | 31036962 | False |
| 4008 | 2185 | 1092.5 | 55.7 | 27.9 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. | L Pellerin, P J Magistretti | Proc Natl Acad Sci U S A | 1994 | 7938003 | Yes |
| 4009 | 2185 | 1092.5 | 62.3 | 31.1 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | False |
| 4010 | 1092 | 1092.0 | 44.8 | 44.8 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | False |
| 4011 | 1092 | 1092.0 | 13.7 | 13.7 | The evolutionary advantage of recombination. | J Felsenstein | Genetics | 1974 | 4448362 | Yes |
| 4012 | 1092 | 1092.0 | 38.2 | 38.2 | Coronary physiology. | E O Feigl | Physiol Rev | 1983 | 6296890 | False |
| 4013 | 1092 | 1092.0 | 20.1 | 20.1 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | False |
| 4014 | 1092 | 1092.0 | 0.0 | 0.0 | Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. | S M PARTRIDGE | Nature | 1949 | 18140444 | Yes |
| 4015 | 1092 | 1092.0 | 27.8 | 27.8 | Descending pathways in motor control. | Roger N Lemon | Annu Rev Neurosci | 2008 | 18558853 | False |
| 4016 | 3275 | 1091.7 | 193.2 | 64.4 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 4017 | 2183 | 1091.5 | 45.0 | 22.5 | An energy budget for signaling in the grey matter of the brain. | D Attwell, S B Laughlin | J Cereb Blood Flow Metab | 2001 | 11598490 | False |
| 4018 | 1091 | 1091.0 | 25.1 | 25.1 | Biochemistry and genetics of von Willebrand factor. | J E Sadler | Annu Rev Biochem | 1998 | 9759493 | False |
| 4019 | 1091 | 1091.0 | 11.6 | 11.6 | The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. | C CRONE | Acta Physiol Scand | 1963 | 14078649 | Yes |
| 4020 | 2182 | 1091.0 | 63.7 | 31.9 | Genome-wide efficient mixed-model analysis for association studies. | Xiang Zhou, Matthew Stephens | Nat Genet | 2012 | 22706312 | Yes |
| 4021 | 2182 | 1091.0 | 112.5 | 56.2 | Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. | Laura M Doyle, Michael Zhuo Wang | Cells | 2019 | 31311206 | False |
| 4022 | 3271 | 1090.3 | 115.6 | 38.5 | IL-6 in inflammation, immunity, and disease. | Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto | Cold Spring Harb Perspect Biol | 2014 | 25190079 | False |
| 4023 | 1090 | 1090.0 | 37.1 | 37.1 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 4024 | 1090 | 1090.0 | 20.4 | 20.4 | The immune response of Drosophila. | Jules A Hoffmann | Nature | 2003 | 14603309 | False |
| 4025 | 2180 | 1090.0 | 52.0 | 26.0 | CpG islands and the regulation of transcription. | Aimée M Deaton, Adrian Bird | Genes Dev | 2011 | 21576262 | False |
| 4026 | 1089 | 1089.0 | 37.3 | 37.3 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann Surg | 1992 | 1503516 | False |
| 4027 | 1089 | 1089.0 | 32.3 | 32.3 | Topography of cognition: parallel distributed networks in primate association cortex. | P S Goldman-Rakic | Annu Rev Neurosci | 1988 | 3284439 | False |
| 4028 | 1089 | 1089.0 | 33.4 | 33.4 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | False |
| 4029 | 1089 | 1089.0 | 18.9 | 18.9 | Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. | W Kolch | Biochem J | 2000 | 11023813 | False |
| 4030 | 1089 | 1089.0 | 22.4 | 22.4 | Large-scale recording of neuronal ensembles. | György Buzsáki | Nat Neurosci | 2004 | 15114356 | False |
| 4031 | 1089 | 1089.0 | 43.1 | 43.1 | Epithelial Mesenchymal Transition in Tumor Metastasis. | Vivek Mittal | Annu Rev Pathol | 2018 | 29414248 | False |
| 4032 | 7622 | 1088.9 | 701.2 | 100.2 | The psychological impact of quarantine and how to reduce it: rapid review of the evidence. | Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin | Lancet | 2020 | 32112714 | False |
| 4033 | 2177 | 1088.5 | 43.6 | 21.8 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
| 4034 | 2177 | 1088.5 | 0.0 | 0.0 | A revision of the Schoenheimer-Sperry method for cholesterol determination. | W M SPERRY, M WEBB | J Biol Chem | 1950 | 14794694 | Yes |
| 4035 | 2177 | 1088.5 | 77.1 | 38.5 | Coronaviruses: an overview of their replication and pathogenesis. | Anthony R Fehr, Stanley Perlman | Methods Mol Biol | 2015 | 25720466 | False |
| 4036 | 1088 | 1088.0 | 22.7 | 22.7 | The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. | S Roseman | Chem Phys Lipids | 1970 | 5476326 | Yes |
| 4037 | 1088 | 1088.0 | 29.5 | 29.5 | Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. | R Bonnet | Antimicrob Agents Chemother | 2004 | 14693512 | False |
| 4038 | 2176 | 1088.0 | 51.7 | 25.9 | The NF-kappaB family of transcription factors and its regulation. | Andrea Oeckinghaus, Sankar Ghosh | Cold Spring Harb Perspect Biol | 2009 | 20066092 | False |
| 4039 | 2175 | 1087.5 | 51.3 | 25.6 | Peroxidase-labeled antibody. A new method of conjugation. | P K Nakane, A Kawaoi | J Histochem Cytochem | 1974 | 4443551 | Yes |
| 4040 | 2175 | 1087.5 | 48.9 | 24.4 | Mechanisms of endocytosis. | Gary J Doherty, Harvey T McMahon | Annu Rev Biochem | 2009 | 19317650 | False |
| 4041 | 1087 | 1087.0 | 40.9 | 40.9 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | False |
| 4042 | 2174 | 1087.0 | 102.4 | 51.2 | Development, reliability, and validity of a dissociation scale. | E M Bernstein, F W Putnam | J Nerv Ment Dis | 1986 | 3783140 | Yes |
| 4043 | 4348 | 1087.0 | 111.0 | 27.8 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res | 1996 | 8908518 | Yes |
| 4044 | 1087 | 1087.0 | 27.2 | 27.2 | Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. | Jill E Clarridge | Clin Microbiol Rev | 2004 | 15489351 | False |
| 4045 | 2174 | 1087.0 | 79.5 | 39.8 | Ferroptosis: Death by Lipid Peroxidation. | Wan Seok Yang, Brent R Stockwell | Trends Cell Biol | 2016 | 26653790 | False |
| 4046 | 1086 | 1086.0 | 44.6 | 44.6 | Corticosteroids and lymphoid cells. | H N Claman | N Engl J Med | 1972 | 5043524 | Yes |
| 4047 | 1086 | 1086.0 | 29.3 | 29.3 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | False |
| 4048 | 1086 | 1086.0 | 24.7 | 24.7 | Marine viruses and their biogeochemical and ecological effects. | J A Fuhrman | Nature | 1999 | 10376593 | False |
| 4049 | 1086 | 1086.0 | 23.9 | 23.9 | Immunosuppressive drugs for kidney transplantation. | Philip F Halloran | N Engl J Med | 2004 | 15616206 | False |
| 4050 | 2171 | 1085.5 | 81.2 | 40.6 | The structure of psychological well-being revisited. | C D Ryff, C L Keyes | J Pers Soc Psychol | 1995 | 7473027 | Yes |
| 4051 | 1085 | 1085.0 | 22.6 | 22.6 | T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. | R H Schwartz | Annu Rev Immunol | 1985 | 2415139 | False |
| 4052 | 1085 | 1085.0 | 10.9 | 10.9 | Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. | R M BERNE | Am J Physiol | 1963 | 13971060 | Yes |
| 4053 | 1085 | 1085.0 | 26.4 | 26.4 | Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. | Peter Fransson | Hum Brain Mapp | 2005 | 15852468 | Yes |
| 4054 | 5425 | 1085.0 | 139.8 | 28.0 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4055 | 1085 | 1085.0 | 34.8 | 34.8 | Designing cell-compatible hydrogels for biomedical applications. | Dror Seliktar | Science | 2012 | 22654050 | False |
| 4056 | 2169 | 1084.5 | 46.7 | 23.4 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | False |
| 4057 | 2169 | 1084.5 | 65.6 | 32.8 | The human microbiome: at the interface of health and disease. | Ilseung Cho, Martin J Blaser | Nat Rev Genet | 2012 | 22411464 | False |
| 4058 | 3253 | 1084.3 | 90.4 | 30.1 | Foreign body reaction to biomaterials. | James M Anderson, Analiz Rodriguez, David T Chang | Semin Immunol | 2008 | 18162407 | False |
| 4059 | 1084 | 1084.0 | 27.2 | 27.2 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | False |
| 4060 | 1084 | 1084.0 | 23.0 | 23.0 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
| 4061 | 1084 | 1084.0 | 0.0 | 0.0 | On the Absorption of Fluids from the Connective Tissue Spaces. | E H Starling | J Physiol | 1896 | 16992325 | Yes |
| 4062 | 1084 | 1084.0 | 30.8 | 30.8 | Cytochrome p450 and chemical toxicology. | F Peter Guengerich | Chem Res Toxicol | 2008 | 18052394 | False |
| 4063 | 1084 | 1084.0 | 25.6 | 25.6 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4064 | 2167 | 1083.5 | 44.9 | 22.4 | A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. | S Whelan, N Goldman | Mol Biol Evol | 2001 | 11319253 | Yes |
| 4065 | 2167 | 1083.5 | 99.2 | 49.6 | Neurobiology of addiction: a neurocircuitry analysis. | George F Koob, Nora D Volkow | Lancet Psychiatry | 2016 | 27475769 | False |
| 4066 | 3249 | 1083.0 | 81.9 | 27.3 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
| 4067 | 1083 | 1083.0 | 20.2 | 20.2 | Tetraspanin functions and associated microdomains. | Martin E Hemler | Nat Rev Mol Cell Biol | 2005 | 16314869 | False |
| 4068 | 2166 | 1083.0 | 78.9 | 39.5 | NAFLD: a multisystem disease. | Christopher D Byrne, Giovanni Targher | J Hepatol | 2015 | 25920090 | False |
| 4069 | 4331 | 1082.8 | 116.4 | 29.1 | A role for mitochondria in NLRP3 inflammasome activation. | Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp | Nature | 2011 | 21124315 | Yes |
| 4070 | 2165 | 1082.5 | 46.4 | 23.2 | Glycosylation in cellular mechanisms of health and disease. | Kazuaki Ohtsubo, Jamey D Marth | Cell | 2006 | 16959566 | False |
| 4071 | 1082 | 1082.0 | 28.7 | 28.7 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 4072 | 2164 | 1082.0 | 42.8 | 21.4 | Autophagy in health and disease: a double-edged sword. | Takahiro Shintani, Daniel J Klionsky | Science | 2004 | 15528435 | False |
| 4073 | 1082 | 1082.0 | 27.4 | 27.4 | Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. | Paul H Yancey | J Exp Biol | 2005 | 16043587 | False |
| 4074 | 1082 | 1082.0 | 23.5 | 23.5 | Principles and challenges of genomewide DNA methylation analysis. | Peter W Laird | Nat Rev Genet | 2010 | 20125086 | False |
| 4075 | 2163 | 1081.5 | 57.4 | 28.7 | The cerebellar cognitive affective syndrome. | J D Schmahmann, J C Sherman | Brain | 1998 | 9577385 | Yes |
| 4076 | 1081 | 1081.0 | 27.5 | 27.5 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
| 4077 | 1081 | 1081.0 | 18.4 | 18.4 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
| 4078 | 2161 | 1080.5 | 34.9 | 17.4 | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Lee Zou, Stephen J Elledge | Science | 2003 | 12791985 | Yes |
| 4079 | 3241 | 1080.3 | 76.6 | 25.5 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | False |
| 4080 | 3241 | 1080.3 | 121.3 | 40.4 | Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. | Michael A Postow, Robert Sidlow, Matthew D Hellmann | N Engl J Med | 2018 | 29320654 | False |
| 4081 | 1080 | 1080.0 | 29.0 | 29.0 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | False |
| 4082 | 6480 | 1080.0 | 137.4 | 22.9 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res | 1984 | 6091052 | Yes |
| 4083 | 1080 | 1080.0 | 27.2 | 27.2 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
| 4084 | 1080 | 1080.0 | 23.3 | 23.3 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | False |
| 4085 | 4320 | 1080.0 | 149.7 | 37.4 | Development of recommendations for SEMG sensors and sensor placement procedures. | H J Hermens, B Freriks, C Disselhorst-Klug, G Rau | J Electromyogr Kinesiol | 2000 | 11018445 | Yes |
| 4086 | 1080 | 1080.0 | 22.8 | 22.8 | The self-tuning neuron: synaptic scaling of excitatory synapses. | Gina G Turrigiano | Cell | 2008 | 18984155 | False |
| 4087 | 2160 | 1080.0 | 47.3 | 23.6 | p21 in cancer: intricate networks and multiple activities. | Tarek Abbas, Anindya Dutta | Nat Rev Cancer | 2009 | 19440234 | False |
| 4088 | 1080 | 1080.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
| 4089 | 1080 | 1080.0 | 35.5 | 35.5 | Targeting metastasis. | Patricia S Steeg | Nat Rev Cancer | 2016 | 27009393 | False |
| 4090 | 1079 | 1079.0 | 29.6 | 29.6 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
| 4091 | 2158 | 1079.0 | 44.3 | 22.1 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr Opin Cell Biol | 1997 | 9069255 | False |
| 4092 | 1079 | 1079.0 | 21.9 | 21.9 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | False |
| 4093 | 1079 | 1079.0 | 0.0 | 0.0 | Some informational aspects of visual perception. | F ATTNEAVE | Psychol Rev | 1954 | 13167245 | Yes |
| 4094 | 1079 | 1079.0 | 23.2 | 23.2 | Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. | Linda J Pike | J Lipid Res | 2006 | 16645198 | False |
| 4095 | 1079 | 1079.0 | 31.2 | 31.2 | G(ST) and its relatives do not measure differentiation. | Lou Jost | Mol Ecol | 2008 | 19238703 | Yes |
| 4096 | 1079 | 1079.0 | 22.8 | 22.8 | Evolution of the neocortex: a perspective from developmental biology. | Pasko Rakic | Nat Rev Neurosci | 2009 | 19763105 | False |
| 4097 | 2157 | 1078.5 | 82.4 | 41.2 | Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. | G A Diamond, J S Forrester | N Engl J Med | 1979 | 440357 | Yes |
| 4098 | 2157 | 1078.5 | 53.2 | 26.6 | Mesenchymal stem cells as trophic mediators. | Arnold I Caplan, James E Dennis | J Cell Biochem | 2006 | 16619257 | False |
| 4099 | 2157 | 1078.5 | 79.1 | 39.5 | The blood-brain barrier. | Richard Daneman, Alexandre Prat | Cold Spring Harb Perspect Biol | 2015 | 25561720 | False |
| 4100 | 1078 | 1078.0 | 33.0 | 33.0 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
| 4101 | 1078 | 1078.0 | 42.3 | 42.3 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
| 4102 | 1078 | 1078.0 | 31.6 | 31.6 | The phylogenetic regression. | A Grafen | Philos Trans R Soc Lond B Biol Sci | 1989 | 2575770 | Yes |
| 4103 | 1078 | 1078.0 | 30.5 | 30.5 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
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